Primary Recipient

TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Amount

$533,649.00

Award Date

9/28/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

Gamma-secretase inhibitors (GSIs), which block the presenilin-gamma secretase complex, inhibit the production of amyloidogenic A? beta peptides involved in the pathogenesis of Alzheimer?s disease and the activation of NOTCH receptors. Recent identificatio