Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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David Barbie
Massachusetts General Hospital, Department: None
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Xsphera Biosciences
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)
The research aims to develop novel strategies to overcome resistance to PD-1 blockade. The research will use organotypic tumor spheroids, cultured in a 3D microfluidic system, to develop strategies to overcome resistance to the PD-1 blockade. The Company is licensing the technology that is used in the research. The results of the research could affect the financial interest of the Company. Due to the nature of the financial interest it is determined that the interest could directly and significantly affect the design, conduct and reporting of the research.
Ex Vivo Profiling of Immunotherapy Combinations Using Organotypic Tumor Spheroids
PROJECT NARRATIVE While immune checkpoint inhibitors targeting the PD-1/PD-L1 axis have show unprecedented and durable clinical responses in melanoma and other cancers, resistance remains a challenge for the majority of patients and robust biomarkers to guide treatment are lacking. This project seeks to use murine- and patient- derived organotypic tumor spheroids (MDOTS/PDOTS) cultured in a 3-dimensional microfluidic system to develop novel strategies to overcome resistance to PD-1 blockade. Thus, the MDOTS/PDOTS platform represents a potential functional precision medicine platform for the development of novel combinations and ultimately personalized immunotherapy to tailor immunotherapy treatment to individual patients.
Filed on June 18, 2019.
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Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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