Dollars for Profs

Dig Into University Researchers' Outside Income and Conflicts of Interest

Published Dec. 6, 2019

This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.

Financial doc
Filing Type

Conflict of Interest

Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.

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Jacob Hooker

Massachusetts General Hospital, Department: Na

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Disclosed Conflict of Interest with

Eikonizo Therapeutics, Inc.

Disclosed Value
Listed Reason
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)

The company is pursuing drug development for neurodegenerative diseases based on HDAC6 inhibition. The research project aims to use a PET imaging probe for HDAC-6 to assist with the development of new HDAC6-selective inhibitors for the treatment of neurological diseases. The PET imaging agent used in this study has been licensed to the company. The results of this study could therefore be of interest to the company. The Partners Committee on Outside Activities review panel evaluated the financial interest in connection with this research project and determined that, based on the close connection between the company’s interests and the research, and the type and level of the SFI, the SFI is related to the research and could directly and significantly affect the design, conduct, or reporting of the research.

Listed Research Project
Development of brain-penetrant HDAC6-selective inhibitors

Project Narrative Histone deacetylase 6 (HDAC6) have been implicated in a wide-range of neurological diseases and may offer new therapeutic opportunities. However, existing HDAC6-selective inhibitors do not penetrate the blood-brain barrier. This proposal aims to use imaging tool for directly assisting new HDAC6-selective inhibitor development, which may be used to treat several human diseases.

Filed on July 23, 2018.

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Name Institution Type Company Disclosed Value
Jacob Hooker Massachusetts General Hospital Conflict of Interest Eikonizo Therapeutics, Inc. Value cannot be readily determined
If you see an error in the database or a reason we should not disclose a record, please contact us at [email protected] and we'll evaluate it on a case-by-case basis.
Sources: National Institutes of Health, public records requests filed at multiple public state universities

Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.

Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.

ProPublica obtained additional financial disclosures and conflict of interest forms that we have not yet digitized and added to the database. You can download those disclosures in the ProPublica Data Store.

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