Primary Recipient

SEATTLE CHILDREN'S HOSPITAL

Amount

$48,527.00

Award Date

9/11/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

FOXP3 Structure, Function and Regulatory Activity in T cells -- The transcription factor FOXP3 is required for development of functional CD4+CD25+ regulatory T cells (Treg). Mutations in FOXP3 lead to a severe systemic autoimmune phenotype in both huma