Recovery Tracker

How Much Stimulus Funding is Going to Your County?

Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page

Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.

Recipient Amount Type Description Federal Dept./Agency Date
UNIVERSITY OF WASHINGTON $499,513 Grant Trans-NIH Recovery Act Research Support: The requested spinning disk microscope will allow the core researchers at the University of Washington to advance research using live imaging technologies. The spinning disk microscope allows rapid sampling of fluorescent images in living specimens. Becau Health and Human Services, Department of / National Institutes of Health 5/06/2010
BLEVINS, LONNIE G $100,000 Contract : Develop medical database based on HL7 data objects, populate it with de-identified data obtained from MIT, develop general research query tools for posing research questions in database, develop web services for research and database support functions. Health and Human Services, Department of / National Institutes of Health 3/10/2009
NEW YORK MEDICAL COLLEGE $54,000 Grant Trans-NIH Recovery Act Research Support: The aim of the proposed project is to determine the role of the ID1 and E2A HLH transcription factors in angiogenesis by examining their effect on mesenchymal cell/pericyte growth, differentiation and production of growth factors. Mesenchymal progenitor ( Health and Human Services, Department of / National Institutes of Health 4/06/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $235,546 Grant Trans-NIH Recovery Act Research Support: We will purchase a three-laser Canto II research-only cell analyzer made by Becton, Dickinson and Company for the Stanford Shared FACS Facility. This system, which is capable of measuring two light scatter signals and up to eight fluorescence signals, wil Health and Human Services, Department of / National Institutes of Health 6/17/2010
THE VANDERBILT UNIVERSITY $96,800 Grant Trans-NIH Recovery Act Research Support: Endocrine islet cell production solves several distinct yet related problems: endocrine commitment, cell type specification, islet cell differentiation, and maturation. In this grant application, we propose to utilize Myt1 gene activity manipulation and c Health and Human Services, Department of / National Institutes of Health 6/14/2010
NORTHEAST OHIO MEDICAL UNIVERSITY $462,000 Grant Trans-NIH Recovery Act Research Support: Nuclear receptors are ligand-activated transcription factors that play important regulatory roles in human and mammalian physiology. We are interested in understanding the role of nuclear receptors in controlling lipid homeostasis. Our long-term goal is t Health and Human Services, Department of / National Institutes of Health 4/19/2010
UNIVERSITY OF WISCONSIN SYSTEM $361,817 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Age-related Macular Degeneration (AMD) is a condition of advanced degeneration of the macular portion of the retina that leads to progressive blindness in over 35% of the population over the age of 75, or about 8 milli Health and Human Services, Department of / National Institutes of Health 4/23/2010
NEW YORK UNIVERSITY (INC) $187,658 Grant Trans-NIH Recovery Act Research Support: Although little is known about malaria immunity, the accepted Malaria Immunity Paradigm (MIP) is that resistance requires years of closely spaced infections to develop, frequent infections to maintain, and can be compromised by parasite antigenic diversit Health and Human Services, Department of / National Institutes of Health 4/28/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $336,885 Grant Trans-NIH Recovery Act Research Support: We requested stimulus funds to increase the pace of enrollment, data analysis and dissemination of our study to improve the quality of communication between physicians and parents after newborn genetic screening. Many psychosocial complications after newb Health and Human Services, Department of / National Institutes of Health 8/01/2009
DENISON UNIVERSITY $317,852 Grant Trans-NIH Recovery Act Research Support: Ultraviolet (UV) radiation poses a serious threat to human health through its damaging effects on DNA. Such damage interferes with fundamental cellular processes, and can cause permanent changes to the DNA, leading to abnormal cell activity and clinical Health and Human Services, Department of / National Institutes of Health 4/30/2010
ROWAN UNIVERSITY $292,351 Grant Trans-NIH Recovery Act Research Support: Research to focus on the mechanism of action of several naturally derived alpha-helical HDP's selected for diverse host organisms and broad spectrum antimicrobial activity in order to develop new antimicrobials to combat antibiotic resistance. Health and Human Services, Department of / National Institutes of Health 7/01/2010
ATHENA GROUP INC., THE $72,774 Grant Trans-NIH Recovery Act Research Support: Teacher's iPod (TiP) Administrative Supplement for Summer Funding. This supplement provides summer research experience for high school students, undergraduate students, K-12 teachers, and faculty from non-research intensive institutions to build customiz Health and Human Services, Department of / National Institutes of Health 5/21/2010
UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. $144,000 Grant Trans-NIH Recovery Act Research Support: We request funding to recruit and hire a highly qualified senior post-doctoral research associate to provide the additional skills needed to permit maximal progress in achieving the goals of our current parent grant and a recent college graduate student t Health and Human Services, Department of / National Institutes of Health 4/17/2010
PRESIDENT & TRUSTEES OF BATES COLLEGE $419,048 Grant Trans-NIH Recovery Act Research Support: This research project seeks to determine the cellular and molecular mechanisms by which developmental exposures to lower-levels of arsenic increase body weight, fatty-liver disease and blood glucose levels in adult male mice and increase binuclear cell nu Health and Human Services, Department of / National Institutes of Health 5/10/2010
WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION $366,250 Grant Trans-NIH Recovery Act Research Support: The application is a pilot for a post-hospital home telemonitoring intervention to help people with lung cancer (CA) recognize changes in their condition and contact a clinician before emergent care is needed. WV lung CA illness and death rates exceed US Health and Human Services, Department of / National Institutes of Health 5/21/2010
WICAB, INC $139,183 Grant Trans-NIH Recovery Act Research Support: VISION SUBSTITUTION THROUGH THE TONGUE Health and Human Services, Department of / National Institutes of Health 9/01/2009
ICF INCORPORATED, L.L.C. $497,489 Contract : Professional Information Technology (IT) Management Support Services using the American Recovery and Reinvestment Act Funds under the exisiting non-competitively awareded, GSA MOBIS Group 84, Delivery Order No. HHSN276200700125U in accordance with the Sta Health and Human Services, Department of / National Institutes of Health 4/03/2010
CORPORATION OF MERCER UNIVERSITY, THE $381,100 Grant Trans-NIH Recovery Act Research Support: Heart disease is the leading cause of death in Georgia, and diabetics, the elderly, and African American women are most at risk. The cardiac stress test is the standard screening tool for assessing cardiac function, and electrocardiography (ECG), ultrasou Health and Human Services, Department of / National Institutes of Health 6/14/2010
FRED HUTCHINSON CANCER RESEARCH CENTER $2,000,000 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to enhance and accelerate the recruitment of men who have sex with men (MSM) into HIV vaccine clinical trials. This will be accomplished through three main lines of work: (1) the development and implementation of an innovative Health and Human Services, Department of / National Institutes of Health 5/17/2010
OHIO UNIVERSITY $426,122 Grant Trans-NIH Recovery Act Research Support: Loss of muscle strength (i.e. weakness) associated with aging is a huge problem as it limits physical independence and is a major factor in the development of disability. Many of the changes that accompany the loss of strength with aging coincide with tho Health and Human Services, Department of / National Institutes of Health 6/22/2010
RETROVIROX, INC. $356,280 Grant Trans-NIH Recovery Act Research Support: Small-molecule inhibitors of HIV-induced receptor downmodulation These ARRA funds will be utilized to screen a library of 50,000 small-molecules with a flow-cytometry based assay. The assays will be optimize to identify inhibitors of the HIV-induced down Health and Human Services, Department of / National Institutes of Health 4/05/2010
ICF Z-TECH, INC $6,011,433 Contract : The eRA/NBS Integration Project Health and Human Services, Department of / National Institutes of Health 5/26/2010
UNIVERSITY OF ARIZONA $14,996,000 Grant National Center for Research Resources, Recovery Act Construction Support: The University of Arizona College of Medicine recruited its first new faculty to the Phoenix Biomedical Campus in 2006, and currently has 22 faculty with research laboratories in the Arizona Biomedical Collaborative 1 (ABC 1).... Show more Health and Human Services, Department of / National Institutes of Health 3/31/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $228,015 Grant Trans-NIH Recovery Act Research Support: The 300kDa cation-independent mannose 6-phosphate receptor (CI-MPR) and the 46kDa cation-dependent MPR (CD-MPR) play a key role in lysosome biogenesis by delivering ~60 different newly synthesized acid hydrolases to the lysosome by binding to mannose 6-ph Health and Human Services, Department of / National Institutes of Health 4/15/2010
UNIVERSITY OF ROCHESTER $340,145 Grant Trans-NIH Recovery Act Research Support: Microscopic examination of benign and malignant tissues from humans and from animals is an essential component of many NIH-funded research projects. The whole slide imager will be used to make digital pictures of tissues that are now preserved on glass sl Health and Human Services, Department of / National Institutes of Health 5/13/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $499,576 Grant Trans-NIH Recovery Act Research Support: M. tuberculosis (Mtb) has caused a global health emergency. Yet little new chemotherapy against Mtb has emerged in decades. This application aims to target a pathway in the pathogen that is not essential for the pathogen to survive in vitro but is essenti Health and Human Services, Department of / National Institutes of Health 6/21/2010
DREXEL UNIVERSITY $653,804 Grant Trans-NIH Recovery Act Research Support: Localization of mRNAs with subsequent translation into new proteins provides a means to geographically regulate neuronal protein composition in distinct subcellular regions. In axons, this localized protein synthesis is needed for growth cone guidance an Health and Human Services, Department of / National Institutes of Health 7/15/2010
MOUNT SINAI SCHOOL OF MEDICINE $99,999 Grant Trans-NIH Recovery Act Research Support: The overall objectives of the proposed research are to investigate the biochemistry, molecular pathology, and potential therapy of acute intermittent porphyria (AIP), an autosomal dominant hepatic porphyria due to the half-normal activity of hydroxymethyl Health and Human Services, Department of / National Institutes of Health 5/31/2010
TARGESON LLC $31,500 Grant Trans-NIH Recovery Act Research Support: This supplement award was used to support salary for a full-time laboratory technician to work on a previously-awarded SBIR grant. This award enabled Targeson to hire one technican, who had been working part-time for the Company on an hourly basis, at ful Health and Human Services, Department of / National Institutes of Health 5/21/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $893,979 Grant Trans-NIH Recovery Act Research Support: Dopamine-glutamate plasticity in nigrostriatal injury: Exercise-enhanced recovery Principal Investigators: Michael Jakowec, PhD, and John Walsh, PhD. University of Southern California. The primary goal of this research proposal is to elucidate the molecul Health and Human Services, Department of / National Institutes of Health 6/15/2009
MEDICAL COLLEGE OF WISCONSIN, INC., THE $720,582 Grant Trans-NIH Recovery Act Research Support: Fatty acid ?-oxidation is the major energy-producing process in the liver, heart, and type 1 muscle fiber. It is carried out by a series of four reactions that successively cleave acetyl-CoA from fatty acyl-CoA. The rate of this process can be altered by Health and Human Services, Department of / National Institutes of Health 8/14/2009
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $38,390 Grant Trans-NIH Recovery Act Research Support: While GDNF signaling through the Ret receptor tyrosine kinase is essential for renal development in mice and in humans, the events that occur downstream of Ret to promote ureteric bud (UB) branching morpho- genesis remain largely obscure. This proposal co Health and Human Services, Department of / National Institutes of Health 5/21/2010
AKRON GENERAL MEDICAL CENTER $74,500 Grant Trans-NIH Recovery Act Research Support: computational & experimental analysis of tibial tuberosity transfers Health and Human Services, Department of / National Institutes of Health 6/03/2010
UNIVERSITY OF CINCINNATI $449,921 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Obesity and related disease such as diabetes remain major health threats in western societies. In order to better understand the molecular regulation of metabolic processes involved in body fat regulation, numerous gen Health and Human Services, Department of / National Institutes of Health 4/15/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $174,837 Grant Trans-NIH Recovery Act Research Support: University of North Carolina AIDS Clinical Trials Unit (ACTU)-ARRA University of North Carolina AIDS Clinical Trials Unit (UNC ACTU) - ARRA The purpose of this administrative supplement to the parent grant is to support the acceleration of the pace of t Health and Human Services, Department of / National Institutes of Health 6/01/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $48,194 Grant Trans-NIH Recovery Act Research Support: Susceptibility to and severity of many autoimmune diseases, including arthritis, are known to be closely linked with particular class II MHC alleles, but the mechanism of these associations remains unknown. We have found that class II alleles that form un Health and Human Services, Department of / National Institutes of Health 6/28/2010
WASHINGTON METROPOLITAN AREA TRANSIT AUTHORITY $67,594 Contract : These ARRA funds provided SmartBenefits on SmarTrip cards to NIH employees that they may use to ride MetroBus or MetroRail. The fare media may also be used on DASH, Ride On, Fairfax Connector, ART, CUE, Loudoun County Transit, Omniride, TheBus, DC Circula Health and Human Services, Department of / National Institutes of Health 2/19/2010
NATIONAL JEWISH HEALTH $111,281 Grant Trans-NIH Recovery Act Research Support: The incidence and mortality of allergic diseases, such as anaphylaxis, allergic rhinitis, atopic dermatitis and asthma, has tripled in the Western countries since 1980s, leading to a staggering economic burden. This supplement will further our understa Health and Human Services, Department of / National Institutes of Health 6/28/2010
ST. JUDE CHILDREN'S RESEARCH HOSPITAL $880,429 Grant Trans-NIH Recovery Act Research Support: Tuberculosis is a leading AIDS-associated, opportunistic infection and globally it has been estimated that twenty percent of AIDS patients die from tuberculosis. In this study we propose to explore and develop a novel class of nitroaromatic anti-tuberculo Health and Human Services, Department of / National Institutes of Health 6/18/2010
KINETIC MUSCLES, INC. $2,745,978 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This proposal demonstrates a novel healthcare delivery system that has the potential to significantly advance stroke rehabilitation monitoring and therapy. The broad, long-term objective is to provide accessible, affor Health and Human Services, Department of / National Institutes of Health 5/24/2010
OHIO STATE UNIVERSITY, THE $228,750 Grant Trans-NIH Recovery Act Research Support: Cortisol released from the adrenal cortex acts on liver, muscle, and adipose cells to regulate energy balance and to maintain blood glucose at constant levels. Precise control of blood glucose is critical because this sugar acts as the brain?s prime energ Health and Human Services, Department of / National Institutes of Health 4/12/2010
UNIVERSITY OF CALIFORNIA, DAVIS $87,554 Grant Trans-NIH Recovery Act Research Support: The overall purpose of this ARRA supplement is to develop a platform that overcomes the technical challenge of studying cellular autophagy and apoptosis. It is consistent with and within the scope of Aim2 of the original grant, designed to study ?Tyrosine Health and Human Services, Department of / National Institutes of Health 4/27/2010
CARNEGIE INSTITUTION OF WASHINGTON $10,000 Grant Trans-NIH Recovery Act Research Support: The project provides new insights into the secretion of sugars from human glandular cells. It deploys technologies developed in the parent grant, specifically nanosensors, to better understand sugar secretion, which is relevant for the transfer of sugars Health and Human Services, Department of / National Institutes of Health 5/20/2010
MICHIGAN STATE UNIVERSITY $45,492 Grant Trans-NIH Recovery Act Research Support: Engineered nanomaterials (ENM) have unique properties that can cause adverse health effects. Given their small size and potential for airborne dispersion, inhalation exposure to ENM might contribute to increased incidence or exacerbation of allergic airwa Health and Human Services, Department of / National Institutes of Health 5/16/2010
UNIVERSITY OF MARYLAND $113,100 Grant Trans-NIH Recovery Act Research Support: Monocytes and macrophages sense pathogens, tumors, tissue damage, and host-derived mediators in their environment and respond by differentiating into distinct functional phenotypes that mediate host innate immune responses. However, the process of macroph Health and Human Services, Department of / National Institutes of Health 6/28/2010
CHILDREN'S HOSPITAL MEDICAL CENTER $271,614 Grant Trans-NIH Recovery Act Research Support: This proposal seeks supplementary funding for investigations into the HLA region (MHC) of children with Juvenile Idiopathic Arthritis (JIA). The proposed work is within the scope of the initial U01 award (U01-AI067150 HLA/KIR Region Genetics in Pediatric Health and Human Services, Department of / National Institutes of Health 6/28/2010
ST. JUDE CHILDREN'S RESEARCH HOSPITAL $8,384 Grant Trans-NIH Recovery Act Research Support: The purpose of the requested supplement is to provide summer research experiences for a junior faculty member and 3 undergraduate students from Rhodes College. The participants from Rhodes College will assist research staff and graduate students with thr Health and Human Services, Department of / National Institutes of Health 7/15/2009
REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE $469,334 Grant Trans-NIH Recovery Act Research Support: The Analytical Chemistry Instrumentation Facility (ACIF) at the University of California Riverside is requesting funds for purchasing an LC-MS/MS system, which includes a Thermo Fisher Scientific TSQ Vantage triple-quadrupole mass spectrometer and an Agil Health and Human Services, Department of / National Institutes of Health 5/06/2010
MOUNT SINAI SCHOOL OF MEDICINE $788,664 Grant Trans-NIH Recovery Act Research Support: Both projects (NET positron emission tomography imaging in alcohol dependence and obesity as well s cannabinoid receptor type 1 imaging in alcohol dependence) within this program have progressed nicely and important methodological progress has been made i Health and Human Services, Department of / National Institutes of Health 6/22/2010
ALLENTOWN INC $91,836 Contract : Laboratory Equipment Health and Human Services, Department of / National Institutes of Health 4/08/2010
DATA SCIENCES INTERNATIONAL, INC. $56,540 Contract : RODENT TELEMETRY SYSTEM Health and Human Services, Department of / National Institutes of Health 4/01/2010
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE $499,800 Grant Trans-NIH Recovery Act Research Support: The transformative effect of Next Generation DNA sequencing (NGS) technologies on the biological and medical research community has resulted in an unprecedented potential for key discoveries at an accelerated pace not previously possible. The next generat Health and Human Services, Department of / National Institutes of Health 4/08/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $287,617 Grant Trans-NIH Recovery Act Research Support: The regulation of mRNA dynamics is key to the action of proteins involved in genetic diseases, viral infection, and response of cells to growth stimuli. As such, a deeper understanding has enormous potential for the basis of novel therapeutic development. Health and Human Services, Department of / National Institutes of Health 4/28/2010
TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER $1,159,869 Grant Trans-NIH Recovery Act Research Support: There is a need for community-based, culturally sensitive, cognitive-behavioral interventions to reduce sexual risk behavior among minority adolescent women for prevention of STI/HIV, substance use, unintended pregnancy and abuse. Studies of risk and prot Health and Human Services, Department of / National Institutes of Health 5/14/2010
TRUDEAU INSTITUTE, INC. $10,340 Grant Trans-NIH Recovery Act Research Support: The purpose of this supplement is to obtain a stipend for a college student summer research internship. The goal of this summer internship is to 1) generate data that is necessary for the future experiments of the parent R01 and 2) provide laboratory and Health and Human Services, Department of / National Institutes of Health 6/01/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $110,263 Grant Trans-NIH Recovery Act Research Support: University of North Carolina AIDS Clinical Trials Unit (ACTU)-ARRA. Since 2003, UNC-CH has collaborated with the North Carolina Department of Public Health in a statewide HIV testing initiative to detect AHI and has enrolled consenting patients in AHI pr Health and Human Services, Department of / National Institutes of Health 3/22/2010
UNIVERSITY OF WISCONSIN SYSTEM $148,500 Grant Trans-NIH Recovery Act Research Support: The proposed research is a longitudinal study from 30 to 60 months of age of approximately 200 children with a wide variety of initial vocabulary sizes resulting from a range of advantages or deficits in the types of phonological knowledge that support wo Health and Human Services, Department of / National Institutes of Health 6/21/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO ,THE $23,760 Grant Trans-NIH Recovery Act Research Support: The purpose of this administrative supplement application to support summer research work opportunities for five undergraduate nursing students from the University of Texas Health Sciecne Center at San Antonio School of Nursing is to engage students in nu Health and Human Services, Department of / National Institutes of Health 5/13/2010
WESLEYAN UNIVERSITY $497,532 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Circular clamps are evolutionarily conserved ring-shaped proteins that play a central role in a range of cellular processes, including DNA replication and repair, chromosome structure maintenance and cell cycle regulat Health and Human Services, Department of / National Institutes of Health 6/25/2010
UNIVERSITY OF MARYLAND $107,220 Grant Trans-NIH Recovery Act Research Support: Research objectives: The studies that Javier Robalino will conduct will fully integrate into the objectives of the parent grant. We propose to identify natural inducers of antiviral immunity in Drosophila. We will focus on testing the potential of virus-d Health and Human Services, Department of / National Institutes of Health 5/07/2010
UNIVERSITY OF MARYLAND $225,000 Grant Trans-NIH Recovery Act Research Support: Fundamental understanding of the molecular mechanism governing osteoblast differentiation is essential for developing novel therapeutics for osteoporosis and bone fracture. Transglutaminases TG2 and FXIIIa promote osteoblast differentiation in vitro, and Health and Human Services, Department of / National Institutes of Health 4/12/2010
VINDICO NANOBIOTECHNOLOGY $199,683 Grant Science, Recovery Act: Fully biodegradable polymersome-encapsulated Hemoglobin as a Novel Nanoparticle-b Health and Human Services, Department of / National Institutes of Health 4/07/2010
UNIVERSITY OF ILLINOIS $86,242 Grant Trans-NIH Recovery Act Research Support: The funded studies will share tissues from two ARRA Grand Opportunity awards between investigators to permit the analysis of additional endpoints. Specifically, male Wistar rats being perinatally exposed to BPA (late fetal and early neonatal life) in the Health and Human Services, Department of / National Institutes of Health 6/04/2010
UNIVERSITY OF UTAH, THE $64,017 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): As more health applications are developed to be consumer-oriented, health vocabularies that support such application are increasingly in demand. Research indicates both that there is a significant difference between co Health and Human Services, Department of / National Institutes of Health 4/19/2010
DUKE UNIVERSITY $292,500 Contract : Aim 1 - To continue the activities of the ovarian cancer association consortium (OCAC), a group that is dedicated to working together to identify and validate common low penetrance ovarian cancer susceptibility polymorphisms. OCAC will continue to meet ab Health and Human Services, Department of / National Institutes of Health 5/20/2010
YALE UNIVERSITY $500,000 Grant Trans-NIH Recovery Act Research Support: The challenge area (03-DK-102) is the development and validation of novel, noninvasive methods to detect and monitor disorders of relevance to NIDDK at early stages of disease before major organ damage and dysfunction has occurred. Novel diagnostic method Health and Human Services, Department of / National Institutes of Health 4/08/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $355,137 Grant Trans-NIH Recovery Act Research Support: The long-term goal of these experiments is to resolve the structural and functional organization of the neural networks responsible for controlling neuroendocrine CRH neurons in the paraventricular nucleus of the hypothalamus (PVH). The PVH is the key con Health and Human Services, Department of / National Institutes of Health 7/24/2009
OREGON STATE UNIVERSITY $45,759 Grant Trans-NIH Recovery Act Research Support: The escalating frequency of antibiotic resistant infections combined with the emergence of new infectious diseases underscores the critical need to develop novel antibiotics and better understand mechanisms of antibiotic resistance. This proposal addresse Health and Human Services, Department of / National Institutes of Health 4/19/2010
TEXAS TECH UNIVERSITY SYSTEM $107,632 Grant Trans-NIH Recovery Act Research Support: The project supported by the ARRA grant award analyzes the role of a loop in the three beta subunits of ATP synthase in coupling of catalysis and rotation. We investigate which properties of the loop, such as length, shape, and flexibility, are important Health and Human Services, Department of / National Institutes of Health 4/28/2010
UNIVERSITY OF ARKANSAS SYSTEM $455,706 Grant Trans-NIH Recovery Act Research Support: The Arkansas IDeA Network of Biomedical Research Excellence (INBRE) has as its primary goal the expansion of biomedical research capacity in Arkansas in the fields of Cellular Signaling, Growth and Differentiation. A critical component of the Arkansas INB Health and Human Services, Department of / National Institutes of Health 6/10/2010
PHYSICAL SCIENCES, INC. $116,751 Grant Trans-NIH Recovery Act Research Support: Physical Sciences Inc., and Massachusetts General Hospital propose to modify the prototype automated singlet oxygen monitor being developed and tested under the current Phase II SBIR program into a single, integrated device that can be used for PDT treatm Health and Human Services, Department of / National Institutes of Health 9/30/2009
MEDICAL COLLEGE OF WISCONSIN, INC., THE $186,891 Grant Trans-NIH Recovery Act Research Support: The purpose of this Administrative Supplement request is to accelerate the pace and achievement of the research being conducted under 1 R01 EB009557-01 'Computer Modeling of Surgical Outcomes for Nasal Airway Obstruction' and to explore an additional outc Health and Human Services, Department of / National Institutes of Health 7/30/2009
NATIONAL JEWISH HEALTH $247,185 Grant Trans-NIH Recovery Act Research Support: The 2009 H1N1 virus has mutated to escape some components of the innate immune response. However, how the virus escapes containment by the innate immune system is not known. We have two hypotheses that we plan to test in this proposal. One is that the 200 Health and Human Services, Department of / National Institutes of Health 6/07/2010
UNIVERSITY OF NEW MEXICO $301,000 Grant Trans-NIH Recovery Act Research Support: The study was designed to investigate whether S. mansoni infection activates the four transcription factors (BgRel, BgRelish, BgSTAT1, and BgSTAT2) in B. glabrata. Antibodies generated from our recently-produced recombinant proteins, and quantitative PCR Health and Human Services, Department of / National Institutes of Health 5/17/2010
UNIVERSITY OF NORTH DAKOTA $27,600 Grant Trans-NIH Recovery Act Research Support: Project Summary/Abstract Alzheimer's disease (AD) is a complex neurodegenerative disorder for which there is presently no effective therapy. While some genetic mutations are responsible for the familial AD forms, the causative factors for the non-familia Health and Human Services, Department of / National Institutes of Health 6/04/2010
BAYLOR COLLEGE OF MEDICINE $0 Grant Trans-NIH Recovery Act Research Support: Type 1 diabetes is currently managed with diet and insulin therapy. The protocols planned in this trial will target post-prandial hyperglycemia using glucagon suppressors pramlintide and exenatide. This trial will aim to determine a safe and effective dos Health and Human Services, Department of / National Institutes of Health 6/15/2010
MEHARRY MEDICAL COLLEGE $2,693,442 Grant Trans-NIH Recovery Act Research Support: The objective of this grant and the animal resources program at Meharry Medical College is to provide research investigators with a modern facility that serves their research needs in cardiovascular diseases, HIV AIDS research, women's health, brain and b Health and Human Services, Department of / National Institutes of Health 3/31/2010
NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC. $184,066 Grant Trans-NIH Recovery Act Research Support: This project addresses the need to protect active duty personnel and veterans from gonorrhoea. It is the next phase of an on-going program to develop a vaccine against gonococcal infection. This supplement is to add personnel to project tp dp the ELISAs Health and Human Services, Department of / National Institutes of Health 4/05/2010
WASHINGTON UNIVERSITY, THE $99,999 Grant Trans-NIH Recovery Act Research Support: Gene therapy approaches for diseases of the -globin gene (sickle cell anemia, -thalassemia) will be needed for definitive cures. In this grant, we will use Homology Directed Repair strategies to correct-globin mutations in induced pluripotent stem cells. Health and Human Services, Department of / National Institutes of Health 5/25/2010
UNIVERSITY OF WASHINGTON $129,541 Grant Trans-NIH Recovery Act Research Support: Urethritis, the most common male reproductive tract infection syndrome, resulted in over 200,000 physician office visits per year in 2001, the last year in which such data were collected. Nevertheless, the etiology of 20-50% of non-gonococcal urethritis Health and Human Services, Department of / National Institutes of Health 5/10/2010
CALIFORNIA INSTITUTE OF TECHNOLOGY $175,753 Grant Trans-NIH Recovery Act Research Support: AKTAxpress FPLC System for Protein Purification 1) Project Summary/Abstract Protein purification capabilities underlie structural biology, protein design, and all aspects of protein science. High-throughput automated protein purification can greatly enhan Health and Human Services, Department of / National Institutes of Health 5/06/2010
UNIVERSITY OF PITTSBURGH THE $21,271 Grant Trans-NIH Recovery Act Research Support: The parent grant, R01 AR051963 entitled Chondrogenesis in situ, focuses on safe, localized in vivo use of bioactive factors to improve the cartilage repair potential of adult human bone marrow cells. The goal of the administrative supplement grant R01AR05 Health and Human Services, Department of / National Institutes of Health 5/19/2010
MONTEFIORE MEDICAL CENTER $249,644 Grant Trans-NIH Recovery Act Research Support: Innovative biomedical research requires frequent access to the newest analytical techniques to advance knowledge of human diseases and to provide new treatments for these illnesses. The ability to measure many biomarkers efficiently and accurately is esse Health and Human Services, Department of / National Institutes of Health 4/22/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $559,707 Grant Trans-NIH Recovery Act Research Support: The Center for International Blood and Marrow Transplant Research (CIBMTR) provides a unique resource of data and statistical expertise to the scientific community for addressing important issues in hematopoietic cell transplantation (HCT). It is comprise Health and Human Services, Department of / National Institutes of Health 9/07/2009
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $3,335,363 Grant Trans-NIH Recovery Act Research Support: The 1000 genomes project is an initiative to obtain the completely genome sequence for 2000 individuals to create a reference set of common and less-common genetic variants across various structural genomic variant regions. Here we propose the use of arr Health and Human Services, Department of / National Institutes of Health 4/29/2010
RUSH UNIVERSITY MEDICAL CENTER $412,500 Grant Trans-NIH Recovery Act Research Support: Schistosomiasis is an important tropical parasitic human disease. Although an effective anti-schistosome drug is in use, it is estimated that 200 million people are infected, 20 million individuals suffer severe disease symptoms, and 280,000 people die an Health and Human Services, Department of / National Institutes of Health 5/29/2009
UNIVERSITY OF CALIFORNIA, DAVIS $181,066 Grant Trans-NIH Recovery Act Research Support: The supplemental grant supported additional personnel with expertise in the area of numerical methods and computation. We carried out software and hardware-based approaches to improving the computational efficiency of large-scale partial differential equa Health and Human Services, Department of / National Institutes of Health 3/23/2010
MOUNT SINAI SCHOOL OF MEDICINE $254,089 Grant Trans-NIH Recovery Act Research Support: This administrative supplement to existing NIH grant 5 R01 DK054830 has been solicited by the Program Director, Dr. Catherine McKeon. It requests funds to expand the existing research in two ways: a) by purchasing new equipment, and b) re-directing the e Health and Human Services, Department of / National Institutes of Health 4/06/2010
THE INSTITUTE FOR CANCER RESEARCH $10,665 Grant Trans-NIH Recovery Act Research Support: Title: Structure and Function of Integrase Abstract: The proposed summer project is related to Aim 3 of the parent grant, entitled ?Structure and Function of Integrase?. The goal of this Specific Aim is to prepare stable complexes containing integrase (I Health and Human Services, Department of / National Institutes of Health 5/24/2010
MAYO CLINIC $114,836 Grant Trans-NIH Recovery Act Research Support: The long term objective of our work is to better understand the pathogenesis of Graves' ophthalmopathy (GO) in order to aid in the the development of new approaches to treatment or prevenetion of this disease. The goal of the laboratory investigations in Health and Human Services, Department of / National Institutes of Health 4/29/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $418,732 Grant Trans-NIH Recovery Act Research Support: The purpose of this proposal is to acquire NIH funding for a Carl Zeiss LSM 710 laser scanning confocal microscope for the CNR Biological Imaging Facility, and specifically, will permit the research goals of eight (8) Major Users listed in this proposal t Health and Human Services, Department of / National Institutes of Health 5/06/2010
TRUSTEES OF INDIANA UNIVERSITY $496,921 Grant Trans-NIH Recovery Act Research Support: This is not an ARRA funded project. Please disregard this report. No future reporting will be done on this award number. Vincristine is among the most commonly used anticancer agents, however; little is known about its disposition and optimal therapeut Health and Human Services, Department of / National Institutes of Health 9/29/2009
POLYWELL COMPANY, INC. $1,887,652 Contract : BARCODING DLIEVERY SYSTEM, WORKSTATIONS ON WHEELS Health and Human Services, Department of / National Institutes of Health 9/30/2009
UNIVERSITY OF MARYLAND $2,830,485 Grant Trans-NIH Recovery Act Research Support: This application requests funds to purchase a 3T scanner system to establish a research-dedicated neuroimaging facility at the University of Maryland (UM) System. This is in response to the Recovery Act Limited Competition (S10) PAR-09-118. We propose to Health and Human Services, Department of / National Institutes of Health 5/20/2010
ILLINOIS STATE UNIVERSITY $346,538 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Mucosal IgA is an important first line of defense against pathogens and may even help prevent autoimmune disease. The effectiveness of systemic immunity declines with age, leaving the elderly susceptible to life- threa Health and Human Services, Department of / National Institutes of Health 4/05/2010
UNIVERSITY OF CALIFORNIA, DAVIS $500,000 Grant Trans-NIH Recovery Act Research Support: Defensins are key effector molecules of the innate immune system that both serve as endogenous antibiotics to protect mucosal surfaces and modulators of adaptive immune responses. Data from numerous investigations, including those supported by this grant Health and Human Services, Department of / National Institutes of Health 6/14/2010
DUKE UNIVERSITY $234,000 Grant Trans-NIH Recovery Act Research Support: Smooth muscle (SM) and striated muscle (SKM) are highly plastic, able to adapt their contractile properties in response to a variety of physiological settings such as exercise and pregnancy. Adaptations in these muscles involve coordinated changes in tran Health and Human Services, Department of / National Institutes of Health 5/13/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $7,459 Grant Trans-NIH Recovery Act Research Support: Heparan sulfate is a highly sulfated polysaccharide with very complicated saccharide structures. Heparan sulfate is present on the cell surface and in the extracellular matrix in a large quantity, and plays important roles in a wide range of physiological Health and Human Services, Department of / National Institutes of Health 5/17/2010
EMORY UNIVERSITY $250,582 Grant Trans-NIH Recovery Act Research Support: Project Title: CTL and HIV Polymorphisms in Heterosexual Transmission The major goal of this project is to determine whether certain persons have a genetic background that can make them less likely to be infected by HIV. Several human genes encode for fa Health and Human Services, Department of / National Institutes of Health 5/17/2010
THE CHILDREN'S HOSPITAL OF PHILADELPHIA $99,551 Grant Trans-NIH Recovery Act Research Support: Lysosomal storage diseases (LSDs) are a large group of inherited enzyme deficiencies that produce fatal degenerative syndromes in children, with most having severe brain disease manifest as mental retardation. Neurogenetic diseases have lesions throughout Health and Human Services, Department of / National Institutes of Health 5/28/2010
WILLIAM MARSH RICE UNIVERSITY $500,000 Grant Trans-NIH Recovery Act Research Support: Fluorescent microscopy has revolutionized modern biology. From calcium sensitive dyes that track the exquisite regulation of this second messenger to fluorescent fusion proteins that allow us to pinpoint the subcellular distribution of proteins, our abili Health and Human Services, Department of / National Institutes of Health 5/13/2010
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK $782,500 Grant Trans-NIH Recovery Act Research Support: Statistics on the health-related and economic costs of alcohol abuse were summarized in the application. We consider that the consequences of acute intoxication and of alcohol consumption by individuals with reduced acetaldehyde dehydrogenase 2 activity c Health and Human Services, Department of / National Institutes of Health 6/09/2009
THE INSTITUTE FOR CANCER RESEARCH $10,665 Grant Trans-NIH Recovery Act Research Support: Title: Low Activity Oligomers of Porphobilinogen Synthase as Antibiotic Targets Abstract: Porphobilinogen synthase (PBGS) catalyzes the essential formation of the fundamental biological monopyrrole, porphobilinogen in the pathway toward the biosynthesis Health and Human Services, Department of / National Institutes of Health 6/01/2010
DUKE UNIVERSITY $156,820 Grant Trans-NIH Recovery Act Research Support: The overall objective is to define the Ca2+-dependent signaling pathway in hypothalamic neurons that regulates appetite and body weight to provide novel insights to human obesity. AMPK, originally discovered to protect cells against stresses that deplete Health and Human Services, Department of / National Institutes of Health 5/04/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $14,567,188 Grant National Center for Research Resources, Recovery Act Construction Support: UNC Animal facilities construction for replacement of Francis Owen Blood Research Laboratory The purpose of this grant is to construct new animal housing for the FOBRL. The FOBRL conducts research in hemostasis and thrombosis... Show more Health and Human Services, Department of / National Institutes of Health 3/31/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $140,338 Grant Trans-NIH Recovery Act Research Support: MAP kinase regulation of cell-fate transitions in yeast Fate determining signals establish cell-type specific programs of gene expression during development of multicellular organisms. This regulation often involves a fine balance between activation Health and Human Services, Department of / National Institutes of Health 6/11/2010
UNIVERSITY OF CALIFORNIA, DAVIS $717,770 Grant Trans-NIH Recovery Act Research Support: Molecular and Force Dynamics: Leukocyte Adhesion Molecules (ARRA) Administrative Supplement Health and Human Services, Department of / National Institutes of Health 6/04/2009
MASSACHUSETTS GENERAL HOSPITAL, THE $238,550 Grant Trans-NIH Recovery Act Research Support: Our overall goal is to better understand the growth and proliferation of white adipose tissue at a cellular level so that we might learn to alter the enlargement of this tissue and provide an effective therapy for obesity. Our main hypothesis is that the Health and Human Services, Department of / National Institutes of Health 7/05/2010
NORTHWESTERN UNIVERSITY $415,830 Grant Trans-NIH Recovery Act Research Support: Whole Genome Association Studies (GWAS) is a very powerful approach for the genetic analysis of complex traits, and interaction(s) between genetic predisposition and environment. Following the statistical analysis of high-density genome-wide association s Health and Human Services, Department of / National Institutes of Health 5/20/2010
NORTHWESTERN UNIVERSITY $100,000 Grant Trans-NIH Recovery Act Research Support: Vibrio cholerae O1 is the causative agent of pandemic cholera, a severe diarrheal disease still prevalent worldwide. The major etiologic agent of the Seventh Cholera Pandemic that began in 1961 and continues today is the cholera toxin producing El Tor O1 Health and Human Services, Department of / National Institutes of Health 4/26/2010
PPD BIOMARKER DISCOVERY SCIENCES, LLC $1,891,232 Grant Trans-NIH Recovery Act Research Support: Biomarkers for diseases of the nervous system can benefit from advanced proteomic analysis of cerebral spinal fluid (CSF) but some basis biological and analytical parameters of CSF collection, handling, and analysis must be systematically evaluated. The Health and Human Services, Department of / National Institutes of Health 4/08/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $48,383 Grant Trans-NIH Recovery Act Research Support: The unifying goals of this P01 competing renewal are to further understand the immune, esposure, and genetic basis of chronic beryllium disease (CBD) and to discover and validate biological markers of disease prognosis and therapeutic response. Health and Human Services, Department of / National Institutes of Health 5/28/2010
WASHINGTON UNIVERSITY, THE $1,198,524 Grant Trans-NIH Recovery Act Research Support: We propose the acquisition of a two-photon/confocal microscope (Zeiss LSM 710) integrated with photoacoustic microscopy (PAM) to support NIH-funded research and establish imaging capabilities for the research community on the Danforth campus at Washington Health and Human Services, Department of / National Institutes of Health 4/01/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $500,000 Grant Trans-NIH Recovery Act Research Support: This award was used to purchase and install 4 pieces of essential equipment in the UAB Fermentation Facility. Three new fermentors have been installed. 1) A BioFlo 415 Fermentor with working volumes of 9.5L - 15.5 L working volume limits will cover the Health and Human Services, Department of / National Institutes of Health 6/10/2010
MINUS K TECHNOLOGY INC $102 Contract : 3 vibration isolation units purchased from the manufacturer Health and Human Services, Department of / National Institutes of Health 9/30/2009
EMORY UNIVERSITY $519,640 Grant Trans-NIH Recovery Act Research Support: Project Title: Virologic Correlates of HIV Heterosexual Transmission The overall goal of this study is to determine whether women exposed to HIV in the semen of there husbands but do not get infected (so called exposed uninfected women) have developed an Health and Human Services, Department of / National Institutes of Health 5/17/2010
UNIVERSITY OF MISSOURI SYSTEM $157,961 Grant Trans-NIH Recovery Act Research Support: This administrative supplement requests funds to improve current facilities for recombinant protein expression and purification, and add a facility for mosquito rearing and handling in the PI's laboratory to accelerate research currently funded by NIH (R0 Health and Human Services, Department of / National Institutes of Health 4/16/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO ,THE $97,238 Grant Trans-NIH Recovery Act Research Support: The purpose of this supplement is to request funding for a new research staff position. Creating this new position will accelerate the realization of the specific aims of the parent grant. The scope of the parent grant is to investigate the key variables Health and Human Services, Department of / National Institutes of Health 4/22/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $500,000 Grant Trans-NIH Recovery Act Research Support: Spinning Disk Confocal Microscope system. Eleven Major Users and 4 Minor Users, each with ongoing NIH grant support and extensive technical experience and expertise in fluorescence microscopy, request funds to purchase a Marianas SDC spinning disk microsc Health and Human Services, Department of / National Institutes of Health 4/29/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $43,631 Grant Trans-NIH Recovery Act Research Support: This project will determine whether racial/ethnic and socioeconomic disparities in the prevalence of obesity, sedentary lifestyles and poor diet in New York City are explained by disparities in neighborhood resources that support physical activity (e.g. g Health and Human Services, Department of / National Institutes of Health 4/15/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $500,000 Grant Trans-NIH Recovery Act Research Support: Project complete; This shared instrumentation proposal is for upgrade of an existing research-dedicated General Electric 3T MRI scanner from Version 11B to Version 15. This scanner was installed in 2005 using funds from a high-end instrumentation award fr Health and Human Services, Department of / National Institutes of Health 2/18/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $145,110 Grant Trans-NIH Recovery Act Research Support: Type 1 diabetes (T1D) is an inflammatory disease of the pancreatic islets that afflicts millions of people worldwide. Although the etiological factors that trigger the disease vary, the common pathological outcome of T1D is the destruction of insulin prod Health and Human Services, Department of / National Institutes of Health 4/06/2010
NORTHWESTERN UNIVERSITY $2,866,125 Grant Trans-NIH Recovery Act Research Support: Nanoprobe for High Resolution Hard X-ray Fluorescence Microscopy (vendor X-Radia) In the interest of advancing our understanding of natural metal homeostasis in cells and tissues, as well as to detail localization, quantitation and chemical states of nano Health and Human Services, Department of / National Institutes of Health 5/06/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $96,665 Grant Trans-NIH Recovery Act Research Support: Runx2 is a master osteoblast transcription factor playing pivotal roles in skeletal development and homeostasis. In humans, Runx2 haplotypes contribute to variations in bone mass. Runx1, which is expressed in osteoblasts and shares similar DNA-binding pro Health and Human Services, Department of / National Institutes of Health 6/03/2010
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE $1,742,050 Grant Trans-NIH Recovery Act Research Support: This consortium of investigators concentrated in the Department of Chemistry at the University at Buffalo seeks to obtain a 12 Tesla Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR-MS) with electrospray ionization and imaging matrix-as Health and Human Services, Department of / National Institutes of Health 6/17/2010
PAIGE INDUSTRIAL SERVICES, INC. $147,482 Contract : Modify Animal Room- Bldg 49 Health and Human Services, Department of / National Institutes of Health 1/28/2010
UNIVERSITY OF MARYLAND $293,202 Grant Trans-NIH Recovery Act Research Support: The phylum Apicomplexa is constituted exclusively by protozoan parasites, several of which pose a significant threat to public health. The apicomplexan Plasmodium falciparum is the etiological agent of Malaria and can cause high mortality and morbidity in Health and Human Services, Department of / National Institutes of Health 4/29/2010
IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY $4,383,055 Grant Trans-NIH Recovery Act Research Support: Iowa State University proposes to bring up to accreditation standards the under-designed HVAC (heating, ventilating and air conditioning) system in 12,697 net square feet (21,162 gross square feet) of the unit called the G?Central Facility.G? Located on t Health and Human Services, Department of / National Institutes of Health 3/25/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $7,798,106 Grant Trans-NIH Recovery Act Research Support: In the last two decades, a plethora of magnetic resonance (MR) techniques, such as functional magnetic resonance imaging (fMRI), perfusion imaging, MR spectroscopy, etc. have come to play an indispensable role in biomedical research, as well as in clinica Health and Human Services, Department of / National Institutes of Health 6/10/2010
RESEARCH FOUNDATION FOR MENTAL HYGIENE INC $522,364 Grant Trans-NIH Recovery Act Research Support: To support research and other projects that will support fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments while also providing economic stimulus to the nation. Health and Human Services, Department of / National Institutes of Health 9/30/2009
RFCUNY - CITY COLLEGE $32,000 Grant Trans-NIH Recovery Act Research Support: Research Enhancement Award - Individual investigator-initiated research projects aimed at developing researchers at minority-serving institutions (MSIs) to a stage where they can transition successfully to others extramural support (R01 or equivalent). Health and Human Services, Department of / National Institutes of Health 6/28/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $499,982 Grant Trans-NIH Recovery Act Research Support: Biomedical research increasingly relies on quantitative analysis of protein dynamics in living cells to understand normal and disease behaviors. This shared equipment grant is for the acquisition of a new high-end live-cell spinning disk confocal imaging Health and Human Services, Department of / National Institutes of Health 5/27/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $160,824 Grant Trans-NIH Recovery Act Research Support: This project was initially funded as a pooling project of five cohorts of HIV-infected individuals from Western Europe and the United States. The pool of HIV cohort studies to answer pivotal questions in the management of patients with HIV infection: when Health and Human Services, Department of / National Institutes of Health 6/14/2010
SOUTHERN ILLINOIS UNIVERSITY $472,900 Grant Trans-NIH Recovery Act Research Support: The overall purpose of this award was to purchase a new flow cytometer (BD FACS Aria II) for the Flow Cytometry Core Facility at SIU School of Medicine to replace the non functional FACS Vantage purchased in 1993. The result of the award was the purchase Health and Human Services, Department of / National Institutes of Health 4/15/2010
MOUNT SINAI SCHOOL OF MEDICINE $999,999 Grant Trans-NIH Recovery Act Research Support: Human induced pluripotent cells (hiPSC) hole enormous promise for regenerative medicine. We propose to explore new methodologies to generate hiPSC without the use of transgene vectors and to develop ways to understand the kinetics, biochemistry and molecu Health and Human Services, Department of / National Institutes of Health 3/19/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $498,498 Grant Trans-NIH Recovery Act Research Support: A group of six NIH-funded cell and developmental biologists from the University of California Berkeley, together with the UC Berkeley Molecular Imaging Center (MIC), has requested funds to purchase a spinning disk confocal microscope system for real-time Health and Human Services, Department of / National Institutes of Health 5/13/2010
GEORGETOWN UNIVERSITY (THE) $1,223,446 Grant Trans-NIH Recovery Act Research Support: The Washington Metropolitan WINS (WMW) Consortium has enrolled and retained a representative cohort of HIV infected and HIV uninfected women since 1993 with the purpose of investigating the consequences of HIV infection and its treatment. Although signifi Health and Human Services, Department of / National Institutes of Health 6/14/2010
CARL ZEISS MICROIMAGING, INC. $49,803 Contract : Laboratory Equipment Health and Human Services, Department of / National Institutes of Health 4/05/2010
UNIVERSITY OF LOUISVILLE $151,331 Grant Trans-NIH Recovery Act Research Support: This funding will purchase a cell disruptor and provide support for one research associate. The purchase of the equipment allows acceleration of research results associated with the primary award. The structural maintenance of chromosomes (SMC) proteins Health and Human Services, Department of / National Institutes of Health 9/30/2009
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $500,000 Grant Trans-NIH Recovery Act Research Support: The Shared Instrumentation Grant, Purchase of Applied Biosystems QTRAP 5500 Mass Spectrometry, is to purchase the AB Sciex QTRAP 5500 mass spectrometer. It will be used for reliable quantitation of specific posttranslationally modified peptides down to t Health and Human Services, Department of / National Institutes of Health 5/06/2010
MICHIGAN STATE UNIVERSITY $27,000 Grant Trans-NIH Recovery Act Research Support: The long-term objective of this project is to understand how gene expression is regulated temporally and spatially in bacteria. Analysis of Bacillus subtilis will provide important information that also applies to other organisms, including microbial path Health and Human Services, Department of / National Institutes of Health 4/30/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $100,000 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The intertwined epidemics of obesity and diabetes have produced a public health crisis that demands an improved understanding of fat biology and metabolism. Through genetic screens in C. elegans and D. melanogaster, we Health and Human Services, Department of / National Institutes of Health 6/02/2010
SOUTHERN ILLINOIS UNIVERSITY $218,250 Grant Trans-NIH Recovery Act Research Support: Congenital pituitary hormone deficiencies occur in approximately one out of every 4,000 live births and can result in neonatal death or the failure of other glands to develop normally. Lesions in the transcription factor genes, LHX3, LHX4, RPX, PROP1, and Health and Human Services, Department of / National Institutes of Health 6/22/2010
OHIO STATE UNIVERSITY, THE $110,965 Grant Trans-NIH Recovery Act Research Support: The mammalian Mps1 protein kinase is a key regulator of centrosome duplication and is the focus of our proposed project. Centrosomes are critical for mitotic spindle assembly, and excess centrosomes lead to abnormal spindles that cannot faithfully segrega Health and Human Services, Department of / National Institutes of Health 4/09/2010
PURDUE UNIVERSITY $499,610 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Nineteen researchers in the Department of Biological Sciences and the Purdue Cancer Center at Purdue University seek support for advanced live cell imaging with a Zeiss LSM 710 confocal microscope on an inverted micros Health and Human Services, Department of / National Institutes of Health 5/06/2010
JOHNS HOPKINS UNIVERSITY, THE $428,606 Grant Trans-NIH Recovery Act Research Support: Title: UPLC with tandem MS for sensitive quantitative analysis of small molecules The ability to quantify drugs and their metabolites in cells, plasma, and tissues with high sensitivity and selectivity is an essential need of research projects that aim to Health and Human Services, Department of / National Institutes of Health 4/22/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $305,174 Grant Trans-NIH Recovery Act Research Support: This award seeks acquisition of a TOF mass spectrometer coupled with an HPLC for accurate mass determination of small molecules such as natural products, organometallic compounds, nucleic acids and non-polar organic synthetic intermediates that are genera Health and Human Services, Department of / National Institutes of Health 4/22/2010
BRANDEIS UNIVERSITY $75,600 Grant Trans-NIH Recovery Act Research Support: During the replication of many viruses, hundreds to thousands of protein subunits assemble around the viral nucleic acid to form a protein shell called a capsid. Within their host organism, most viruses form one particular structure with astonishing fidel Health and Human Services, Department of / National Institutes of Health 4/27/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $431,578 Grant Trans-NIH Recovery Act Research Support: A(1-7) stimulates hematopoietic recovery, including thrombocytopenia, and reduces mucosal lesions after intravenous chemotherapy. Stimulation of hematopoietic recovery including reduction of thrombocytopenia through increased progenitor proliferation afte Health and Human Services, Department of / National Institutes of Health 4/19/2010
MASSACHUSETTS INSTITUTE OF TECHNOLOGY $60,684 Grant Trans-NIH Recovery Act Research Support: This award is being funded with American Recovery and Reinvestment Act of 2009, as a supplement to the parent grant GM084181-02 Analysis and design of interaction specificity in proteins regulating apoptosis. The objectives of the parent award are to bett Health and Human Services, Department of / National Institutes of Health 4/16/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $90,599 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Type 2 diabetes (T2D) is a major cause of morbidity and mortality in the USA and worldwide. While T2D prevalence varies with age, sex, and population, it is estimated that in 2005, >20 million Americans suffered from T Health and Human Services, Department of / National Institutes of Health 4/15/2010
UNIVERSITY OF ILLINOIS $74,216 Grant Trans-NIH Recovery Act Research Support: This is a proposal for an administrative supplement under the NIEHS 'signature' ARRA program: Bisphenol A: Research to Impact Human Health. The parent grant is a P20 Formative Children's Environmental Health Research Center entitled: Novel Methods to Health and Human Services, Department of / National Institutes of Health 6/10/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $61,065 Grant Trans-NIH Recovery Act Research Support: One underserved group is the 4 million homeless persons in the US among whom cigarette smoking rate is an alarming 70% or more; these rates are 3 times higher than national average. Two of the three leading causes of death among homeless persons, heart di Health and Human Services, Department of / National Institutes of Health 7/27/2009
RESEARCH FOUNDATION FOR MENTAL HYGIENE INC $735,705 Grant Trans-NIH Recovery Act Research Support: This study will examine racial/ethnic disparities in terms of the dynamic longitudinal relationship between substance use and juvenile/criminal justice system involvement, and in terms of access to treatment services for substance use related problems, fr Health and Human Services, Department of / National Institutes of Health 6/01/2009
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY $153,407 Grant Trans-NIH Recovery Act Research Support: Pyrethroid pesticides are the predominant pesticide for household use along with their uses in agriculture and public health. Significant levels of pyrethroid metabolites have been found in the urine of pregnant women and in preschool children. This raise Health and Human Services, Department of / National Institutes of Health 5/16/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $229,370 Grant Trans-NIH Recovery Act Research Support: We have established a key role for X-BOX BINDING PROTEIN 1 in the immune response to F. tularensis as demonstrated by increased bacterial load of F.tularensis and decreased survival of X-BOX BINDING PROTEIN 1-/- mice to this pathogen, and believe that its Health and Human Services, Department of / National Institutes of Health 6/28/2010
JOHNS HOPKINS UNIVERSITY, THE $111,771 Grant Trans-NIH Recovery Act Research Support: PTH is the primary regulator of calcium homeostasis and bone metabolism in mammals. Its signaling system has served as a major target for the development of novel anabolic therapeutic approaches for osteoporosis. However, the exact mechanisms by which PTH Health and Human Services, Department of / National Institutes of Health 4/07/2010
NORTHWESTERN UNIVERSITY $35,800 Grant Trans-NIH Recovery Act Research Support: Reactivation of latent cytomegalovirus (CMV) is frequently observed in recipients of solid organs and bone marrow transplants and is also a significant cause of morbidity and mortality in newborns and in immunocompromised hosts. Currently available anti-v Health and Human Services, Department of / National Institutes of Health 6/21/2010
BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE $1,000,000 Grant Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (14: Stem Cells) and specific Challenge Topic (14-NS-101: Reverse Engineering Human Neurological Disease). Viral or plasmid introduction of a transcription factor quartet is proven a powerful strategy to tri Health and Human Services, Department of / National Institutes of Health 4/05/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $410,200 Grant Trans-NIH Recovery Act Research Support: Pulmonary hypertension encompasses a group of diseases characterized by high pulmonary artery pressure of unknown mechanism. While the exact pathogenesis is unclear, a common pathological feature is abnormal pulmonary vasoconstriction. One form of pulmo Health and Human Services, Department of / National Institutes of Health 8/31/2009
AXERION THERAPEUTICS, INC. $3,000,000 Grant Trans-NIH Recovery Act Research Support: Axonal Growth Therapy for neurological Recovery from Spinal Cord Injury and Stroke Health and Human Services, Department of / National Institutes of Health 4/19/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $319,949 Grant Trans-NIH Recovery Act Research Support: The overall goal of the parent grant related to this supplement is to understand the role of diacylglycerol kinases (DGKs) in T cell and mast cell biology. The experiments that we propose for this supplement extend but directly relate to this goal by dev Health and Human Services, Department of / National Institutes of Health 6/28/2010
ALAN BALL ID, INC. $199,937 Grant Trans-NIH Recovery Act Research Support: The volatility of respiratory symptoms due to asthma is related in large measure to the dynamic nature of airway obstruction in this disease. The ability to detect airway obstruction early - respiratory interoception - helps individuals with asthma to man Health and Human Services, Department of / National Institutes of Health 6/01/2010
COMPUTERBILITIES, INC $24,342 Contract : Recovery Act- Dell Laptops Health and Human Services, Department of / National Institutes of Health 6/02/2010
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK $756,673 Grant Trans-NIH Recovery Act Research Support: Project Summary Language is one of the most fundamental human cognitive abilities. It plays an important role in normal development, and is the major means for acquiring information in many domains. A number of psychological disorders (e.g., schizophrenia Health and Human Services, Department of / National Institutes of Health 7/17/2009
REGENTS OF THE UNIVERSITY OF MINNESOTA $47,519 Grant Trans-NIH Recovery Act Research Support: Human APOBEC3G is capable of altering the HIV genome by deaminating cDNA cytosines to uracils. This activity can genetically inactivate HIV. As a counter-defense mechanism, HIV promotes protein degradation of APOBEC3G. Degradation requires that the HIV vi Health and Human Services, Department of / National Institutes of Health 5/24/2010
BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON $189,956 Grant Trans-NIH Recovery Act Research Support: Our currently funded grant explores TREM-2 and DAP12 inhibition of Toll-like receptor signaling in macrophages. Aim 2 of this grant explores the signaling mechanism by which this inhibition occurs, mainly focusing on src family kinases and MAPK pathways. Health and Human Services, Department of / National Institutes of Health 6/28/2010
NORTHWESTERN UNIVERSITY $103,601 Grant Trans-NIH Recovery Act Research Support: The nucleosome is the fundamental packing unit of chromatin formed by association of DNA and histone octamer in eukaryotic chromosomes. The detailed locations of nucleosomes along genomic DNA are critical for proper gene regulation - and therefore for the Health and Human Services, Department of / National Institutes of Health 4/23/2010
JOHNS HOPKINS UNIVERSITY, THE $109,632 Contract : Tissue Repository Site for MTA and DA Health and Human Services, Department of / National Institutes of Health 3/24/2010
TENSIVE CONTROLS, INC. $199,345 Grant Trans-NIH Recovery Act Research Support: Cachexia or ?cachexia-anorexia syndrome? is a consequence of many disease states, including malignancies, bacterial and viral infections, and inflammatory conditions (e.g. rheumatoid arthritis), as well as treatments for these conditions (e.g. chemo Health and Human Services, Department of / National Institutes of Health 6/18/2010
ARIZONA STATE UNIVERSITY $637,011 Grant Trans-NIH Recovery Act Research Support: 'A novel approach will be developed to detect, quantify and identify BTEX associated with road traffic activities. The approach is designed to provide otherwise unavailable high quality chemical exposure information and serve as a tool to dramatically adv Health and Human Services, Department of / National Institutes of Health 5/01/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $81,673 Grant Trans-NIH Recovery Act Research Support: Microtubules are rigid polymers that serve a critical role in cellular architecture as structural buttresses and tracks for motor proteins. The molecular mechanisms of microtubule polymerization dynamics are not well understood, and this confounds rigorou Health and Human Services, Department of / National Institutes of Health 3/12/2010
STELLARRAY INCORPORATED $2,983,958 Grant Trans-NIH Recovery Act Research Support: Blood is routinely irradiated in hospitals and blood banks to prevent against the fatal transfusion associated graft-versus-host disease (GVHD) in certain at risk patients. A dose of 25 Gy is delivered to the blood bag with no part receiving less than 15 Health and Human Services, Department of / National Institutes of Health 6/01/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $615,898 Grant Trans-NIH Recovery Act Research Support: The Boston Area Diabetes Endocrinology Research Center (BADERC) requests funds to acquire equipment and support additional pilot and feasibility grants. The new equipment will allow the Metabolic Physiology core to service diabetes researches at more ins Health and Human Services, Department of / National Institutes of Health 5/07/2010
MAYO CLINIC $188,617 Grant Trans-NIH Recovery Act Research Support: Rheumatoid arthritis (RA) and its animal model collagen-induced arthritis (CIA) are known to be T and B cell dependent diseases. HLA-DQ8 and DRB1*0401 molecules render humans and mice susceptible to develop arthritis while DQ6 and DRB1*0402 provide protec Health and Human Services, Department of / National Institutes of Health 6/28/2010
UNIVERSITY OF KENTUCKY $99,584 Grant Trans-NIH Recovery Act Research Support: This supplementary proposal seeks to assess and likely improve the measurement of physical activity (PA), a key primary outcome of the parent grant, within our community-based sample of rural residents. Currently, the protocol for our energy balance inter Health and Human Services, Department of / National Institutes of Health 4/06/2010
UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) $147,832 Grant Trans-NIH Recovery Act Research Support: The long-term goal of this project is to elucidate how the IGF ligands, IGF-I and IGF-II, and their receptors mediate growth of the mammary gland and to determine how their function in normal tissue is related to their role in pathological states such as Health and Human Services, Department of / National Institutes of Health 4/02/2010
METROPOLITAN STATE COLLEGE OF DENVER $142,844 Grant Trans-NIH Recovery Act Research Support: This award provides supplemental instruction and is a component of Academic Support offered on an institutional basis to students in the STEPS (Strides Toward Encouraging Professions in Science) Program (Funded by the Bridges to the Future Initiative from Health and Human Services, Department of / National Institutes of Health 4/06/2010
YALE UNIVERSITY $2,300,000 Grant Trans-NIH Recovery Act Research Support: The goal of this shared instrumentation proposal is to expand the capabilities of the Yale Positron Emission Tomography (PET) Center by the acquisition of a state-of-the-art PET/CT scanner for human research studies. PET imaging provides a non-invasive me Health and Human Services, Department of / National Institutes of Health 6/17/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $105,940 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): A major signaling paradigm for modulation of hormonal and other extracellular stimuli is the use heterotrimeric G proteins by cell surface receptors. Besides direct regulation of intracellular enzymes that produce seco Health and Human Services, Department of / National Institutes of Health 6/18/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $1,011,113 Grant Trans-NIH Recovery Act Research Support: This application requests funds to purchase current-generation instrumentation for the performance of state-of- the-art peptide amide hydrogen-deuterium exchange mass spectrometry (DXMS), to replace the obsolete instrumentation presently used in the UCSD Health and Human Services, Department of / National Institutes of Health 4/15/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $318,686 Grant Trans-NIH Recovery Act Research Support: The overall goal of this proposal is to reconstitute the signaling process in space and time in cancer cells and to integrate the new experimental data into a computational model of the dynamics of the EGFR-MAPK pathway. Firstly, the components of the MAP Health and Human Services, Department of / National Institutes of Health 5/07/2009
MEDICAL COLLEGE OF WISCONSIN, INC., THE $228,000 Grant Trans-NIH Recovery Act Research Support: Chromium(VI) is used in many industries and is one of the 17 chemicals that pose the greatest risk to human health. Inhalation is a common form of exposure and causes occupational asthma, chronic bronchitis, pulmonary fibrosis, and pneumoconiosis. Lung ca Health and Human Services, Department of / National Institutes of Health 5/01/2010
BOWLING GREEN STATE UNIVERSITY (INC) $347,500 Grant Trans-NIH Recovery Act Research Support: Dysfunctions of the nuclear transport system are linked to numerous human diseases including leukemias, cancers, and primary biliary cirrhosis. Understanding of nuclear transport mechanism will directly impact our understanding and development of therapeu Health and Human Services, Department of / National Institutes of Health 3/24/2010
ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE $134,569 Grant Trans-NIH Recovery Act Research Support: Primary liver cancers are highly malignant tumors in human and their incidences are rising in the United States. The overall survival of patients with liver cancer is grim and currently no efficient chemoprevention is available. On the basis of our publis Health and Human Services, Department of / National Institutes of Health 5/27/2010
EAST CAROLINA UNIVERSITY $426,102 Grant Trans-NIH Recovery Act Research Support: N-3 polyunsaturated fatty acids (PUFA), due to their immunosuppressive effects, have great potential for the treatment of inflammatory disorders. However, the targets and mechanisms by which these fatty acids exert their effects remain poorly understood. Health and Human Services, Department of / National Institutes of Health 4/08/2010
UNIVERSITY OF ROCHESTER $499,800 Grant Trans-NIH Recovery Act Research Support: This is a proposal to establish high throughput DNA sequencing technology at the University of Rochester. The University has a rich portfolio of NIH-funded research that would benefit from access to high throughput DNA sequencing. Diverse projects, rangin Health and Human Services, Department of / National Institutes of Health 5/06/2010
UNIVERSITY OF TEXAS M D ANDERSON $308,380 Grant Trans-NIH Recovery Act Research Support: Abstract In reference to NOT-OD-09-058 (Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications), we submit this Competitive Revision to the parent grant entitled 'Tumor metastasis: Biobehavioral mechanisms Health and Human Services, Department of / National Institutes of Health 5/24/2010
UNIVERSITY OF CALIFORNIA, IRVINE $1,441,422 Contract : UC-Irvine's NIDA MTA 14-YR follow-up study modification shall address the following study objectives during the modification period: Sample retention enhancement Strengthen existing MTA subject retention by enhancing the compensation of recruitment practi Health and Human Services, Department of / National Institutes of Health 4/26/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $157,000 Grant Trans-NIH Recovery Act Research Support: The increasing incidence of obesity is a major health issue facing the USA. Moreover, the mechanisms underlying anorexia nervosa remain poorly understood. Fortunately, in the past decade several key hormones and CMS pathways controlling body weight and gl Health and Human Services, Department of / National Institutes of Health 4/12/2010
UNIVERSITY OF NORTH TEXAS $429,608 Grant Trans-NIH Recovery Act Research Support: The threat of possible bio-emergencies brought upon by pandemics or bioterrorism necessitates the development of response plans that will protect or treat the population in the affected geographic region. One of the approaches to provide necessary public Health and Human Services, Department of / National Institutes of Health 6/17/2010
SCRIPPS RESEARCH INSTITUTE, THE $499,950 Grant Trans-NIH Recovery Act Research Support: This Sl0 instrumentation award was used to purchase a hybrid linear ion trap-orbitrap mass spectrometer. The instrument will be dedicated to the study of protein dynamics using hydrogen/deuterium exchange (HDX) with a focus on the study of large protein c Health and Human Services, Department of / National Institutes of Health 4/01/2010
MARINE BIOLOGICAL LABORATORY, THE $1,535,812 Grant Trans-NIH Recovery Act Research Support: This instrument is a high end confocal microscope, to be used to probe fundamental questions in cell dynamics, questions which impact directly on public health particularly through a better understanding of development and degenerative disease. The instr Health and Human Services, Department of / National Institutes of Health 5/06/2010
LOUISIANA STATE UNIVERSITY SYSTEM $128,280 Grant Trans-NIH Recovery Act Research Support: This project supports: 1) research employment opportunities and create opportunities for Postdoctoral Fellow and Research Associate positions; 2) to purchase equipment with fluorescence microscopy that is necessary for our project. Health and Human Services, Department of / National Institutes of Health 5/10/2010
TRUSTEES OF INDIANA UNIVERSITY $60,594 Grant Trans-NIH Recovery Act Research Support: This supplement application is intended to enhance and extend the parent grant that is directed toward an assessment of the biological effects of manufactured carbonaceous nanoparticle exposure on barrier cell epithelia, materials that would be found in a Health and Human Services, Department of / National Institutes of Health 6/04/2010
TRUSTEES OF DARTMOUTH COLLEGE $1,833,339 Grant Trans-NIH Recovery Act Research Support: Funding is requested for a Bruker Avance III 700 MHz NMR spectrometer equipped with a cryogenic probe and Tecan robot for fully automated compound library screening to support the biomedical research of a consortium of investigators. NMR-based screening i Health and Human Services, Department of / National Institutes of Health 4/15/2010
UNIVERSITY OF CENTRAL FLORIDA $36,776 Grant Trans-NIH Recovery Act Research Support: An important new and rapidly growing area of research in biology involves deciphering the regulatory code used in developmental programs of higher organisms. The broad objectives of the proposed research are to gain further knowledge on the gene regulator Health and Human Services, Department of / National Institutes of Health 6/24/2010
UNIVERSITY OF UTAH, THE $489,900 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This proposal is a request for funds to purchase a Maldi/ToF/ToF mass spectrometer (Ultraflex-III, Bruker Daltonics) to upgrade the Mass Spectrometry and Proteomics Core Facility at the University of Utah. The instrume Health and Human Services, Department of / National Institutes of Health 4/01/2010
UNIVERSITY OF CALIFORNIA, IRVINE $175,855 Grant Trans-NIH Recovery Act Research Support: The fundamental aim of this supplement is to accelerate the creation and development of a National Course in Systems Biology. Supplemental funding would provide the necessary resources to recruit and retain personnel talent and significantly accelerate t Health and Human Services, Department of / National Institutes of Health 4/16/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $126,000 Grant Trans-NIH Recovery Act Research Support: Title: Lupus as a natural world model of HIV protection There is no vaccine to prevent HIV-1 infection, or to slow disease progression in infected individuals. One of the hurdles in designing such vaccines is the lack of understanding as to which immun Health and Human Services, Department of / National Institutes of Health 5/25/2010
ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE $1,763,339 Grant Trans-NIH Recovery Act Research Support: The proposed supplement consists of 6 modules. Module 1 is to purchase an upgrade to our FACSaria, which will make sorting for all of the projects more efficient. Modules 2-4 from Dr. Steinman focus on DC in an effort to develop vaccines for HIV. The new Health and Human Services, Department of / National Institutes of Health 7/06/2010
NEW YORK MEDICAL COLLEGE $34,185 Grant Trans-NIH Recovery Act Research Support: This administrative supplment supports a high school teacher to carry out research during summer 2010 with the goal of identification of novel antibacterial compounds targeting bacterial topoisomerase I. In silico screening will be carried out using newl Health and Human Services, Department of / National Institutes of Health 5/24/2010
ABASTAR MDX, INC. $200,000 Grant Trans-NIH Recovery Act Research Support: Demonstrate predictive and, consistent surrogate biomarkers to diagnose SZ with dysregulated mRNA gene expression signature from blood samples at three different time points over three months Health and Human Services, Department of / National Institutes of Health 6/22/2010
PSYCHOLOGY SOFTWARE TOOLS, INC. $2,305,646 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Cognitive dysfunction in the elderly population, ranging from simple forgetfulness to a diagnosis of Alzheimer's disease, can impact one's quality of life and ability to function in daily activities. It is crucial that Health and Human Services, Department of / National Institutes of Health 5/26/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $449,933 Grant Trans-NIH Recovery Act Research Support: Our long term goal is obtain a survey of lipid signaling paths activated during fertilization and detail their role in the induction of fertilization events. We will inhibit autotaxin activity, quantify the levels of lysophosphatidic acid (measured by HPL Health and Human Services, Department of / National Institutes of Health 4/14/2010
TECHTOWN VENTURES, INC. $200,000 Grant Trans-NIH Recovery Act Research Support: The demonstration that mature adult cells can be reprogrammed to create induced pluripotent stem cells (iPSCs), which are like embryonic stem cells with respect to their self-renewal and differentiation capacities, has sparked a great deal of interest in Health and Human Services, Department of / National Institutes of Health 5/01/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $3,737,763 Grant Trans-NIH Recovery Act Research Support: The procurement of a high end computer (HEC) resource is proposed to meet demands of a broad range of NIH-supported biomedical research groups at the University of Minnesota, driven by the need to tackle problems involving the acquisition, analysis and vi Health and Human Services, Department of / National Institutes of Health 6/10/2010
LOCKHEED MARTIN MANAGEMENT SYSTEMS DESIGNERS, INC $417,911 Contract : To ensure that all efforts in the deployment of NIH enterprise systems are focused on delivering products that effectively meet approved requirements within established budget and schedules, the services of an IV&V contractor are required. The objective Health and Human Services, Department of / National Institutes of Health 5/07/2010
DIGICON CORPORATION $279,679 Contract : PDAs and Label Printers Health and Human Services, Department of / National Institutes of Health 2/18/2010
THOMAS JEFFERSON UNIVERSITY $91,356 Grant Trans-NIH Recovery Act Research Support: This funding is specifically to support the stipend of a postdoctoral research. The key project supported by the parent grant is the role of the dSlo channel-binding protein Slob in synaptic transmission. Slob and dSlo play an especially prominent role Health and Human Services, Department of / National Institutes of Health 6/18/2010
UNIVERSITY OF ILLINOIS $488,504 Grant Trans-NIH Recovery Act Research Support: We propose to acquire an integrated computer system for large data storage, high-performance computation, and state-of-the-art visualization that links to present and next generation terascale- to-petascale computers at the national supercomputing centers Health and Human Services, Department of / National Institutes of Health 4/01/2010
YALE UNIVERSITY $159,900 Grant Trans-NIH Recovery Act Research Support: This proposal seeks to acquire a Cellvizio confocal endomicroscopic imaging system for Yale Medical School. The ongoing renaissance in the use of light microscopy for cell and molecular biology and physiology has been driven in large part by the developme Health and Human Services, Department of / National Institutes of Health 4/08/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $72,577 Contract : The Medical College of Wisconsin has been awarded a contract to provide tumor types to the NCI for the Cancer Genome Atlas project. Specifically this award is to fund the provision of 100 cervical cancer samples and 100 corresponding blood samples. Thes Health and Human Services, Department of / National Institutes of Health 3/10/2010
UNIVERSITY OF ARKANSAS SYSTEM $397,653 Grant Trans-NIH Recovery Act Research Support: A major user group of 4 University of Arkansas for Medical Sciences (UAMS) clinical research scientists, holding 7 current NIH peer?reviewed grants, request a chemical separation and analysis system comprising (a) an Applied Biosystems (AB)/Sciex QTRAP-? Health and Human Services, Department of / National Institutes of Health 4/22/2010
LIBERATING TECHNOLOGIES INC $199,686 Grant Trans-NIH Recovery Act Research Support: The purpose of the R43 award is to determine the feasibility of creating a device that can be incorporated into the prosthesis to improve the circulation in the residual limbs of persons with amputation resulting from vascular complications. The delivera Health and Human Services, Department of / National Institutes of Health 4/15/2010
WYLE INFORMATION SYSTEMS, LLC $224,680 Contract : Enhancing Peer Review Project ? will support for the Enhancing Peer Review Project that will address additional technical requirements identified by the NIH Peer Review Working Groups. These enhancements will promote the Peer Review Oversight committee?s Health and Human Services, Department of / National Institutes of Health 5/18/2010
OHIO STATE UNIVERSITY, THE $803,969 Grant Trans-NIH Recovery Act Research Support: Leishmania are obligate intracellular parasites that are transmitted by a sand fly vector and cause a wide range of diseases, such as cutaneous (Cl), mucocutaneous (MCl) and visceral leishmaniasis (Vl). Over 12 million people currently suffer from leishma Health and Human Services, Department of / National Institutes of Health 6/21/2010
SCRIPPS RESEARCH INSTITUTE, THE $515,033 Grant Trans-NIH Recovery Act Research Support: Renal transplantation is the treatment of choice for patients with renal failure, but acute and chronic allograft failure remains a critical problem for the transplant recipient. Infections are an independent factor that contributes to renal allograft fa Health and Human Services, Department of / National Institutes of Health 6/04/2010
TRUSTEES OF INDIANA UNIVERSITY $423,500 Grant Trans-NIH Recovery Act Research Support: Epidemiological studies indicate a higher prevalence of painful disorders in females than in males. Although gender-related differences are numerous, considerable evidence implicates estrogens as critical factors in sex-dependent differences in pain, espe Health and Human Services, Department of / National Institutes of Health 5/04/2010
TRUSTEES OF TUFTS COLLEGE INC $76,750 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Expansions of simple DNA repeats are implicated in nearly thirty hereditary disorders in humans. This proposal concentrates on molecular mechanisms responsible for repeat expansions. During the previously funded period Health and Human Services, Department of / National Institutes of Health 6/18/2010
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. $371,250 Grant Trans-NIH Recovery Act Research Support: Chemoresistance is a major problem in epithelial ovarian carcinoma that must be addressed to achieve a cure for this disease. In ovarian cancer, LPA is a growth factor found in patient ascites fluid that enhances tumor progression by promoting oncogenic g Health and Human Services, Department of / National Institutes of Health 6/17/2010
UNIVERSITY OF UTAH, THE $166,512 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This proposal builds on previous research that developed the dog as a model for the genetic analysis of complex traits. A working relationship with owners and breeders of Portuguese Water dogs (PW dogs) has led to a da Health and Human Services, Department of / National Institutes of Health 5/07/2010
UNIVERSITY OF MARYLAND $111,223 Grant Trans-NIH Recovery Act Research Support: This project focuses on the roles of human hyaluronidase-1 (hHyal-1) and hyaluronidase-2 (hHyal-2) in the mediation of the biological functions assumed by the extracellular matrix polysaccharide hyaluronan (HA). HA serves as the glue that binds cells toge Health and Human Services, Department of / National Institutes of Health 9/30/2009
UNIVERSITY OF ARIZONA $391,650 Grant Trans-NIH Recovery Act Research Support: This proposal requests funding for acquisition of a new, modern continuous wave (CW) X-band (~9 GHz) electron paramagnetic resonance (EPR) spectrometer, Bruker Elexsys E500 equipped with E560D electron-nuclear double resonance (ENDOR) system, to support t Health and Human Services, Department of / National Institutes of Health 6/10/2010
MAYO CLINIC $78,163 Grant Trans-NIH Recovery Act Research Support: This Recovery Act Administrative Supplement NOT-OD-09-056 to R01 DK29953 is designed to support a postdoctoral trainee and accelerate the collection of data associated with the parent award. Additionally, it provides an employment opportunity for a talent Health and Human Services, Department of / National Institutes of Health 4/19/2010
BOWDOIN COLLEGE $313,502 Grant Trans-NIH Recovery Act Research Support: Helicobacter pylori is the leading cause of duodenal ulcers and cancer worldwide. Unfortunately, existing antibiotics no longer effectively eradicate Hp and cure these ailments. The development of new treatments will be greatly aided by insights into the Health and Human Services, Department of / National Institutes of Health 4/17/2010
UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL $175,400 Grant Trans-NIH Recovery Act Research Support: Supplemental funds to carry out new, follow-up experiments not proposed in the parent NIH - NIGMS funded grant entitled Deciphering the Toxin-Antitoxin systems in E. coli. These experiments follow the original Specific Aims, however require additional eq Health and Human Services, Department of / National Institutes of Health 6/18/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $437,882 Grant Trans-NIH Recovery Act Research Support: The goal of this NCRR S10 grant proposal is to acquire a state-of-the-art laserscanning confocal microscope (Leica TCS SP5 AOBS 405UV Spectral Confocal Microscope) to support research of 14 NIH-funded investigators at the New England Primate Research Cent Health and Human Services, Department of / National Institutes of Health 5/27/2010
UNIVERSITY OF WISCONSIN SYSTEM $59,013 Grant Trans-NIH Recovery Act Research Support: Restenosis, or re-narrowing of the arterial lumen following vascular interventions to treat atherosclerosis, produces significant mortality and morbidity for thousands of individuals. Transforming growth factor-beta (TGF-2) is an important mediator of re Health and Human Services, Department of / National Institutes of Health 6/22/2010
UNIVERSITY OF MARYLAND $292,795 Grant Trans-NIH Recovery Act Research Support: A collaborative team involving investigators led by the Institute of Human Virology-University of Maryland (IHV) will identify 115 pregnant women with acute HIV infection. Our long-term goal is to advance the understanding of mother-to-child transmission Health and Human Services, Department of / National Institutes of Health 6/02/2010
UNIVERSITY OF SOUTH ALABAMA $355,059 Grant Trans-NIH Recovery Act Research Support: THE ON-GOING GOAL OF THIS PROJECT IS TO STUDY THE ROLE THAT TRANSPORT PLAYS IN THE BIOLOGY OF THE OBLIGATE INTRACYTOPLASMIC PATHOGEN, RICKETTSIA PROWAZEKII AND DEFINE HOW THIS IMPACTS INTERACTIONS WITH THE EUKARYOTIC HOST CELL. THE FOCUS OF THIS PROJECT Health and Human Services, Department of / National Institutes of Health 4/12/2010
BRIGHT CLOUD INTERNATIONAL CORP. $100,000 Grant Trans-NIH Recovery Act Research Support: This project will develop a new device and theapeutc method for training upper extremity and cognition in an integrated way providing a single-point-of-care solution. The same approach can be extended to other patient populations and age groups. The aim Health and Human Services, Department of / National Institutes of Health 5/06/2010
MOUNT SINAI SCHOOL OF MEDICINE $677,475 Grant Trans-NIH Recovery Act Research Support: The Filo, Ebola and Marburg viruses (EBOV and MARV), are NIAD category A viruses associated with outbreaks of severe viral hemorrhagic fever. FDA-approved drugs for prophylaxis or treatment of these infections are currently lacking. This project will de Health and Human Services, Department of / National Institutes of Health 6/30/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $130,403 Grant Trans-NIH Recovery Act Research Support: Cell division is an essential feature of growth, development and renewal. Each time a cell divides an exact copy of the genome must be made and each replicated chromosome equally distributed to the progeny cells. If chromosomes are unequally distributed, Health and Human Services, Department of / National Institutes of Health 4/16/2010
UNIVERSITY OF MARYLAND $298,091 Grant Trans-NIH Recovery Act Research Support: Over the past decade there has been a growing awareness of the disabling effects of impaired cognition in individuals with schizophrenia. Along with this new awareness has come an increasing emphasis on the importance of developing new treatments that may Health and Human Services, Department of / National Institutes of Health 6/29/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $94,301 Grant Trans-NIH Recovery Act Research Support: Lymphedema (hand and arm swelling) is a major source of morbidity among breast cancer survivors. Since axillary surgery results in the iatrogenic disruption and damage of lymphatic channels, it is likely that surgeon technique plays a role in the developm Health and Human Services, Department of / National Institutes of Health 9/15/2009
OREGON STATE UNIVERSITY $45,205 Grant Trans-NIH Recovery Act Research Support: Environmental polycyclic aromatic hydrocarbons (PAHs), when activated by cellular metabolism, form a variety of mutagenic and carcinogenic adducts with DNA. Cellular responses remain poorly characterized. The long- term goal of this dual-PI project is an Health and Human Services, Department of / National Institutes of Health 5/21/2010
BROAD INSTITUTE, INC., THE $85,400 Grant Trans-NIH Recovery Act Research Support: This proposal is a request for a Recovery Act Administrative Supplement for the grant 1DP2DK083048-01, a Type 1 Diabetes Pathfinder Award. This Supplement is for additional automation equipment in order to perform high-throughput screening. A primary goal Health and Human Services, Department of / National Institutes of Health 2/11/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $45,839 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to decipher molecular signaling mechanisms for control of insulin biosynthesis and secretion, and the immediate focus is on dissecting the function of Shp2 tyrosine phosphatase in orchestrating signaling cascades in ( cells. Al Health and Human Services, Department of / National Institutes of Health 6/17/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $1,295,083 Grant Trans-NIH Recovery Act Research Support: The Cardiovascular Center (CVC) at the Medical College of Wisconsin (MCW) is a Biomedical Core Center with ongoing research related to the prevention, detection, treatment and cure of the complex set of cardiovascular diseases related to heart, lung, stro Health and Human Services, Department of / National Institutes of Health 9/30/2009
THERMO FISHER SCIENTIFIC (ASHEVILLE) LLC $14,539 Contract : Laboratory Equipment Order Health and Human Services, Department of / National Institutes of Health 4/07/2010
CHILDRENS HOSPITAL OF PHILADELPHIA $329,400 Grant Trans-NIH Recovery Act Research Support: Chronic kidney disease (CKD) and its metabolic derangements substantially affect the well-being of children. In order to define the nature, magnitude, and temporal evolution of the adverse effects of progressive CKD, we propose to extend the follow-up of Health and Human Services, Department of / National Institutes of Health 6/11/2010
THE CHILDREN'S HOSPITAL OF PHILADELPHIA $99,457 Grant Trans-NIH Recovery Act Research Support: Our work focuses on the mechanisms by which transcription factors regulate the development of diverse hematopoietic lineages, and how these factors orchestrate terminal differentiation with cell cycle arrest. These functions require key nuclear factors to Health and Human Services, Department of / National Institutes of Health 5/27/2010
UNIVERSITY OF TEXAS AT AUSTIN $370,601 Grant Trans-NIH Recovery Act Research Support: The primary goal of the research in this competitive renewal application is to understand the role of signal transducers and activators of transcription (Stats), particularly Stat3, in epithelial carcinogenesis. During the previous funding period, through Health and Human Services, Department of / National Institutes of Health 5/18/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $14,920,230 Grant National Center for Research Resources, Recovery Act Construction Support: This ARRA C06 project will renovate more than 40,000 gross square feet of existing space in the heart of the UCLA biomedical campus to create the Integrative Phenotyping Center for Neuropsychiatry (IPCN). High-throughput strat... Show more Health and Human Services, Department of / National Institutes of Health 3/31/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $490,874 Grant Trans-NIH Recovery Act Research Support: A major cause of morbidity and mortality in the United States and throughout the world is infectious diseases. A major goal of the NIH is to conduct and support basic and applied research to better understand, treat, and ultimately prevent infectious dise Health and Human Services, Department of / National Institutes of Health 5/13/2010
BECTON, DICKINSON AND COMPANY $2,994 Contract : Purchase of: Service Contract for FACSCalibur Health and Human Services, Department of / National Institutes of Health 6/09/2010
UNIVERSITY OF CHICAGO, THE $470,000 Grant Trans-NIH Recovery Act Research Support: We request the Illumina Solexa GAIIx system, which will be an essential next generation sequencing platform for a wide range of NIH funded projects at the greater Chicago metropolitan area. This new machine will be housed at the High-Throughput Genomic An Health and Human Services, Department of / National Institutes of Health 4/22/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO $445,500 Grant Trans-NIH Recovery Act Research Support: Exposure to exogenous agents that damage the cell is an unavoidable and potentially deleterious component of life, though various cellular responses exist to counter these exposures. It is understood that these countermeasures are vital for both cellular Health and Human Services, Department of / National Institutes of Health 5/29/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $78,625 Grant Trans-NIH Recovery Act Research Support: Human diseases often arise from excessive or deficient transcription of particular genes in an organism. Proteins known as transcription factors (TF) regulate transcription of a gene through binding specific sites on DNA known as TF binding sites (TFBS). Health and Human Services, Department of / National Institutes of Health 4/23/2010
BETH ISRAEL DEACONESS MEDICAL CENTER INC $147,247 Grant Trans-NIH Recovery Act Research Support: African Americans comprise a higher percentage of the waiting list for kidney transplantation than would be expected based on population parameters, they wait longer for kidney transplantation, and they are far less likely to receive live donor kidney tra Health and Human Services, Department of / National Institutes of Health 5/28/2010
TRUSTEES OF INDIANA UNIVERSITY $54,818 Grant Trans-NIH Recovery Act Research Support: The requested supplement will enable one of the PIs of the parent project, Dr. Mitra, to contribute his unique expertise to the combined efforts of the newly established NIEHS NanoGO Consortium round robin testing to standardize toxicity evaluation of con Health and Human Services, Department of / National Institutes of Health 6/04/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $203,250 Grant Trans-NIH Recovery Act Research Support: Funds are requested to purchase an atomic force microscope (AFM) in order to establish the Core Laboratory for Biomedical Applications of Atomic Force Microscopy at the University of Virginia. The instrument purchased will be the Multimode V Scanning Pro Health and Human Services, Department of / National Institutes of Health 5/13/2010
SAN DIEGO STATE UNIVERSITY FOUNDATION $45,162 Grant Trans-NIH Recovery Act Research Support: A summer supplement for university students is requested under the American Recovery and Reinvestment Act. This will provide scientific instruction and temporary employment for four talented individuals. They will be trained in protein biochemistry, cryst Health and Human Services, Department of / National Institutes of Health 5/19/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $377,418 Grant Trans-NIH Recovery Act Research Support: Regulatory T cells are required to prevent the immune system from attacking itself and causing autoimmune disease such as diabetes. The studies supported by this grant will identify how a molecule called STAT5 regulates the development of regulatory T cel Health and Human Services, Department of / National Institutes of Health 6/14/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $286,500 Grant Trans-NIH Recovery Act Research Support: This is a proposal for an administrative supplement of $286,500 (direct costs) to my grant U01 AI069569-07 to accelerate the pace of generation of a vaccine product for the proposed phase I clincial studies. By supplementing the funding of this grant to Health and Human Services, Department of / National Institutes of Health 6/14/2010
UNIVERSITY OF CINCINNATI $487,434 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Temporal processing properties of the auditory system in cochlear implant users Description of the Project One of the major challenges in cochlear implants (CIs) is the large variability in CI patients' speech percepti Health and Human Services, Department of / National Institutes of Health 4/08/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $273,600 Grant Trans-NIH Recovery Act Research Support: The objective of the parent proposal is to elucidate the mechanisms whereby scleroderma increases myocardial inflammation and fibrosis, which then results in myocardial dysfunction. Matrix instability in scleroderma increases oxidative stress in the hear Health and Human Services, Department of / National Institutes of Health 7/16/2009
UNIVERSITY OF MARYLAND $99,613 Grant Trans-NIH Recovery Act Research Support: One of the most debilitating neurological complications of HIV infection is painful peripheral neuropathy (PPN) associated with nucleoside reverse transcriptase inhibitors (NRTIs). The predominant symptom, excruciating and unremitting pain, is resistant t Health and Human Services, Department of / National Institutes of Health 5/13/2010
UNIVERSITY OF WASHINGTON $190,000 Grant Trans-NIH Recovery Act Research Support: In order to halt the HIV epidemic, it is becoming increasingly important to understand the biology of HIV transmission at the sites of primary infection within the genital tract. Studies of women who are exposed to HIV yet remain uninfected may provide a Health and Human Services, Department of / National Institutes of Health 5/17/2010
THE UNIVERSITY OF AKRON $16,274 Grant Trans-NIH Recovery Act Research Support: The equipment request is for a microinjection setup that allows the trainee to view the microscope field on a video monitor (greatly facilitating training). Currently training a student how to do microinjections involves multiple trips in and out of the Health and Human Services, Department of / National Institutes of Health 6/14/2010
RESEARCH FOUNDATION FOR MENTAL HYGIENE INC $257,642 Grant Trans-NIH Recovery Act Research Support: To support research and other projects that will support fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments while also providing economic stimulus to the nation. Health and Human Services, Department of / National Institutes of Health 3/12/2010
CENTRAL MICHIGAN UNIVERSITY (INC) $408,553 Grant Trans-NIH Recovery Act Research Support: The assembly of ribonucleoprotein (RNP) complexes into microscopically visible granules occurs as part of the normal cellular regulation of RNA metabolism (processing bodies) and in response to stress (stress granules). Large RNP granules are also induce Health and Human Services, Department of / National Institutes of Health 6/04/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $203,750 Grant Trans-NIH Recovery Act Research Support: Alcohol consumption is generally thought to enhance liver fibrosis. Alcohol-induced liver fibrosis promotes formation of cirrhosis, which increases a risk of liver cancer. Cancer cells have a consistent cytological feature of nucleolar hypertrophy, enlarg Health and Human Services, Department of / National Institutes of Health 5/22/2009
CASE WESTERN RESERVE UNIVERSITY $98,170 Grant Trans-NIH Recovery Act Research Support: This Administrative Supplement application is in response to NOT-OD-09-056. The project is entitled G?Administrative Supplement: Equipment to Support Full Inclusion of Persons with Disabilities in Self-Management Research.G? Funds are for supplemental eq Health and Human Services, Department of / National Institutes of Health 5/13/2010
ORDWAY RESEARCH INSTITUTE, INC. $18,392 Grant Trans-NIH Recovery Act Research Support: This grant provided a summer research experience(s) for two college students in health-related research. Exposure to dietary carcinogens, including aflatoxin B1 (AFB1) and heterocyclic amines (HAs), poses a significant risk factor for liver and gastroint Health and Human Services, Department of / National Institutes of Health 5/21/2010
NORTH CAROLINA STATE UNIVERSITY $72,392 Grant Trans-NIH Recovery Act Research Support: This supplement is being submitted to request funding for a newly arranged collaborative project between our lab and the FDA. We are looking at the impact of gestational exposure to Bisphenol A (BPA), a chemical which leaches out of plastics, on sexually Health and Human Services, Department of / National Institutes of Health 6/04/2010
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE $48,642 Grant Trans-NIH Recovery Act Research Support: The purpose of this application is for Daniel Cukor, Ph.D. to transition to an independent investigator in the field of psychosocial nephrology. Depression in hemodialysis patients has been associated with lower quality of life, poor compliance to dietary Health and Human Services, Department of / National Institutes of Health 5/31/2010
UNIVERSITY OF MARYLAND $474,030 Grant Trans-NIH Recovery Act Research Support: We are requesting funds to purchase an Alba fluorescence lifetime imaging microscopy (FLIM) that will be housed in the University of Maryland-Baltimore Center for Fluorescence Spectroscopy (CFS), a campus-wide resource. The FLIM is a highly advanced spect Health and Human Services, Department of / National Institutes of Health 4/22/2010
RESEARCH FOUNDATION FOR MENTAL HYGIENE INC $747,755 Grant Trans-NIH Recovery Act Research Support: To support research and other projects that will support fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments while also providing economic stimulus to the nation. Health and Human Services, Department of / National Institutes of Health 6/05/2009
MEDICAL UNIVERSITY OF SOUTH CAROLINA $256,779 Grant Trans-NIH Recovery Act Research Support: This award is for a highly specialized instrumentation that provides reliable qualitative and quantitative analyses of natural sphingolipids and synthetic analogues supporting extensive cancer research. Health and Human Services, Department of / National Institutes of Health 5/06/2010
NEW YORK UNIVERSITY (INC) $469,716 Grant Trans-NIH Recovery Act Research Support: Only a fraction of the enormous potential of ionizing radiation has been described and understood at molecular and genetic levels, and much of our understanding has not yet been harnessed in modern medicine. We are proposing to acquire a new preclinical i Health and Human Services, Department of / National Institutes of Health 4/15/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $275,868 Grant Trans-NIH Recovery Act Research Support: The overall goal of the parent RO1 grant is to develop, validate and apply DSC (dynamic susceptibility contrast) MRI methods to monitor brain tumor angiogenesis (new vessel formation) and assist with development and optimization of both new and conventio Health and Human Services, Department of / National Institutes of Health 9/08/2009
FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE $218,564 Grant Trans-NIH Recovery Act Research Support: The purpose of this award is to purchase a Leica LMD7000 laser capture microdissection system. This instrument allows for the isolation of single cells or small groups of cells from thin sections of frozen or formalin-fixed paraffin-embedded archival tiss Health and Human Services, Department of / National Institutes of Health 5/06/2010
NEW YORK UNIVERSITY (INC) $171,265 Contract : The purpose of this contract is to study the long-term effects of different treatment modalities for children with attention deficit hyperactivity disorder (ADHD) through a systematic follow-up of the subjects who participated in the Multimodal Treatment Health and Human Services, Department of / National Institutes of Health 4/22/2010
YALE UNIVERSITY $931,206 Grant Trans-NIH Recovery Act Research Support: This proposal seeks to acquire a Zeiss LSM 710 Duo confocal/multiphoton fluorescence microscope for the Center for Cell and Molecular Imaging at Yale University School of Medicine. This microscope would replace the oldest of three confocal microscopes in Health and Human Services, Department of / National Institutes of Health 5/06/2010
VETERANS MEDICAL RESEARCH FOUNDATION OF SAN DIEGO $86,776 Grant Trans-NIH Recovery Act Research Support: This administrative supplement is a request for personnel to increase the tempo of research on the R01 grant HIV-1 Vpu and BST-2/CD317, by increasing the current level of research/technical support and employment on this project. Specifically, our studies Health and Human Services, Department of / National Institutes of Health 6/01/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $450,000 Grant Trans-NIH Recovery Act Research Support: The proposed system will be used for obtaining high resolution structural images of small animals which will be used for better understanding of a variety of disorders and drug developments. The scanner will be used by several groups both within the Unive Health and Human Services, Department of / National Institutes of Health 5/13/2010
WASHINGTON UNIVERSITY, THE $316,097 Grant Trans-NIH Recovery Act Research Support: Diamond Blackfan Anemia is a rare bone marrow failure syndrome characterized by red cell aplasia, congenital abnormalities and a predisposition to cancer. Heterozygous mutations in ribosomal protein genes have been found in approximately 50% of DBA patie Health and Human Services, Department of / National Institutes of Health 4/01/2010
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY $419,356 Grant Trans-NIH Recovery Act Research Support: This application requests funds to purchase a new single photon multi-fluorescence/spectral confocal laser-scanning microscope (CLSM) to be used as a shared resource for several research programs at the School of Environmental and Biological Sciences (SEB Health and Human Services, Department of / National Institutes of Health 5/06/2010
DUKE UNIVERSITY $292,500 Contract : Duke University has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of breast cancer specimens (100 cases). These cases are all primary and untreated. Health and Human Services, Department of / National Institutes of Health 4/30/2010
BECTON, DICKINSON AND COMPANY $122,376 Contract : Purchase of: FACSCanto II Flow Cytometer Health and Human Services, Department of / National Institutes of Health 6/10/2010
CHILDREN'S HOSPITAL MEDICAL CENTER $102,311 Grant Trans-NIH Recovery Act Research Support: This supplement is in accordance with NOT-OD-09-056 to create a job for a Research Assistant (RA) for a 1 year period. We are requesting a total of $102,311 for one year for this supplement request. This amount will cover the salary and supplies used in Health and Human Services, Department of / National Institutes of Health 6/28/2010
THE INSTITUTE FOR CANCER RESEARCH $21,331 Grant Trans-NIH Recovery Act Research Support: Title: The Porphobilinogen Synthase Family Abstract: Porphobilinogen synthase (PBGS; E.C. 4.2.1.24, a.k.a. 5-aminolevulinic acid dehydratase or ALAD) catalyzes the formation of the fundamental biological monopyrrole, porphobilinogen in the pathway toward Health and Human Services, Department of / National Institutes of Health 5/21/2010
TRUDEAU INSTITUTE, INC. $10,340 Grant Trans-NIH Recovery Act Research Support: The purpose of this administrative supplement is to obtain salary and a small supply budget for a college student summer research internship. The benefits to this internship are twofold, including (1) acquiring additional staff to expedite a particularly Health and Human Services, Department of / National Institutes of Health 5/24/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $194,470 Grant Trans-NIH Recovery Act Research Support: A group of researchers at the University of Colorado, Boulder, are requesting a state-of-the-art circular dichroism spectropolarimeter (CD) for biomolecular studies. CD is a key biophysical tool for the characterization of secondary and tertiary structure Health and Human Services, Department of / National Institutes of Health 4/15/2010
UNIVERSITY OF PITTSBURGH THE $18,665 Grant Trans-NIH Recovery Act Research Support: Title: The contribution of DNA interstrand crosslinks to Aging RO1 ES016114 This is a supplement to an existing RO1 from NIEHS. The purpose of the parental project is to test the hypothesis that the cellular response to crosslinking agents is determined a Health and Human Services, Department of / National Institutes of Health 5/21/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $0 Grant Trans-NIH Recovery Act Research Support: We are a group of ten NIH-funded faculty investigators from the INIA-West Consortium; three of us are at the University of Colorado Denver School of Medicine (applicant institution) and seven are at other institutions including the Scripps Research Instit Health and Human Services, Department of / National Institutes of Health 5/13/2010
THE VANDERBILT UNIVERSITY $3,450,000 Grant Trans-NIH Recovery Act Research Support: This is an application for funding for an advanced 15 Tesla magnetic resonance imaging (MRI) and spectroscopy (MRS) system for studies of mice and other small animals, to be housed at Vanderbilt University. This device will be used by over 25 established Health and Human Services, Department of / National Institutes of Health 5/20/2010
AKTIV-DRY, LLC $200,000 Grant Trans-NIH Recovery Act Research Support: Assuring the success of mass campaigns against bioterrorist or naturally occurring pathogens requires that vaccines, therapeutics, and other products are stored and ready for immediate use at the time the threat to public health is perceived. Storage is a Health and Human Services, Department of / National Institutes of Health 4/05/2010
NORTHWESTERN UNIVERSITY $489,850 Grant Trans-NIH Recovery Act Research Support: This proposal requests funds to purchase a Zeiss LSM 710 Laser Scanning Confocal Microscope for a group of 8 NIH funded major users and 5 minor users in the Department of Neurology, the Alzheimer's Center and the Neuroscience Institute at Northwestern Uni Health and Human Services, Department of / National Institutes of Health 5/27/2010
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE $197,454 Grant Trans-NIH Recovery Act Research Support: The Brooklyn WINS site is one of six clinical WIHS sites that together form the largest ongoing study of HIV infection in women in the US The WIHS in general, and the SUNY Brooklyn site in particular, have demonstrated their ability to recruit, retain and Health and Human Services, Department of / National Institutes of Health 6/01/2010
NEW YORK UNIVERSITY (INC) $168,784 Grant Trans-NIH Recovery Act Research Support: The lentivirus virion infectivity factor (Vif) is an accessory protein that is required for productive replication of the virus in primary cells and some, but not all, transformed T cell lines. HIV-1 that is genetically deficient in Vif (delta-Vif) fails Health and Human Services, Department of / National Institutes of Health 4/26/2010
JOHNS HOPKINS UNIVERSITY, THE $238,048 Grant Trans-NIH Recovery Act Research Support: Mycobacterium tuberculosis (MTB) and human immunodeficiency virus (HIV) are two pathogens that have developed a terrifyingly successful relationship. Tuberculosis accounts for up to a third of AIDS-related deaths worldwide, and nearly one quarter of death Health and Human Services, Department of / National Institutes of Health 4/12/2010
JOHNS HOPKINS UNIVERSITY, THE $139,868 Grant Trans-NIH Recovery Act Research Support: This proposal requests funds for the purchase of an AutoGenFlexSTAR DNA extraction instrument that will be dedicated to the molecular genetic and genetic epidemiology needs of four NIH-funded Major Users on the Bayview campus of the Johns Hopkins Universi Health and Human Services, Department of / National Institutes of Health 4/22/2010
UNIVERSITY OF WISCONSIN SYSTEM $320,955 Grant Trans-NIH Recovery Act Research Support: Understanding the mechanism of puberty is extremely important, as this developmental stage profoundly influences health and disease in adult life. The pubertal increase in steroid hormones modifies brain circuitry formation necessary for adolescent behav Health and Human Services, Department of / National Institutes of Health 5/24/2010
UNIVERSITY OF MONTANA SYSTEM $31,765 Grant Trans-NIH Recovery Act Research Support: This proposal will address the complex interactions between aM+? and NK within the context of the respiratory system using both invitro and in vivo models. Upon completion of these studies, we expect to establish and test the relative contibutions of spe Health and Human Services, Department of / National Institutes of Health 5/28/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $1,005,920 Grant Trans-NIH Recovery Act Research Support: Waters Synapt G2 HDMS enables structural characterization of biological molecules whose malfunction triggers and/or affects disease processes. Synapt G2 will support studies on cancer, reproductive and endocrine disorders and bacterial infections. Health and Human Services, Department of / National Institutes of Health 5/27/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $86,600 Grant Trans-NIH Recovery Act Research Support: The protozoan parasite Entamoeba histolytica causes an estimated 50 million cases of invasive disease annually. The most common manifestations of amebic infection are colonic disease and liver abscesses. Our goal is to identify novel virulence determinant Health and Human Services, Department of / National Institutes of Health 5/17/2010
A-TEK INC $120,845 Contract : *A-TEK was awarded the National Institutes of Health Clinical Center (NIH CC) Task Order to provide critical IT expertise to the NIH CC in support of implementation of their Disaster Recovery (DR) plan. A-TEK will perform Task Order level Program Managem Health and Human Services, Department of / National Institutes of Health 4/30/2010
BIOTEX, INC. $208,913 Grant Trans-NIH Recovery Act Research Support: The primary project award revolves around an exciting marriage of bioinformatics, molecular biology, and engineering and results in the ability to discriminate (genotype) bacteria (and more recently viruses and fungi) at the species and strain level in a Health and Human Services, Department of / National Institutes of Health 4/19/2010
GT UROLOGICAL, LLC $97,116 Grant Trans-NIH Recovery Act Research Support: Research and Development of an artificial urinary sphincter which includes biocompatibility, clinical and regulatory consultants to prepare, defend and implement plans developed to address concerns raised by the FDA. Health and Human Services, Department of / National Institutes of Health 4/09/2010
COMPUTER SCIENCES CORPORATION $1,502,999 Contract : 05 Health and Human Services, Department of / National Institutes of Health 2/26/2010
WILLIAM MARSH RICE UNIVERSITY $191,432 Grant Trans-NIH Recovery Act Research Support: Individual cells display stochastic variability in their responses to activating stimuli. In cells taking part in the innate immune response this variability seems very important. Cells react differently to the same stimulus, e.g. some proliferate some mo Health and Human Services, Department of / National Institutes of Health 4/09/2010
BANNER HEALTH $2,652,275 Grant Trans-NIH Recovery Act Research Support: Banner Health was the first non-university based healthcare organization to purchase a cyclotron. The resulting PET Center became a leader in brain-imaging research, a resource to researchers throughout Arizona, and a major catalyst to the development of Health and Human Services, Department of / National Institutes of Health 6/10/2010
UNIVERSITY OF TEXAS M D ANDERSON $879,122 Contract : MD Anderson Cancer Center has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of head and neck (300 cases) under delivery order HHSN26100001. These ca Health and Human Services, Department of / National Institutes of Health 6/15/2010
HEALTH RESEARCH, INC. $500,000 Grant Trans-NIH Recovery Act Research Support: A group of investigators at the Wadsworth Center are requesting funds to purchase a JEOL JEM-1400 transmission electron microscope (TEM). The major users of this instrument include five NIH-funded laboratories with extensive track records in, and whose sp Health and Human Services, Department of / National Institutes of Health 5/27/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $400,000 Grant Trans-NIH Recovery Act Research Support: Understanding the regulation of allogeneic stem cell activity in a host is a major challenge of transplantation medicine. Despite extensive investigation in this area, many fundamental issues remain unresolved. In our lab, we have focused our studies on a Health and Human Services, Department of / National Institutes of Health 6/21/2010
MATTHEWS MEDIA GROUP, INC. $3,400,000 Contract : EXPAND AND PROMOTE RESOURCES FOR NCI SMOKING CESSATION RESOURCES Health and Human Services, Department of / National Institutes of Health 4/30/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $139,875 Grant Trans-NIH Recovery Act Research Support: Several studies have suggested that Alzheimer's disease (AD), one of the most common forms of dementia, might be facilitated by anesthesia and surgery. Our recent research showed that the commonly used inhalational anesthetic isoflurane could induce caspa Health and Human Services, Department of / National Institutes of Health 4/09/2010
UNIVERSITY OF CINCINNATI $500,000 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This proposal requests funds to acquire an ultra-high-performance liquid chromatography mass spectrometry (UPLC-MS) system intended for the identification and structural characterization of nucleic acids, including tho Health and Human Services, Department of / National Institutes of Health 4/15/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $76,787 Grant Trans-NIH Recovery Act Research Support: Endocrine disrupting compounds (EDC) are hormonally active, synthetic or natural chemicals that interfere with normal functioning of the endocrine system, most notably the reproductive endocrine axis. Concern about EDC has mainly been fueled by studies th Health and Human Services, Department of / National Institutes of Health 6/04/2010
SCOTT & WHITE MEMORIAL HOSPITL $994,705 Grant Trans-NIH Recovery Act Research Support: It is vital to our nation's health that community leaders, healthcare providers and researchers, community service organizations and Seniors work together to find new solutions to address the health needs of Seniors. New solutions will come when we work t Health and Human Services, Department of / National Institutes of Health 6/04/2010
UNIVERSITY OF UTAH, THE $222,000 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This proposal requests funding to acquire an instrumented treadmill (AMTI Corp. Watertown, MA, USA, Model #SBSFIT) for purposes of quantifying ground reaction forces (GRFs). An instrumented treadmill (IT) is essential Health and Human Services, Department of / National Institutes of Health 5/20/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $36,734 Grant Trans-NIH Recovery Act Research Support: In the skeletally mature individual, hyaline articular cartilage does not heal effectively when injured and the natural progression of acquired articular cartilage defects is predictably poor, commonly culminating in joint arthrosis. Physician and patient Health and Human Services, Department of / National Institutes of Health 5/27/2010
MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE INC $99,710 Grant Trans-NIH Recovery Act Research Support: The purpose of this supplemental funding request is to acquire sufficient additional equipment to build a second widefield fluorescence recovery after photobleaching (FRAP) workstation with the ability to photoactivate proteins at 405nm. This equipment w Health and Human Services, Department of / National Institutes of Health 6/11/2010
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. $114,302 Grant Trans-NIH Recovery Act Research Support: The overall purpose of this basic research project is to study the mechanism by which host genetic variation confers differences in susceptibility to West Nile virus-induced disease. This supplement to NIAID, NIH grant R01 AI045135-09 entitled G?Functiona Health and Human Services, Department of / National Institutes of Health 5/10/2010
ROSE LI & ASSOCIATES INC $25,000 Contract : Provide comprehensive support for the Division of Behavioral and Social Research (DBSR) at the National Institute on Aging, National Institutes of Health, for science management, evaluation activities, writing/editing and document production, and informat Health and Human Services, Department of / National Institutes of Health 1/01/2010
OCULAR TRANSPLANTATION LLC $221,740 Grant Trans-NIH Recovery Act Research Support: Project Title: 'Disposable Instrument for Broader Patient Access to Vision Restoration Therapy' Th Health and Human Services, Department of / National Institutes of Health 6/10/2010
SOCIAL & SCIENTIFIC SYSTEMS, INC. $7,600,000 Contract : Lung Health Study in the Agriculture Health Study. SSS will provide support for conducting a case-cohort study of approximately 1338 currently symptomatic asthmatic cases (prevalent and incident cases) and 1508 randomly selected cohort members as controls Health and Human Services, Department of / National Institutes of Health 3/24/2010
GEORGIA TECH RESEARCH CORPORATION $105,251 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Copper is an essential trace element, which is critical to human health. The redox properties of copper require a sophisticated management to avoid oxidative damage of lipids, proteins or DNA. Therefore the cell must m Health and Human Services, Department of / National Institutes of Health 4/23/2010
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY $385,419 Grant Trans-NIH Recovery Act Research Support: Cold-adapted organisms ranging from psychrophilic bacteria to glacier ice worms respond to declining temperature by raising intracellular energy levels (i.e., ATP; 5' adenosine triphosphate), in an apparent mechanism to off-set inherent reductions in mole Health and Human Services, Department of / National Institutes of Health 6/25/2010
CHILDRENS HOSPITAL OF PHILADELPHIA $99,970 Grant Trans-NIH Recovery Act Research Support: Impaired urea synthesis and consequent hyperammonemia (HA) are common occurrences in disorders of congenital defects of the urea cycle and of fatty acid oxidation (FAO), nonalcoholic fatty liver disease (NAFLD) and/or Metabolic Syndrome (MS). Still unknow Health and Human Services, Department of / National Institutes of Health 6/17/2010
UNIVERSITY OF CALIFORNIA, SANTA CRUZ $133,138 Grant Trans-NIH Recovery Act Research Support: The primary objective of this research is to elucidate the mechanism of electron and proton transfer during the reduction of dioxygen to water by heme-copper oxidases. Our specific aims will focus on 4 problems: 1. The mechanism of the reduction of dioxyg Health and Human Services, Department of / National Institutes of Health 5/12/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $29,536 Grant Trans-NIH Recovery Act Research Support: Project Summary Excessive noise in the urban setting is a topic of increasing public health concern. Mass transit, and aging subway systems, in particular, are prime sources of urban noise. Yet the risk associated with subway noise is understudied and ris Health and Human Services, Department of / National Institutes of Health 6/04/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $500,000 Grant Trans-NIH Recovery Act Research Support: Stanford University is home to some of the world's most progressive biological and medical research. Proteomics as a research application, providing insightful answers to fundamental biological questions, is now a prerequisite. One of the cornerstones of Health and Human Services, Department of / National Institutes of Health 5/26/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $99,958 Grant Trans-NIH Recovery Act Research Support: Gene regulatory networks lay at the foundation of biological function and are responsible for driving the diverse cellular tasks required to sustain life. Developing a comprehensive description of cellular function in healthy and diseased states will req Health and Human Services, Department of / National Institutes of Health 4/16/2010
UNIVERSITY OF CONNECTICUT $442,314 Grant Trans-NIH Recovery Act Research Support: This proposal seeks funding for a powerful computer system to be shared between several research laboratories from the University of Connecticut. The NIH-supported projects encompass diverse areas of computational biology and bioinformatics. The proposed Health and Human Services, Department of / National Institutes of Health 4/22/2010
UNIVERSITY OF HAWAII SYSTEMS $68,069 Grant Trans-NIH Recovery Act Research Support: The 42 kDa processed fragment of the Plasmodium falciparum Merozoite Surface Protein 1, MSP1-42, is a leading protective human malaria vaccine currently undergoing clinical studies. Protective immunity is antibody-mediated, and directed to the C-terminal, Health and Human Services, Department of / National Institutes of Health 4/12/2010
UNIVERSITY OF DELAWARE $100,000 Grant Trans-NIH Recovery Act Research Support: Flavoproteins in Oxidative Protein Folding This award was for chemical instrumentation that has accelerated the study of enzymes that are crucial for the successful folding of proteins that are to be secreted from mammalian cells. A number of these en Health and Human Services, Department of / National Institutes of Health 5/05/2010
UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) $96,272 Grant Trans-NIH Recovery Act Research Support: We are putting together the paper-work to purchase the 72 Port Nose Only Exposure System Package (IN-TOX Products, Moriarity, New Mexico) for aerosol delivery of Mycobacterium tuberculosis to mice. The overall goals of my laboratory are to gain a better Health and Human Services, Department of / National Institutes of Health 4/19/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $233,203 Grant Trans-NIH Recovery Act Research Support: We have proposed to define the contribution of the major histocompatibility complex (MHC) genomic region to the risk of rheumatoid arthritis (RA). During the past five years we have made substantial progress as part of our parent grant, including completi Health and Human Services, Department of / National Institutes of Health 6/28/2010
LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE INC $14,297 Grant Trans-NIH Recovery Act Research Support: Atherosclerosis, an Inflamniatory disease associated with the production of arterial plaques, is the leading cause of morbidity and mortality worldwide. Plaque rupture commonly leads to clinical outcomes such as stroke or acute myocardial infarction (AMI) Health and Human Services, Department of / National Institutes of Health 5/28/2010
CASE WESTERN RESERVE UNIVERSITY $238,652 Grant Trans-NIH Recovery Act Research Support: Osteoarthritis (OA) is the most common musculoskeletal disease among the aging population in the United States and throughout the world. OA is characterized by degeneration of articular cartilage of the joints in hands, knees, spine and hips. While condit Health and Human Services, Department of / National Institutes of Health 5/04/2010
APPLIED BIOSYSTEMS, LLC $7,432 Contract : LABORATORY EQUIPMENT AND SUPPLIES Health and Human Services, Department of / National Institutes of Health 3/22/2010
JOHNS HOPKINS UNIVERSITY, THE $32,472 Grant Trans-NIH Recovery Act Research Support: ?Maturation functions of the HSV-1 tegument?. Herpes simplex virus (HSV) assembles an icosahedral capsid and packages this structure with the viral genome in the nucleus. It then has to exit the nucleus using a complex envelopment/de-envelopment pathway t Health and Human Services, Department of / National Institutes of Health 5/24/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $134,303 Grant Trans-NIH Recovery Act Research Support: This machine could greatly facilitate DNA methylation analysis by a broad range of investigators, and would especially benefit those who are interested in human disease but are not DNA methylation experts. Health and Human Services, Department of / National Institutes of Health 4/01/2010
CHICAGO STATE UNIVERSITY $91,537 Grant Trans-NIH Recovery Act Research Support: This administrative supplement to the Chicago State University MBRS-SCORE program funds the replacement of obsolete and/or inoperative capital equipment used in a NIH-funded MBRS-SCORE research program at a minority-serving university. The acquisition of Health and Human Services, Department of / National Institutes of Health 12/01/2009
THE VANDERBILT UNIVERSITY $364,297 Grant Trans-NIH Recovery Act Research Support: Recent studies have uncovered potential links between the novel human gammaretrovirus Xenotropic murine leukemia virus-related virus (XMRV) with disease (REF). The pathogenic potential of this virus gives rise to the need for investigating specific proper Health and Human Services, Department of / National Institutes of Health 5/24/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $233,178 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to create a conditional knock out of the Brd2 gene in order to study its function in the germ line. To minimize compromising the gene+?G??G??s function, we inserted the two recombination (loxP) sites into the non-conserved regi Health and Human Services, Department of / National Institutes of Health 5/14/2010
DISCOVERY LOGIC, INC. $2,500 Contract : Job Title: Analyst. Contract awarded to incorporate analysis of ARRA funding iniatives into larger NIH Human Subjects Research Ethics portfolio analysis. Health and Human Services, Department of / National Institutes of Health 6/11/2009
WAYNE STATE UNIVERSITY (INC) $425,329 Grant Trans-NIH Recovery Act Research Support: This proposal is for a new Q-TRAP 4000 LC-MS/MS system, both to enhance the existing capabilities of our mass spectrometry resources and eventually to replace the aging QuattroLC that is currently being used. Health and Human Services, Department of / National Institutes of Health 4/22/2010
UNIVERSITY OF ILLINOIS $35,000 Grant Trans-NIH Recovery Act Research Support: This grant awarded funds to either replace old and obsolete instruments in the lab or are specialized items that are required for the new protocols. The purchase of these items enables the research to be carried out more effectively and also stimulates th Health and Human Services, Department of / National Institutes of Health 6/14/2010
UNIVERSITY OF ROCHESTER $428,203 Grant Trans-NIH Recovery Act Research Support: Confocal microscopy has become a fundamental tool in biomedical research in recent years, thanks to advances in imaging technology that allow for obtaining images of extremely high resolution and quality from various types of tissues and cells. This pro Health and Human Services, Department of / National Institutes of Health 6/24/2010
WASHINGTON UNIVERSITY, THE $100,001 Grant Trans-NIH Recovery Act Research Support: This supplement award is to enhance research in the parent project: Ihh Signaling in Osteoblast differentiation. This project requires a large number of mouse matings, genotyping and in situ hybridization. This supplement is to support an additional tech Health and Human Services, Department of / National Institutes of Health 4/02/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $194,400 Grant Trans-NIH Recovery Act Research Support: Most men assume they will be able to conceive a child with no difficulty. However, 10-20% of all couples attempting pregnancy are infertile, with male factor infertility accounting for 40-50% of the cases. For most male infertility cases, the etiology is Health and Human Services, Department of / National Institutes of Health 5/10/2010
NEW YORK UNIVERSITY $231,000 Grant Trans-NIH Recovery Act Research Support: This supplement provides project support, both for personnel and equipment, to accelerate the pace of the research. This research will investigate how a protein hormone (parathyroid hormone, PTH) is able to interact with a cell's surface and transmit sig Health and Human Services, Department of / National Institutes of Health 4/12/2010
MEDICAL UNIVERSITY OF SOUTH CAROLINA $146,093 Grant Trans-NIH Recovery Act Research Support: The overriding purpose of the project is to improve kidney transplant outcomes in terms of graft survival and improve the economic impact of kidney transplantation. Many kidney allografts are lost in the long term because the patients lose their Medicare Health and Human Services, Department of / National Institutes of Health 5/28/2010
MIAMI UNIVERSITY $425,587 Grant Trans-NIH Recovery Act Research Support: This proposal describes studies to probe structural changes in an enzyme during the course of its biochemical reaction. We propose to utilize rapid-freeze quench (RFQ) coupled with several spectroscopic techniques to probe the reaction of metallo-?-lactam Health and Human Services, Department of / National Institutes of Health 5/24/2010
UNIVERSITY OF ARIZONA $90,055 Grant Trans-NIH Recovery Act Research Support: Acute lymphoblastic leukemia (ALL) is the most prevalent cancer among children and adolescents less than 15 years of age. Central nervous system (CNS) treatment with intrathecal and intravenous methotrexate is an essential part of ALL therapy because the Health and Human Services, Department of / National Institutes of Health 5/13/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $425,660 Grant Trans-NIH Recovery Act Research Support: The Acute Liver Failure Study Group (ALFSG) has been funded by NIDDK since 1997 to study a rare condition, acute liver failure. Only a network approach will capture these unusual but life threatening cases. ALFSG provides a registry including data and bio Health and Human Services, Department of / National Institutes of Health 5/31/2010
DUKE UNIVERSITY $59,966 Grant Trans-NIH Recovery Act Research Support: Radiation exposure from a nuclear accident or potential terrorist attack can cause death from acute injury or from late effects of radiation. Studies of the survivors of the atomic bomb at Hiroshima reveal that many radiation-induced deaths occurred years Health and Human Services, Department of / National Institutes of Health 5/10/2010
GENE THERAPY SYSTEMS, INC. $113,728 Contract : The Parent award is entitled Screening Complete TB Proteome for Protective Antigens. As part of this research, we have identified a number of candidate antigens that would also serve as a diagnostic test for TB. One concern going forward is whether our Health and Human Services, Department of / National Institutes of Health 4/26/2010
UNIVERSITY OF MISSISSIPPI $13,915,445 Grant National Center for Research Resources, Recovery Act Construction Support: The objective of this project is the completion of the construction of the University of Mississippi's National Center for Natural Products Research (NCNPR) Phase II research wing. This will entail addition of the top two flo... Show more Health and Human Services, Department of / National Institutes of Health 4/01/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $493,756 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Next-generation sequencing (NGS) provides a powerful new technology to rapidly and effectively interrogate DNA sequence in a simple, comprehensive and cost-effective manner. Probing patterns of whole genome expression, Health and Human Services, Department of / National Institutes of Health 5/27/2010
MISSOURI SYSTEM, UNIVERSITY OF $32,845 Grant Trans-NIH Recovery Act Research Support: Asthma has been increasing in prevalence and severity for unknown reasons. Though our understanding of the pathophysiology remains poor, it is widely accepted that asthma is an inflammatory disease and CD4+ T cells elaborating Th2 cytokines have been iden Health and Human Services, Department of / National Institutes of Health 5/24/2010
WASHINGTON UNIVERSITY, THE $121,776 Grant Trans-NIH Recovery Act Research Support: Globally, resistance to antimicrobial agents is on the rise, and new antimicrobial agents are urgently needed to counter severe human pathogens such as malaria and resistant bacteria. Translational efforts towards drug development depend on high-throughpu Health and Human Services, Department of / National Institutes of Health 4/08/2010
TRUSTEES OF TUFTS COLLEGE INC $4,285 Grant Trans-NIH Recovery Act Research Support: This supplement builds on an on-going, NIEHS-funded, R01 investigation of health effects in people exposed to near-highway air pollution (ES015462; referred to herein as ?CAFEH? - Community Assessment of Freeway Exposures and Health). CAFEH is an observa Health and Human Services, Department of / National Institutes of Health 6/04/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $963,205 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This proposal requests a Thermo Fisher Scientific LTQ Orbitrap Velos mass spectrometer system that will be utilized in projects important to human health, for example: pathogenesis of neuro-AIDS, tuberculosis, malaria Health and Human Services, Department of / National Institutes of Health 6/10/2010
UNIVERSITY OF CONNECTICUT $8,424 Grant Trans-NIH Recovery Act Research Support: Reading disability (RD) or dyslexia is the most common learning disorder in children. While the specific causes of dyslexia are not yet known, recent genetic and neurobiological studies strengthen a working hypothesis that dyslexia is caused by early deve Health and Human Services, Department of / National Institutes of Health 5/03/2010
YALE UNIVERSITY $428,385 Grant Trans-NIH Recovery Act Research Support: We are requesting funds for the acquisition of a BD FACSAria II Cell-sorting instrument. The researchers on the Science Hill campus of Yale University have extensive microscopy experience for their cell, stem cell and developmental biology research progra Health and Human Services, Department of / National Institutes of Health 5/20/2010
UNIVERSITY OF PITTSBURGH THE $34,084 Grant Trans-NIH Recovery Act Research Support: This application is a supplement requesting additional support for R-01 DK 51081. Briefly, as described in the original application which received a percentile score of 4th percentile, this proposal supports a head-to-head trial of the best (and only) co Health and Human Services, Department of / National Institutes of Health 6/28/2010
JOSLIN DIABETES CENTER, INC. $159,909 Grant Trans-NIH Recovery Act Research Support: G?Targeting Inflammation in Type 2 Diabetes: Clinical Trial using Salsalate Stage 2G? Chronic inflammation may participate in the pathogenesis of insulin resistance and type 2 diabetes (T2D). Anti-inflammatory effects of high-dose salicylates might there Health and Human Services, Department of / National Institutes of Health 6/15/2010
UNIVERSITY OF UTAH, THE $103,002 Grant Trans-NIH Recovery Act Research Support: This proposal is directed at a better understanding of how organisms adapt to nutrient excess and how that may contribute to type 2 diabetes. The hexosamine biosynthesis pathway (HBP) serves a nutrient sensing function. In the short term HBP signaling pro Health and Human Services, Department of / National Institutes of Health 6/07/2010
CHARLES DREW UNIVERSITY OF MEDICINE AND SCIENCE $48,000 Grant Trans-NIH Recovery Act Research Support: Charles R. Drew University of Medicine and Science proposes to co-sponsor Renal Disease in Minority Populations and Developing Nations, a satellite conference to the World Congress of Nephrology (WCN). The meeting will focus on renal disease in minority p Health and Human Services, Department of / National Institutes of Health 5/20/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $132,355 Grant Trans-NIH Recovery Act Research Support: This instrumentation proposal is for the ElectroPuls E3000 Electrodynamic Test System (Instron Corp, Norwood, MA, USA). The proposed system will provide critical new capabilities to the Structure-Function Biomechanics Core in the Penn Center for Musculos Health and Human Services, Department of / National Institutes of Health 5/13/2010
EASTERN MICHIGAN UNIVERSITY $431,807 Grant Trans-NIH Recovery Act Research Support: Cancer cells have a high level of genetic instability. Naturally occurring 'fragile sites' on human chromosomes are correlated with genetic instability in cancer cells, but it is not well understood how and why these fragile sites generate instability. Health and Human Services, Department of / National Institutes of Health 4/26/2010
SOUTH CAROLINA RESEARCH FOUNDATION $421,091 Grant Trans-NIH Recovery Act Research Support: Social Networks and Pathways to Transplant Parity for Black Hemodialysis Patients The overarching goal of the research proposed in this application is to expand the body of knowledge regarding the role of social network relationships in helping black hemo Health and Human Services, Department of / National Institutes of Health 5/27/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON $97,590 Grant Trans-NIH Recovery Act Research Support: This supplement is for equipment to support the processing, storage, and analysis of samples collected for the parent grant, Depressive Symptoms and Genetic Influences on Cardiac Outcomes (1R01NR010235). The parent grant focuses on defining the subgroup o Health and Human Services, Department of / National Institutes of Health 5/13/2010
WASHINGTON UNIVERSITY, THE $99,230 Grant Trans-NIH Recovery Act Research Support: Research supported by the requested ARRA administrative supplement will be used to test the central hypothesis of the parent grant: that R7BP functions as a palmitoylation-regulated trafficking protein for heterodimers consisting of Gbeta5 and any member Health and Human Services, Department of / National Institutes of Health 6/04/2010
UNIVERSITY OF NEBRASKA $461,102 Grant Trans-NIH Recovery Act Research Support: The Confocal Microscopy Core Facility (CMCF) is housed in the Durham Research Center (DRC), which opened in 2006. The CMCF was initiated at UNMC in 1996 and has served the research goals of >80 scientists since then. It is used extensively by scientists f Health and Human Services, Department of / National Institutes of Health 5/20/2010
EMORY UNIVERSITY $155,000 Grant Trans-NIH Recovery Act Research Support: AWARD TITLE : INNATE IMMUNITY AND SIV INFECTION The primary objective of the studies proposed herein is to obtain sufficient preliminary data that can serve as a foundation for the formulation of hypothesis based questions as part of a regular RO1 applica Health and Human Services, Department of / National Institutes of Health 5/10/2010
MOUNT SINAI SCHOOL OF MEDICINE $100,000 Grant Trans-NIH Recovery Act Research Support: Oculodentodigital dysplasia (ODDD) is a syndrome with an autosomal dominant pattern of inheritance, high penetrance, and variable expressivity. The phenotype includes dental, craniofacial, ocular, hand, and foot abnormalities. Central nervous system signs Health and Human Services, Department of / National Institutes of Health 6/14/2010
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK $80,170 Grant Trans-NIH Recovery Act Research Support: Accurate health-related quality of life (HRQOL) measurement is a critical aspect of assessing health, and the success of health care interventions. However, psychological research indicates that memory-based methods, typical of HRQOL assessment, are often Health and Human Services, Department of / National Institutes of Health 5/11/2010
OHIO STATE UNIVERSITY, THE $152,500 Grant Trans-NIH Recovery Act Research Support: Owing to the increase in obesity, life expectancy may start to decrease in developed countries for the first time. Environmental factors are increasingly found to be associated with the development of obesity. To investigate if air pollution exposure cont Health and Human Services, Department of / National Institutes of Health 7/01/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $2,299,500 Grant Trans-NIH Recovery Act Research Support: 3T/DNP grant: The objective of this proposal is to purchase a new high-performance dynamic nuclear polarizer (DNP) and specialized components for acquiring cutting edge anatomic, physiological and metabolic imaging data for evaluating novel therapeutics. Health and Human Services, Department of / National Institutes of Health 6/03/2010
JOHNS HOPKINS UNIVERSITY, THE $45,900 Grant Trans-NIH Recovery Act Research Support: Community Partnerships for Child Safety: This project aims to prevent Injuries to Children in Baltimore City by building on ongoing community work: a) Johns Hopkins CARES (Children ARE Safe) mobile resource center; b) Baltimore City Fire Department neighb Health and Human Services, Department of / National Institutes of Health 5/03/2010
LOUISIANA STATE UNIVERSITY SYSTEM $366,250 Grant Trans-NIH Recovery Act Research Support: V+?14 invariant natural killer T (V+?14iNKT) cell is a unique subset of thymic-derived innate T cells that express T cell receptor (TCR) and NK cell markers. Unlike conventional T cells, V+?14iNKT cells respond to glycolipid antigen presented by CD1d expr Health and Human Services, Department of / National Institutes of Health 6/21/2010
COGNITION THERAPEUTICS, INC. $198,376 Grant Trans-NIH Recovery Act Research Support: Small Molecule Oligomer Formation Inhibitors Health and Human Services, Department of / National Institutes of Health 6/15/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $999,440 Grant Trans-NIH Recovery Act Research Support: American Indians and Alaska Natives (AI/ANs) suffer from marked health disparities when compared to other Americans; mortality rates associated with substance use, accidents, diabetes, homicide, and suicide are unacceptably high. While making health servi Health and Human Services, Department of / National Institutes of Health 6/21/2010
UNIVERSITY OF ARIZONA $76,316 Grant Trans-NIH Recovery Act Research Support: Metals such as silver and copper are used as broad spectrum biocides in a variety of modern clinical and environmental. However, microorganisms have resistance systems that enhance survival in environments with elevated levels of metals, which counter eff Health and Human Services, Department of / National Institutes of Health 4/09/2010
YALE UNIVERSITY $491,747 Grant Trans-NIH Recovery Act Research Support: The Yale University, W.M. Keck Biotechnology Resource Laboratory's MS and Proteomics Core has developed a state-of-the-art proteomic technology to maximally support Bench-to-Bedside Research. This new service entitled targeted proteomics utilizes an emerg Health and Human Services, Department of / National Institutes of Health 5/27/2010
UNIVERSITY OF TEXAS AT AUSTIN $747,178 Grant Trans-NIH Recovery Act Research Support: This is a proposal from 5 investigators in the School of Biological Sciences at the University of Texas at Austin requesting purchase of a confocal/two-photon microscope. These investigators, the Major Users, will use this state-of-the-art microscope to f Health and Human Services, Department of / National Institutes of Health 4/22/2010
THE NATIONAL CENTER FOR GENOME RESOURCES $402,319 Grant Trans-NIH Recovery Act Research Support: Plasma Protein Biomarker-based Diagnostics of Outcome in Sepsis and CAP Health and Human Services, Department of / National Institutes of Health 4/12/2010
S. A. C. N. A. S. $159,257 Contract : With the generous support of NIGMS over the past two decades SACNAS has already maximized services and programs for underrepresented minorities beyond the annual conference, and more recently to incorporate year round initiatives such as the SACNAS Leader Health and Human Services, Department of / National Institutes of Health 9/30/2009
CASE WESTERN RESERVE UNIVERSITY $5,338 Grant Trans-NIH Recovery Act Research Support: Hepatitis C virus (HCV) is the most common cause of chronic viral hepatitis in the United States. Depending on route of HIV transmission, 9%-80% of HIV infected individuals are coinfected with HCV. HIV infection appears to alter the course of HCV related Health and Human Services, Department of / National Institutes of Health 5/24/2010
NEW MEXICO STATE UNIVERSITY $313,840 Grant Trans-NIH Recovery Act Research Support: The development of heterogeneous excited state-dependent sorting and analysis cytometry (HESAC) is poised to directly address two issues that burden intensity-based cytometry measurements: (1) uncertainties surrounding cellular autoflorescence and the ex Health and Human Services, Department of / National Institutes of Health 3/29/2010
TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER RESEARCH $497,026 Grant Trans-NIH Recovery Act Research Support: The goal of this proposal is to obtain funds for a Leica TCS SP5 MP Fixed stage (UV- VIS-IR) confocal microscope for the Baylor College of Dentistry (BCD) light microscopy core facility. This instrument will be used to examine the gene expression and prot Health and Human Services, Department of / National Institutes of Health 4/22/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $346,203 Contract : In any follow-up study, retention of the sample is one of the highest priorities. The NIDA MTA has a current retention of 78%, on the border of acceptability. It would be desirable to increase the retention by luring back some who have indicated they are Health and Human Services, Department of / National Institutes of Health 4/29/2010
MANAGEMENT SOLUTIONS, INC. $3,772,584 Contract : Provide Support Services for NIH ARRA Construction Program and Projects: Provide personnel and professional consultation services in support of the National Institutes of Health (NIH) Office of Research Facilities (ORF) ARRA Program. The intent and expec Health and Human Services, Department of / National Institutes of Health 5/11/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $4,060,337 Grant Trans-NIH Recovery Act Research Support: Our aims are to examime 1 Genome-wide single nucleotide polymorphism analysis and 2 Fat, metabolism and liver fibrosis. Purpose: Grant 1 is to facilitate 35 genetic studies in the Womens HIV Study (WIHS) and to test human genetics hypotheses by improving Health and Human Services, Department of / National Institutes of Health 6/28/2010
CEDARS-SINAI MEDICAL CENTER $46,364 Contract : The Cedars-Sinai Medical Center has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of endometrial cases. These cases are all primary and untreated. Health and Human Services, Department of / National Institutes of Health 4/06/2010
MONELL CHEMICAL SENSES CENTER $28,167 Grant Trans-NIH Recovery Act Research Support: This Administrative Supplement was provided under the parent grant, Mapping Adiposity Genes in Mice. The goal of the parent grant is to find the identity of Adip5, a quantitative trait locus on chromosome 9 that determines the weight of a specific adipos Health and Human Services, Department of / National Institutes of Health 4/12/2010
GEORGETOWN UNIVERSITY (THE) $4,671,189 Grant Trans-NIH Recovery Act Research Support: The Division of Comparative Medicine (DCM) is the sole centralized animal resource core facility at Georgetown University. The mission of the facility is to provide optimal husbandry and veterinary care, specialized technical support and appropriate regul Health and Human Services, Department of / National Institutes of Health 4/21/2010
UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE $451,795 Grant Trans-NIH Recovery Act Research Support: Award Title: Biopsychosocial determinants of weight gain in Black first-year college women Description, Objectives, & Purpose: In light of ongoing health disparities in obesity among African American women, researchers are concerned with identifying modi Health and Human Services, Department of / National Institutes of Health 5/21/2010
FISHER BIOSERVICES, INC. $1,132,014 Contract : Expansion of the NIDDK Biosample Repository Health and Human Services, Department of / National Institutes of Health 4/12/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO $36,880 Grant Trans-NIH Recovery Act Research Support: Nurses represent the single largest group of health professionals that delivers hospital care, yet little is known about what nurses do within a system context to ensure that care is safe, beneficial, patient-centered, timely, efficient and equitable. Qua Health and Human Services, Department of / National Institutes of Health 5/20/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $224,025 Grant Trans-NIH Recovery Act Research Support: The original aims of the grant remain the same: 2.1. Specific Aim 1: To characterize the epitopes recognized by HIV-1 protease and LINE specific T cells in HIV-1 exposed uninfected subjects. 2.2 Specific Aim 2: To determine the efficacy of anti-HIV-1 prot Health and Human Services, Department of / National Institutes of Health 5/17/2010
TRINITY UNIVERSITY $202,204 Grant Trans-NIH Recovery Act Research Support: The overarching goal of this proposal is to apply and develop a class of stochastic models known as general branching processes for various biological/biomedical applications that involve cellular population dynamics. There is a great need for mathematic Health and Human Services, Department of / National Institutes of Health 4/23/2010
UNIVERSITY OF PITTSBURGH THE $653,694 Contract : The Multimodal Treatment Study of Children with ADHD (MTA) is a multi-center longitudinal follow up study of children treated for ADHD. The MTA study initially enrolled 579 children with ADHD at ages 7 to 9, at seven sites, for a randomized trial comparin Health and Human Services, Department of / National Institutes of Health 4/22/2010
ASH STEVENS INC. $300,000 Contract : ARRA Funding in support of Cancer Pathway Dissection and Combination Therapies. This project is intended to be involved in helping the NCI to build a collection of small molecules of varying structural types and diversity that have drug like propert Health and Human Services, Department of / National Institutes of Health 8/04/2010
JOHNS HOPKINS UNIVERSITY, THE $495,330 Grant Trans-NIH Recovery Act Research Support: This award is for the purchase of a high accuracy quadrupole time-of-flight (QTOF) mass spectrometer with high resolution, high sensitivity and fast duty cycle to assist a productive group of investigators at Johns Hopkins University School of Medicine an Health and Human Services, Department of / National Institutes of Health 5/27/2010
SYMBION DISCOVERY INCORPORATED $199,720 Grant Trans-NIH Recovery Act Research Support: Trunkamide is a naturally occurring cyanobactin isolated from Ascidians that has known potent anticancer activity. In this project, the trunkamide pathway will be used as the basis to optimize and validate Symbion Discovery?s Evolutionary Optimization ap Health and Human Services, Department of / National Institutes of Health 6/15/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $500,000 Grant Trans-NIH Recovery Act Research Support: This application requests partial funding for the purchase of a dedicated brain Positron Emission Tomography (PET) NeuroPET scanner from PhotoDetection Systems Inc (PDS). This equipment will be part of the dedicated research PET imaging facility located w Health and Human Services, Department of / National Institutes of Health 4/15/2010
MAX MOBILITY, LLC $200,000 Grant Trans-NIH Recovery Act Research Support: Over half of the wheelchair user population has developed upper extremity (UE) pain and injury. One of the activities that likely contribute to the development of injury is wheelchair propulsion. The PVA Clinical Practice Guidelines for the Preservation o Health and Human Services, Department of / National Institutes of Health 4/01/2010
BAYLOR COLLEGE OF MEDICINE $12,341 Grant Trans-NIH Recovery Act Research Support: The purpose of this project is to define the molecular mechanisms of Cytochrome P4501A1 expression by polyclcyclic aromatic hydrocarbons (PAHs), in relation to carcinogenesis. Polycyclic aromatic hydrocarbons (PAHs) are present in cigarette smoke, particu Health and Human Services, Department of / National Institutes of Health 5/21/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $466,012 Grant Trans-NIH Recovery Act Research Support: A new state-of-the-art matrix-assisted laser desorption ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) mass spectrometer with capabilities for detecting, sequencing, and imaging proteins directly from tissue and other surfaces will be purchased. Health and Human Services, Department of / National Institutes of Health 4/01/2010
ST. JUDE CHILDREN'S RESEARCH HOSPITAL $500,000 Grant Trans-NIH Recovery Act Research Support: With the recent addition of a cyclotron and radiochemistry facility to our Nuclear Medicine Division, St Jude Children's Research Hospital investigators now have access to a wide variety of both known and novel radiotracers for positron emission tomograph Health and Human Services, Department of / National Institutes of Health 6/17/2010
WASHINGTON METROPOLITAN AREA TRANSIT AUTHORITY $54,209 Contract : These ARRA funds provided SmartBenefits on SmarTrip cards to NIH employees that they may use to ride MetroBus or MetroRail. The fare media may also be used on DASH, Ride On, Fairfax Connector, ART, CUE, Loudoun County Transit, Omniride, TheBus, DC Circula Health and Human Services, Department of / National Institutes of Health 4/21/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $1,000,000 Grant Trans-NIH Recovery Act Research Support: Effective and safe delivery of an agent with anti inflammatory, antioxidant and anti fibrotic properties would have clear value in radiation pneumonopathy. Our preliminary data shows robust protection by whole grain flaxseed from radiation induced lung fi Health and Human Services, Department of / National Institutes of Health 6/14/2010
ALCHEM LABORATORIES CORP $21,000 Contract : Synthesis of 10-15 g of NSC D740482-G (CAS 918504-65-1) Health and Human Services, Department of / National Institutes of Health 4/21/2010
ACETAMINOPHEN TOXICITY DIAGNOSTICS $89,043 Grant Trans-NIH Recovery Act Research Support: The award is for the purchase of equipment that will facilitate the production of dipstick reagents for the development of a point of care test for the diagnosis of acetaminophen toxicity. The award includes funds for the purchase of a CouloChem electroc Health and Human Services, Department of / National Institutes of Health 4/15/2010
POLYWELL COMPANY, INC. $54,249 Contract : P175824 TANGENT FLO CARTS TANGENT RUGGED MINI GM 1760 DUAL 19 MONITOR Health and Human Services, Department of / National Institutes of Health 5/25/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $157,000 Grant Trans-NIH Recovery Act Research Support: Memory T cells specific for donor antigens present a unique challenge in transplantation. While memory T cells augment host protection upon re-infection, donor-reactive memory T cells lead to robust immune responses to a transplanted organ translating int Health and Human Services, Department of / National Institutes of Health 6/28/2010
MASSACHUSETTS INSTITUTE OF TECHNOLOGY $1,415,803 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Two photon excitation offers significant advantages over other types of microscopy-based imaging, especially for imaging living cells either in vivo or in thick slices. Indeed, the technology underlying two photon imag Health and Human Services, Department of / National Institutes of Health 5/13/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $101,351 Grant Trans-NIH Recovery Act Research Support: The principal component of the translation machinery, and the integration point for regulation of protein synthesis is the ribosome, a two-subunit, RNA-protein enzyme. In concert with RNA and protein translation factors, the ribosome converts messenger RN Health and Human Services, Department of / National Institutes of Health 4/08/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $320,708 Grant Trans-NIH Recovery Act Research Support: Protein Interactions and changes in conformation govern all aspects of cellular function, and disordered protein interactions or changes in conformation lay at the basis of many human diseases ranging from the initiation of inflammation to chronic neurode Health and Human Services, Department of / National Institutes of Health 4/29/2010
JOHNS HOPKINS UNIVERSITY, THE $272,969 Grant Trans-NIH Recovery Act Research Support: In this Request for Leica High-pressure Freezer and Automated Freeze-substitution System, we aim to improve the fidelity of electron microscopy for basic biomedical research. Although electron microscopy provides the most detailed images of cellular and t Health and Human Services, Department of / National Institutes of Health 4/01/2010
CORNELL UNIVERSITY, INC $43,043 Grant Trans-NIH Recovery Act Research Support: The need for affordable, healthy foods (including organic and locally produced items) has increased public interest in home, school and community gardens. In addition to food security, economic savings, and reduced environmental impacts associated with fo Health and Human Services, Department of / National Institutes of Health 5/21/2010
VALLEY FEVER SOLUTIONS, INC. $2,999,834 Grant Trans-NIH Recovery Act Research Support: 'Nikkomycin Z treatment of early coccidioidal pneumonia: Phase II clinical trial.' This project will further the development of a new, potentially curative drug, nikkomycin Z, to treat the fungal infection, Valley Fever (coccidioidomycosis). Health and Human Services, Department of / National Institutes of Health 5/08/2010
VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY $174,624 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Toll-like-receptor (TLR) mediated innate immunity signaling regulates various aspects of inflammation processes. Activations of TLRs lead to diverse gene expressions mediated by various transcription factors including Health and Human Services, Department of / National Institutes of Health 6/28/2010
NORTH CAROLINA STATE UNIVERSITY $540,474 Grant Trans-NIH Recovery Act Research Support: The worldwide funding devoted to nanotechnology research and development is expected to exceed $1 trillion by 2015. Carbon nanotubes are considered one of the most promising materials in nanotechnology and have numerous applications in medicine, industry Health and Human Services, Department of / National Institutes of Health 9/27/2009
MEDICAL UNIVERSITY OF SOUTH CAROLINA $53,888 Grant Trans-NIH Recovery Act Research Support: Specific Aim 1: To test the hypothesis that angiotensin-(2-10) is a bioactive peptide that modulates the in vivo actions of angiotensin-II on renal hemodynamics and tubular handling of sodium under physiological and pathological conditions. Research Desig Health and Human Services, Department of / National Institutes of Health 4/01/2010
THE INSTITUTE FOR CANCER RESEARCH $503,770 Grant Trans-NIH Recovery Act Research Support: Title: Characterization of Type-2 Cytokine-Producing NK Cells Abstract: Allergic immune responses are biased toward the production of type-2 cytokines. We have identified new surface markers of a small subset of human natural killer (NK) cells that prod Health and Human Services, Department of / National Institutes of Health 6/04/2009
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE $240,245 Grant Trans-NIH Recovery Act Research Support: Some 30-40 million people are living with Human immunodeficiency virus, HIV. Other retroviruses account for many more infections, and emerging infectious diseases are on the rise. Unfortunately, antiretroviral resistance develops in the presence of the se Health and Human Services, Department of / National Institutes of Health 5/12/2010
KANSAS STATE UNIVERSITY $92,500 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Leishmaniasis, a multi-spectrum disease transmitted by sand fly vectors, has an important social-economic impact in many countries. A strong relationship exists between sand flies and Leishmania such that, in nature, o Health and Human Services, Department of / National Institutes of Health 4/26/2010
CORNELL UNIVERSITY, INC $177,624 Grant Trans-NIH Recovery Act Research Support: Human rhinoviruses (HRV) are the major causative agent of the common cold and the most common acute infectious illness in humans. Due to the large number of HRV serotypes, little immunological protection is offered by prior rhinovirus exposure, rendering Health and Human Services, Department of / National Institutes of Health 5/03/2010
YALE UNIVERSITY $487,929 Grant Trans-NIH Recovery Act Research Support: Infectious diseases caused by pathogenic bacteria and viruses pose a serious challenge to global health. Each year approx 2.9 million people die from AIDS, approx 2 million from tuberculosis and 2 million from bacterially caused diarrhea. Emerging infecti Health and Human Services, Department of / National Institutes of Health 5/13/2010
OREGON STATE UNIVERSITY $207,580 Grant Trans-NIH Recovery Act Research Support: Infections by antibiotic resistant bacteria and the potential for sepsis are a major health concern. Antimicrobial peptides (AMPs) like cathelicidins (CAMP) and defensins are generating considerable interest for therapeutic use as potential bactericidals, Health and Human Services, Department of / National Institutes of Health 6/28/2010
EMORY UNIVERSITY $850,335 Grant Trans-NIH Recovery Act Research Support: Either total body exposure to ionizing radiation or inhalation of radioactive particulates can result in significant radiation dose deposition to the lungs. While a number of side effects can be observed from this type of exposure, pulmonary fibrosis is Health and Human Services, Department of / National Institutes of Health 6/14/2010
JOHNS HOPKINS UNIVERSITY, THE $36,416 Grant Trans-NIH Recovery Act Research Support: The main impetus of the original (parent) grant, NSAM: Wave 4: HIV/STD Risk Trajectories is to gain a more comprehensive and developmental understanding of HIV/STD risk behaviors among a nationally representative sample of males, who range in age from 32 Health and Human Services, Department of / National Institutes of Health 5/06/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $121,908 Grant Trans-NIH Recovery Act Research Support: The parent grant to this administrative supplement proposal has focused on determining molecular details of the HIV-1 Tat transcription activation mechanism that might lead to new inhibition strategies. Our recent results provide evidence for a unexpected Health and Human Services, Department of / National Institutes of Health 5/10/2010
UNIVERSITY OF LOUISVILLE $9,831 Grant Trans-NIH Recovery Act Research Support: This is a supplement to my R21 grant. The purpose is to hire undergraduate students to assist with the research work. Health and Human Services, Department of / National Institutes of Health 5/01/2010
UNIVERSITY OF KENTUCKY $99,716 Grant Trans-NIH Recovery Act Research Support: Patients with chronic kidney disease (CKD) present with abnormalities in mineral and bone metabolism, which are associated with high morbidity and mortality. The most relevant bone abnormalities encompass suppressed or extremely elevated bone turnover and Health and Human Services, Department of / National Institutes of Health 4/09/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $227,500 Grant Trans-NIH Recovery Act Research Support: Clinical and translational science is a major focus for the University of Pennsylvania (Penn) and Children's' Hospital of Philadelphia (CHOP). Indeed, the Penn/CHOP CTSA has catalyzed major institutional investments in translational research through the I Health and Human Services, Department of / National Institutes of Health 4/22/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $179,231 Grant Trans-NIH Recovery Act Research Support: The capacity of lipid molecules in cell membranes to separate into multiple liquid phases, forming so- called lipid rafts, has in the past decade been identified as an important physiological process. Lipid rafts are a control element in the cell membrane Health and Human Services, Department of / National Institutes of Health 4/29/2009
CHILDREN'S RESEARCH INSTITUTE $70,520 Grant Trans-NIH Recovery Act Research Support: The focus of the summer training is on molecular biochemistry and molecular genetics related to the studies proposed in the original R01. Technologies to be taught include genotyping, cell culture, cell transfection, expression profiling using microarray Health and Human Services, Department of / National Institutes of Health 5/19/2010
UNIVERSITY OF UTAH, THE $119,760 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Diabetic neuropathy, once well established, is poorly reversible in human trials. Sensitive diagnostic measures are necessary to identify patients with very early axonal injury who may be better candidates for interven Health and Human Services, Department of / National Institutes of Health 5/03/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $167,823 Grant Trans-NIH Recovery Act Research Support: Investigation of Intracellular Metabolism through Extracellular Flux Analysis The application supports the purchase of a Seahorse XF24-3 Extracellular Flux Analyzer that will enable real-time high throughput measurement of intracellular metabolism, which Health and Human Services, Department of / National Institutes of Health 5/13/2010
TRUSTEES OF INDIANA UNIVERSITY $74,883 Grant Trans-NIH Recovery Act Research Support: The George M. OG??Brien Center grant has as its primary goal the development of new optical methodologies for investigators in Neurologic and Urologic research. Many of these investigators require intravital multiphoton microscopy, 3-dimensional imaging Health and Human Services, Department of / National Institutes of Health 6/21/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $30,000 Grant Trans-NIH Recovery Act Research Support: Accurate segregation of duplicated chromosomes ensures that daughter cells get one and only one copy of each chromosome. Errors in chromosome segregation result in aneuploidy and have severe consequences on human health. Incorrect chromosome number and ch Health and Human Services, Department of / National Institutes of Health 5/26/2010
NEW YORK MEDICAL COLLEGE $500,000 Grant Trans-NIH Recovery Act Research Support: The broad, long term objective of this application is to provide investigators at New York Medical College with a FACSAria II high-speed cell sorter to advance studies in important research areas including diabetes, Lyme disease, renal disease, pulmonary Health and Human Services, Department of / National Institutes of Health 2/20/2010
INSILICOMED, INC. $200,000 Grant Trans-NIH Recovery Act Research Support: Cardiac resynchronization therapy (CRT) is currently used extensively for treatment of congestive heart failure patients with underlying electrical conduction defects. Up to 30% of patients receiving CRT do not respond to the therapy for unknown reasons. Health and Human Services, Department of / National Institutes of Health 4/29/2010
THE VANDERBILT UNIVERSITY $201,388 Grant Trans-NIH Recovery Act Research Support: An accurate assessment of human anatomy and physiology is critical to the success of clinical research. Echocardiography and vascular Doppler are assessment tools used in clinical research to evaluate the baseline characteristics of subjectsG?? physiology Health and Human Services, Department of / National Institutes of Health 3/25/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $115,315 Grant Trans-NIH Recovery Act Research Support: DNA glycosylases, ROS1 and DME, demethylate DNA via the base excision DNA repair pathway in Arabidopsis The purpose of the research is to elucidate how disease resistance is regulated by DNA demethylation. Previously, we showed that ROS1 is required for r Health and Human Services, Department of / National Institutes of Health 4/30/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $494,098 Grant Trans-NIH Recovery Act Research Support: Implementation of a Vaginal/Rectal HIV transmission model to evaluate microbicides. The hypothesis for this ARRA funded project is that the molecular basis of HIV resistance are multifactorial and can be studied in vivo using humanized mice reconstituted Health and Human Services, Department of / National Institutes of Health 5/17/2010
CASE WESTERN RESERVE UNIVERSITY $79,494 Grant Trans-NIH Recovery Act Research Support: The incidence of type 2 diabetes mellitus is rising, and therefore, so are the urological complications experienced by patients with type 2 diabetes. To increase our understanding of urological complications of diabetes, the principal investigator and his Health and Human Services, Department of / National Institutes of Health 9/15/2009
NET ESOLUTIONS CORPORATION $275,000 Contract : Provide the National Institutes of Health (NIH), Office of the Director (OD), Office of Science Policy and Analysis (OSPA) with the execution of NIH grant support implementation of the required NIH oversight related to the American Recovery and Reinvestme Health and Human Services, Department of / National Institutes of Health 11/24/2009
RFCUNY - BROOKLYN COLLEGE $619,001 Grant Trans-NIH Recovery Act Research Support: Elucidatiion of the biosynthesis of mycobacterial siderophores in M. tuberculosis to better understand the biology of the pathogen. Multidrug-resistant tuberculosis is recognized as an emerging infectious disease and a major problem in global public healt Health and Human Services, Department of / National Institutes of Health 5/05/2010
CENTRAL MICHIGAN UNIVERSITY (INC) $67,920 Grant Trans-NIH Recovery Act Research Support: Project Summary This research serves to evaluate the methodology and technology for measuring health information competencies (beliefs, skills, and knowledge) pertaining to finding and evaluating health resources from new digital media. This proposal serv Health and Human Services, Department of / National Institutes of Health 6/04/2010
SOCIAL & SCIENTIFIC SYSTEMS, INC. $6,000,000 Contract : Study of Environment, Lifestyle and Fibroids (SELF) - SELF is a longitudinal cohort study investigating the incidence and growth of uterine fibroids in a cohort of African American women, ages 23-34. SSS will develop study materials, provide IRB support, Health and Human Services, Department of / National Institutes of Health 4/13/2010
UNIVERSITY OF MASSACHUSETTS $77,781 Grant Trans-NIH Recovery Act Research Support: The mitotic repsonse to DNA damage. DNA damage disrupts mitotic chromosome segregation through a poorly defined process termed mitotic catastrophe. During early Drosophila embryogensis, this processi is linked to Chk2 kinase dependent centrosome inactiv Health and Human Services, Department of / National Institutes of Health 3/24/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $386,250 Grant Trans-NIH Recovery Act Research Support: The overall hypothesis tested in this proposal is the inflammatory responses in asthma are regulated by the cyclic nucleotide signaling pathway. We have demonstrated that enzymes that degrade inactivate cyclic nucleotides within a cell play a critical fun Health and Human Services, Department of / National Institutes of Health 6/21/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $38,240 Grant Trans-NIH Recovery Act Research Support: Francisella tularensis Pathogenesis (ARRA) Health and Human Services, Department of / National Institutes of Health 6/14/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $101,087 Grant Trans-NIH Recovery Act Research Support: The cellular responses activated by TGF beta family signaling underlie many developmental and proliferative events, including mesoderm induction, dorsalization and anti proliferative responses in mammalian cells. TGIF is a transcriptional repressor which Health and Human Services, Department of / National Institutes of Health 6/24/2010
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE $75,000 Grant Trans-NIH Recovery Act Research Support: Pain begins with transduction at peripheral nerve terminals of specialized sensory neurons called nociceptors. Understanding how these nociceptors respond to pain-producing stimuli is a key step towards understanding the biology of pain. This research con Health and Human Services, Department of / National Institutes of Health 6/20/2010
UNIVERSITY OF CINCINNATI $73,337 Grant Trans-NIH Recovery Act Research Support: The existing methods to treat posterior eye diseases are intravitreal and periocular injections or systemic drug administration. Posterior eye diseases such as posterior uveitis, endophthalmitis, and age-related macular degeneration affect more than a mil Health and Human Services, Department of / National Institutes of Health 7/01/2010
GOVERNORS STATE UNIVERSITY $442,011 Grant Trans-NIH Recovery Act Research Support: The objective of this proposal is to examine outcomes of a treatment intervention designed to increase functional use of complex (multi-clausal) sentences in school-age students with primary language impairments that impact literacy and academic achieveme Health and Human Services, Department of / National Institutes of Health 6/09/2010
UNIVERSITY OF TEXAS M D ANDERSON $1,051,688 Contract : UT-MD Anderson Cancer Center has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of clear cell renal cancer specimens (300 cases). These cases are all Health and Human Services, Department of / National Institutes of Health 4/28/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $28,674 Grant Trans-NIH Recovery Act Research Support: An enzyme that modifies sialic acid moieties known as Sialic acid acetyl esterase regulates the strength of signaling from the antigen receptor on B lymphocytes. Mutation of this gene in mice leads to enhanced B cell receptor signaling and autoimmunity - Health and Human Services, Department of / National Institutes of Health 5/24/2010
UNIVERSITY OF MASSACHUSETTS $82,365 Grant Trans-NIH Recovery Act Research Support: In the parent DIORAMA project we are developing a real-time scalable decision support framework built on RFID technology to enable an offsite commander to analyze the location and condition of the casualties in a disaster site. The primary goal of this su Health and Human Services, Department of / National Institutes of Health 5/25/2010
DUKE UNIVERSITY $47,070 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Gene expression patterns determine cell identity and are therefore essential for proper development and prevention of inappropriate cell proliferation. Expression patterns are determined by transcriptional activation a Health and Human Services, Department of / National Institutes of Health 6/25/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $500,000 Grant Trans-NIH Recovery Act Research Support: The aim of this project is to both improve and expand the imaging capabilities of the Axiom lab C-arm CT system by upgrading to the Siemens Artis zeego, a robot-mounted digital flat panel C-arm. The equipment will be shared by 15 users. A total of 13 NIH Health and Human Services, Department of / National Institutes of Health 6/10/2010
PAIGE INDUSTRIAL SERVICES, INC. $2,005,273 Contract : Recovery: East Bldg Face Fin Tube System Replacement-ARRA- Bldg 10 Health and Human Services, Department of / National Institutes of Health 3/02/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $169,634 Grant Trans-NIH Recovery Act Research Support: An estimated two billion people worldwide are infected with soil transmitted helminth parasites. Although there is strong evidence that T helper type 2 (Th2) cytokines are critical for immunity to infection, the early events that promote protective Th2 c Health and Human Services, Department of / National Institutes of Health 4/19/2010
SOUTHERN ILLINOIS UNIVERSITY $436,500 Grant Trans-NIH Recovery Act Research Support: CLCA2 is a mammary epithelial cell surface protein that is induced in response to contact inhibition and cellular stress. Its expression is downregulated in breast tumors, most dramatically in invasive and metastatic tumors and cell lines. Restored expres Health and Human Services, Department of / National Institutes of Health 6/21/2010
RESEARCH FOUNDATION FOR MENTAL HYGIENE INC $210,192 Contract : Enhancing Sample Retention in the Follow-Up of the Multimodal Treatment Study of Children with Attention Deficit Hyperactivity Disorder (MTA) Specific Tasks Sample Retention -Increase recruitment compensation -Add additional research support -Produce rec Health and Human Services, Department of / National Institutes of Health 4/23/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $519,068 Grant Trans-NIH Recovery Act Research Support: Our project entitled ?Role of TBK1 (Serine/threonine-protein kinase TANK-binding kinase 1) polyubiquitination in innate antiviral immunity? (1R56AI089829) analyzes TBK1 polyubiquitination (pUb) including characterization of the E3 ligases and identificati Health and Human Services, Department of / National Institutes of Health 6/28/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $498,500 Grant Trans-NIH Recovery Act Research Support: This award enabled us to acquire a state-of-the-art 3-D conformal irradiator for small animals. This means that we will are now able to irradiate tumors and normal tissue in animals with vconditions very similar to those used for human radiation therapy. Health and Human Services, Department of / National Institutes of Health 6/10/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $996,088 Grant Trans-NIH Recovery Act Research Support: UCLA-DREW/CITY OF LOS ANGELES AREA AGENCY ON AGING CENTER FOR COMMUNITY RESEARCH For the past 10 years, our UCLA-Drew scientists have worked in partnership with the leadership at the City of Los Angeles Department of Aging on community-based projects ai Health and Human Services, Department of / National Institutes of Health 6/10/2010
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC $9,963,289 Grant Trans-NIH Recovery Act Research Support: The purpose of this award is to renovate infrastructure serving an existing 5,000 square foot central data center to provide a new Core Research Computing Facility (CRCF) that will consolidate computational resources and improve data storage options for o Health and Human Services, Department of / National Institutes of Health 4/15/2010
CHILDRENS HOSPITAL OF PHILADELPHIA $14,926 Grant Trans-NIH Recovery Act Research Support: Cornelia de Lange syndrome (CdLS) is an autosomal dominant disorder of multiple congenital anomalies including characteristic facial features, upper extremity reduction defects, gastroesophageal dysfunction, growth retardation, and neurodevelopmental dela Health and Human Services, Department of / National Institutes of Health 4/09/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $276,422 Grant Trans-NIH Recovery Act Research Support: In order to further the specific aims of our parent grant, this supplement proposes to hire an additional Post-doctoral Research Associate to more rapidly determine the role plasmacytoid dendritic cells play in the translation of viral to atopic airway di Health and Human Services, Department of / National Institutes of Health 8/12/2009
YALE UNIVERSITY $30,942 Grant Trans-NIH Recovery Act Research Support: Human African trypanosomiasis (HAT) kills thousands of people each year in sub-Saharan Africa. The disease is caused by African trypanosomes transmitted by the tsetse fly.HAT transmission is complex; it requires mammalian and invertebrate hosts and involv Health and Human Services, Department of / National Institutes of Health 5/24/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $334,987 Grant Trans-NIH Recovery Act Research Support: The Laboratory for Drug Discovery for Neurodegeneration (LDDN) is a center that collaborates with laboratories from around the country for high throughput screening and medicinal chemistry projects for drug discovery with a focus on neurodegenerative dise Health and Human Services, Department of / National Institutes of Health 5/13/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $39,620 Grant Trans-NIH Recovery Act Research Support: The overall goal of the parent grant is to develop accurate methods for computing noncovalent binding affinities and thereby speed the discovery of new medications and targeted molecules for other biomedical applications.-? This Administrative Supplement Health and Human Services, Department of / National Institutes of Health 6/18/2010
UNIVERSITY OF TEXAS AT AUSTIN $446,311 Grant Trans-NIH Recovery Act Research Support: The primary goal of the research proposed in this competitive renewal application is to understand the role of Akt downstream signaling pathways in epithelial carcinogenesis. During the previous funding period, we discovered that Akt activation is an impo Health and Human Services, Department of / National Institutes of Health 5/18/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $50,000 Grant Trans-NIH Recovery Act Research Support: The overall goal of this supplement and the parent award is to understand how cells cooperate when they share secreted products. Saccharomyces cerevisiae cells secrete acid phosphatase to break down unimportable organic phosphates and secrete invertase to Health and Human Services, Department of / National Institutes of Health 4/09/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $340,470 Grant Trans-NIH Recovery Act Research Support: The overall aim of this study is to determine the phenotype, function, and role of CD4+CD25+ regulatory T cells (Treg cells) in HIV infected and uninfected humans. Health and Human Services, Department of / National Institutes of Health 4/05/2010
SCRIPPS RESEARCH INSTITUTE, THE $215,000 Grant Trans-NIH Recovery Act Research Support: Source MdX has built an integrated molecular medicine tracking system, called TheraTrax?, to provide high-precision tracking of disease and response to therapy. The Source TheraTrax? system is based on high-precision measurements of gene expression, a gro Health and Human Services, Department of / National Institutes of Health 6/10/2010
BOISE STATE UNIVERSITY $404,386 Grant Trans-NIH Recovery Act Research Support: Incomplete liver regeneration is an obstacle to recovery from liver disease and for patients who receive grafts through living-donor liver transplantation. Improved understanding of the mechanisms that regulate liver regeneration will facilitate the devel Health and Human Services, Department of / National Institutes of Health 4/12/2010
BAYLOR COLLEGE OF MEDICINE $96,118 Grant Trans-NIH Recovery Act Research Support: This administrative Support requests funding to replace old equipment needed for all projects of P01 AI 57788. This replacement equipment will enhance progress in research on human noroviruses by providing state of the art systems to quantitate virus loa Health and Human Services, Department of / National Institutes of Health 4/19/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $254,235 Grant Trans-NIH Recovery Act Research Support: The major goal of this proposal is to validate measurements of glycated CD59 (the glucose inactivated form of the key complement regulatory protein known as CD59) in human urine, as 1) a biomarker and predictor of vascular diabetic complications, 2) a pat Health and Human Services, Department of / National Institutes of Health 5/31/2010
UNIVERSITY OF CALIFORNIA, DAVIS $500,000 Grant Trans-NIH Recovery Act Research Support: The goal of this proposal is to secure funding to add a new small animal Positron Emission Tomography (PET) in vivo imaging system to the Center for Molecular and Genomic Imaging (CMGI). CMGI is a core facility at UC Davis that provides the infrastructure Health and Human Services, Department of / National Institutes of Health 4/08/2010
I2S MICRO IMPLANTABLE SYSTEMS, LLC $117,700 Contract : goods sold to nih Health and Human Services, Department of / National Institutes of Health 1/08/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $196,882 Grant Trans-NIH Recovery Act Research Support: The realization that HIV-1 eradication is impossible with current treatment raises two fundamental questions about HIV pathogenesis: how and where does the virus sustain itself as a life-long persistent infection? Our preliminary data suggest lymphoid tis Health and Human Services, Department of / National Institutes of Health 6/14/2010
UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) $9,621 Grant Trans-NIH Recovery Act Research Support: This grant provided a summer research experience for Kyell Schwartz, an undergraduate student from Rutgers University in health-related scientific research. In addition, following the summer, the project was continued with a no-cost extension until Decemb Health and Human Services, Department of / National Institutes of Health 6/21/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $558,162 Grant Trans-NIH Recovery Act Research Support: Characterizing unique virus-host interactions is key to understanding pathogenesis and developing therapeutics to block the virus life cycle. Because of their intimate associations with host cells, viruses have also been exploited as tools for studying m Health and Human Services, Department of / National Institutes of Health 7/17/2009
UNIVERSITY OF PITTSBURGH THE $108,000 Grant Trans-NIH Recovery Act Research Support: The overarching goal of the parent K23 award is to develop and pilot test a complex behavioral intervention to improve surrogate decision making for critically ill elders. The ARRA supplement award allows us to hire a study interventionist with a broader Health and Human Services, Department of / National Institutes of Health 4/12/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $3,453,917 Grant Trans-NIH Recovery Act Research Support: This G20 application proposes to renovate, repair and redesign core research laboratories at the University of Minnesota. The two main outcomes will be highly beneficial to NIH funded faculty researchers: 1) enable the juxtaposition of newly renovated, hi Health and Human Services, Department of / National Institutes of Health 3/31/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $499,867 Grant Trans-NIH Recovery Act Research Support: Confocal microscopy and live cell imaging capabilities have facilitated the adoption of optical sectioning methods as a primary tool for use in biomedical research. Expansion of the School of Dental Medicines (SDM) Imaging and Analytical core (IAC) thro Health and Human Services, Department of / National Institutes of Health 5/27/2010
UNIVERSITY OF CONNECTICUT $242,167 Grant Trans-NIH Recovery Act Research Support: Borrelia burgdorferi (Bb), the Lyme disease (LD) spirochete, is maintained in nature via an enzootic cycle which typically involves wild rodents and Ixodes ticks. During the current funding interval, we have used an expanding armamentarium of model system Health and Human Services, Department of / National Institutes of Health 6/07/2010
BECTON, DICKINSON AND COMPANY $5,795 Contract : Purchase of: Service Contract for FACSAria 3 Laser System Health and Human Services, Department of / National Institutes of Health 12/10/2009
UNIVERSITY OF ALABAMA AT BIRMINGHAM $219,750 Grant Trans-NIH Recovery Act Research Support: Growth hormone (GH) regulates postnatal growth and metabolism in humans and other vertebrates. GH signaling begins with its interaction with cell surface GH receptor (GHR), a transmembrane glycoprotein cytokine receptor family member. GHR encodes no int Health and Human Services, Department of / National Institutes of Health 4/12/2010
WASHINGTON UNIVERSITY, THE $54,000 Grant Trans-NIH Recovery Act Research Support: Postoperative morbidity and mortality is an under-recognized, yet significant public health problem. In 2004. 1.4% of all inpatients died after surgery. Myocardial infarction is a major contributor to postoperative mortality. Perioperative (pharmaco-)gene Health and Human Services, Department of / National Institutes of Health 4/05/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON $999,983 Grant Trans-NIH Recovery Act Research Support: Transplantation of hematopoietic stem cells (HSCs) derived from high-quality sources of tissue-matched bone marrow, mobilized peripheral blood or umbilical cord blood represents the therapeutic option of choice for the treatment of hematological malignanc Health and Human Services, Department of / National Institutes of Health 4/08/2010
MOUNT SINAI SCHOOL OF MEDICINE $324,871 Grant Trans-NIH Recovery Act Research Support: The serotonin type 1B (5-HT1B) receptor has been implicated in the pathogenesis of major depressive disorder (MDD). Highest concentrations of 5-HT1B receptors are found in the globus pallidus in humans. The globus pallidus has received attention recently Health and Human Services, Department of / National Institutes of Health 5/26/2010
UNIVERSITY OF ARIZONA $916,045 Grant Trans-NIH Recovery Act Research Support: Funds are requested for a LTQ Orbitrap XL ETDTM hybrid FT mass spectrometer, from Thermo Scientific to be used in research important in national defense, vaccine development, and for understanding chemical toxicity, kinase signaling, and pathogenicity of Health and Human Services, Department of / National Institutes of Health 5/13/2010
UNIVERSITY OF TEXAS AT EL PASO $419,147 Grant Trans-NIH Recovery Act Research Support: The need for culturally and Linguistically effective interventions for improved cancer pain management is critical in areas along the US-Mexico border where Hispanics of Mexican-American origin exceed 78% of the population. Emerging evidence suggests that Health and Human Services, Department of / National Institutes of Health 6/01/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $153,202 Grant Trans-NIH Recovery Act Research Support: Recent evidence indicates the importance of the innate immune system in both graft rejection and the induction of tolerance in solid organ transplantation. However, the specific cell types and molecules of the innate immune system involved in these proces Health and Human Services, Department of / National Institutes of Health 6/21/2010