Dollars for Profs

Dig Into University Researchers' Outside Income and Conflicts of Interest

Published Dec. 6, 2019

This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.

Financial doc
Filing Type

Conflict of Interest

Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.

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Michael Brenner

Georgetown University, Department: Internal Medicine/medicine

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Disclosed Conflict of Interest with

Synovex

Disclosed Value
Listed Reason
Payment for services (e.g., consulting fees, honoraria, paid authorship)

The Co-Chairs of the Partners HealthCare Committee on Conflict of Interest (CCOI), by delegation, evaluated Dr. Brenner’s financial interest in Synovex, a private biotech company that has developed highly specific cadherin-11 antagonists for the treatment of rheumatoid arthritis and fibrotic diseases. The research under this R01 grant is aimed at determining the molecular mechanism by which cadherin-11 stimulates cell signaling and proliferation. The research will use cadherin-11 fusion proteins, RNAi and mAb. Synovex is developing an anti-cadherin-11 mAb biotherapeutic, which could be considered a “similar compound” to some of the stimulating or blocking reagents against cadherin-11 used in this R01 research. Upon review, the Co-Chairs determined that Synovex could be affected by the research in that new discoveries about cadherin-11 could affect the company’s research program. That is, this SFI was determined to be a related SFI. The Co-Chairs further determined that, given the magnitude and nature of the SFI, the interest creates an FCOI with this R01 grant; that is, the interest could directly and significantly affect the design, conduct, or reporting of the research.

Listed Research Project
Cadherin11 in cancer & rheumatoid arthritis: Common target, common therapies? (5)

Basal-like breast cancers and brain tumors of the glioblastoma type are among the poorest prognosis cancers with no effective treatments. This proposal links a molecular pathway elevated in these tumors to a similar pathway important in the inflammatory disease rheumatoid arthritis. We propose that drugs currently in use for arthritis as well as drugs repurposed to inhibit the common pathway will be useful as novel cancer therapies.

Filed on April 17, 2014.

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Name Institution Type Company Disclosed Value
Michael Brenner Georgetown University Conflict of Interest Synovex Value cannot be readily determined
Michael Brenner Brigham and Women's Hospital Conflict of Interest Adheron Therapeutics Value cannot be readily determined
Michael Brenner Brigham and Women's Hospital Conflict of Interest Adheron Therapeutics $40,000 - $59,999
If you see an error in the database or a reason we should not disclose a record, please contact us at [email protected] and we'll evaluate it on a case-by-case basis.
Sources: National Institutes of Health, public records requests filed at multiple public state universities

Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.

Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.

ProPublica obtained additional financial disclosures and conflict of interest forms that we have not yet digitized and added to the database. You can download those disclosures in the ProPublica Data Store.

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