Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Benjamin Neale
Massachusetts General Hospital, Department: Na
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Deep Genomics, Inc.
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)
Dr. Neale owns equity in Deep Genomics, Inc., a private company focused on developing machine learning methods that can find patterns in datasets and infer computer models of how cells read the genome and generate biomolecules. The company is building algorithms to model splicing. The technology provides a causal interpretation for genetic variation. The research project is focused on developing new tools and models for genotyping loss-of-function variants. One of the goals of the project is to create more accurate predictive models of the effects of genetic variants on gene expression and splicing, and of their probability of disease causation. Given the close connection between the aims of the company and the research project, the institution determined that the interests of the company could be affected by the research and that Dr. Neale’s financial interest creates a conflict of interest.
Annotation and interpretation of loss-of-function polymorphisms in human genomes
Genetic variants that cause the complete loss of function (LoF) of human protein-coding genes are known to play a major role in severe human disease, but are also highly susceptible to sequencing and annotation artifacts. We propose the development of a suite of analytical tools for the accurate identification and filtering of LoF variants, guided and validated using RNA sequencing data and databases of known severe disease mutations. We will apply these tools to large-scale human genome sequence data, generating a high-quality catalogue of LoF variants in the human population, and guiding the design of a genotyping array for further studies assessing the effects of these variants on human phenotypes and disease risk.
Filed on February 09, 2017.
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| Name | Institution | Type | Company | Disclosed Value |
|---|---|---|---|---|
| Benjamin Neale | Brigham and Women's Hospital | Conflict of Interest | Deep Genomics, Inc. | Value cannot be readily determined |
Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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