Recovery Tracker

How Much Stimulus Funding is Going to Your County?

Durham County, N.C., funds by Health and Human Services, Department of

Listing $254,921,335.14 in stimulus funds from Health and Human Services, Department of for Durham

Note: For some programs where states do not report where money will be distributed across the state, we do not have the allocation for individual counties. Those programs include: Medicaid, unemployment benefits and food stamps. Those amounts are included in the totals for where the state agency receiving that money is located.

Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.

Recipient Amount Description Federal Dept./Agency Date
DUKE UNIVERSITY $14,916,552 National Center for Research Resources, Recovery Act Construction Support Duke researchers whose current or past investigations have required significant use of USDA-covered species are responsible for $20,407,773 in annual direct costs from the National Institutes of Health. Strength of these progra... Show more National Institutes of Health 3/04/2010
DUKE UNIVERSITY $13,529,199 Trans-NIH Recovery Act Research Support Millions of Americans develop chest pain suggestive of coronary heart disease each year and often require non-invasive diagnostic testing. However, currently available tests are imprecise, robust evidence regarding optimal test choice is limited, and test
This spending item is part of a $13,613,141 allocation. See details
National Institutes of Health 9/29/2009
DUKE UNIVERSITY $6,000,000 This proposal to AHRQ from the Duke Evidence-Based Practice Center (EPC) is in response to the ''ARRA 2009 - Comprehensive EPC Comparative Effectiveness Reviews for Effective Health Care' request for task order. Awarding of this Task Order would allow the Agency for Healthcare Research and Quality 10/26/2009
RESEARCH TRIANGLE INSTITUTE $5,984,293 RTI will provide support to the Office of the National Coordinator for Health Information Technology (ONC) to plan, coordinate, and facilitate meetings at the national and regional levels for the Health Information Technology Research Center (HITRC) in it Agency for Healthcare Research and Quality 3/31/2010
RESEARCH TRIANGLE INSTITUTE $4,999,899 The purpose of this contract is to support selected State Consortiums in the development and implementation of solutions to privacy and security issues preventing or impeding the interstate exchange of health information. Program Support Center 3/31/2010
DUKE UNIVERSITY $4,595,669 Trans-NIH Recovery Act Research Support This proposal is the first step in a major paradigm shift leading to global acceptance of evidence-based protocol-driven care as the optimal approach to treatment of pediatric rheumatic diseases by families, patients, and health care providers. Through th
This spending item is part of a $6,824,989 allocation. See details
National Institutes of Health 9/30/2009
DUKE UNIVERSITY $4,213,882 National Center for Research Resources, Recovery Act Construction Support The long-term objective of the proposed project is to create a unique, state-of-the-art facility for bioengineering and biomedical research within the Fitzpatrick Center for Interdisciplinary Engineering, Medicine and Applied S... Show more National Institutes of Health 9/14/2009
DUKE UNIVERSITY $3,996,278 Trans-NIH Recovery Act Research Support Vexing questions in the field of genomic biomarkers are: How do we build the evidence to support their clinical use? And what is their clinical value? The objective of this proposal is to develop an innovative framework for clinical effectiveness research National Institutes of Health 9/29/2009
RESEARCH TRIANGLE INSTITUTE $3,900,986 ICF Macro was awarded a contract to support multiple evaluation components of the Communities Putting Prevention to Work (CPPW) initative in communities and state. These multiple components will emply both quantitative and qualitative evaluation methods.
This spending item is part of a $11,696,162 allocation. See details
Centers for Disease Control and Prevention 9/09/2010
RESEARCH TRIANGLE INSTITUTE $3,606,822 The purpose of this project is to assist the Office of the National Coordinatorfor Health IT (ONC), the Health Information Technology Research Center (HITRC), and the current 60 Regional Exchange Centers (RECs) with identifying and developing 'best practi Agency for Healthcare Research and Quality 3/31/2010
DURHAM'S PARTNERSHIP FOR CHILDREN $3,425,970 ARRA - Early Head Start The Durham Early Head Start (DEHS) program will provide full, comprehensive services to 120 infants and toddlers (0-3) and English and Spanish-speaking pregnant women via two modalities: Center-based: full-year, full-day program at partnering licensed c Administration for Children and Families 12/04/2009
DUKE UNIVERSITY $3,198,204 Trans-NIH Recovery Act Research Support This Grand Opportunity (RC2) grant is written in response to NHLBI call for proposals on Large-scale DNA Sequencing and Molecular Profiling of Well-phenotyped NHLBI Cohorts and the addendum portion describing Molecular Profiling. The identification of mol National Institutes of Health 9/28/2009
DUKE UNIVERSITY $3,102,008 Trans-NIH Recovery Act Research Support RFA-OD-09-004 Recovery Act Limited Competition for NIH Grants: Research and Research Infrastructure G?Grand OpportunitiesG? (RC2) Large-scale genetics studies on schizophrenia to date have failed to discover a substantial contribution of common genetic va
This spending item is part of a $3,132,972 allocation. See details
National Institutes of Health 9/30/2009
RESEARCH TRIANGLE INSTITUTE $3,042,659 The purpose of this task order is to conduct evaluation case studies for purposes of identifying patterns in effective implementation of evidence-based prevention strategies. Significant deliverables include: - Analysis Plan, - OMB Package, - Site Visit Centers for Disease Control and Prevention 7/16/2010
RESEARCH TRIANGLE INSTITUTE $3,000,000 The RTI International-University of North Carolina at Chapel Hill Evidence-based Practice Center (RTI-UNC EPC) conducts four major types of comparative effectiveness activities for AHRQ, with a special focus on mental health. Area 1 includes the developme
This spending item is part of a $6,000,000 allocation. See details
Agency for Healthcare Research and Quality 10/23/2009
DUKE UNIVERSITY $2,709,326 Trans-NIH Recovery Act Research Support Palliative care, a relatively new subspecialty, needs to build its evidence base supporting clinical practice. The Institute of Medicine has identified palliative care as a comparative effectiveness research priority, but increased scientific productivity
This spending item is part of a $7,175,320 allocation. See details
National Institutes of Health 9/30/2010
DUKE UNIVERSITY $2,552,732 Trans-NIH Recovery Act Research Support The fundamental roles of innate and adaptive host responses are to recognize and eradicate invading antigens, pathogens or altered self components with the purpose of restoring tissue integrity and homeostasis. While resolution can occur when the host re
This spending item is part of a $2,941,248 allocation. See details
National Institutes of Health 9/11/2009
DURHAM, COUNTY OF $2,535,384 ARRA Child Care and Development Block Grant ARRA Supplemental Funding for the Child Care and Development Fund (CCDF): Provide child care financial assistance to low-income working families and fund activities to support the quality of child care. Child care subsidy funds were used to fund direct
This spending item is part of a $67,543,134 allocation. See details
Administration for Children and Families 4/09/2009
RESEARCH TRIANGLE INSTITUTE $2,499,436 The mission of the Substance Abuse and Mental Health Services Administration (SAMHSA) is to reduce the impact of substance abuse and mental illness on America's communities. Conducted on a periodic basis from 1971-1988, and annually since 1990, the Natio Substance Abuse and Mental Health Services Administration 9/30/2010
RESEARCH TRIANGLE INSTITUTE $2,449,667 The purpose of this task order is to compare the effectiveness of traditional evidence-based tobacco cessation interventions to newer and innovative interventions used by Comprehensive Cancer Control (CCC) Programs across several states. Centers for Disease Control and Prevention 7/16/2010
DUKE UNIVERSITY $2,433,915 Trans-NIH Recovery Act Research Support We propose an interdisciplinary CER KM1 training program, focused on Biostatistics, Cancer, and Cardiology that matches mentors from diverse CER methodological backgrounds with mentees committed to a career in CER. A leadership team of experienced Duke CE National Institutes of Health 9/28/2010
RESEARCH TRIANGLE INSTITUTE $2,293,037 RTI will develop an authoritative Nanomaterial Registry to provide consistent and curated information on the biological and environmental interactions of well-characterized nanomaterials.
This spending item is part of a $2,899,367 allocation. See details
National Institutes of Health 7/02/2010
DUKE UNIVERSITY $2,202,608 Trans-NIH Recovery Act Research Support Millions of Americans develop chest pain suggestive of coronary heart disease each year and often require non-invasive diagnostic testing. However, currently available tests are imprecise, robust evidence regarding optimal test choice is limited, and test National Institutes of Health 9/29/2009
DUKE UNIVERSITY $2,187,874 Trans-NIH Recovery Act Research Support Psychostimulant (methamphetamine [METH] and cocaine) abuse has reached an epidemic proportion in the US and worldwide, presenting profound socioeconomic, legal and medical problems. In addition, it is a significant comorbid factor for other psychiatric di National Institutes of Health 9/30/2009
RESEARCH TRIANGLE INSTITUTE $2,180,731 As part of the Health Information Technology Research Center (HITRC), RTI International will identify, develop, and disseminate educational tools and resources to assist 60 to 70 regional extension centers (RECs) nationwide work with providers in their co Agency for Healthcare Research and Quality 3/31/2010
DUKE UNIVERSITY $2,162,731 Trans-NIH Recovery Act Research Support Full Human Genome Sequencing in ALS - The causes of most neurodegenerative disorders (ALS, Alzheimer and Parkinson disease) are poorly understood, despite remarkable advances in delineating the molecular pathology in the rare forms of these diseases that
This spending item is part of a $3,608,339 allocation. See details
National Institutes of Health 9/25/2009
DUKE UNIVERSITY $2,118,330 Trans-NIH Recovery Act Research Support .Abstract G?Metabolomics Network for Drug Response PhenotypeG? Response to Recovery Act Limited Competition for NIH Grants: Research and Research Infrastructure G?Grand OpportunitiesG? (RC2), RFAOD- 09-004-Linking Metabolomics to Pharmacogenomics Cardiova
This spending item is part of a $4,507,931 allocation. See details
National Institutes of Health 9/30/2009
DUKE UNIVERSITY $1,964,256 Poor outcomes are common for heart failure (HF) patients with 1-year readmission rates over 50% and 1-year mortality greater than 30% among Medicare Beneficiaries hospitalized with heart failure.} Heart failure is also the top diagnosis for hospitalizatio
This spending item is part of a $2,073,232 allocation. See details
Agency for Healthcare Research and Quality 7/13/2010
DUKE UNIVERSITY $1,950,066 Recovery Act Comparative Effectiveness Research - AHRQ Duke University Medical Center (DUMC) proposes a Mentored Comparative Effectiveness Research Scholar Program (MCERSP) in response to the AHRQ ARRA Recovery Act 2009 Limited Competition RFA-HS-10-007. For over 30 years, Duke has been a world leade... Show more Agency for Healthcare Research and Quality 9/15/2010
DUKE UNIVERSITY $1,878,670 Trans-NIH Recovery Act Research Support The need for a more efficient and effective infrastructure for clinical research has been articulated by ARRA, as well as by the NIH clinical roadmap initiative. One of the greatest national inefficiencies of the current model of clinical research is the
This spending item is part of a $2,630,773 allocation. See details
National Institutes of Health 9/29/2009
DUKE UNIVERSITY $1,845,644 Trans-NIH Recovery Act Research Support Heavy habitual consumption of alcohol leads to progressive injury and fibrosis in several tissues, including the liver. However, many heavy drinkers do not develop advanced liver fibrosis (i.e., cirrhosis) despite years of alcohol abuse. More modest consu
This spending item is part of a $1,975,573 allocation. See details
National Institutes of Health 9/30/2009
RESEARCH TRIANGLE INSTITUTE $1,771,284 The mission of the Substance Abuse and Mental Health Services Administration (SAMHSA) is to reduce the impact of substance abuse and mental illness on America's communities. Conducted on a periodic basis from 1971-1988, and annually since 1990, the Natio
This spending item is part of a $2,500,562 allocation. See details
Substance Abuse and Mental Health Services Administration 7/16/2010
RESEARCH TRIANGLE INSTITUTE $1,726,416 This three year (with one option year) contract was awarded to provide technical assistance to CMS on the EHR incentive program. The techincal assistance consists of two separate activities. First, RTI will conduct data analyses on the functional measure Health Care Financing Admin. (was Medicare and Medicaid Serv.) 9/26/2011
DUKE UNIVERSITY $1,551,891 ARRA Accelerating Adoption of Comparative Effectiveness Research (CER) We know from existing comparative effectiveness research that certain feeding practices and therapeutics result in overall harm to preterm infants. We have shown that a large number of preterm infants are currently exposed to thes... Show more
This spending item is part of a $2,841,474 allocation. See details
Office of Assistant Secretary for Planning and Evaluation 9/20/2010
DUKE UNIVERSITY $1,534,052 Trans-NIH Recovery Act Research Support Making HIV testing routine is one of the major HIV prevention strategies in the United States. The Centers for Disease Control and Prevention recently recommended that prevention counseling not be required as part of HIV screening programs in medical care
This spending item is part of a $12,292,823 allocation. See details
National Institutes of Health 9/28/2009
DUKE UNIVERSITY $1,518,013 Trans-NIH Recovery Act Research Support Colorectal cancer is the third most common cancer and the second leading cause of cancer related death in the United States. 75% of patients diagnosed with colorectal cancer will have early stage disease and despite surgical resection for curative intent, National Institutes of Health 9/29/2009
DUKE UNIVERSITY $1,513,285 Trans-NIH Recovery Act Research Support Coronary artery disease (CAD) is the leading cause of the death in the US and, in concert with the epidemic of obesity and diabetes, is becoming the leading cause of death in many developing countries. The genetic predilection of CAD is well-established. National Institutes of Health 7/16/2009
DUKE UNIVERSITY $1,473,447 Trans-NIH Recovery Act Research Support This application is in response to RFA-OD-09-004, 'GO' grants program area: ARRA Medical Sequencing Discovery Projects. Despite clear evidence for the importance of genetics in susceptibility to epilepsy, only limited progress has been made in identifying
This spending item is part of a $2,000,025 allocation. See details
National Institutes of Health 9/25/2009
DUKE UNIVERSITY $1,430,176 Trans-NIH Recovery Act Research Support The long-term goal of this research project is to improve the efficacy of anti-nicotine vaccination/immunotherapy for smoking cessation. The proposal relates to the special interest of NIDA in RFAOD- 09-004: G?Nicotine and Tobacco ResearchG? and addresses
This spending item is part of a $2,583,504 allocation. See details
National Institutes of Health 9/30/2009
DUKE UNIVERSITY $1,378,000 Trans-NIH Recovery Act Research Support The nascent interdisciplinary field of Neuroeconomics harnesses the computational rigor of economics and the technological advances of modern biology to advance discovery in the decision sciences. Since pathologies of decision making are endemic to addict National Institutes of Health 9/30/2009
RESEARCH TRIANGLE INSTITUTE $1,362,051 Under the direction of the U.S. Centers for Disease Control and Prevention, RTI International will refine, calibrate, validate and apply computer models to assess and forecast the effectiveness of strategies adopted as part of Communities Putting Preventi Centers for Disease Control and Prevention 5/17/2010
DUKE UNIVERSITY $1,302,120 ARRA - Health Information Technology Professionals in Health Care Project Title:Consortia for University-based Training of Health IT Professionals in Health Care. Duke University and University of North Carolina at Chapel Hill (UNC) are partnering on this University-based Training Grant. Our near te... Show more
This spending item is part of a $2,167,121 allocation. See details
Health and Human Services, Department of 4/02/2010
LINCOLN COMMUNITY HEALTH CENTER, INCORPORATED $1,300,770 ARRA Health Center Integrated Services Development Initiative[g1] The ARRA Capital Improvement Program (CIP) grant award provided the opportunity to renovate the 6,848 square feet patient care area at the main site of Lincoln Community Health Center. The project included the upgrade of the radiology ... Show more Health Resources and Services Administration 6/25/2009
DUKE UNIVERSITY $1,272,879 Trans-NIH Recovery Act Research Support DESCRIPTION: Fumonisin (FB1) is a mycotoxin produced by a common fungal contaminant of corn (maize) . An association has recently been observed between ingestion of FB1-contaminated maize during early pregnancy and increased risk for having a child with a
This spending item is part of a $2,715,666 allocation. See details
National Institutes of Health 9/24/2010
DUKE UNIVERSITY $1,244,977 Trans-NIH Recovery Act Research Support Few studies have examined the relationship with gene on the DNA repair and apoptosis pathways. Our preliminary data support associations with several single nucleotide polymorphism in genes in these pathways but a larger sample size is needed to confirm t
This spending item is part of a $1,563,767 allocation. See details
National Institutes of Health 8/04/2009
RESEARCH TRIANGLE INSTITUTE $1,210,112 The purpose of this task order is to collect and analyze data related to the direct costs incurred by community activities funded under the Communities Putting Prevention to Work (CPPW) Initiative. The CPPW Initiative has funded 44 communities and states Program Support Center 6/17/2010
RESEARCH TRIANGLE INSTITUTE $1,205,694 Trans-NIH Recovery Act Research Support The project is providing support for 10 jobs at RTI international (1 full time 9 part-time), 2 part-time jobs at UNC Chapel Hill, and 2 part-time consultants from Yale University. In particular the project supports In this methodological study we will d
This spending item is part of a $1,494,669 allocation. See details
National Institutes of Health 9/30/2010
DUKE UNIVERSITY $1,094,922 Trans-NIH Recovery Act Research Support Abstract Recent increases in HIV diagnoses, sexually transmitted infections, and risk behavior indicate that research is needed to identify effective positive prevention interventions integrated within HIV primary care settings to reduce transmission ris
This spending item is part of a $1,439,593 allocation. See details
National Institutes of Health 6/08/2009
GLOBAL VACCINES INC $1,069,641 Trans-NIH Recovery Act Research Support The impportance of the innate immune response as both the first line of defense against infection and a powerful trigger of adaptive immunity, and the definition of signaling pathways involved with this response, have led to intense testing of individual National Institutes of Health 8/28/2009
DUKE UNIVERSITY $1,016,785 Trans-NIH Recovery Act Research Support This proposal responds to the (09) Health Disparities broad challenge area and the specific challenge topic: Building Trust Between Researchers and Communities Through Capacity Building in Environmental Public Health (09-ES-101*). African Americans have t National Institutes of Health 9/28/2009
DUKE UNIVERSITY $999,860 Trans-NIH Recovery Act Research Support Millions of individuals world-wide use aspirin for cardioprotection yet clinicians currently lack a reliable tool to accurately identify those patients who will develop myocardial infarction (MI) or stroke despite aspirin use. Our long-term goal is to per National Institutes of Health 9/28/2009
DUKE UNIVERSITY $998,996 Trans-NIH Recovery Act Research Support Three major trends in medicine offer a tremendous opportunity for Duke University and Durham County, NC to develop a model for population health that will provide insights applicable to the CTSA program and to create a novel, sustainable source of jobs fo National Institutes of Health 8/13/2009
RESEARCH TRIANGLE INSTITUTE $998,978 This project, funded by the U.S. Agency for Healthcare Research and Quality (AHRQ), will improve methods for assessing and synthesizing evidence about the quality and efficacy of health care services. It will also promote use of these methods by AHRQ Evi Agency for Healthcare Research and Quality 9/25/2009
RESEARCH TRIANGLE INSTITUTE $998,978 This project, funded by the U.S. Agency for Healthcare Research and Quality (AHRQ), will improve methods for assessing and synthesizing evidence about the quality and efficacy of health care services. It will also promote use of these methods by AHRQ Evi Agency for Healthcare Research and Quality 9/25/2009
RESEARCH TRIANGLE INSTITUTE $998,978 This project, funded by the U.S. Agency for Healthcare Research and Quality (AHRQ), will improve methods for assessing and synthesizing evidence about the quality and efficacy of health care services. It will also promote use of these methods by AHRQ Evi Agency for Healthcare Research and Quality 9/25/2009
DUKE UNIVERSITY $998,487 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic, 06-HD-101 Improved interfaces for prostheses to improve rehabilitation outcomes. Considerable progress has been made during the last decade in the dev National Institutes of Health 9/29/2009
DUKE UNIVERSITY $998,459 Trans-NIH Recovery Act Research Support 'This application addresses broad Challenge Area Biomarker Discovery and Validation (03) and specific Challenge Topic Imaging Biomarkers (03-AR-104) We desire to detect important biomarkers associated with the onset of skin cancers, with a particular emph National Institutes of Health 9/29/2009
DUKE UNIVERSITY $996,472 Trans-NIH Recovery Act Research Support This application addresses Broad Challenge Area (03) Biomarker, Discovery and Validation, with specific Challenge Topic, 03-MH-101, Biomarkers in Mental Disorders. We propose to leverage an ongoing collaboration among faculty from several disciplines to i National Institutes of Health 9/29/2009
DUKE UNIVERSITY $992,651 Trans-NIH Recovery Act Research Support (03) Biomarker Discovery and Validation general challenge Area and the 03-MH-101 Biomarkers in mental disorders specific challenge topic. Anorexia nervosa (AN) is a terrifying and perplexing disorder. Eating disorders, in general, rank among the top ten c National Institutes of Health 9/25/2009
DUKE UNIVERSITY $977,459 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic 04-AI- 102: The human immune response to infection and immunization - Profiling via modern immunological methods and systems biology. The ability to monito National Institutes of Health 9/23/2009
DUKE UNIVERSITY $963,318 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic, 15- HL-101: Develop improved biocompatible surfaces for implantable blood-contacting medical devices. More than five million Americans, and increasing
This spending item is part of a $990,260 allocation. See details
National Institutes of Health 9/21/2009
RESEARCH TRIANGLE INSTITUTE $962,616 RTI is to create a public query tool (application) to enhance the research capability of the the NIDDK data repository, and will modify the NIDDK CDR portal . National Institutes of Health 3/08/2010
RESEARCH TRIANGLE INSTITUTE $955,027 Trans-NIH Recovery Act Research Support Similar to dopamine, glutamate regulation of the reward circuitry involves inputs to the ventral tegmental area and the nucleus accumbens. Functional dysregulation of the circuits has been proposed as neural substrates of drug dependence. Since neuroadapt National Institutes of Health 8/01/2009
DUKE UNIVERSITY $916,378 Trans-NIH Recovery Act Research Support Newborn screening with tandem mass spectrometry (MS/MS) has been expanded to detect a number of inherited disorders of metabolism, including lysosomal storage disorders. MS/MS allows the pre-symptomatic detection and early treatment of infants with inheri National Institutes of Health 8/07/2009
DUKE UNIVERSITY $913,698 Trans-NIH Recovery Act Research Support This is an application for support from the Recovery Act Limited Competition for NIH Grants: Research to Address the Heterogeneity in Autism Spectrum Disorders (R01) RFA-MH-09-170. We propose to leverage ongoing collaboration among faculty at Duke Univers
This spending item is part of a $1,616,415 allocation. See details
National Institutes of Health 9/30/2009
DUKE UNIVERSITY $889,200 Trans-NIH Recovery Act Research Support Neuroendocrine or immune events occurring within the perinatal environment often produce effects on brain and behavior that endure throughout an organism's life span. An estimated 1/3 of pregnancies suffer complications involving infection or trauma of th National Institutes of Health 6/08/2009
RESEARCH TRIANGLE INSTITUTE $872,224 Trans-NIH Recovery Act Research Support This supplemental funding will extend and enhance communication, coordination and outreach efforts under way to develop a set of consensus standard measures used in genetic/genomic research to describe various phenotypes and exposures (the PhenX project). National Institutes of Health 7/30/2009
RESEARCH TRIANGLE INSTITUTE $872,224 Trans-NIH Recovery Act Research Support This supplemental funding will extend and enhance communication, coordination and outreach efforts under way to develop a set of consensus standard measures used in genetic/genomic research to describe various phenotypes and exposures (the PhenX project). National Institutes of Health 7/30/2009
DUKE UNIVERSITY $852,821 Trans-NIH Recovery Act Research Support This is a combined project led by the American College of Cardiology (ACCF) and The Society of Thoracic Surgeons (STS) to compare two procedures to treat coronary artery disease (CAD), percutaneous coronary intervention (PCI) and coronary artery bypass gr
This spending item is part of a $4,026,764 allocation. See details
National Institutes of Health 9/29/2009
DUKE UNIVERSITY $843,464 Trans-NIH Recovery Act Research Support The Duke Center for In Vivo Microscopy (CIVM) is an NCRR National Resource, now in our 19th year dedicated to the development of novel methods for small animal imaging and the application of those methods to important biomedical questions. We propose acce
This spending item is part of a $904,747 allocation. See details
National Institutes of Health 9/17/2009
OPERATION BREAKTHROUGH, INC. $825,512 ARRA - Community Services Block Grant North Carolina's ARRA Supplemental Funding for the Community Services Block Grant (CSBG) Program funds were allocated to a network of eligible organizations (Community Action Agencies) to support employment related services that primarily created and sust
This spending item is part of a $26,243,124 allocation. See details
Administration for Children and Families 4/10/2009
DUKE UNIVERSITY $823,873 Recovery Act Comparative Effectiveness Research - AHRQ DESCRIPTION (provided by applicant): The proposed Comparative Effectiveness Research (CER) Fellowship will provide both didactic and practical training in health services research for both MD and PhD post-doctoral fellows. The faculty, MD and PhD... Show more Agency for Healthcare Research and Quality 7/01/2010
DUKE UNIVERSITY $819,998 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (08) Genomics and specific Challenge Topic, 08- AG-101: Genetic factors affecting rates of change in disease risk factors with age. Alzheimer's disease (AD) is the most critical unmet need in neurological me National Institutes of Health 9/24/2009
DUKE UNIVERSITY $816,679 Trans-NIH Recovery Act Research Support The therapeutic utility of inhibiting/modulating progesterone receptor (PR) transcriptional activity in uterine fibroids has been well validated both in preclinical models of this disease and in several definitive clinical studies. Indeed, both antiproges National Institutes of Health 7/28/2009
DUKE UNIVERSITY $811,739 Trans-NIH Recovery Act Research Support Five million patients suffer from heart failure in the United States. Clinical trials of stem cell therapy, initiated because of the severity of this problem, have yielded modest results. Understanding the epigenetic programs that induce differentiation o
This spending item is part of a $1,273,672 allocation. See details
National Institutes of Health 7/16/2009
DUKE UNIVERSITY $783,292 Trans-NIH Recovery Act Research Support This proposal, entitled ICD Therapy in Patients with Congestive Heart Failure, examines the current use of primary prevention implantable cardioverter defibrillator (ICD) in clinical practice. Although randomized clinical trials have established the ICD a
This spending item is part of a $793,292 allocation. See details
National Institutes of Health 7/16/2009
DUKE UNIVERSITY $780,000 Trans-NIH Recovery Act Research Support 'The overall goal of the proposed research is to further elucidate mechanisms of allogeneic stem cell education in patients with severe combined immunodeficiency (SCID) given transplants of rigorously T cell- depleted HLA-identical or haploidentical relat National Institutes of Health 7/22/2009
DUKE UNIVERSITY $780,000 Trans-NIH Recovery Act Research Support This project concerns the role of ectopic dentate granule cells in temporal lobe epilepsy. The dentate gyrus is believed to act as a gatekeeper or filter to inhibit the propagation of synchronized discharge through the limbic circuit. In both temporal lob National Institutes of Health 7/17/2009
DUKE UNIVERSITY $780,000 Trans-NIH Recovery Act Research Support Development and function of the ocular lens depends on controlled proliferation of epithelial cells, and on migration, elongation, adhesion, and cytoarchitecture of the resulting fiber cells. Neither the identity of the molecular mechanisms that regulate National Institutes of Health 6/03/2009
DUKE UNIVERSITY $780,000 Trans-NIH Recovery Act Research Support Understanding the mechanisms of limbic epileptogenesis may lead to novel disease modifying therapies. We have discovered that epileptogenesis is associated with enhanced activation of TrkB in the mossy fiber pathway of hippocampus. We have also discovered National Institutes of Health 9/09/2009
DUKE UNIVERSITY $780,000 Trans-NIH Recovery Act Research Support The emergence of serum antibody responses only after early cellular immune responses have suppressed HIV replication has led to doubts regarding the importance of humoral immunity in controlling HIV infections. Nonetheless, rare, broadly cross-reactive an National Institutes of Health 8/11/2009
DUKE UNIVERSITY $779,806 Trans-NIH Recovery Act Research Support Individuals diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) smoke more than the general population, initiate use at a younger age, and in general report more difficulty trying to quit. Several converging lines of work suggest that the high National Institutes of Health 7/16/2009
DUKE UNIVERSITY $779,601 Trans-NIH Recovery Act Research Support Contraction of cardiac and skeletal muscle depends in large part on the amount of calcium released from the intracellular calcium store called the sarcoplasmic reticulum (SR).The regulation of this SR calcium is therefore fundamental to heart and muscle p National Institutes of Health 6/01/2009
DUKE UNIVERSITY $779,421 Trans-NIH Recovery Act Research Support The broad, long-term objective of the proposed research is to elaborate an approach for a comprehensive analysis of data on health-related changes in aging individuals by developing tools for integrative analyses of distinct types of longitudinal data and National Institutes of Health 8/14/2009
DUKE UNIVERSITY $767,680 Trans-NIH Recovery Act Research Support The actions of the renin-angiotensin system (RAS) to control blood pressure are primarily mediated by type I (AT1) angiotensin receptors. In work done during the previous funding period using a kidney cross- transplantation model, we demonstrated distinct National Institutes of Health 9/10/2009
DUKE UNIVERSITY $761,727 Trans-NIH Recovery Act Research Support This application addresses Challenge Area (04) Clinical Research and specific Challenge Topic 04-HL-114: Using existing datasets to plan effectiveness trials in pediatric cardiology. Most of the treatments used in children undergoing congenital heart surg
This spending item is part of a $847,352 allocation. See details
National Institutes of Health 9/21/2009
DUKE UNIVERSITY $753,280 Trans-NIH Recovery Act Research Support The purpose of this proposal is to understand how ectopic signaling through the acetylcholine pathway results in changes that eventually influence adult learning and behavior. This will involve looking at the influences of exciting acetylcholine activate National Institutes of Health 9/20/2009
DUKE UNIVERSITY $750,486 Trans-NIH Recovery Act Research Support The long-term goal of this project is to understand the fundamental aspects of outer membrane vesicles produced by Gram-negative bacteria: How and why are they made? Outer membrane vesicles represent 0.1 to 1% of total outer membrane protein in a growing National Institutes of Health 7/17/2009
XINRAY SYSTEMS INC $734,814 Trans-NIH Recovery Act Research Support ARRA - Nanotechnology enabled desktop image-guided microbeam radiation therapy system Today, state-of-the-art radiotherapy provides excellent benefits for patients with early stage and radiosensitive cancers. However, these benefits diminish for patients
This spending item is part of a $1,657,876 allocation. See details
National Institutes of Health 9/29/2009
DUKE UNIVERSITY $732,237 Trans-NIH Recovery Act Research Support Explore and establish a web service or platform that serves as a common user interface. Current software was developed indepently by various labs using different third party libraries and coding languages ( C++, Java, Matlab and R) and using a variety of National Institutes of Health 4/23/2010
DUKE UNIVERSITY $724,692 Trans-NIH Recovery Act Research Support Although there is mounting evidence that strategically designed and targeted public service announcement (PSA) campaigns can reduce drug abuse by adolescents, a recent report by the Government Accountability Office concluded that the $1.4 billion National National Institutes of Health 5/14/2009
DUKE UNIVERSITY $704,541 Trans-NIH Recovery Act Research Support This application, to be supported for 1 year with bridge funds from ARRA, explores the long term outcomes of thymus transplantation. Over the last 15 years, our laboratory has established that thymus transplantation is a successful therapeutic strategy f National Institutes of Health 9/11/2009
DUKE UNIVERSITY $702,000 Trans-NIH Recovery Act Research Support Note: This project is being supported with funds from the American Recovery and Reinvestment Act, which resulted in a reduction in the research aims and scope. A revised abstract has been provided. Age-related macular degeneration (AMD) is a late-onset, National Institutes of Health 7/20/2009
LINCOLN COMMUNITY HEALTH CENTER, INCORPORATED $698,961 ARRA Health Center Integrated Services Development Initiative[g1] The ARRA Increased Demand for Services (IDS) grant has enabled Lincoln Community Health Center (LCHC) to achieve its goal to hire additional provider and patient support staff to expand existing health center services by extending dail... Show more Health Resources and Services Administration 3/27/2009
DUKE UNIVERSITY $695,811 ARRA - Health Information Technology Professionals in Health Care The need for trained health IT workers has never been greater. Without the efforts proposed by the Office of the National Coordinator, the shortage of Health IT workers in the United States will worsen and inhibit much needed improveme... Show more
This spending item is part of a $1,820,000 allocation. See details
Health and Human Services, Department of 4/02/2010
DUKE UNIVERSITY $682,887 Trans-NIH Recovery Act Research Support The CALGB will implement an initiative from the Clinical Trials Evaluation Program (CTEP) to incorporate new tools/technologies into the NCI/CTEP-sponsored Cooperative Group and Consortia infrastructure supporting multi-institutional clinical trials. Thi National Institutes of Health 9/18/2009
DUKE UNIVERSITY $681,214 Trans-NIH Recovery Act Research Support Prostate cancer (PCa) is the most common cancer among men in the U.S. One important strategy to address this public health concern is to prevent the disease. Two large randomized clinical trials, The Prostate Cancer Prevention Trial (PCPT) and The Reducti
This spending item is part of a $3,978,770 allocation. See details
National Institutes of Health 9/29/2009
DUKE UNIVERSITY $650,467 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area #8, Genomics, and specific Challenge Topic 08-HL-101, which seeks to identify causal genetic variants associated with heart, lung, and blood diseases by application of targeted DNA capture and massively para
This spending item is part of a $999,815 allocation. See details
National Institutes of Health 9/21/2009
DUKE UNIVERSITY $647,400 Trans-NIH Recovery Act Research Support HDAC inhibitors (HDACI) are promising anti-tumor agents that have just entered the clinics. Despite their potent activity, the fundamental question of how HDAC inhibitors achieve their anti-tumor effects remains poorly understood. It is not known which of National Institutes of Health 7/16/2009
DUKE UNIVERSITY $647,400 Trans-NIH Recovery Act Research Support Lung cancer is the leading cause of cancer related death in the United States. Gene expression profiles in non- small cell lung cancer (NSCLC) reflect unique aspects of individual tumors and provide precise prognostic information. In previously published National Institutes of Health 8/14/2009
DUKE UNIVERSITY $647,400 Trans-NIH Recovery Act Research Support DNA mismatch repair (MMR) is a major contributor to genome stability. MMR corrects DNA biosynthetic errors, ensures the fidelity of genetic recombination and is required for the cellular response to certain classes of DNA damage, including lesions induced National Institutes of Health 9/30/2009
RESEARCH TRIANGLE INSTITUTE $643,805 Under the direction of the U.S. Centers for Disease Control and Prevention's Office on Smoking and Health, RTI International will provide expertise and technical assistance to support CDC-OSH and states in the production and maximum utilization of high-qu
This spending item is part of a $1,075,625 allocation. See details
Centers for Disease Control and Prevention 8/30/2010
DUKE UNIVERSITY $643,208 Trans-NIH Recovery Act Research Support The regulatory nature and physical structure of chromatin are dynamically regulated by post- translational modifications of core histone proteins. The recent discovery of histone demethylases has initiated a rapid increase in our knowledge about the regul National Institutes of Health 6/05/2009
DUKE UNIVERSITY $641,358 Trans-NIH Recovery Act Research Support The overall goal of this proposal is to develop a novel local drug delivery system for cancer radiotherapy by direct intratumoral administration of a thermally sensitive macromolecule conjugated to a therapeutic radionuclide of interest. Thermally sensiti National Institutes of Health 5/14/2009
DUKE UNIVERSITY $638,919 Trans-NIH Recovery Act Research Support We propose to study US trends in the prevalence of cognitive impairment and dementia by performing a new Aging, Demographics, and Memory Study (ADAMS 2010) that uses a similar methodology to that employed for the original NIA-funded study performed in 200
This spending item is part of a $1,100,000 allocation. See details
National Institutes of Health 9/29/2009
DUKE UNIVERSITY $637,594 Trans-NIH Recovery Act Research Support The purpose of this predoctoral and postdoctoral research training program is to provide rigorous training in the general fields of social, medical, and economic demography of aging. A major focus is placed on five substantive areas: a) biodemography, inc National Institutes of Health 5/21/2009
DUKE UNIVERSITY $629,385 Trans-NIH Recovery Act Research Support The risk for developing end-stage renal disease (ESRD) in African Americans is more than 3-fold higher than European Americans. This disproportionate risk is apparent for virtually all forms of kidney disease, but only a minor portion can be explained by
This spending item is part of a $999,385 allocation. See details
National Institutes of Health 9/22/2009
DUKE UNIVERSITY $621,343 Trans-NIH Recovery Act Research Support Chronic diseases of the brain such as Alzheimer's disease (AD) impact an estimated 5 million individuals in the US. While progress has been made in identifying specific mutated genes that initiate a neurodegenerative disease process, we have limited infor
This spending item is part of a $953,758 allocation. See details
National Institutes of Health 9/24/2009
DUKE UNIVERSITY $614,162 Trans-NIH Recovery Act Research Support The murine antibody repertoire experiences a series of expansions and contractions that coincide with specific stages of B-cell development and differentiation. The initial repertoire of antibody specificities generated by V(D)J recombination is reduced d National Institutes of Health 7/22/2009
DUKE UNIVERSITY $614,162 Trans-NIH Recovery Act Research Support Interleukin 7 (IL-7) has been demonstrated to provide signals via the IL-7 receptor which are required at many stages of lymphocyte development. IL-7 receptor is composed of two different cytokine receptor subunits; the IL-7 receptor alpha chain and the c National Institutes of Health 7/17/2009
ENDACEA, INC $609,126 Trans-NIH Recovery Act Research Support Despite the availability of newer antimicrobial agents, improved supportive care, and the introduction of an FDA approved adjunctive therapy for sepsis, (Xigris(r), drotrecogin alfa), the mortality rate for severe sepsis and septic shock of 30-60% remains
This spending item is part of a $1,069,972 allocation. See details
National Institutes of Health 9/01/2009
DUKE UNIVERSITY $608,023 Trans-NIH Recovery Act Research Support Cdk/Cyclin complexes drive progression through the eukaryotic cell cycle. Entry into mitosis is triggered by Cdk1 (Cdc2)/Cyclin B complexes, while M phase exit requires Cyclin B degradation and dephosphorylation of mitotic phosphoproteins. The destruction National Institutes of Health 9/17/2009
DUKE UNIVERSITY $608,021 Trans-NIH Recovery Act Research Support To survive within the hostile environment of the infected host, pathogenic microorganisms must be able to sense and adapt to changing environmental conditions. This adaptation requires a coordinated regulation of multiple factors for growth and survival. National Institutes of Health 5/14/2009
RESEARCH TRIANGLE INSTITUTE $605,065 The purpose of this contract is to designate a national public relations firm to create a Publicity Center to enhance the ongoing AHRQ efforts to publicize and market comparative effectiveness research reports and associated materials to specific audience
This spending item is part of a $17,999,988 allocation. See details
Agency for Healthcare Research and Quality 9/30/2010
RESEARCH TRIANGLE INSTITUTE $603,558 Trans-NIH Recovery Act Research Support The goal of this program is to develop safe neurotransmitter releasers as potential treatments for drug abuse and addiction without the undesirable side effects seen with releaser medications such as Fen-Phen. It is believed that such side effects are in National Institutes of Health 9/28/2009
DUKE UNIVERSITY $601,040 Trans-NIH Recovery Act Research Support 1. Instrument development: We will design and implement new coherence imaging instrumentation to enable examination of colorectal tissues for ex vivo studies. For the a/LCI surveillance studies, we will develop new fiber optic probe designs suitable for
This spending item is part of a $633,697 allocation. See details
National Institutes of Health 5/21/2009
DUKE UNIVERSITY $599,581 Trans-NIH Recovery Act Research Support This application is in response to the NCRR Administrative Supplements for Research Workforce Development and Dissemination. Training in Health Informatics for practitioners, clinical and translational scientists, and healthcare leaders is critical to two National Institutes of Health 8/17/2009
DUKE UNIVERSITY $585,000 Trans-NIH Recovery Act Research Support Millions of Americans develop chest pain suggestive of coronary heart disease each year and often require non-invasive diagnostic testing. However, currently available tests are imprecise, robust evidence regarding optimal test choice is limited, and test National Institutes of Health 9/29/2009
DUKE UNIVERSITY $584,753 Trans-NIH Recovery Act Research Support The goal of this project is to establish an effective, practical, and widely available medical countermeasure to mitigate radiation-induced lung injury by utilizing metalloporphyrin antioxidant mimetic based strategies. This project is strongly focused on
This spending item is part of a $1,000,000 allocation. See details
National Institutes of Health 8/09/2010
DUKE UNIVERSITY $576,978 Trans-NIH Recovery Act Research Support The primary objective of the activities proposed in this application is to provide optical coherence tomography (OCT) Reading Center support to the Comparison of Age Related Macular Degeneration Treatment trials (CATT). The long term goals of this project National Institutes of Health 9/14/2009
RESEARCH TRIANGLE INSTITUTE $568,481 Trans-NIH Recovery Act Research Support This project will develop the chemical tools that will enable researchers to study certain proteins in the body to better understand their reactions to various chemicals and interactions with each other. By understanding these protein interactions, improv National Institutes of Health 5/14/2009
HAMNER INSTITUTES, THE $567,456 Trans-NIH Recovery Act Research Support Drug-induced liver injury (DILI) is the major adverse drug event that leads to regulatory actions on drugs, including failure to approve, restricted indications, and withdrawal from the marketplace. The most problematic form of DILI is ?idiosyncratic?, m
This spending item is part of a $992,501 allocation. See details
National Institutes of Health 9/28/2009
DUKE UNIVERSITY $561,435 Trans-NIH Recovery Act Research Support The proposed project will promote expanded and improved community engagement (CE) by academic medical centers (AMCs) through two related activities: 1) collaboratively rewriting the CDC's seminal 'Principles of Community Engagement' (PCE), and 2) implemen
This spending item is part of a $598,935 allocation. See details
National Institutes of Health 8/13/2009
DUKE UNIVERSITY $558,593 Trans-NIH Recovery Act Research Support Our long-term goal is to understand the organization of the brainstem auditory pathways in terms of connections among the multiple neuronal types that form them. The objective of the proposed studies is an analysis of the origins and terminations of speci
This spending item is part of a $612,800 allocation. See details
National Institutes of Health 8/14/2009
RESEARCH TRIANGLE INSTITUTE $550,000 Trans-NIH Recovery Act Research Support A consortium of obstetric researchers recently has been brought together, with NICHD support, to investigate the genomic and proteomic basis for adverse pregnancy outcomes in nulliparous women (Preterm Birth in Nulliparous Women: An Understudied Populatio National Institutes of Health 7/13/2010
TECAN US INC. $550,000 DNA Sample processing work cell. National Institutes of Health 10/08/2009
SYSTEMS RESEARCH AND APPLICATIONS CORPORATION $544,995 The purpose of this award is to support required IT System Enhancements for the NIEHS Division of Extramural Research and Training (DERT) Granting activities following an analysis of expansion requirements New systems are to be configured and deployed wi National Institutes of Health 2/19/2010
DUKE UNIVERSITY $544,505 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (04): Clinical Research and specific Challenge Topic 04-AG-107: Mechanisms of specific benefits of different types of physical activity. MECHANISMS AND FUNCTIONAL OUTCOMES OF EXERCISE PROGRESSION MODELS IN T
This spending item is part of a $997,347 allocation. See details
National Institutes of Health 9/24/2009
DUKE UNIVERSITY $534,001 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (15) Translational Science, and the specific Challenge Topic, 15-NS-106: Identifying mechanisms that underlie nervous system development and function. This Challenge solicits mechanistic studies that elucida National Institutes of Health 9/25/2009
GLOBAL VACCINES INC $518,489 Trans-NIH Recovery Act Research Support A Novel Sysstemic and Mucosal Adjuvant for Biodefense. National Institutes of Health 6/28/2010
DUKE UNIVERSITY $517,920 Trans-NIH Recovery Act Research Support RNA aptamers have been generated against a variety of proteins including a few cell surface receptors. In general such aptamer act as potent inhibitors of their target proteins both in vitro and in vivo. Moreover, a few of these antagonistic aptamers have National Institutes of Health 5/21/2009
DUKE UNIVERSITY $515,629 The present application addresses a major area of concern in the substance use field G?? the association between attention-deficit/hyperactivity disorder (ADHD) in childhood and patterns of substance use, abuse, and dependence (as well as desistance) in l
This spending item is part of a $756,423 allocation. See details
National Institutes of Health 4/22/2010
DUKE UNIVERSITY $512,261 Trans-NIH Recovery Act Research Support This application addresses the broad Challenge Area (08), Genomics, and the specific Challenge Topic (08-ES-106), The role of environmental exposure in copy number variation (CNV). CNV events are deletions or duplications that are too small to be recogniz
This spending item is part of a $993,020 allocation. See details
National Institutes of Health 9/26/2009
DUKE UNIVERSITY $504,500 Trans-NIH Recovery Act Research Support Administrative Supplement-2/2 A genome-wide association study to detect genetic variation for schizophrenia Clozapine (CLO) is one of the most effective antipsychotics but its use is limited by the risk of agranulocytosis, an uncommon but serious advers
This spending item is part of a $2,000,000 allocation. See details
National Institutes of Health 5/31/2010
DUKE UNIVERSITY $500,000 Trans-NIH Recovery Act Research Support The objectives of this animal facilities improvement grant application are to upfit the Bryan animal facility as follows: 1) Replace the antiquated cage washer and add an autoclave to support a wider variety of rodent housing; 2) add a biological safety c National Institutes of Health 7/16/2009
DUKE UNIVERSITY $499,980 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic, 06-MH-102: Technologies to study neuronal signaling, plasticity, and neurodevelopment. The complex and diverse functions of the brain depend on the un National Institutes of Health 9/25/2009
DUKE UNIVERSITY $499,775 Trans-NIH Recovery Act Research Support This is a request for a 2-photon intravital laser scanning confocal fluorescence microscopy system -intravital confocal microscope- for a variety of projects involving confocal imaging of living mice. The system will be installed in the Light Microscopy C National Institutes of Health 5/06/2010
DUKE UNIVERSITY $485,096 Trans-NIH Recovery Act Research Support Identifying potential regulatory mechanisms controlling aqueous humor outflow resistance has important implications for understanding glaucoma and developing effective therapies. We hypothesize that Rho/Rho kinase signaling pathway regulated cytoskeletal National Institutes of Health 8/04/2009
DUKE UNIVERSITY $481,308 Trans-NIH Recovery Act Research Support The title of this award is Primary Immune Deficiency Treatment Consortium (PIDTC). Primary immune deficiencies (PIDs) are rare, life-threatening inherited defects in the immune system. Specific goals are to characterize the long term outcomes and late ef
This spending item is part of a $2,483,108 allocation. See details
National Institutes of Health 9/11/2009
DUKE UNIVERSITY $468,000 Trans-NIH Recovery Act Research Support This application is in response to RFA DA-09-016, 'Behavioral Pharmacology and Genetics, Translating and Targeting Individual Differences.' The proposed project will examine the genetic basis of individual differences in inhibitory control (IC) and how th National Institutes of Health 8/31/2009
DUKE UNIVERSITY $464,942 Trans-NIH Recovery Act Research Support This application, to be supported for 1 year with bridge funds from ARRA, explores the long term outcomes of thymus transplantation. Over the last 15 years, our laboratory has established that thymus transplantation is a successful therapeutic strategy f National Institutes of Health 9/23/2009
DUKE UNIVERSITY $461,402 Trans-NIH Recovery Act Research Support The explosive growth of computational biology has made it difficult for research organizations to keep pace with users' demands for ever-increasing computational power. The complications that biologists face come from two developments. First, new technolo National Institutes of Health 6/01/2009
DUKE UNIVERSITY $456,500 Trans-NIH Recovery Act Research Support Duke University Medical Center currently has 21 investigators in need of state-of-the-art technology that combines multispectral (brightfield, darkfield, and fluorescence) imaging with flow cytometry. These investigators come from a wide-range of departme National Institutes of Health 3/04/2010
DUKE UNIVERSITY $446,281 Trans-NIH Recovery Act Research Support Caenorhabditis elegans, a multicellular roundworm of approximately 1000 differentiated cells in adult animals, offers numerous advantages, namely it has an extremely short generation time, and its genome can be readily mutagenized, so that together with r National Institutes of Health 12/09/2009
DURHAM TECHNICAL COMMUNITY COLLEGE $444,038 ARRA - Health Information Technology Professionals in Health Care The need for trained health IT workers has never been greater. Without the efforts proposed by the Office of the National Coordinator, the shortage of Health IT workers in the United States will worsen and inhibit much needed improveme... Show more
This spending item is part of a $1,820,000 allocation. See details
Health and Human Services, Department of 4/02/2010
DUKE UNIVERSITY $438,566 Trans-NIH Recovery Act Research Support Understanding the relationships between visuospatial and mathematical processing is an important public health challenge. Our research goal is to determine the functional contributions of different parts of the parietal cortex to the extraction of numeric National Institutes of Health 9/30/2009
DUKE UNIVERSITY $434,292 Trans-NIH Recovery Act Research Support Sickle cell anemia is a devastating disease affecting primarily African Americans. Our goals are to capture the genetic diversity that is likely to underlie the notoriously heterogeneous clinical course of this disease, and with this information, develop
This spending item is part of a $2,981,256 allocation. See details
National Institutes of Health 9/28/2009
DUKE UNIVERSITY $429,423 Trans-NIH Recovery Act Research Support The Broad Challenge Area addressed in this proposal is (03) Biomarker Discovery and Validation, and the Specific Challenge Topic is 03-HL-101. The purpose of this proposal is to improve the accurate and early diagnosis of idiopathic interstitial lung pneu
This spending item is part of a $916,670 allocation. See details
National Institutes of Health 9/18/2009
DUKE UNIVERSITY $429,000 Trans-NIH Recovery Act Research Support Chronic pathological pain and certain epileptic syndromes are neuropsychiatric disorders that share an increased female prevalence and refractoriness to treatment. The latter feature is considered to be linked to pathologically increased neuronal excitabi National Institutes of Health 5/15/2009
DUKE UNIVERSITY $429,000 Trans-NIH Recovery Act Research Support This project will develop and apply methods to analyze functioning of a microbicide product vaginal epithelial coating layer - to inhibit transport of HIV virions from semen to tissue and enable microbicide molecules to disable virus. We will contribute t National Institutes of Health 5/29/2009
DUKE UNIVERSITY $429,000 Trans-NIH Recovery Act Research Support Malignant glioma is characterized by early local invasion, microsatellite infiltration of healthy CNS tissue and dispersion of tumor cells in distant parenchyma. These characteristics significantly hamper the success of surgical or radiation treatment, si National Institutes of Health 9/15/2009
DUKE UNIVERSITY $429,000 Trans-NIH Recovery Act Research Support A large body of evidence suggests that ion channels act as force sensors in mechanotransduction systems. In flies, the No mechanoreceptor potential-C (Nomp-C) channel has been suggested to be a force transduction channel in neurons that detect bristle def National Institutes of Health 7/17/2009
DUKE UNIVERSITY $429,000 Trans-NIH Recovery Act Research Support Ischemic stroke is caused by cerebral blood flow (CBF) inadequate to allow brain tissue survival. It is known from humans treated with tissue plasminogen activator that ischemic tissue can be salvaged from infarction by thrombolytic CBF restoration. This National Institutes of Health 5/15/2009
DUKE UNIVERSITY $429,000 Trans-NIH Recovery Act Research Support Cytokines produced by CD4+ T lymphocytes play essential roles in host adaptive immune responses and are involved in the development of allergic diseases including asthma. Our understanding of the pathways regulating cytokine production in CD4+ T lymphocyt National Institutes of Health 5/14/2009
DUKE UNIVERSITY $428,508 Trans-NIH Recovery Act Research Support Primary malignant brain tumors, like glioblastoma (GBM), remain universally fatal. Like most neoplasms, they develop through the acquisition of multiple genetic alterations that lead to a heterogeneous deregulation of cell signaling pathways. Despite this National Institutes of Health 9/24/2009
DUKE UNIVERSITY $423,066 Trans-NIH Recovery Act Research Support We are requesting a versatile system to improve our ability and capacity for a variety of live cell imaging projects. The instrument would be located in the Light Microscopy Core Facility (LMCF), a large established core that serves over 550 users across National Institutes of Health 4/22/2010
DUKE UNIVERSITY $422,608 Trans-NIH Recovery Act Research Support This study will examine maturation of vasomotor tone by measuring central and peripheral body temperature of 30 extremely low birth weight (ELBW) infants in relationship to peripheral perfusion during the first 5 days of life. We will examine the ability
This spending item is part of a $478,576 allocation. See details
National Institutes of Health 3/15/2010
DUKE UNIVERSITY $421,645 Trans-NIH Recovery Act Research Support This project will examine how genetic differences relate to a diagnosis of MRI-defined vascular depression and in turn, severity of cerebral ischemic lesions. This study is relevant to older populations where approximately half of older depressed individ National Institutes of Health 5/19/2010
DUKE UNIVERSITY $420,600 Trans-NIH Recovery Act Research Support The goal of this research is to elucidate the physiological and molecular responses that occur in response to persistent mitochondrial DNA (mtDNA) damage. Mitochondrial DNA integrity is critical for human health, and mtDNA is more sensitive than nuclear D National Institutes of Health 5/15/2009
DUKE UNIVERSITY $413,230 ARRA - Nurse Faculty Loan Program In the 16 states in the Southern Regional Education Board (SREB) Council on Collegiate Education, there is a severe nursing faculty shortage. According to the North Carolina Board of Nursing report on educational trends for 2009, there are 127 full-time n Health Resources and Services Administration 6/14/2010
DUKE UNIVERSITY $412,001 Trans-NIH Recovery Act Research Support The central question of the parent award is to understand the relationship between cortico-striatal synaptic function and pathological behaviors. The initial step toward this was to understand the striatal synaptic defects created by deletion of the SAPAP National Institutes of Health 9/15/2009
RESEARCH TRIANGLE INSTITUTE $411,222 Trans-NIH Recovery Act Research Support This project will refine an intervention to reduce sexual and injection risk behaviors that lead to infection with HIV and other sexually transmitted infections (STIs) and the hepatitis C virus (HCV) for use in rural areas. The intervention features a sy National Institutes of Health 7/16/2009
DUKE UNIVERSITY $407,160 Trans-NIH Recovery Act Research Support NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Administrative Supplements This Administrative Supplement proposes feasible aims that will enhance all of our funded NIH grants but especially the highly significant parent grant wher National Institutes of Health 9/29/2009
DUKE UNIVERSITY $405,437 Trans-NIH Recovery Act Research Support This competitive revision is submitted in response to Notice Number NOT-OD-09-058, 'Enabling RPGs to Leverage NCRR Center and Center-like Programs' and 'NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications.' Infants b
This spending item is part of a $850,201 allocation. See details
National Institutes of Health 9/30/2009
RESEARCH TRIANGLE INSTITUTE $404,548 Trans-NIH Recovery Act Research Support The goal of this project is to develop a new method for studying how dietary supplements affect the epigenome, biochemical reactions at the level of the DNA that turn genes on and off. This research will develop a method for uncovering genes that are most National Institutes of Health 5/07/2009
DUKE UNIVERSITY $400,000 Trans-NIH Recovery Act Research Support The broad and long term objectives of this research application focuses on rapid biodosimetry and mitigation of radiation injury as well as advancing education in this area. Many individuals believe that the single greatest threat to America is nuclear pr National Institutes of Health 9/21/2009
DUKE UNIVERSITY $400,000 Trans-NIH Recovery Act Research Support DTRI uses an innovative, focused, and proactive approach with its pilot projects that has increased our success in translation. The supplemental funding will be used to fund two projects (1) 'PTEN Gene Therapy for the Prevention of Vein Graft Disease' and National Institutes of Health 8/13/2009
METABOLON, INC. $400,000 Trans-NIH Recovery Act Research Support This is an administrative supplement, to a parent award which investigates the interaction between genetic variation and modifiable environments in the determination of incident coronary heart disease (CHD). The investigator's percent effort and salary s
This spending item is part of a $533,968 allocation. See details
National Institutes of Health 9/29/2009
RESEARCH TRIANGLE INSTITUTE $396,313 RTI International?s project supports ARRA by strengthening the evidence base of the 317 Immunization Grant Program and the reporting methods used by its 64 grantees. RTI?s project will strengthen the evidence base by using ARRA funds to identify, evaluate Centers for Disease Control and Prevention 2/01/2010
DUKE UNIVERSITY $392,500 Trans-NIH Recovery Act Research Support Herpes Simplex Virus 1 (HSV-1) and HSV-2 are related human ?-herpesviruses that share the ability to establish long-term latent infections in neurons of primary sensory ganglia. Like other herpesviruses, HSV-1 and HSV-2 express virally encoded microRNAs ( National Institutes of Health 7/26/2010
DUKE UNIVERSITY $392,500 Trans-NIH Recovery Act Research Support Human autoinflammatory syndromes represent a diverse set of diseases, including hereditary periodic fevers (HPF), Type 2 diabetes and gout, which are characterized by overexpression of IL-1b in the absence of recognized inflammatory stimuli. IL-1b is mad National Institutes of Health 6/14/2010
DUKE UNIVERSITY $391,250 Trans-NIH Recovery Act Research Support Methamphetamine (METH) addiction is a global problem, and has now reached epidemic proportions in certain Western, Midwestern, and Southern states including North Carolina. Total abstinence from METH is very difficult to achieve in the clinic, mainly beca National Institutes of Health 5/04/2009
DUKE UNIVERSITY $377,520 Trans-NIH Recovery Act Research Support Pancreatic cancer is a devastating disease, causing an estimated 33,370 deaths per year in the USA with a five-year survival rate of only 5%. The molecular hallmark of this cancer is an activating mutation in the small GTPase KRas, which is well known to National Institutes of Health 5/17/2009
DUKE UNIVERSITY $369,999 Trans-NIH Recovery Act Research Support Liver injury caused by prescription drugs is the single most important reason for regulatory actions by the Food & Drug Administration, including failure to gain approval and removal from the market. These drug-induced liver injuries (DILIs) are usually i National Institutes of Health 9/29/2009
RESEARCH TRIANGLE INSTITUTE $367,320 Trans-NIH Recovery Act Research Support The supplemental funding will be used to accelerate development of a dedicated dissemination Web site to provide the health research community with easy access to a variety of geospatial databases being developed under the parent NIH-funded research progr National Institutes of Health 9/28/2009
DUKE UNIVERSITY $356,070 Trans-NIH Recovery Act Research Support Natural products show outstanding potential as starting point in drug discovery, especially in the quest for anticancer drugs. The research proposed here will explore structure-activity relationships of largazole, a marine natural product that shows nano
This spending item is part of a $641,285 allocation. See details
National Institutes of Health 5/15/2009
DUKE UNIVERSITY $353,375 Trans-NIH Recovery Act Research Support The goal of these investigations is to elucidate the role of microparticles (MPs) as a key source of nuclear antigens in systemic lupus erythematosus (SLE) and characterize these structures as components of pathogenic immune complexes (ICs). MPs are small National Institutes of Health 5/21/2009
DUKE UNIVERSITY $353,375 Trans-NIH Recovery Act Research Support Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that primarily affects young women and powerfully exemplifies the importance of sex as a determinant of immune-mediated disease. Indeed, among autoimmune and inflammatory diseases, SLE National Institutes of Health 7/17/2009
DUKE UNIVERSITY $345,735 Trans-NIH Recovery Act Research Support Whereas dementia and stroke affect only fraction of the population, there is a type of brain dysfunction that will affect all of us G??if we live long enough: normal aging. As we age, the anatomical and functional integrity of our brain declines, and so National Institutes of Health 9/21/2010
DUKE UNIVERSITY $343,204 Trans-NIH Recovery Act Research Support Clinical data support the concept that both normal stem cells and leukemia stem cells exhibit multiple drug resistance. However, it is unclear how mechanisms for drug resistance might interrelate with stem cell physiology. Our preliminary studies have exp National Institutes of Health 4/30/2009
DUKE UNIVERSITY $343,199 Trans-NIH Recovery Act Research Support We study the mechanisms that govern the partitioning of mRNAs between the cytosol and endoplasmic reticulum (ER) of eukaryotic cells. This transcriptome sorting process is arguably the most universal of the mRNA localization events and is responsible for National Institutes of Health 9/30/2009
DUKE UNIVERSITY $340,416 Trans-NIH Recovery Act Research Support Important concerns have been raised about the ethics of phase 1 clinical trials in oncology. In previous research, many patients have reported high expectations of personal clinical benefit from phase 1 trials. In the project leading to this application (
This spending item is part of a $674,806 allocation. See details
National Institutes of Health 6/04/2009
RESEARCH TRIANGLE INSTITUTE $329,475 The purpose of this contract is to develop a database of State-level (and selected sub-State-level) environmental factors and program characteristics for the Medicaid and ChildrenG??s Health Insurance Program (CHIP) that can be linked to the Medicaid Anal
This spending item is part of a $858,436 allocation. See details
Health Care Financing Admin. (was Medicare and Medicaid Serv.) 3/31/2010
DUKE UNIVERSITY $329,000 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): The survival of every species depends on the faithful inheritance of genetic information. Essential to this process are the accurate movement and positioning of chromosomes and plasmids to daughter cells at cell divis National Institutes of Health 3/17/2011
DUKE UNIVERSITY $322,191 Trans-NIH Recovery Act Research Support This topic specifically targets developing a deep and diverse understanding of genetic maps and recombination within and between species, which is what our proposal intends to study. Project Title: Fine-scale recombination rate variation within and betwee
This spending item is part of a $1,834,345 allocation. See details
National Institutes of Health 9/28/2009
DUKE UNIVERSITY $310,969 Trans-NIH Recovery Act Research Support Cigarette smoking is highly prevalent among persons with posttraumatic stress disorder (PTSD) and individuals with PTSD have decreased odds of successfully quitting smoking. There is a need to develop more effective interventions and to evaluate factors a National Institutes of Health 5/07/2009
DUKE UNIVERSITY $309,808 Trans-NIH Recovery Act Research Support Overview and Specific Aims In April, 2004, the Center for Comparative Biology of Vulnerable Populations (CCBVP) was established at Duke University as part of NIEHS?s portfolio of Environmental Health Sciences Research Centers. The CCBVP has achieved dist National Institutes of Health 9/02/2009
DUKE UNIVERSITY $306,055 Trans-NIH Recovery Act Research Support Anorexia Nervosa (AN) has the highest mortality rate of all psychiatric illnesses. It is a debilitating condition characterized by extreme malnourishment and the potential for significant physical and psychological sequelae. AN often emerges in adolescenc
This spending item is part of a $405,693 allocation. See details
National Institutes of Health 5/05/2009
DUKE UNIVERSITY $301,712 Trans-NIH Recovery Act Research Support AN OPEN SOURCE RESEARCH PERMISSIONS FRAMEWORK FOR SOUTH CAROLINA PROJECT NARRATIVE The current Grand Opportunity grant will allow the SC Center of Economic Excellence in Healthcare Quality (CHQ) to accelerate its planned clinical and translational researc
This spending item is part of a $4,828,009 allocation. See details
National Institutes of Health 9/30/2009
DUKE UNIVERSITY $301,553 Trans-NIH Recovery Act Research Support Specific Aim 2 of the parent project involves mechanistic studies of the N-terminal antibody binding domain of Staphylococcal protein A (SpA-N). This 291 residue protein is composed of five nearly identical 56 +? 61 residue domains. The proposed sub-proj National Institutes of Health 8/10/2009
RESEARCH TRIANGLE INSTITUTE $299,373 This study is designed to develop a methodology to generate a national annual estimate of childhood serious emotional disturbance (SED) within the National Health Interview Survey (NHIS). This childrenG??s mental health surveillance study will include di Centers for Disease Control and Prevention 9/24/2010
RESEARCH TRIANGLE INSTITUTE $295,492 Trans-NIH Recovery Act Research Support The National Institute on Drug Abuse has funded the Promise Neighborhood Research Consortium (PNRC) to assist the people from high-poverty neighborhoods in America to learn about and understand existing knowledge about prevention and to work together
This spending item is part of a $3,402,213 allocation. See details
National Institutes of Health 9/30/2009
DUKE UNIVERSITY $294,155 ARRA ? Equipment to Enhance Training for Health Professionals The purpose of this project as authorized in Public Health Service Act, Title VIII, Section 831, and The American Recovery and Reinvestment Act of 2009, is to strengthen capacity for basic nurse education, practice and retention; and speci... Show more Health Resources and Services Administration 9/04/2010
DUKE UNIVERSITY $294,009 Trans-NIH Recovery Act Research Support I am requesting an administrative supplement for an NIH-funded application (HL081395) under the auspices of the American Recovery and Reinvestment Act of 2009 (NOT-OD-056). The goals of this administrative supplement are to accelerate the pace of proposed National Institutes of Health 8/01/2009
DUKE UNIVERSITY $292,500 Duke University has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of breast cancer specimens (100 cases). These cases are all primary and untreated. National Institutes of Health 4/30/2010
DUKE UNIVERSITY $292,500 Aim 1 - To continue the activities of the ovarian cancer association consortium (OCAC), a group that is dedicated to working together to identify and validate common low penetrance ovarian cancer susceptibility polymorphisms. OCAC will continue to meet ab National Institutes of Health 5/20/2010
DUKE UNIVERSITY $287,694 Trans-NIH Recovery Act Research Support Although recent advances in genomics have revealed a tremendous amount of nucleotide polymorphism, little is known about why genes segregate for variants that influence quantitative traits. This proposed research seeks to determine which evolutionary proc National Institutes of Health 9/09/2009
DUKE UNIVERSITY $287,517 Trans-NIH Recovery Act Research Support Drosophila's Dorsal Closure is a model system for cell sheet morphogenesis during development and wound healing. We plan to investigate the molecular, cellular, and emergent properties that drive morphogenesis during closure using biophysical (laser micro National Institutes of Health 9/25/2009
DUKE UNIVERSITY $286,919 Recovery Act Comparative Effectiveness Research - AHRQ Better continuity of care has been associated with improved quality of care, and reduced emergency room visits and hospitalizations for ambulatory care sensitive conditions. With better continuity, interactions between patients and providers are ... Show more
This spending item is part of a $455,422 allocation. See details
Agency for Healthcare Research and Quality 9/28/2010
NORTH CAROLINA CENTRAL UNIVERSITY $286,032 Trans-NIH Recovery Act Research Support The project is a supplement to the parent grant R01 CA-122704-02. The goals of this Diversity Supplement project are to develop and pilot test cognitive-behavioral coping skills training (CST) protocols tailored for partnered and unpartnered African Ameri
This spending item is part of a $598,592 allocation. See details
National Institutes of Health 9/29/2009
DUKE UNIVERSITY $285,957 Trans-NIH Recovery Act Research Support Innate immune mechanisms are conserved in evolution. The NPR1 protein of Arabidopsis is a master regulator of gene expression in plant defense. Similar to the mammalian immuno- regulator NF-kB, the NPR1 protein is nuclear translocated upon induction. In t National Institutes of Health 9/18/2009
DUKE UNIVERSITY $275,116 Trans-NIH Recovery Act Research Support NOT-OD-09-056 NIH Announces the Availability of Recovery Act Funds for Administrative Supplements: Creating the Encyclopedia of DNA Elements (ENCODE) in the Human Genome U54 The primary focus of our ENCODE group is to generate an open chromatin atlas tha National Institutes of Health 9/30/2009
DUKE UNIVERSITY $272,290 Trans-NIH Recovery Act Research Support Primary open angle glaucoma (POAG) is a leading cause of blindness. This disease disproportionately affects African Americans, who have a four- to five-fold higher risk of disease than age-matched Caucasians. In addition to its high prevalence, the risk o
This spending item is part of a $437,609 allocation. See details
National Institutes of Health 9/01/2009
DUKE UNIVERSITY $267,000 Trans-NIH Recovery Act Research Support Neuroimaging research using parallel acquired functional MRI and high-resolution structural MRI, and dense array electrical recording involves the acquisition of very large data sets that then must be transformed through a series of computation-intensive National Institutes of Health 4/28/2009
DUKE UNIVERSITY $266,476 Trans-NIH Recovery Act Research Support High-resolution and high-speed diffusion-weighted magnetic resonance imaging (MRI) techniques are highly desireable for clinical imaging. The rapidly growing availability of high-field MRI scanners and the increasing number of receiving coils have created National Institutes of Health 8/13/2009
DUKE UNIVERSITY $264,847 Trans-NIH Recovery Act Research Support As part of the modENCODE consortium, we are funded to identify and characterize the functional DNA elements that direct DNA replication throughout the Drosophila genome. The goals of our project, The Systematic Identification and Analysis of Replication O National Institutes of Health 9/30/2009
DUKE UNIVERSITY $262,516 Trans-NIH Recovery Act Research Support This administrative supplement requests additional equipment and personnel. One GRA will work on the structure determination of a large and exciting new protein, whose structure is unknown. This will provide a good test for our algorithms and also an exce National Institutes of Health 9/30/2009
DUKE UNIVERSITY $261,834 Trans-NIH Recovery Act Research Support During metazoan development, large numbers of unwanted cells are eliminated by apoptosis, as are abnormal or dangerous cells in the adult. Correctly regulated apoptosis is essential for normal development and homeostasis of the adult. Our goal is to under National Institutes of Health 9/09/2009
DUKE UNIVERSITY $261,103 Trans-NIH Recovery Act Research Support This Administrative Supplemental Revision is in response to notice number (NOT-OD-09-058). Notice Title: NIH announces the availability of recovery act funds for administrative revision applications. The parent grant, R01DE018549, has the objective of det National Institutes of Health 9/01/2009
DUKE UNIVERSITY $256,930 Trans-NIH Recovery Act Research Support We propose to study US trends in the prevalence of cognitive impairment and dementia by performing a new Aging, Demographics, and Memory Study (ADAMS 2010) that uses a similar methodology to that employed for the original NIA-funded study performed in 200
This spending item is part of a $1,100,000 allocation. See details
National Institutes of Health 9/29/2009
DUKE UNIVERSITY $255,840 Trans-NIH Recovery Act Research Support Our goal is to generate a mouse model that closely resembles Alzheimer's Disease. In our first attempt we have developed two mouse models of AD that progress from A production and amyloid deposition to hyperphosphorylated native mouse tau at AD-associated National Institutes of Health 7/21/2009
DUKE UNIVERSITY $255,221 Trans-NIH Recovery Act Research Support Myopia and glaucoma are highly prevalent ophthalmic disorders worldwide, and contribute significantly to ocular morbidity. There is substantial evidence that genetic factors play a significant role in the development of non-syndromic myopia and glaucoma. National Institutes of Health 9/14/2009
DUKE UNIVERSITY $252,254 Trans-NIH Recovery Act Research Support This proposal is responding to notice NOT-OD-09-056 of the NICHD's FY 2009 program for the American Recovery and Reinvestment Act (ARRA). The parent grant which serves as the umbrella from which this application originates is 5U10-HD041267. The proposed s National Institutes of Health 9/29/2009
DUKE UNIVERSITY $250,000 Trans-NIH Recovery Act Research Support Advanced, metastatic prostate cancer that progresses following hormone (androgen) suppression, has no known cure, and contributes to substantial morbidity and mortality. This proposal aims to categorize advanced castration-resistant prostate cancers into
This spending item is part of a $996,908 allocation. See details
National Institutes of Health 9/29/2009
DUKE UNIVERSITY $246,619 Trans-NIH Recovery Act Research Support The North Carolina Collaborative Pediatric Pharmacology Research Unit (NCC-PPRU) will be composed of personnel from Duke University and the University Of North Carolina (UNC). The NCC-PPRU will help develop new medications with pediatric indications and i National Institutes of Health 7/16/2009
DUKE UNIVERSITY $242,176 Trans-NIH Recovery Act Research Support Our long-term goal is to elucidate the genetic networks that direct cell invasion through basement membranes, the dense, sheet-like extracellular matrix that surrounds most tissues. The mechanisms that cells employ to cross basement membranes in vivo rema National Institutes of Health 9/11/2009
EXECUTIVE OFFICE OF THE STATE OF NORTH CAROLINA $242,110 Aging Congregate Nutrition Services for States ARRA provided funding for Congregate Nutrition Services. Established in 1972 under the Older Americans Act, the program provides meals to older americans in congregate facilities such as senior centers, adult day centers, and faith-based settings.
This spending item is part of a $1,855,370 allocation. See details
Administration on Aging 3/18/2009
PARION SCIENCES, INC $240,000 Trans-NIH Recovery Act Research Support We are developing a therapeutic countermeasure for radiological material inhalation exposure through the product development process. As discussed below, the greatest risk to the lungs following a radiological attack, such as a dirty bomb, results from th
This spending item is part of a $500,000 allocation. See details
National Institutes of Health 9/22/2009
DUKE UNIVERSITY $238,151 Trans-NIH Recovery Act Research Support Ankyrin (ANK) repeats, identified in thousands of proteins, are composed of pairs of antiparallel alpha- helices that stack on top of each other and form super-helical spiral domains with suggestive spring-like properties, whose primary function is to med National Institutes of Health 9/25/2009
DUKE UNIVERSITY $237,616 Trans-NIH Recovery Act Research Support The beta 1 and beta 2 adrenergic receptors are members of the super-family of G protein-coupled receptors (GPCRs). This receptor super-family comprises some of the most important pharmacological targets for the treatment of cardiovascular (e.g. heart fail National Institutes of Health 7/16/2009
DUKE UNIVERSITY $237,273 Trans-NIH Recovery Act Research Support The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has proposed the continuation and expansion of the Drug-Induced Liver Injury Network (DILIN). As described in the RFA, DILIN will evolve into a network of up to 8 Clinical Center National Institutes of Health 3/29/2010
DUKE UNIVERSITY $234,000 Trans-NIH Recovery Act Research Support Cigarette smoking remains the number one preventable cause of premature death in the U.S. In spite of these avoidable consequences, an estimated 60-90% of smokers motivated to attempt to quit relapse within the first year of their attempt. Research sugges National Institutes of Health 7/16/2009
DUKE UNIVERSITY $234,000 Trans-NIH Recovery Act Research Support Smooth muscle (SM) and striated muscle (SKM) are highly plastic, able to adapt their contractile properties in response to a variety of physiological settings such as exercise and pregnancy. Adaptations in these muscles involve coordinated changes in tran National Institutes of Health 5/13/2010
DUKE UNIVERSITY $230,669 Trans-NIH Recovery Act Research Support Application in response to Notice Number: NOT-OD-09-058 Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. Our laboratory has focused on discovering genes that are important for regulating iron homeos National Institutes of Health 11/17/2009
DUKE UNIVERSITY $229,997 Trans-NIH Recovery Act Research Support NOT-OD-09-056 NIH Announces the Availability of Recovery Act Funds for Administrative Supplements: Creating the Encyclopedia of DNA Elements (ENCODE) in the Human Genome U54 The primary focus of our ENCODE group is to generate an open chromatin atlas tha
This spending item is part of a $329,997 allocation. See details
National Institutes of Health 9/30/2009
DUKE UNIVERSITY $228,419 Trans-NIH Recovery Act Research Support Advancing Diffusion Tensor Imaging and Analyses for Basic Alcohol Research - ARR. The purpose of this project is to rapidly advance DTI technology and its application to discovery and documentation of alcohol?s deleterious effects on the pre-and postnatal
This spending item is part of a $903,834 allocation. See details
National Institutes of Health 9/22/2009
OPERATION BREAKTHROUGH, INC. $228,150 ARRA - Head Start Head Start 2009 ARRA COLA Quality Improvement Funding was used to help provide quaility service to 459 children in Durham, NC area. The funding helped to improve the safety and quailty of playgrounds, provide better bus transportation, improve the structu Administration for Children and Families 6/30/2009
DUKE UNIVERSITY $226,289 Trans-NIH Recovery Act Research Support With funding from a pilot project from the Harvard Center for Medical Countermeasures against Radiation, we have utilized sophisticated mouse genetics to determine the role of the intrinsic pathway of apoptosis in the acute radiation syndrome. Through the National Institutes of Health 7/22/2009
DUKE UNIVERSITY $225,036 Trans-NIH Recovery Act Research Support Apoptosis is a program of cellular suicide that leads to the elimination of individual cells from the midst of a living tissue without damaging overall tissue architecture. Many stimuli, both extracellular and intracellular impact the cellular decision to National Institutes of Health 9/16/2009
HAMNER INSTITUTES, THE $225,000 Trans-NIH Recovery Act Research Support The support from this award will allow continued investigation of fat cell metabolism in response to adrenaline and promote understanding of new intracellular pathways that may be able to be targeted for managment of obestiy and metabolic disease National Institutes of Health 9/18/2009
RESEARCH TRIANGLE INSTITUTE $224,627 RTI is to provide a wide variety of statistical programming and basic data analysis services to support the implementation of a national warehouse of state quitline data to facilitate evaluation and program improvement. These services include data proce Centers for Disease Control and Prevention 3/15/2010
DUKE UNIVERSITY $221,402 Trans-NIH Recovery Act Research Support The biological functions of DNA, including replication, transcription, recombination and repair, require unwinding and rewinding of the intertwined duplex. DNA topoisomerases are the essential enzymes to facilitate these processes. Besides their ubiquitou National Institutes of Health 8/13/2009
NORTH CAROLINA CENTRAL UNIVERSITY $220,272 Trans-NIH Recovery Act Research Support The goal is to increase the research productivity of the project, by providing additional fund to hire a research associate that was partially funded in the parent proposal, and to provide vital multiuser equipments that would facilitate the implementatio National Institutes of Health 9/15/2009
MDB, INC. $219,920 Conduct analysis of research advances as reported by the ARRA-funded grant supplements; modify, update and maintain the NIEHS SRP data system to incorporate ARRA-funded grant outcomes; and develop web content and other printed materials describing the ARR
This spending item is part of a $227,940 allocation. See details
National Institutes of Health 10/01/2009
DUKE UNIVERSITY $217,264 Trans-NIH Recovery Act Research Support This application addresses Challenge Area #15:Translational Science and Specific Challenge Topic, 15-HD-102: Pelvic Pain. We propose to characterize the pain with menses and noncyclic pelvic pain in women with uterine leiomyomas at baseline and following
This spending item is part of a $974,131 allocation. See details
National Institutes of Health 9/30/2009
RESEARCH TRIANGLE INSTITUTE $212,929 Trans-NIH Recovery Act Research Support This study will analyze Medicaid administrative data from four states collected between 1999 to 2004 to: (1) assess the usefulness of this data to compare special needs populations with oral and pharyngeal cancers; (2) generate descriptive statistics on t National Institutes of Health 5/05/2009
RESEARCH TRIANGLE INSTITUTE $212,181 Trans-NIH Recovery Act Research Support The hypotheses of our original application are: (a) nAChR partial agonists possessing high affinity for nAChRs and varying degrees of agonist and antagonist efficacies and nAChR subtype selectivity will be useful pharmacological tools for studying the nA National Institutes of Health 9/21/2009
DUKE UNIVERSITY $204,998 Trans-NIH Recovery Act Research Support One of the most influential findings of the last 20 years in molecular evolutionary studies has been that recombination rate is frequently correlated with nucleotide sequence diversity within a species. In Drosophila species, this relationship has been at National Institutes of Health 9/09/2009
DUKE UNIVERSITY $203,942 Trans-NIH Recovery Act Research Support Success of modern epidemiological investigations into complex disease and, in particular, success of the Genes and Environment Initiative (GEI) will depend on development of methods that address these challenges and on their efficient, open source impleme National Institutes of Health 7/16/2009
SCYNEXIS, INC. $200,000 Trans-NIH Recovery Act Research Support The funds provided by this Revision grant are being used to accelerate the development of a novel clinical candidate for the treatment of osteoarthritis (OA), a disease that currently affects 22% of the US population but has no effective treatment. We wi
This spending item is part of a $334,600 allocation. See details
National Institutes of Health 9/29/2009
RIDGE DIAGNOSTICS, INC. $200,000 Trans-NIH Recovery Act Research Support USING A BIOMARKER PANEL FOR DETECTING ADOLESCENT DEPRESSION: Approximately 6% of all U.S. teenagers suffer from clinical depression which is known to result in continued risk for recurrences with persistence of depressive episodes and psychosocial morbidi National Institutes of Health 7/27/2010
DUKE UNIVERSITY $199,961 Trans-NIH Recovery Act Research Support Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial. Identification of children at high risk to
This spending item is part of a $281,653 allocation. See details
National Institutes of Health 9/25/2009
DUKE UNIVERSITY $193,936 Trans-NIH Recovery Act Research Support Collaboration between Duke SBRC Project 6, Developmental Effects of Superfund Hydrocarbon Mixtures in Fundulus heteroclitus (Richard Di Giulio, PI) and University of North Carolina, Chapel Hill SBRC Project 1, The Role of Oxidative Stress in Toxicity and National Institutes of Health 9/06/2009
DUKE UNIVERSITY $191,046 Trans-NIH Recovery Act Research Support Uropathogenic Escherichia coli is the leading cause of urinary tract infections (UTIs), resulting in annual health care costs of >$2.5 billion in the US alone. Our long term objective is to elucidate key pathways in the pathogenesis of UTI that may be am National Institutes of Health 8/16/2010
DUKE UNIVERSITY $180,716 Trans-NIH Recovery Act Research Support We have designed a training program for PhD students in Bioinformatics, Genome Technology and Computational Biology. Once it became apparent that modern biology would be increasingly dependent on quantitative methods, several approaches to training arose, National Institutes of Health 8/03/2009
RESEARCH TRIANGLE INSTITUTE $180,652 Trans-NIH Recovery Act Research Support This study will be the first we are aware of to estimate the influence of peers on adolescent weight-related behavior that also controls for alternative, co-occurring reasons. Study results will be used to develop and improve public health policies need National Institutes of Health 9/08/2009
DUKE UNIVERSITY $180,576 Increasing Adoption of Early Intervention to Prevent Diabetes After Gestational DM
This spending item is part of a $1,999,917 allocation. See details
National Institutes of Health 8/18/2010
RESEARCH TRIANGLE INSTITUTE $179,524 ARRA - Prevention and Wellness--State Territories and Pacific Islands Under Component II, the DCDIP proposes to educate leaders and decision-makers about, and promote the effective implementation of, nutrition initiatives and will include evaluation to assess and document the public health impact an... Show more
This spending item is part of a $3,000,000 allocation. See details
Centers for Disease Control and Prevention 2/06/2010
DUKE UNIVERSITY $176,177 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (04) Clinical Research and Specific Challenge Topic, 04-DA-102: A New Look at Longitudinal Data. Despite decades of research on the etiology, prevention and treatment of substance use disorders, scientific i
This spending item is part of a $857,440 allocation. See details
National Institutes of Health 9/21/2009
DUKE UNIVERSITY $175,714 Trans-NIH Recovery Act Research Support Infections caused by Staphylococcus aureus span a wide clinical spectrum, ranging from asymptomatic nasal carriage to endocarditis, bone and joint infections and lethal shock. Increasing rates of S. aureus infection and the emergence of community-acquired
This spending item is part of a $558,617 allocation. See details
National Institutes of Health 9/21/2009
DUKE UNIVERSITY $174,778 Trans-NIH Recovery Act Research Support Millions of Americans develop chest pain suggestive of coronary heart disease each year and often require non-invasive diagnostic testing. However, currently available tests are imprecise, robust evidence regarding optimal test choice is limited, and test
This spending item is part of a $2,801,921 allocation. See details
National Institutes of Health 9/29/2009
DUKE UNIVERSITY $171,547 Trans-NIH Recovery Act Research Support In response to NOT-OD-09-056, we request an administrative supplement to R01 HG004065, ?Modeling the structure & evolution of regulatory regions in eukaryotic genomes?. Transcriptional control is undoubtedly one of the important aspects of gene expression National Institutes of Health 9/10/2009
RESEARCH TRIANGLE INSTITUTE $170,436 Trans-NIH Recovery Act Research Support Adequate housing is a fundamental human right. However, the limited research that has been conducted demonstrates that inadequate housing is the most basic of all of the unjust and inequitable conditions that farmworkers in North Carolina and the southeas
This spending item is part of a $1,783,650 allocation. See details
National Institutes of Health 9/03/2009
DUKE UNIVERSITY $169,650 Trans-NIH Recovery Act Research Support Human cancers are extremely heterogeneous. Integrative cancer systems biology must develop more comprehensive and incisive methods to interrogate various sources of heterogeneity, and to rationally represent their complex interactions in refined predictiv National Institutes of Health 9/16/2009
DUKE UNIVERSITY $167,082 To design and test a method of intervention that has the capacity to promote engagement and adherence to treatment, foster recovery and reduce or prevent disability in patients experiencing a first episode of schizophrenia and related psychotic disorders.
This spending item is part of a $10,496,230 allocation. See details
National Institutes of Health 7/13/2009
DUKE UNIVERSITY $156,820 Trans-NIH Recovery Act Research Support The overall objective is to define the Ca2+-dependent signaling pathway in hypothalamic neurons that regulates appetite and body weight to provide novel insights to human obesity. AMPK, originally discovered to protect cells against stresses that deplete National Institutes of Health 5/04/2010
DUKE UNIVERSITY $156,072 Trans-NIH Recovery Act Research Support During my current grant period, we showed that sex determination depends on the antagonism between two opposing signaling pathways, FGF9 and WNT4. Genetic background affects the phenotype of both Fgf9 and Wnt4 mutants, indicating that the balance between National Institutes of Health 9/28/2009
DUKE UNIVERSITY $156,000 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) treats the cardinal symptoms of Parkinson's disease (PD) including bradykinesia, rigidity, and tremor, and the efficacy of DBS is strongly dependent on finding stimulation parameters (fr National Institutes of Health 9/25/2009
DUKE UNIVERSITY $156,000 Trans-NIH Recovery Act Research Support During embryonic development, a single-layered ectodermal cell layer transforms into a multi- layered epidermis. The multi-layered or stratified architecture of the epidermis is essential for its barrier function - allowing it to prevent both dehydration National Institutes of Health 7/17/2009
DUKE UNIVERSITY $156,000 Trans-NIH Recovery Act Research Support The goal of this R03 proposal is to identify molecular mechanisms underlying the regulation of inhibitory synaptic transmission by the cell adhesion molecule (CAM) neuroligin 2 (NL2). Although it has been established that neuroligins mediate synaptogenic National Institutes of Health 7/16/2009
DUKE UNIVERSITY $154,850 Trans-NIH Recovery Act Research Support Our lab studies genotype by sex interaction in the etiology of metabolic traits, including dsylipidemia and diabetes. Through our work on the high density lipoprotein receptor, scavenger receptor class B type 1 (SR-BI), we have identified two distinct pol National Institutes of Health 7/16/2009
DUKE UNIVERSITY $154,434 Trans-NIH Recovery Act Research Support The overarching goal of the parent project was to identify lifestyle factors and potential epigenetic mechanisms associated with rapid growth and subsequent obesity in early childhood. Epigenetic factors are mitotically heritable information that controls National Institutes of Health 9/14/2009
DUKE UNIVERSITY $151,757 Trans-NIH Recovery Act Research Support Religent, along with the Duke University Medical Center, is developing a Web Service (SEBASTIAN) that will provide clinical decision support to routine clinical practices using a standards-based approach. A component of this is the Decision Engine (DE) wh
This spending item is part of a $249,037 allocation. See details
National Institutes of Health 7/22/2009
RESEARCH TRIANGLE INSTITUTE $150,589 Trans-NIH Recovery Act Research Support This award was funded to support 1 full time employee and 1 part time graduate-level intern in the field of public health research. The positions will be assigned to assist in the implementation of ongoing HIV research activities to support the collection National Institutes of Health 6/14/2010
DUKE UNIVERSITY $150,547 Trans-NIH Recovery Act Research Support The ultimate goal of this proposal is to identify biomarkers that can determine which patients presenting with non-small cell lung cancer (NSCLC) have metastasis. While some patients present with overt metastatic disease, others may have more subtle metas National Institutes of Health 8/31/2009
MDB, INC. $150,000 Initial Pay Line Module; Program Officer Assessment; Reviewer Assignment Module; Editorial Review Module; Completion of Review and Final Awards; Auditing and Reports. Create or modify an existing database to track ARRA grant money for the Worker Educatio National Institutes of Health 6/30/2009
DUKE UNIVERSITY $149,904 Trans-NIH Recovery Act Research Support Encouraged by its success, the NIDDK has issued RFA-DK-08-505 whose objective is to continue the NASH CRN for additional five years. The objectives of the NASH CRN during the next funding period are (a) to successfully complete three network-v'de studies National Institutes of Health 1/25/2010
DUKE UNIVERSITY $145,790 Trans-NIH Recovery Act Research Support Primary Hyperoxaluria type I (PH1) is a severe kidney stone disease caused by deficiency of the protein alanine: glyoxylate aminotransferase (AGT). In many patients, deficiency of AGT results from missense mutations that decrease the stability of this enz National Institutes of Health 9/21/2009
DUKE UNIVERSITY $144,871 Trans-NIH Recovery Act Research Support Nontypable Haemophilus influenzae is an important human pathogen and represents the leading cause of both acute otitis media and otitis media with effusion, conditions associated with deficiencies in language acquisition, speech development, and school pe National Institutes of Health 7/17/2009
DUKE UNIVERSITY $144,321 Trans-NIH Recovery Act Research Support Cryptococcus neoformans is one of the most common life-threatening central nervous system infections in humans and despite present treatments, morbidity and mortality still remain high. In a recent outbreak on Vancouver Island, British Columbia it was sho National Institutes of Health 7/06/2010
DUKE UNIVERSITY $142,816 Trans-NIH Recovery Act Research Support This country lacks a cohesive, informative surveillance system for vascular disease that can provide insights into national patterns of stroke and reveal national trends over time. Stroke is a major public health problem in the United States. It is the th
This spending item is part of a $960,956 allocation. See details
National Institutes of Health 9/25/2009
RESEARCH TRIANGLE INSTITUTE $142,552 Trans-NIH Recovery Act Research Support This project will provide results on an experimental approach to the reduction of bias and variance in survey estimates. If successful, less data could be collected while providing more accurate results.
This spending item is part of a $211,133 allocation. See details
National Institutes of Health 9/27/2010
DUKE UNIVERSITY $142,500 ARRA ? Equipment to Enhance Training for Health Professionals The specific goal and objective of the proposed equipment purchase is to acquire two ?Harvey? cardiopulmonary patient simulators with sound transmission systems, to enhance the PA Program?s utilization of this simulator model. The PA Prog... Show more Health Resources and Services Administration 9/04/2010
DUKE UNIVERSITY $142,141 Trans-NIH Recovery Act Research Support Sickle cell anemia is a devastating disease affecting primarily African Americans. Our goals are to capture the genetic diversity that is likely to underlie the notoriously heterogeneous clinical course of this disease, and with this information, develop
This spending item is part of a $2,981,256 allocation. See details
National Institutes of Health 9/28/2009
DUKE UNIVERSITY $140,545 The Systolic Blood Pressure Intervention Trial (SPRINT)-Senior ARRA expansion is designed to test the SPRINT intervention in participants who are ? 75 years of age. Approximately 3,250 of the 9,250 SPRINT participants are expected to be age 75 or older. I
This spending item is part of a $2,671,616 allocation. See details
National Institutes of Health 9/24/2010
DUKE UNIVERSITY $137,589 Trans-NIH Recovery Act Research Support Nasally administered vaccines have the potential to be effective, economical, needle-free methods of immunization able to induce both systemic and'mucosal immunity. Nasal immunization may allow for safe and effective vaccination against emerging infectiou National Institutes of Health 5/10/2010
DUKE UNIVERSITY $134,951 Trans-NIH Recovery Act Research Support The overall objective of this competing R01 renewal is the continued development of the Elastin Fusion Protein technology as a genetically encodable, biomimetic analog of -smart protein-polymer conjugates. The overall objective is motivated by the rationa National Institutes of Health 7/17/2009
DUKE UNIVERSITY $134,204 Trans-NIH Recovery Act Research Support Accumulating evidence suggests that podocyte depletion is a final common pathway causing progressive loss of kidney function characteristic of glomerular disease processes. In response to the Program Announcement (PA-07-012) entitled, Animal models of NID National Institutes of Health 12/07/2009
DUKE UNIVERSITY $133,600 Trans-NIH Recovery Act Research Support Cardiac tissue injury during myocardial infarction often leads to congestive heart failure. The field of tissue engineering offers the promise of generating a muscle patch that would structurally and functionally repair tissue damage resulting from infarc National Institutes of Health 7/16/2009
DUKE UNIVERSITY $132,853 Trans-NIH Recovery Act Research Support No large-scale study within the United States has examined any aspect of the epidemiology of intracranial meningiomas, a lesion which accounts for up to 25% of all primary intracranial neoplasms. We propose to conduct a population-based case/control study National Institutes of Health 9/25/2009
DUKE UNIVERSITY $129,897 Trans-NIH Recovery Act Research Support The primay goal of the parent grant is development of innovations in shock wave lithotripsy (SWL) technology. In the past two years, we have completed a series of experiments aiming at comparison of the characteristics of acoustic field, stone comminution National Institutes of Health 11/19/2009
DUKE UNIVERSITY $129,897 Trans-NIH Recovery Act Research Support The primay goal of the parent grant is development of innovations in shock wave lithotripsy (SWL) technology. In the past two years, we have completed a series of experiments aiming at comparison of the characteristics of acoustic field, stone comminution National Institutes of Health 11/19/2009
DUKE UNIVERSITY $126,958 Trans-NIH Recovery Act Research Support Impairments in visual-auditory integration impact numerous aspects of human health, ranging from communication and language to attention and movements in a complicated environment. Previously, such deficits were believed to involve higher brain structures National Institutes of Health 9/30/2009
DUKE UNIVERSITY $125,161 Trans-NIH Recovery Act Research Support FtsZ, a homolog of tubulin, is the major cytoskeletal protein in bacterial cell division. It assembles into protofilaments that are ~30 subunits (120 nm) long. In vivo these protofilaments are further assembled into a Z ring, which encircles the cell at m National Institutes of Health 9/11/2009
DUKE UNIVERSITY $123,468 Trans-NIH Recovery Act Research Support Project Title: A Six-Month, RCT of Probuphine Safety and Efficacy in Opioid Addiction. We are conducting a six-month, randomized, placebo and active-controlled, multicenter clinical trial of Probuphine in patients with opioid dependence for the purpose
This spending item is part of a $7,586,848 allocation. See details
National Institutes of Health 9/30/2009
THUNDERCAT TECHNOLOGY, LLC $120,601 NetApp DS14A-R5 Shelf Model/Cabinet/Drives. System includes all the components. National Institutes of Health 6/02/2010
EXECUTIVE OFFICE OF THE STATE OF NORTH CAROLINA $119,193 Aging Home-Delivered Nutrition Services for States ARRA provided funding for Home-Delivered Nutrition Services. Established in 1978 under the Older Americans Act, the program provides meals to seniors who are homebound.
This spending item is part of a $913,413 allocation. See details
Administration on Aging 3/18/2009
DUKE UNIVERSITY $118,828 Trans-NIH Recovery Act Research Support Unrepaired DNA damage is an important source of mutations, and such mutations are assumed to reflect error-prone lesion bypass during DNA replication. Although DNA damage-associated mutations also arise in nondividing (G0) cells, their mechanistic basis h National Institutes of Health 12/25/2009
DUKE UNIVERSITY $117,744 Trans-NIH Recovery Act Research Support The injured human heart has an extremely limited ability to repair itself through regeneration of cardiomyocytes.By contrast with mammals, we found a few years ago that the teleost zebrafish displays a highly efficient regenerative response to cardiac inj National Institutes of Health 7/16/2009
DUKE UNIVERSITY $115,689 Trans-NIH Recovery Act Research Support Trabecular meshwork cells are known to be actively phagocytic; they are capable of ingesting endogenous and exogenous material, thus keeping the trabecular outflow channels free of potentially obstructive debris. During the experimental phase of SA.1 of t National Institutes of Health 9/16/2009
DUKE UNIVERSITY $115,006 Trans-NIH Recovery Act Research Support Drugs of abuse are metabolized by the cells of the body including macrophages and leukocytes. Macrophages are primarily responsible for the detection, phagocytosis and digestion of toxins in the bloodstream and peripheral tissues. Normal cellular metabol
This spending item is part of a $2,661,005 allocation. See details
National Institutes of Health 9/30/2009
MDB, INC. $115,000 Develop separate tracking, monitoring and reporting modules in order to track trainees placed in jobs supported by ARRA supplemental health and safety training. Develop a communication pathway with the Worker Education and Training Branch (WETB) ARRA gra National Institutes of Health 7/28/2009
DUKE UNIVERSITY $114,846 Trans-NIH Recovery Act Research Support The Duke University Medical Center (DUMC) Clinical Trials Unit (CTU) proposes to address the key scientific areas of translational research and optimization of clinical management in children and adults, and prevention of mother to child transmission.The National Institutes of Health 2/26/2010
DUKE UNIVERSITY $113,015 Trans-NIH Recovery Act Research Support This award is issued under the American Recovery and Reinvestment Act of 2009 and is subject to special HHS terms and conditions as referenced in Section III.
This spending item is part of a $999,931 allocation. See details
National Institutes of Health 9/30/2009
DUKE UNIVERSITY $112,504 Trans-NIH Recovery Act Research Support The aims of the ENCODE (Encyclopedia of DNA Elements) and modENCODE (model organism ENCODE) projects are to apply high-throughput, cost-efficient approaches to generate a catalog of functional elements in the human, worm, and fly genomes, which will serve
This spending item is part of a $2,789,724 allocation. See details
National Institutes of Health 9/30/2009
DUKE UNIVERSITY $110,401 Trans-NIH Recovery Act Research Support In humans with diabetes, abnormal angiogenesis contributes to the development of end-organ damage. In this regard, excessive angiogenesis and increased activity of the vascular endothelial growth factor (VEGF) signaling pathway have been associated with d National Institutes of Health 9/04/2009
DUKE UNIVERSITY $108,000 Trans-NIH Recovery Act Research Support The Duke Global health Institute (DGHI) Framework program is developing a new Master of Science in Global health (MSc-GH). This supplement will be used to develop online learning modules based on selected course content from this program and incorporate National Institutes of Health 9/03/2009
DUKE UNIVERSITY $108,000 Trans-NIH Recovery Act Research Support Described below is an administrative supplemental request for an actively funded K08 grant entitled Non Muscle Myosin II Contractility Putatively Regulates Scar Contracture. This proposal has been devised based on the goals of the NIGMS-Specific Requireme National Institutes of Health 9/30/2009
DUKE UNIVERSITY $108,000 Trans-NIH Recovery Act Research Support Described below is an administrative supplemental request for an actively funded K08 grant entitled Non Muscle Myosin II Contractility Putatively Regulates Scar Contracture. This proposal has been devised based on the goals of the NIGMS-Specific Requireme National Institutes of Health 9/30/2009
DUKE UNIVERSITY $105,520 Trans-NIH Recovery Act Research Support Approaches to therapeutic intervention for food allergies include the prevention of food allergy and the treatment with immunotherapy for an individual with an established allergy [1]. In this proposal, both of these interventions will be developed for ca National Institutes of Health 7/17/2009
DUKE UNIVERSITY $104,939 Trans-NIH Recovery Act Research Support Several lines of evidence suggest amino acid neurotransmitter system abnormalities contribute to the neurobiology of depression. In humans, there is clear evidence of altered amino acid neurotransmitter function in depressed individuals. Most notably, dep
This spending item is part of a $135,494 allocation. See details
National Institutes of Health 7/16/2009
NORTH CAROLINA CENTRAL UNIVERSITY $104,681 Trans-NIH Recovery Act Research Support Mechanisms Underlying Drug-Diet Interactions - Administrative Supplement Milk thistle is a top 10 selling dietary supplement used to self-treat hepatic disorders and for chemoprevention. The two most common commercial preparations are termed ?silymarin? a
This spending item is part of a $342,592 allocation. See details
National Institutes of Health 7/17/2009
DUKE UNIVERSITY $104,647 Trans-NIH Recovery Act Research Support Aim S1: One litter of Y17 H-chain-only Tg mice have been bred and initial phenotyping is in progress, using flow cytometry, cell culture, and ELISA assays. We anticipate preliminary data from this experiment will be available within the next two weeks. National Institutes of Health 9/24/2009
DUKE UNIVERSITY $103,522 Trans-NIH Recovery Act Research Support Urinary tract infections (UTIs) represent one of the most common bacterial infections of humans. Recurrence and persistence of UTIs, in spite of appropriate antibiotic therapry, has been attributed, at least in part, to the pathogen seeking intracellular National Institutes of Health 9/17/2009
DUKE UNIVERSITY $101,400 Trans-NIH Recovery Act Research Support We have previously identified a point mutation in thes Transient Receptor Potential Cation Channel 6 (TRPC6) gene causing an autosomal dominant form of familial focal and segmental glomerulosclerosis (FSGS). This P112Q substitution causes a marked alterat National Institutes of Health 9/25/2009
DUKE UNIVERSITY $100,001 Trans-NIH Recovery Act Research Support Human red blood cell (erythrocyte) diseases, including anemia and malaria, pose a huge burden for the human race. Our understanding of these diseases is rather limited. For example, while the genetic cause of sickle cell diseases (SCD) and the positive se National Institutes of Health 3/12/2010
DUKE UNIVERSITY $100,000 Trans-NIH Recovery Act Research Support The goal of this project is to increase recruitment and retention of underrepresented and underserved populations into AIDS Clinical Trials Group (ACTG) clinical trials. The ACTG is committed to enrollment of domestic clinical trial participants in propor
This spending item is part of a $1,130,883 allocation. See details
National Institutes of Health 9/21/2009
DUKE UNIVERSITY $100,000 Trans-NIH Recovery Act Research Support Hedgehog signaling plays critical roles in development and the maintenance of stem cells, but is also reactivated during normal and pathological wound healing processes. The secreted Hedgehog ligands Sonic Hedgehog (SHhg) and Indian Hedgehog (IHhg) bind t National Institutes of Health 9/16/2009
DUKE UNIVERSITY $99,999 Trans-NIH Recovery Act Research Support E.coli induced Urinary tract infections (UTIs) constitute one of the most common bacterial infections of man. Because of the recurrence of UTIs in infected patients and the growing resistance of E.coli to antibiotics, there is great interest in developing National Institutes of Health 11/19/2009
DUKE UNIVERSITY $98,742 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Over one million Americans will suffer from cancer every year, and approximately half of them will die from the disease. Despite major efforts to prevent cancer, effective early diagnosis and treatment of non- metastat National Institutes of Health 9/28/2009
DUKE UNIVERSITY $98,550 Trans-NIH Recovery Act Research Support In this proposal we propose to extend our prior observations that stromal cell lines can influence the outcome of HSC fate by controlling the ratio of asymmetric and symmetric division, and test whether primary bone marrow stromal cells also influence asy National Institutes of Health 11/18/2009
DUKE UNIVERSITY $98,516 Trans-NIH Recovery Act Research Support Prevention of child and adult obesity is a national public health priority. Optimal interventions would target young children and their overweight parents to capitalize on the formation of healthy eating habits and increased physical activity in the child National Institutes of Health 8/14/2009
DUKE UNIVERSITY $98,012 Trans-NIH Recovery Act Research Support The broad long-term goal of this administrative supplement funded project is: We will improve our understanding of the emergence of S. cerevisiae as an opportunistic pathogen via analysis of a novel genetically complex virulence trait, the ability to grow National Institutes of Health 8/13/2009
GLOBAL VACCINES INC $97,684 Trans-NIH Recovery Act Research Support Effect of a viral replicon adjuvant on dendritic cell activity. It has been demonstrated in this lab that infectious, non-propagating replicon particles from Venezuelan equine encephalitis virus (VEE) act as an adjuvant when co-delivered parenterally wit National Institutes of Health 6/04/2009
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $96,798 Trans-NIH Recovery Act Research Support The CFAR Network of Integrated Clinical Systems (CNICS), headquartered at UAB, was funded in September 2006 via the R24 mechanism. This supplement is to fund increased capacity for sample repositorys at UAB and each of the designated CNICS sites through
This spending item is part of a $1,825,789 allocation. See details
National Institutes of Health 9/21/2009
DUKE UNIVERSITY $96,367 Trans-NIH Recovery Act Research Support Cilia are ancient organelles present in most eukaryotic cells. Recent studies have shown that ciliarydysfunction leads to a multitude of clinical phenotypes, collectively termed the ciliopathies. Studies byour group and others have shown that mutations in National Institutes of Health 9/29/2010
RESEARCH TRIANGLE INSTITUTE $93,284 Trans-NIH Recovery Act Research Support The aim overall of this application is to enhance capacity to perform early developmental interventions and neurodevelopmental assessments in order to conduct collaborative research that will evaluate a program of early developmental intervention to reduc
This spending item is part of a $222,039 allocation. See details
National Institutes of Health 9/30/2009
GLOBAL VACCINES INC $92,824 Trans-NIH Recovery Act Research Support The goal of our proposal is to understand how alphavirus replicon particles (nVRPs) function as adjuvants. nVRPs stimulate a protective systemic and mucosal immune response when co-delivered with a target antigen even when delivered at a non-mucosal site. National Institutes of Health 6/04/2009
NORTH CAROLINA CENTRAL UNIVERSITY $92,396 Trans-NIH Recovery Act Research Support The overall goal is to explore a two-step proteomics screen to identify genome wide metastable epialleles that may be influenced by milk thistle nutritional supplements. National Institutes of Health 9/15/2011
DUKE UNIVERSITY $92,153 Trans-NIH Recovery Act Research Support Rheumatoid arthritis (RA) is the most common type of inflammatory arthritis; while there are now many effective medications to treat it, these drugs vary greatly in cost (up to $15,000/year) and side effects and there is no way to predict which drug is be
This spending item is part of a $3,344,252 allocation. See details
National Institutes of Health 9/29/2009
DUKE UNIVERSITY $89,347 Trans-NIH Recovery Act Research Support In the approved parent grant, we proposed three specific aims, the completion of which would define the role of ERR? in breast cancer, and enhance our understanding of ERR? biology. We have now completed Aim 1 and demonstrated that ERR? activity is funct National Institutes of Health 2/04/2010
DUKE UNIVERSITY $87,655 Trans-NIH Recovery Act Research Support The cerebellum is critical for motor coordination and cognitive function. Granule neurons are a key component of cerebellar circuitry and are thought to represent the cell of origin for the pediatric brain tumor medulloblastoma. While the development of g National Institutes of Health 9/15/2009
DUKE UNIVERSITY $87,430 Trans-NIH Recovery Act Research Support The purpose of this administrative supplement request is to enhance our mouse model systemresearch into the mechanisms of craniofacial and foregut birth defects. Recent research from our ownlab and others has led to the surprising realization that the for National Institutes of Health 3/08/2010
DUKE UNIVERSITY $87,137 The Cancer Human Biobank (caHUB) - This is a national, standardized , biospecimen resource for the collection of human tissues which are a critical resource for cancer research. Contracts will be established with medical research adn healthcare entities
This spending item is part of a $60,000,000 allocation. See details
National Institutes of Health 9/04/2009
DUKE UNIVERSITY $82,556 Trans-NIH Recovery Act Research Support As people get older, they confront a variety of negative life events, including physical and mental changes and the loss of social relationships. In spite of these changes, many older adults maintain relatively high subjective well-being, raising question National Institutes of Health 8/14/2009
DUKE UNIVERSITY $79,649 Trans-NIH Recovery Act Research Support The biggest challenge in fighting the obesity epidemic is developing better ways to help individuals that have lost weight maintain their weight loss over many years. This challenge grant provides funding to analyze follow-up data collected 2 -+ years fo
This spending item is part of a $996,603 allocation. See details
National Institutes of Health 9/23/2009
DUKE UNIVERSITY $78,909 Trans-NIH Recovery Act Research Support This supplemental effort would take advantage of an exciting collaborative opportunity to cap off the aims and accomplishments of the parent grant, while providing a major service to the biological and biomedical research communities and a job to a talent National Institutes of Health 9/30/2009
DUKE UNIVERSITY $78,000 Trans-NIH Recovery Act Research Support NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Application The immune system has the potential to eliminate altered neoplastic cells with incredible specificity. A consistent in-frame deletion in the extra-cel National Institutes of Health 9/29/2009
DUKE UNIVERSITY $75,435 Trans-NIH Recovery Act Research Support Since this application was submitted in 2006, the 2D-PAGE proteomic methodologies proposed to define the biology of Lipid Droplets have been surpassed by far more sensitive and comprehensive tandem MS/MS approaches. These new machines and technologies are National Institutes of Health 8/11/2009
COMPASS EVALUATION AND RESEARCH, INC. $75,000 ARRA Child Care and Development Block Grant ARRA DISCRETIONARY FUNDING FOR CHILD CARE DEVELOPMENT - Grants for states, territories, tribes and tribal organizations for child care assistance for low income working families and fund activities to improve the quality of child care.
This spending item is part of a $5,747,006 allocation. See details
Administration for Children and Families 4/09/2009
DUKE UNIVERSITY $75,000 To establish a coordinated process structured to meet previously-identified scientific needs for quantitative imaging biomarkers. The long-term objective is to establish processes and profiles that will lead to acceptance by the imaging community, clinica
This spending item is part of a $2,412,566 allocation. See details
National Institutes of Health 9/30/2010
DUKE UNIVERSITY $74,071 Trans-NIH Recovery Act Research Support Progress in biomedical research and its translation into clinical practice require the integration of data across multiple scales (molecules, cells, organisms), organism types, and fields of research. The need for data integration is especially acute in i National Institutes of Health 9/21/2009
DUKE UNIVERSITY $73,415 Trans-NIH Recovery Act Research Support Chromosome 22q11.2 deletion syndrome is the most common chromosome microdeletion syndrome in human beings and results in multiple medical problems and neurocognitive deficits. These neurocognitive deficits adversely affect functions that are critical to t National Institutes of Health 9/24/2010
DUKE UNIVERSITY $73,411 Trans-NIH Recovery Act Research Support Our current grant, 5R01ES15829-2 G?Measuring Human Exposure to PBDEsG? is assessing PBDEs at multiple steps of the exposure-response continuum. We are characterizing potential PBDE sources (consumer products), key microenvironments (dust from home, workp
This spending item is part of a $371,436 allocation. See details
National Institutes of Health 9/06/2009
DUKE UNIVERSITY $72,322 Trans-NIH Recovery Act Research Support Patient recruitment and retention Patient recruitment and retention of study subjects has been excellent in this study. The COMET Network was able to screen 108 potential subjects. From these there were 12 screen fails, 3 subjects withdrew consent, two
This spending item is part of a $7,915,507 allocation. See details
National Institutes of Health 9/28/2009
DUKE UNIVERSITY $70,900 Trans-NIH Recovery Act Research Support Supplemental funds ($90,620) are requested to accelerate the pace of this award. The supplemental funds requested do not involve a change in scope of the project, but will accelerate the pace of our studies by allowing us to work more efficiently. They ar National Institutes of Health 9/30/2009
DUKE UNIVERSITY HEALTH SYSTEM, INC. $68,314 Trans-NIH Recovery Act Research Support In our proposed research we will develop a novel approach for magnetically-driven organization of ordered cellular structures without using microfabricated substrates, potentially harmful electrical fields, or the physical attachment to or uptake of mater
This spending item is part of a $235,078 allocation. See details
National Institutes of Health 7/16/2009
RESEARCH TRIANGLE INSTITUTE $67,791 Trans-NIH Recovery Act Research Support ARRA - TRANS-NIH RECOVERY ACT RESEARCH SUPPORT - MDMA (G?EcstasyG?) is a popular drug of abuse especially among youth in the population. Use of MDMA is associated with acute physiological effects among which is the development of hyperthermia, which in tu
This spending item is part of a $406,791 allocation. See details
National Institutes of Health 7/16/2009
DUKE UNIVERSITY $67,510 Trans-NIH Recovery Act Research Support The prevalence of food allergy has increased over the past 2 decades and food allergy now affects 3.5% :o 4% of the U.S. population. Peanut allergy, which is the single leading cause of severe and fatal foodnduced allergic reactions in the U.S., affects 1
This spending item is part of a $372,330 allocation. See details
National Institutes of Health 7/19/2010
DUKE UNIVERSITY $67,025 Trans-NIH Recovery Act Research Support The Fogarty International Clinical Research Scholars & Fellows Support Center @ Vanderbilt University G?? Association of American Medical Colleges (FICRS?F) requests an administrative increase for the Fogarty International Clinical Research Scholars Suppo
This spending item is part of a $3,000,000 allocation. See details
National Institutes of Health 6/20/2009
DUKE UNIVERSITY $64,817 Trans-NIH Recovery Act Research Support This proposal is for a Rare Cancer Genetics Registry (RCGR). The proposal is being submitted for Challenge Area: 07: Enhancing Clinical Trials and specific Challenge Topic: Rare Disease Genetic Patient Registry: 07-OD(ORDR)-102. We will develop a registry
This spending item is part of a $987,770 allocation. See details
National Institutes of Health 9/29/2009
DUKE UNIVERSITY $64,552 Trans-NIH Recovery Act Research Support The leading cause of disability in the U.S.is arthritis, affecting approximately 60% of those over 65 years of age. Biomedical treatments are limited in their ability to curb osteoarthritis (OA) disease progression and to eliminate pain and functional imp
This spending item is part of a $606,241 allocation. See details
National Institutes of Health 9/21/2009
TECAN US INC. $63,453 Sequencer, Freedom EVO 75 SOLID Library Prep National Institutes of Health 9/22/2010
INSTITUTE FOR MEDICAL RESEARCH, INC. $63,000 Trans-NIH Recovery Act Research Support The Coordinating and Bioinformatics Unit (CBU) for the Animal Models of Diabetic Complications Consortium (AMDCC) and the Mouse Metabolic Phenotyping Centers (MMPC) is responsible for creating and maintaining the administrative, scientific and informatics
This spending item is part of a $1,819,749 allocation. See details
National Institutes of Health 9/28/2009
DUKE UNIVERSITY $62,244 Trans-NIH Recovery Act Research Support Diabetes is a common and costly disease with severe complications. Despite evidence that tight control of blood sugar prevents complication, only about 40% of patients with diabetes have adequate blood sugar control. Approximately 75% of all patients with National Institutes of Health 8/06/2010
RESEARCH TRIANGLE INSTITUTE $62,066 Trans-NIH Recovery Act Research Support Stimulant abuse (including both cocaine and amphetamines) is a serious public health problem. There are thought to be over 3 million current users of these drugs in the United States, and these drugs account for numerous emergency room visits each year. A
This spending item is part of a $418,403 allocation. See details
National Institutes of Health 5/14/2009
NORTH CAROLINA CENTRAL UNIVERSITY $61,969 ARRA - Scholarships for Disadvantaged Students The purpose of the SDS award is to provide scholarships for students that need financial assistance to continue their education. Preference for this scholarship will be given to nursing students from whom the cost of attendance to the university would ... Show more Health Resources and Services Administration 9/03/2009
DUKE UNIVERSITY $59,966 Trans-NIH Recovery Act Research Support Radiation exposure from a nuclear accident or potential terrorist attack can cause death from acute injury or from late effects of radiation. Studies of the survivors of the atomic bomb at Hiroshima reveal that many radiation-induced deaths occurred years National Institutes of Health 5/10/2010
DUKE UNIVERSITY $59,661 Trans-NIH Recovery Act Research Support Mathematical abilities in adult humans exceed the numerical capacities of any non-human animal. Although neither rat nor monkey is likely to balance a checkbook or prove Pythagorous' theorem there is considerable evidence that non-human animals are capabl National Institutes of Health 7/30/2010
TRIANGLE J COUNCIL OF GOVERNMENTS $58,396 ARRA - Communities Putting Prevention to Work: Chronic Disease Self-Manage In collaboration with the Recovery Act-funded Communities putting Prevention to Work (CPPW) program, this funding will support the deployment of evidenced-based chronic disease self-management programs that empower older peopl... Show more
This spending item is part of a $1,006,573 allocation. See details
Administration on Aging 3/31/2010
RESEARCH TRIANGLE INSTITUTE $58,222 Trans-NIH Recovery Act Research Support RTI will support Columbia University and Boston University in a collaborative study of the exposure and biological impacts of passive tobacco smoke exposure on adults and potentiall children. This support will come in several forms including: a) building National Institutes of Health 9/02/2010
NORTH CAROLINA CENTRAL UNIVERSITY $58,198 ARRA - Scholarships for Disadvantaged Students The purpose of the SDS award is to provide scholarships for disadvantage students that need financial assistance to continue their education. Preference for this scholarship will be given to nursing students from whom the cost of attendance to the unive... Show more Health Resources and Services Administration 6/14/2010
DUKE UNIVERSITY $58,088 Trans-NIH Recovery Act Research Support The aims of the ENCODE (Encyclopedia of DNA Elements) and modENCODE (model organism ENCODE) projects are to apply high-throughput, cost-efficient approaches to generate a catalog of functional elements in the human, worm, and fly genomes, which will serve
This spending item is part of a $2,789,724 allocation. See details
National Institutes of Health 9/30/2009
DUKE UNIVERSITY $57,763 To establish a coordinated process structured to meet previously-identified scientific needs for quantitative imaging biomarkers. The long-term objective is to establish processes and profiles that will lead to acceptance by the imaging community, clinica
This spending item is part of a $2,412,566 allocation. See details
National Institutes of Health 9/30/2010
DUKE UNIVERSITY $57,411 Trans-NIH Recovery Act Research Support Transcriptional silencing via promoter methylation of genes critically important for cell growth and differentiation plays a key role in myeloid leukemogenesis. Many genes are frequently methylated in acute myeloid leukemia (AML) including p15, estrogen r
This spending item is part of a $660,000 allocation. See details
National Institutes of Health 5/14/2009
DUKE UNIVERSITY $55,412 Trans-NIH Recovery Act Research Support Research to be conducted under the ARRA mechanism will accelerate the scientific tempo of a trial designed to understand the efficacy, mechanisms, and cost-effectiveness of alternative resuscitation strategies for septic shock. Trial recruitment will be e
This spending item is part of a $2,314,994 allocation. See details
National Institutes of Health 9/30/2009
DUKE UNIVERSITY $55,000 Technical support and administrative/management services: Task Order 6, Antiviral and Immune Plasma Infrastructure Development
This spending item is part of a $12,962,657 allocation. See details
National Institutes of Health 9/28/2009
DUKE UNIVERSITY $54,000 Trans-NIH Recovery Act Research Support We are requesting funds in this administrative supplement to accelerate the pace of research proposed in our K08 award. We have been working to determine the importance of HCV Core domain 3 in the accumulation of intracellular lipid. We have addressed mos National Institutes of Health 8/24/2009
DUKE UNIVERSITY $54,000 Trans-NIH Recovery Act Research Support Uropathogenic Escherichia coli (UPEC) is by far the leading cause of urinary tract infection (UTI), producing 8 of the 10 million infections in the US per year. The most serious complications of UTI include pyelonephritis, sepsis, and meningitis. However, National Institutes of Health 12/07/2009
DUKE UNIVERSITY $51,344 Trans-NIH Recovery Act Research Support The objective of the proposed research is to develop an ultrasonic, radiation-force based imaging system capable of locally quantifying the shear modulus of soft tissues throughout a 2D Field of View (FOV), and to investigate its utility in the context of National Institutes of Health 8/13/2009
DUKE UNIVERSITY $51,050 Trans-NIH Recovery Act Research Support Many patients who survive the first few days of critical illness do so with multiple residual organ failures. These patients become dependent on mechanical ventilation and other organ support systems initiated in the ICU. In order to help clarify prognosi
This spending item is part of a $459,156 allocation. See details
National Institutes of Health 8/31/2009
DUKE UNIVERSITY $51,000 Trans-NIH Recovery Act Research Support The proposed work will establish national networking of scientists by providing a new software system (VIVO) and support for scientists using VIVO. Scientists using VIVO will be able to find other scientists and their work. Conversely, scientists using
This spending item is part of a $12,201,380 allocation. See details
National Institutes of Health 9/25/2009
DUKE UNIVERSITY $50,583 Trans-NIH Recovery Act Research Support CTRIP Ex-vivo perfusion and ventilation of lungs to assess transplant suitability This Stage 1 Grand Opportunity (GO) Research Infrastructure project will refine and perfect techniques for assessment of suitability of human lungs for lung transplant (LTX)
This spending item is part of a $1,466,880 allocation. See details
National Institutes of Health 9/28/2009
DUKE UNIVERSITY $50,304 The Cancer Human Biobank (caHUB) - This is a national, standardized , biospecimen resource for the collection of human tissues which are a critical resource for cancer research. Contracts will be established with medical research adn healthcare entities
This spending item is part of a $60,000,000 allocation. See details
National Institutes of Health 9/04/2009
DUKE UNIVERSITY $50,000 Trans-NIH Recovery Act Research Support Project Summary: Impact of Automated Reporting of Kidney Function in the Veterans Affairs Healthcare System Chronic kidney disease (CKD) is a readily treatable but under-recognized condition that is common in the general population. Although easily dete National Institutes of Health 9/18/2009
DUKE UNIVERSITY $49,999 Trans-NIH Recovery Act Research Support This program will prepare Amy M. Pastva, PT, PhD, CCS, for a career as an independent clinician-scientist in academic research medicine, specializing in the study of allergic lung disease. Dr. Pastva has been pursuing rigorous training in cell biology and National Institutes of Health 9/11/2009
DUKE UNIVERSITY $49,900 Trans-NIH Recovery Act Research Support The application for administrative supplement is to request funds to purchase an imaging system to accelerate the tempo of the research proposed in the parent grant R01 GM084337-01A2, Small Molecules that Regulate Proteasome Activity. The overall goal of National Institutes of Health 9/30/2009
DUKE UNIVERSITY $49,851 Trans-NIH Recovery Act Research Support The Cancer Center will provide two staff persons one experienced with the Cancer Centers IT infrastructure (emphasis in data management) and one experienced with Cancer Center's clinical trial operations. These staff will perform a consultative role for t National Institutes of Health 9/30/2009
DUKE UNIVERSITY $49,346 Trans-NIH Recovery Act Research Support Summary The Richardson lab tools for structure validation and correction are a powerful system for improving the accuracy of experimental 3D structures of protein and RNA, and are the critical components of the MolProbity web server. As assessors for the National Institutes of Health 9/24/2009
DUKE UNIVERSITY $49,200 Trans-NIH Recovery Act Research Support Enhancing capacity in human subject protections for Chinese research studies The goal of this proposal is to enhance the capacity of investigators in the People's Republic of China to meet both their national standards for protecting human research subjec
This spending item is part of a $54,200 allocation. See details
National Institutes of Health 9/25/2010
DUKE UNIVERSITY $48,060 Trans-NIH Recovery Act Research Support Lipid A (endotoxin) is a glucosamine-based saccharolipid that constitutes the outer monolayer of the outer membrane of Gram-negative bacteria; it is also the active component of lipopolysaccharide that causes life- threatening Gram-negative septic shock. National Institutes of Health 6/04/2009
DUKE UNIVERSITY $47,070 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Gene expression patterns determine cell identity and are therefore essential for proper development and prevention of inappropriate cell proliferation. Expression patterns are determined by transcriptional activation a National Institutes of Health 6/25/2010
DUKE UNIVERSITY $46,870 Trans-NIH Recovery Act Research Support We are requesting a Recovery Act Administrative Supplement in order to facilitate our research goals to (1) conduct apoptosis studies within the pre-clinical cell-based model we developed using lymphoblastoid cell lines (LCLs) to associate genetic variati
This spending item is part of a $60,870 allocation. See details
National Institutes of Health 9/30/2009
DUKE UNIVERSITY $46,841 Trans-NIH Recovery Act Research Support The goal of this research project is to test key organizational and functional aspects of centromeres. Centromeres are critical for chromosome segregation, as they are the site of kinetochore formation and mediate chromosome movements during mitosis and m National Institutes of Health 9/16/2009
DUKE UNIVERSITY $46,529 Trans-NIH Recovery Act Research Support Obesity prevention among Black women is a major public health priority. At present, nearly 54% of the adult Black female population (aged 20 and older) is obese. The group also suffers disproportionately from obesity-related health consequences (e.g. many National Institutes of Health 9/22/2009
DUKE UNIVERSITY $45,999 Trans-NIH Recovery Act Research Support This supplemental award supports the Accelerating Clinical Trials of Novel Oncologic Path Ways (ACTNOW) program for Protocol ANBL0931, which is a Phase III Study of Chimeric Antibody 14.18 in High-Risk Neuroblastoma. The primary objective of study ANBL09
This spending item is part of a $1,981,588 allocation. See details
National Institutes of Health 8/07/2009
RESEARCH TRIANGLE INSTITUTE $45,000 Trans-NIH Recovery Act Research Support Infrastructure for Community-Linked Research to Address Disparities in HIV/AIDS To respond to the domestic HIV epidemic in general and reduce health disparities in HIV prevalence specifically, this project will build sustainable infrastructure to enable h
This spending item is part of a $999,777 allocation. See details
National Institutes of Health 7/06/2010
DUKE UNIVERSITY $42,827 Trans-NIH Recovery Act Research Support Purpose: To test the hypothesis that coactivator posttranslational modifications control the in vivo systems biology of mammals.
This spending item is part of a $124,650 allocation. See details
National Institutes of Health 9/30/2010
BIOMERIEUX , INC. $41,584 ID BACTERIOLOGY ID & SENSITIVITY SYSTEM Indian Health Service 8/24/2009
DUKE UNIVERSITY $40,608 Trans-NIH Recovery Act Research Support Title: Evaluating an emergency department observation syncope protocol for older adults This application addresses the broad Challenge Area (05): Comparative Effectiveness Research, and specific Challenge Topic: G?05-AG-104. Planning grants and pilot st
This spending item is part of a $538,000 allocation. See details
National Institutes of Health 9/29/2009
DUKE UNIVERSITY $40,291 Trans-NIH Recovery Act Research Support This project will explore how historic changes in young women?s access to oral contraception affected the health of women and their children. During the 1960s and 1970s, most states changed the age at which young unmarried women could obtain a prescriptio
This spending item is part of a $165,461 allocation. See details
National Institutes of Health 5/29/2009
DUKE UNIVERSITY $40,000 Trans-NIH Recovery Act Research Support Red blood cell transfusions are extremely common medical interventions with more than 11 million red blood cell units transfused in the United States and 75 million worldwide. Yet, it remains unclear when patients should receive red blood cell transfusion
This spending item is part of a $2,605,144 allocation. See details
National Institutes of Health 9/30/2009
DUKE UNIVERSITY $39,000 Trans-NIH Recovery Act Research Support Devastating cardiac developmental malformations are linked to environmental toxins, but the biological mechanisms are not known. Our objective is to create heart specific transgenic zebrafish fluorescent reporter strains that will signal when vertebrate National Institutes of Health 9/02/2009
DUKE UNIVERSITY $37,871 Trans-NIH Recovery Act Research Support The broad long-range goals of this project are to understand how two major classes of chemotherapeutic agents cause DNA damage and how cells deal with DNA-protein crosslinks which are induced by these agents. The repair of DNA-protein crosslinks is very p National Institutes of Health 1/20/2010
DUKE UNIVERSITY $36,809 Trans-NIH Recovery Act Research Support The overarching goal of our NIH-funded project 5R37DK46492-17, now in its 17th year, has been to gain fundamental insights into the biochemical and molecular mechanisms involved in acute regulation of insulin secretion by glucose and other metabolic fuels National Institutes of Health 12/03/2009
DUKE UNIVERSITY $35,543 Trans-NIH Recovery Act Research Support The American College of Surgeons Oncology Group (ACOSOG) is dedicated to improving the care of the surgical oncology patient through an innovative clinical research program addressing three specific aims: 1. To test novel therapies that may increase respo
This spending item is part of a $106,834 allocation. See details
National Institutes of Health 9/21/2009
DUKE UNIVERSITY $33,423 To establish a coordinated process structured to meet previously-identified scientific needs for quantitative imaging biomarkers. The long-term objective is to establish processes and profiles that will lead to acceptance by the imaging community, clinica
This spending item is part of a $2,412,566 allocation. See details
National Institutes of Health 9/30/2010
HAMNER INSTITUTES, THE $32,657 Trans-NIH Recovery Act Research Support 1. Instrument development: We will design and implement new coherence imaging instrumentation to enable examination of colorectal tissues for ex vivo studies. For the a/LCI surveillance studies, we will develop new fiber optic probe designs suitable for
This spending item is part of a $633,697 allocation. See details
National Institutes of Health 5/21/2009
DUKE UNIVERSITY $32,305 Trans-NIH Recovery Act Research Support Decision-Making For Infants with Complex Life-Threatening Conditions Abstract Infants with life-threatening conditions who earlier would have died in the first months of life are now receiving highly complex and sometimes experimental treatments designed
This spending item is part of a $97,305 allocation. See details
National Institutes of Health 2/23/2010
DUKE UNIVERSITY $31,318 The Cancer Human Biobank (caHUB) - This is a national, standardized , biospecimen resource for the collection of human tissues which are a critical resource for cancer research. Contracts will be established with medical research adn healthcare entities
This spending item is part of a $60,000,000 allocation. See details
National Institutes of Health 9/04/2009
DUKE UNIVERSITY $28,960 Trans-NIH Recovery Act Research Support The overarching goal of our NIH-funded program project PO1DK58398-9, now in its ninth year, has been to develop new therapies for type 2 diabetes by melding of novel insights into b-cell biology with unique metabolic analysis, imaging, and molecular manip National Institutes of Health 12/09/2009
DUKE UNIVERSITY $27,453 Trans-NIH Recovery Act Research Support The objective of this proposal is to determine how changes in intracellular Ca2+, the ultimate signal of electrical activity, regulate cardiac membrane excitability. Dysregulation of Ca2+, however, contributes to cardiac arrhythmias. Given the potential p National Institutes of Health 6/04/2009
DUKE UNIVERSITY $27,106 Trans-NIH Recovery Act Research Support To date, one must conclude that the pace of progress in disease control and preservation of functional integrity and quality of life for pediatric brain tumors remains below that of most other major types of childhood cancers. Recent advances in cellular
This spending item is part of a $482,434 allocation. See details
National Institutes of Health 8/19/2009
DUKE UNIVERSITY $26,401 Trans-NIH Recovery Act Research Support Although several clinical trials have identified interventions that reduce adverse outcomes such as falls in nursing home (NH) residents, attempts to translate those interventions into practice using widely accepted quality improvement (QI) techniques hav National Institutes of Health 5/13/2010
DUKE UNIVERSITY $25,969 Trans-NIH Recovery Act Research Support Glioblastoma Multiforme (GBM) is the most aggressive form of glial neoplasia and accounts for approximately 60% of all malignant primary brain tumors. Although current standard therapy targeting GBM incorporates surgery, radiation, and chemotherapy, patie National Institutes of Health 6/01/2009
DUKE UNIVERSITY $25,506 Trans-NIH Recovery Act Research Support To date, one must conclude that the pace of progress in disease control and preservation of functional integrity and quality of life for pediatric brain tumors remains below that of most other major types of childhood cancers. Recent advances in cellular
This spending item is part of a $381,202 allocation. See details
National Institutes of Health 8/20/2009
DUKE UNIVERSITY $24,068 Trans-NIH Recovery Act Research Support This application entitled, 'Discovering Pathways of Functional Decline: A GWAS Approach' addresses the challenge area (08): Genomics and the specific challenge topic, 08-AG-101: Genetic factors affecting rates of change in disease risk factors with age. T
This spending item is part of a $814,020 allocation. See details
National Institutes of Health 9/24/2009
DUKE UNIVERSITY $23,213 Trans-NIH Recovery Act Research Support Angiogenesis, the growth of new capillaries from pre-existing blood vessels, is tightly regulated by a number of vascular growth factors and their cognate receptor tyrosine kinases expressed on endothelial cells; principal among these factors is vascular National Institutes of Health 7/15/2009
DUKE UNIVERSITY $22,450 Trans-NIH Recovery Act Research Support The funds will be used to develop, open and analyze three H1N1 studies in HIV-infected populations. The first study will determine the safety and immunogenicity of an H1N1 vaccine in HIV-infected pregnant women. The second study will determine safety an
This spending item is part of a $1,701,287 allocation. See details
National Institutes of Health 11/25/2009
DUKE UNIVERSITY $22,450 Trans-NIH Recovery Act Research Support The funds will be used to develop, open and analyze three H1N1 studies in HIV-infected populations. The first study will determine the safety and immunogenicity of an H1N1 vaccine in HIV-infected pregnant women. The second study will determine safety an
This spending item is part of a $1,701,287 allocation. See details
National Institutes of Health 11/25/2009
DUKE UNIVERSITY $19,344 Trans-NIH Recovery Act Research Support The fundamental scientific problem we propose to address is to determine the basic neural and molecular requirements for vocal learning, which is the behavioral substrate for spoken language, one of the essential behaviors that make us human. Spoken lang National Institutes of Health 8/10/2009
DUKE UNIVERSITY $19,250 Trans-NIH Recovery Act Research Support I am requesting an administrative supplement to hire an Undergraduate Student for an NIH-funded application (HL081395) under the auspices of the American Recovery and Reinvestment Act of 2009 (NOT-OD-060). The goals of this administrative supplement are t National Institutes of Health 6/01/2009
DUKE UNIVERSITY $17,622 Trans-NIH Recovery Act Research Support Drugs of abuse induce persistent adaptations in neuronal function that are driven in part by the drug-induced expression of new gene products which modulate synaptic function and neuronal excitability. My laboratory has been studying the role of epigeneti National Institutes of Health 6/19/2009
DUKE UNIVERSITY $14,251 Trans-NIH Recovery Act Research Support The American College of Surgeons Oncology Group (ACOSOG) is dedicated to improving the care of the surgical oncology patient through an innovative clinical research program addressing three specific aims: 1. To test novel therapies that may increase respo
This spending item is part of a $259,351 allocation. See details
National Institutes of Health 6/18/2010
DUKE UNIVERSITY $14,040 Trans-NIH Recovery Act Research Support We propose to study the political economy of tobacco in low- and middle-income countries in Southeast Asia. Through a regional research and capacity building program, we seek to enable those in the region to respond more effectively to the challenge of to National Institutes of Health 6/01/2009
DUKE UNIVERSITY $13,075 Trans-NIH Recovery Act Research Support The funds will be used to develop, open and analyze three H1N1 studies in HIV-infected populations. The first study will determine the safety and immunogenicity of an H1N1 vaccine in HIV-infected pregnant women. The second study will determine safety an
This spending item is part of a $1,701,287 allocation. See details
National Institutes of Health 11/25/2009
DUKE UNIVERSITY $12,808 Trans-NIH Recovery Act Research Support We have previously identified a point mutation in thes Transient Receptor Potential Cation Channel 6 (TRPC6) gene causing an autosomal dominant form of familial focal and segmental glomerulosclerosis (FSGS). This P112Q substitution causes a marked alterat National Institutes of Health 7/20/2009
Community Health Coalition $12,709 Trans-NIH Recovery Act Research Support ARRA - Community Participation Research of Breastfeeding Disparities in African. Project Description: The resources provided allowed for several important project enhancements: 1. The parent grant provided us with sufficient resources to survey individual
This spending item is part of a $39,832 allocation. See details
National Institutes of Health 9/23/2009
Community Health Coalition $12,709 Trans-NIH Recovery Act Research Support Esophageal Cytoprotection: Agents and Mechanisms (ARRA) The long term goal of this proposal is to understand the pathogenesis of gastroesophageal reflux disease (GERD), and by this means, to open up new avenues for its diagnosis and treatment. The goal is
This spending item is part of a $97,853 allocation. See details
National Institutes of Health 9/23/2009
DUKE UNIVERSITY $11,761 Trans-NIH Recovery Act Research Support Primary Hyperoxaluria type I (PH1) is a severe kidney stone disease caused by deficiency of the protein alanine: glyoxylate aminotransferase (AGT). In many patients, deficiency of AGT results from missense mutations that decrease the stability of this enz National Institutes of Health 7/13/2009
DUKE UNIVERSITY $11,156 Trans-NIH Recovery Act Research Support The main goal of the summer student supplement is to provide a undergraduate student an opportunity to participate in our preclinical medication treatment project (5R01-DA012768, Cocaine Withdrawal: A Window of Treatment Opportunity). This project seeks National Institutes of Health 6/01/2009
DUKE UNIVERSITY $10,920 Trans-NIH Recovery Act Research Support Sensory representations within the thalamocortical loop (TCL) are dynamically modulated constructs that emerge from the asynchronous convergence of multiple ascending and descending afferents. Also, tactile neuronal responses in S1 layers differ profoundl National Institutes of Health 6/01/2009
DUKE UNIVERSITY $10,383 Trans-NIH Recovery Act Research Support In this supplement, we propose to further characterize the programs in the ovary which antagonize the male pathway and ask the question, what role do XX germ cells play in blocking testis cord formation. Several lines of evidence suggest that XX germ ce National Institutes of Health 7/13/2009
DUKE UNIVERSITY $10,296 Trans-NIH Recovery Act Research Support While there are a number of surgical alternatives to autologous large diameter vascular grafts, i.e. allografts, xenografts, and synthetic vascular graft substitutes, there are no clinically acceptable alternatives to healthy autologous small diameter (<6 National Institutes of Health 6/04/2009
DUKE UNIVERSITY $7,539 Trans-NIH Recovery Act Research Support Ambient ozone is associated with increased respiratory illness, hospitalizations, and cardiovascular mortality. Because the lung is recurrently exposed to low level ozone, understanding how ozone modifies immune mechanisms is of considerable importance to National Institutes of Health 5/15/2009
DUKE UNIVERSITY $6,418 Trans-NIH Recovery Act Research Support P-ARRESTINS AND GRKs IN CARDIOVASCULAR FUNCTION. G protein coupled receptors (GPCRs) such as those for catecholamines and angiotensin II regulate cardiovascular functions including vasoconstriction and vasodilation; vascular smooth muscle cell (VSM) mitog National Institutes of Health 7/13/2009
DUKE UNIVERSITY $5,585 Trans-NIH Recovery Act Research Support Cryptococcus neoformans is a fungal pathogen that causes meningitis in both immunocompromised and immunocempetent patients. The ability to grow at human physiological temperature is an essential virulence factor of C. neoformans, which is orchestrated by National Institutes of Health 7/14/2009
DUKE UNIVERSITY $2,196 Trans-NIH Recovery Act Research Support The funds will be used to develop, open and analyze three H1N1 studies in HIV-infected populations. The first study will determine the safety and immunogenicity of an H1N1 vaccine in HIV-infected pregnant women. The second study will determine safety an
This spending item is part of a $1,701,287 allocation. See details
National Institutes of Health 11/25/2009
DUKE UNIVERSITY $2,000 Trans-NIH Recovery Act Research Support This is a translational research proposal to elucidate the mechanisms underlying apparent differences in end-organ iron deposition between patients with sickle cell anemia (SCD), thalassemia (TM) and Diamond Blackfan Anemia (DBA). Increasing numbers of
This spending item is part of a $645,010 allocation. See details
National Institutes of Health 9/10/2009
DUKE UNIVERSITY $2,000 Trans-NIH Recovery Act Research Support This is a translational research proposal to elucidate the mechanisms underlying apparent differences in end-organ iron deposition between patients with sickle cell anemia (SCD), thalassemia (TM) and Diamond Blackfan Anemia (DBA). Increasing numbers of
This spending item is part of a $645,010 allocation. See details
National Institutes of Health 9/10/2009
DUKE UNIVERSITY $0 Trans-NIH Recovery Act Research Support Advancing Diffusion Tensor Imaging and Analyses for Basic Alcohol Research - ARR. The purpose of this project is to rapidly advance DTI technology and its application to discovery and documentation of alcohol?s deleterious effects on the pre-and postnatal
This spending item is part of a $903,834 allocation. See details
National Institutes of Health 9/22/2009