Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Christian Lorson
Brigham and Women's Hospital, Department: Na
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Shift Pharmaceuticals
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)
Please see uploaded document.
Optimization of a novel series of thiazolopyridines for the treatment of SMA
Spinal muscular atrophy (SMA) is a neurodegenerative disease with no known cure that causes progressive muscle weakness and primarily targets proximal muscles. We recently discovered a novel series of thiazolopyridines that: (i) promotes an increase in SMN2 protein in SMN2 luciferase reporter assay; (ii) increases SMN protein expression in patient-derived fibroblasts; (iii) acts post-transcriptionally and stabilizes the SMN protein; and (iv) demonstrates excellent plasma and brain exposure following oral administration. We propose to optimize this novel series, as activators of SMN2 protein, and we expect to identify preclinical candidates that give full lifespan and significant improvements in motor function in SMA mouse models.
Filed on July 03, 2017.
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Christian Lorson filed other conflict of interest disclosures with the NIH:
| Name | Institution | Type | Company | Disclosed Value |
|---|---|---|---|---|
| Christian Lorson | University of Missouri Columbia | Conflict of Interest | Shift Pharmaceuticals | Value cannot be readily determined |
| Christian Lorson | Indiana Univ Purdue Univ at Indianapolis | Conflict of Interest | Shift Pharmaceuticals | Value cannot be readily determined |
Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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