Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Federal Dept./Agency | Date |
|---|---|---|---|---|---|
| CHILDREN'S MERCY HOSPITAL, THE | $525,000 | Grant | Trans-NIH Recovery Act Research Support: Chronic kidney disease (CKD) in children is a devastating illness. The prevalence of patients aged 0 ? 19 years with ESRD has grown 32% since 1990 and the mortality rate for children with ESRD receiving dialysis therapy is between 30 and 150 times that o | Health and Human Services, Department of / National Institutes of Health | 9/27/2009 |
| JAEB CENTER FOR HEALTH RESEARCH FOUNDATION, INC. | $185,700 | Grant | Trans-NIH Recovery Act Research Support: This award provides additional funding for the provision of Electronic Visual Acuity systems and other equipment for 2 U10 EY014231-08 Diabetic Retinopathy Clinical Research Network Coordinating Center. | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| YALE UNIVERSITY | $217,517 | Grant | Trans-NIH Recovery Act Research Support: Endometriosis is one of the most common benign gynecologic disorders affecting approximately 10% of women in reproductive age. It is associated with significant morbidity, including infertility and chronic pelvic pain. The annual cost of endometriosis in | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $43,200 | Grant | Trans-NIH Recovery Act Research Support: We propose to adapt an existing clinical research data management system used at Cornell University for use by our Fogarty AITRP trainees in Haiti. The existing data management program Clinvestigator is an open source-free software system we developed th | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $106,750 | Grant | Trans-NIH Recovery Act Research Support: Rationale and Relevance: Infectious diseases still account for significant morbidity and mortality in the developing world. Vaccines are one of the most cost effective advances in medical science, and if appropriately used, are potent instruments in the c | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| NEW YORK UNIVERSITY (INC) | $172,800 | Grant | Trans-NIH Recovery Act Research Support: New York University School of Medicine and the National Institute of Malaria Research (NIMR), India, have a five year joint Fogarty Global Infectious Disease training and research grant. The aim of this grant is to provide research training into the biol | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| METHODIST HOSPITAL RESEARCH INSTITUTE, THE | $72,003 | Grant | Trans-NIH Recovery Act Research Support: Studies of quantitative image processing for longitudinal neuroimaging followup have been reported for more than two decades. Many algorithms and methods of brain image processing and analysis have been reported, validated and are freely available, but ve | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $396,318 | Grant | Trans-NIH Recovery Act Research Support: The stated goal of LBRN project has been to establish a network to facilitate computational and biomedical research throughout the state. As a result of the BRIN and INBRE funding to the LBRN Program, Louisiana has successfully established the foundation | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $242,246 | Grant | Trans-NIH Recovery Act Research Support: SC IDEA NETWORK OF BIOMEDICAL RESEARCH EXCELLENCE The primary purpose of the SC INBRE program is to provide hands-on research experiences to undergraduate students and to serve as a pipeline to health research careers. The supplement will also allow expa | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $98,849 | Grant | Trans-NIH Recovery Act Research Support: Microstructural Heterogeneity of Membranes | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| UNIVERSITY OF MASSACHUSETTS | $97,877 | Grant | Trans-NIH Recovery Act Research Support: Rapid cell movement is important for the normal functioning of the immune system and for the spread of metastatic tumor cells. Migrating cells extend surface protrusions at their front edges, bind to the external matrix at focal adhesions, and then disas | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $221,311 | Grant | Trans-NIH Recovery Act Research Support: Title: Supplemental request for research technician and funds for state of the art instrument. An administrative supplement to R01 grant (GM34933) was awarded to facilitate our studies. The purpose of the supplement is to accelerate several screens for sp | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $265,705 | Grant | Trans-NIH Recovery Act Research Support: Appropriate expression and regulation of imprinted genes is critical for normal development, with mistakes in imprinted gene expression involved in a number of syndromes and cancer. This application will study the regulation of the H19 and Igf2 locus. Err | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $258,515 | Grant | Trans-NIH Recovery Act Research Support: The single-polypeptide RNA polymerase of the T7 bacteriophage has been a model system for studying fundamental mechanisms of transcription ever since it was first identified almost 4 decades ago. Work over the past 15 years has revealed that the functions | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $167,022 | Grant | Trans-NIH Recovery Act Research Support: This ARRA Supplement, R01-GM053034-13S1, is entitled !Biogenesis of Small Ribonucleoproteins.! One of the goals of the parent grant is to explore a novel role for a group of RNA-binding factors known as !Sm proteins! in germ cell development. During the c | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| BAYLOR COLLEGE OF MEDICINE | $242,962 | Grant | Trans-NIH Recovery Act Research Support: Special mechanisms of mutation are induced in bacteria and yeasts under growth-limiting stress causing genetic instability, and occasionally, adaptive mutations that may speed evolution. These stress-induced mutation mechanisms may provide superior models | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $209,894 | Grant | Trans-NIH Recovery Act Research Support: Patients with acute coronary syndromes (ACS) who are diagnosed with major depression are at greater risk for subsequent major adverse coronary events (MACE). Major depression is associated with increased inflammatory protein levels, but only in certain in | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| TRUSTEES OF THE UNVERSITY OF PENNSYLVANIA | $111,983 | Grant | Trans-NIH Recovery Act Research Support: This is a proposal for an administrative supplement to my parent grant NS17910, to extend our studies of electrical excitability in vivo to an investigation of the role of an ion channel regulatory protein complex in synaptic transmission. It supports th | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $32,561 | Grant | Trans-NIH Recovery Act Research Support: This grant supplement to NS29967 provided summer research experiences for two undergraduate students Kiauntee Murray (Brown University) and Kristen Miller (Vanderbilt University) in health related scientific research. This grant contributes to our basic u | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $150,674 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to develop a multiple channel peripheral nerve electrode capable of selective detection of fascicular nerve activity. This goal will be accomplished with four specific aims: Aim 1: Forward model of the nerve cuff interface. Aim | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $51,189 | Grant | Trans-NIH Recovery Act Research Support: The gastrointestinal epithelium is one of the most proliferative/regenerative tissues in adult organisms pointing to the existence of an intestinal stem cell (ISC) pool. Progress towards identification, isolation, and study of a self-renewing, multipotent | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $189,652 | Grant | Trans-NIH Recovery Act Research Support: Post-menopausal women are especially vulnerable to ischemic insult, and ~80,000 more cardiovascular deaths occur yearly in aged women than in aged men. Conflicting data exist on the role of estrogen (E2) in modulating ischemic tolerance (IT), due in part | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| NEW YORK UNIVERSITY (INC) | $331,071 | Grant | Trans-NIH Recovery Act Research Support: Title: BARTH SYNDROME: A MODEL FOR INVESTIGATING THE ROLE OF CARDIOLIPIN IN MITOCHONDRIA Barth syndrome is an X-linked disorder caused by mutations in the TAZ gene whose protein products, tafazzins, are phospholipid transacylases. The phospholipid mo | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $291,699 | Grant | Trans-NIH Recovery Act Research Support: Cardiovascular disease (CVD), which includes arterial occlusive disease (AOD), is the primary cause of mortality and morbidity in the United States. Aging is a major risk factor for CVD, thus a rapidly increasing aged population will result in markedly in | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF FLORIDA | $176,425 | Grant | Trans-NIH Recovery Act Research Support: A detailed understanding of the important interaction between hemodynamics and vascular remodeling has been limited by the non-linear relationships between these elements that regulate this process. To this end, we have initiated a systems-based analysis | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| RENSSELAER POLYTECHNIC INSTITUTE | $224,092 | Grant | Trans-NIH Recovery Act Research Support: To develop computational tools for modeling the respiratory deformation in the lungs using polygonal meshes, and to perform Monte Carlo radiation transport simulations and dose calculations in patients phantom efficiently. | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $284,850 | Grant | Trans-NIH Recovery Act Research Support: This competitive revision application extends from MH051699, Receptor-mediated lysophosphatidic acid (LPA) signaling in cortical development that is focused on LPA signaling as a novel, lipid influence on cerebral cortical development. It is responsive to | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $279,566 | Grant | Trans-NIH Recovery Act Research Support: This Administrative Supplement to our NIMH grant (2R01MH065252-08 - The Neural Basis of Categories) is for the topic of Enhancing Research Grants and Capacities through Infrastructure Support. Our NIMH-funded project examines a foundation of cognition: t | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $1,022,289 | Grant | Trans-NIH Recovery Act Research Support: This proposal responds to NOT-OD-09-058, Recovery Act Funds for Competitive Revision Applications. This revision application will support new research aims that are outside the scope of the currently funded parent grant, Infants at Risk of Autism: A Longi | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $44,378 | Grant | Trans-NIH Recovery Act Research Support: A disorder of thought and language has long been considered a core feature of schizophrenia. The broad objective of this proposal is to identify abnormalities in the neural dynamics of language processing in schizophrenia using multimodal imaging techniqu | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| RAND CORPORATION, THE | $1,875,500 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Underserved communities of color face an excess burden of illness from depression, due to the high prevalence of depression coupled with lower access to quality care among the poor. While evidence-based quality improve | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $226,876 | Grant | Trans-NIH Recovery Act Research Support: Our goal is to understand the assembly of a model, non enveloped virus that is extremely accessible to the methods of biophysics and molecular genetics. Specifically we are interested in how the viral genome is replicated with the enzyme that the virus en | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WASHINGTON UNIVERSITY, THE | $578,831 | Grant | Trans-NIH Recovery Act Research Support: Sepsis is the leading cause of death in most intensive care units with over 210,000 people succumbing tooverwhelming infection (or the resultant multiple organ failure) in the United States annually. A recentepidemiologic study estimated that 750,000 peop | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $127,204 | Grant | Trans-NIH Recovery Act Research Support: This project is focused on the response regulator component of two-component signaling sytems. These systems are the most prevalent multi-step signaling pathways in bacteria, with over 50,000 two-componet proteins identified to date. This project will f | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $228,681 | Grant | Trans-NIH Recovery Act Research Support: Plants and animals respond to PAMPs (pathogen-associated molecular patterns) that are indicative of pathogens. Oligogalacturonides (OGs), plant cell wall fragments generated by pathogen polygalacturonases, function as a PAMP in Arabidopsis thaliana. We hy | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $153,456 | Grant | Trans-NIH Recovery Act Research Support: The overall objective of this proposal is to examine the molecular mechanism(s) involved in the regulation of ovarian function by leuteinizing hormone (LH). The initial event is the interaction of LH with a specific receptor on the ovarian cell surface. T | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $141,405 | Grant | Trans-NIH Recovery Act Research Support: The hormone prolactin (PRL) in combination with the steroidal and neuropeptidergic changes accompanying pregnancy stimulate the onset of maternal care. The actions of PRL have been clearly demonstrated in studies in the rat. Direct infusions of PRL into | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| VISTA ENGINEERING, INC. | $10,000 | Grant | Trans-NIH Recovery Act Research Support: Temporomandibular Disorders (TMD) usually represent a collection of medical and dental conditions affecting the temporomandibular joint (TMJ) and/or the muscles of mastication, as well as contiguous tissue structures. For some patients with severe TMJ deg | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| COLUMBUS NANOWORKS, INC. | $200,000 | Grant | Trans-NIH Recovery Act Research Support: Columbus NanoWorks (CNW) proposes research leading to the commercialization of custom magnetic nanoparticle reagents for the detection of cancer cells from various sources such as bone marrow and peripheral blood. We will develop magnetic reagent kits as | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| EYERX RESEARCH, INC. | $25,450 | Grant | Trans-NIH Recovery Act Research Support: Dry eye is a ubiquitous, often overlooked, under diagnosed and poorly understood affliction of the ocular surface. As a multifactorial disease, dry eye has hyposecretory, auto-immune, inflammatory, hormonal, neurogenic, and iatrogenic components. Common t | Health and Human Services, Department of / National Institutes of Health | 7/10/2009 |
| FLUOROUS TECHNOLOGIES, INC | $495,644 | Grant | Trans-NIH Recovery Act Research Support: Project Title: Fluorous Solution-Phase Synthesis of Peptides and Oligosaccharides. This Administrative supplement seeks to expand upon the Specific Aims of the original grant by enabling: 1) Continued development of synthetic methods for fluorous peptide | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF FLORIDA | $149,635 | Grant | Trans-NIH Recovery Act Research Support: This is a new application in response to RFA-GM-04-002, for which the proposed work should help move toward the long-term goal of selection of antihypertensive drug therapy based on a patient's genetic make-up. Hypertension (HTN) is the most common chroni | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $89,115 | Grant | Trans-NIH Recovery Act Research Support: The fusion of sperm and egg lead to the combination of the father's and mother's genetic information to create a new individual. In humans, as in all mammals, sperm must reach the egg, penetrate its protective coat, fuse with the oocyte membrane, and deli | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $140,584 | Grant | Trans-NIH Recovery Act Research Support: This proposal seeks to continue funding for the TRIGR (Trial to Reduce IDDM in the Genetically at Risk) Data Management Unit (DMU). Established in 2002, the DMU at the University of South Florida was initially funded by a two-year start-up grant from the | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $489,147 | Grant | Trans-NIH Recovery Act Research Support: NHGRI is developing a research program to identify and characterize genetic variants causally associated with complex human diseases in genome-wide association (GWA) and other genetic studies. To support the complexities of such an ambitious effort, the D | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BROAD INSTITUTE, INC., THE | $4,804,686 | Grant | Trans-NIH Recovery Act Research Support: The 1000 Genomes Project is developing data resources and analytical methods required for the next stage of human genetics research: (a) discovering millions of novel polymorphisms with frequencies 0.5%-10%, which can then be tested for association to dis | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| ALASKA NATIVE TRIBAL HEALTH CONSORTIUM INC | $530,223 | Grant | Trans-NIH Recovery Act Research Support: This supplement allowed development & implementation of the Alaska Native Stroke Registry behavioral risk survey instrument, per the intended purpose of the grant award. Better understanding behavioral risk factors for stroke will allow researchers to de | Health and Human Services, Department of / National Institutes of Health | 8/18/2009 |
| GEORGIA TECH RESEARCH CORPORATION | $30,900 | Grant | Trans-NIH Recovery Act Research Support: Our overall goals are to: (1) coordinate investigations of South Pacific organisms as pharmaceutical resources for treating diseases of importance in the Pacific Islands and United States and for novel bioenergy applications (2) support sustainable uses o | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| FRONTIER SCIENCE & TECHNOLOGY RESEARCH FOUNDATION, INC. | $267,561 | Grant | Trans-NIH Recovery Act Research Support: One of the responsibilities of the Eastern Cooperative Oncology Group (ECOG) Operations Office is to coordinate correlative study development, which is done by working closely with ECOG Core Laboratories. ECOGG??s Leukemia Translational Research Laborato | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $262,494 | Grant | Trans-NIH Recovery Act Research Support: The recent advances in our understanding of the molecular basis for a broad range of pediatric diseases, coupled with the legislative changes culminating in the Best Pharmaceuticals for Children Act, has dramatically increased the potential for defining n | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $153,000 | Grant | Trans-NIH Recovery Act Research Support: The University of Texas Medical Branch (UTMB) has the capability to participate actively as a member of the Obstetric-Fetal Pharmacology Research Units (OPRU) Network. Gary Hankins, MD, as PI, is responsible for the proposed clinical trial on the use of h | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RESEARCH FOUNDATION FOR MENTAL HYGIENE INC | $233,082 | Grant | Trans-NIH Recovery Act Research Support: This supplement will enable the investigative team on the parent project to facilitate the entrance of a new PhD in Speech Pathology into the research pipeline. This new resource will enable the parent project to expand the data collection on the effects | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $53,978 | Grant | Trans-NIH Recovery Act Research Support: Dr. Yaakov Nahmias is a current Instructor in Surgery and Bioengineering at Harvard Medical School and seeks to establish himself as an independent investigator in the fields of regenerative medicine and BioMEMS. To that end, Dr. Nahmias submits this five | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $53,088 | Grant | Trans-NIH Recovery Act Research Support: The candidate is an epidemiologist and biostatistician with 10 years experience in conducting population-based observational studies. The application describes a 3-year career development plan that will provide the candidate with the formal training and l | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $108,000 | Grant | Trans-NIH Recovery Act Research Support: This two-year administrative supplement directly complements the research activities included in Dr. MarshG??s Mentored Research Scientist Development Award (MRSDA). The overall aim of her original research project is to understand how disturbances in the | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $49,238 | Grant | Trans-NIH Recovery Act Research Support: The candidate's main objective is to establish a vigorous, independent research program centered on structure and function studies of HIV replication complexes. The new findings will be exploited to discover novel effective antiretroviral inhibitors. Sinc | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| RHODE ISLAND HOSPITAL | $49,152 | Grant | Trans-NIH Recovery Act Research Support: The World Health Organization estimates that nearly half of pregnant women worldwide suffer from anemia, with 52% residing in lesser-developed countries (LDCs) and 23% in industrialized nations. Anemia is recognized as a major cause of low birth weight (L | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $106,359 | Grant | Trans-NIH Recovery Act Research Support: Dr. Badr's K07 research plan is devoted to the implementation of a multi-method prospective study of the effects of spousal communication on cognitive procesing and adjustment to head and neck cancer (HNC). Infusion of ARRA funds in Years 2 and 3 of Dr. B | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $99,992 | Grant | Trans-NIH Recovery Act Research Support: This award is issued in response to Notice OD-09-060, Recovery Act Administrative Supplements Providing Summer Research Experiences for Students and Science Educators.DESCRIPTION (provided by applicant): This proposal envisions a comprehensive plan for th | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| MONTEFIORE MEDICAL CENTER | $107,920 | Grant | Trans-NIH Recovery Act Research Support: Enhance the scientific tempo of experiments proposed in K-08 by use of sophisticated state of the art technology including analysis of body composition using qMR and use of expression chip to analyze hundreds of coordinated changes in adipose tissue and m | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY | $49,011 | Grant | Trans-NIH Recovery Act Research Support: This research proposal is based on the clinical observation that a small number of potential allergens that humans encounter account for the large majority of allergic responses. The immune system's sentinel cells, dendritic cells (DC), play a crucial rol | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $50,000 | Grant | Trans-NIH Recovery Act Research Support: Severe acute respiratory syndrome (SARS), caused by a new human coronavirus (SARS-CoV), represents the 21st century's first pandemic caused by a previously unknown etiological agent. The 2002-03 SARS epidemic stimulated research on coronaviruses of humans | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| COLORADO STATE UNIVERSITY | $108,000 | Grant | Trans-NIH Recovery Act Research Support: proposal is presented for the formal training of a veterinary surgeon in the molecular and genetic aspects of cartilage repair. The candidate is board certified with the American College of Veterinary Medicine, and possesses a Master of Science in Pharmac | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $136,565 | Grant | Trans-NIH Recovery Act Research Support: The Fbw7 ubiquitin ligase is central to the negative regulation of a number of growth promoting proteins. A central goal of my K08 proposal is to utilize mouse models to understand how loss of Fbw7 contributes to colorectal tumorigenesis in vivo. As the u | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| WASHINGTON UNIVERSITY, THE | $108,000 | Grant | Trans-NIH Recovery Act Research Support: While therapeutic advances have led to an improvement in survival for many types of malignancies, survival for patients diagnosed with lung cancer or pulmonary metastatic disease remains grim. Development of novel therapeutic strategies is necessary in o | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $49,680 | Grant | Trans-NIH Recovery Act Research Support: Hepatic stellate cells (HSC) are at the center of liver fibrogenesis. When activated, they produce profibrogenic cytokines, including transforming growth factor +? (TGF-+?), and deposit extracellular matrix. We have recently demonstrated a novel fibroge | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $108,000 | Grant | Trans-NIH Recovery Act Research Support: This proposal will investigate how cells of the respiratory tract sense and attack disease causing bacteria that attempt to steal iron for their growth. The goals of the supplement are to identify targets of Lcn2 dependent gene activation by 1) cultured | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $54,000 | Grant | Trans-NIH Recovery Act Research Support: Studies utilizing modern neuroimaging techniques have provided clear evidence that the adolescent brain is actively developing. This neurodevelopment, particularly in the frontal lobes, coincides with improvements in several areas of higher order cognitiv | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| NEW YORK UNIVERSITY (INC) | $99,997 | Grant | Trans-NIH Recovery Act Research Support: Investigation of the function of the regulation of ERK3 The long term objectives of this research proposal are to lay the foundation for future investigation of the role of ERK3 in carcinogenesis and development. This research supplement application is d | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| DUKE UNIVERSITY | $46,529 | Grant | Trans-NIH Recovery Act Research Support: Obesity prevention among Black women is a major public health priority. At present, nearly 54% of the adult Black female population (aged 20 and older) is obese. The group also suffers disproportionately from obesity-related health consequences (e.g. many | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $96,768 | Grant | Trans-NIH Recovery Act Research Support: Faulty regulation of apoptosis and the cell cycle are critical determinants of cancer pathogenesis. These essential cellular processes are modulated, in health and disease, by multiple protein networks. Among these, the BCL-2 family of pro- and anti-apopt | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $11,880 | Grant | Trans-NIH Recovery Act Research Support: This career transition award will provide the candidate with the opportunity to investigate new areas of research: mechanotransduction and mechanical stimulation for regenerating condylar cartilage of the temporomandibular joint (TMJ). The environment in | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| UNIVERSITY OF ILLINOIS | $9,288 | Grant | Trans-NIH Recovery Act Research Support: This award was intended as a supplement to a K22 career development award. The award intended to allow the PI to hire two dental students to conduct research as part of a College-wide student summer research program. The purpose of the award was to help t | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $50,000 | Grant | Trans-NIH Recovery Act Research Support: In accordance with the objectives of the American Recovery and Reinvestment Act of 2009 (ARRA) Administrative Supplements, this supplement application will: 1) promote new job creation, and 2) accelerate both the tempo and the achievement of research. Sup | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| SEATTLE CHILDREN'S HOSPITAL | $53,967 | Grant | Trans-NIH Recovery Act Research Support: Renal transplant and subclinical herpesvirus infection -- Chronic allograft nephropathy (CAN) is the major barrier to long-term graft survival. The more potent immunosuppressive therapy that has successfully reduced the incidence of acute rejecti | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| TUFTS MEDICAL CENTER, INC. | $54,000 | Grant | Trans-NIH Recovery Act Research Support: Chronic kidney disease is an important health care problem in the elderly The normal level of kidney function with age as well as accuracy of kidney function estimates in the general population are unknown. This gap in knowledge limits investigation of | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $108,000 | Grant | Trans-NIH Recovery Act Research Support: This application proposes a training plan to develop Laura E. Dreer, PhD into an independent patient-oriented researcher specializing in investigations of psychological-based treatment interventions for persons with low vision. Dr. Dreer is a licensed cli | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $219,751 | Grant | Trans-NIH Recovery Act Research Support: This is an Application for Supplemental Funding that will very significantly accelerate progress on the central objectives of P01HD037105-11A1. In its specific scientific objectives and in its practical aspects this request is directly in accord with the | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| MAGEE-WOMENS HEALTH CORPORATION | $11,139 | Grant | Trans-NIH Recovery Act Research Support: This Program Project addresses among the most important questions in stem cell medicine and biology through responsible studies on the potentials of pluripotent stem cells from humans (hESC) and nonhuman primates (nhpESC) during development in vitro and i | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF ILLINOIS | $14,997 | Grant | Trans-NIH Recovery Act Research Support: The award provided salary and supply support for a summer student, David Lewandowsi, an outstanding pre-medical student at University of Illinois Urbana Champaign. David analyzed hearts isolated from transgenic mice by determining the changes associated | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $190,848 | Grant | Trans-NIH Recovery Act Research Support: We propose to develop an eight-week long summer program in the neurosciences, called the Summer Undergraduate Neuroscience (SUN) Program, based at the Louisiana State University Health Sciences Center, Neurosciene Center of Excellence. This program will o | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF LOUISVILLE | $759,342 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this funding is to ensure that the lead compounds identified by the MT-COBRE cancer researchers undergo sufficient optimization and early pre-clinical testing to warrant pharmaceutical consideration for Phase I clinical trials testing. | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| OKLAHOMA MEDICAL RESEARCH FOUNDATION | $995,065 | Grant | Trans-NIH Recovery Act Research Support: The Oklahoma Medical Research Foundation is grateful to house a Center for Biomedical Research Excellence (COBRE) with a scientific theme of molecular and genetic mechanisms of autoimmunity. Key components include four junior investigator projects, one r | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| DUKE UNIVERSITY | $438,566 | Grant | Trans-NIH Recovery Act Research Support: Understanding the relationships between visuospatial and mathematical processing is an important public health challenge. Our research goal is to determine the functional contributions of different parts of the parietal cortex to the extraction of numeric | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| LUDWIG INSTITUTE FOR CANCER | $162,658 | Grant | Trans-NIH Recovery Act Research Support: The essential function of mitosis is the delivery of a complete set of chromosomes to each daughter cell. This requires attachment of spindle microtubules to kinetochores, specialized structures formed at centromeres. Kinetochores are more than just struc | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $785,157 | Grant | Trans-NIH Recovery Act Research Support: The objective of this collaborative and synergistic program is to determine how interactions between immigrant neutrophils and macrophages and resident synovial fibroblasts lead to the formation of synovial pannus and joint destruction. Preliminary result | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $867,370 | Grant | Trans-NIH Recovery Act Research Support: The funds are provided to assist in the development of Mutagenetix, a web site for the display, documentation, and in-house organization of work related to ENU mutagenesis in the mouse. This site has so far been designed without specific financial assista | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $252,503 | Grant | Trans-NIH Recovery Act Research Support: This award provides funds to finance the implementation of a dedicated four node IQ36000x cluster Isilon digital data storage and backup system to manage and protect vital digital data generated in the Intravital Microscopy Core (Core B) of our Program Pr | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $245,036 | Grant | Trans-NIH Recovery Act Research Support: Herpes Oncogenesis, Latency, And Reactivation (ARRA) Project Title: !Herpesvirus Oncogenesis, Latency, and Reactivation! The Parent Program Project focuses on interactions between viral and cellular proteins in herpesvirus infection. This Administrativ | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $192,026 | Grant | Trans-NIH Recovery Act Research Support: Paradigm-shifting observations on aquaporin 2 (AQP2) and vasopressin receptor (V2R) trafficking, and vacuolar ATPase (V-ATPase) pH sensing and recycling have lead to new hypotheses to be addressed in this renewal. Project I will define VP-dependent and in | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $250,901 | Grant | Trans-NIH Recovery Act Research Support: PROJECT SUMMARY (See instructions): There are four separate requests contained within this Administrative Supplement (one for each investigator and one for the Cell Biology Core). The most significant portion of the budget is devoted to the purchase of t | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| WASHINGTON UNIVERSITY, THE | $300,001 | Grant | Trans-NIH Recovery Act Research Support: Our 'metagenome' is a composite of H. sapiens genes and genes present in the genomes of the trillions of microbes that colonize our adult bodies. 'Our' microbial genomes (microbiome) encode metabolic functions we have not had to evolve on our own, but rem | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| THE VANDERBILT UNIVERSITY | $386,449 | Grant | Trans-NIH Recovery Act Research Support: Administrative Supplement funding is requested to advance the pace of scientific progress in our investigation of the cellular effects of membrane-bound and diffusible electrophilic lipid oxidation products. Together with our Program Project colleagues w | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| DREXEL UNIVERSITY | $519,761 | Grant | Trans-NIH Recovery Act Research Support: The overall goal in this program project is to understand the potential of ligands of the human immunodeficiency virus (HIV-1) gp120 envelope glycoprotein to inhibit virus entry. This Administrative supplement is submitted in response to NOT-OD-09-056: N | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC. | $580,470 | Grant | Trans-NIH Recovery Act Research Support: The lifespan of adults with intellectual disability has been dramatically extended during the second half of the Twentieth Century. Advances in medicine, public health, early intervention, nutrition and habilitative technologies have contributed to this | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF SOUTH ALABAMA | $16,202 | Grant | Trans-NIH Recovery Act Research Support: THIS APPLICATION SEEKS SUPPORT FOR SUMMER STIPENDS FOR TWO UNDERGRADUATE AND TWO HIGH SCHOOL STUDENTS WORKING WITH PROJECT LEADERS OF OUR PROGRAM PROJECT GRANT, ENTITLED LUNG ENDOTHELIAL PHENOTYPES (HL66299). PROJECT LEADERS INCLUDE DRS. TROY STEVENS, MA | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $94,018 | Grant | Trans-NIH Recovery Act Research Support: We demonstrated previously that myotonic dystrophy type 2 (DM2) is caused by a CCTG expansion in intron 1 of the ZA/F9gene. Parallels between the DM1 and DM2 expansion mutations and the characterization of RNA binding proteins that interact with expanded | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $256,993 | Grant | Trans-NIH Recovery Act Research Support: Alcoholic liver disease remains a highly prevalent and often lethal complication of alcohol abuse, whose etiology is incompletely understood. Understanding the basis of alcoholic liver disease could improve the health of millions of Americans afflicted by | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| KAISER FOUNDATION HOSPITALS | $184,501 | Grant | Trans-NIH Recovery Act Research Support: It is now widely recognized that the mere existence of scientific knowledge is not sufficient for it subsequent application. Active dissemination methods are necessary to increase the effectiveness of dissemination efforts. Given the stated priorities a | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| FOX CHASE CANCER CENTER | $325,205 | Grant | Trans-NIH Recovery Act Research Support: Lincoln University ? Fox Chase Partnership in Cancer Research and Training A P20 partnership was established between Fox Chase Cancer Center (FCCC) and Lincoln University (LU) Pennsylvania to train Lincoln students and faculty in cancer research, health | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $309,176 | Grant | Trans-NIH Recovery Act Research Support: This project is in association with the parent grant to launch the Schizophrenia Research Center at Johns Hopkins, in response to PAR-07-434 Silvio O. Conte Center to develop collaborative research in neuroscience of mental disorders (P20). The overall go | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| CHARLES DREW UNIVERSITY OF MEDICINE AND SCIENCE | $169,968 | Grant | Trans-NIH Recovery Act Research Support: This supplement has assisted Charles Drew University of Medicine and Science (CDU) to expand the institution?s mission of developing future investigators from disadvantaged backgrounds and vulnerable populations through mentoring opportunities: (1) resear | Health and Human Services, Department of / National Institutes of Health | 7/10/2009 |
| OKLAHOMA MEDICAL RESEARCH FOUNDATION | $300,000 | Grant | Trans-NIH Recovery Act Research Support: Science in a Culture of Mentoring Collaborative Community Engagement Research - Rheumatic diseases significantly impact the health and well-being of a large portion of the population. This proposal seeks to enroll healthy individuals from diverse backgrou | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF HAWAII SYSTEMS | $934,610 | Grant | Trans-NIH Recovery Act Research Support: COBRE: Center for Cardiovascular Research We are submitting this renewal application for the Center of Biomedical Research Excellence (COBRE) at the University of Hawaii (UH) in response to the National Institutes of Health RFA-RR-06-001. The John A. Burn | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| MONTANA STATE UNIVERSITY, INC | $536,586 | Grant | Trans-NIH Recovery Act Research Support: Montana INBRE established a multidisciplinary, statewide network with the goal of positioning Montana as a national leader in research on the pathogenesis of infectious diseases and on the increasing health issues related to the environment, while develop | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $292,900 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Leukocyte regulatory receptors (LRRs) effect a variety of immune functions, including self/nonself recognition and fine regulation of the response to infection. Membrane receptors belonging to several different LRR gen | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| COLORADO STATE UNIVERSITY | $150,000 | Grant | Trans-NIH Recovery Act Research Support: Public Health Relevance: Tuberculosis is one of the most important diseases in the world. As recently emphasized by an NIAID document, virtually nothing is known about the host response to, and basic biology of, the rapidly spreading epidemic of MDR stra | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $39,440 | Grant | Trans-NIH Recovery Act Research Support: Human CD21 is an innate immune system receptor (C3dg receptor or complement receptor type 2, CR2) and is a key modulator of the acquired immune response. CD21 is also the high affinity receptor for EBV. CD21 plays a direct role in the pathogenesis of a br | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| UNIVERSITY OF PITTSBURGH THE | $111,883 | Grant | Trans-NIH Recovery Act Research Support: It has been demonstrated by our studies, and the work of others, that prolonged in vivo or ex vivo exposure of murine myeloid dendritic cells (mDC) to rapamycin (RAPA) confers resistance to phenotypic (CD86 upregulation) and functional maturation (increa | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $38,048 | Grant | Trans-NIH Recovery Act Research Support: The focus of our current studies has been to determine the role of transcription factor IRF-5 in the antiviral and inflammatory responses to virus infection and TLR ligands. To this effect we have analyzed IFN and cytokine levels in Irf5-/- mice and obser | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| CORNELL UNIVERSITY, INC | $165,770 | Grant | Trans-NIH Recovery Act Research Support: The overall aim is to investigate the molecular and neurophysiological mechanisms for steroid-dependent plasticity of auditory encoding in a teleost fish model system. Aim 1 of the parent grant tests the hypothesis that estrogen-dependent shifts in audito | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $39,749 | Grant | Trans-NIH Recovery Act Research Support: Physiology of Dorsal Cochlear Nucleus Molecular Layer ARRA This supplement requested equipment to accelerate our research productivity on this grant in two ways, under the ?Research Equipment for the Advancement of Science?. The first is by replacing a s | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $65,984 | Grant | Trans-NIH Recovery Act Research Support: Two aims are proposed. Aim 1. Test the hypothesis that centrifugal noradrenergic modulation of olfactory bulb function is necessary for discrimination of closely related odors. Aim 2. Test the hypothesis that noradrenaline modulates cellular properties a | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $148,632 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Sound stimuli are converted into electrical signals in hair cells of the inner ear by activation of mechanically-sensitive transducer channels in the stereociliary membrane. Compared with other types of ion channel, li | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $122,602 | Grant | Trans-NIH Recovery Act Research Support: The gut-associated lymphoid tissue must manage a tedious balance between physiologic and tissue destructive inflammation associated acutely with exposure to pathogens and other exogenous assaults and chronically in the setting of the idiopathic types of i | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE | $33,881 | Grant | Trans-NIH Recovery Act Research Support: We are requesting an administrative supplement to our parent grant in order to hire three undergraduates students during Summer 2009 and 2010. One student, Jake Schnabl, has been in the PI?s lab since August 2006. He is currently a junior at UC Riverside | Health and Human Services, Department of / National Institutes of Health | 6/22/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $13,230 | Grant | Trans-NIH Recovery Act Research Support: Alternative splicing of pre-mRNA transcripts is a widespread means for producing polypeptide diversity from a single gene. Over 60% of human genes are expressed through alternative splicing, however, mechanisms of splicing regulation are poorly understood | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $18,008 | Grant | Trans-NIH Recovery Act Research Support: Award Title: NIDDK Program for Administrative Supplements Utilizing Recovery Act Funds: Summer Student Research Experiences for Students and Science Educators (NOT-OD-09-05). Parent Grant # & Title: 2 R01 DK 054452: Macrophage Gene Expression in Mucosal I | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BAYLOR COLLEGE OF MEDICINE | $42,813 | Grant | Trans-NIH Recovery Act Research Support: The long-term objectives of this request for supplemental funding are to define the genetic, epigenetic, nutritional, and environmental factors that impact mammary gland development and function. With this supplemental grant we will use mRNA isolated from | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF WASHINGTON | $85,765 | Grant | Trans-NIH Recovery Act Research Support: This is an administrative supplement to R01 Cell Cycle and POdocyte Apoptosis, awarded for 4 years to define novel mechanisms underlying podocyte death. In this grant, we are testing the hypothesis that newly discovered cell cycle proteins called cyclin I | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF UTAH, THE | $97,825 | Grant | Trans-NIH Recovery Act Research Support: Project summary: Immune recovery after bone marrowtransplantation remains a significant clinical problem, one that may be addressed by progenitor cell transplants aimed at augmenting lymphoid recovery. Recent studies using clonal cultures and intrathymic | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $238,979 | Grant | Trans-NIH Recovery Act Research Support: The aim is to determine the contribution of mechanical factors (myofibroblast contractility and regional increases in liver stiffness) to the development of bridging fibrosis. The research plan includes 1) a detailed morphological analysis of fibrotic rat | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $111,099 | Grant | Trans-NIH Recovery Act Research Support: The goal of this research is to understand how cilia form and function. The nematode Caenorhabditis elegans is a powerful model system to study cilia biology. Many proteins that are required for formation, maintenance, and function of cilia in C. elegans | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $366,114 | Grant | Trans-NIH Recovery Act Research Support: Post-transcriptional regualtion of gene expression and the link between the translation elongation factor 1A (eEF1A) and the actin cytoskeleton and other actin associated proteins remains an area where little is known about mechanism or regulation. The o | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| CORNELL UNIVERSITY, INC | $119,577 | Grant | Trans-NIH Recovery Act Research Support: Cells have evolved mechanisms to establish spatial order of their constituent organelles and provide direction for transport of cellular components. This is most apparent in the need for cell polarity and the ability to segregate organelles appropriately | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| GEISINGER CLINIC | $90,642 | Grant | Trans-NIH Recovery Act Research Support: BETA/GAMMA SUBUNIT HETEROGENIETY IN G PROTEINS - The specificity of G protein signaling in brain is essential for the translation of neurotransmitter activity into meaningful neurological responses. The challenge is to understand how this is accomplished. | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| TUFTS MEDICAL CENTER PARENT, INC. | $65,190 | Grant | Trans-NIH Recovery Act Research Support: The award allowed the hiring of undergraduate student Erica Milia who worked on experiments under the PI's project investigating the mechanism of hypoxia-induced pulmonary edema. Ms. Milia worked on testing the effect of agents that inhibit p38 signaling | Health and Human Services, Department of / National Institutes of Health | 5/28/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $243,513 | Grant | Trans-NIH Recovery Act Research Support: This Supplement Proposal is aimed to enhance the research outcome of the parent award entitled Smad2 and smooth muscle cell differentiation from neural crest cells. Abnormality of vascular smooth muscle cell (VSMC) differentiation contributes to a number | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| MEHARRY MEDICAL COLLEGE | $162,908 | Grant | Trans-NIH Recovery Act Research Support: This supplement provides funds to hire a postdoctoral scientist in cancer biology. The goal of the project the postdoc is working on is to understand the nature of the interaction between fetuin-A and annexin-6. These are two molecules that affect calciu | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF TEXAS AT SAN ANTONIO | $125,416 | Grant | Trans-NIH Recovery Act Research Support: In educational settings students are often expected to learn the definitions of pairs of concepts (e.g., fluid and crystallized intelligence). For many students these concepts are difficult to learn because they have similar definitions that are easy to c | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| CHARLES DREW UNIVERSITY OF MEDICINE AND SCIENCE | $101,150 | Grant | Trans-NIH Recovery Act Research Support: Recent evidence demonstrates that the functional impairment or atrophy of pelvic muscles, such as levator ani, urethral supports and urethral sphincter, are responsible for stress urinary incontinence (SUI) in women. SUI is a common condition with signifi | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| CHARLES DREW UNIVERSITY OF MEDICINE AND SCIENCE | $96,575 | Grant | Trans-NIH Recovery Act Research Support: In the United States, the reported rates of new HIV diagnoses among black and Hispanic women are, respectively, 20 and 5.4 times that of white women. A greater tendency toward bisexual behavior and non-gay identification among black and Hispanic men who h | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $749,121 | Grant | Trans-NIH Recovery Act Research Support: The need for new therapies in relapsed or refractory acute myeloid leukemia (AML) is unquestioned. So far, the CD33-targeting immunoconjugate, gemtuzumab ozogamicin (GO), remains the only FDA-approved drug for this group of patients. However, since GO has | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF NEW MEXICO | $278,627 | Grant | Trans-NIH Recovery Act Research Support: The Cancer Epidemiology and Prevention Program was formally established in 1973 when the New Mexico Tumor Registry joined with 6 other population-based tumor registries to form the NCI-SEER (Surveillance, Epidemiology and End Results) program. The NM SEER | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| UNIVERSITY OF MARYLAND | $150,000 | Grant | Trans-NIH Recovery Act Research Support: The mission of the University of Maryland Marlene and Stewart Greenebaum Cancer Center is to undertake innovative basic and clinical research which will impact the understanding and treatment of cancer around the world and to provide state-of-the-art clin | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| HOUSE EAR INSTITUTE INC | $136,425 | Grant | Trans-NIH Recovery Act Research Support: In this supplement, we aim to accelerate scientific progress and expand the service of the parent P-30 grant through design, construction, configuration and calibration of an apparatus for screening and evaluating hearing in small rodents. Expansion of En | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CHICAGO, THE | $300,000 | Grant | Trans-NIH Recovery Act Research Support: The objectives of the University of Chicago's DDRCC remain 1) to foster digestive diseases-related research in IBD in a supportive, integrative, collaborative and multidisciplinary manner; 2) to enhance the basic research capabilities of established diges | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $48,844 | Grant | Trans-NIH Recovery Act Research Support: This project will focus on research efforts related to mechanisms underlying migration and invasion by iesophageal epithelial cells; related to epithelial mesenchymal transition of esophageal epithelial cells; and related to the role of microRNAs and co | Health and Human Services, Department of / National Institutes of Health | 6/09/2009 |
| WASHINGTON UNIVERSITY, THE | $240,256 | Grant | Trans-NIH Recovery Act Research Support: This supplement will accelerate the tempo of building a comprehensive multidimensional discovery platform from which investigators can launch further hypothesis-driven studies on inflammatory bowel diseases pathogenesis. It will advance the objectives of | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $299,999 | Grant | Trans-NIH Recovery Act Research Support: 1) Hire a molecular biologist research associate (RA) to produce targeting contracts and screening ES cells. The duties of this person will include retrieval of targeting vector from BAC genomic DNA, insertion of lox P sites and fRT-flanked PGK-neo elect | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $204,401 | Grant | Trans-NIH Recovery Act Research Support: Monitoring is a periodic measurement that guides the management of a chronic or recurrent condition. It aims to detect departure from the conditions baseline, establish the response to treatment, and detect the need to adjust treatment. Our goal is to ide | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF PITTSBURGH THE | $236,839 | Grant | Trans-NIH Recovery Act Research Support: The objective of the Pittsburgh Center for Kidney Research is to both reinforce and expand interactions among investigators at the University of Pittsburgh and colleagues at Mount Sinai School of Medicine who have had a longstanding history of research in | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| OREGON STATE UNIVERSITY | $714,918 | Grant | Trans-NIH Recovery Act Research Support: The Environmental Health Sciences (EHS) Center at Oregon State University is an interdisciplinary unit of 35 Center investigators and now in its 39th year of existence. The mission of the EHS Center is to foster excellent research and technology developme | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $339,831 | Grant | Trans-NIH Recovery Act Research Support: This supplement will support a collaborative project between the P30-funded Intellectual and Developmental Disabilities Research Centers (IDDRCs) in Wisconsin (P30HD003352, Marsha Mailick Seltzer, PI) and North Carolina (P30HD003110, Joseph Piven, PI). Th | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $304,885 | Grant | Trans-NIH Recovery Act Research Support: This application seeks core support from the Mental Retardation/Developmental Disabilities Branch of the National Institute of Child Health and Human Development for the Wisconsin Mental Retardation Developmental Disabilities Research Center (MRDDRC). The | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| BAYLOR COLLEGE OF MEDICINE | $399,941 | Grant | Trans-NIH Recovery Act Research Support: Purpose:The BCM-Emory Fragile X research center ARRA stimulus funds requested here will accelerate efforts to understand and treat these disorders through the study of patient symptoms and models of the diseases. Abstract: The BCM-Emory Fragile X Researc | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF CHICAGO, THE | $77,706 | Grant | Trans-NIH Recovery Act Research Support: This is an application for an administrative supplement to the J.P. Kennedy Intellectual and Developmental Disabilities Research Center (IDDRC) at The University of Chicago, which is about to begin its fourth year. We are requesting Seed Grant funds for | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| TEXAS A&M UNIVERSITY-KINGSVILLE | $209,149 | Grant | Trans-NIH Recovery Act Research Support: The Viper Resource Center (VRC), P40 competitive renewal, at Texas A&M University-Kingsville proposes to continue the aims of the initial grant application. The resources will be expanded and snake venom, venom fractions, blood and cells will be made avai | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CHICAGO, THE | $185,074 | Grant | Trans-NIH Recovery Act Research Support: We anticipate that the supplement will allow the Center to hire an additional post doctoral research associate. We are presently inquiring about availability of soon to graduate or relatively recent Engineering Ph. D.s with expertise in RF /Microwave desi | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $417,176 | Grant | Trans-NIH Recovery Act Research Support: This FlyBase administrative supplemental request addresses three issues facing FlyBase and other Model Organism Databases (MODs). First is the challenge of handling and integrating the growing number and diversity of large-scale data sets being produced b | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DUKE UNIVERSITY | $904,747 | Grant | Trans-NIH Recovery Act Research Support: The Duke Center for In Vivo Microscopy (CIVM) is an NCRR National Resource, now in our 19th year dedicated to the development of novel methods for small animal imaging and the application of those methods to important biomedical questions. We propose acce | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $1,285,619 | Grant | Trans-NIH Recovery Act Research Support: This application seeks support for a center of excellence in computational mass spectrometry and a national and international resource in the broad area of proteomics. It proposes to enlarge the current research activities, to branch into previously unexp | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| MCLEAN HOSPITAL CORPORATION, THE | $114,155 | Grant | Trans-NIH Recovery Act Research Support: This is an amended competitive continuation grant of the Udall Parkinson's Disease Research Center of Excellence at Harvard University and McLean Hospital, which is directed by Professor Ole Isacson. The Center performs scientific work on conceptually nov | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $400,000 | Grant | Trans-NIH Recovery Act Research Support: This NCRR ARRA supplement to the Tulane National Primate Research Center (TNPRC) provides two years of funding for pilot projects to support expansion of the highly successful Pilot Research Program at the TNPRC. The purpose of the Pilot Research Progra | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $244,254 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplemental submission to the California National Primate Research Center (CNPRC) Base Operating Grant is to enable large-scale sharing of existing nonhuman primate pathology data (histologic images, gross photos and associated biolo | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $28,214 | Grant | Trans-NIH Recovery Act Research Support: Harnessing Functional Genomics to Reveal Cancer Specific Determinants of Mitosis. This project will be centered around exploring mechanisms of action of a novel protein involved in tumorignenes, ACRBP. During the 12 week summer research program, t critica | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| THE VANDERBILT UNIVERSITY | $80,446 | Grant | Trans-NIH Recovery Act Research Support: The primary goal of this administrative supplement is to significantly increase the number of 15N hyperpolarized metabolic injectable agents based on parahydrogen hyperpolarization technology. Parahydrogen is a unique and stable molecule that can provide | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $127,204 | Grant | Trans-NIH Recovery Act Research Support: The parent grant is a double-blind study investigating the efficacy of cognitive behavioral therapy plus the agonist-like medication Lisdexamfetamine or placebo to treat cocaine dependence. There is a much greater-than-anticipated demand for this treatme | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $251,022 | Grant | Trans-NIH Recovery Act Research Support: Kidney Injury Molecule-1 (KIM-1) is a type 1 transmembrane protein that is not detectable in normal kidney tissue but is expressed at very high levels in dedifferentiated proximal tubule epithelial cells in human and rodent kidneys after ischemic or toxic | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| HEALTH RESEARCH, INC. | $244,324 | Grant | Trans-NIH Recovery Act Research Support: Understanding the Bacterial Ribosome assembly reaction is key to identifying potential new targets for the development of antibiotics. Molecular recognition by RNA is a key component of regulatory networks in living cells and therefore requires detailed b | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MASSACHUSETTS | $123,063 | Grant | Trans-NIH Recovery Act Research Support: This award, received in just the last 7-10 days, is for supplemental funds ($75,000 direct costs for one year) to support use of human iPS cells to study the fundamental aspects of X-chromosome inactivation in human females. The title of the parent R01 gr | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| LOYOLA UNIVERSITY | $33,171 | Grant | Trans-NIH Recovery Act Research Support: Injury remains the primary cause of death during the first four decades of life, outnumbering all other causes of death, including heart disease and cancer, and accounts for millions of disabling injuries per year at an annual cost of over $130 billion. T | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $46,325 | Grant | Trans-NIH Recovery Act Research Support: P2X receptors (P2XRs) constitute the most recently cloned superfamily of ligand-gated ion channels LGICs). P2XRs are fast acting, cation-permeable ion channels that are gated by synaptically released extracellular adenosine 5'-triphosphate (ATP) and are w | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| THE VANDERBILT UNIVERSITY | $28,948 | Grant | Trans-NIH Recovery Act Research Support: This request for an Administrative Supplement to the parent grant (5 R01 AA015752-03) entitled Intracellular Therapeutics for Inflammatory Liver Injury is responsive to NOT-OD-09-056 (NIH Announces the Availability of Recovery Act Funds for Administrative | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| THE WASHINGTON UNIVERSITY | $37,267 | Grant | Trans-NIH Recovery Act Research Support: Everyday face-to-face conversations often occur in the presence of adverse environmental conditions such as background noise and/or poor lighting. In this second stage of our research on audiovisual speech perception and aging, we turn our attention to co | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $72,609 | Grant | Trans-NIH Recovery Act Research Support: Decay accelerating factor (DAF) is a 70 kDa intrinsic membrane regulator that protects self cells from autologous complement-mediated injury. It functions by decaying the C3 central convertases (C4b2a and C3bBb), a process which determines whether complem | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $12,969 | Grant | Trans-NIH Recovery Act Research Support: The funding for this award was used to purchase an electronic component to upgrade a mass spectrometer in the University Mass Spectrometry Center. | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| DUKE UNIVERSITY | $5,585 | Grant | Trans-NIH Recovery Act Research Support: Cryptococcus neoformans is a fungal pathogen that causes meningitis in both immunocompromised and immunocempetent patients. The ability to grow at human physiological temperature is an essential virulence factor of C. neoformans, which is orchestrated by | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $373,460 | Grant | Trans-NIH Recovery Act Research Support: Our work to date has highlighted new and unexpected roles for Ikaros and its associate, the chromatin remodeler Mi-22 in fate decisions made by hematopoietic stem cells and their early multipotent progeny. We now propose to further evaluate the roles of I | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $90,087 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project is to gain further understanding of the mucosal immune system and the defects that contribute to the pathogenesis of human inflammatory bowel disease (IBD). The generation of a number of murine models of IBD has facilitate | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $314,823 | Grant | Trans-NIH Recovery Act Research Support: Allergic reactions to peanuts occur because susceptible individuals have an aberrant response to peanuts by producing a plasma protein, IgE, that binds to the high affinity receptor for IgE, FceRI, on mast cells and basophils. This IgE can be cross-linked | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF ROCHESTER | $92,803 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this administrative supplement is to provide funds for the hiring, training, and supply costs of an undergraduate student to expedite the accomplishment of Aim 2 which focuses on defining the consequences of BCDT and targeted biologic antag | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| BRANDEIS UNIVERSITY | $118,595 | Grant | Trans-NIH Recovery Act Research Support: During the replication of many viruses, hundreds to thousands of protein subunits assemble around the viral nucleic acid to form a protein shell called a capsid. Within their host organism, most viruses form one particular structure with astonishing fide | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| VETERANS MEDICAL RESEARCH FOUNDATION OF SAN DIEGO | $299,348 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement is a request for personnel to increase the tempo of research on the R01 grant 'HIV-1 Vpu and BST-2/CD317' by maintaining and increasing the current level of technical support and employment on this project. Specifically, our | Health and Human Services, Department of / National Institutes of Health | 9/12/2009 |
| NORTHWESTERN UNIVERSITY | $464,286 | Grant | Trans-NIH Recovery Act Research Support: This supplement fund will be used to support the parent grant in analysis. Also added personnel support for a Post-doctoral fellow and a new technician who will carry out the work. Also the supplement will be used to purchase equipment that will further i | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $1,063,933 | Grant | Trans-NIH Recovery Act Research Support: This competing supplement is awarded to add a new aim to the parent grant that will identify the neuronal circuit(s) affected by the hypothalamic expression of Delta FosB (or engineered DNJunD), antagonists of the AP1 family of transcription factors, whic | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $6,639 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The extracellular matrix (ECM) has classically been viewed as a static scaffold that provides support to cells and tissues. However, recent studies have shown that ECM molecules form highly dynamic structures that cont | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF TOLEDO, THE | $149,815 | Grant | Trans-NIH Recovery Act Research Support: Award Description* Langerhans cells (LCs) are immature dendritic cell (DC) subsets that perform two key surveillancetasks (antigen sampling and detection of danger signals) at the environmental interface. Our objective is to define behavioral mechanisms b | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| MAINE MEDICAL CENTER | $310,120 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement is to accelerate our work on the function of several newly identified 3G??UTR polymorphisms that are important in post-transcriptional regulation of Igf1 mRNA, and to define how these SNPs may affect lineage allocation. The | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| CREIGHTON UNIVERSITY | $639,791 | Grant | Trans-NIH Recovery Act Research Support: Recently bone quality has been widely realized to be more predictive for risk of fragility fractures than bone mineral density (BMD). Our parent R01 human study (R01AR04054496) is to characterize defects in bone quality, independent of bone mass, that con | Health and Human Services, Department of / National Institutes of Health | 9/30/2010 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $60,256 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Mechanisms underlying mechanical properties of muscle-tendon units Atrophy, weakness, and injury of skeletal muscle are widely recognized as major contributors to age-related physical frailty, but the importance of cha | Health and Human Services, Department of / National Institutes of Health | 6/10/2009 |
| THE VANDERBILT UNIVERSITY | $219,365 | Grant | Trans-NIH Recovery Act Research Support: In this supplemental proposal for CA34590 we are investigating a number of ways to interrupt chemokine receptor facilitated metastasis by blocking chemokine receptor mediated cell migration. We are using time lapse intravital imaging of the tumor microenv | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| BAYLOR COLLEGE OF MEDICINE INC | $26,806 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement was to support 3 summer students who were interested in careers in research. This was the first experience for 2 of these individuals and 1 was continuing his honors thesis in the lab. Cancer is a major cause of morbidity a | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| WAYNE STATE UNIVERSITY (INC) | $276,140 | Grant | Trans-NIH Recovery Act Research Support: The samples obtained from the WUS will be genotyped by the NCI for approximately 550,000 SNPs. Approximately 500 cancer cases and 500 controls will be genotyped with frequency matched on study, age, sex and smoking. These SNPs will be analyzed in the NCIG | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $310,965 | Grant | Trans-NIH Recovery Act Research Support: Von Hippel-Lindau disease is a hereditary cancer syndrome characterized by an increased risk of central nervous system tumors (hemangioblastomas), kidney cancer, and adrenal gland tumors (pheochromocytomas). This disorder arises in individuals who harbor | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF ILLINOIS | $16,218 | Grant | Trans-NIH Recovery Act Research Support: The objective this administrative supplement is to fund two undergraduate student research assistants to work on cancer relevant basic science research. The individuals recruited for this project will be from a large pool of several hundred undergraduate | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF NEBRASKA | $149,600 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Human herpesvirus type 8 (HHV-8) or Kaposi's sarcoma associated herpesvirus (KSHV) is the etiologic agent associated with Kaposi's sarcoma (KS). Since the onset of the AIDS epidemic, KS has become the most frequently d | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| EASTERN VIRGINIA MEDICAL SCHOOL | $105,523 | Grant | Trans-NIH Recovery Act Research Support: The Human T-Cell Leukemia Virus type 1 causes Adult T-Cell Leukemia and HTLV-Associated Myelopathy/Tropical Spastic Paraparesis. It is believed that transformation of the infected T-cell by the viral protein Tax results in disease. The process by which Ta | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH | $216,600 | Grant | Trans-NIH Recovery Act Research Support: The modulation of 4-HNE and its glutathione conjugate levels in lung cancer cells through inhibition of its metabolism and disposition can optimize the cancer cell killing by activation of both Fas and p53-mediated apoptotic signaling. These studies will | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $57,509 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The overall goal of this project is to elucidate the mechanism of action of polyamine analogues in facilitating the uptake and function of antisense oligonucleotides (ODNs). The hypothesis is that the selectivity of po | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| GEORGETOWN UNIVERSITY (THE) | $96,935 | Grant | Trans-NIH Recovery Act Research Support: Funds from this research supplement are being used to support pre-doctoral student Marina Carla Cabrera. The primary aim of the project supported by the supplement is to determine if the mechanism responsible for maintenance of dysplasia in salivary tiss | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $376,079 | Grant | Trans-NIH Recovery Act Research Support: The objectives of this research project are to synthesize and develop novel targeted nanoglobular gadolinium(III) chelates as safe, effective and tumor-specific contrast agents for diagnostic cancer imaging with magnetic resonance imaging (MRI). The FDA a | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $149,896 | Grant | Trans-NIH Recovery Act Research Support: Thyroid cancer is the most common endocrine malignancy with an annual incidence of 21,000 in the U.S. 5- 10% of patients have advanced thyroid cancer that is unresponsive to standard therapy, and 1,500 patients die each year from this disease. There are C | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $349,606 | Grant | Trans-NIH Recovery Act Research Support: Project Summary Abstract Prostate cancer (PCA) is the most frequently diagnosed invasive malignancy in the United States men and is the second leading cause of cancer-related deaths after lung (1). Chemoprevention of PCA has been suggested as a novel and | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $122,881 | Grant | Trans-NIH Recovery Act Research Support: Plan and Timeline For The Research And Career Development Experiences Proposed for Dr. Wright: Dr. Wright will commit twelve calendar months of her total effort for a period of two years to the project outlined below. This project was designed with sever | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| KAISER FOUNDATION HOSPITALS | $945,372 | Grant | Trans-NIH Recovery Act Research Support: The Pathways Study (CA105274) aims to examine the effect on recurrence and survival of 1) lifestyle factors such as diet, physical activity, quality of life, and use of alternative therapies and 2) molecular factors such as genetic polymorphisms involved | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| NEW YORK UNIVERSITY (INC) | $142,400 | Grant | Trans-NIH Recovery Act Research Support: This award is issued in response to Notice NOT-OD-09-056, Recovery Act Administrative Supplements to the parent grant (R01CA106296-05) entitled, G?Chemopreventive Effect of NSAIDs against Prostate Cancer. During this funding period of the parent grant, we | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF IOWA, THE | $143,570 | Grant | Trans-NIH Recovery Act Research Support: This study will evaluate 5-year outcomes in patients with head and neck cancer (HNC) using the Outcomes Assessment Study (OAS), a project initiated in 1995 at the University of Iowa to collect health related quality of life (HRQOL) data in this understudi | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $47,282 | Grant | Trans-NIH Recovery Act Research Support: Childhood cancer survivors represent a large and growing group of survivors who are at increased risk for developing subsequent cancers. Therefore, it is of critical importance that all preventable risk factors be minimized among this population. We have | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF ROCHESTER | $8,932 | Grant | Trans-NIH Recovery Act Research Support: Heat shock proteins and non-classical MHC class Ib are postulated to be important modulators of anti-tumor immune responses.The goal of the project is to learn, using the frog Xenopus as a non-mammalian comparative model, how these proteins can protect us | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| BAYLOR COLLEGE OF MEDICINE | $459,538 | Grant | Trans-NIH Recovery Act Research Support: The current project addresses a key question in osteosarcoma research that has not been addressed before and attempts to develop a new mouse model for aneuploid osteosarcoma. Unstable chromosome number known as aneuploidy is a hallmark of pediatric osteos | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| DUKE UNIVERSITY | $132,853 | Grant | Trans-NIH Recovery Act Research Support: No large-scale study within the United States has examined any aspect of the epidemiology of intracranial meningiomas, a lesion which accounts for up to 25% of all primary intracranial neoplasms. We propose to conduct a population-based case/control study | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BAYLOR COLLEGE OF MEDICINE | $66,005 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this grant is to provide summer research experience for a high school teacher under ARRA mechanism. Earlier, we have reported that mitotic regulation and apoptosis are mechanistically linked. Rad21, an integral component of cohesin, is cle | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $243,763 | Grant | Trans-NIH Recovery Act Research Support: Differences in the pattern of gene expression between normal brain and its tumors of glial origin can provide information useful for malignant glioma diagnosis and therapy. These tumors cannot be diagnosed until they become visible on MRI scans and cannot | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $546,469 | Grant | Trans-NIH Recovery Act Research Support: Multiple and often interrelated behaviors increase cancer risk, including tobacco use, physical inactivity, and dietary patterns. Cancer risk-related behaviors are disproportionately concentrated in lower socioeconomic status groups and among some ethnic | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| PALO ALTO RESEARCH CENTER INCORPORATED | $667,803 | Grant | Trans-NIH Recovery Act Research Support: The medical value of detecting circulating tumor cells (CTCs) in peripheral blood is now established, and a specific approach has FDA approval for managing metastatic patients. While the value is clear, it is also limited in application. For example, the | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $243,158 | Grant | Trans-NIH Recovery Act Research Support: The efficacy of treatment for non-small cell lung cancer (NSCLC) has improved only marginally over the past few decades. Chemoradiotherapy continues to have a narrow therapeutic index, and response rates are unpredictable, even after controlling for the k | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $204,869 | Grant | Trans-NIH Recovery Act Research Support: The University of Alabama at Birmingham (UAB) is Alabama's largest employer, with more than 18,000 faculty and staff at the university and in the health system, and is responsible for 52,900 full-time equivalent jobs within the university and community | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| KAISER FOUNDATION HOSPITALS | $343,694 | Grant | Trans-NIH Recovery Act Research Support: The parent project on which this supplement is based, the Medical Care Burden of Cancer: System and Data Issues [1 R01 CA114204], is addressing an existing information gap by examining and comparing the cost of care for cancer treatment among the elderly | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF TOLEDO, THE | $117,533 | Grant | Trans-NIH Recovery Act Research Support: The award is a supplement to an active project funded by NIH grant 5R01CA115495 entitled, G?Mechanisms of Ras-Induced Non-Apoptotic Cell Death in GlioblastomaG?. The overall goal of the project is to identify new molecular targets that can be exploited to | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $124,612 | Grant | Trans-NIH Recovery Act Research Support: CML (chronic myeloid leukemia) is unique in that the BCR/ABL oncogene drives disease onset and progression. Therapies inhibiting the BCR/ABL kinase, such as imatinib mesylate, have dramatically altered the treatment of chronic phase disease, but are less | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $99,995 | Grant | Trans-NIH Recovery Act Research Support: Funding is sought to purchase an inverted epifluorescent microscope equipped with environmental chamber and video capabilities to conduct in vitro tumor microenvironment studies. | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF UTAH, THE | $1,063,969 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application is submitted in response to Notice Number NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. Despite notable achievements in its treatment over t | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $655,909 | Grant | Trans-NIH Recovery Act Research Support: This proposal is being submitted in response to Notice Number (NOT-OD-09-058) and Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. Virtual colonoscopy (VC), also known as computed tomographic colon | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $92,000 | Grant | Trans-NIH Recovery Act Research Support: The project was awarded to support the acquisition of instruments required to perform the pharmacogenetic work proposed in the parent grant. We do expect to have atleast 2 publications in year 2010-2011 | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $1,969,722 | Grant | Trans-NIH Recovery Act Research Support: Chemotherapy and immunotherapy using monoclonal antibodies have been relatively ineffective for the treatment of brain tumors, in part because of the blood-brain barrier (BBB). Enhanced dose intensity may be achieved by using osmotic BBB disruption (BBBD) | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $347,000 | Grant | Trans-NIH Recovery Act Research Support: This is a Competitive Revision of R01DA017792-10, ?Anxiolytic Effects and Abuse of BZ Receptor Ligands?. The overall goal of the parent grant is to investigate the extent to which GABAA (a class of receptors that respond to the neurotransmitter gamma-amin | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $35,878 | Grant | Trans-NIH Recovery Act Research Support: Learned associations between stimuli and natural rewards are enhanced when discrepancies between anticipated and received reinforcement are encountered (e.g., prediction errors). For instance, during associative conditioning, operant behaviors and mesolim | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| WASHINGTON UNIVERSITY, THE | $155,823 | Grant | Trans-NIH Recovery Act Research Support: Studies performed under this grant have provided a foundation for understanding how drugs and other substances are distributed in the inner ear following local or systemic applications. Central to this work has been the development of computer programs th | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF ROCHESTER | $163,094 | Grant | Trans-NIH Recovery Act Research Support: The supplement will support the additional of a new professional staff person, a computer programmer, to our project. This new position will focus on the development of advanced physiological data analysis software, specifically to handle the large quanti | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. | $170,594 | Grant | Trans-NIH Recovery Act Research Support: Stimulus processing in mammalian vestibular organs Funds are requested to accelerate the pace of our research into mechanisms underlying neuronal firing patterns in vestibular afferent neurons. | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $100,000 | Grant | Trans-NIH Recovery Act Research Support: Transduction of mechanical stimuli - like those of sound and head movements - is the fundamental role of the inner ear and its sensory hair cells. Hair cells transduce deflections of their hair bundles, the sensory organelle, with stunning sensitivity. Wh | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| FLORIDA STATE UNIVERSITY, THE | $33,670 | Grant | Trans-NIH Recovery Act Research Support: Ion channels are a component of multiprotein scaffolds regulated by molecular protein-protein interactions to control electrical excitability of neurons and provide proper subcellular adjacencies to downstream cell signaling machinery. The salary requests | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. | $210,608 | Grant | Trans-NIH Recovery Act Research Support: Middle-ear Mechanics in normal and pathological ears This proposal defines the acoustic and mechanical causes of hearing loss in several middle and inner-ear pathologies, specifically tympanic membrane perforation, and superior canal dehiscence, and inves | Health and Human Services, Department of / National Institutes of Health | 6/30/2009 |
| UNIVERSITY OF IOWA, THE | $357,725 | Grant | Trans-NIH Recovery Act Research Support: The application is targeted to hire a postdoc that would be unemployed starting July 1st 2009 and to expand the number of PIs by adding two new faculty to the portfolio of investigators to accomplish a new scientific objective. In addition, the revision w | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $213,846 | Grant | Trans-NIH Recovery Act Research Support: Glucocorticoids (prednisone, methlyprednisolone, dexamethasone) have been employed for decades for control of hearing loss. However, little is known of the cellular and molecular processes of the ear that are under their control. Knowledge of these steroi | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $261,840 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: The middle ear plays a vital role in the sense and sensitivity of hearing, yet there is currently a lack of knowledge about the mechanisms of high-frequency middle-ear sound transmission in mammals. The overall goal of this project is to unde | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF WASHINGTON | $41,000 | Grant | Trans-NIH Recovery Act Research Support: We have developed a new behavioral assay to determine lateral line function. The requested high-speed camera will allow us to analyze fast movements for kinematic analysis of zebrafish swimming and orientation behavior. The data presented in the sister | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $233,427 | Grant | Trans-NIH Recovery Act Research Support: An understanding of how taste stimuli are processed by the central nervous system (CMS)is important because the taste of food is a major determinant of ingestion. As such, it impacts the study of a variety of eating disorders including anorexia, bulimia a | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF IOWA, THE | $245,840 | Grant | Trans-NIH Recovery Act Research Support: Linguistic and psychological theory coupled with empirical studies on the heritability of individual differences in language development and language disorders support the hypothesis that the capacity for language development in humans is genetically infl | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $160,373 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to understand synaptic transmission at the vestibular type I hair cell/calyx synapse. Three classes of morphological afferents have been described in the amniote crista and utricle. Calyx units contact type I hair cells (HCI) | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF IOWA, THE | $130,731 | Grant | Trans-NIH Recovery Act Research Support: Effective systemic treatments for diseases of the central nervous system require therapeutic agents that are able to cross the blood-brain barrier (BBB). Significant efforts are devoted to design drug molecules with the correct permeability characteristic | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SOUTHERN ILLINOIS UNIVERSITY | $7,121 | Grant | Trans-NIH Recovery Act Research Support: Chronic tinnitus is a phantom auditory sensation experienced by up to 15% of the population. Between 2% and 10% of the tinnitus population experience a continuous high frequency ringing or hiss sufficiently loud to impact severely on their quality of life | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $158,877 | Grant | Trans-NIH Recovery Act Research Support: Gene manipulation in vivo using transgenic or targeted gene deletion can result in embryonic lethality, developmental defects or compensation by other gene products, all of which confound interpretation of normal gene function. Alternate strategies have b | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $278,515 | Grant | Trans-NIH Recovery Act Research Support: Ambiguity in language is everywhere, and communication fails when the listener does not resolve ambiguity in the way the speaker intends. Our research program aims to characterize the importance of cognitive control for ambiguity resolution in multiple do | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CLEMSON UNIVERSITY | $223,500 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of the proposed research is to understand the tissue interactions and molecular mechanism underlying induction, patterning and cell fate specification in the vertebrate middle ear. This study examines the tissue interactions and functio | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $158,400 | Grant | Trans-NIH Recovery Act Research Support: A UNIFIED NEUROANATOMICAL MODEL OF SPEECH PRODUCTION AND PERCEPTION: IMPLICATIONS Apraxia of speech (AOS) and conduction aphasia are commonly caused by left hemisphere stroke and often severely affect speech production. Although the clinical profile invol | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| NORTHWESTERN UNIVERSITY | $203,267 | Grant | Trans-NIH Recovery Act Research Support: This project will expand the scope of the parent project by examining valance-related coding of odor in the human brain as well as its modulation by factors such as learning and context. This study will demonstrate how hedonic context modulates fmri ense | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| FATHER FLANAGAN'S BOY'S HOME INC | $356,607 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the parent R01 grant application DC010202 is translational, namely, to improve the clinical diagnosis of auditory pathology in infants and children (Aims 1-3), the monitoring of the effects of ototoxic drugs on adult hearing (Aim 4), and th | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $820,936 | Grant | Trans-NIH Recovery Act Research Support: This is a competitive supplement in response to NOT-OD-09-058 (NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications). Diabetes is a metabolic disorder that currently affects over 180 million people worldwide. Common t | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $8,150 | Grant | Trans-NIH Recovery Act Research Support: This proposal is based on the perceived need for the design and development of new biomaterials that will be utilized in repair and regeneration of tooth enamel. The major objective of our proposed study is to elucidate the molecular mechanisms involved i | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF FLORIDA | $182,725 | Grant | Trans-NIH Recovery Act Research Support: Porphyromonas gingivalis is the major etiological agent of adult periodontitis. Although well established as a periodontal pathogen, it has more recently been recognized that P. gingivalis may have an important role in systemic disease, including cardiov | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $291,952 | Grant | Trans-NIH Recovery Act Research Support: There is an urgent need to develop new means for potentiating protective immune responses against pathogens that infect the oral, gastric and urogenital mucosae. The objective of this proposal is to evaluate the mucosal adjuvant activities of LT-IIa and L | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $65,962 | Grant | Trans-NIH Recovery Act Research Support: The objective of the administrative supplement is to utlize the new technology of LATE-PCR for rapid identification of Candida isolates to the species level in oral rinses collected from patients with OPC. | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $16,400 | Grant | Trans-NIH Recovery Act Research Support: This supplement supported the hiring of two undergraduate students for the summer. Both students contributed to the progress of the project by processing brain tissue of rats that had undergone multi-day peripheral injections of gut peptides or multi-day | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF UTAH, THE | $87,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Porphyria cutanea tarda (PCT), the most common form of porphyria in humans, is associated with excess liver iron stores, alcohol abuse, hepatitis C and medicinal estrogen use. PCT is due to a reduction in the specific | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $84,131 | Grant | Trans-NIH Recovery Act Research Support: To enhance and accelerate the Specific Aims of my funded proposal, I am seeking funds to collaborate with Dr. Margarida Barroso (Albany Medical College) who has a long standing interest in protein-protein interactions within the cell and who has specific | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $8,200 | Grant | Trans-NIH Recovery Act Research Support: This project aims to understand how proteins which associate with the NHES C-terminus between aa 590-685 regulate NHE3. The proteins identified which bind NHES in the domain and are involved in its regulation under basal conditions include CK2, CaM KII, N | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $16,400 | Grant | Trans-NIH Recovery Act Research Support: Since the original budget period this application, the PI has offered summer college students an opportunity to work on projects related to the renal physiological questions proposed in the grant proposal. This gives the students the opportunity to learn | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | $103,313 | Grant | Trans-NIH Recovery Act Research Support: Regulation of Sinusoidal Perfusion in Shock Altered hepatic vascular regulation is a common event following shock or sepsis. Recent work shows that this is related to increased constrictor response to endothelin that is associated with decreased eNOS ac | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF WASHINGTON | $97,595 | Grant | Trans-NIH Recovery Act Research Support: The contribution of non-homeostatic factors to the recent increase of obesity incidence in Westernized populations such as the U.S., has now come to be appreciated. Ready availability and affordability of palatable, high caloric density foods; activation | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $52,097 | Grant | Trans-NIH Recovery Act Research Support: This award is issued in response to Notice OD-09-060, Recovery Act Administrative Supplements Providing Summer Research Experiences for Students and Science Educators. Growth hormone (GH) exerts profound physiological effects on growth and metabolism, an | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $81,640 | Grant | Trans-NIH Recovery Act Research Support: The renal potassium channel ROMK is important for potassium secretion in distal renal tubles. Dysregulation of ROMK leads to abnormal blood potassium levels, which are potentially life-threatening. Studies on regulation of ROMK channels will help unders | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $499,987 | Grant | Trans-NIH Recovery Act Research Support: This funds from this competitive supplement are being used to pursue experiments in Aim 1 of the parent R01, entitled G?Molecular Events in Urinary Tract FormationG?, which was dropped due to insufficient funds. This proposal focuses on understanding how | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $86,676 | Grant | Trans-NIH Recovery Act Research Support: This project goals is to understand signaling complexes that form on the NHE3 C-terminus aa 475-589, the domain closest to the N-terminal transport domain. This part of the protein is necessary for regulated and basal trafficking of NHE3 to the plasma mem | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $9,599 | Grant | Trans-NIH Recovery Act Research Support: (B) Tissue specific deletion of netrin-1 during acute lung injury. We are presently generating a floxed netrin-1 mouse model (see letter Ozgene, these mice will be available to us in summer 2009). We will then cross these mice with cre-recombinase mice fo | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $75,706 | Grant | Trans-NIH Recovery Act Research Support: The aims of the supplement for the parent grant 5 R01 DK062267 titled Neuronal Excitability and Motility in Colitis are (1) to use calcium imaging to evaluate neuromuscular function in the ulcerated region of TNBS-inflamed colon, which is a region in whic | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| EMORY UNIVERSITY | $99,906 | Grant | Trans-NIH Recovery Act Research Support: Acute flares of inflammatory diseases of the intestine are characterized by the migration of neutrophils across the intestinal epithelium into the lumen to form 'crypt abscess'. Adenosine is generated during active intestinal inflammation by the conversio | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF CONNECTICUT | $142,366 | Grant | Trans-NIH Recovery Act Research Support: Primary hyperparathyroidism is a common human endocrinopathy, and cyclin D1 (PRAD1) oncogene overexpression contributes to the pathogenesis of up to 40% of parathyroid adenomas. The proposed studies are designed to address the mechanisms through which cyc | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $122,938 | Grant | Trans-NIH Recovery Act Research Support: The CRIC study participants are a diverse group of people with kidney disease, half of whom have diabetes. This ancillary study of pulse wave velocity was undertaken to determine to what degree this non traditionalrisk factor influences the risks of targe | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CINCINNATI | $155,626 | Grant | Trans-NIH Recovery Act Research Support: Metabolic syndrome (MetS), a constellation of risk factors associated with development of cardiovascular disease and Type 2 diabetes, has reached epidemic proportions in western industrialized nations. About 47 million Americans have MetS. Consequently, i | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $29,929 | Grant | Trans-NIH Recovery Act Research Support: We hypothesize that deletion of GABAergic funciton of accumbens shell neurons will lead to constant disinhibition of target areas including the lateral hypothalamus, resultingin hyperphagia on palatable food and development of obesity. | Health and Human Services, Department of / National Institutes of Health | 6/22/2009 |
| UNIVERSITY OF MIAMI | $100,000 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the award is to study the effects of a novel inhibitory enzyme in podocytes called serpin B13. This enzyme inhibits cytosolic cathepsin L (main topic in paternal grant) that leads to podocyte injury and kidney disease. The studies of this a | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,464,614 | Grant | Trans-NIH Recovery Act Research Support: This project has obtained follow up photography of the fundus of CRIC patients. Analyisis of the photographs has been completed. We will be performing the statistical analysis of the results. This will allow us to investigate the relationship between pro | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DUKE UNIVERSITY | $98,516 | Grant | Trans-NIH Recovery Act Research Support: Prevention of child and adult obesity is a national public health priority. Optimal interventions would target young children and their overweight parents to capitalize on the formation of healthy eating habits and increased physical activity in the child | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF OREGON | $416,204 | Grant | Trans-NIH Recovery Act Research Support: In this proposed revision to the parent grant 5R01DK75549-3, entitled Molecular basis of host-microbiota signaling in the zebrafish gut, we propose to expand our analysis of intestinal alkaline phosphatase (IAP) function to mice. Using a zebrafish model, | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF PITTSBURGH THE | $91,674 | Grant | Trans-NIH Recovery Act Research Support: Damage to the spinal cord at suprasacral levels blocks voluntary voiding and initially produces complete urinary retention. However within a few weeks to several months after injury reflex bladder activity emerges which promotes partial recovery of lower | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $47,100 | Grant | Trans-NIH Recovery Act Research Support: The 14 members of Eph kinases constitute the largest subfamily of receptor tyrosine kinases in mammalian system and bind membrane-anchored ligands called ephrins. The pivotal role of Eph/ephrin interactions in regulating development of nervous and cardiov | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $101,700 | Grant | Trans-NIH Recovery Act Research Support: To date, the molecular mechanisms responsible for the remarkable genetic heterogeneity found in ADPKD cysts remain unknown. Similar karyotypic alterations have been described consequently to genomic instability. Our overall hypothesis is that PC1 disregul | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $86,733 | Grant | Trans-NIH Recovery Act Research Support: The renin-angiotensin system (RAS) is the major regulator of body fluid and electrolyte homeostasis. It also contributes to development of variety of renal and cardiovascular diseases such as hypertension. (PRO)renin receptor is the newest component to be | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF PITTSBURGH THE | $439,048 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Notice Number (NOT-OD-09-058) and Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications, and asks for competitive revision of R01DK78755. The acyl-CoA dehydrogenases (ACDs) are | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $27,855 | Grant | Trans-NIH Recovery Act Research Support: Fat is a critical, highly preferred macronutrient and one of the major contributing factors to the current obesity epidemic. Although reducing the percentage of fat in the American diet is a high priority, this effort has been hindered by our poor underst | Health and Human Services, Department of / National Institutes of Health | 7/29/2009 |
| CEDARS-SINAI MEDICAL CENTER | $128,090 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): There continues to be an urgent need for organs among the Hispanic American population. The primary objective of our study is to increase the organ donation rate in the Hispanic American population in the County of Los | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $319,167 | Grant | Trans-NIH Recovery Act Research Support: This proposal will result in the creation of one new job, a postdoctoral researcher hired specifically for this competitive revision. Moreover, the studies proposed here will provide new approaches to the diagnosis and treatment of esophageal squamous ce | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| PALO ALTO MEDICAL FOUNDATION FOR HEALTH CARE, RESEARCH AND EDUCATION (INC) | $55,648 | Grant | Trans-NIH Recovery Act Research Support: This award is issued in response to Notice OD-09-060, Recovery Act Administrative Supplements Providing Summer Research Experiences for Students and Science Educators. This grant will be used to provide research experiences for two high school students. | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $38,181 | Grant | Trans-NIH Recovery Act Research Support: The goal of this research is to develop and clinically implement a new method of quickly and reversibly blocking the conduction of action potentials in peripheral nerve. In our currently funded project, we have demonstrated that high frequency alternating | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $104,898 | Grant | Trans-NIH Recovery Act Research Support: Multiple sclerosis (MS) is a chronic central nervous system disease that affects 2.5 million patients worldwide. Currently, there is no cure for MS, but a number of disease modifying drugs have been either approved by the FDA or undergoing clinical trials | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $112,693 | Grant | Trans-NIH Recovery Act Research Support: The proposed research focuses on the development of highly cancer-specific, ultra-sensitive nanoprobes for MR imaging of breast tumors. These nanoprobes have the potential to provide early detection of breast cancer for timely intervention of this dreadf | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $36,355 | Grant | Trans-NIH Recovery Act Research Support: Standard structural brain imaging protocols result in images that cannot resolve structures smaller than 1- 2mm in size. Achieving significantly higher resolution would be of fundamental clinical and neuroscientific value, as it would allow the in-vivo de | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| WASHINGTON UNIVERSITY, THE | $130,252 | Grant | Trans-NIH Recovery Act Research Support: Many physiological processes function efficiently within a well-controlled pH range and significant deviations from this range typically are indicative of pathologic conditions. Within cells, maintenance of a pH gradient in different organelles allows for | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF WASHINGTON | $200,857 | Grant | Trans-NIH Recovery Act Research Support: The parent 1R01EB007643-01A2 grant entitled Nonlinear Acoustics in Calibration/Metrology of High Intensity Focused Ultrasound was awarded over the period of 4 years; and the starting date was 09/15/2008. The principal aims of that grant are to combine non | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $36,832 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose is to develop synthetic methods and conduct imaging studies leading toward the use of nontoxic, semiconductor, nanoparticle, imaging probes (quantum dots, QDs) in the management of human coronary artery disease. The expected outcomes a | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $676,216 | Grant | Trans-NIH Recovery Act Research Support: Stable, high relaxivity MRI contrast agents. Contrast agents play an important role in clinical magnetic resonance imaging (MRI). About one third of scans employ a contrast agent and these agents are almost exclusively gadolinium (Gd) based T1 agents that | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| NEW YORK UNIVERSITY (INC) | $785,000 | Grant | Trans-NIH Recovery Act Research Support: This grant will investigate and map epigenetic changes induced in CD3+ T lymphocytes of humans exposed to carcinogenic nickel compounds from a nickel refinery in Jinchang, China. Workers in this nickel refinery have very high exposure to carcinogenic nic | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $24,534 | Grant | Trans-NIH Recovery Act Research Support: Title of the main project is ?Role of Fra-1 in acute lung injury and repair.? The ARRA funding is to provide support to a summer student training. Acute lung injury (ALI) or its most severe form acute respiratory distress syndrome (ARDS), caused by exposu | Health and Human Services, Department of / National Institutes of Health | 7/11/2009 |
| UNIVERSITY OF PITTSBURGH THE | $741,303 | Grant | Trans-NIH Recovery Act Research Support: Mechanisms for Arsenic-Induced Vascular Disease In response to NOT-OD-09-058: NIH Announces the Availability of Recovery Act for Competitive Revision Applications; this is an application for a competitive revision to expand scope of the aims for 5R01-ES0 | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF PACIFIC | $67,000 | Grant | Trans-NIH Recovery Act Research Support: Dioxins, generated both commercially and naturally, are chlorinated polycyclic aromatic hydrocarbons that are highly toxic environmental contaminants. These agents are known to be potent rodent carcinogens and suspected human carcinogens. The best known p | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| MOUNT DESERT ISLAND BIOLOGICAL LABORATORY (INC) | $416,183 | Grant | Trans-NIH Recovery Act Research Support: The Comparative Toxicogenomics Database (CTD) is a publicly available resource (http://ctd.mdibl.org) that provides manually curated chemical-gene/protein interactions as well as chemical- and gene-disease relationships from peer-reviewed literature. Thes | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| WRIGHT STATE UNIVERSITY | $221,238 | Grant | Trans-NIH Recovery Act Research Support: This work should significantly enhance our understanding of the etiology of several human diseases associated with the polymorphic hs 1,2 enhancer as well as potentially lead to therapeutic interventions for these diseases. | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $1,212,792 | Grant | Trans-NIH Recovery Act Research Support: This supplement (a) adds the collection and laboratory analysis of dust samples from the home to obtain historical measures of polybrominated diphenyl ethers (PBDEs) and other home environmental exposures that cover the perinatal period, (b) expands the c | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF ILLINOIS | $561,382 | Grant | Trans-NIH Recovery Act Research Support: Goals: The parent award addresses the epigenetic basis whereby developmental exposures to natural or environmental estrogens predispose to prostate carcinoma with aging. Our working hypothesis is that natural or environmental estrogenic exposures at envi | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $612,000 | Grant | Trans-NIH Recovery Act Research Support: This is a competitive supplemental application to parent grant ES-015849 in response to Notice Number (NOT-OD-09-058) entitled: ?NIH Announces the Availability of Recovery Act Funds for Competitive Revision?. Prenatal and early postnatal events such as ma | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF RHODE ISLAND | $118,711 | Grant | Trans-NIH Recovery Act Research Support: This award is issued in response to Notice OD-09-060, Recovery Act Administrative Supplements Providing Summer Research Experiences for Students and Science Educators. Abstract Hepatic biliary excretion is an essential process that exists to aid the in th | Health and Human Services, Department of / National Institutes of Health | 6/17/2009 |
| UNIVERSITY OF CALIFORNIA, MERCED | $7,782 | Grant | Trans-NIH Recovery Act Research Support: The supplemental funds of this award are to support the summer employment of a UC Merced undergraduate student. During summer 2009, Adam Mazzotti, a UC Merced Senior in the Earth Systems Science program, participated in research associated with my curren | Health and Human Services, Department of / National Institutes of Health | 6/15/2009 |
| UNIVERSITY OF CINCINNATI | $97,244 | Grant | Trans-NIH Recovery Act Research Support: Manganese (Mn) is an essential element, yet is neurotoxic in excess. Despite the fact that infants and young children may be at greater risk for Mn neurotoxicity than adults, very few studies have evaluated the effect of chronic Mn exposure on child devel | Health and Human Services, Department of / National Institutes of Health | 6/17/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $751,446 | Grant | Trans-NIH Recovery Act Research Support: This application expands the scope and the methodology of the parent grant 'Visual/Spatial Properties of Posterior Parietal Neurons' to include two additional research aims. Most of the current knowledge about neural mechanisms underlying eye-hand coordi | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $363,919 | Grant | Trans-NIH Recovery Act Research Support: The title of this project is, Oxidative damage and cone cell death in RP. The project is an administrative supplement to EY05951. Published studies from the parent grant have demonstrated that in retinitis pigmentosa (RP), after rod photoreceptors die, co | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $27,258 | Grant | Trans-NIH Recovery Act Research Support: Additional effort and a new hire are requested to increase data collection and data analysis of unique polarization and fluorescence imaging measures of the human retina. Three undergraduates will be hired, one for computer science work and the other two | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $180,722 | Grant | Trans-NIH Recovery Act Research Support: The function of lysosomes and lysosome-related organelles is critical to human health as confirmed by many human genetic disorders and pathogen-induced illnesses that disrupt these processes. Our ongoing genetic, biochemical and cell-biological experimen | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF IOWA, THE | $54,082 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this research program is to elucidate the molecular mechanisms of the function and regulation of rod and cone cGMP-phosphodiesterases (PDE6). PDE6s serve as key effector enzymes in the vertebrate visual transduction cascade. Transduc | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| THE VANDERBILT UNIVERSITY | $264,396 | Grant | Trans-NIH Recovery Act Research Support: In this supplement, we request funds to accelerate the research tempo by (1) upgrading selected equipment infrastructure and (2) hiring research staff trained in the tools and techniques employed in the laboratory. We propose to replace aging and perhaps | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $302,637 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplemental award is to increase the pace of research progress utilizing a new in vivo model; not only will the project move forward, but there is also an opportunity for job creation and preservation | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $37,936 | Grant | Trans-NIH Recovery Act Research Support: An administrative supplement for EY12978, entitled G?Population Coding in the RetinaG? was requested. The focus of the project is on understanding how the retinal output cells collectively encode visual scenes and is divided into two parts: determining th | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. | $1,350,351 | Grant | Trans-NIH Recovery Act Research Support: Ocular infection by human adenovirus (HAdV) species D genotypes D8, D19, D37, and D53 causes epidemic keratoconjunctivitis (EKC), manifest by acute pseudomembranous conjunctivitis, punctate and macro-epithelial erosions, and delayed onset stromal keratiti | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF ILLINOIS | $530,341 | Grant | Trans-NIH Recovery Act Research Support: The research being conducted with the Supplement Award is within the parent NIH project R01 EY016094 [G?Development of Nanoscale Neuromodulating Platforms (NNPs)G?]. The overall project is aimed at developing light-sensitive molecular structures that can | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $392,372 | Grant | Trans-NIH Recovery Act Research Support: In visual search tasks, observers (Os) look for a target in a visual scene containing distracting stimuli. Some medical screening tasks (e.g. breast cancer & cervical cancer) are difficult visual search tasks. A characteristic of these tasks is low target | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF WASHINGTON | $560,303 | Grant | Trans-NIH Recovery Act Research Support: Chemical and thermal pain in the cornea is primarily transduced by a calcium- and sodium-permeable ion channel called TRPV1 expressed in nociceptors with cell bodies in the trigeminal ganglia. When injury (including surgery) or illness cause inflammation | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $373,879 | Grant | Trans-NIH Recovery Act Research Support: What allows us to link particular visual stimuli with particular actions? We frequently and rapidly form different types of associations. Some associations can be as simple as learning that red means stop, while green means go. More complex associations c | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| SCOTT & WHITE MEMORIAL HOSPITL | $22,354 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this award is to provide occupation in scientific research for an undergraduate student during the summer, to foster the studentG??s interest to pursue a career in health-related sciences, and to facilitate accomplishment of the goals of my | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| SMITH-KETTLEWELL EYE RESEARCH INSTITUTE, THE | $16,656 | Grant | Trans-NIH Recovery Act Research Support: This project uses a novel neuro-imaging technique to examine the flow of disparity information from V1 to extrastriate areas in human cortex. It relies on complex analytical techniques to localize the likely sources that generate the scalp potentials re | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $238,978 | Grant | Trans-NIH Recovery Act Research Support: The focus of this research is to study the intracellular trafficking during visual system development in Drosophila. Our goal is to identify and characterize intracellular trafficking compartments and pathways that instruct synaptic specificity. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DUKE UNIVERSITY | $437,609 | Grant | Trans-NIH Recovery Act Research Support: Primary open angle glaucoma (POAG) is a leading cause of blindness. This disease disproportionately affects African Americans, who have a four- to five-fold higher risk of disease than age-matched Caucasians. In addition to its high prevalence, the risk o | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $157,000 | Grant | Trans-NIH Recovery Act Research Support: We propose to continue our studies of the biochemical and biophysical mechanisms used by G protein signaling modules to organize, integrate and transmit information. The diversity, number and ubiquity of G protein-coupled receptors (GPCRs) account for the | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NEBRASKA | $144,281 | Grant | Trans-NIH Recovery Act Research Support: The large (>330 kb) dsDNA, plaque-forming chlorella viruses have provided new and unexpected gene products for the past 20 years, including several medically relevant proteins. The objectives of this proposal are a step toward the long-term goal of under | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $236,690 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this proposal is to understand the cellular processes that regulate high-fidelity eukaryotic DNA replication. Low fidelity replication and error-prone post-replication DNA repair can result in chromosomal aneuploidy and mutation | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CHICAGO, THE | $275,299 | Grant | Trans-NIH Recovery Act Research Support: Regulated exocytosis in non-excitable cells has several characteristics in common with excitable tissues yet remains poorly investigated. The activated macrophage secretes a large array of small and macromolecular products including cytokines, chemokines, | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $162,072 | Grant | Trans-NIH Recovery Act Research Support: For the new specific aim that was added in response to ARRA, it is proposed to use methodologies developed in our ongoing work on synthetic diiron intermediates to obtain and characterize corresponding FeMn analogs, namely Fe(III)Mn(III)-peroxo, Fe(III)-O | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF TEXAS AT SAN ANTONIO | $22,600 | Grant | Trans-NIH Recovery Act Research Support: The focus of the proposed research is the structure, functino and catalytic mechanisms of three non-heme iron enzymes involved in oxidative or nitrosative stress protection in air-sensitive bacteria. All of the enzymes proposed for study reductively scav | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $325,079 | Grant | Trans-NIH Recovery Act Research Support: Genetic disorders can often provide key insights into normal physiological processes. In this project, we are studying the premature aging disorder Hutchinson-Gilford Progeria Syndrome (HGPS). Gaining an understanding of HGPS is important in its own right | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $48,356 | Grant | Trans-NIH Recovery Act Research Support: Despite many years of research and despite great advances in our understanding of operon-specific regulation, we still do not have a clear view of how bacteria sense general nutrient insufficiency and how they integrate the multiple nutritional signals th | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $135,543 | Grant | Trans-NIH Recovery Act Research Support: a. Scope of the overall project and contribution of the requested supplement. The overall, original project has four specific aims, which in brief are: 1. To analyze meiotic functions and interactions of the Mre11/Rad50 complex 2. To continue our unique i | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF UTAH, THE | $130,583 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The primary goal of this application is to understand how the RNA editing enzymes called Adenosine Deaminases that act on RNA (ADARs) function in the nervous system. Caenorhabditis elegans will be used for these studie | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| GEORGETOWN UNIVERSITY (THE) | $105,199 | Grant | Trans-NIH Recovery Act Research Support: Computer Simulations of Electron Transfer Proteins | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF FLORIDA | $172,874 | Grant | Trans-NIH Recovery Act Research Support: Higher organisms establish cellular organization by targeting proteins to specific membrane bounded compartments. Most targeting processes involve translocation into or across a membrane bilayer. This is achieved by address signals contained within each p | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $106,479 | Grant | Trans-NIH Recovery Act Research Support: This is a request for an administrative supplement to the parent grant GM47022: Solute Effects on Biopolymer Processes, currently in a no-cost extension. The goal of the proposed research is to complete the specific aims (1-3) of GM47022 (2004) by extendi | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $248,874 | Grant | Trans-NIH Recovery Act Research Support: The entry of Ca2+ ions into the cytosol from the extracellular fluid and from endoplasmic reticulum (ER) stores is used as a signaling mechanism by virtually all cell types to regulate functions as diverse as electrical excitability, secretion, proliferat | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $61,995 | Grant | Trans-NIH Recovery Act Research Support: This proposal aims to characterize the chemistry and biology associated with DNA-mediated charge transport (CT). Specifically, roles for DNA CT in how DNA is damaged and repaired under oxidative stress will be explored. Experiments are proposed to examine | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $97,680 | Grant | Trans-NIH Recovery Act Research Support: We will be determining the role of the RhoGTPases downstream from Eph receptor signaling in neural crest morphogenesis. As part of the original award we examined the cell autonomous migratory ability of neural crest cells at the vagal level and compared t | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $129,396 | Grant | Trans-NIH Recovery Act Research Support: The ribosome is responsible for protein synthesis and is essential in all cells. Its faithful translation of the genetic code and the proper regulation of its activity are necessary for normal cell growth and development. Ribosome assembly is a complex an | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $197,266 | Grant | Trans-NIH Recovery Act Research Support: The principal aim of the previous grant was to use a combination of biophysical and computational techniques to evaluate the key features in the folding/misfolding of the 17 KD beta protein interleukin-1beta (IL-1beta). We have established that the slow f | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $171,409 | Grant | Trans-NIH Recovery Act Research Support: The Research Plan describes approaches toward recombinant production of two subcomplexes of the Tetrahymena telomerase holoenzyme. Two expression systems are most likely to give high yield of the over-expressed subunit complexes of interest: the standard | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE | $130,480 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The long-term objective of this project is to understand the relationship between the molecular structure of the mitochondrial citrate transport protein (CTP) and its mechanism of transport. This transporter catalyzes | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $241,119 | Grant | Trans-NIH Recovery Act Research Support: During metazoan development, large numbers of unwanted cells are eliminated by apoptosis, as are abnormal or dangerous cells in the adult. Correctly regulated apoptosis is essential for normal development and homeostasis of the adult. Our goal is to under | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| UNIVERSITY OF CHICAGO, THE | $72,589 | Grant | Trans-NIH Recovery Act Research Support: Delineating folding mechanisms has tremendous implications for human health and biological function. Folding errors in vivo may be responsible for the loss of more than 30% of synthesized polypeptides, while misfolded conformers have been implicated in a | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA CRUZ | $569,530 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The scope of this research program is to expand on a small part of Aim 3 of the original R01, which had limited goals. Our current revision aims to discover over 100 lipoxygenase inhibitors, optimize their activity and | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $138,530 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of the parent grant is to understand the molecular basis of early vertebrate embryogenesius with focus on the Nodal signaling pathway. Supplemental ARRA funding is used to employ ChIP-Seq (Chromatin immunoprecipitation) technology and | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $204,219 | Grant | Trans-NIH Recovery Act Research Support: Cardiolipin (CL) is an essential phospholipid for normal mitochondrial energy metabolism so that physiological and pathological perturbations in its levels result in alterations in the structure, function and assembly of mitochondria. CL is an integral pa | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $407,700 | Grant | Trans-NIH Recovery Act Research Support: Human immunodeficiency virus type 1 (HIV-1) genetic variation is high among virus populations and is of importance clinically for both drug resistance and vaccine development. A high rate of HIV mutation along with a high turnover rate of infected cells d | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $103,248 | Grant | Trans-NIH Recovery Act Research Support: The long range goal of this project remains to understand that role the polyadenylation plays in post-transcriptional regulation in prokaryotes. Although long considered to be a feature unique to eukaryotes, over the past 10 years it has been shown that | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $41,926 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this competing continuation proposal is to understand the mechanisms of action of general anesthetics on synaptic transmission. Understanding the mechanisms of both the therapeutic and undesired effects of existing general anesthetic | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| NORTHWESTERN UNIVERSITY | $141,248 | Grant | Trans-NIH Recovery Act Research Support: Eukaryotic genomic DNA exists and functions in a highly compacted form, as a repeating array of nucleosomes called chromatin. Nucleosomes occlude much of the DNA that wraps them from interaction with other gene regulatory proteins and enzymes, yet nucleos | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| UNIVERSITY OF MARYLAND | $248,650 | Grant | Trans-NIH Recovery Act Research Support: This grant addresses research aimed at mapping changes in ribsome structure during the translation elongation cycle and as a consequence of mutants in ribosomal proteins and ribosomal RNAs. Also addresses research in how specific ribosomal protein and rR | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| SEATTLE CHILDREN'S HOSPITAL | $171,408 | Grant | Trans-NIH Recovery Act Research Support: Mitochondrial Effects on Sensitivity to Anesthetics -- Our laboratory exploits a very simple animal model, the nematode C. elegans, to investigate the molecular mechanism of volatile anesthetic action. The overwhelming majority of genes in | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WASHINGTON | $58,375 | Grant | Trans-NIH Recovery Act Research Support: In this supplement request we aim to develop very general methods for computationally designing novel proteins to bind with high affinity to any specified surface of any target protein (with known crystal structure). If successful, such designed prot | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $135,300 | Grant | Trans-NIH Recovery Act Research Support: Coordinate Regulation of Nuclear DGK-q and PLD. There are two consequences of this finding for the studies proposed in our funded proposal. First, studies in our awarded proposal were designed to localize DGK-q to the nucleus in order to examine the effec | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF ROCHESTER | $32,474 | Grant | Trans-NIH Recovery Act Research Support: The current award provides supplementary support to allow us to maintain a currently-employed senior post-doctoral fellow during the last year of the project, which is currently being supported by a no-cost extension based on a limited carryover from the | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF ROCHESTER | $192,673 | Grant | Trans-NIH Recovery Act Research Support: Funding from this administrative supplement will be used to hire a technician. This will alleviate the administrative/lab management responsibilities of individuals who are working on the question proposed in the supplement: How is the process of nonsense | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| UNIVERSITY OF WASHINGTON | $124,695 | Grant | Trans-NIH Recovery Act Research Support: This a request for supplemental funding for an existing NIH grant (61-1583). The funding will provide in addition to equipment and supply needs, salary support for the remainder of the one-year extension period. The supplemental funding will be directed | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $217,542 | Grant | Trans-NIH Recovery Act Research Support: Substrate specificity and inhibitor selectivity of PDE's - ARRA This project aims at structural and biochemical studies of near-full length PDE5 and its complexes with substrate and selective inhibitors. These studies will provide not only insight into th | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $354,033 | Grant | Trans-NIH Recovery Act Research Support: Before any cell divides to yield viable daughters, it must first separate its duplicated chromosomes and splitits cytoplasm between them. This fundamentally important event, cytokinesis, must occur at the correcttime, after chromosome segregation, and pla | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $209,241 | Grant | Trans-NIH Recovery Act Research Support: This is a request for an Recovery Act Administrative Supplement for NIH grant GM61616. The supplement will speed up progress and importantly provide continued employment for well trained scientists working in the area of the structure and function of memb | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $88,449 | Grant | Trans-NIH Recovery Act Research Support: The endomembrane system of all eukaryotic cells consists of a collection of membrane bound compartments. Movement of materials amongst these compartments is achieved by the regulated trafficking of cargo vesicles between compartments. In the process of di | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $78,772 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Breast cancer is responsible for the second overall cause of cancer-related deaths among women. Despite this profound health risk, Immunotherapy for breast cancer has not been adequately developed as an integral part o | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $255,001 | Grant | Trans-NIH Recovery Act Research Support: Mitochondria are dynamic, essential, double-membraned organelles that perform a myriad of tasks within cells. Unlike their bacterial ancestors, they are not discrete entities. Isolated mitochondria are transient and in communication via fusion to form bot | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $72,407 | Grant | Trans-NIH Recovery Act Research Support: Pathogenic bacteria must assemble and secrete virulence factors to interact with host tissues and cause disease. Gram-negative bacteria have an outer membrane in addition to a cytoplasmic membrane and must secrete virulence factors across both these barri | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $268,763 | Grant | Trans-NIH Recovery Act Research Support: The packaging of the eukaryotic genome together with histone proteins into chromatin has profound implications for all processes that occur on the DMA template, including replication, transcription and repair. Chromatin assembly and disassembly are essent | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TEXAS A & M RESEARCH FOUNDATION | $111,180 | Grant | Trans-NIH Recovery Act Research Support: Dendrimers are an understudied class of nanometer-scale, globular polymers that offer candidates for the next-generation of polymer therapeutics. Size, shape, and composition impact all aspects of these vehicles including overall efficacy, bioavailability | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $97,362 | Grant | Trans-NIH Recovery Act Research Support: The goal of this research is to understand the mechanism of biosynthesis of peptide siderophores in bacteria. Our paradigms are two peptide siderophores produced by the pathogen Vibrio anguillarum. One is anguibactin, an important component of a plasmid-m | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $97,556 | Grant | Trans-NIH Recovery Act Research Support: Dynamic Networks and Mechanisms of Allosteric Communication in Proteins ? ARRA. This award provides supplemental funding for equipment upgrades for R01 GM066009 (same title as above). The general goal of the project is to determine the degree to which t | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $342,468 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this proposal is to understand the role of the RNA polymerase II C-terminal repeat domain (CTD) in transcription regulation during cell growth and quiescence. Understanding this regulatory process will be important in understand | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $107,784 | Grant | Trans-NIH Recovery Act Research Support: This supplemental study is designed to accelerate the speed of analyzing one mouse knockout (KO) model, which has been generated by the parental grant (R01-GM066225). The main objective of this parent grant was to characterize one small genomic region th | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $177,917 | Grant | Trans-NIH Recovery Act Research Support: Gonorrhea is the second most common sexually transmitted infection in the United States but with the emergence of resistant strains, only one class of antibiotic, third-generation cephalosporins, is now recommended for its treatment. To address this, we | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $730,789 | Grant | Trans-NIH Recovery Act Research Support: PREDICTIVE QSAR MODELING - ARRA This ARRA grant is a competitive supplement to my current NI-funded grant titled ?Predictive QSAR Modeling? To comment on uniqueness of the Supplement, there are two major computational approaches to drug design: ligand bas | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $141,355 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Efficient methods for the incorporation of nitrogen functional groups into organic molecules are critical for the discovery, development and production of pharmaceuticals and related biologically active molecules. This | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $232,417 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this project is to thoroughly elucidate the molecular mechanisms underlying auxin-mediated control of plant growth and development. Such knowledge will facilitate the manipulation of plant growth and development for the purposes of i | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE, INC. | $235,561 | Grant | Trans-NIH Recovery Act Research Support: An administrative supplement was awarded on 30 September 2009 for our R01 research grant entitled, Structures of Peptide Synthetases and Related Enzymes. Our research focus is on a family of enzymes called Non-Ribosomal Peptide Synthetases (NRPSs). These | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $14,353 | Grant | Trans-NIH Recovery Act Research Support: This grant is directed toward understanding signal transduction by phytochromes, a conserved family of photosensory proteins that photochemically convert between red and near infrared absorbing states upon isomerization of the linear tetrapyrrole chromoph | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| EMORY UNIVERSITY | $73,486 | Grant | Trans-NIH Recovery Act Research Support: The award title is Cosmc - A Novel Molecular Chaperone Regulating O-Glycans.? This supplemental funding has helped to promote our work on a unique protein Cosmc, which is involved in several human disorders. The funds here helped us retain and fund the wo | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $248,298 | Grant | Trans-NIH Recovery Act Research Support: Cell migration and morphogenesis are required for the development, growth, and survival of all metazoans, and these processes also play essential roles in pathophysiological scenarios, for example in cancer cell metastasis, wound healing, ischemia, and my | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WASHINGTON UNIVERSITY, THE | $155,729 | Grant | Trans-NIH Recovery Act Research Support: The long-term objectives of this application are to understand how hormones transduce signals to cells. The general strategy is to focus on a superfamily of seven transmembrane-spanning receptors that bind hormones and mediate signals via G proteins. The | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF TEXAS AT ARLINGTON | $83,286 | Grant | Trans-NIH Recovery Act Research Support: This supplement accelerates the pace of of our research by hiring a senior post doc whose support was scheduled to end for an additional year and by supporting a student during summer. Heteromorphic sex chromosomes determine males and females in many spec | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $87,133 | Grant | Trans-NIH Recovery Act Research Support: Mutations are the cause of many human genetic diseases and the main source of genetic variation in natural populations. Thus, elucidating the mechanisms of mutagenesis is of great significance. The fact that, in mammals, the number of germline cell divisi | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $94,712 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Gap junctions (GJ) are defined as clusters of closely packed membrane channels containing the connexin protein, connecting two adjoining cells. The channel is composed of two hexamers from each cell and contains oligom | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $325,148 | Grant | Trans-NIH Recovery Act Research Support: A fundamental problem in neurobiology is understanding how the potential for complex behaviors are established. Drosophila melanogaster is an excellent model system to explore this question, given that a robust behavior, mating behavior, is genetically pr | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| LUDWIG INSTITUTE FOR CANCER RESEARCH | $165,600 | Grant | Trans-NIH Recovery Act Research Support: Centrioles perform two critical functions in eukaryotes: (1) they direct the accumulation of microtubule nucleating/anchoring material to form centrosomes that play a critical role during cell division, and (2) they serve as basal bodies that direct the f | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $44,415 | Grant | Trans-NIH Recovery Act Research Support: Heat shock proteins (Hsps) play dual roles in cellular biology; they are the first line of defense against cytotoxic stresses, and are tightly integrated into signaling and regulatory pathways under normal growth conditions. A subset of Hsps, including Hs | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF IDAHO | $150,199 | Grant | Trans-NIH Recovery Act Research Support: This proposal is aimed at understanding the mechanism of TFP-suppression by A-motility. This supplement is well within the scope of the original project because these data stem directly from our work on AglZ and MglA and they add an unexpected dimension t | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| RUSH UNIVERSITY MEDICAL CENTER | $156,297 | Grant | Trans-NIH Recovery Act Research Support: This supplement was requested to accelerate the pace of research of the original grant within its approved scope. Namely to perform simulations of calcium selectivity and binding in proteins and ion channels. Additional employment will be provided for on | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $243,176 | Grant | Trans-NIH Recovery Act Research Support: Potassium channels in humans are encoded by an extended super-family of 78 genes. Specific K+ channel modulation therefore offers an enormous potential for the development of new drugs. Two channels of particular interest are the voltage-gated Kv1.3 and t | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE VANDERBILT UNIVERSITY | $55,053 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement is to purchase a new HPLC system with the goal to enable us to more rapidly and effectively explore the parent grantG??s hypothesis of a biosynthetic cross-over of two inflammatory pathways in vivo. The two pathways to be in | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $121,968 | Grant | Trans-NIH Recovery Act Research Support: The duplication of a single cell involves a series of tightly controlled stages called the cell cycle. The faithful replication of genetic information is essential to cell division as disruption of DMA replication leads to genomic instability, a hallmark | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $341,714 | Grant | Trans-NIH Recovery Act Research Support: Background. The ability of short interfering RNAs (siRNAs) to recognize mRNA is widely appreciated. siRNAs are entering Phase 1 trials, but their ultimate potential to impact human health is unclear. The overall goal of the parent proposal GM 77253 was to | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NEBRASKA | $333,085 | Grant | Trans-NIH Recovery Act Research Support: The focus of the proposed supplemental studies is to examine the post-translation regulation of human glutamate cysteine ligase (hGCL). The enzyme is a heterodimer comprised of a catalytic (hGCLC) and a regulatory (hGCLM) subunit. Association of hGCLM wit | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF WASHINGTON | $357,345 | Grant | Trans-NIH Recovery Act Research Support: Funds to purchase a Versonics Ultrasound Engine, a unique instrument that would serve our needs and provide additional capabilities to accomplish our goals for this effort. Attached to this proposal is a fixed quote for the cost of the engine.Salary suppo | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $159,644 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of the proposed research is to understand, in detail, the role of spliceosomal snRNAs in catalysis of the splicing reaction. In the active spliceosome, U6 and U2 snRNAs form a base-paired complex that helps position the reactants of the | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| OKLAHOMA STATE UNIVERSITY | $133,669 | Grant | Trans-NIH Recovery Act Research Support: To Investigate Mechanisms of Catalysis, Substrate Inhibition, and Product Inhibition/Activation of Human SULTs. The proposed bypass ordered mechanism and related alternative mechanisms will be investigated using kinetic analysis, isotope exchange, sulfate | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $410,964 | Grant | Trans-NIH Recovery Act Research Support: This is an administrative supplement to hire staff with expertise in the area of cell signaling and cell biology to enable in-depth studies of vascular smooth muscle cell (VSMC) phenotype outlined in the parent R01 grant. The main focus of this proposal i | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $259,736 | Grant | Trans-NIH Recovery Act Research Support: Cellular transplantation has emerged as a therapeutic approach to restore lost systolic function to the diseased heart. To date, cellular engraftment approaches have utilized a variety of donor cell types (namely, fetal cardiomyocytes, embryonic stem cell | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $125,064 | Grant | Trans-NIH Recovery Act Research Support: Habitual sleep duration varies greatly in the general population. Inadequate sleep duration has negative consequences on health, including metabolic, neuroendocrine, and cognitive functions, as well as mood. Both, short and long sleep durations have been | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $156,976 | Grant | Trans-NIH Recovery Act Research Support: This proposal seeks to elucidate the molecular pathways responsible for diaphragm fiber atrophy and decreased diaphragm force generation in patients exposed to the combination of diaphragm inactivity and mechanical ventilation. | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF WASHINGTON | $987,731 | Grant | Trans-NIH Recovery Act Research Support: This R24 resource-related research grant is focused on generating proteomic resources that can be applied to research using nonhuman primates. Included in the parent grant is the development of a bioinformatics infrastructure for the storage, interpretati | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $442,470 | Grant | Trans-NIH Recovery Act Research Support: The ATP-binding cassette (ABC) transporters compose one of the largest and most important families of transmembrane proteins in the biological kingdom. Within the ABC family is a group of molecules that are referred to as A class transporters that share s | Health and Human Services, Department of / National Institutes of Health | 8/25/2009 |
| SEATTLE CHILDREN'S HOSPITAL | $302,137 | Grant | Trans-NIH Recovery Act Research Support: CODEHOP: Unique web-based technology for gene discovery -- In this supplement request, we propose to use the newly developed iCODEHOP web application to develop a Point-of-Care (POC) diagnostic tool for broad-based detection of known and emerging influe | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $400,047 | Grant | Trans-NIH Recovery Act Research Support: This supplemental application requests scientific computing and personnel resources for two (2) NIDDK sponsored research projects. This two year supplemental request is intended to support the Data Coordinating Centers for two (2) NIDDK sponsored U01s: th | Health and Human Services, Department of / National Institutes of Health | 9/27/2009 |
| UNIVERSITY OF CHICAGO, THE | $60,870 | Grant | Trans-NIH Recovery Act Research Support: We are requesting a Recovery Act Administrative Supplement in order to facilitate our research goals to (1) conduct apoptosis studies within the pre-clinical cell-based model we developed using lymphoblastoid cell lines (LCLs) to associate genetic variati | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MICHIGAN STATE UNIVERSITY | $174,303 | Grant | Trans-NIH Recovery Act Research Support: Protein purification is a vital and expensive step in biomedical research and in the development and manufacturing of therapeutic proteins. Unfortunately, affinity methods, which are at the heart of most protein purifications, often present a bottleneck i | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $97,705 | Grant | Trans-NIH Recovery Act Research Support: This award is to replace equipment in the PI's laboratory that is more than 15 years old and no longer functional. The equipment is a laser and photon detector that are used to obtain Raman spectra and is used by students and researchers in the Carey lab | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| THE CHILDREN'S HOSPITAL OF PHILADELPHIA | $271,423 | Grant | Trans-NIH Recovery Act Research Support: Numerous human disorders arise from microdeletions and microduplications of relatively large genomic regions. These rearrangements can result in copy number alterations (CNAs) of one or more genes. Conditions arising from microdeletions and microduplicati | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $352,152 | Grant | Trans-NIH Recovery Act Research Support: Antibiotics are the most direct and effective approach available against many infectious diseases, but their usefulness is being undermined by the emergence and spread of drug-resistant pathogens. A novel strategy for combining antibiotics relies on drug | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| EMORY UNIVERSITY | $273,352 | Grant | Trans-NIH Recovery Act Research Support: Award Title: The PINK1 Mitochondrial Signaling Pathway Grant Number: 3R01GM082828-02S1 Mitochondria are dynamic multi-functional organelles crucial for cell life and death, yet the signaling pathways and regulatory mechanisms that control mitochondrial f | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $164,290 | Grant | Trans-NIH Recovery Act Research Support: This supplement will enhance and accelerate the research described in the project R01 GM082843-01A2 by taking advantage of new technologies and sources of data. The goal of the parent project is to identify the molecular pathways responsible for the origi | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $252,415 | Grant | Trans-NIH Recovery Act Research Support: Chromosome translocations are frequently associated with many types of blood cancers and childhood sarcomas. Clinically, chromosome translocations are important because they offer the ability to precisely diagnose the type of cancers and to tailor treatme | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF WASHINGTON | $483,600 | Grant | Trans-NIH Recovery Act Research Support: In this supplementary research request we propose to expand the scope and accelerate the rate of progress on our project GM083926, entitled 'Regulation of Cellular Functions by Cyclic Nucleotide Phosphodiesterase 8'. The parent grant contains 3 specific | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $30,382 | Grant | Trans-NIH Recovery Act Research Support: Transition metal ions are critical to life as we know it. 30% of all proteins contain a metal ion cofactor and these proteins play essential roles in fundamental processes such as respiration, oxygen transport and storage, cell division and migration, and | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $43,031 | Grant | Trans-NIH Recovery Act Research Support: Ectodomain shedding, the proteolytic cleavage of an integral membrane protein to release the extracellular domain from the host cell, affects a variety of biologically important proteins including growth factor precursors, cytokine receptors, amyloid prec | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| EMORY UNIVERSITY | $60,000 | Grant | Trans-NIH Recovery Act Research Support: The cell's ability to sense the environment and to determine the direction and proximity of an extracellular stimulus, followed by correct movement, is fundamental not only for brain development but also for immunity, angiogenesis, wound healing, and embr | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $199,597 | Grant | Trans-NIH Recovery Act Research Support: RNA-based enzymes are crucial in many important biological processes including translation and RNA processing. While in some RNA-based enzymes the RNA moiety alone is capable of performing catalysis, many of them contain proteins that are required for the | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF FLORIDA | $349,634 | Grant | Trans-NIH Recovery Act Research Support: We have elucidated the identities and functions of several small molecule signals that control development and mating in the nematode Caenorhabditis elegans. This family of signaling molecules, called ascarosides, is based on the dideoxysugar ascarylose m | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $422,234 | Grant | Trans-NIH Recovery Act Research Support: One of the most interesting of biological phenomena is cellular decision making, whether in the context of metabolic choices made by single-celled organisms in their daily lives or in the developmental choices made by organisms after the egg is fertilized | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| GEORGIA TECH RESEARCH CORPORATION | $167,328 | Grant | Trans-NIH Recovery Act Research Support: The understanding of many biological processes critically depends on the ability to track the complex dynamics of proteins and their interactions with other biomolecules in the context of a living cell. To date, single molecule methods have been effective | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WASHINGTON | $191,380 | Grant | Trans-NIH Recovery Act Research Support: Mitochondrial dysfunction is a common feature of Parkinson's disease, but our knowledge of the underlying molecular mechanisms is rudimentary. Recently, a genetic pathway that influences mitochondrial integrity has emerged from studies of the PINK1 and p | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| DUKE UNIVERSITY | $204,998 | Grant | Trans-NIH Recovery Act Research Support: One of the most influential findings of the last 20 years in molecular evolutionary studies has been that recombination rate is frequently correlated with nucleotide sequence diversity within a species. In Drosophila species, this relationship has been at | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $259,984 | Grant | Trans-NIH Recovery Act Research Support: Stem cells continuously produce highly differentiated but short-lived cells, such as blood, skin, intestinal epithelium, and sperm cells throughout life. Asymmetric stem cell division, which produces one self-renewed stem cell and one differentiated cell, | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CORNELL UNIVERSITY, INC | $200,000 | Grant | Trans-NIH Recovery Act Research Support: The Recovery Act Administrative Supplement funds will be used to complete the syntheses of several members of the guttiferone family of natural products and to evaluate their function. The proposed novel and concise synthetic architectural assembly will | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE | $62,651 | Grant | Trans-NIH Recovery Act Research Support: The ultimate goal of this research program is to understand how inteins catalyze and regulate the various steps in protein splicing and protein trans-splicing. Protein splicing is a posttranslational process in which an internal domain, termed an intein, | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $10,640 | Grant | Trans-NIH Recovery Act Research Support: Notch signaling is required universally for development in every tissue in all metazoans, and defects in the mechanism are associated with many human developmental diseases and cancer. A peculiar feature of the Notch pathway is the extent to which its act | Health and Human Services, Department of / National Institutes of Health | 7/10/2009 |
| THE VANDERBILT UNIVERSITY | $110,857 | Grant | Trans-NIH Recovery Act Research Support: Neural crest is a multipotent population of embryonic cells with the ability to contribute to a variety of adult derivatives including all the neurons and glia making up the enteric nervous system responsible for coordination of gut movements. Because neu | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| NORTHSHORE UNIVERSITY HEALTHSYSTEM RESEARCH INSTITUTE | $7,625 | Grant | Trans-NIH Recovery Act Research Support: Necrotizing enterocolitis is a common and devastating intestinal emergency that primarily affects premature infants, whose etiology, pathogenesis, and treatment strategies remain poorly understood. Findings in our lab and others has identified an importa | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE | $171,706 | Grant | Trans-NIH Recovery Act Research Support: Fragile X Syndrome presents with a clinical picture of mental retardation and behavioral abnormalities, including autism, resulting from the loss of function of an RNA-binding protein, FMRP. Although a small number of FMRP RNA targets have been validated, | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF ARIZONA | $78,885 | Grant | Trans-NIH Recovery Act Research Support: The objective of this administrative supplement request is to accelerate the pace of the parent grant, the goals of which are to create a chicken situ hybridization gene expression database and user interface and the populate it with expression informatio | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $134,380 | Grant | Trans-NIH Recovery Act Research Support: ARRA - Speech of Young Males with Fragile X Syndrome The purpose of this administrative supplement is to improve the efficiency and completeness of acoustic data collection as part of the parent grant, Speech of Young Males with Fragile X Syndrome. The p | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $71,157 | Grant | Trans-NIH Recovery Act Research Support: This research proposes to evaluate migration processes associated with race-ethnic redistribution -- both across and within large US metropolitan areas over the period 1975-2000 -- to detect tendencies toward greater minority dispersal. The last three dec | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $93,820 | Grant | Trans-NIH Recovery Act Research Support: Limb deformity is one of the leading congenital disorders and the genetic mechanism underlying a vast majority of these cases remain unknown. Limb is also a prominent organ in the studies of organ regeneration. Strong evidence suggests that limbs regenera | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $104,097 | Grant | Trans-NIH Recovery Act Research Support: Proper formation of neuronal network is essential for establishing a functional nervous system. The long term-goal of my research is to elucidate the mechanisms underlying the formation of neuronal connections as a step toward improving our ability to und | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| VETERANS MEDICAL RESEARCH FOUNDATION OF SAN DIEGO | $6,868 | Grant | Trans-NIH Recovery Act Research Support: This is a Diversity supplement to support an undergraduate student Yen Phan for a summer research project July 1 to August 31, 2009. A summer research project will introduce Yen Phan to biomedical research which will help her in her future career. | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $28,802 | Grant | Trans-NIH Recovery Act Research Support: We propose to hire one half-time coordinator who has recently completed a Bachelors of Science degree to promote increased enrollment. He/she will coordinate activities of additional study participants and assist with the analysis of the new biomarker of | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TEXAS BIOMEDICAL RESEARCH INSTITUTE | $145,554 | Grant | Trans-NIH Recovery Act Research Support: In response to the Notice of Availability of Recovery Act Funds for Administrative Supplements (NOT-OD-09-056), this proposal is an administrative supplement request related to our parent grant titled The Metabolic Syndrome in Mexican American Children (R | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WASHINGTON | $163,356 | Grant | Trans-NIH Recovery Act Research Support: This proposal seeks continuation of funding to collect data on adult participants first assessed as preschool children. The study adds earlier waves of data collection in which parents and children were assessed over a 15-year period: when children were o | Health and Human Services, Department of / National Institutes of Health | 9/27/2009 |
| NEW YORK UNIVERSITY | $121,865 | Grant | Trans-NIH Recovery Act Research Support: This supplement provides support for additional personnel to accelerate the pace of the research. This ongoing project examines the development of children's knowledge about and identification with social categories. The proposed studies move beyond pri | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF PITTSBURGH THE | $164,869 | Grant | Trans-NIH Recovery Act Research Support: In the proposed additional study, we intend to examine with objective measures inhibitory control and working memory in older children and adolescents adopted from the socially-emotionally depriving orphanages described above. These more specific neurocog | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $234,339 | Grant | Trans-NIH Recovery Act Research Support: This project expands the scope of the parent project by examining the role of G?pregnancy scaresG? in the processes leading to unintended childbearing. Our aim is to accelerate the science of the project by incorporating measures of pregnancy scares into | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND | $13,772 | Grant | Trans-NIH Recovery Act Research Support: Administrative supplemental funds were requested to support the summer employment of Anna Iosipiv, who was an upcoming high school senior, and Andrew Pridjian, a recent college graduate who entered medical school this fall. Both individuals are dedicated | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| UNIVERSITY OF WASHINGTON | $336,500 | Grant | Trans-NIH Recovery Act Research Support: Neonatal brain injury remains a significant problem in the United States, and globally. Perinatal asphyxia is estimated to contribute directly to 23% of neonatal deaths worldwide (920,000 neonates per year). We developed a nonhuman primate model of perina | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| LOMA LINDA UNIVERSITY | $70,675 | Grant | Trans-NIH Recovery Act Research Support: The cellular and biochemical changes that define ripening of the prepartum cervix occur well before birth. Recent findings indicate that the ripening process is associated with inflammation; immigration and activation of leukocytes coincide with the disco | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $116,884 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Relevance. This study will help policy makers as well as health and social service professionals understand the experiences of women who have not been successful in becoming work-ready and employed through the Temporar | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $151,875 | Grant | Trans-NIH Recovery Act Research Support: This application for supplemental funding to SpBase: A Sea Urchin Genome Datase, supports work that will extend and enhance the general aims of the parent project. Specifically, this proposal focuses on two aims: 1) To guide the accumulation of gene ex | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $488,951 | Grant | Trans-NIH Recovery Act Research Support: This program will develop new instrumentation and methods for cell-based high-throughput, high-content screening (HCS). The program addresses bottlenecks that severely limit HCS for (i) scale-up to drug discovery, (ii) for handling of small samples of hig | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CORNELL UNIVERSITY, INC | $419,259 | Grant | Trans-NIH Recovery Act Research Support: Technological innovations arising from the HapMap Project have dramatically increased the speed and accuracy of genotyping while greatly reducing cost. Public and private efforts are beginning to release an unprecedented volume of human genotype and DNA s | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC | $404,811 | Grant | Trans-NIH Recovery Act Research Support: Project funding has just been awarded/received; updates to follow next quarter. PROJECT SUMMARY: The goals of the parent grant are to continue developing our highly accurate sequencing by synthesis (SBS) system for low-cost, high-throughput sequencing. Th | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $745,195 | Grant | Trans-NIH Recovery Act Research Support: Title: Electronic Sequencing in Nanopores. This research will accelerate the progress made that addresses the first three closely related aims of HG003703 whose overall goal is to develop a device capable of inexpensive de novo sequencing. When fully deve | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $189,348 | Grant | Trans-NIH Recovery Act Research Support: The interactions between transcription factors (TFs) and their DNA binding sites are an integral part of the regulatory networks within cells. These interactions control critical steps in development and responses to environmental stresses, and in humans | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $244,339 | Grant | Trans-NIH Recovery Act Research Support: Our research is motivated by recent advances in highthroughput technologies, such as DNA microarrays, which make it possible to record the complete genomic signals that guide the progression of cellular processes. Future predictive power and discovery in | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| FOUNDATION FOR APPLIED MOLECULAR EVOLUTION, INC. | $261,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This project, targeted for the National Human Genome Research Institute, will apply nearly a dozen new technologies to improve the performance of DNA chip microarrays as they detect, quantitate, and characterize nuclei | Health and Human Services, Department of / National Institutes of Health | 9/19/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $253,194 | Grant | Trans-NIH Recovery Act Research Support: We propose to combine the best proven aspects of SBS with streamlined methods for DNA amplification and high-speed fluorescence imaging to develop and implement a platform for rapid and inexpensive genome resequencing and de novo sequencing. Our platform | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| FOUNDATION FOR APPLIED MOLECULAR EVOLUTION, INC. | $266,745 | Grant | Trans-NIH Recovery Act Research Support: Funds from this administrative supplement are being used in their largest portion to purchase an instrument (a Dr. Oligo) to support the manufacture of DNA molecules that incorporate and constitute reagens for genome sequencing. This instrument has been p | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MAYO CLINIC ROCHESTER | $5,587 | Grant | Trans-NIH Recovery Act Research Support: This grant provided a research experience for 1 summer students in health-related scientific research. | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $15,265 | Grant | Trans-NIH Recovery Act Research Support: Summer undergraduate research experience in studies of cardiac electrophysiology and arrhythmia using an in vitro model | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | $6,028 | Grant | Trans-NIH Recovery Act Research Support: Asthma is a chronic disease of the airways that afflicts 12-14 million individuals in the United States and accounts for large numbers of hospitalizations, emergency department visits, and missed school days. Alarming increases in asthma morbidity and mo | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| CLEMSON UNIVERSITY | $11,286 | Grant | Trans-NIH Recovery Act Research Support: Bioprosthetic heart valves (BHVs) derived from glutaraldehyde-crosslinked porcine aortic valves are used annually in thousands of heart valve replacement surgeries. These devices often fail clinically due degeneration and pathologic calcification. Underst | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| THE UNIVERSITY OF SOUTH DAKOTA | $16,646 | Grant | Trans-NIH Recovery Act Research Support: This award helps support an undergraduate student to do research in the PI's lab for two summers (2009 and 2010). This will provide a full-time summer job as well as hands-on research experience to 1 undergraduate student per summer. After the summer re | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $158,689 | Grant | Trans-NIH Recovery Act Research Support: This supplement will be used to hire a new member of our research group whose primary scientific goal will be to create recombinant aortic carboxypeptidase-like protein (ACLP) and specific cleavage products that are naturally produced in smooth muscle cel | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA BARBARA | $71,842 | Grant | Trans-NIH Recovery Act Research Support: This research examines the impact of chronic and acute perceptions of discrimination on psychological and physiological stress responses. Perceived discrimination is widely assumed to negatively affect both mental and physical health, but research directl | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $39,019 | Grant | Trans-NIH Recovery Act Research Support: This grant provided a summer research experience(s) for one science educator in health-related scientific research. | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $234,944 | Grant | Trans-NIH Recovery Act Research Support: The long range goal of the proposed experiments is to understand the function of myosin binding protein-C in the regulation of cardiac contraction. Mutations in cardiac myosin binding protein-C (cMyBPC) account for nearly half of all instances of inherite | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $151,079 | Grant | Trans-NIH Recovery Act Research Support: Over the past two decades, reactive oxygen species have been implicated as critical mediators of oxidative processes and disease mechanisms under physiological conditions. Therefore, it is of critical importance to have a direct technique capable of ident | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF PITTSBURGH THE | $207,825 | Grant | Trans-NIH Recovery Act Research Support: Although hypoxic pulmonary vasoconstriction (HPV) has been reported to affect all segments of the pulmonary circulation relatively little is known regarding vasoconstriction of small (<50um) intra-acinar arterioles. Our preliminary data suggest that hypo | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $289,157 | Grant | Trans-NIH Recovery Act Research Support: No cardiovascular disease has proved more recalcitrant than dilated cardiomyopathy and heart failure, as the best pharmacologic treatments slow, but do not reverse, the progression to end stage disease. Hope remains high for surgical interventions, and th | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $71,900 | Grant | Trans-NIH Recovery Act Research Support: The primary objective of this research is to clarify the extent to which daytime sleepiness influences the ability of adults with heart failure (HF) to take care of themselves. We believe that poor sleep impairs self care through its effects on cognition. | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $199,830 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the award is to accelerate progress on NIH grant HL085218. The expected outcome is an increase in research conducted under HL085218. It is expected that one additional submission to a peer reviewed journal will be made during the pe | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $221,717 | Grant | Trans-NIH Recovery Act Research Support: Parent Grant entitled: The Role of Hepatocyte Growth Factor Signaling in Alveolar Homeostasis. Administrative Supplement Project entitled: The Role of Hepatocyte Growth Factor Signaling in Reparative Response to Neonatal Hyperoxic Injury. | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| RUSH UNIVERSITY MEDICAL CENTER | $16,212 | Grant | Trans-NIH Recovery Act Research Support: This grant provided summer research experience for two college students in health-related scientific research. | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| NORTHWESTERN UNIVERSITY | $245,007 | Grant | Trans-NIH Recovery Act Research Support: The request for supplemental support is to further study the primary function of the mitochondrial ATP-binding cassette protein-1 (ABC1). With further study the role of thid novel protein In the transport of iron-sulfur cluster out of mitochondria and wou | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| THE VANDERBILT UNIVERSITY | $157,523 | Grant | Trans-NIH Recovery Act Research Support: The Bcl2 family of proteins is comprised of key regulators of cell death. The BH3-only members of this family act as sensors, relaying death signals to the core apoptotic machinery at the mitochondria. Pro-apoptotic BH3-only Bid is situated at the interf | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| BAYLOR COLLEGE OF MEDICINE | $214,286 | Grant | Trans-NIH Recovery Act Research Support: Control of blood flow in the brain by vascular endothelial cells Adenosine triphosphate (ATP) is a potent regulator of vascular tone in the cerebral circulation. This physiological agonist is r | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| THE VANDERBILT UNIVERSITY | $261,384 | Grant | Trans-NIH Recovery Act Research Support: A critical challenge facing emergency department (ED) physicians is how best to manage patients presenting with symptoms of heart failure. Currently, most patients being evaluated for heart failure are admitted to the hospital, yet not all of these patien | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $236,032 | Grant | Trans-NIH Recovery Act Research Support: Endothelial cell junctions in mechanotransduction The overall objective of this proposal is to define the molecular mechanisms of sensing and transduction of shear stress in endothelial cells. Based on our preliminary data, we hypothesize that PECAM-1 se | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $270,817 | Grant | Trans-NIH Recovery Act Research Support: The activities proposed in this Administrative Supplement are intended to accelerate the tempo of the scientific research described in the parent R01 grant , as it is to enable additional effort to be dedicated to objectives complementary to and emanating | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $237,862 | Grant | Trans-NIH Recovery Act Research Support: The supplement request is still within the scope of the approved project to further clarify how propyl hydroxyase domain (PHD) enzymes participate in the regulation of salt adaption of the kidneys. High salt diet inactivates PHD in the kidney, which incre | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF IOWA, THE | $229,644 | Grant | Trans-NIH Recovery Act Research Support: Role of syntaxin 6 regulated post-Golgi trafficking in angiogenesis refers to the establishment of new vessels from preexisting vasculature. Dysfunctions in angiogenesis can lead to several malignant, inflammatory, and ischemic disorders. New vessel forma | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE | $61,755 | Grant | Trans-NIH Recovery Act Research Support: The prevalent distribution of atherosclerotic lesions in the curvature and branches of arterial trees demonstrates the critical role of flow patterns in predisposing the arterial wall to atherosclerosis. Steady flows with a high magnitude of shear stress | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| DUKE UNIVERSITY | $203,942 | Grant | Trans-NIH Recovery Act Research Support: Success of modern epidemiological investigations into complex disease and, in particular, success of the Genes and Environment Initiative (GEI) will depend on development of methods that address these challenges and on their efficient, open source impleme | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| MAYO CLINIC | $255,711 | Grant | Trans-NIH Recovery Act Research Support: This Recovery Act Administrative Supplement request to R01 HL090595 is to provide employment for a postdoctoral fellow to accelerate the pace of progress on the PI's parent grant by working on a subset of projects already outlined in the grant. In this co | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| NATIONAL JEWISH HEALTH | $197,231 | Grant | Trans-NIH Recovery Act Research Support: The supplement is accomplishing two goals: 1) providing support and training for a recent highly promising graduate; and 2) accelerating the pace of science in the parent project and enhancing the scientific achievement within this project. The administ | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $254,993 | Grant | Trans-NIH Recovery Act Research Support: This proposal is in direct response to the American Recovery and Reinvestment Act and puts forward a research plan to be carried out by a new postdoctoral fellow that has been hired at funding receipt. The primary goal of the Administrative Supplement re | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $312,847 | Grant | Trans-NIH Recovery Act Research Support: Heart failure is a deadly epidemic with few therapeutic options. Ventricular restraint represents a promising non-transplant treatment currently in clinical trials. In this surgery, the heart is wrapped with passive material to prevent it from dilating an | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $216,300 | Grant | Trans-NIH Recovery Act Research Support: Caveolae, mitochondria, and cardiac protection. The series of experiments proposed in the ARRA supplement request will determine if localized expression caveolin to mitochondria can serve as a novel therapeutic target for protecting the heart from ischemi | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $301,204 | Grant | Trans-NIH Recovery Act Research Support: Schizophrenia is a chronic and debilitating mental illness with a prevalence of approximately 1%. A number of candidate genes are presently being investigated, although none has been definitively connected to the etiology of the disorder. Genetic linkag | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $535,645 | Grant | Trans-NIH Recovery Act Research Support: The ability to successfully form memories for arbitrary associations is essential for most acts of daily living. Numerous studies have shown that the hippocampus plays a critical role in associative memory. Recent work indicates that the perirhinal cortex | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF HAWAII SYSTEMS | $207,781 | Grant | Trans-NIH Recovery Act Research Support: Type 2 diabetes mellitus is currently viewed as one of the chronic disease with the most behavioral demands on the patient. Medication must be taken daily either orally or by injection, meals must be timed, types of food must be distinguished and determin | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $149,996 | Grant | Trans-NIH Recovery Act Research Support: The ultimate goal of this program of research is to maximize positive health outcomes for those with cancer by creating opportunities for individuals to fully express themselves regarding cancer symptoms and quality of life concerns. However, clinicians a | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $121,764 | Grant | Trans-NIH Recovery Act Research Support: Fever is an adaptive reaction, mediated by the CNS, in response to immune stimuli. Recent studies, including ones from previous cycles of this grant, have indicated that lipopolysaccharide (LPS) and pyrogenic cytokines activate production of prostaglandin | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| NORTHWESTERN UNIVERSITY | $128,100 | Grant | Trans-NIH Recovery Act Research Support: The goals of this supplement is to accelerate the pace of our aims by hiring a new technician and accelerate the pace of use of computers and interpretation of data by hiring a colleague with substantial simulation expertise. | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF KENTUCKY | $136,262 | Grant | Trans-NIH Recovery Act Research Support: There is overwhelming clinical evidence of the interactions between sleep and epilepsy, but the literature on seizure prediction has largely disregarded the effects of state of vigilance (SOV) on seizure generation. Existing seizure prediction algorithms | Health and Human Services, Department of / National Institutes of Health | 12/21/2009 |
| UNIVERSITY OF IOWA, THE | $582,540 | Grant | Trans-NIH Recovery Act Research Support: PREDICT-HD is an international 30-site observational study of persons at-risk for Huntington's disease (HD). PREDICT-HD capitalizes on two unique aspects of HD among neurodegenerative disorders the ability to know in advance who will develop the disease a | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE WASHINGTON UNIVERSITY | $35,559 | Grant | Trans-NIH Recovery Act Research Support: The primary means by which nerve cells communicate with each other is through the release of neurotransmitter at chemical synapses. The ability of the brain to process information depends on synaptic connections forming precisely and reliably between many | Health and Human Services, Department of / National Institutes of Health | 7/27/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $256,998 | Grant | Trans-NIH Recovery Act Research Support: The parent project proposed a genetic strategy to validate the role of the Fas/NO pathway in mutant SOD1 mice. This involves deletion of Fas or Fas ligand specifically in the central nervous system of in mutant SOD1 mice and subsequent evaluation of any i | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $81,713 | Grant | Trans-NIH Recovery Act Research Support: This Administrative Supplement for Summer Research Experiences for Students and Science Educators supports undergraduate students for the Summers of 2009, 2010, 2011, and 2012. The parent grant seeks to determine the role of Suppressor Of Cytokine Signal | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| UNIVERSITY OF WASHINGTON | $169,902 | Grant | Trans-NIH Recovery Act Research Support: The parent grant for this administrative supplement is conducting a clinical trial of intracranial pressure (ICP)-directed therapy for severe traumatic brain injury (TBI) vs. standard care without ICP monitoring in three centers in Bolivia. An observati | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $81,924 | Grant | Trans-NIH Recovery Act Research Support: Transcripts for two tetrahydrobiopterin (BH4) synthetic enzymes, GTP cyclohydrolase 1 (GCH1) and sepiapterin reductase, and a BH4 recycling enzyme quinoid dihydroypteridine reductase, are upregulated in dorsal root (DRG) neurons after peripheral nerve inj | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $28,010 | Grant | Trans-NIH Recovery Act Research Support: Intracerebral hemorrhage (ICH) is the deadliest stroke subtype. Warfarin, a widely used anticoagulant for prevention of thromboembolic stroke, increases both risk and severity of ICH. Thus, even relatively minor elevations in risk for ICH on warfarin can | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $34,655 | Grant | Trans-NIH Recovery Act Research Support: The molecular basis of nervous system development remains a central question in developmental biology. Identifying the mechanisms and different pathways that orchestrate pluripotency or multipotency of stem cells, as well as the molecular signaling that c | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE | $77,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Human memory is notoriously inaccurate. Whereas newly acquired memories tend to have high validity, over time subsequent experiences can change or degrade them, a phenomenon termed 'retroactive interference.' This is n | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $110,013 | Grant | Trans-NIH Recovery Act Research Support: A defining feature of REM sleep is paralysis of nearly all muscles. In REM sleep behavior disorder (RBD), the absence of REM atonia permits the appearance of dream enactment. This disorder is strongly associated with neurodegenerative diseases such as Par | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $256,499 | Grant | Trans-NIH Recovery Act Research Support: The goal of this supplemental proposal is to expand the experiments in R01 NS064025A1 entitled, 'Newborn Neurons in the Adult Hippocampal Network' by incorporating new techniques into the study of the survival of adult-generated granule cell (GC) neurons. | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $249,709 | Grant | Trans-NIH Recovery Act Research Support: The aims of the parent grant (R01RR020823-05) are to develop a modular, scalable, Open Source software package that is used to integrate top-down, bottom-up, middle-down, or other mass spectrometry data sets to automatically derive the PTM state of protei | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $110,050 | Grant | Trans-NIH Recovery Act Research Support: The current project is to collect data from young adults with normal eyes, to enhance analysis of data from the existing COMET/COSMICC cohort, a group of ethnically diverse, myopic young adults with 12 years of standardized, reliable measurements of refra | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| NEW ENGLAND COLLEGE OF OPTOMETRY, THE | $69,346 | Grant | Trans-NIH Recovery Act Research Support: To conduct preliminary comparisons of measurements of macular thickness, optic disc parameters, intraocular pressure (IOP) and central corneal thickness (CCT) between non-myopic young adults and COSMICC subjects. The study is designed to test 2 hypothese | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $183,868 | Grant | Trans-NIH Recovery Act Research Support: Common variable immunodeficiency (CVID) is a clinical diagnosis given to patients who suffer with am unexplained deficiency of serum immunoglobulins. The presenting complaint for most CVID patients is recurrent sinopulmonary infections. Among our clinic | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CHILDREN'S RESEARCH INSTITUTE | $13,347 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the requested supplement is to provide salary support for Vishwajith (Vish) Sridharan, a high school student. Vish would like to work in the laboratory of Dr. Steven Zeichner, the Contact Principal Investigator for the Parent Grant. Vish is | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $99,675 | Grant | Trans-NIH Recovery Act Research Support: Nuclear accidents or attacks inflict both radiation injury and trauma resulting in a combined injury. While, the extent of the combined injury varies depending on the location of the victim, history indicates that individuals that experience combined inju | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |