Primary Recipient

MEDICAL UNIVERSITY OF SOUTH CAROLINA

Amount

$405,580.00

Award Date

8/11/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

The Rev-RRE interaction and the subsequent transport of intron-containing viral mRNA mediated by the cellular export receptor CRM1 are essential to the replication of the HIV-1 retrovirus. The current model for oligomeric Rev binding to its cognate RRE is