Dollars for Profs

Dig Into University Researchers' Outside Income and Conflicts of Interest

Published Dec. 6, 2019

This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.

Financial doc
Filing Type

Conflict of Interest

Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.

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Derek Abbott

Case Western Reserve University, Department: Pathology

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Disclosed Conflict of Interest with

Oncodesign Biotechnology

Disclosed Value
Listed Reason
Payment for services (e.g., consulting fees, honoraria, paid authorship)

NA

Listed Research Project
Innate Immune Signal Transduction Specificity in Inflammatory Disease

Faulty NOD2 activity is responsible for exacerbating inflammatory diseases. Diseases such as asthma, inflammatory bowel disease, sarcoidosis and arthritis can all be worsened by too much NOD2 activity. RIP2 is an obligate kinase in the NOD2 signaling pathway. In our prior granting period, we found FDA-approved drugs that could inhibit RIP2. This has attracted the interest of pharmaceutical companies as a number are now screening for new RIP2 inhibitors. Despite this, our knowledge of RIP2's role in the cell is murky. This grant application aims to identify RIP2 substrates, to identify biomarkers that can identify NOD2-driven inflammatory disease and predict which patient best will responds to RIP2 inhibitors, to identify additional pharmaceuticals to fine-tune the inhibition of this pathway and o determine efficacy of RIP2 inhibition in inflammatory disease.

Filed on October 20, 2016.

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Name Institution Type Company Disclosed Value
Derek Abbott Case Western Reserve University Conflict of Interest Oncodesign Biotechnology Value cannot be readily determined
If you see an error in the database or a reason we should not disclose a record, please contact us at [email protected] and we'll evaluate it on a case-by-case basis.
Sources: National Institutes of Health, public records requests filed at multiple public state universities

Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.

Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.

ProPublica obtained additional financial disclosures and conflict of interest forms that we have not yet digitized and added to the database. You can download those disclosures in the ProPublica Data Store.

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