Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Domenico Accili
Columbia University Health Sciences, Department: Internal Medicine/medicine
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Forkhead Biotherapeutics
Payment for services (e.g., consulting fees, honoraria, paid authorship)
Dr. Accili is co-founder of a new startup company called Forkhead Biotherapeutics, and holds equity in and serves on the board of directors and scientific advisory board of this non-public company. Apart from his equity, he receives nominal payment from the company ((b)(4) per quarter). Columbia has determined that the company’s aims (developing specific FOXO inhibitors as an oral treatment for diabetes) are related to the research in this R01; that the outcome of this research could affect the company or Dr. Accili’s significant financial interest in the company; and that the design, conduct, and/or reporting of this research could be affected by this financial interest.
Role of Forkhead Proteins in Insulin Action
Foxo transcription factors are key sensors of the organism's metabolic and hormonal status, and can induce changes in gene expression that account for the protean manifestations of insulin resistance, and its progression to overt diabetes. Based on a body of work developed during the past decade, we will endeavor to understand the integrated physiology of Foxo function in specific tissues, and its biochemical underpinnings. The ultimate goal of this work is to find therapeutic approaches to modify Foxo function. Indeed, whereas Foxo is an attractive biological target to reverse diabetes and metabolic diseases, it is largely intractable as a drug target. Therefore, it is hoped that by parsing its modes of action and interacting partners, new ways to modulate its function can be found.
Filed on February 15, 2018.
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Domenico Accili filed other conflict of interest disclosures with the NIH:
| Name | Institution | Type | Company | Disclosed Value |
|---|---|---|---|---|
| Domenico Accili | Columbia University Health Sciences | Conflict of Interest | Forkhead Biotherapeutics | $0 - $4,999 |
| Domenico Accili | Columbia University Health Sciences | Conflict of Interest | Forkhead Biotherapeutics | Value cannot be readily determined |
| Domenico Accili | Columbia University Health Sciences | Conflict of Interest | Forkhead Biotherapeutics | Value cannot be readily determined |
| Domenico Accili | Columbia University Health Sciences | Conflict of Interest | Forkhead Biotherapeutics | Value cannot be readily determined |
Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
ProPublica obtained additional financial disclosures and conflict of interest forms that we have not yet digitized and added to the database. You can download those disclosures in the ProPublica Data Store.