Primary Recipient

CHILDREN'S RESEARCH INSTITUTE

Amount

$558,800.00

Award Date

9/15/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

The goal of this project is to produce a murine model for neonatal onset N-acetyl-L-glutamate synthase (NAGS) deficiency by creating a mouse in which the NAGS gene has been disrupted. Defects in urea cycle genes such as NAGS affect approximately one in 16