Recovery Tracker

How Much Stimulus Funding is Going to Your County?

New Haven County, Conn., funds by Health and Human Services, Department of

Listing $173,950,618.67 in stimulus funds from Health and Human Services, Department of for New Haven

Note: For some programs where states do not report where money will be distributed across the state, we do not have the allocation for individual counties. Those programs include: Medicaid, unemployment benefits and food stamps. Those amounts are included in the totals for where the state agency receiving that money is located.

Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.

Recipient Amount Description Federal Dept./Agency Date
SOCIAL SERVICES, CONNECTICUT DEPARTMENT OF $13,685,624 ARRA Child Care and Development Block Grant ARRA Supplemental Funding for Child Care and Development Fund (CCDF) - Provides child care financial assistance to low-income working families and fund activities to improve the quality of child care. The Project Description field will provide space to el Administration for Children and Families 4/09/2009
YALE UNIVERSITY $9,889,558 Trans-NIH Recovery Act Research Support The main goal of the presently assembled Grand Opportunity consortium is to conduct a spatiotemporally comprehensive survey of the human brain transcriptome and create a unique multimodal atlas encompassing all pre- and postnatal developmental stages, inc National Institutes of Health 9/30/2009
YALE UNIVERSITY $9,197,360 Trans-NIH Recovery Act Research Support This application requests funding to renovate the animal facility in a newly acquired Yale research complex that was purchased from Bayer in 2007. The animal facility was used by Bayer for a combination of large animal and rodent studies and has been vaca National Institutes of Health 9/23/2010
YALE UNIVERSITY $3,601,665 Trans-NIH Recovery Act Research Support Genomewide association study of cocaine dependence in two populations Abstract: Cocaine dependence (CD) is highly costly to society; genetic epidemiologic studies support moderate heritability for this trait. We have completed a genomewide linkage study
This spending item is part of a $4,207,355 allocation. See details
National Institutes of Health 9/30/2009
YALE UNIVERSITY $3,545,763 Trans-NIH Recovery Act Research Support On behalf of the Reproductive Medicine Network (RMN), we, as the Data Coordination Center, submit this request in response to NIH announcement NOT-OD-09-056 for a Recovery Act administrative supplement. We will use the supplement to field a comparative ef
This spending item is part of a $7,565,277 allocation. See details
National Institutes of Health 9/30/2009
YALE UNIVERSITY $3,308,170 Trans-NIH Recovery Act Research Support The genetic variability and Individual variations in immune status dictate responses to vaccinations, infections, and contribute to disease severity. The sequencing of the human genome and generation of the Haplotype Map now enables a mechanistic understa
This spending item is part of a $4,456,091 allocation. See details
National Institutes of Health 7/12/2010
YALE UNIVERSITY $3,242,514 Trans-NIH Recovery Act Research Support As life expectancy in the United States continues to rise, the maintenance of physical independence among older Americans has emerged as a major clinical and public health priority. Efficient and reliable locomotion, or the ability to move without assista
This spending item is part of a $29,648,216 allocation. See details
National Institutes of Health 9/24/2009
AXERION THERAPEUTICS, INC. $3,000,000 Trans-NIH Recovery Act Research Support Axerion seeks to develop therapeutic agents to promote the recovery of neurological function through axonal fiber growth and enhanced plasticity after brain or spinal cord damage. In nearly all neurological conditions, a substantial portion of brain and s National Institutes of Health 4/19/2010
AXERION THERAPEUTICS, INC. $3,000,000 Trans-NIH Recovery Act Research Support Axonal Growth Therapy for neurological Recovery from Spinal Cord Injury and Stroke National Institutes of Health 4/19/2010
YALE UNIVERSITY $2,906,138 Trans-NIH Recovery Act Research Support We will apply whole exome sequencing to discover mutations causing structural brain disease in a large cohort of patients from consanguineous union. Comprehensive discovery of mutations that cause brain malformations holds great promise for advancing unde National Institutes of Health 9/25/2009
YALE UNIVERSITY $2,300,000 Trans-NIH Recovery Act Research Support The goal of this shared instrumentation proposal is to expand the capabilities of the Yale Positron Emission Tomography (PET) Center by the acquisition of a state-of-the-art PET/CT scanner for human research studies. PET imaging provides a non-invasive me National Institutes of Health 6/17/2010
YALE UNIVERSITY $2,245,836 Trans-NIH Recovery Act Research Support This proposal is in response to a request for applications to address ''''Genomic Profiling of Mental Disorders,'''' and proposes intensive genomic profiling and functional analysis of Contactin Associated Protein 2 (CNTNAP2) as well as the presynaptic cy National Institutes of Health 9/30/2009
GRIFFIN HOSPITAL INC, THE $2,142,063 ARRA Grants for Training in Primary Care Medicine and Dentistry Training and Enhancement Training Residents to Provide Patient-Centered Care to Underserved Patients : The purpose of this project is to support and further improve the Griffin Hospital General Internal Medicine Residency (GIMR) program... Show more Health Resources and Services Administration 9/03/2010
YALE UNIVERSITY $1,987,576 Trans-NIH Recovery Act Research Support A consistently replicated biological phenotype in autism spectrum disorders (ASD) is a larger head circumference (HC) in the first years of life. We hypothesize that increased brain size in ASD is attributable to altered dynamics of cell proliferation and National Institutes of Health 9/08/2009
NEW OPPORTUNITIES, INC. $1,604,847 ARRA - Community Services Block Grant ARRA Supplemental Funding for the Community Services Block Grant (CSBG) Program provides economic stimulus by advancing the economic and social well-being of low-income individuals and families of the state of Connecticut. With an award of $12,060,854, 9
This spending item is part of a $12,060,854 allocation. See details
Administration for Children and Families 4/10/2009
COMMUNITY ACTION AGENCY OF NEW HAVEN, INC. $1,538,789 ARRA - Community Services Block Grant ARRA Supplemental Funding for the Community Services Block Grant (CSBG) Program provides economic stimulus by advancing the economic and social well-being of low-income individuals and families of the state of Connecticut. With an award of $12,060,854, 9
This spending item is part of a $12,060,854 allocation. See details
Administration for Children and Families 4/10/2009
YALE UNIVERSITY $1,524,000 Trans-NIH Recovery Act Research Support The Yale Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR) was co-founded by the PI and Co-PI four years ago with the goal of linking basic research in neuronal cell biology with efforts to advance pathophysiological understanding of n National Institutes of Health 9/28/2009
GRIFFIN HOSPITAL INC, THE $1,424,450 ARRA - Preventive Medicine Residency Program Griffin Preventive Medicine Residency Program: The purpose of this project is to support and improve Griffin's PMR program by creating, implementing, and evaluating a needs-based innovative training curriculum in lifestyle medicine (LM), addiction/substan... Show more Health Resources and Services Administration 7/01/2010
YALE-NEW HAVEN HEALTH SERVICES CORPORATION $1,396,192 ARRA funding to support the development of risk adjusted outcomes measures based on clinical data abstracted from EHR systems employed by hospitals. Health Care Financing Admin. (was Medicare and Medicaid Serv.) 9/20/2010
YALE UNIVERSITY $1,345,812 Trans-NIH Recovery Act Research Support Obesity and obesity related medical conditions contribute to increased mortality among persons with schizophrenia and increased healthcare costs. There are no treatments that have been convincingly shown to be effective for weight reduction in this popula National Institutes of Health 4/28/2009
YALE UNIVERSITY $1,334,390 Trans-NIH Recovery Act Research Support This application, entitled 'The Role of Rare Variants in Multiple Sclerosis Risk', addresses Research and Research Infrastructure 'Grand Opportunities'. Many human autoimmune diseases, including multiple sclerosis (MS) are complex genetic disorders. MS is
This spending item is part of a $1,917,986 allocation. See details
National Institutes of Health 9/28/2009
YALE UNIVERSITY $1,301,177 Trans-NIH Recovery Act Research Support This is an efficacy study of an intensive home visitation intervention, Minding the Baby (MTB). This reflective parenting program (aimed at enhancing maternal reflective capacities), is focused on first-time young mothers and their infants living in an ur National Institutes of Health 9/29/2009
CORNELL SCOTT-HILL HEALTH CORPORATION $1,288,520 ARRA Health Center Integrated Services Development Initiative[g1] Purpose: To implement an IT (Information Technology) equipment-only project to purchase equipment and consulting services in order to create a state of the art IT system, IT infrastructure, and communications necessary for CS-HHC to i... Show more Health Resources and Services Administration 6/25/2009
YALE UNIVERSITY $1,234,230 Trans-NIH Recovery Act Research Support We will use fMRl to characterize the neural basis of development in social cogntion. Our understanding of the pathogenesis of psychiatric disorders that affect social cognition and social behavior (e.g., autism, anxiety disorders, anorexia, and schizophre National Institutes of Health 7/16/2009
YALE UNIVERSITY $1,172,590 Trans-NIH Recovery Act Research Support Treatment of breast cancer with hormonal therapy and more recently trastuzumab (Herceptin) has led the field of cancer treatment in the use of companion diagnostics to select patients most likely to respond to targeted therapies. However, the currently us National Institutes of Health 8/05/2009
YALE UNIVERSITY $1,153,026 Trans-NIH Recovery Act Research Support The goal of this application is to provide for support for recruitment of new tenure-track in the Section of Cardiovascular Medicine and Yale Cardiovascular research Center faculty from among the graduating fellows from accredited cardiology fellowship pr National Institutes of Health 9/30/2009
EMPOWER NEW HAVEN INC $1,000,000 ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program; The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-incom Administration for Children and Families 9/30/2009
YALE UNIVERSITY $1,000,000 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area 06: Enabling technologies and specific Challenge Topic Breakthrough technologies for neuroscience (06-NS-103). The title of this proposal is Genomewide screening of transmembrane accessory subunits of ion ch National Institutes of Health 9/25/2009
YALE UNIVERSITY $1,000,000 Trans-NIH Recovery Act Research Support Asthma is characterized by chronic airway inflammation. It is well established that Th2 inflammation and the downstream responses that occur provide much of the underlying basis of asthma pathogenesis. The biologic function of Th2 inflammation is believed National Institutes of Health 9/18/2009
YALE UNIVERSITY $999,475 Trans-NIH Recovery Act Research Support We described rickets in children in our inner city area (over 80% minorities) with either low or normal circulating 25-hydroxyvitamin D (25-OHD) levels, and have found that vitamin D deficiency (circulating 25-OHD less than 20 ng/ml) occurs in 13% of over National Institutes of Health 9/30/2009
YALE UNIVERSITY $998,276 Trans-NIH Recovery Act Research Support This application addresses the broad Challenge Area (03) Biomarker Discovery and Validation and specific Challenge topic, 03-MH-101: Biomarkers in Mental Disorders and is entitled: Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that C National Institutes of Health 9/28/2009
YALE UNIVERSITY $993,553 Trans-NIH Recovery Act Research Support Performance Indices of Social Disability in Toddlers with Autism' - addresses Challenge Area '(04) Clinical Research' and Specific Challenge Topic 'Autism: Addressing the Challenge (04-MH-101*)'; and Challenge Area '(01) Behavior, Behavioral Change, and P National Institutes of Health 9/29/2009
YALE UNIVERSITY $991,807 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (05), Comparative Effectiveness Research and Specific Challenge Topic, 05-MD-102, Prevention of Chronic Diseases in Disparity Populations. Building on our previous research in teens with type 1 diabetes (T1D National Institutes of Health 9/23/2009
YALE UNIVERSITY $991,054 Trans-NIH Recovery Act Research Support It is known that, in addition to genetic susceptibility in many diseases, environmental factors play a critical role in determining whether susceptible individuals develop the disease. However, it is not clear what these environmental factors are. The env National Institutes of Health 9/28/2009
YALE UNIVERSITY $985,031 Trans-NIH Recovery Act Research Support Our Broad Challenge is to develop enabling technologies for the prevention and treatment of diseases affecting the bladder. The Proof of Concept that we are testing is that intravesical instillation of small interference RNA (siRNA) packaged in biodegrada National Institutes of Health 9/23/2009
YALE UNIVERSITY $969,272 Trans-NIH Recovery Act Research Support It is the premise of this Challenge Grant that investigations of the dynamics of membrane structure and function would be tremendously facilitated by the development of robust methods for the manufacture of suspended bilayers that are surrounded on both s National Institutes of Health 9/30/2009
YALE UNIVERSITY $963,916 Trans-NIH Recovery Act Research Support The application addresses broad challenge area Model organisms for social behavior studies: Identification and development of model organisms that allow for integrative analyses of the genetic, biochemical, physiological, and environmental components of s National Institutes of Health 9/16/2010
YALE UNIVERSITY $963,898 Trans-NIH Recovery Act Research Support Neurological recovery is limited in many clinical situations by the inability of adult brain and spinal cord to grow axons and form new connections to replace lost function. This Project seeks to define the molecular limitations on nerve fiber growth in t National Institutes of Health 7/19/2009
YALE UNIVERSITY $946,752 Trans-NIH Recovery Act Research Support The use of fluorescent protein tags has revolutionized all aspects of cell biology research during the last 15 years, enabling analysis of the dynamic structures within living cells. The cloning of Green Fluorescent Protein (GFP) and the subsequent develo National Institutes of Health 9/25/2009
YALE UNIVERSITY $935,049 Trans-NIH Recovery Act Research Support Aberrant somitogenesis leads to birth defects in humans. Later in life abnormal Notch, Wnt or Fgf signaling causes malignancies such as colon cancer and leukemia. We use zebrafish as a tractable, relatively inexpensive vertebrate model system to study how National Institutes of Health 8/07/2009
YALE UNIVERSITY $931,206 Trans-NIH Recovery Act Research Support This proposal seeks to acquire a Zeiss LSM 710 Duo confocal/multiphoton fluorescence microscope for the Center for Cell and Molecular Imaging at Yale University School of Medicine. This microscope would replace the oldest of three confocal microscopes in National Institutes of Health 5/06/2010
YALE UNIVERSITY $928,143 Trans-NIH Recovery Act Research Support Inflammation is a process essential for host defense and tissue repair. However, exuberant defense may cause pathogenic changes leading to vascular diseases such as atherosclerosis. This is because multiple cytokines are involved in the process and each c
This spending item is part of a $1,050,843 allocation. See details
National Institutes of Health 8/31/2009
YALE UNIVERSITY $909,360 Trans-NIH Recovery Act Research Support The proposed experiments investigate signaling pathways linked to Slack potassium channels. Understanding these proteins will aid development of therapies for stroke, epilepsy and mental retardation. National Institutes of Health 9/07/2009
YALE UNIVERSITY $901,569 Trans-NIH Recovery Act Research Support Spatial mapping of human and animal brain function is crucial for the diagnosis of brain disorders, to follow the efficacy of therapy or intervention and to increase scientific knowledge. 17O NMR based mapping can become a fast and robust tool to assess a National Institutes of Health 4/30/2009
YALE UNIVERSITY $898,724 Trans-NIH Recovery Act Research Support This high-end instrument grant is to request funds for an iCyt Reflection Cell Sorter that will be dedicated for Biosafety Level 3 (BSL3) research at Yale University School of Medicine as a shared instrument amongst greater than 15 labs. In response to th National Institutes of Health 12/09/2009
STAYWELL HEALTH CARE, INC. $876,325 ARRA Health Center Integrated Services Development Initiative[g1] ARRA Capital Improvement Project Health Resources and Services Administration 6/25/2009
STAYWELL HEALTH CARE, INC. $876,325 ARRA - Capital Improvement Program Health Resources and Services Administration 6/25/2009
YALE UNIVERSITY $870,314 Trans-NIH Recovery Act Research Support BCL-xL is the major anti-cell death BCL-2 family member expressed in brain, and understanding its function is key to designing strategies for neuroprotection. In this application, we will attempt to prove that inhibition of BCL-xL or down regulation of ex National Institutes of Health 9/15/2009
YALE UNIVERSITY $854,129 Trans-NIH Recovery Act Research Support Our work in both rodents and primates has indicated that the biochemical and behavioral effects of withdrawal from repeated phencyclidine (PCP) form a useful model of the cognitive deficits of schizophrenia. PCP exposure imparts a lasting and regionally-s National Institutes of Health 9/23/2009
YALE UNIVERSITY $832,963 Trans-NIH Recovery Act Research Support The goal of this project is to test risk and resiliency pathways linking social determinants of health and child characteristics to young children's health. We will examine the role of four social determinants of health (i.e., social position, racism, seg
This spending item is part of a $1,035,964 allocation. See details
National Institutes of Health 9/30/2009
YALE UNIVERSITY $827,500 Trans-NIH Recovery Act Research Support Preeclampsia and intrauterine growth restriction are serious complications of pregnancy that endanger maternal and fetal health. Its most severe cases are associated with a fetal mortality of 50%. In this application we propose to study the mechanism of p National Institutes of Health 8/01/2009
YALE UNIVERSITY $827,500 Trans-NIH Recovery Act Research Support Understanding the effects of VEGF augmentation in the developing lung as a method of lung maturation, and defining the contributions of the Nitric Oxide pathway in this process, can pave the way for appropriate therapeutic interventions in the human disea National Institutes of Health 7/16/2009
YALE UNIVERSITY $826,221 Trans-NIH Recovery Act Research Support Mental and physical functioning have major implications for the quality of life of older individuals. We plan to examine a largely unexplored social psychological factor that may benefit older individuals longterm functioning: the age stereotypes that ind National Institutes of Health 7/21/2009
YALE UNIVERSITY $824,822 Trans-NIH Recovery Act Research Support Mice with a null mutation of the homeobox gene Hhex die mid-gestation with multiple developmental defects, including complete absence of the liver. Recently, we derived two strains of mice with a deletion of Hhex in the developing liver - at E9.0 in the l National Institutes of Health 9/23/2009
YALE UNIVERSITY $823,948 Trans-NIH Recovery Act Research Support Compelling evidence suggests that alteration of normal prenatal development influences one's lifetime risks for obesity and cardiovascular disorders, which are components of the 'metabolic syndrome. Reflecting the public health importance of elucidating National Institutes of Health 9/22/2009
YALE UNIVERSITY $821,933 Trans-NIH Recovery Act Research Support As the genetic knowledge of epilepsy grows, primary prevention will soon be a realistic goal. Detailed study of a genetic animal model in which epilepsy can be prevented will provide proof-of-principle information to guide human treatment trials. In addit National Institutes of Health 9/15/2009
YALE UNIVERSITY $820,950 Trans-NIH Recovery Act Research Support The treatment of P. aeruginosa infections is often difficult: these bacteria are highly resistant to most antibiotics and grow as biofilms that cannot be effectively eradicated by antimicrobials or the human immune response. Completion of these experiment National Institutes of Health 5/21/2009
YALE UNIVERSITY $818,140 Trans-NIH Recovery Act Research Support This country lacks a cohesive, informative surveillance system for vascular disease that can provide insights into national patterns of stroke and reveal national trends over time. Stroke is a major public health problem in the United States. It is the th
This spending item is part of a $960,956 allocation. See details
National Institutes of Health 9/25/2009
YALE UNIVERSITY $798,420 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic (15-MH-105) Strategies to Support Uptake of Interventions within Clinical Community and Settings. Implementation of evidence-based treatments into ment
This spending item is part of a $918,498 allocation. See details
National Institutes of Health 9/24/2009
YALE UNIVERSITY $781,907 Trans-NIH Recovery Act Research Support This proposal is based on the observation that ?-catenin protein is localized to the leading edge of migrating astrocytes. In preliminary work we have examined this increase and determined it to be dependent upon new protein synthesis. Since cadherin/cate National Institutes of Health 9/25/2009
YALE UNIVERSITY $774,560 Trans-NIH Recovery Act Research Support During natural visually guided behavior people are routinely exposed to a vast and potentially overwhelming amount of visual information. The human brain is simply unable to encode and respond to each and every image that enters the eyes. Visual attention National Institutes of Health 5/14/2009
YALE UNIVERSITY $767,793 Trans-NIH Recovery Act Research Support This application addresses the broad Challenge Area (08) Genomics, Beyond GWAS 08-DK-102. The overall genetic architecture and pathogenic mechanisms of complex disorders such as Crohn's disease (CD) is incompletely defined at present. Genome-wide associat
This spending item is part of a $998,477 allocation. See details
National Institutes of Health 9/29/2009
JOHN B. PIERCE LABORATORY, INC., THE $767,233 Trans-NIH Recovery Act Research Support 'High-speed, wide field fluorescent imaging of cortex in freely moving animals This project will produce a miniature microscope/imaging system which can be head mounted and will allow the recording of optical signals of changes in membrane voltage and ca
This spending item is part of a $1,189,290 allocation. See details
National Institutes of Health 7/20/2009
YALE UNIVERSITY $749,840 Trans-NIH Recovery Act Research Support The guiding question is whether early intervention can improve long term outcomes for psychotic disorders in the U.S. We hypothesize that a specialized multi-component intervention, delivered in a public mental health clinic will be more effective than us National Institutes of Health 9/23/2009
YALE UNIVERSITY $748,112 Trans-NIH Recovery Act Research Support The processes that cause destruction of beta cells that leads to Type 1 and Type 2 diabetes are silent. Their effects can only be appreciated after there has been considerable destruction of cells and the level of glucose rises. However for years before e National Institutes of Health 9/26/2009
FAIR HAVEN COMMUNITY HEALTH CLINIC INC $740,385 ARRA Health Center Integrated Services Development Initiative[g1] The CIP has been funded in two project areas: 1) Alterations and Renovations and 2)Purchase of a new C-Chit certified PMS/EHR. The implementation of the two projects will have an immediate and dramatic impact on our efficiency, quality... Show more Health Resources and Services Administration 6/25/2009
JOHN B. PIERCE LABORATORY, INC., THE $711,110 Trans-NIH Recovery Act Research Support How multimodal stimuli become integrated is a fundamental question in neuroscience. This question is particularly relevant to flavor perception, in which simultaneous stimulation of touch, temperature, taste and olfaction invariably occurs during ingestio National Institutes of Health 6/02/2009
YALE UNIVERSITY $701,688 Trans-NIH Recovery Act Research Support In this study, we propose to perform the first genome-wide association study (GWAS) for Immunoglobulin A Nephropathy (IgAN, OMIM %161950), an understudied disease that is a major cause of kidney failure in the U.S. and worldwide. It is the most common cau
This spending item is part of a $997,981 allocation. See details
National Institutes of Health 9/25/2009
YALE UNIVERSITY $698,903 Trans-NIH Recovery Act Research Support The majority of studies, including our own preliminary results, support the model that the cells that repair the kidney after acute injury are existing tubule epithelial cells. As proposed in the background and preliminary results, we believe that de-diff National Institutes of Health 9/29/2009
YALE UNIVERSITY $694,899 Trans-NIH Recovery Act Research Support The conduct of interdisciplinary and translational clinical research is complex and can be optimized through coordination of specialized resources across projects. This P30 will provide core Human Subjects resources for coordinated and efficient data coll National Institutes of Health 8/16/2010
YALE UNIVERSITY $668,570 Trans-NIH Recovery Act Research Support Aminoacyl-tRNAs provide the interface between genetic information encoded in the DNA sequence of a gene and the amino acid sequence of the corresponding protein. In this supplement three important aspects of aminoacyl-tRNA formation are addressed. (i) Usi National Institutes of Health 6/18/2009
YALE UNIVERSITY $668,244 Trans-NIH Recovery Act Research Support Studies of primary human B cell defects have led to an appreciation of specific stages of B cell development. Commitment to the B cell lineage occurs early in lymphogenesis with selected gene rearrangements in Ig heavy chain genes; these initiate the proc
This spending item is part of a $3,099,050 allocation. See details
National Institutes of Health 9/17/2009
YALE UNIVERSITY $661,921 Trans-NIH Recovery Act Research Support Proper functioning of the cell cycle and its regulation in response to both internal and external stimuli is essential for the normal growth, division, and differentiation of cells and tissues. One of the regulators of cell cycle progression is the Anapha National Institutes of Health 9/17/2009
YALE UNIVERSITY $645,588 Trans-NIH Recovery Act Research Support Twenty millions Americans suffer from chronic kidney disease, and are at significantly greater risk for having both fatal and non-fatal cardiovascular complications. The pathogenesis of cardiac disease in this patient population is not well understood. Pa National Institutes of Health 8/18/2009
YALE UNIVERSITY $635,962 Trans-NIH Recovery Act Research Support Allergic diseases such as contact sensitivity and delayed type hypersensitivity can be very debilitating and are a rapidly increasing and costly burden on public health systems in the United States. This proposal will develop new technology to facilitate National Institutes of Health 5/21/2009
YALE UNIVERSITY $631,892 Trans-NIH Recovery Act Research Support Salmonella enterica serovar Typhi (S. Typhi), the cause of typhoid fever in humans, continues to be a very significant health problem. It is estimated that there are 16,000,000 cases of typhoid fever every year, resulting in 600,000 deaths. Unlike other S National Institutes of Health 5/14/2009
YALE UNIVERSITY $618,142 Trans-NIH Recovery Act Research Support Metastasis of tumor cells to other tissues and organs is the leading cause of mortality from breast cancer. Metastatic breast cancer cells escape the tumor and enter the bloodstream by forming filamentous-actin-rich protrusions called invadopodia that dig National Institutes of Health 5/21/2009
YALE UNIVERSITY $595,636 Trans-NIH Recovery Act Research Support The purpose of this R21/R33 investigation is to satisfy the critical unmet norepinephrine transporter (NET) tracer need. The investigation will afford candidate NET Positron emission Tomography (PET) imaging agents with unique in vitro structure-activity
This spending item is part of a $1,123,728 allocation. See details
National Institutes of Health 7/21/2009
YALE UNIVERSITY $591,563 Trans-NIH Recovery Act Research Support Both projects (NET positron emission tomography imaging in alcohol dependence and obesity as well s cannabinoid receptor type 1 imaging in alcohol dependence) within this program have progressed nicely and important methodological progress has been made i
This spending item is part of a $788,664 allocation. See details
National Institutes of Health 6/22/2010
UNITED WAY OF GREATER NEW HAVEN INC $577,903 ARRA - Head Start UWGNH is providing full-day, full-year Early Head Start program services to 41 infants and toddlers through three delegates. Two delegates are providing center-based care; the third delegate is providing licensed family child care. All of the children a
This spending item is part of a $1,141,969 allocation. See details
Administration for Children and Families 12/17/2009
YALE UNIVERSITY $545,200 Trans-NIH Recovery Act Research Support North American AIDS Cohorts Collaboration on Research and Design A disturbing increase in the incidence of non-AIDS-defining conditions including renal disease, metabolic and cardiovascular disease, and malignancies has been observed in recent years, and
This spending item is part of a $7,312,062 allocation. See details
National Institutes of Health 9/21/2009
YALE UNIVERSITY $540,062 Trans-NIH Recovery Act Research Support Genetic architecture of alcohol misuse candidate endophenotypes - Research Area This application addresses broad Challenge Area 03) Biomarker Discovery and Validation; specific Challenge Topic 03-AA-101,Identification of Intermediate Phenotypic Markers o
This spending item is part of a $996,533 allocation. See details
National Institutes of Health 9/25/2009
YALE UNIVERSITY $529,918 Trans-NIH Recovery Act Research Support The proper function of axons, the output of neurons, is critical to the proper functioning of the brain, particularly the cerebral cortex. Numerous neurological disorders result from disruption of axonal function. Our study will use newly developed and st National Institutes of Health 9/15/2009
GRIFFIN HOSPITAL INC, THE $529,111 Trans-NIH Recovery Act Research Support Osteoarthritis (OA), the most common form of arthritis, is a slowly progressive degenerative disease of joint cartilage that afflicts 40 million Americans. Existing pharmacologic therapies (acetaminophen, non- steroidal anti-inflammatories (NSAIDs), & COX
This spending item is part of a $1,410,313 allocation. See details
National Institutes of Health 6/29/2009
YALE UNIVERSITY $522,184 Trans-NIH Recovery Act Research Support Tobacco use is mostly initiated during adolescence and we have few effective smoking cessation or prevention strategies for high school aged smokers. This project will develop and test an innovative high-school based intervention that will be designed to
This spending item is part of a $761,988 allocation. See details
National Institutes of Health 8/10/2009
YALE UNIVERSITY $502,332 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (04) Clinical Research, specific Challenge Topic 04-HL-104'Perform secondary analyses of existing data to answer important clinical and preventive medicine researchquestions.' We propose to use existing data
This spending item is part of a $998,292 allocation. See details
National Institutes of Health 9/23/2009
YALE UNIVERSITY $500,000 Trans-NIH Recovery Act Research Support The challenge area (03-DK-102) is the development and validation of novel, noninvasive methods to detect and monitor disorders of relevance to NIDDK at early stages of disease before major organ damage and dysfunction has occurred. Novel diagnostic method National Institutes of Health 4/08/2010
YALE UNIVERSITY $500,000 Trans-NIH Recovery Act Research Support Asthma is characterized by chronic airway inflammation. It is well established that Th2 inflammation and the downstream responses that occur provide much of the underlying basis of asthma pathogenesis. The biologic function of Th2 inflammation is believed National Institutes of Health 9/18/2009
YALE UNIVERSITY $500,000 Trans-NIH Recovery Act Research Support The challenge area (15-DK-103) is the translation of new molecules and pathways involved in pathogenesis of diseases of interest to NIDDK into potential therapies, diagnostics, or research tools. The specific challenge topic is the examination of the ther National Institutes of Health 3/29/2010
YALE UNIVERSITY $500,000 Trans-NIH Recovery Act Research Support Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of numerous cysts in affected kidneys that lead to renalfailure in about half of ADPKD patients. The disease burden from ADPKD in U.S. alone is estimated at 6 National Institutes of Health 4/01/2010
NEW HAVEN, CITY OF (INC) $499,314 ARRA - Head Start BHS Award Description: New Haven Board of Education Head Start provides comprehensive health, developmental and family services to 726 children and their families residing in the city of New Haven through a variety of program options including full day/fu Administration for Children and Families 7/29/2009
YALE UNIVERSITY $496,785 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Cell Biology is intimately linked with the ability to see organelles, vesicles, cytoskeleton and even single molecules inside cells, both in normal and diseased states. Instruments that allow biologists to see better, National Institutes of Health 6/10/2010
YALE UNIVERSITY $496,500 Trans-NIH Recovery Act Research Support These studies will allow us to better understand the molecular basis for individual differences in the response to progesterone in cocaine dependent men and women. Better understanding of these differences will allow us to identify those individuals (both National Institutes of Health 9/15/2009
YALE UNIVERSITY $491,747 Trans-NIH Recovery Act Research Support The Yale University, W.M. Keck Biotechnology Resource Laboratory's MS and Proteomics Core has developed a state-of-the-art proteomic technology to maximally support Bench-to-Bedside Research. This new service entitled targeted proteomics utilizes an emerg National Institutes of Health 5/27/2010
YALE UNIVERSITY $487,929 Trans-NIH Recovery Act Research Support Infectious diseases caused by pathogenic bacteria and viruses pose a serious challenge to global health. Each year approx 2.9 million people die from AIDS, approx 2 million from tuberculosis and 2 million from bacterially caused diarrhea. Emerging infecti National Institutes of Health 5/13/2010
YALE UNIVERSITY $478,165 Trans-NIH Recovery Act Research Support This application is submitted by a group of investigators at 9 sites distributed throughout the U.S. where there are active developmental research programs involving substantial numbers of typically developing children, and neuroimaging investigators with
This spending item is part of a $8,950,690 allocation. See details
National Institutes of Health 9/30/2009
YALE UNIVERSITY $478,004 Trans-NIH Recovery Act Research Support High resolution structural, functional and spectroscopic magnetic resonance (MR) imagings of the brain are powerful technologies for the study of epilepsy. Image-guided surgical resection has proven to be an effective treatment for many cases of medically National Institutes of Health 9/25/2009
YALE UNIVERSITY $478,004 Trans-NIH Recovery Act Research Support High resolution structural, functional and spectroscopic magnetic resonance (MR) imagings of the brain are powerful technologies for the study of epilepsy. Image-guided surgical resection has proven to be an effective treatment for many cases of medically National Institutes of Health 9/25/2009
YALE UNIVERSITY $457,983 Trans-NIH Recovery Act Research Support Children with asthma may be particularly sensitive to fine particulate matter ( 2.5 m in aerodynamic diameter, PM2.5). The parent grant is investigating the effects of variations in outdoor concentrations of PM2.5 and PM2.5 elemental speciation on asthma National Institutes of Health 9/06/2009
YALE UNIVERSITY $455,125 Trans-NIH Recovery Act Research Support West Nile virus, an NIAID category B priority pathogen, emerged in the United States in 1999, causing over 11,000 cases of neuroinvasive disease and 1,103 fatalities. Because the threat of emerging viral diseases raises new dangers for public safety, it i National Institutes of Health 6/04/2009
YALE UNIVERSITY $455,125 Trans-NIH Recovery Act Research Support The function of most genes in our genome remains a mystery. In order to determine their function, we must use model systems such as frogs specifically Xenopus. In this proposal, we will create new technologies to determine gene function in Xenopus and the National Institutes of Health 7/15/2009
YALE UNIVERSITY $455,125 Trans-NIH Recovery Act Research Support Age-related macular degeneration is the predominant cause of vision loss in adults over 65. Lack of effective treatment stems from both the complexity of the disease, and lack of good animal models in which to study it. This proposal offers the potential National Institutes of Health 7/17/2009
YALE UNIVERSITY $455,125 Trans-NIH Recovery Act Research Support Pain caused by activation of pain-sensing peripheral neurons (nociceptors) is a major source of human suffering and economic loss. Pain sensation requires the coordinated participation of a variety of ion channels. Our long-term goal is the development of National Institutes of Health 5/15/2009
YALE UNIVERSITY $455,125 Trans-NIH Recovery Act Research Support PLUNC is a recently discovered protein that is present in high concentrations in the secretions that bathe the respiratory tract. PLUNC is present in all mammals, yet its functions have not been fully elucidated. Our early studies show that PLUNC regulate National Institutes of Health 7/21/2009
YALE UNIVERSITY $455,125 Trans-NIH Recovery Act Research Support The goal of this project is to analyze the dynamic changes that occur at a cellular and molecular level during synaptic development and plasticity. These events will be examined in a well characterized genetic model system, the Drosophila neuromuscular ju National Institutes of Health 6/01/2009
YALE UNIVERSITY $455,125 Trans-NIH Recovery Act Research Support Ixodes scapularis ticks transmit Borrelia burgdorferi, the agent of Lyme disease among other pathogens. In this proposal we will identify tick midgut proteins that interact with Borrelia during spirochete growth and migration and examine the impact of thi National Institutes of Health 6/04/2009
YALE UNIVERSITY $455,000 Trans-NIH Recovery Act Research Support We are requesting fund to purchase an Amis Image Stream, a unique instrument that combines flow cytometry with optical imaging to create a rea- sonbly detailed representation of each cell that passes through the chamber. This image is assembled from multi National Institutes of Health 1/25/2010
YALE UNIVERSITY $454,081 Trans-NIH Recovery Act Research Support Heart Failure affects over 5 million Americans and is associated with poor functioning, negative symptoms, and poor quality of life. Insomnia, a disorder of initiating and maintaining sleep, is common in these patients and contributes to daytime symptoms National Institutes of Health 8/13/2009
YALE UNIVERSITY $453,547 Trans-NIH Recovery Act Research Support Stress is a well known risk factor for relapse in alcohol-dependence. The goal of this project is to identify specific stress-related genes that may predict the risk for relapse in alcohol dependent subjects and allow individuals at higher-risk to be dire National Institutes of Health 8/20/2009
YALE UNIVERSITY $443,892 Trans-NIH Recovery Act Research Support Morbidity and mortality associated with severe infections caused by Staphylococcus aureus present a staggering burden on the healthcare in the United States. The increasing antibiotic resistance of S. aureus limits effectiveness of available antibiotic th National Institutes of Health 5/14/2009
YALE UNIVERSITY $438,880 Trans-NIH Recovery Act Research Support Sleep is an essential biological function that has physiological, behavioral and temporal characteristics. It is regulated by homeostatic and circadian processes. The knowledge of the importance of sleep and the adverse effects of sleep deprivation has gr National Institutes of Health 9/01/2009
YALE UNIVERSITY $433,362 Trans-NIH Recovery Act Research Support Memory CD8 T cells are a critical component of adaptive immunity that protect us against infectious disease and even cancer, however the mechanisms for how these cells develop during infection or vaccination are not clear. The ultimate goal of this propos National Institutes of Health 5/21/2009
YALE UNIVERSITY $428,385 Trans-NIH Recovery Act Research Support We are requesting funds for the acquisition of a BD FACSAria II Cell-sorting instrument. The researchers on the Science Hill campus of Yale University have extensive microscopy experience for their cell, stem cell and developmental biology research progra National Institutes of Health 5/20/2010
YALE UNIVERSITY $422,057 Trans-NIH Recovery Act Research Support 'High-speed, wide field fluorescent imaging of cortex in freely moving animals This project will produce a miniature microscope/imaging system which can be head mounted and will allow the recording of optical signals of changes in membrane voltage and ca
This spending item is part of a $1,189,290 allocation. See details
National Institutes of Health 7/20/2009
YALE UNIVERSITY $419,520 Trans-NIH Recovery Act Research Support An individual's sensitivity to aversive drug effects is likely to be important not only in the manifestations and course of drug dependence (e.g., in experienced users) but also in the predisposition and/or progression to addiction (e.g., in inexperienced National Institutes of Health 8/31/2009
YALE UNIVERSITY $415,650 Trans-NIH Recovery Act Research Support As requested by RFA-HD-04-002 entitled 'Genomic and Proteomic Network for Premature Birth Research,' we propose to establish a Data Management, Statistics, and Informatics Core at Yale University as a part of the Network. We will be responsible for the ce National Institutes of Health 9/22/2010
YALE UNIVERSITY $413,750 Trans-NIH Recovery Act Research Support Opportunistic infections are the primary cause of suffering and death in individuals with AIDS. Many of these infections are produced by parasites that rarely affect individuals who are not immunocompromised. Unfortunately, successful combination therapie National Institutes of Health 6/11/2009
YALE UNIVERSITY $413,275 Trans-NIH Recovery Act Research Support The transcription states of genes are either stable or flexible, which has clear biological importance. Also, evidence is mounting that exogenous insults acting on fetus can cause irreversible damages to chromatin (called epimutations), impairing gene fun National Institutes of Health 7/21/2010
CORNELL SCOTT-HILL HEALTH CORPORATION $399,511 ARRA Health Center Integrated Services Development Initiative[g1] Grant Name: Increased Demand for Services (IDS) Purpose: To utilize IDS funds to perform provider and staff recruitment and retention activities, expand hours, and conduct outreach and health promotion activities. Goals: 1. Conduct com... Show more Health Resources and Services Administration 3/27/2009
YALE UNIVERSITY $399,089 Trans-NIH Recovery Act Research Support The immunologic events that lead to the development of Type 1 diabetes mellitus (T1DM) are not clearly defined. Understanding the immunologic events that lead to beta cell destruction is an important goal of mechanistic studies since they are likely to su National Institutes of Health 9/30/2010
YALE UNIVERSITY $395,450 Trans-NIH Recovery Act Research Support The proposed studies of redox sites in photosystem II address fundamental aspects of catalysis that are ubiquitous in metabolic mechanisms of metalloenzymes common to different classes of organisms from bacteria to humans (e.g., P-450s, peroxidases and ox National Institutes of Health 8/14/2009
TEAM INC $392,033 ARRA - Community Services Block Grant ARRA Supplemental Funding for the Community Services Block Grant (CSBG) Program provides economic stimulus by advancing the economic and social well-being of low-income individuals and families of the state of Connecticut. With an award of $12,060,854, 9
This spending item is part of a $12,060,854 allocation. See details
Administration for Children and Families 4/10/2009
YALE UNIVERSITY $389,125 Trans-NIH Recovery Act Research Support The molecular mechanism of antipsychotic drug action is not well understood. Several studies have reported the brain region specific induction of DNA-binding proteins (transcription factors, TF) by these drugs. The functional activity of these transcripti National Institutes of Health 5/13/2009
YALE UNIVERSITY $389,125 Trans-NIH Recovery Act Research Support Defining the neural pathways and circuits of the brain is critical for understanding neurological and psychiatric disease. The proposed experiments will characterize how brain reward circuits respond to changes in levels of a hormone that is produced in f National Institutes of Health 5/21/2009
YALE UNIVERSITY $371,314 Trans-NIH Recovery Act Research Support The central goal of the Yale Center of Excellence in Molecular Hematology is to facilitate ongoing collaborative research designed to understand and manipulate gene expression and regulation related to the self-renewal, proliferation and differentiation o National Institutes of Health 3/11/2010
YALE UNIVERSITY $361,109 Trans-NIH Recovery Act Research Support With this analytic epidemiologic study, we begin investigating situations in which the treatment of one condition may exacerbate other conditions or adversely affect other health outcomes. Despite potential harms to the large number of older individuals w Agency for Healthcare Research and Quality 9/28/2010
YALE UNIVERSITY $360,940 Trans-NIH Recovery Act Research Support Large-scale efforts are underway to systematically map transcription factors binding sites throughout the human genome. The ENCODE project has focused its initial attention on two cell lines, 1) K562 cells, a myeloid precursor cell line and 2) GM12878, a
This spending item is part of a $1,312,500 allocation. See details
National Institutes of Health 9/30/2009
YALE UNIVERSITY $349,258 Trans-NIH Recovery Act Research Support Alveolar destruction and pulmonary fibrosis are juxtaposed in COPD and pulmonary fibrosis. Surprisingly, the relationships between these responses and the mechanisms that destroy alveoli while simultaneously nducing fibrosis have not been defined. Transfo National Institutes of Health 7/20/2009
YALE UNIVERSITY $343,565 Trans-NIH Recovery Act Research Support This is an application for support from the Recovery Act Limited Competition for NIH Grants: Research to Address the Heterogeneity in Autism Spectrum Disorders (R01) RFA-MH-09-170. We propose to leverage ongoing collaboration among faculty at Duke Univers
This spending item is part of a $1,616,415 allocation. See details
National Institutes of Health 9/30/2009
YALE UNIVERSITY $334,673 Trans-NIH Recovery Act Research Support Prediabetes, the transition phase between normal glucose tolerance and T2DM, is a crucial time for intervention as the progression to T2DM in children is more rapid than in adults. We have shown that 1 out of every 4-5 obese children seen in the Yale Pedi
This spending item is part of a $386,633 allocation. See details
National Institutes of Health 9/24/2009
YALE UNIVERSITY $331,000 Trans-NIH Recovery Act Research Support Core C, the Cell Culture and Animal Models Core, is an integrated, dedicated, essential component of the Program, which will provide materials and services to all four Projects of the Program. This Core supports the Projects by providing specialized cell National Institutes of Health 9/17/2009
YALE UNIVERSITY $331,000 Trans-NIH Recovery Act Research Support The Yale Diabetes Endocrinology Research Center was established in the Spring of 1993 with the goal of promoting research in diabetes and related metabolic and endocrine disorders at the University. The Center brings together a multidisciplinary group of National Institutes of Health 12/04/2009
YALE UNIVERSITY $330,265 Trans-NIH Recovery Act Research Support The mechanisms of successful long-term vein graft adaptation to the arterial environment without excessive intimal thickening are still not completely understood. Several members of the Ephrin-Eph pathway have recently been described as developmentally sp National Institutes of Health 7/16/2009
YALE UNIVERSITY $329,886 Trans-NIH Recovery Act Research Support The Coordinating and Bioinformatics Unit (CBU) for the Animal Models of Diabetic Complications Consortium (AMDCC) and the Mouse Metabolic Phenotyping Centers (MMPC) is responsible for creating and maintaining the administrative, scientific and informatics
This spending item is part of a $1,819,749 allocation. See details
National Institutes of Health 9/28/2009
YALE UNIVERSITY $316,634 Trans-NIH Recovery Act Research Support Patients with an acute coronary syndrome (ACS) and comorbid depression have a 2-fold higher risk for recurrent ACS and mortality, worse quality of life, and higher costs of care than nondepressed ACS patients. The strength of these findings prompted the A
This spending item is part of a $4,136,888 allocation. See details
National Institutes of Health 9/28/2009
YALE UNIVERSITY $313,169 Trans-NIH Recovery Act Research Support Acute kidney injury (AKI) is common in patients undergoing cardiac surgery. Even small increases in serum creatinine portend an increased risk of short-term and long-term death. Serum creatinine, the traditional marker of renal function, only rises appr National Institutes of Health 7/16/2009
YALE UNIVERSITY $312,953 Trans-NIH Recovery Act Research Support Metastasis is the major cause of mortality for cancer patients. However, the genetic basis for tumor progression and metastasis is largely unknown. It has been difficult to systematically dissect the mechanisms underlying these two disease processes in pa National Institutes of Health 8/28/2009
YALE UNIVERSITY $306,297 Trans-NIH Recovery Act Research Support The aims of the ENCODE (Encyclopedia of DNA Elements) and modENCODE (model organism ENCODE) projects are to apply high-throughput, cost-efficient approaches to generate a catalog of functional elements in the human, worm, and fly genomes, which will serve
This spending item is part of a $2,789,724 allocation. See details
National Institutes of Health 9/30/2009
YALE UNIVERSITY $303,329 Trans-NIH Recovery Act Research Support Stroke is a major cause of morbidity and mortality in the United States and presents challenges in the development of disease prevention strategies. Deprivation of nutrients and oxygen supply to brain cells produces immediate death in the most severely af National Institutes of Health 8/17/2009
GRIFFIN HOSPITAL INC, THE $299,997 ARRA ? Equipment to Enhance Training for Health Professionals Equipment to Improve Training in Primary Care Medicine: Distance learning equipment, patient evaluation and clinical examination equipment, clinical simulation equipment. 1) Equipment to facilitate Distance Learning (Video-conferenc... Show more Health Resources and Services Administration 9/07/2010
YALE UNIVERSITY $299,240 Trans-NIH Recovery Act Research Support The brain organizes information about the sensory world into maps. Prominent examples are the maps of eye-preference and retinotopy in the lateral geniculate nucleus, superior colliculus and visual cortex. Experiments in this proposal will advance our und National Institutes of Health 9/30/2009
YALE UNIVERSITY $296,930 Trans-NIH Recovery Act Research Support This application is in response to NIH Notice NOT-OD-09-056 for supplemental support for the Yale Liver Center P30-34989, an NIDDK Digestive Disease Center grant. This Supplement will advance the objectives of the ARRA by 1) Accelerating the pace of scien National Institutes of Health 7/17/2009
YALE-NEW HAVEN HEALTH SERVICES CORPORATION $292,840 ARRA ? Equipment to Enhance Training for Health Professionals Grant Name: HRSA-10-259: ARRA Equipment to Enhance Training for Health Professionals, Post-Doc General, Pediatric and Public Health Dentistry Grant Purpose: HRSA Funding was requested and was changed to provide the equipment for the 1 L... Show more Health Resources and Services Administration 9/05/2010
YALE UNIVERSITY $290,304 Trans-NIH Recovery Act Research Support One of the biggest challenges moving discovery to clinical intervention is the timely and cost effective launching and completion of clinical research studies and the development of support models to aid clinical research management. The Clinical and Tran National Institutes of Health 9/25/2009
YALE UNIVERSITY $288,433 Trans-NIH Recovery Act Research Support The research program features state-of-the-art computational design, organic synthesis, biological assaying, and crystallography aimed at delivering clinical candidates with striking potential for combating HIV/AIDS. The aims are to (1) develop improved t National Institutes of Health 9/22/2009
YALE UNIVERSITY $288,402 Trans-NIH Recovery Act Research Support Exocytosis is a fundamental cell biological process in all eukaryotic cells, through which intracellular molecules are secreted and the levels of membrane proteins and lipids are regulated. The work proposed here focuses on the exocyst, a multimeric, ~800 National Institutes of Health 9/25/2009
YALE UNIVERSITY $287,970 Trans-NIH Recovery Act Research Support The ability of retroviruses to efficiently manipulate cell-cell contacts for the purpose of spreading critically contributes to the progression to retrovirally induced diseases such as leukemia and AIDS. Our grant 2R01CA098727 is devoted to the determinat National Institutes of Health 9/18/2009
FAIR HAVEN COMMUNITY HEALTH CLINIC INC $282,251 ARRA Health Center Integrated Services Development Initiative[g1] The Fair Haven Community Health Center (FHCHC) will utilize IDS funds to expand and enhance our clinic capacity and hours. We will 1) To increase capacity in the evenings from 5:00PM until 9:00PM, 4 evenings a week and on Saturday mo... Show more Health Resources and Services Administration 3/27/2009
ALL OUR KIN $277,235 ARRA - Head Start UWGNH is providing full-day, full-year Early Head Start program services to 41 infants and toddlers through three delegates. Two delegates are providing center-based care; the third delegate is providing licensed family child care. All of the children a
This spending item is part of a $1,141,969 allocation. See details
Administration for Children and Families 12/17/2009
YALE UNIVERSITY $274,801 Trans-NIH Recovery Act Research Support Reversible protein phosphorylation is one of the most common mechanisms for regulating cell behavior in eukaryotes. Genome sequencing efforts have uncovered hundreds of new predicted protein kinases. For most, we have little insight into their biological National Institutes of Health 9/30/2009
YALE UNIVERSITY $273,850 Trans-NIH Recovery Act Research Support The present administrative supplement will allow us TO HIRE VALERIE GORDON AND KEEP MARY MORGAN TAYLOR IN THE LAB FOR ONE MORE YEAR before they each join graduate school. Valerie has worked in the lab as an undergraduate student for the past 3 years and w National Institutes of Health 7/17/2009
STAYWELL HEALTH CARE, INC. $271,184 ARRA Health Center Integrated Services Development Initiative[g1] StayWell Health Center was awarded ARRA funds in order to support the expected increase in uninsured and new patients to the community health center. Health Resources and Services Administration 3/27/2009
STAYWELL HEALTH CARE, INC. $271,184 ARRA Health Center Integrated Services Development Initiative[g1] StayWell Health Center has been awarded funds to support increased utilization by patients who are newly uninsured or under-insured. Health Resources and Services Administration 3/27/2009
STAYWELL HEALTH CARE, INC. $270,184 ARRA - Increase Services to Health Centers Health Resources and Services Administration 3/27/2009
YALE UNIVERSITY $270,000 Trans-NIH Recovery Act Research Support The world faces a wide array of Global Health challenges, including the HIV pandemic, the threat of an influenza pandemic, the resurgence of tuberculosis and malaria, continued malnutrition in low-income countries, and the spread of cigarette smoking and National Institutes of Health 5/06/2009
YALE UNIVERSITY $264,800 Trans-NIH Recovery Act Research Support The proposal here addresses two related questions that are direct extensions of our parent grant on MCH neurons. Despite many papers on the role of MCH in energy homeostasis and emotional states, and the expression of MCH axons and receptors detected by h National Institutes of Health 8/20/2009
YALE UNIVERSITY $264,299 Trans-NIH Recovery Act Research Support The goal of these studies is to understand the properties of naturally occurring immune responses against cancer stem cells in people without cancer. Harnessing such responses may be important for prevention of cancer, such as myeloma. National Institutes of Health 9/15/2009
NEW OPPORTUNITIES, INC. $260,210 ARRA - Head Start Cost-of-living adjustment (COLA) increase of 1.84% in the amount of $61,987 for Head Start and $10,152 for Early Head Start. Quality improvement funds of $162,131 for Head Start and $25,940 for Early Head Start. Administration for Children and Families 7/29/2009
YALE UNIVERSITY $258,350 Trans-NIH Recovery Act Research Support This supplement is requested to develop a version of the existing CBT4CBT program that is applicable to alcohol using individuals, using a web-based format. The CBT4CBT program was developed for drug abusers and in a DVD/CD Rom format, largely because at National Institutes of Health 9/21/2009
YALE UNIVERSITY $254,118 Trans-NIH Recovery Act Research Support PROJECT SUMMARY: Proper functioning of the cell cycle and its regulation in response to both internal and external stimuli is essential for the normal growth, division, and differentiation of cells and tissues. Major control over cell cycle progression is National Institutes of Health 9/30/2009
YALE UNIVERSITY $253,867 Trans-NIH Recovery Act Research Support The overall goals of this project are to define the common molecular mechanisms in the pathogenesis of biliary cirrhosis. Biliary cirrhosis accounts for approximately 20 percent of cases liver failure in adults and more than 50 percent of cases ofliver fa National Institutes of Health 7/15/2010
YALE UNIVERSITY $250,319 Trans-NIH Recovery Act Research Support Dr Dunne received this ARRA grant as a Biomedical Reentry Grant funded as a supplement to Dr Erol Fikrigs R37 award. The intent of Dr Dunne?s supplement is to supply her with mentorship and skill set development to become an independent investigator. Dr National Institutes of Health 9/11/2009
YALE UNIVERSITY $248,250 Trans-NIH Recovery Act Research Support This Competitive Revision of my currently funded RO1 (DE DE012459-12) is submitted in response to, and in accordance with Notice Number NOT-OD-09-058, titled, NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. One National Institutes of Health 9/25/2009
YALE UNIVERSITY $245,500 Trans-NIH Recovery Act Research Support An administrative supplement is requested for the George M. OBrien Kidney Center at Yale. The principal goal of the Yale Center is to provide renal investigators both at Yale and across the country with access to highly specialized services not otherwise National Institutes of Health 8/10/2009
YALE UNIVERSITY $238,906 Trans-NIH Recovery Act Research Support The long-term goal of this project is to understand how ring canals contribute to cell function. Ring canals ubiquitous in developing germline cells in the animal kingdom, and are required for fertility. They form ring mitotic proliferation of germline st National Institutes of Health 9/30/2009
YALE UNIVERSITY $234,086 Trans-NIH Recovery Act Research Support The contributions of anatomy and biophysical properties to the function of neurons and neural circuits are best understood with the aid of computer simulations. NEURON, a program which we have developed and provide freely for Mac OS X, MS Windows, and UNI National Institutes of Health 8/17/2009
YALE UNIVERSITY $220,112 Trans-NIH Recovery Act Research Support Tourette Syndrome (TS) is a neurological disorder characterized by persistent motor and vocal tics. Tics can be brief, rapid and darting movements of the face, shoulders, and extremities or more complex and purposeful in appearance. Vocal tics can be simp National Institutes of Health 7/22/2009
YALE UNIVERSITY $215,450 Trans-NIH Recovery Act Research Support Our project is based on the use of a water-soluble membrane peptide, pHLIP, by whole-body fluorescence and PET imaging, to selectively target acidic solid tumors in vivo and to translocate polar cargo molecules into the cytoplasms of cultured cancer cell
This spending item is part of a $581,599 allocation. See details
National Institutes of Health 9/15/2009
YALE UNIVERSITY $213,972 Trans-NIH Recovery Act Research Support The Yale Center for Clinical Investigation (YCCI) is the administrative home for the CTSA at Yale University School of Medicine. This supplemental proposal will advance YCCI community outreach through collaboration with the NIH SEPA grant based at the Ya National Institutes of Health 9/23/2009
Insite One Inc $203,204 The Contractor shall provide services to the National Institute of Biomedical Imaging and Bioengineering (NIBIB) in the design, development, and launch of an Internet-based network for patient-controlled medical image sharing built upon the Integrating th
This spending item is part of a $4,697,377 allocation. See details
National Institutes of Health 9/30/2009
YALE UNIVERSITY $201,440 Trans-NIH Recovery Act Research Support The main objectives of this proposal are; (i) To determine if base selection by RB69 pol is governed by a conformational change before chemistry or by the nucleotidyl transfer step itself; (ii) To understand how the triple mutant, that we have produced, c National Institutes of Health 7/17/2009
YALE UNIVERSITY $200,003 Trans-NIH Recovery Act Research Support Craniofacial malformations are among the most common birth defects in children and lead to substantial morbidity and mortality for these infants. Despite the severity of the illness, little is known about the molecular mechanisms that are necessary for co National Institutes of Health 9/22/2009
HASKINS LABORATORIES, INC. $198,303 Trans-NIH Recovery Act Research Support Nature and Acquisition of the Speech Code and Reading. Administrative Supplement for HD-001994, Project III. National Institutes of Health 9/01/2010
YALE UNIVERSITY $194,700 Trans-NIH Recovery Act Research Support The proposed experiments will directly impact public health by developing a novel paradigm to investigate nicotine-induced dopamine release in vivo. These studies will examine the effects of nicotine and the treatment drug rimonabant in the brain to deter National Institutes of Health 5/04/2009
YALE UNIVERSITY $192,314 Trans-NIH Recovery Act Research Support Autoantibodies are a characteristic of most autoimmune diseases including rheumatoid arthritis (RA) and appear in the serum many years before the onset of clinical disease, suggesting an early break in B cell tolerance in RA. An important role for B cells National Institutes of Health 8/30/2010
YALE UNIVERSITY $188,870 Trans-NIH Recovery Act Research Support The primary goal of this supplementary application is to develop a potent beta-peptide agonist of the GLP-1 receptor, a validated target for the treatment of type 2 diabetes. The experimental plan builds solidly on a foundation of results obtained in our National Institutes of Health 9/30/2009
YALE UNIVERSITY $186,778 Trans-NIH Recovery Act Research Support We study the structure and function of group II introns, which are large ribozymes that function as selfsplicing RNAs and mobile genetic elements. Group II introns are important model systems for understanding RNA tertiary structure, RNA folding, and for National Institutes of Health 9/28/2009
YALE UNIVERSITY $186,034 Trans-NIH Recovery Act Research Support The long-term goal of our research is to elucidate the cellular and circuit mechanisms of decision making and its executive control. Flexible behavior in humans and animals relies on the brain's ability to accumulate information over time, deliberate abou National Institutes of Health 9/30/2009
YALE UNIVERSITY $184,890 Trans-NIH Recovery Act Research Support Our primary defense against infectious disease and re-occurring illness are memory T and B cells. These critical arms of the immune system can also be potent aggressors against many forms of cancer. Developing effective vaccines to prevent infection and t National Institutes of Health 7/26/2010
YALE UNIVERSITY $183,866 Trans-NIH Recovery Act Research Support As life expectancy in the US continues to rise, the maintenance of independence among older Americans has emerged as a major clinical and public health priority. Efficient and reliable locomotion, or the ability to move without assistance, is a fundamenta
This spending item is part of a $1,524,000 allocation. See details
National Institutes of Health 3/31/2010
YALE UNIVERSITY $182,875 Trans-NIH Recovery Act Research Support We propose to conduct a genome-wide association study to identify loci involved in endometrial cancer causation. We plan to utilize studies with available biospecimens, 6 cohorts from the NCI Cohort Consortium and 7 case-control studies, within the NCI Ep
This spending item is part of a $4,309,389 allocation. See details
National Institutes of Health 9/30/2009
L2 DIAGNOSTICS LLC $182,436 Trans-NIH Recovery Act Research Support The mammalian innate immunity is the first line of the host defense against invading pathogens including viruses. Within the host, antigen-presenting cells such as dendritic cells and macrophages, express a variety of pattern recognition receptors (PRRs) National Institutes of Health 9/01/2009
YALE UNIVERSITY $177,242 Trans-NIH Recovery Act Research Support Connective tissues, which include skin, fascia, ligament, tendon, blood vessel, etc, all rely upon extracellular matrix to provide the bulk of their mechanical properties. Collagenous extracellular matrix provides the tensile load bearing properties in al National Institutes of Health 8/13/2009
Lulac Head Start $170,411 ARRA - Head Start UWGNH is providing full-day, full-year Early Head Start program services to 41 infants and toddlers through three delegates. Two delegates are providing center-based care; the third delegate is providing licensed family child care. All of the children a
This spending item is part of a $1,141,969 allocation. See details
Administration for Children and Families 12/17/2009
YALE UNIVERSITY $169,782 Trans-NIH Recovery Act Research Support As life expectancy in the US continues to rise, the maintenance of independence among older Americans has emerged as a major clinical and public health priority. Efficient and reliable locomotion, or the ability to move without assistance, is a fundamenta
This spending item is part of a $1,524,000 allocation. See details
National Institutes of Health 3/31/2010
YALE UNIVERSITY $168,810 Trans-NIH Recovery Act Research Support Epithelial ovarian cancer (EOC) is the fourth leading cause of cancer-related death in women in the United States and is the leading cause of gynecologic cancer death. A major limitation in the treatment of ovarian cancer is the widespread development of National Institutes of Health 6/01/2009
YALE UNIVERSITY $168,547 Trans-NIH Recovery Act Research Support The human brain consists of approximately 100 billion neurons, which form over 100 trillion synapses with specific targets. How neurons find the correct targets and how the correct wiring of the brain influences behavior are central questions, and the foc National Institutes of Health 9/28/2009
YALE UNIVERSITY $166,733 Trans-NIH Recovery Act Research Support Endothelial cells (EC) in the heart play a variety of important roles both during development and in the adult animal. Cardiac EC are uniquely poised to act as sensors of systemic stress (by virtue of exposure to circulating factors) as well as sensors an National Institutes of Health 7/16/2009
YALE UNIVERSITY $165,500 Trans-NIH Recovery Act Research Support This research investigates the role of young children's attitudes toward privilege in the development and maintenance of social group attitudes including social class and racial attitudes. There is now considerable evidence that experienced and perceived National Institutes of Health 9/10/2009
YALE UNIVERSITY $165,500 Trans-NIH Recovery Act Research Support Hypoglycemia remains the major factor limiting the use of intensified insulin therapy that has been shown to prevent complications in type 1 diabetes (T1DM). This MERIT extension proposal continues studies focused on the mechanisms that trigger glucose co National Institutes of Health 3/15/2010
YALE UNIVERSITY $165,500 Trans-NIH Recovery Act Research Support The results of this project will provide crucial information that will improve the effectiveness of Lyme Disease prevention methods directed towards wildlife reservoirs, such as vaccinating wildlife. This project provides a method to identify the wildlife National Institutes of Health 6/18/2009
YALE UNIVERSITY $165,500 Trans-NIH Recovery Act Research Support Membrane fusion is central to many areas of endocrine and exocrine physiology, and imbalances in these processes give rise to important diseases, such as diabetes. As a result of the work supported by this grant during the current cycle of funding, the co National Institutes of Health 3/22/2010
YALE UNIVERSITY $164,912 Trans-NIH Recovery Act Research Support Systemic lupus erythematosus (SLE) is a life-threatening disease, in which antibodies against self-proteins damage various organs. The self-proteins that are responsible for the initiation of SLE still remain unknown. We have shown that posttranslationall National Institutes of Health 7/17/2009
YALE UNIVERSITY $164,321 Trans-NIH Recovery Act Research Support The primary goal of this supplement is to investigate the role of retinaldehyde (Rald) in skeletal homeostasis and bone marrow adiposity. Our investigative group is studying the interaction between skeletal acquisition and bone marrow adiposity, and test
This spending item is part of a $812,444 allocation. See details
National Institutes of Health 9/23/2009
YALE UNIVERSITY $163,896 Trans-NIH Recovery Act Research Support The neurotransmitter serotonin plays an important role in the development of depression. Serotonin is one of the brain's natural chemicals. Serotonin binds to serotonin receptors (binding sites) type 1B on brain cells to regulate emotion, anxiety, sleep, National Institutes of Health 5/14/2009
YALE UNIVERSITY $161,621 The Cancer Knowledge Cloud will connect and share information generated through NCI genomic atlas projects, the caHUB tissue acquisition network, the NCI functional Biology Consortium, NCI patient Characterization Center, the NCI pre-clinical Development
This spending item is part of a $103,000,000 allocation. See details
National Institutes of Health 11/23/2009
YALE UNIVERSITY $160,681 Trans-NIH Recovery Act Research Support NIH Grant Number -- 3R21HG004764-02S1: DNA Transport and Sequencing through a Quadrupole Gate: This award provides funding from the National Institutes of Health (NIH). The purpose of this project is to develop a high speed device for sequencing a sing
This spending item is part of a $278,725 allocation. See details
National Institutes of Health 9/30/2009
YALE UNIVERSITY $160,295 Trans-NIH Recovery Act Research Support Symbiotic microbial relations are extremely pervasive, with examples being found among all levels of the earth's biota. These associations vary with regard to their interactive nature, and are characterized by the benefit (or detriment) imparted to the pa National Institutes of Health 9/18/2009
YALE UNIVERSITY $159,900 Trans-NIH Recovery Act Research Support This proposal seeks to acquire a Cellvizio confocal endomicroscopic imaging system for Yale Medical School. The ongoing renaissance in the use of light microscopy for cell and molecular biology and physiology has been driven in large part by the developme National Institutes of Health 4/08/2010
YALE UNIVERSITY $158,175 Trans-NIH Recovery Act Research Support The transmission of group B streptococcus from colonized women to their newborns during labor can be attenuated by treating women with intravenous antibiotic during labor. Current protocols from the CDC direct invasive testing and intensified surveillance National Institutes of Health 7/22/2009
YALE UNIVERSITY $155,502 Trans-NIH Recovery Act Research Support Interventions to promote continued abstinence and the avoidance of risky sexual behaviors are far more likely to be successful than attempts to alter established patterns of high-risk sexual activity. The proposed project is a randomized, controlled trial National Institutes of Health 9/30/2009
YALE UNIVERSITY $153,791 Trans-NIH Recovery Act Research Support The ribosome is the catalyst of protein synthesis in all living organisms. The peptidyl transferase center (PTC) is an evolutionarily ancient active site, extensively conserved through all biological kingdoms, with regard to both its sequence and its sub National Institutes of Health 9/30/2009
YALE UNIVERSITY $149,772 Trans-NIH Recovery Act Research Support This project, Prevention Trial of Family Focused Treatment in Youth at Risk for Psychosis, is a multi-site study (UCLA, Yale, Emory, University of North Carolina) testing the efficacy of a family-focused psychosocial intervention in the prevention of func
This spending item is part of a $969,718 allocation. See details
National Institutes of Health 9/30/2009
AGENCY ON AGING OF SOUTH CENTRAL CONNECTICUT, INC. $148,170 Aging Congregate Nutrition Services for States ARRA provided funding for Congregate Nutrition Services. Established in 1972 under the Older Americans Act, the program provides meals to older Americans in congregate facilities such as senior centers, adult day centers, and faith-based settings.
This spending item is part of a $775,759 allocation. See details
Administration on Aging 3/18/2009
Western Connecticut Area Agency On Aging Inc $145,067 Aging Congregate Nutrition Services for States ARRA provided funding for Congregate Nutrition Services. Established in 1972 under the Older Americans Act, the program provides meals to older Americans in congregate facilities such as senior centers, adult day centers, and faith-based settings.
This spending item is part of a $775,759 allocation. See details
Administration on Aging 3/18/2009
YALE UNIVERSITY $143,887 Trans-NIH Recovery Act Research Support Endometriosis is one of the most common benign gynecologic disorders affecting approximately 10% of women in reproductive age. It is associated with significant morbidity, including infertility and chronic pelvic pain. The annual cost of endometriosis in
This spending item is part of a $217,517 allocation. See details
National Institutes of Health 9/28/2009
YALE UNIVERSITY $141,597 Trans-NIH Recovery Act Research Support Nephrogenic Systemic Fibrosis (NSF) is a disabling dermatologic adverse drug reaction associated with Gadolinium Containing Chelating Agents (GCCAs). Dermatologic adverse drug reactions (dADRs) are important and poorly characterized causes of morbidity an
This spending item is part of a $1,219,042 allocation. See details
National Institutes of Health 8/11/2009
YALE UNIVERSITY $140,443 Trans-NIH Recovery Act Research Support A tremendous amount of cellular metabolism is dedicated to producing ribosomes, the large ribonucleoprotein factories of protein synthesis responsible for translating mRNAs into proteins. Ribosomes are synthesized in the nucleolus following a series of en National Institutes of Health 7/17/2009
YALE UNIVERSITY $138,262 Trans-NIH Recovery Act Research Support The real-time chemistry of life occurs at the interfaces of proteins and small chemicals present in the cellular environment. For the first time in history, sufficient information on the human proteome and its interacting chemogenome has accumulated in th
This spending item is part of a $2,093,862 allocation. See details
National Institutes of Health 7/16/2010
YALE UNIVERSITY $135,351 Trans-NIH Recovery Act Research Support An administrative supplement is requested for a grant that has two broad research themes: the roles of anion transporter SLC26A6 and related transporters in proximal tubule NaCl transport; and the roles of SLC26A6 and related transporters in mediating int National Institutes of Health 9/24/2009
YALE UNIVERSITY $133,500 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic, 04-AR-101: Autoimmunity For Diseases Of The Skin, Joints, Muscle And Other Tissues-Develop reagents and analytic methods to identify, characterize, track,
This spending item is part of a $999,659 allocation. See details
National Institutes of Health 9/21/2009
YALE UNIVERSITY $130,400 Trans-NIH Recovery Act Research Support Many men with prostate cancer will be affected by side effects of hormonal therapy. The impact of hormonal therapy for prostate cancer on cognitive function, a major determinant of quality of life, remains unclear. This study proposes to use brain imaging National Institutes of Health 7/16/2009
The Consultation Center Inc $127,278 Trans-NIH Recovery Act Research Support The goal of this project is to test risk and resiliency pathways linking social determinants of health and child characteristics to young children's health. We will examine the role of four social determinants of health (i.e., social position, racism, seg
This spending item is part of a $1,035,964 allocation. See details
National Institutes of Health 9/30/2009
YALE UNIVERSITY $124,375 The Yale University has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of melanoma cases. These cases are all primary and untreated. The collection National Institutes of Health 5/04/2010
YALE UNIVERSITY $124,125 Trans-NIH Recovery Act Research Support Marrow adiposity has long been identified as a component of the bone marrow micro-environment, although its function, relevance to mineral metabolism and relationship to energy homeostasis has been ignored until recently. Adipocytes originate from a commo
This spending item is part of a $501,085 allocation. See details
National Institutes of Health 12/18/2009
YALE UNIVERSITY $121,484 Trans-NIH Recovery Act Research Support Performance Indices of Social Disability in Toddlers with Autism' - addresses Challenge Area '(04) Clinical Research' and Specific Challenge Topic 'Autism: Addressing the Challenge (04-MH-101*)'; and Challenge Area '(01) Behavior, Behavioral Change, and P National Institutes of Health 5/18/2010
YALE UNIVERSITY $121,295 Trans-NIH Recovery Act Research Support Grant Number 2R01 GM047297 Mechanisms of Phosphoryl Transfer This project studies several enzymes involved in controlling the levels of phosphorylation of proteins in humans, a factor in many diseases. Abstract The project will utilize a multidisciplina
This spending item is part of a $612,216 allocation. See details
National Institutes of Health 9/17/2009
YALE UNIVERSITY $120,049 Trans-NIH Recovery Act Research Support Glutamate-receptor ion channels (iGluRs) participate in brain functions that range from fast synaptic transmission to activity-dependent changes that underlie certain forms of learning and memory. These receptors are also implicated in a variety of excito National Institutes of Health 8/11/2009
YALE UNIVERSITY $118,144 Trans-NIH Recovery Act Research Support MicroRNAs (miRNAs) constitute a novel class of gene regulatory elements with important roles in the control of gene expression and development in plants and animals. miRNAs are endogenous, small non-coding RNAs which inhibit gene expression by base pairin National Institutes of Health 7/21/2009
YALE UNIVERSITY $116,454 Trans-NIH Recovery Act Research Support Innate immunity via Toll Like Receptors (TLRs) is the first line of defense against microbial invasion and is essential for pathogen detection. Our preliminary data, using experimental murine systems, also demonstrates that TLR dependent immunity is impor National Institutes of Health 8/02/2010
Life Haven Inc $116,420 ARRA - Head Start UWGNH is providing full-day, full-year Early Head Start program services to 41 infants and toddlers through three delegates. Two delegates are providing center-based care; the third delegate is providing licensed family child care. All of the children a
This spending item is part of a $1,141,969 allocation. See details
Administration for Children and Families 12/17/2009
YALE UNIVERSITY $115,937 Trans-NIH Recovery Act Research Support The recent resurgence of important infectious diseases has led to a need for K-12 school curricula that create a better understanding of disease transmission dynamics and their biological underpinnings. To produce these curricula, Lyme disease and West Ni National Institutes of Health 9/04/2009
WESTERN CONNECTICUT AREA AGENCY ON AGING INC $112,100 ARRA - Communities Putting Prevention to Work: Chronic Disease Self-Manage In collaboration with the Recovery Act-funded Communities Putting Prevention to Work (CPPW) program, this funding will support the deployment of evidence-based chronic disease self-management programs that empower older peopl... Show more
This spending item is part of a $400,000 allocation. See details
Administration on Aging 3/26/2010
YALE UNIVERSITY $111,757 Trans-NIH Recovery Act Research Support The proposed longitudinal study is designed to examine reading development at critical points in its establishment (from ages 7.5-10.5) in nonimpaired (Nl) and reading disabled (RD) cohorts. Our previous cross sectional research has identified reading gro National Institutes of Health 7/30/2010
YALE UNIVERSITY $111,502 Trans-NIH Recovery Act Research Support Regulated proteolysis is used to drive many biological processes, including the cell cycle, cell death, and embryonic patterning. It is also thought to mediate complex brain functions such as learning and memory. Not surprisingly, then, defects in regulat National Institutes of Health 1/21/2010
YALE UNIVERSITY $111,120 Trans-NIH Recovery Act Research Support The gap between basic research advances and new clinical insights and treatments remains a critical obstacle to progress in the field of alcoholism research. This translational neuroscience mission is the enduring focus of the Center for the Translational National Institutes of Health 8/20/2010
YALE UNIVERSITY $110,036 Trans-NIH Recovery Act Research Support Evidence from different disciplines suggests that acute and chronic stress-related mechanisms play an important role in the development of and the chronic, relapsing nature of addiction. These brain stress systems, including the central and peripheral cat National Institutes of Health 9/24/2009
YALE UNIVERSITY $108,000 Trans-NIH Recovery Act Research Support Dr. Simen is a clinical psychiatrist with a Ph.D. degree in Neurobiology. His career goals are to become an independent investigator in the Aging field, with a focus on how genomic changes that occur with age influence risk for cognitive and behavioral di National Institutes of Health 9/18/2009
YALE UNIVERSITY $107,982 Trans-NIH Recovery Act Research Support Project Summary Naturally occurring sequences capable of forming H-DNA (triplexes) are found in the human genome as frequently as 1 in every 50,000 base pairs. These sequences are typically found in promoters and exons and are believed to be involved in National Institutes of Health 9/21/2009
YALE UNIVERSITY $105,620 Trans-NIH Recovery Act Research Support MicroRNAs (miRNAs) are an abundant family of endogenous approx 21nt small RNAs that repress gene expression post-transcriptionally. More than 4percent of the human genes encode for miRNAs and current estimates suggest that miRNAs could target more than 30 National Institutes of Health 2/12/2010
YALE UNIVERSITY $104,006 Trans-NIH Recovery Act Research Support Posttraumatic Stress Disorder (PTSD) among adolescents exposed to disasters is prevalent and increases health morbidity and mortality. Although PTSD is common among youth exposed to traumatic stressors, is not present among all exposed youth. Disaster-exp
This spending item is part of a $213,824 allocation. See details
National Institutes of Health 9/28/2010
YALE UNIVERSITY $100,124 Trans-NIH Recovery Act Research Support Neurons are the most polarized cells known. Regulated assembly and disassembly of actin filament and microtubule cytoskeletal proteins is fundamental to generation of neuronal polarity and regulation of neuronal growth. Recent developments in imaging tech National Institutes of Health 9/25/2009
YALE UNIVERSITY $100,000 Trans-NIH Recovery Act Research Support Our research program centers on achieving a comprehensive molecular understanding of human polycystic liver and kidney disease. Our goal is discovery novel paradigms for effective treatment of patients. We have taken an approach that begins with disease g National Institutes of Health 3/11/2010
YALE UNIVERSITY $100,000 Trans-NIH Recovery Act Research Support The goals of the parent grant are to determine the function(s) of P2Y receptors and downstream cytosolic Ca2+ signals in hepatic stellate cell (HSC) function. HSC are important mediators of liver fibrosis, but their regulation is only partially understood National Institutes of Health 9/01/2009
YALE UNIVERSITY $100,000 Trans-NIH Recovery Act Research Support Bile secretion is a major function of the liver which is frequently impaired in diseases of the liver resulting in the syndrome of cholestasis. The long term objectives of this grant application, funded continuously since 1973, have been to characterize t National Institutes of Health 9/03/2009
YALE UNIVERSITY $100,000 Trans-NIH Recovery Act Research Support My long range goal is to understand the mechanism of cytokinesis. We will pursue complementary cellular, biochemical and genetic strategies using the fission yeast Schizosaccharomyces pombe to address the following specific aims: Project 1. Dynamics of co National Institutes of Health 12/23/2009
YALE UNIVERSITY $100,000 Trans-NIH Recovery Act Research Support The proximal tubule reabsorbs low molecular weight protein (less than 70 kDa) that passes the glomerular filtration barrier by a mechanism that is largely dependent on the scavenger receptor megalin. In the healthy adult this amounts to as much as 0.6-5.0 National Institutes of Health 12/08/2009
YALE UNIVERSITY $100,000 Trans-NIH Recovery Act Research Support Neural crest stem cells are involved in human illnesses including tumors and craniofacial and heart malformations. They generate most of the cells of the peripheral nervous system, craniofacial bone and cartilage, cells of the outflow tract of the heart a National Institutes of Health 3/08/2010
YALE UNIVERSITY $100,000 Trans-NIH Recovery Act Research Support Hepatocyte apoptosis results in repair responses including hepatic stellate cell (HSC) chemotaxis, contraction and matrix remodeling. The signals from apoptotic hepatocytes which modulate these responses are poorly identified. The uric acid pathway (UAP) National Institutes of Health 9/01/2009
YALE UNIVERSITY $100,000 Trans-NIH Recovery Act Research Support This application is for funding of a study to characterize the human immune response before and after 2010-2011 influenza A/California/H1N1 seasonal vaccination by developing comprehensive immune profiles utilizing systems biology and bioinformatics appro
This spending item is part of a $3,496,853 allocation. See details
National Institutes of Health 7/12/2010
YALE UNIVERSITY $99,999 Trans-NIH Recovery Act Research Support The short-term deleterious effects of acute kidney injury (AKI) on morbidity and mortality are well-known from several epidemiological studies. However, the long-term sequelae of AKI have not been thoroughly explored. Although AKI has been widely consider National Institutes of Health 11/27/2009
YALE UNIVERSITY $99,998 Trans-NIH Recovery Act Research Support Cytosolic Ca2+ is a critical second messenger in virtually every type of cell. Ca2+ is novel relative to other messenger molecules because it regulates multiple processes simultaneously within an individual cell. The ongoing theme of this research project National Institutes of Health 9/04/2009
YALE UNIVERSITY $99,800 Trans-NIH Recovery Act Research Support The Yale PKD Center has established one of the most complete arrays of in vivo models of polycystic kidney disease available. Most of these in vivo models produce cysts by somatic second hit mutations. One of the challenges facing all Center investigator National Institutes of Health 8/11/2009
YALE UNIVERSITY $99,650 Trans-NIH Recovery Act Research Support The Na-K-Cl cotransporter (NKCC) is a plasma membrane transport protein that plays a central role in cellular homeostasis. In non-polarized cells including neurons the NKCC1 isoform is involved in regulation of intracellular chloride and cell volume, and National Institutes of Health 9/11/2009
YALE UNIVERSITY $99,000 Trans-NIH Recovery Act Research Support The overall aim of this proposal is the development of deoxynucleoside analogs for the treatment of cancer. This includes studies on the mechanism of action and resistance of novel nucleoside analogs as well as the exploration of novel strategies to use n National Institutes of Health 9/09/2009
YALE UNIVERSITY $98,792 Trans-NIH Recovery Act Research Support The Yale Biomedical Informatics Research Training Program is directed by Prof. Perry L. Miller and is based n the Yale Center for Medical Informatics (YCMI) and many other academic units at Yale, reflecting the diversity of Yale's collaborative Biomedical National Institutes of Health 7/23/2009
YALE UNIVERSITY $98,712 Trans-NIH Recovery Act Research Support The long-term goal of this project is to understand the molecular mechanism by which cells acquire the essential trace metal copper. Towards this goal, we propose an integrated approach that combines electron crystallography, scanning mutagenesis, and bio National Institutes of Health 9/25/2009
HASKINS LABORATORIES, INC. $97,940 Trans-NIH Recovery Act Research Support Administrative Supplement for Equipment National Institutes of Health 7/17/2009
YALE UNIVERSITY $97,684 Trans-NIH Recovery Act Research Support Coxiella burnetii is a Gram-negative, obligate intracellular bacterium that is the causative agent of Q-fever in humans and is further classified as a Class B select agent. After uptake by a host cell, C. burnetii subverts specific host cell processes and National Institutes of Health 6/04/2009
YALE UNIVERSITY $97,030 Trans-NIH Recovery Act Research Support The pathologic proteolytic activation of digestive zymogens (primarily proteases such as chymotrypsinogen) within pancreatic acinar cells is a key step in initiating acute pancreatitis. Our laboratory examines extracellular factors and intracellular mecha National Institutes of Health 9/04/2009
YALE UNIVERSITY $96,008 Trans-NIH Recovery Act Research Support The proposed study can make more efficient use of cancer genomic data by properly accounting for the clustering structure of gene expressions and selecting predictive cancer biomarkers. It can provide more insights into the genomic mechanisms of cancer oc
This spending item is part of a $173,605 allocation. See details
National Institutes of Health 7/22/2009
JOHN B. PIERCE LABORATORY, INC., THE $94,872 Trans-NIH Recovery Act Research Support The pattern of activity in the circuits of the brain and their experience-dependent changes underlie the processing of sensory information, perception, and motor control. Much has been learned about the anatomical wiring of brain circuits and about the pr
This spending item is part of a $240,162 allocation. See details
National Institutes of Health 9/24/2009
YALE UNIVERSITY $93,098 Trans-NIH Recovery Act Research Support Abstract The SenseLab suite of 8 interoperable databases is aimed at supporting our research on a model system for brain organization, the olfactory bulb, and at sharing these and related resources with the neuroscience and neuroinformatics communities. D National Institutes of Health 7/17/2009
YALE UNIVERSITY $92,513 To design and test a method of intervention that has the capacity to promote engagement and adherence to treatment, foster recovery and reduce or prevent disability in patients experiencing a first episode of schizophrenia and related psychotic disorders.
This spending item is part of a $16,872,951 allocation. See details
National Institutes of Health 7/13/2009
YALE UNIVERSITY $92,429 Trans-NIH Recovery Act Research Support We request funds to purchase multiple instruments that will increase the throughput capacity of the DNA Analysis Facility on Science Hill (DAFSH) at Yale University. Currently DAFSH is functioning as a medium-throughput, fee-for-service and non-profit Cor National Institutes of Health 5/04/2009
YALE UNIVERSITY $89,383 Trans-NIH Recovery Act Research Support Piwi/Argonaute (Ago) is the only known protein family with function in stem cell self-renewal highly conserved in both animal and plant kingdoms. These proteins also play key roles in germline development and RNAi/miRNA-mediated mechanisms. Our long term National Institutes of Health 7/30/2010
YALE UNIVERSITY $89,300 Trans-NIH Recovery Act Research Support Human disorders caused by neuronal ion channel dysfunction are a major source of pain, suffering, and economic hardship. Their amelioration can be greatly facilitated by understanding the normal in vivo physiological functions served by the large number o National Institutes of Health 7/15/2009
YALE UNIVERSITY $87,028 Trans-NIH Recovery Act Research Support Support is requested to continue what has proven to be a highly successful program for the training of predoctoral students at the interface of chemistry and biology. Over the past four years, this CBI training program has supported 20 graduate students, National Institutes of Health 8/03/2009
YALE UNIVERSITY $86,531 Trans-NIH Recovery Act Research Support There is now growing evidence that livestock may be involved in spread of community-associated Methicillin Resistant Staphylococcus aureus (CA-MRSA) recent studies from Europe and Canada report a new strain (ST 398) that maybe associated with pig farming. National Institutes of Health 7/22/2009
YALE UNIVERSITY $85,152 Trans-NIH Recovery Act Research Support The aims of the ENCODE (Encyclopedia of DNA Elements) and modENCODE (model organism ENCODE) projects are to apply high-throughput, cost-efficient approaches to generate a catalog of functional elements in the human, worm, and fly genomes, which will serve
This spending item is part of a $2,789,724 allocation. See details
National Institutes of Health 9/30/2009
YALE UNIVERSITY $84,298 Trans-NIH Recovery Act Research Support The goal of this project is to establish the zebrafish bipolar cells as a system for studying the molecules involved neurotransmitter release from ribbon-type retinal neurons. Zebrafish are an excellent vertebrate model for physiology and disease, conduci National Institutes of Health 9/23/2009
YALE UNIVERSITY $84,200 Trans-NIH Recovery Act Research Support The overall goal of this Program Project is to understand the mechanisms underlying renal fluid and electrolyte homeostasis and renal epithelial function in health and the processes that modulate these mechanisms in disease. A broad spectrum of techniques National Institutes of Health 11/20/2009
YALE UNIVERSITY $84,105 Trans-NIH Recovery Act Research Support The long term goals of this proposal are to elucidate the molecular mechanisms involved in normal and abnormal expression of the human erythrocyte membrane protein ankyrin. Ankyrin-1, an important component of the red cell membrane skeleton, is expressed National Institutes of Health 1/25/2010
YALE UNIVERSITY $83,998 Trans-NIH Recovery Act Research Support The recent resurgence of important infectious diseases has led to a need for K-12 school curricula that create a better understanding of disease transmission dynamics and their biological underpinnings. To produce these curricula, Lyme disease and West Ni National Institutes of Health 9/13/2010
WEST HAVEN COMMUNITY HOUSE ASSOCIATION, INCORPORATED, THE $83,645 ARRA - Head Start ARRA Cost of Living (COLA) and Quality Improvement Funding consistent with the provisions of Section 540(a)(5) of the Head Start Act. Administration for Children and Families 6/26/2009
TEAM INC $83,553 ARRA - Head Start ARRA COLA and Quality Improvement funding consistent with the provisions of Section 640(a)(5) of the Head Start Act. Administration for Children and Families 7/02/2009
YALE UNIVERSITY $82,750 Trans-NIH Recovery Act Research Support This Research Plan is submitted in response to the Notice of Availability of Recovery Act Funds for Administrative Supplements (NOT-OD-09-056), for the purpose of enhancing our role as a Genetic Research Center (GRC), in the larger NIDDK IBD Genetics Cons National Institutes of Health 9/28/2009
YALE UNIVERSITY $82,556 Trans-NIH Recovery Act Research Support Hepatitis C virus (HCV) is an RNA virus that chronically infects an estimated 120-170 million people worldwide, with up to 20% developing liver diseases such as cirrhosis and hepatocellular carcinoma. The ability of HCV to establish life-long infection at National Institutes of Health 6/04/2009
YALE UNIVERSITY $81,045 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): In adult, reproductively active females, there is a continued increase in prevalence and propagation of metabolic disorders, such as obesity and type II diabetes. Beyond the harmful effects of these disorders on the ad National Institutes of Health 3/11/2010
YALE UNIVERSITY $80,719 Trans-NIH Recovery Act Research Support The Fogarty International Clinical Research Scholars & Fellows Support Center @ Vanderbilt University G?? Association of American Medical Colleges (FICRS?F) requests an administrative increase for the Fogarty International Clinical Research Scholars Suppo
This spending item is part of a $3,000,000 allocation. See details
National Institutes of Health 6/20/2009
COMMUNITY DEVELOPMENT INSTITUTE HEAD START $80,414 ARRA - Head Start This award provides ARRA funds for Head Start Quality Improvement and Cost of Living Adjustments (COLA) in accordance with FY 2009 Funding guidance ACF-PI-HS-09-06. Head Start promotes the school readiness of low-income children through the provision of Administration for Children and Families 9/15/2009
YALE UNIVERSITY $78,408 Trans-NIH Recovery Act Research Support The long term goals of this project are to understand how misfolded RNAs are recognized and handled within cells and to investigate how RNA misfolding impacts cell function. Our focus is on the Ro autoantigen, an RNA-binding protein that is a major target National Institutes of Health 8/13/2009
CONNECTICUT STATE UNIVERSITY F $75,723 Trans-NIH Recovery Act Research Support The goal of this project is to test risk and resiliency pathways linking social determinants of health and child characteristics to young children's health. We will examine the role of four social determinants of health (i.e., social position, racism, seg
This spending item is part of a $1,035,964 allocation. See details
National Institutes of Health 9/30/2009
YALE UNIVERSITY $75,138 Trans-NIH Recovery Act Research Support Lyme disease is the most common vector borne disease in the United States. Although antibiotic therapy is clinically effective in treating the symptoms of Lyme disease for patients early in the course of disease, a significant number of patients who rece
This spending item is part of a $471,506 allocation. See details
National Institutes of Health 7/16/2009
YALE UNIVERSITY $74,475 Trans-NIH Recovery Act Research Support The goal of the collaborative research proposed here is to establish a proof-of-principle that will provide foundations for the development of such technique(s). The novelty of our approach is in the use of a laser beam to selectively activate the transc
This spending item is part of a $151,195 allocation. See details
National Institutes of Health 7/17/2009
YALE UNIVERSITY $74,390 Trans-NIH Recovery Act Research Support Recent advances in cell culture studies provide invaluable insights on how the endothelial lineage is modulated by diverse signaling pathways. However, the cellular and molecular mechanisms that regulate the initial specification of endothelial lineage wi National Institutes of Health 9/10/2011
AGENCY ON AGING OF SOUTH CENTRAL CONNECTICUT, INC. $72,945 Aging Home-Delivered Nutrition Services for States ARRA provided funding for Home-Delivered Nutrition Services. Established in 1978 under the Older Americans Act, the program provides meals to seniors who are homebound.
This spending item is part of a $381,912 allocation. See details
Administration on Aging 3/18/2009
YALE UNIVERSITY $72,277 Trans-NIH Recovery Act Research Support This proposal is for a Rare Cancer Genetics Registry (RCGR). The proposal is being submitted for Challenge Area: 07: Enhancing Clinical Trials and specific Challenge Topic: Rare Disease Genetic Patient Registry: 07-OD(ORDR)-102. We will develop a registry
This spending item is part of a $987,770 allocation. See details
National Institutes of Health 9/29/2009
Western Connecticut Area Agency On Aging Inc $71,418 Aging Home-Delivered Nutrition Services for States ARRA provided funding for Home-Delivered Nutrition Services. Established in 1978 under the Older Americans Act, the program provides meals to seniors who are homebound.
This spending item is part of a $381,912 allocation. See details
Administration on Aging 3/18/2009
YALE UNIVERSITY $69,909 Trans-NIH Recovery Act Research Support The general objective of this project is the functional and molecular characterization of the multiple members of the myosin (Myo) family of actin based molecular motors that are expressed in the intestinal epithelial cell (IEC). The supplement funds awar National Institutes of Health 8/31/2009
YALE UNIVERSITY $68,000 Trans-NIH Recovery Act Research Support Our goal is to understand the molecular mechanisms controlling assembly and disassembly of actin filaments during cellular locomotion and endocytosis in terms of the rates of specific reactions. We will use a combination of biochemical, genetic and cellul National Institutes of Health 12/23/2009
YALE UNIVERSITY $67,281 Trans-NIH Recovery Act Research Support We have created an allelic PTHrP-lacZ knockin mouse that provides a simple and sensitive reporter of PTHrP gene expression. The PTHrP-lacZ mouse demonstrates PTHrP gene expression in a wide variety of locations, including several that were previously unap National Institutes of Health 11/26/2009
YALE UNIVERSITY $65,980 Trans-NIH Recovery Act Research Support In order to understand the potential selective forces that control codon usage in a model eukaryote, Drosophila, we propose to develop a direct experimental approach that has the potential or elucidating at what stage the phenotypic differences among DNA National Institutes of Health 9/09/2009
YALE UNIVERSITY $62,266 Trans-NIH Recovery Act Research Support In this application we are requesting funds for 3 pieces of key equipment to achieve the goals of the specific Aim proposed in Treloar_5 R01 DC 007600-04_ACC 1) A Kodak imaging station to allow multimodal molecular imaging of gels blots and plates. Curren National Institutes of Health 7/17/2009
YALE UNIVERSITY $62,250 Trans-NIH Recovery Act Research Support Tfiis is a K99 to ROO transition application which seeks further support for studying the association of four opioid receptor genes (0PRM1, 0PRD1, 0PRK1, and 0PRL1) and four opioid peptide genes (POMC, PDYN, PENK, and PNOC) genes and substance dependence National Institutes of Health 9/17/2009
YALE UNIVERSITY $61,235 Trans-NIH Recovery Act Research Support To assess whether blood-borne lactate, a potential alternative (non-glucose) monocarboxylic acid brain fuel, can support neuronal function during acute hypoglycemia in a rat model of type-1 diabetes (antecedent recurrent insulin-induced hypoglycemia). Rec National Institutes of Health 9/28/2009
YALE UNIVERSITY $60,936 Trans-NIH Recovery Act Research Support This proposal combines behavioral, biochemical and molecular approaches to examine the neurobiological influence of leptin on relapse to cocaine-seeking. The interaction between leptin, a peripheral hormone produced in fat cells, and relapse of cocaine-se National Institutes of Health 5/14/2009
YALE UNIVERSITY $58,015 Trans-NIH Recovery Act Research Support The proposed supplement will fund a summer research experience for four local science educators from non-research-intensive colleges and universities in the New Haven, CT-area to work on a double-blind, placebo controlled trial to test the efficacy of nal National Institutes of Health 7/10/2009
YALE UNIVERSITY $54,000 Trans-NIH Recovery Act Research Support Olfactory receptors (ORs) are seven-transmembrane chemosensors which are responsible for the initial step of odorant detection in the olfactory epithelium. Recently, ORs have also been found to play a role in chemosensation in non-olfactory tissues. Howev National Institutes of Health 12/18/2009
YALE UNIVERSITY $54,000 Trans-NIH Recovery Act Research Support Recent progress in podocyte biology suggests that glomerular capsular cell, namely glomerular parietal cells have the potential to contribute to podocyte regeneration/renal repair after kidney development concludes. My results derived from projects suppor National Institutes of Health 9/25/2009
YALE UNIVERSITY $53,726 Trans-NIH Recovery Act Research Support In evaluating human research projects taking place in international settings, U.S. Institutional Review Boards (IRBs) acknowledge their limitations in the understanding of local culture and context. Yet they remain obligated to comply with the 45CFR46 reg National Institutes of Health 9/25/2010
YALE UNIVERSITY $53,421 Trans-NIH Recovery Act Research Support Continued support is requested for our investigation of integrin-filamin interactions and their roles in adhesion signaling and cell migration. Integrins are transmembrane receptors that support cell adhesion and migration. They play essential roles throu National Institutes of Health 9/30/2009
YALE UNIVERSITY $53,229 Trans-NIH Recovery Act Research Support The objective of the primary research protocol presented in the PI's parent K-24 renewal application (Complications of Cirrhosis) aimed at comparing the efficacy of a combination of vasoconstrictors (octreotide + midodrine) vs. standard intravenous albumi National Institutes of Health 7/20/2009
YALE UNIVERSITY $52,531 Trans-NIH Recovery Act Research Support Chronic liver disease is the 10th leading cause of death in the USA,but liver transplantation is available to only a select few patients. Therefore, non-surgical alternatives are urgently needed. Surprisingly, adult bone marrow contains cells capable of e National Institutes of Health 7/20/2009
Yale-New Haven Community Medical Group, Inc. $51,960 Trans-NIH Recovery Act Research Support Prediabetes, the transition phase between normal glucose tolerance and T2DM, is a crucial time for intervention as the progression to T2DM in children is more rapid than in adults. We have shown that 1 out of every 4-5 obese children seen in the Yale Pedi
This spending item is part of a $386,633 allocation. See details
National Institutes of Health 9/24/2009
YALE UNIVERSITY $51,396 Trans-NIH Recovery Act Research Support Both healthy and pathological aging entail some degree of cognitive and neural decline. Executive functions appear to be particularly affected by aging (Hasher and Zacks, 1988). Executive function has traditionally been associated most strongly with the p National Institutes of Health 7/21/2009
YALE UNIVERSITY $50,463 Trans-NIH Recovery Act Research Support ln 3-month paid research experiences, over two summers, 4 talented undergraduate engineering and computer science students will be recruited to contribute in a substantial way to the progress of sub-aims of my parent New lnnovator (DP2) Award; the DP2's m National Institutes of Health 8/03/2009
YALE UNIVERSITY $50,000 Trans-NIH Recovery Act Research Support The ability to develop immunological memory to infectious diseases is critical for health and survival. These proposed studies will help elucidate how memory functions in order to better understand natural immunity and improve vaccine design. National Institutes of Health 9/11/2009
YALE UNIVERSITY $50,000 Trans-NIH Recovery Act Research Support The majority of emerging infectious diseases that affect humans are zoonotic; diseases that are transmittable between animals and humans. The health of animals can be a sentinel for zoonotic diseases in humans. Unfortunately, most local and state health d National Institutes of Health 12/11/2009
YALE UNIVERSITY $50,000 Trans-NIH Recovery Act Research Support Memory B cells that differentiate into antigen presenting and antibody-producing cells are important for long-term immunity to natural antigens and vaccines and may play a key role mediating the clinical manifestations of autoimmune diseases. Memory B cel National Institutes of Health 8/09/2010
YALE UNIVERSITY $50,000 Trans-NIH Recovery Act Research Support I am a National Library of Medicine research postdoctoral fellow in the Department of Molecular Biophysics and Biochemistry at Yale University. With this training/research proposal, I am applying to the Career Development Award. I had degreed education in National Institutes of Health 9/03/2009
YALE UNIVERSITY $49,999 Trans-NIH Recovery Act Research Support During the present and previous grant periods, our laboratory has comprehensively investigated the patterns of RNA expression in normal resting and activated neutrophils. These studies revealed remarkably vigorous transcriptional activity in neutrophils,
This spending item is part of a $98,998 allocation. See details
National Institutes of Health 12/17/2009
YALE UNIVERSITY $49,125 Trans-NIH Recovery Act Research Support The pattern of activity in the circuits of the brain and their experience-dependent changes underlie the processing of sensory information, perception, and motor control. Much has been learned about the anatomical wiring of brain circuits and about the pr
This spending item is part of a $240,162 allocation. See details
National Institutes of Health 9/24/2009
YALE UNIVERSITY $48,639 Trans-NIH Recovery Act Research Support The goal of this project is to understand lymphoid organ development and function in ontogeny and inflammation. Accordingly, the parent grant has 4 specific aims: 1. Determine how HEVs and LVs are regulated in acute inflammation 2. Determine how HEVs an National Institutes of Health 1/20/2010
YALE UNIVERSITY $46,553 Trans-NIH Recovery Act Research Support Intramembrane proteolysis is an important and widespread biochemical mechanism in cell biology: many membrane proteins undergo intramembrane proteolysis to become activated for signal transduction, or to be converted to poorly soluble amyloidal peptides t National Institutes of Health 9/30/2010
YALE UNIVERSITY $45,312 Trans-NIH Recovery Act Research Support The purpose of this supplement is to accelerate the tempo of the parent grant while engaging 6 students, including 3 young adults in high school, college or trade school from the New Haven community that have backgrounds similar to that of our study parti National Institutes of Health 6/01/2009
YALE UNIVERSITY $43,892 Trans-NIH Recovery Act Research Support This Training Program was completely restructured in 2002 in response to the evolution of physiology in the post-genomic era. With the sequencing of the genomes of various organisms including the human, significant strides have been made towards understan National Institutes of Health 8/13/2009
YALE UNIVERSITY $42,430 Trans-NIH Recovery Act Research Support Efforts to be supported by the supplemental request will focus on measuring the effects of myosins V, VI and VII on allosteric actin filament bending dynamics. Cooperative binding to actin filaments, mediated through myosin-dependent long-range conformati National Institutes of Health 9/30/2009
YALE UNIVERSITY $42,000 Trans-NIH Recovery Act Research Support NIH Grant Number -- 3R21HG004764-02S1: DNA Transport and Sequencing through a Quadrupole Gate: This award provides funding from the National Institutes of Health (NIH). The purpose of this project is to develop a high speed device for sequencing a sing
This spending item is part of a $278,725 allocation. See details
National Institutes of Health 9/30/2009
GRIFFIN HOSPITAL INC, THE $42,000 Trans-NIH Recovery Act Research Support Osteoarthritis (OA), the most common form of arthritis, is a slowly progressive degenerative disease of joint cartilage that afflicts 40 million Americans. Existing pharmacologic therapies (acetaminophen, non- steroidal anti-inflammatories (NSAIDs), & COX
This spending item is part of a $1,410,313 allocation. See details
National Institutes of Health 6/29/2009
YALE UNIVERSITY $39,746 Trans-NIH Recovery Act Research Support In cystic fibrosis (CF), mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel are associated with defective cAMP and acid-stimulated duodenal bicarbonate secretion, and defective cAMP and cGMP-activated fluid secret National Institutes of Health 8/31/2009
YALE UNIVERSITY $39,541 Trans-NIH Recovery Act Research Support The overall goal of the proposed study is to investigate the role of cholesterol, including serum and islet cholesterol, in pancreatic (-cell dysfunction that characterizes the progression of type 2 diabetes. Alteration of pancreatic (-cell function leadi National Institutes of Health 12/26/2009
YALE UNIVERSITY $37,177 Trans-NIH Recovery Act Research Support Many studies have suggested a relationship between depression and cardiovascular disease (CVD), but its causal role in the etiology of CVD is still debated and the mechanisms are unclear. Rather than being causally related, depression and CVD could share
This spending item is part of a $1,544,566 allocation. See details
National Institutes of Health 8/17/2009
YALE UNIVERSITY $36,857 Trans-NIH Recovery Act Research Support Among the consequences of normal aging, one of the most distressing is decline in memory. The associated loss of productivity, physical health, and sense of well-being will create an increasing number of critical economic and public health issues as the U National Institutes of Health 9/18/2009
YALE UNIVERSITY $35,847 Trans-NIH Recovery Act Research Support Support is requested for three undergraduate students and a high school science teacher to participate in summer research projects on one of the principal themes of the parent grant, namely the role of SLC26A6 and related transporters in the integrative p National Institutes of Health 7/13/2009
YALE UNIVERSITY $35,766 Trans-NIH Recovery Act Research Support This application requests supplemental funds to enhance progress on the parent grant and to encourage students to pursue careers in health-related sciences. We have found that chronic stimulation through NOD2 in primary peripheral monocyte-derived human National Institutes of Health 7/16/2009
YALE UNIVERSITY $35,583 Trans-NIH Recovery Act Research Support Implanting human cytotrophoblasts (CTBs) invade an underlying decidua comprised of decidual cells and such immune cells as macrophages (MFs) and dendritic cells (DCs). These specialized antigen-presenting cells (APCs) mediate innate immunity, subsequent a National Institutes of Health 6/15/2010
YALE UNIVERSITY $35,583 Trans-NIH Recovery Act Research Support Implanting human cytotrophoblasts (CTBs) invade an underlying decidua comprised of decidual cells and such immune cells as macrophages (Mac) and dendritic cells (DCs). These specialized antigen-presenting cells (APCs) mediate innate immunity, subsequent a National Institutes of Health 6/02/2009
YALE UNIVERSITY $34,781 Trans-NIH Recovery Act Research Support The pathologic proteolytic activation of digestive zymogens (primarily proteases such as chymotrypsinogen) within pancreatic acinar cells is a key step in initiating acute pancreatitis. Our laboratory examines extracellular factors and intracellular mecha National Institutes of Health 6/22/2009
YALE UNIVERSITY $34,188 Trans-NIH Recovery Act Research Support Project Narrative Herpes simplex virus-2 (HSV-2), a causative agent of genital herpes, is a highly prevalent (45 million in the USA alone) sexually transmitted infection. Once acquired, HSV-2 causes a life-long incurable debilitating disease for which no National Institutes of Health 9/11/2009
YALE UNIVERSITY $34,077 Trans-NIH Recovery Act Research Support Tourette's Syndrome (TS) is a childhood-onset neuropsychiatric illness characterized by motor and vocal tics. The cerebral cortex-basal ganglia circuitry regulates motor habits and goal-directed behavior. A question still unanswered is whether there are c National Institutes of Health 9/15/2009
YALE UNIVERSITY $31,445 Trans-NIH Recovery Act Research Support Data from our laboratory has shown that gamma-amino butyric acid (GABA) inhibitory tone within a crucial glucose sensing region of the brain, the ventromedial hypothalamus (VMH), plays an important role in modulating the magnitude of glucose counter regul National Institutes of Health 8/04/2009
YALE UNIVERSITY $30,942 Trans-NIH Recovery Act Research Support Human African trypanosomiasis (HAT) kills thousands of people each year in sub-Saharan Africa. The disease is caused by African trypanosomes transmitted by the tsetse fly.HAT transmission is complex; it requires mammalian and invertebrate hosts and involv National Institutes of Health 5/24/2010
YALE UNIVERSITY $30,678 Trans-NIH Recovery Act Research Support Abstract Recent increases in HIV diagnoses, sexually transmitted infections, and risk behavior indicate that research is needed to identify effective positive prevention interventions integrated within HIV primary care settings to reduce transmission ris
This spending item is part of a $1,439,593 allocation. See details
National Institutes of Health 6/08/2009
YALE UNIVERSITY $30,555 Trans-NIH Recovery Act Research Support Several lines of evidence suggest amino acid neurotransmitter system abnormalities contribute to the neurobiology of depression. In humans, there is clear evidence of altered amino acid neurotransmitter function in depressed individuals. Most notably, dep
This spending item is part of a $135,494 allocation. See details
National Institutes of Health 7/16/2009
YALE UNIVERSITY $26,045 Trans-NIH Recovery Act Research Support The lateral hypothalamus (LH) serves as a central hub, integrating a wide range of inputs from various brain regions and projecting neuropeptide-containing nerve fibers all over the brain. The LH has long been recognized as a feeding center. The regulatio National Institutes of Health 12/18/2009
YALE UNIVERSITY $21,323 Trans-NIH Recovery Act Research Support The project will create and pilot an intensive, eight session, group cessation intervention designed to address the needs and concerns of smokers living with HIV/AIDS. It will be guided by the social cognitive theory model, the groups will be led by paire
This spending item is part of a $400,377 allocation. See details
National Institutes of Health 5/14/2009
YALE UNIVERSITY $16,375 Trans-NIH Recovery Act Research Support This proposal requests supplemental funds to enhance and accelerate progress on the parent grant, IBD Genetics Consortium Data Coordinating Center (U01 DK62429). The Data Coordinating Center (DCC) is jointly operated between Yale University and the Univer
This spending item is part of a $394,000 allocation. See details
National Institutes of Health 9/29/2009