Primary Recipient

UNIVERSITY OF CHICAGO, THE

Amount

$780,000.00

Award Date

7/21/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

Evidence suggests that one mechanism of peripheral immunologic tolerance occurs through the process of T cell anergy. Anergic T cells have been characterized to have a defect in TCR/CD28-mediated Ras activation. Recent data have indicated that upregulated