Recovery Tracker

How Much Stimulus Funding is Going to Your County?

Cuyahoga County, Ohio, funds by Health and Human Services, Department of

Listing $120,775,424.92 in stimulus funds from Health and Human Services, Department of for Cuyahoga

Note: For some programs where states do not report where money will be distributed across the state, we do not have the allocation for individual counties. Those programs include: Medicaid, unemployment benefits and food stamps. Those amounts are included in the totals for where the state agency receiving that money is located.

Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.

Recipient Amount Description Federal Dept./Agency Date
Cuyahoga County $13,136,052 ARRA Child Care and Development Block Grant $59,245,395 of the ARRA Discretionary funds will be spent during State Fiscal Year 2010 to stabilize the subsidized child care budget thus permitting the continuation of service to existing families. $5,620,429 of the ARRA Targeted Funds for Quality Exp
This spending item is part of a $68,140,840 allocation. See details
Administration for Children and Families 4/09/2009
COUNCIL FOR ECONOMIC OPPORTUNITIES IN GREATER CLEVELAND $5,289,457 ARRA - Community Services Block Grant This fund may be used for reduction of poverty, the revitalization of low-income communities, and the empowerment of low income families and individuals in rural and urban areas to become fully self-sufficient. The Award amount has reduced from $38,976,10
This spending item is part of a $38,857,606 allocation. See details
Administration for Children and Families 4/10/2009
CUYAHOGA COMMUNITY COLLEGE $3,170,494 ARRA - Health Information Technology Professionals in Health Care The Midwest Community College Health Information Technology Consortium provides training in six work force roles to support electronic health records implementation across 10 Midwest states through campus-based training, distance learn... Show more
This spending item is part of a $14,897,896 allocation. See details
Health and Human Services, Department of 4/02/2010
WEST SIDE ECUMENICAL MINISTRY $3,078,874 ARRA - Early Head Start EHS 2009 ARRA Expansion. This award provided funding to serve 156 early Head Start Children. The Early Head Start program provides family-centered services for low-income families with young children (pre-birth to 3) to promote healthy development of ch Administration for Children and Families 11/30/2009
CASE WESTERN RESERVE UNIVERSITY $2,435,464 The Systolic Blood Pressure Intervention Trial (SPRINT). SRINT is a 2-arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure (SBP) to a lower goal than currently recommended will National Institutes of Health 9/23/2010
CASE WESTERN RESERVE UNIVERSITY $2,190,865 Trans-NIH Recovery Act Research Support Project Summary/Abstract This application addresses Grand Opportunity: Phase 2 Clinical Trials Program of Novel Therapies for HLB Diseases. Obstructive sleep apnea (OSA) afflicts > 5% of adults and is associated with a 2 to 4-fold increased risk of cardio National Institutes of Health 9/25/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $2,039,261 National Center for Research Resources, Recovery Act Construction Support In the last decade the Cleveland Clinic Taussig Cancer Institute (TCI) has demonstrated tremendous growth in terms of cancer care, clinical trials and translational cancer research. This expansion was initially enabled by a mov... Show more National Institutes of Health 3/25/2010
CASE WESTERN RESERVE UNIVERSITY $1,881,285 Trans-NIH Recovery Act Research Support Genome-wide association studies (GWAS) provide a new and powerful approach to investigate the effect of inherited genetic variation on risks of complex diseases. With recent advances in genotyping technology, genome-wide association studies are now becomi National Institutes of Health 7/22/2009
NORTHEAST OHIO NEIGHBORHOOD HEALTH SERVICES, INC. $1,694,065 ARRA Health Center Integrated Services Development Initiative[g1] NEON's Capital Improvement Project - to improve access to primary care for Greater Cleveland residents. Health Resources and Services Administration 6/25/2009
NORTHEAST OHIO NEIGHBORHOOD HEALTH SERVICES, INC. $1,694,065 ARRA Health Center Integrated Services Development Initiative[g1] NEON's Capital Improvement Project - to improve access to primary care for Greater Cleveland residents. Health Resources and Services Administration 6/25/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $1,627,009 We have been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically to establish a Tissue Source Site (TSS) Network capable of delivering clinically annotated biospecimens through either or both retr National Institutes of Health 9/27/2010
CASE WESTERN RESERVE UNIVERSITY $1,570,000 Trans-NIH Recovery Act Research Support This award is for the recruitment of junior faculty who will be involved in melanoma research and will serve to expand an initiative in melanoma disase focused basic and translational research at Case Comprehensive Cancer Center. Funds will support their National Institutes of Health 9/29/2009
CASE WESTERN RESERVE UNIVERSITY $1,552,953 Trans-NIH Recovery Act Research Support In addition to the increase in obesity in adult and children, there has been a significant increase in birth weights over the last 2 decades. Based on our preliminary data, maternal pregravid obesity is the strongest risk factor for neonatal as well as a National Institutes of Health 7/13/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $1,508,834 Trans-NIH Recovery Act Research Support any neurological disorders, including hydrocephalus, result in brain injury and dysfunction in part through decreased cerebral blood flow (CBF). Evidence from clinical and experimental studies indicates that reduced CBF may be, in part, caused by impaired National Institutes of Health 8/20/2009
CASE WESTERN RESERVE UNIVERSITY $1,461,630 Trans-NIH Recovery Act Research Support This supplement was awarded to provide research support for a newly recruited physician scientist. This new faculty member has the primary goal of establishing a translational research program that will lead the way in developing new therapeutic strate National Institutes of Health 9/24/2009
CASE WESTERN RESERVE UNIVERSITY $1,366,682 Trans-NIH Recovery Act Research Support Neural regulation of immature airways serves to balance airway smooth muscle [ASM] contractile and relaxant pathways. This balance is readily disrupted in early postnatal life and may predispose to later airway hyperreactivity. In the two previous cycles National Institutes of Health 7/16/2009
CASE WESTERN RESERVE UNIVERSITY $1,334,973 Trans-NIH Recovery Act Research Support Chronic illness and health disparities are prevalent in the United States. More than 61 million Americans have heart disease, 20 million have diabetes, 50 million have hypertension, and 7.4 million have kidney disease. Those from racial and ethnic minorit National Institutes of Health 9/30/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $1,223,244 Trans-NIH Recovery Act Research Support he overall goal of this project is to determine the role of oxidative stress with associated inflammation and abnormalities in nitric oxide synthase (NOS) in the pathogenesis of clinical cardiovascular disease (CVD), carotid IMT, cardiac MRI and microvasc
This spending item is part of a $1,370,948 allocation. See details
National Institutes of Health 7/20/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $1,212,874 Trans-NIH Recovery Act Research Support Refinement and enhancement of a web-based risk calculator deployment system .The quality of medical decision making suffers because risk predictions are not tailored to the individual patient. Further, available risk models and tools are not widely used b National Institutes of Health 8/24/2010
CASE WESTERN RESERVE UNIVERSITY $1,158,610 Trans-NIH Recovery Act Research Support This application proposes establishment of an interdisciplinary biomedical core focused on quality of life research for seriously ill people, including those who are at the end of life. The proposed biomedical core center, Building End-of-Life Science thr National Institutes of Health 9/30/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $1,142,609 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Nonalcoholic fatty liver disease (NAFLD) in humans has become an increasing public health problem paralleling the increase in obesity, type II diabetes, and changing dietary and activity patterns. The spectrum of NAFLD National Institutes of Health 9/28/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $999,998 Trans-NIH Recovery Act Research Support RNA cleavage is a fundamental and ancient host response for controlling viral infections in both plants and animals. In higher vertebrates, including humans, RNA cleavage as a means of controlling viruses is mediated by the type I interferons (IFN) throug National Institutes of Health 9/25/2009
CASE WESTERN RESERVE UNIVERSITY $999,998 Trans-NIH Recovery Act Research Support This proposal, entitled Vascularization of Polymeric Tissue Beds, seeks to address the broad Challenge Area of (11) Regenerative Medicine, and the specific Challenge Topic of vascular networks in engineered tissues: 11-EB-101. The major impediment to prog National Institutes of Health 9/22/2009
CASE WESTERN RESERVE UNIVERSITY $997,175 Trans-NIH Recovery Act Research Support The major coronary arteries form in stereotyped locations. Abnormalities in location such as in Anomalous Left Coronary Artery from the Pulmonary Artery (ALCAPA) have serious clinical consequences including sudden death. The overall aim of this study is t National Institutes of Health 8/14/2009
CASE WESTERN RESERVE UNIVERSITY $982,989 Trans-NIH Recovery Act Research Support The grant entitled Therm Electron LTQ Orbitrap XL will enhance mass spectrometry capability and research throughput of the Center for Proteomics and Bioinformatics (CPB) at Case Western Reserve University. The user group supported by this Center is growin National Institutes of Health 7/08/2010
CASE WESTERN RESERVE UNIVERSITY $981,254 Trans-NIH Recovery Act Research Support Clinical, pathologic, and experimental studies support an important role for the macrophage in a broad spectrum of acute (e.g. pathogen infection, sepsis) and chronic inflammatory conditions (e.g. insulin resistance, atherosclerosis and tumorigenesis). Re National Institutes of Health 8/31/2009
CASE WESTERN RESERVE UNIVERSITY $978,776 Trans-NIH Recovery Act Research Support The supplement to the Center for Translational Science Award (UL1-RR024989) based at Case Western Reserve University, and involving University Hospitals, Cleveland Clinic, and Metro Health Center, will Advance Translational (T1& T2) Research through the d National Institutes of Health 9/29/2009
CASE WESTERN RESERVE UNIVERSITY $978,256 Trans-NIH Recovery Act Research Support Community Voices on Health Disparities and Translational Genomics Research Challenge Area and Specific Challenge Topic: The Challenge Area this research addresses is 02: Bioethics and the Specific Challenge Topic is 02- OD9OSP-102* Ethical Issues in Healt National Institutes of Health 9/24/2009
CASE WESTERN RESERVE UNIVERSITY $972,594 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (11): Regenerative Medicine and specific Challenge Topic, 11-HL-101: Develop cell-based therapies for cardiovascular, lung, and blood diseases. Sudden cardiac death (SCD) due to myocardial infarction (MI) is National Institutes of Health 9/23/2009
CASE WESTERN RESERVE UNIVERSITY $942,573 Trans-NIH Recovery Act Research Support It is estimated that 5.3 million Americans have Alzheimer's disease (AD), and that the number and proportion of Americans affected by AD is expected to grow rapidly in the next several decades. The striking increase in numbers of individuals with AD has b National Institutes of Health 9/28/2010
CASE WESTERN RESERVE UNIVERSITY $922,558 Trans-NIH Recovery Act Research Support Implementation of a web-based version of S.A.G.E. (Statisitcal Analysis for Genetic Epidemiology), preparation of a version of the S.A.G.E. short course suitable for clinical scientists to be given locally, development of a program to detect gene-gene int National Institutes of Health 9/14/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $873,669 Trans-NIH Recovery Act Research Support This ARRA Challenge Grant application addresses Broad Challenge Area (05) - Comparative Effectiveness Research and Specific Challenge Topic 05-AG-105 - Comparative Intervention Trials for Diseases and Syndromes of Aging Including Neurodegenerative Disease
This spending item is part of a $968,509 allocation. See details
National Institutes of Health 9/24/2009
CASE WESTERN RESERVE UNIVERSITY $862,894 Trans-NIH Recovery Act Research Support These experiments are deisgned to utilize the rhesus vaginal challenge model to explore the plausibility of two distinct hypotheses regarding the determinants of protection from HIV infection among persons exsposed to HIV infection but who have remained u
This spending item is part of a $963,378 allocation. See details
National Institutes of Health 5/10/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $834,860 Trans-NIH Recovery Act Research Support his application addresses broad Challenge Area (02): Bioethics and specific Challenge Topic 02- OD(OSP)-101: Unique Ethical Issues Posed by Emerging Technologies. The current study examines the ethical challenges inherent in participants' considerations o National Institutes of Health 9/25/2009
CASE WESTERN RESERVE UNIVERSITY $834,093 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (06) Enabling Technologies and Specific Challenge Topic, 06-NS-104: Developing and validating assistive neuro-technologies. Respiratory complications account for significant morbidity and mortality in patien National Institutes of Health 9/25/2009
CASE WESTERN RESERVE UNIVERSITY $822,680 Trans-NIH Recovery Act Research Support An understanding of the morphogenesis and operation of hair cells requires identification of the genes expressed in these cells and of the functions of the cognate proteins. As an initial step towards this goal, we have used DNA-microarray technology to i National Institutes of Health 6/05/2009
CASE WESTERN RESERVE UNIVERSITY $809,181 Trans-NIH Recovery Act Research Support In response to changing afferent input, neural pathways may undergo both short term (minutes) and long term (days, weeks) adjustments within the pathway in order to maintain physiological output within an appropriate range. The underlying cellular mechani National Institutes of Health 7/16/2009
CASE WESTERN RESERVE UNIVERSITY $805,318 Trans-NIH Recovery Act Research Support Metaplastic transformation of the esophagus, termed Barrett's esophagus (BE) is a premalignant condition with a 1 per 200 patient-years risk of malignant progression to esophageal adenocarcinoma. The incidence of esophageal adenocarcinoma has increased dr National Institutes of Health 9/30/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $790,008 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant: Chronic inflammation is a major contributor to the onset and progression of atherosclerosis and other vascular disorders. Studies of inflammation have focused primarily on the initiating processes and less attention has National Institutes of Health 9/21/2009
CASE WESTERN RESERVE UNIVERSITY $788,415 Trans-NIH Recovery Act Research Support Ion channels use the energy stored in ionic gradients to initiate rapid signaling events essential for the function of virtually every cell in the body. Although channel activation can occur in response to a variety of different stimuli, once open all cha National Institutes of Health 8/31/2009
CASE WESTERN RESERVE UNIVERSITY $785,000 Trans-NIH Recovery Act Research Support The objective of this proposal is to recruit two tenure track Assistant Professor RNA biologists, one who specializes in bioinformatics and one who specializes in genomic approaches to the study of non-coding RNAs, to join and complement the faculty of th National Institutes of Health 9/30/2009
CASE WESTERN RESERVE UNIVERSITY $785,000 Trans-NIH Recovery Act Research Support The aim of this application is to investigate the role of these caspases in villous cytotrophoblast differentiation. The ultimate goal of this investigation is to identify the critical components controlling the mechanism of villous cytotrophoblast diffe National Institutes of Health 7/28/2009
CASE WESTERN RESERVE UNIVERSITY $762,302 Trans-NIH Recovery Act Research Support The Department of Biomedical Engineering (BME) at Case Western Reserve University (CWRU) views translational research, nanotechnology, and development of biomedical and radiologic imaging as part of its vision and mission. Via the recruitment of a tenure- National Institutes of Health 9/22/2009
CASE WESTERN RESERVE UNIVERSITY $754,587 Trans-NIH Recovery Act Research Support Post-stroke shoulder pain is a major rehabilitation problem affecting up to 60% of moderate to severely impaired stroke survivors. Surface electrical stimulation (ES) of muscles surrounding the hemiparetic shoulder is the only intervention with evidence o National Institutes of Health 9/17/2009
CASE WESTERN RESERVE UNIVERSITY $742,017 ARRA - Nurse Faculty Loan Program The Nurse Faculty Loan Program provides funds to eligible schools of nursing that offer advanced education nursing programs to prepare graduates to serve as faculty in a school of nursing. The schools use the funds to establish distinct NFLP fund account Health Resources and Services Administration 6/14/2010
CASE WESTERN RESERVE UNIVERSITY $724,137 Trans-NIH Recovery Act Research Support This application addresses Grand Opportunity: Phase 2 Clinical Trials Program of Novel Therapies for HLB Diseases. Obstructive sleep apnea (OSA) afflicts > 5% of adults and is associated with a 2 to 4-fold increased risk of cardiovascular disease (CVD). D
This spending item is part of a $3,126,139 allocation. See details
National Institutes of Health 9/07/2010
NORTHEAST OHIO NEIGHBORHOOD HEALTH SERVICES, INC. $715,045 ARRA Health Center Integrated Services Development Initiative[g1] NEON Increase Demand in Services Project - to increase access to primary care for residents in the Greater Cleveland area Health Resources and Services Administration 3/27/2009
CASE WESTERN RESERVE UNIVERSITY $706,500 Trans-NIH Recovery Act Research Support Vitamin D receptor coactivators in bone. 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the bioactive hormone of the vitamin D endocrine system. It functions via the vitamin D receptor (VDR) to impact bone by increasing intestinal calcium absorption and by di National Institutes of Health 7/17/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $706,500 Trans-NIH Recovery Act Research Support Pre-mRNA alternative splicing is a common means by which cells generate multiple, functionally distinct isoforms from a single gene. Developmentally regulated splicing has been described individually for many genes, yet little is known about how programs National Institutes of Health 6/01/2009
CASE WESTERN RESERVE UNIVERSITY $705,751 Trans-NIH Recovery Act Research Support In that mucosal T lymphocytes are enmeshed in the complex and highly organized network of proteins, glycoproteins, and proteoglycans known as the extracellular matrix (ECM), we propose that the chronicity, exacerbation, and recurrence of IBD are multifact National Institutes of Health 9/03/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $669,339 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): This proposal demonstrates a novel healthcare delivery system that has the potential to significantly advance stroke rehabilitation monitoring and therapy. The broad, long-term objective is to provide accessible, affor
This spending item is part of a $2,745,978 allocation. See details
National Institutes of Health 5/24/2010
COUNCIL FOR ECONOMIC OPPORTUNITIES IN GREATER CLEVELAND $653,303 ARRA - Head Start This award provides for ARRA Cost of Living Adjustment(COLA) and Quality Improvement Funding consistent with the provisions of Section 640 (a) (5) of the Head Start Act for the Head Start and Early Head Start program. Head Start promotes the school read
This spending item is part of a $2,452,629 allocation. See details
Administration for Children and Families 7/14/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $651,550 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Breast cancer is responsible for the second overall cause of cancer-related deaths among women. Despite this profound health risk, Immunotherapy for breast cancer has not been adequately developed as an integral part o National Institutes of Health 5/21/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $651,550 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Uveal melanoma is a rare malignancy of the eye. Survival rates are poor. Metastatic disease occurs frequently and invariably results in death. At present there is insufficient evidence to support the use of any systemi National Institutes of Health 8/13/2009
CASE WESTERN RESERVE UNIVERSITY $648,384 Trans-NIH Recovery Act Research Support The long-range goal of this research is to understand the mechanism of glucocorticosteroid action in lymphoid malignancy, providing information to guide development of novel therapeutic approaches. Glucocorticoids including prednisone and dexamethasone ar National Institutes of Health 6/19/2009
CASE WESTERN RESERVE UNIVERSITY $647,060 Trans-NIH Recovery Act Research Support This Administrative Supplement application is in response to NOT-RR-10-001, NIH Announces the Availability of Recovery Act Funds for Administrative Supplements to Support Core Consolidation. The project is entitled G?Core Consolidation: Behavioral Measure National Institutes of Health 9/29/2010
NEIGHBORHOOD HEALTH CARE INC $638,115 ARRA Health Center Integrated Services Development Initiative[g1] The award has three project titles: The first project is Renovation of Ridge Road Facility with total project costs of $435,287.00. This project will upgrade, build and improve the Ridge Road facility. Items included in the renovation ... Show more Health Resources and Services Administration 6/25/2009
CASE WESTERN RESERVE UNIVERSITY $601,133 We have been awarded the 'RECOVERY-Tissue Source Site (TSS) Networks in Support of The Cancer Genome Atlas (TCGA) Program' contract to provide gliomas to the NCI. Specifically to establish a TSS network capable of delivering clinically annotated biospeci
This spending item is part of a $715,438 allocation. See details
National Institutes of Health 9/24/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $578,748 Trans-NIH Recovery Act Research Support Transplantation is the ideal therapy for end stage heart and end stage kidney failure, but allograft survival and function remain suboptimal. This CTOT renewal application will build upon the findings resulting from the previous 4 years of studying biomar
This spending item is part of a $9,955,156 allocation. See details
National Institutes of Health 9/13/2010
THE CLEVELAND CLINIC FOUNDATION $572,560 We have been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically to establish a Tissue Source Site (TSS) Network capable of delivering clinically annotated biospecimens through either or both retr
This spending item is part of a $1,627,009 allocation. See details
National Institutes of Health 9/27/2010
CASE WESTERN RESERVE UNIVERSITY $559,500 Trans-NIH Recovery Act Research Support Bacterial polysaccharides are traditionally viewed as molecules that do not form stable secondary structure and are unable to elicit a protective T lymphocyte-driven immune response. We have recently discovered that one class of polysaccharide not only ac National Institutes of Health 7/17/2009
CASE WESTERN RESERVE UNIVERSITY $554,660 Trans-NIH Recovery Act Research Support The Cornea Donor Study (CDS) and its ancillary study, the Specular Microscopy Ancillary Study (SMAS), are examining the effect of donor age and the predictive value of endothelial cell density (ECD) on cornea graft survival. The study enrolled 1,101 subj
This spending item is part of a $693,507 allocation. See details
National Institutes of Health 9/30/2009
CASE WESTERN RESERVE UNIVERSITY $551,988 Trans-NIH Recovery Act Research Support Mutations in a series of ppGalNAc glycosyltransferases (protein glycosylating enzymes) have recently been found in patients with colon cancer. In this work we will study the enzymatic and biological properties of a series of mutant and wild type ppGalNA National Institutes of Health 4/28/2009
CARE ALLIANCE $546,765 ARRA Health Center Integrated Services Development Initiative[g1] Care Alliance's Capital Improvement Program will enable us to better serve its patients by increasing its efficiency as a technologically enhanced health center and by securing the equipment needed to provide the highest quality of car... Show more Health Resources and Services Administration 6/29/2009
COUNCIL FOR ECONOMIC OPPORTUNITIES IN GREATER CLEVELAND $544,859 ARRA - Head Start This award provides for ARRA Cost of Living Adjustment(COLA) and Quality Improvement Funding consistent with the provisions of Section 640 (a) (5) of the Head Start Act for the Head Start and Early Head Start program. Head Start promotes the school read
This spending item is part of a $2,452,629 allocation. See details
Administration for Children and Families 7/14/2009
Western Reserve Area Agency On Aging $518,702 Aging Congregate Nutrition Services for States The Adminstration of Aging has made additional funding available for congregate meals. These funds support community programs that provide nutritious meals to individuals age 60 andolder at congregate settings (e.g., senior centers, churches).
This spending item is part of a $2,502,601 allocation. See details
Administration on Aging 3/18/2009
CASE WESTERN RESERVE UNIVERSITY $503,530 Trans-NIH Recovery Act Research Support Inflammatory bowel disease (IBD) affects approximately 1.4 million individuals in the US and several million worldwide. One of the major discoveries in the last 20 years in IBD research has been the key role cytokines play in intestinal inflammation and t National Institutes of Health 8/16/2010
CASE WESTERN RESERVE UNIVERSITY $500,000 Trans-NIH Recovery Act Research Support Faculty at Case Western Reserve University and its Comprehensive Cancer Center with key collaborators at the University of Kentucky, and University of Minnesota propose to develop a novel stem cell graft engineering approach that will address the known li National Institutes of Health 9/28/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $500,000 Trans-NIH Recovery Act Research Support The purpose of this proposal is to seek funds for the purchase of an LTQ OrbiTrap XL Mass Spectrometer. This instrument will expand and upgrade mass spectrometry capabilities within the Northeastern Ohio region, advancing research programs within the Clev National Institutes of Health 3/25/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $500,000 Trans-NIH Recovery Act Research Support The proposed work in this shared instrumentation grant application comes from many of the clinical and/or translational research programs ongoing at the Cleveland Clinic, a major research institution in the northeast Ohio region. The purpose of this appli National Institutes of Health 3/11/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $500,000 Trans-NIH Recovery Act Research Support The Imaging Core of the Cleveland Clinic Lerner Research Institute and a group of fifteen NIH- funded investigators request funds to purchase a spinning disk confocal microscope system for live-cell imaging - specifically the Perkin Elmer Ultraview Vox Sy National Institutes of Health 5/27/2010
CASE WESTERN RESERVE UNIVERSITY $446,961 Trans-NIH Recovery Act Research Support This pilot project will define the innate immune pathways critical for host response to a Category A biodefense pathogen, Rift Valley Fever Virus (RVFV), by elaborating molecular components of early cellular responses to RVFV in vitro, using established h National Institutes of Health 7/17/2009
CASE WESTERN RESERVE UNIVERSITY $439,930 Trans-NIH Recovery Act Research Support The goal of the parent grant is to investigate protein-ligand and protein-protein interactions in HIV-1 reverse transcriptase (RT). Being a key player in HIV infection, RT is the molecular target of the majority of AIDS drugs. The biologically active en National Institutes of Health 9/30/2009
CASE WESTERN RESERVE UNIVERSITY $432,405 Trans-NIH Recovery Act Research Support This study will define mucosal virulence and mechanism of innate immune host defense against aerosolized Rift Valley fever virus, a Category A biodefense pathogen. Rift Valley Fever virus (RVFV) is designated a priority pathogen based upon its projected s National Institutes of Health 9/01/2009
CASE WESTERN RESERVE UNIVERSITY $431,750 Trans-NIH Recovery Act Research Support Premature birth is a major public health problem that causes 70-80% of neonatal morbidity and mortality. To address this problem our research focuses on understanding the hormonal control of labor and in particular how the steroid hormone progesterone act National Institutes of Health 4/30/2009
CASE WESTERN RESERVE UNIVERSITY $431,750 Trans-NIH Recovery Act Research Support Dose of Early Therapeutic Mobility: Does Type and Frequency of Activity Matter? Abstract Early therapeutic mobility (ETM) activity has been recommended to facilitate recovery and improve outcomes, particularly for the one million survivors of critical ill National Institutes of Health 4/29/2009
CASE WESTERN RESERVE UNIVERSITY $431,750 Trans-NIH Recovery Act Research Support Candida albicans (CA) is the most commonly isolated fungus associated with biofilms [extracellular matrix (ECM)-encased microbial communities formed on indwelling medical devices which are resistant against commonly used antifungals. The carbohydrate-rich National Institutes of Health 5/29/2009
CASE WESTERN RESERVE UNIVERSITY $431,750 Trans-NIH Recovery Act Research Support This award will investigate the mechanisms regulating the maintenance of hyporesponsiveness in mucosal T cells and the environmental signals that enable this normally quiescent mucosal T cell to respond when needed. Signal transduction emanating from the National Institutes of Health 9/01/2009
CASE WESTERN RESERVE UNIVERSITY $431,750 Trans-NIH Recovery Act Research Support DNA nanoparticles self assemble from plasmid DNA and CK30 covalently linked to polyethylene glycol, and effectively transfect airway epithelium, retina, and neurons, but how they access cells has been obscure. Recently the surface receptor for these DNA n National Institutes of Health 5/29/2009
CASE WESTERN RESERVE UNIVERSITY $431,018 Trans-NIH Recovery Act Research Support Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a founding member of a new family of transcriptional modulators. My laboratory cloned Cited2 and showed that Cited2 is induced by many biological sti National Institutes of Health 7/17/2009
CASE WESTERN RESERVE UNIVERSITY $428,948 Trans-NIH Recovery Act Research Support The mucosal surfaces of the body are the portal of entry for many pathogenic micro- organisms yet most licensed vaccines are delivered parenterally and are ineffective at inducing mucosal immune responses. In addition, exposure of mucous membranes to most National Institutes of Health 9/26/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $426,620 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Basophils are now recognized as critical effectors and immune modulators during Th2 mediated immune responses, such as allergic inflammations and parasite infections. Evidence suggests that basophils produce Th2 induci National Institutes of Health 7/22/2009
CASE WESTERN RESERVE UNIVERSITY $418,365 Recovery Act Comparative Effectiveness Research - AHRQ Bipolar is a severe and lifelong illness affecting 4.5% of the population ? about 14 million people in the U.S. It is one of the top 10 most disabling medical conditions worldwide according to the World Health Organization. Traditionally, the moo... Show more
This spending item is part of a $9,784,863 allocation. See details
Agency for Healthcare Research and Quality 9/28/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $415,578 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (06): Enabling Technologies and specific Challenge Topic, 06-HL-103: Develop new imaging methodologies to track cells and measure accurately the chemical activities of en National Institutes of Health 9/21/2009
CASE WESTERN RESERVE UNIVERSITY $415,000 Trans-NIH Recovery Act Research Support The aim of this proposal is for the Case Western Reserve University (Case Comprehensive Cancer Center) to acquire an imaging cytometer, the Amnis ImageStream to expand the flow cytometry capabilities at the Case Comprehensive Cancer Center, Case Western R National Institutes of Health 5/21/2009
CASE WESTERN RESERVE UNIVERSITY $413,097 Trans-NIH Recovery Act Research Support This is a multi-PI RO1 grant designed to use multiple mouse genetic models of neural tube defects (NTDs, spina bifida and anencephaly) to investigate genetic factors confering NTD risk. Investigations will study how those gene mutations interact with envi
This spending item is part of a $2,366,335 allocation. See details
National Institutes of Health 8/04/2009
CASE WESTERN RESERVE UNIVERSITY $404,590 Trans-NIH Recovery Act Research Support Ribonucleotide Reductase, (RNR) is a multi-subunit enzyme that catalyzes the rate-limiting step of de novo precursor DMA synthesis by converting nucleotide diphosphates to deoxynucleotide diphosphates. Crucial for rapidly proliferating cells, RNR is a tar National Institutes of Health 8/31/2009
COUNCIL FOR ECONOMIC OPPORTUNITIES IN GREATER CLEVELAND $401,917 ARRA - Head Start This award provides for ARRA Cost of Living Adjustment(COLA) and Quality Improvement Funding consistent with the provisions of Section 640 (a) (5) of the Head Start Act for the Head Start and Early Head Start program. Head Start promotes the school read
This spending item is part of a $2,452,629 allocation. See details
Administration for Children and Families 7/14/2009
CASE WESTERN RESERVE UNIVERSITY $400,021 Trans-NIH Recovery Act Research Support This award responds to RFA-CA-08-504 which is intended to continue support for Phase 1 and 2 treatment studies in adults with primary central nervous system cancers and to continue the activities that were funded initially under RFA CA-04-001. This single
This spending item is part of a $885,989 allocation. See details
National Institutes of Health 7/17/2009
CASE WESTERN RESERVE UNIVERSITY $399,761 Trans-NIH Recovery Act Research Support This Competitive Revision Application is in response to Notice Number (NOT-OD-09-058) - Recovery Act Funds for Competitive Revision Applications. In this competitive revision application, we are adding a new set of resources to an existing P30 grant, Cent National Institutes of Health 9/18/2009
COUNCIL FOR ECONOMIC OPPORTUNITIES IN GREATER CLEVELAND $397,779 ARRA - Head Start This award provides for ARRA Cost of Living Adjustment(COLA) and Quality Improvement Funding consistent with the provisions of Section 640 (a) (5) of the Head Start Act for the Head Start and Early Head Start program. Head Start promotes the school read
This spending item is part of a $2,452,629 allocation. See details
Administration for Children and Families 7/14/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $392,500 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Many systemic autoimmune diseases are more common in females than in males. This is particularly evident in Sjvgren's Syndrome, systemic lupus erythromatosis (SLE) and thyroid autoimmunity, where the ratio of females t National Institutes of Health 6/18/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $392,500 Trans-NIH Recovery Act Research Support The public health issues, economic impact and human suffering associated with alcohol abuse are staggering. Although alcohol-related research has been on-going for decades, there are many unanswered questions concerning mechanisms of alcohol-induced tissu National Institutes of Health 8/24/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $392,500 Trans-NIH Recovery Act Research Support The overall objective of this application is to investigate the oxidation/reduction-regulated cellular and molecular mechanisms providing the homeostatic control of interleukin (IL)- 4-mediated signal transduction, gene expression, and immune responses. T National Institutes of Health 7/06/2010
CASE WESTERN RESERVE UNIVERSITY $392,500 Trans-NIH Recovery Act Research Support Innovative therapies to eliminate persistent HIV infection ARRA Project 1: Novel Therapeutics to Target HIV Latency -Evaluate novel HIV inducer activity in vitro and in vivo -Perform molecular profiling studies of novel inducers of HIV expression biomark
This spending item is part of a $2,685,074 allocation. See details
National Institutes of Health 9/01/2009
CASE WESTERN RESERVE UNIVERSITY $383,232 Trans-NIH Recovery Act Research Support The overall goal of this application is to understand biochemical mechanisms that underlie the function of rhesus monkey TRIM5 (rhTRIM5). rhTRIM5 blocks HIV-1 infection by acting at two or more post-entry stages. Importantly, rhTRIM5 E3 ubiquitin ligase a National Institutes of Health 1/19/2010
CASE WESTERN RESERVE UNIVERSITY $376,079 Trans-NIH Recovery Act Research Support The objectives of this research project are to synthesize and develop novel targeted nanoglobular gadolinium(III) chelates as safe, effective and tumor-specific contrast agents for diagnostic cancer imaging with magnetic resonance imaging (MRI). The FDA a National Institutes of Health 9/15/2009
CASE WESTERN RESERVE UNIVERSITY $367,306 ARRA - Nurse Faculty Loan Program The Nurse Faculty Loan Program provides funds to eligible schools of nursing that offer advanced education nursing programs to prepare graduates to serve as faculty in a school of nursing. The schools use the funds to establish distinct NFLP fund account Health Resources and Services Administration 8/12/2009
CASE WESTERN RESERVE UNIVERSITY $354,752 Trans-NIH Recovery Act Research Support This grant is to study basic mechanisms of bacterial Ag processing with a primary focus on MHC-I cross processing. MTB is selected as a model organism that represents an excellent model for processing of intravacuolar pathogens in addition to its signific National Institutes of Health 9/21/2009
CASE WESTERN RESERVE UNIVERSITY $350,429 ARRA Grants for Training in Primary Care Medicine and Dentistry Training and Enhancement Training in Primary Care Medicine and Dentistry:Physician Faculty Development in Primary Care. The overall purpose of the award is to enhance the faculty development of community clinical preceptors. These prece... Show more Health Resources and Services Administration 7/15/2010
BIOINVISION INC. $349,125 Trans-NIH Recovery Act Research Support We are poised to greatly benefit from an administrative supplement to develop cryo-imaging. We have made significant progress towards specific aims, including the creation of software and a prototype at BioInVision, Inc. We have also demonstrated exciting National Institutes of Health 9/29/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $331,022 Trans-NIH Recovery Act Research Support Choroidal neovascularization (CNV) is the major cause of severe vision loss in patients with age-related macular degeneration (AMD). The neovascularization originates from the choriocapillaris and grows through Bruch's membrane, into the sub-retinal pigme National Institutes of Health 9/23/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $323,623 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): The broad, long-term objective of this proposal is to define in molecular terms the linkage between the oxidative modifications of proteins in the outer retina, their recognition by the immune system and the vulnerabil National Institutes of Health 9/30/2009
CASE WESTERN RESERVE UNIVERSITY $314,000 Trans-NIH Recovery Act Research Support This award was made to fund two pilot projects for two years at $50,000 a year. These pilots will advance our understanding of the role of role of hypoxia in the etiology, pathogenesis, and treatment of cancer and the growth and migration of cancer stem National Institutes of Health 9/22/2009
CASE WESTERN RESERVE UNIVERSITY $310,860 Trans-NIH Recovery Act Research Support 15-PGDH is a prostaglandin degrading enzyme that my laboratory, in a recent from the cover PNAS paper, has shown is a new candidate colon cancer suppressor gene that acts as an enzymatic antagonist of the COX-2 prostaglandin synthesizing colon cancer onco National Institutes of Health 8/28/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $300,551 We have been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically to establish a Tissue Source Site (TSS) Network capable of delivering clinically annotated biospecimens through either or both retr
This spending item is part of a $2,725,275 allocation. See details
National Institutes of Health 9/27/2010
CASE WESTERN RESERVE UNIVERSITY $299,202 Trans-NIH Recovery Act Research Support North American AIDS Cohorts Collaboration on Research and Design A disturbing increase in the incidence of non-AIDS-defining conditions including renal disease, metabolic and cardiovascular disease, and malignancies has been observed in recent years, and
This spending item is part of a $7,312,062 allocation. See details
National Institutes of Health 9/21/2009
METROHEALTH SYSTEM, THE $298,000 ARRA ? Equipment to Enhance Training for Health Professionals To expand the pediatric dental residency program through the purchase of equipment needed to increase the number of clinical operatories. Health Resources and Services Administration 9/01/2010
COUNCIL FOR ECONOMIC OPPORTUNITIES IN GREATER CLEVELAND $296,220 ARRA - Head Start This award provides for ARRA Cost of Living Adjustment(COLA) and Quality Improvement Funding consistent with the provisions of Section 640 (a) (5) of the Head Start Act for the Head Start and Early Head Start program. Head Start promotes the school read
This spending item is part of a $2,452,629 allocation. See details
Administration for Children and Families 7/14/2009
CARE ALLIANCE $290,859 ARRA Health Center Integrated Services Development Initiative[g1] IDS project will enable us to increase health center staffing, specifically in the dental department through the addition of 0.6 FTE dentist, 0.2 FTE hygienist and 1 FTE dental assistants. Because of the unique population Care Alliance... Show more Health Resources and Services Administration 3/27/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $286,955 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Hypertension, or high blood pressure, is the most prevalent cardiovascular disease, afflicting nearly one in every three American adults. The prevalence of this disease is even higher in African-Americans but the under National Institutes of Health 7/16/2009
CASE WESTERN RESERVE UNIVERSITY $275,357 Trans-NIH Recovery Act Research Support Important concerns have been raised about the ethics of phase 1 clinical trials in oncology. In previous research, many patients have reported high expectations of personal clinical benefit from phase 1 trials. In the project leading to this application (
This spending item is part of a $674,806 allocation. See details
National Institutes of Health 6/04/2009
CASE WESTERN RESERVE UNIVERSITY $273,420 Trans-NIH Recovery Act Research Support This continuation of funding for the Cleveland Pediatric Pharmacology Research Unit (PPRU) which was first funded in 1994, one year after the establishment of the PPRU and has been funded since then at a level one-half to two thirds that of the other unit National Institutes of Health 7/16/2009
CASE WESTERN RESERVE UNIVERSITY $266,837 Trans-NIH Recovery Act Research Support Recent studies suggest that excess lipid accumulation may play an important role in the pathophysiology of heart failure (HF), obesity, insulin resistance and diabetes. The cellular mechanisms that determine whether excess lipid accumulation is well toler National Institutes of Health 7/16/2009
CASE WESTERN RESERVE UNIVERSITY $265,139 Trans-NIH Recovery Act Research Support This award is for cryoelectron microscopy structural studies of complexes of a human virus with a peptide of the innate immune system with the goal of understanding the mechanism of viral neutralization. Adenovirus is a common human pathogen and engineere National Institutes of Health 6/08/2012
CASE WESTERN RESERVE UNIVERSITY $258,500 Trans-NIH Recovery Act Research Support Arterial baroreceptors (BR) are essential for reliable neural control of heart rate and blood pressure. The data quantifying the properties of these pressoreceptors and the reflexogenic consequences of BR function and dysfunction are extensive. Experiment
This spending item is part of a $808,068 allocation. See details
National Institutes of Health 6/01/2009
CASE WESTERN RESERVE UNIVERSITY $258,343 Trans-NIH Recovery Act Research Support This longitudinal study addresses the relationship between birth weight and early childhood caries (ECC) in a cohort of pre-term very low birth weight (VLBW) and full-term normal birth weight (NBW) infants. VLBW and ECC disproportionately affects poor and National Institutes of Health 9/22/2009
CASE WESTERN RESERVE UNIVERSITY $257,592 Trans-NIH Recovery Act Research Support The project continues a productive and successful program of strongly collaborative studies on the biomedical consequences of lipid oxidation. It focuses on the role of lipid-derived oxidative protein and ethanolamine phospholipid modification in eye dise National Institutes of Health 7/30/2010
CASE WESTERN RESERVE UNIVERSITY $257,300 Trans-NIH Recovery Act Research Support The aims of this project are to accelerate the development of post-doctoral trainees in global health research, taking advantage of existing research programs and the Framework program at Case Western Reserve University (CWRU) and expanding existing relat National Institutes of Health 9/26/2010
Western Reserve Area Agency On Aging $255,361 Aging Home-Delivered Nutrition Services for States The Administration on Aging has made additional nutritionfunds available for home-delivered meals. These funds support community programs that provide nutritious meals to individuals age 60 and older.
This spending item is part of a $1,232,050 allocation. See details
Administration on Aging 3/18/2009
CASE WESTERN RESERVE UNIVERSITY $253,614 Trans-NIH Recovery Act Research Support The ARRA Award provides supplemental funding for the Molecular Therapeutics Training Program (MTTP), specifically to support three additional trainees for the two-year period, Sept. 1, 2009 G?? Aug. 31, 2011. The global objective of the MTTP is to provid National Institutes of Health 8/13/2009
CASE WESTERN RESERVE UNIVERSITY $251,298 Trans-NIH Recovery Act Research Support This award is a supplemental grant to the Center of Research Translation (PI: Kevin Cooper), to enable the conduct of FDA-required animal/pre-clinical toxicologic studies on the investigational drug silicon phthalocyanine Pc 4. One of the goals of the COR National Institutes of Health 9/18/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $251,181 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Pelvic floor disorders (PFD) including urinary incontinence, pelvic organ prolapse (POP), and fecal incontinence affect a substantial proportion of women in the U.S. PFD result in significant psychosocial costs to an i National Institutes of Health 9/29/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $250,814 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is a complex arrhythmia that afflicts more than 2.3 million Americans. Most prevalent in the elderly, AF is associated with a 2-fold higher risk for mortality. AF is the most potent risk factor National Institutes of Health 7/16/2009
CASE WESTERN RESERVE UNIVERSITY $243,763 Trans-NIH Recovery Act Research Support Differences in the pattern of gene expression between normal brain and its tumors of glial origin can provide information useful for malignant glioma diagnosis and therapy. These tumors cannot be diagnosed until they become visible on MRI scans and cannot National Institutes of Health 8/27/2009
CASE WESTERN RESERVE UNIVERSITY $243,591 Trans-NIH Recovery Act Research Support The Coordinating and Bioinformatics Unit (CBU) for the Animal Models of Diabetic Complications Consortium (AMDCC) and the Mouse Metabolic Phenotyping Centers (MMPC) is responsible for creating and maintaining the administrative, scientific and informatics
This spending item is part of a $1,819,749 allocation. See details
National Institutes of Health 9/28/2009
CASE WESTERN RESERVE UNIVERSITY $238,652 Trans-NIH Recovery Act Research Support Osteoarthritis (OA) is the most common musculoskeletal disease among the aging population in the United States and throughout the world. OA is characterized by degeneration of articular cartilage of the joints in hands, knees, spine and hips. While condit National Institutes of Health 5/04/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $235,500 Trans-NIH Recovery Act Research Support Overall, these proposed studies are of importance to understand pancreatic progenitor maintenance and specification, and will directly impact studies of regenerative medicine for diabetes and treatment modalities for pancreatic cancer. They are also rel National Institutes of Health 1/20/2010
CASE WESTERN RESERVE UNIVERSITY $235,500 Trans-NIH Recovery Act Research Support Sushi domain containing protein 4 (SUSD4) is a highly conserved (> 95% homology in mammals) hypothetical protein with unknown function. Previous microarray based comparative genomic hybridization (cGH) studies suggested that deletion of SUSD4 gene could National Institutes of Health 9/27/2010
CASE WESTERN RESERVE UNIVERSITY $235,125 Trans-NIH Recovery Act Research Support Activating mutations in FGFR2 cause craniosynostosis syndromes such as Apert and Crouzon syndromes. Recent genetic evidence has also indicated that the ERK MAPK pathway and immediate early genes play critical roles in the regulation of bone formation. The National Institutes of Health 9/17/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $234,751 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Beta-adrenergic receptor (bAR) signaling is one of the most powerful regulators of cardiac function. In human heart failure, diminished receptor numbers at the plasma membrane associated with impaired G-protein couplin National Institutes of Health 7/16/2009
CASE WESTERN RESERVE UNIVERSITY $220,022 Trans-NIH Recovery Act Research Support The serpin class of protease inhibitors includes many of the protease inhibitors in blood, such as antithrombin and alpha-1 antitrypsin. Serpins are involved in the regulation of many physiological processes including fibrinolysis, complement activation, National Institutes of Health 7/20/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $219,888 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Recent studies indicate that platelet activation plays an important role in all stages of atherosclerotic lesion formation: initiation, progression, stability and thrombosis triggered by plaque rupture. Another event t National Institutes of Health 7/16/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $216,437 Trans-NIH Recovery Act Research Support The overall aim of this project is to clarify the relationship between neuronal activity in the internal segment of the globus pallidus (GPi) and the development, phenotypic distribution and severity of dystonic movements in patients with primary generali National Institutes of Health 9/26/2009
CLEVELAND STATE UNIVERSITY $213,000 Trans-NIH Recovery Act Research Support Programmed cell death (apoptosis) is induced concomitant with differentiation in skeletal myoblasts and other systems. In skeletal myoblasts, these two processes result in mutually exclusive physiologically important endpoints. However, the coordinate t National Institutes of Health 9/29/2009
NEIGHBORHOOD HEALTH CARE INC $208,004 ARRA Health Center Integrated Services Development Initiative[g1] The award money is being used for salaries and fringe benefits for new staff to accomodate the increased demand for services in the community. The 3.67 FTE's were hired in July 2009: A Medical Doctor at .67 FTE was hired July 27, 2009.... Show more Health Resources and Services Administration 3/27/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $194,176 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): This proposal addresses Challenge Area 15: Translational Science, and Specific Challenge Topic: Demonstration of proof-of-concept for a new therapeutic approach in a neurological disease: 15-NS-103. Parkinson's disease National Institutes of Health 9/28/2009
CASE WESTERN RESERVE UNIVERSITY $193,700 Trans-NIH Recovery Act Research Support The aim of the proposed research is to define how genetic loss of MeCP2, the gene responsible for Rett Syndrome (Rett), disrupts Brain Derived Neurotrophic Factor (BDNF) signaling in autonomic reflex pathways in the brainstem nucleus tractus solitarius (n National Institutes of Health 9/21/2009
CASE WESTERN RESERVE UNIVERSITY $191,352 Trans-NIH Recovery Act Research Support The techniques of chromatin immunoprecipitation coupled with DNA microarray (ChIP-chip) and sequencing (ChIP-seq) have gained widespread popularity among the greater scientific community. The data generated from such analyses have begun to provide valuabl National Institutes of Health 8/28/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $188,455 Trans-NIH Recovery Act Research Support Description (provided by the applicant): Coagulation factors V (FV) and factor VIII (FVIII) are both secreted glycoproteins that share pivotal roles in both hemostasis and thrombosis. Although many secreted proteins (referred to as cargo) are believed to National Institutes of Health 8/01/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $187,320 Trans-NIH Recovery Act Research Support The long term goals of this grant are to test mechanisms of pain transmission in the spinal cord of humans and to test whether experimental pain models in animals and humans predict efficacy of spinal analgesics in clinical pain states. We focus on the sp
This spending item is part of a $207,458 allocation. See details
National Institutes of Health 9/25/2009
CASE WESTERN RESERVE UNIVERSITY $185,411 Trans-NIH Recovery Act Research Support The goal of this research is to develop and clinically implement a new method of quickly and reversibly blocking the conduction of action potentials in peripheral nerve. In our currently funded project, we have demonstrated that high frequency alternating National Institutes of Health 8/13/2009
Cleveland Clinic Educational Foundation (inc) $184,915 Trans-NIH Recovery Act Research Support Patient recruitment and retention Patient recruitment and retention of study subjects has been excellent in this study. The COMET Network was able to screen 108 potential subjects. From these there were 12 screen fails, 3 subjects withdrew consent, two
This spending item is part of a $7,915,507 allocation. See details
National Institutes of Health 9/28/2009
CASE WESTERN RESERVE UNIVERSITY $181,321 Trans-NIH Recovery Act Research Support The long term goal of this proposal is to understand, in detail, the process of cessation of mRNA translation. We have uncovered compelling evidence that shutting down mRNA translation is not simply a passive and default event in the lifetime of an mRNA, National Institutes of Health 8/10/2009
Cleveland Clinic Educational Foundation (inc) $180,113 Trans-NIH Recovery Act Research Support Patient recruitment and retention Patient recruitment and retention of study subjects has been excellent in this study. The COMET Network was able to screen 108 potential subjects. From these there were 12 screen fails, 3 subjects withdrew consent, two
This spending item is part of a $7,915,507 allocation. See details
National Institutes of Health 9/28/2009
CASE WESTERN RESERVE UNIVERSITY $177,830 Trans-NIH Recovery Act Research Support Our long term aim is to use a genetic approach in Drosophila to understand molecular mechanisms of motorneuron fate specification and differentiation. In this proposal, we focus on mechanisms linking motorneuron fate to axon guidance. In a large-scale scr National Institutes of Health 8/17/2009
APPLIED TECHNOLOGY SYSTEMS, INC. $175,000 Trans-NIH Recovery Act Research Support The Gulf Coast Transdisciplinary Research Recovery Center for Community Health brings together outstanding academic and public health institutions and centers as a Consortium. The Consortium will coordinate new research studies and projects with existing
This spending item is part of a $4,000,000 allocation. See details
National Institutes of Health 9/30/2009
CASE WESTERN RESERVE UNIVERSITY $168,113 Trans-NIH Recovery Act Research Support We have spent the last two to three years developing a system by which specific cell types can be eliminated in the developing or adult CNS with close spatial and temporal control in the absence of any local insults to the tissue. In the original grant National Institutes of Health 9/25/2009
Rapid Medical Research Inc $160,000 The contractor shall furnish all necessary facilities, equipment, materials, and personnel, and shall perform all services necessary to conduct three clincial studies entitled FUF14 - H1N1 Adult/Ederly Clinical Study; FUF15 - H1N1 Pediatric Clinical Study
This spending item is part of a $29,360,000 allocation. See details
Office of Assistant Secretary for Administration and Management 9/30/2009
CASE WESTERN RESERVE UNIVERSITY $159,644 Trans-NIH Recovery Act Research Support The long term goal of the proposed research is to understand, in detail, the role of spliceosomal snRNAs in catalysis of the splicing reaction. In the active spliceosome, U6 and U2 snRNAs form a base-paired complex that helps position the reactants of the National Institutes of Health 9/18/2009
COUNCIL FOR ECONOMIC OPPORTUNITIES IN GREATER CLEVELAND $158,551 ARRA - Head Start This award provides for ARRA Cost of Living Adjustment(COLA) and Quality Improvement Funding consistent with the provisions of Section 640 (a) (5) of the Head Start Act for the Head Start and Early Head Start program. Head Start promotes the school read
This spending item is part of a $2,452,629 allocation. See details
Administration for Children and Families 7/14/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $157,000 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Patient motion is a major issue in nuclear medicine imaging studies, which require substantial time to acquire enough counts to produce clinical-quality images. Motion correction algorithms exist but have limited accur National Institutes of Health 7/17/2009
CASE WESTERN RESERVE UNIVERSITY $157,000 Trans-NIH Recovery Act Research Support Epidemiological studies and clinical observations suggest that persistent chronic inflammation is important in prostate carcinogenesis. The chronic inflammatory lesions frequently observed in prostate tissue biopsies and radical prostatectomy specimens ar National Institutes of Health 7/16/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $157,000 Trans-NIH Recovery Act Research Support Memory T cells specific for donor antigens present a unique challenge in transplantation. While memory T cells augment host protection upon re-infection, donor-reactive memory T cells lead to robust immune responses to a transplanted organ translating int National Institutes of Health 6/28/2010
Rapid Medical Research Inc $154,800 The contractor shall furnish all necessary facilities, equipment, materials, and personnel, and shall perform all services necessary to conduct three clincial studies entitled FUF14 - H1N1 Adult/Ederly Clinical Study; FUF15 - H1N1 Pediatric Clinical Study
This spending item is part of a $29,360,000 allocation. See details
Office of Assistant Secretary for Administration and Management 9/30/2009
CASE WESTERN RESERVE UNIVERSITY $150,674 Trans-NIH Recovery Act Research Support The goal of this project is to develop a multiple channel peripheral nerve electrode capable of selective detection of fascicular nerve activity. This goal will be accomplished with four specific aims: Aim 1: Forward model of the nerve cuff interface. Aim National Institutes of Health 9/30/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $150,199 Trans-NIH Recovery Act Research Support Chronic pancreatitis, a destructive disease of the pancreas, is difficult to diagnosis and can present with a variety of symptoms. The incidence of chronic pancreatitis is not known; hospital admission and discharge summaries suggest at least 60,000 pati
This spending item is part of a $1,529,793 allocation. See details
National Institutes of Health 9/25/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $149,966 Trans-NIH Recovery Act Research Support Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are important causes of chronic liver disease in the United States. The NASH Clinical Research Network (NASH CRN) was established in 2002 to conduct research related to its c National Institutes of Health 1/25/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $143,203 Trans-NIH Recovery Act Research Support Cell migration is essential for many aspects of normal embryonic development as well as in wound healing in the adult. Failure of cells to migrate contributes to birth defects and difficulties in wound healing, whereas unregulated cell migration triggers National Institutes of Health 9/18/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $141,300 Trans-NIH Recovery Act Research Support Our long-range goal is to understand the cellular and molecular mechanisms of endothelial dysfunction in order to elucidate new targets for pharmacological intervention that will prevent and/or minimize vascular complications of disease. Targeting genes o
This spending item is part of a $423,950 allocation. See details
National Institutes of Health 5/15/2009
CLEVELAND MEDICAL DEVICES INC. $139,411 Trans-NIH Recovery Act Research Support The objective is to design, build, and clinically assess ParkinTune, an advanced wireless movement disorder technology to augment stimulation programming (tuning) involved in deep brain stimulation (DBS) procedures for Parkinson?s Disease (PD). Major PD s National Institutes of Health 9/29/2009
CLEVELAND MEDICAL DEVICES INC. $139,411 The objective is to design, build, and clinically assess ParkinTune?, an advanced wireless movement disorder technology to augment stimulation programming (tuning) involved in deep brain stimulation (DBS) procedures for Parkinson?s Disease (PD). Major PD National Institutes of Health 9/29/2009
CASE WESTERN RESERVE UNIVERSITY $136,234 Trans-NIH Recovery Act Research Support Mg chemistry is unique among biological cations, and cells possess novel mechanisms for regulating Mg2+ and facilitating its passage through membranes. This proposal focuses on the CorA Mg2+ transporter, the primary Mg2+ uptake system for most Eubacteria National Institutes of Health 8/31/2009
CASE WESTERN RESERVE UNIVERSITY $135,460 Trans-NIH Recovery Act Research Support The CFAR Network of Integrated Clinical Systems (CNICS), headquartered at UAB, was funded in September 2006 via the R24 mechanism. This supplement is to fund increased capacity for sample repositorys at UAB and each of the designated CNICS sites through
This spending item is part of a $1,825,789 allocation. See details
National Institutes of Health 9/21/2009
CASE WESTERN RESERVE UNIVERSITY $134,681 Trans-NIH Recovery Act Research Support The purpose of this administrative supplement is to develop the genetic tools necessary to determine the mechanism by which PPS (CG6525) contributes to Sex-lethal splicing autoregulation. These studies fall under the auspices of Aim 1 of the parent grant. National Institutes of Health 8/31/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $122,787 Trans-NIH Recovery Act Research Support Chronic pancreatitis, a destructive disease of the pancreas, is difficult to diagnosis and can present with a variety of symptoms. The incidence of chronic pancreatitis is not known; hospital admission and discharge summaries suggest at least 60,000 pati
This spending item is part of a $1,529,793 allocation. See details
National Institutes of Health 9/25/2009
CASE WESTERN RESERVE UNIVERSITY $121,129 Trans-NIH Recovery Act Research Support Title: Blood and Mucosal HIV-spcific CD8+ T Cell Responses in High-Risk Seronegatives The mechanisms responsible for the apparent resistance of certain persons to HIV infection despite re National Institutes of Health 6/28/2010
CASE WESTERN RESERVE UNIVERSITY $120,472 Trans-NIH Recovery Act Research Support G?The Chronic Renal Insufficiency Cohort study is a longitudinal observational study of patients with chronic kidney disease. An important goal of the study is is evaluate the relationship between kidney function and cardiovascular disease. To accomplish National Institutes of Health 9/21/2009
CASE WESTERN RESERVE UNIVERSITY $117,657 Trans-NIH Recovery Act Research Support Inhibition or lack of axon guidance affects neuronal cell motility and positional maintenance, resulting in the failure to regenerate neurona! connections after injury. Defective guidance is also associated with diseases ranging from Alzheimers to cancer. National Institutes of Health 7/17/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $116,180 Trans-NIH Recovery Act Research Support Severe asthma, a heterogeneous disease consisting of related clinical phenotypes, generates high levels of morbidity, mortality and health care costs. The complexity and heterogeneity of the disorder have limited clinical advances. However, the NHLBI Seve
This spending item is part of a $3,489,267 allocation. See details
National Institutes of Health 9/25/2009
CASE WESTERN RESERVE UNIVERSITY $111,096 Trans-NIH Recovery Act Research Support This administrative supplement to 1U10HD63072-01 (Adverse Outcomes In Nulliparous Pregnancies: The Ohio Collaborative) proposes to administer questionaires investigating novel factors associated with adverse pregnancy outcomes and to perform cervical len National Institutes of Health 7/08/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $110,658 Trans-NIH Recovery Act Research Support The establishment of an intimate interaction between the long retinal pigment epithelium (RPE) microvilli and the mature photoreceptor outer segments is essential for vision. The RPE performs highly specialized, unique functions essential for homeostasis National Institutes of Health 7/01/2010
THE CLEVELAND CLINIC FOUNDATION $109,900 Trans-NIH Recovery Act Research Support The proposed application under this challenge grant seek to answer the following questions: (1) What is the incremental cost-effectiveness of SPECT, PET, and CCTA as well as their respective accuracy for identification of obstructive CAD, and clinical eve
This spending item is part of a $994,862 allocation. See details
National Institutes of Health 9/23/2009
CASE WESTERN RESERVE UNIVERSITY $108,000 Trans-NIH Recovery Act Research Support There is a serious gap nationwide in the number of individuals whose training emphasizes global health issues. The number of professionals with firsthand experience in global health issues is critically low. The overall objective of the Case Framework Pro National Institutes of Health 9/03/2009
CASE WESTERN RESERVE UNIVERSITY $108,000 Trans-NIH Recovery Act Research Support The proposed project will be performed in the areas of tyrosine kinases, cytoskeleton, and invasion/metastasis in SCLC. My long term career goal is to become an independent clinician-scientist in translational cancer research with focus on targeted therap National Institutes of Health 9/15/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $107,974 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Multiple cell types are involved in the development and persistence of chronic inflammatory response. This also occurs in inflammatory bowel disease (IBD), where long-standing activation of immune and non-immune cells National Institutes of Health 9/16/2009
CASE WESTERN RESERVE UNIVERSITY $107,200 Trans-NIH Recovery Act Research Support Our goal is to sketch out the broad principles by which these ncRNAs acquire activity from structure, which will provide a foundation to develop new therapeutic agents and the next generation of antibiotics. Non-protein-coding (nc)RNAs are undergoing
This spending item is part of a $673,524 allocation. See details
National Institutes of Health 9/30/2009
CASE WESTERN RESERVE UNIVERSITY $102,050 Trans-NIH Recovery Act Research Support The purpose of this supplement is to develop a rapid and high throughput diagnostic test for identifying mutations in the CHD7 gene. We expect the test to facilitate a quick and thorough evaluation of the extent of which CHD7 mutations contribute to human National Institutes of Health 7/08/2010
CASE WESTERN RESERVE UNIVERSITY $100,000 Trans-NIH Recovery Act Research Support In disease states, unfolded proteins accumulate in the endoplasmic reticulum because the folding capacity is exceeded, initiating a cellular stress response (the unfolded protein response or UPR). Our long-term interest is to understand the molecular mech National Institutes of Health 8/21/2009
CASE WESTERN RESERVE UNIVERSITY $100,000 Trans-NIH Recovery Act Research Support Vitamin E (Tocopherol) is the major fat-soluble antioxidant in humans, and serves a critical function in protection against a plethora of oxidative-stress-related pathologies. However, surprisingly little is known about the molecular mechanisms that regul National Institutes of Health 8/24/2009
CASE WESTERN RESERVE UNIVERSITY $100,000 Trans-NIH Recovery Act Research Support This proposal presents a multidisciplinary approach to understanding a fundamental property of sensory processing: the modulation of sensory perception by acetylcholine. The proposal addresses this question in the olfactory bulb of rats, using a combinati National Institutes of Health 8/14/2009
CASE WESTERN RESERVE UNIVERSITY $99,993 Trans-NIH Recovery Act Research Support Currently there is a major need in hematopoietic stem cell (HSC) transplantation to develop reduced intensity regimens that do not cause DNA damage and associated toxicities and that allow a wider range of patients to receive therapy. Cytokine receptor s National Institutes of Health 9/25/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $99,151 Trans-NIH Recovery Act Research Support The incidence of thyroid cancer is rising at the second fastest rate of all malignancies in the United States and has an increasing tumor-specific mortality annually, making it an important public health problem. The reasons for this increasing incidence
This spending item is part of a $409,868 allocation. See details
National Institutes of Health 9/16/2009
CASE WESTERN RESERVE UNIVERSITY $99,130 Trans-NIH Recovery Act Research Support Development in metazoans is regulated by specific regulatory hierarchies leading to the stage- and tissue-specific expression of transcriptional networks. Understanding such networks poses a major challenge in developmental biology. A model is provided by National Institutes of Health 1/08/2010
CASE WESTERN RESERVE UNIVERSITY $98,910 Trans-NIH Recovery Act Research Support Prolonged mild hypoxia initiates a sequence of vascular and metabolic adaptations in the rat brain. Angiogenesis and the resultant increased capillary density that occurs over a 3 week time course is an important aspect of the adaptation process. The long National Institutes of Health 9/25/2009
CASE WESTERN RESERVE UNIVERSITY $98,170 Trans-NIH Recovery Act Research Support This Administrative Supplement application is in response to NOT-OD-09-056. The project is entitled G?Administrative Supplement: Equipment to Support Full Inclusion of Persons with Disabilities in Self-Management Research.G? Funds are for supplemental eq National Institutes of Health 5/13/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $97,822 Trans-NIH Recovery Act Research Support This is an ARRA Administrative Supplement proposal for U01DK062410 Polycystic Kidney Disease-Treatment Network (HALT PKD): Controlled Trials of Renin Angiotensin Blockade in Autosomal Dominant Polycystic Kidney Disease (ADPKD). The Mayo Clinic (with subco
This spending item is part of a $423,547 allocation. See details
National Institutes of Health 9/21/2009
CASE WESTERN RESERVE UNIVERSITY $97,705 Trans-NIH Recovery Act Research Support This award is to replace equipment in the PI's laboratory that is more than 15 years old and no longer functional. The equipment is a laser and photon detector that are used to obtain Raman spectra and is used by students and researchers in the Carey lab National Institutes of Health 9/25/2009
WESTERN RESERVE AREA AGENCY ON AGING $93,259 ARRA - Communities Putting Prevention to Work: Chronic Disease Self-Manage In collaboration with the Recovery Act-funded Communities Putting Prevention to Work (CPPW) program, this funding will support the deployment of evidence-based chronic disease self-managment programs that empower older people ... Show more
This spending item is part of a $1,000,000 allocation. See details
Administration on Aging 3/31/2010
CASE WESTERN RESERVE UNIVERSITY $92,194 Trans-NIH Recovery Act Research Support Currently, there are no specific high-affinity inhibitors or activators of mitochondrial ATP-dependent proteases. The identification of such compounds will allow us to determine the role that these proteases play in mitochondrial dysfunction, which is ass
This spending item is part of a $733,700 allocation. See details
National Institutes of Health 8/14/2009
URSULINE COLLEGE $89,216 ARRA - Scholarships for Disadvantaged Students Health Resources and Services Administration 6/14/2010
URSULINE COLLEGE $89,216 ARRA - Scholarships for Disadvantaged Students ARRA - Scholarships for Disadvantaged Students (Nursing) Health Resources and Services Administration 6/14/2010
CASE WESTERN RESERVE UNIVERSITY $88,000 Trans-NIH Recovery Act Research Support Hepatitis C virus (HCV) is the most common cause of chronic viral hepatitis in the United States, and is a significant cause of morbidity and mortality. The T cell response directed at HCV derived antigens is thought to be important in the pathogenesis of National Institutes of Health 1/21/2010
CELLULAR TECHNOLOGY LIMITED $84,320 LABORATORY EQUIPMENT National Institutes of Health 9/17/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $84,074 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Myosin II plays fundamental roles in cytokinesis, cell migration, and cell shape changes during development. In all these settings, it is well established that dynamic localized assembly of myosin into the cytoskeleton National Institutes of Health 9/30/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $80,755 Trans-NIH Recovery Act Research Support Lung transplant (LTx) is a viable treatment option for a variety of end-stage pulmonary parenchymal and vascular diseases. Advancements in surgery, immunosuppression and recipient selection have significantly improved perioperative survival following LTx.
This spending item is part of a $1,117,955 allocation. See details
National Institutes of Health 5/30/2009
CASE WESTERN RESERVE UNIVERSITY $80,484 Trans-NIH Recovery Act Research Support The mechanism underlying G protein-coupled receptor (GPCR)-mediated signaling systems is still unresolved despite the intense focus these systems have received over the past century. This is due in part to the difficulties in studying membrane proteins in National Institutes of Health 9/16/2009
CASE WESTERN RESERVE UNIVERSITY $80,000 Trans-NIH Recovery Act Research Support This award is a supplement to GM079191 (Structural Studies of G Protein) and has been provided for the express intent to purchase equipment related to this project. All funds related to this supplement have been fully expended. National Institutes of Health 2/12/2010
CASE WESTERN RESERVE UNIVERSITY $79,494 Trans-NIH Recovery Act Research Support The incidence of type 2 diabetes mellitus is rising, and therefore, so are the urological complications experienced by patients with type 2 diabetes. To increase our understanding of urological complications of diabetes, the principal investigator and his National Institutes of Health 9/15/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $79,128 Trans-NIH Recovery Act Research Support Cell magnetophoresis is a cell motion induced by the magnetic field in electrolyte solutions. During the current funding period (ending 01/31/08) we have used Cell Tracking Velocimetry (CTV) to compare effects of binding of various commercial immunomagnet
This spending item is part of a $128,397 allocation. See details
National Institutes of Health 9/01/2009
CASE WESTERN RESERVE UNIVERSITY $78,930 Trans-NIH Recovery Act Research Support This award is an adminstrative supplement for a T32 training grant that supports the Genetics Graduate Training Program at Case Western Reserve University (Case). The goal of the Genetics Training program at Case is to train pre-doctoral students in the u National Institutes of Health 8/13/2009
CASE WESTERN RESERVE UNIVERSITY $78,930 Trans-NIH Recovery Act Research Support This award is an adminstrative supplement for a T32 training grant that supports the Genetics Graduate Training Program at Case Western Reserve University (Case). The goal of the Genetics Training program at Case is to train pre-doctoral students in the u National Institutes of Health 8/13/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $78,772 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Breast cancer is responsible for the second overall cause of cancer-related deaths among women. Despite this profound health risk, Immunotherapy for breast cancer has not been adequately developed as an integral part o National Institutes of Health 9/30/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $76,899 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): The primary goal of this research is to understand communication, comprehension and decision-making in Phase I childhood cancer trials. The project will take place at 6 of the most active Phase I pediatric programs in
This spending item is part of a $160,519 allocation. See details
National Institutes of Health 8/31/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $76,679 Trans-NIH Recovery Act Research Support The overall goal of this project is to determine the role of oxidative stress with associated inflammation and abnormalities in nitric oxide synthase (NOS) in the pathogenesis of clinical cardiovascular disease (CVD), carotid IMT, cardiac MRI and microvas National Institutes of Health 5/03/2010
CASE WESTERN RESERVE UNIVERSITY $75,949 Recovery Act Comparative Effectiveness Research - AHRQ For Stage I Part 1, we extracted limited access data sets from APPLES including 106 data terms for which a data dictionary could be provided. These data were then used to enable, evaluate, and refine tools previously developed during the NCRR-sup... Show more
This spending item is part of a $8,309,936 allocation. See details
Agency for Healthcare Research and Quality 9/28/2010
CASE WESTERN RESERVE UNIVERSITY $75,600 Trans-NIH Recovery Act Research Support Abstract Serotonin (5-hydroxytryptamine; 5HT) has been demonstrated to play important roles in various physiological functions such as mood, sexual behavior, feeding, sleep/wake cycle, memory, cognition, blood pressure regulation and breathing (Mooney et National Institutes of Health 5/05/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $73,250 Trans-NIH Recovery Act Research Support This is a proposal to validate the accuracy of a multi-gene Lung Cancer Risk Test (LCRT). An accurate LCRT may be used to design more efficient lung cancer screening and/or chemoprevention studies by enabling enrollment of the highest risk individuals, re
This spending item is part of a $1,649,791 allocation. See details
National Institutes of Health 9/30/2009
CASE WESTERN RESERVE UNIVERSITY $72,609 Trans-NIH Recovery Act Research Support Decay accelerating factor (DAF) is a 70 kDa intrinsic membrane regulator that protects self cells from autologous complement-mediated injury. It functions by decaying the C3 central convertases (C4b2a and C3bBb), a process which determines whether complem National Institutes of Health 8/01/2009
CASE WESTERN RESERVE UNIVERSITY $71,871 Trans-NIH Recovery Act Research Support This proposal is the first step in a major paradigm shift leading to global acceptance of evidence-based protocol-driven care as the optimal approach to treatment of pediatric rheumatic diseases by families, patients, and health care providers. Through th
This spending item is part of a $6,824,989 allocation. See details
National Institutes of Health 9/30/2009
CASE WESTERN RESERVE UNIVERSITY $71,396 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): The innate immune system recognizes and responds to pathogenic organisms. In doing so, this system is responsible for initiating a cytokine response designed to tailor the adaptive immune system to eradicate the offend National Institutes of Health 8/10/2009
CASE WESTERN RESERVE UNIVERSITY $71,316 Trans-NIH Recovery Act Research Support This Administrative Supplement seeks support for an ongoing study of the social outcomes of childhood traumatic brain injury. The supplement will (1) accelerate the completion of the parent project by enabling increased recruitment and more rapid data cod
This spending item is part of a $261,793 allocation. See details
National Institutes of Health 7/30/2010
CASE WESTERN RESERVE UNIVERSITY $70,650 Trans-NIH Recovery Act Research Support In our proposed research we will develop a novel approach for magnetically-driven organization of ordered cellular structures without using microfabricated substrates, potentially harmful electrical fields, or the physical attachment to or uptake of mater
This spending item is part of a $235,078 allocation. See details
National Institutes of Health 7/16/2009
CASE WESTERN RESERVE UNIVERSITY $70,140 Trans-NIH Recovery Act Research Support Decreased levels of cell cycle inhibitor p27Kip1 due to excessive degradation occur in a variety of aggressive human tumors. Since reduced p27 expression has been associated with a poor prognosis in many human cancers and resistance to certain anti-tumor
This spending item is part of a $342,296 allocation. See details
National Institutes of Health 9/22/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $68,499 Trans-NIH Recovery Act Research Support Abdominal aortic aneurysms (AAAs), characterized by degrading aortic elastin matrix and resultant vessel weakening and rupture, causes 15,000 deaths in the United States anually, primarily amongst seniors, and those suffering from inherited matrix disorde
This spending item is part of a $102,379 allocation. See details
National Institutes of Health 7/29/2010
CLEVELAND STATE UNIVERSITY $67,938 Trans-NIH Recovery Act Research Support The synaptonemal complex (SC) is a proteinaceous scaffold that juxtaposes homologous chromosomes (homologs) during the pachytene stage of meiosis. Crossovers/chiasmata form in the context of the SC mediating homolog segregation to opposite spindle poles. National Institutes of Health 9/18/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $65,040 Trans-NIH Recovery Act Research Support The long-term objective of this proposal is to advance research in the area of physical activity promotion for persons with multiple sclerosis (MS) by implementing and evaluating a multifaceted intervention that can be translated into public health and re
This spending item is part of a $93,468 allocation. See details
National Institutes of Health 9/13/2010
CASE WESTERN RESERVE UNIVERSITY $63,000 Trans-NIH Recovery Act Research Support The Coordinating and Bioinformatics Unit (CBU) for the Animal Models of Diabetic Complications Consortium (AMDCC) and the Mouse Metabolic Phenotyping Centers (MMPC) is responsible for creating and maintaining the administrative, scientific and informatics
This spending item is part of a $1,819,749 allocation. See details
National Institutes of Health 9/28/2009
CASE WESTERN RESERVE UNIVERSITY $62,313 Trans-NIH Recovery Act Research Support The goal of this R21 application is to develop a three-dimensional (3D) model of the glomerular filtration barrier that incorporates the key cellular components, podocytes and endothelial cells, and matrix that models the glomerular basement membrane (GBM National Institutes of Health 9/21/2009
CASE WESTERN RESERVE UNIVERSITY $62,037 Trans-NIH Recovery Act Research Support The purpose of the ARRA funds awarded is to replace aging or broken equipment which is important to carry out the research projects supported by the parent grant. The goal of the parent grant is to study the structure-function relationship for a family o National Institutes of Health 1/14/2010
UNIVERSITY HOSPITALS OF CLEVELAND $61,660 ARRA - Preventing Healthcare-Associated Infections Healthcare-Associated Infections - Building and Sustaining State Programs to Prevent Healthcare-associated Infections To carry out activities to implement healthcare-associated infections reduction strategies. The purpose of the ELC cooperative agree... Show more
This spending item is part of a $373,868 allocation. See details
Centers for Disease Control and Prevention 8/28/2009
CASE WESTERN RESERVE UNIVERSITY $60,977 Trans-NIH Recovery Act Research Support Analyses of Registration Bipolar Prophylaxis Trials to Develop New Study Designs This application addresses Challenge Area (05) Comparative Effectiveness Research (CER) and specific Challenge Topic 05-MH-102 Cost Effectiveness of Mental Health Interventio
This spending item is part of a $723,678 allocation. See details
National Institutes of Health 9/24/2009
CASE WESTERN RESERVE UNIVERSITY $59,540 Trans-NIH Recovery Act Research Support There is increasing evidence that cytokines, in general, and tumor necrosis factor (TNF), in particular, may play a key role in the pathogenesis of Crohn's disease (CD), one of the known idiopathic inflammatory bowel diseases (IBD)s. The most compelling e National Institutes of Health 9/10/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $58,178 Trans-NIH Recovery Act Research Support Our primary objective is to identify specific gene variants that are related to the formation and rupture of intracranial aneurysms (IA). Our experienced collaborative and highly productive team of Familial Intracranial Aneurysm (FIA) Investigators at 27
This spending item is part of a $8,081,413 allocation. See details
National Institutes of Health 9/14/2009
CASE WESTERN RESERVE UNIVERSITY $58,178 Trans-NIH Recovery Act Research Support This project has obtained follow up photography of the fundus of CRIC patients. Analyisis of the photographs has been completed. We will be performing the statistical analysis of the results. This will allow us to investigate the relationship between pro
This spending item is part of a $1,464,614 allocation. See details
National Institutes of Health 9/30/2009
CASE WESTERN RESERVE UNIVERSITY $56,900 Trans-NIH Recovery Act Research Support The central goal of insulin replacement therapy in the treatment of diabetes mellitus (DM) is tight control of blood glucose concentrations. Clinical trials, including the landmark Diabetes Control & Complications Trial (DCCT) and follow-up Epidemiology o National Institutes of Health 1/14/2010
CASE WESTERN RESERVE UNIVERSITY $54,200 Trans-NIH Recovery Act Research Support This pilot project aims to reduce the barriers to joint review of protocols by the University Hospitals Case Medical Center Institutional Review Board (UHCMC IRB) and the Papua New Guinea Institute of Medical Research Institutional Review Board (PNG IMR I National Institutes of Health 9/25/2010
CASE WESTERN RESERVE UNIVERSITY $54,000 Trans-NIH Recovery Act Research Support Nephronophthisis (NPHP) is an important public health issue because it is the most common genetic cause of end-stage renal disease in the first three decades of life. The kidneys of patients with NPHP demonstrate scarring and cyst formation, features shar National Institutes of Health 9/22/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $53,841 Trans-NIH Recovery Act Research Support The overall aim of this project is to clarify the relationship between neuronal activity in the internal segment of the globus pallidus (GPi) and the development, phenotypic distribution and severity of dystonic movements in patients with primary generali
This spending item is part of a $514,772 allocation. See details
National Institutes of Health 9/01/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $52,845 Trans-NIH Recovery Act Research Support The goal of this study is to determine whether electrical stimulation of certain brain regions can be used to improve the gait and balance instabilities associated with ParkinsonG??s disease (PD). An animal model of PD will be used to study the effect of
This spending item is part of a $485,779 allocation. See details
National Institutes of Health 9/01/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $50,507 Trans-NIH Recovery Act Research Support Pediatric lung transplantation treats end-stage lung disease of diverse etiologies in recipients with potential for normal extrapulmonary organ function and development. However, unlike other solid organ recipients, frequencies of adverse outcomes in pedi
This spending item is part of a $158,258 allocation. See details
National Institutes of Health 9/29/2010
CASE WESTERN RESERVE UNIVERSITY $50,000 Trans-NIH Recovery Act Research Support Otitis media is one of the most common causes for visits to the emergency room and the second ranking for visits to a physician's office in the United States (>20 million visits per year), costing the nation 4- 5 billion dollars annually. By three years o
This spending item is part of a $157,265 allocation. See details
National Institutes of Health 7/17/2009
CASE WESTERN RESERVE UNIVERSITY $49,645 Trans-NIH Recovery Act Research Support This award is to assist with a project to adopt new technologies which is intended to improve the efficiency and effectiveness of the clinical trials process and reduce clinical trial costs, thereby realizing the ultimate goal of more rapid progress again National Institutes of Health 9/23/2009
CASE WESTERN RESERVE UNIVERSITY $47,100 Trans-NIH Recovery Act Research Support The 14 members of Eph kinases constitute the largest subfamily of receptor tyrosine kinases in mammalian system and bind membrane-anchored ligands called ephrins. The pivotal role of Eph/ephrin interactions in regulating development of nervous and cardiov National Institutes of Health 9/15/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $46,758 Trans-NIH Recovery Act Research Support Osteoarthritis (OA) affects 27 million Americans, many of whom have concomitant symptomatic meniscal tear. Arthroscopic partial meniscectomy (APM) is the surgical procedure used to treat these patients when conservative measures are not successful. The ef
This spending item is part of a $1,372,153 allocation. See details
National Institutes of Health 9/28/2009
CASE WESTERN RESERVE UNIVERSITY $44,296 Trans-NIH Recovery Act Research Support How insulin binds to its receptor defines a central problem in molecular endocrinology. This competing application seeks to define the active structure of insulin and points of contact between the hormone and the a subunit of the insulin receptor (IR). We National Institutes of Health 12/31/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $42,861 Trans-NIH Recovery Act Research Support Description (provided by applicant): Osteoporosis is a public health problem that affects approximately 25 million people in the United States. Regardless of the etiology, osteoporosis is characterized by an imbalance in bone remodeling, such that osteocl National Institutes of Health 5/29/2009
BALDWIN WALLACE COLLEGE $42,739 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Broad, long-term objectives: To reduce the burdens of illness and disability associated with learned fear responses that are part of post-traumatic stress disorder (PTSD) and phobias. To determine the neural mechanisms National Institutes of Health 6/05/2009
CASE WESTERN RESERVE UNIVERSITY $40,859 Trans-NIH Recovery Act Research Support OVERALL PURPOSE: TODAY is a collaborative group funded by the National Instituate of Diabetes and Digestive and Kidney Diseases (NIDDK) to conduct +B20t a clinical trial of therapies in children with type 2 diabetes (T2D). The TODAY study has enrolled 70
This spending item is part of a $1,102,576 allocation. See details
National Institutes of Health 4/12/2010
CASE WESTERN RESERVE UNIVERSITY $39,547 Trans-NIH Recovery Act Research Support A major challenge for the scientific community is to increase the participation of underrepresented minority students in biomedical research and subsequent leadership in the professoriate. For example, less than 10% of students in Case SOM biomedical PhD National Institutes of Health 9/25/2009
CASE WESTERN RESERVE UNIVERSITY $38,181 Trans-NIH Recovery Act Research Support The goal of this research is to develop and clinically implement a new method of quickly and reversibly blocking the conduction of action potentials in peripheral nerve. In our currently funded project, we have demonstrated that high frequency alternating National Institutes of Health 6/05/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $37,178 Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is a complex arrhythmia that afflicts more than 2.3 million Americans. Most prevalent in the elderly, AF is associated with a 2-fold higher risk for mortality. AF is the most potent risk factor National Institutes of Health 6/01/2009
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $31,016 Trans-NIH Recovery Act Research Support This study examines 1800 patients treated at more than 20 centers with expertise in robotic and standard prostate surgery; the patients have been evaluated for quality of life before and after surgery, and for complications, costs, and cancer control. WeG
This spending item is part of a $1,000,000 allocation. See details
National Institutes of Health 9/22/2009
CHANTEST CORPORATION $29,700 Trans-NIH Recovery Act Research Support In the most recent data supplied by the American Heart Assocation, cardiovascular disease remained the major underlying cause of death in the United States with the majority of these deaths being due to coronary heart disease and stroke. Given the high pr
This spending item is part of a $1,699,448 allocation. See details
National Institutes of Health 9/23/2009
CASE WESTERN RESERVE UNIVERSITY $29,500 Trans-NIH Recovery Act Research Support Craniofacial abnormalities represent a broad and complex class of birth defects and understanding their genetic basis is essential for their diagnosis and treatment. Despite much recent progress in understanding their etiology, many facets of their pathog National Institutes of Health 9/22/2009
CASE WESTERN RESERVE UNIVERSITY $28,260 Trans-NIH Recovery Act Research Support This program project examines the structure, biosynthesis, and roles of carbohydrates in cell-cell interaction. The proposed projects were borne-out from our strong collaborative research activities in the previous funding period. This program project i
This spending item is part of a $331,124 allocation. See details
National Institutes of Health 9/10/2009
CASE WESTERN RESERVE UNIVERSITY $24,952 Trans-NIH Recovery Act Research Support The supplement has accelerated the tempo of scientific research. This grant also support to explore our experiments to investigate involvement of innate immunity observed in age-related retinal diseases. The funds from this supplement have been used compl National Institutes of Health 7/01/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $24,288 Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (05) Comparative Effectiveness Research and specific Topic 05-CA-104* Comparative Effectiveness Research on Cancer Treatment. Effectiveness of prostate cancer treatment has been previously evaluated by Marko
This spending item is part of a $996,214 allocation. See details
National Institutes of Health 9/29/2009
CASE WESTERN RESERVE UNIVERSITY $18,896 ARRA - Scholarships for Disadvantaged Students The AARA- Scholarship for Disadvantaged Students (SDS) funding will assist our underrepresented minorities and educationally/environmentally disadvantaged students by offering them financial support. The AARA-SDS Scholarships at FPB School of Nursing wil... Show more Health Resources and Services Administration 9/03/2009
CASE WESTERN RESERVE UNIVERSITY $15,700 Trans-NIH Recovery Act Research Support This study will define mucosal virulence and mechanism of innate immune host defense against aerosolized Rift Valley fever virus, a Category A biodefense pathogen. Rift Valley Fever virus (RVFV) is designated a priority pathogen based upon its projected s National Institutes of Health 5/24/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $14,250 Trans-NIH Recovery Act Research Support The Hemodialysis Fistula Maturation Consortium (HFMC) will conduct a prospective multi-center observational cohort study investigating factors associated with the failure of arteriovenous fistulas (AVFs) to mature. The Data Coordinating Center (DCC) will
This spending item is part of a $542,808 allocation. See details
National Institutes of Health 9/21/2009
CASE WESTERN RESERVE UNIVERSITY $14,004 Trans-NIH Recovery Act Research Support This study will define mucosal virulence and mechanism of innate immune host defense against aerosolized Rift Valley fever virus, a Category A biodefense pathogen. Rift Valley Fever virus (RVFV) is designated a priority pathogen based upon its projected s National Institutes of Health 5/24/2010
CASE WESTERN RESERVE UNIVERSITY $12,500 Trans-NIH Recovery Act Research Support Chronic kidney disease (CKD) in children is a devastating illness. The prevalence of patients aged 0 ? 19 years with ESRD has grown 32% since 1990 and the mortality rate for children with ESRD receiving dialysis therapy is between 30 and 150 times that o
This spending item is part of a $525,000 allocation. See details
National Institutes of Health 9/27/2009
CASE WESTERN RESERVE UNIVERSITY $6,679 Trans-NIH Recovery Act Research Support Phosphoenolpyruvate carboxykinase (PEPCK) was discovered in 1953 by Utter and Kurahashi, yet more than 50 years later its metabolic role is still being resolved. PEPCK is a cataplerotic enzyme, which catalyzes the key reaction in hepatic and renal glucone National Institutes of Health 12/30/2009
CASE WESTERN RESERVE UNIVERSITY $5,338 Trans-NIH Recovery Act Research Support Hepatitis C virus (HCV) is the most common cause of chronic viral hepatitis in the United States. Depending on route of HIV transmission, 9%-80% of HIV infected individuals are coinfected with HCV. HIV infection appears to alter the course of HCV related National Institutes of Health 5/24/2010
CASE WESTERN RESERVE UNIVERSITY $5,052 Trans-NIH Recovery Act Research Support This one-year grant will support planning and protocol development for a 12-month, multi-center randomized trial in which older adults (ages 65 and older) with insomnia will be randomized to one of three treatment arms: 1) Zolpidem (Ambien); 2) Cognitive
This spending item is part of a $176,799 allocation. See details
National Institutes of Health 9/17/2009
CORNELL UNIVERSITY, INC $0 Trans-NIH Recovery Act Research Support This proposal presents a multidisciplinary approach to understanding a fundamental property of sensory processing: the modulation of sensory perception by acetylcholine. The proposal addresses this question in the olfactory bulb of rats, using a combinati
This spending item is part of a $100,000 allocation. See details
National Institutes of Health 8/14/2009