Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Korkut Uygun
Massachusetts General Hospital, Department: Na
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Organ Solutions, LLC
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)
Dr. Uygun is a co-founder of Organ Solutions, LLC. The company is developing perfusion systems and services for organ preservation with the goal of improving organ viability and maximizing the time to transplant. The objective of this research grant is to develop and test a dynamic, online method to assess liver transplant success in a small clinical study. The central hypothesis to be tested here is that the liver survival post-transplantation is correlated to its energy state and energy metabolism during machine perfusion. The goal is to create a dynamic, on-line liver viability score which can be used to assess the condition of the donor organs prior to transplantation surgery, ultimately reducing the guesswork involved in transplantation and consequently increasing the use of marginal donor organs reducing deaths due to graft failure. This development is anticipated to increase the pace of clinical adoption of machine perfusion preservation studies for the liver, as well as other organs. The results of this research could therefore be of interest to Organ Solutions, LLC. The institution determined that, due to the magnitude of the financial interest and the close connection between the aims of the company and the aims of the research, the financial interest could directly and significantly affect the design, conduct, or reporting of the research.
Development of a liver viability index for transplantation
PUBLIC HEALTH RELEVANCE STATEMENT There is a crisis in donor organ availability: overall there about 120,000 patients on the UNOS organ waiting list, with the number increasing by about 5% annually. Chronic liver disease and cirrhosis causes up to 60,000 deaths annually in the US many of which perish on due to lack of a transplantable liver graft. One of the issues constraining efficient use of donor grafts is the lack of quantitative metrics to determine suitability for transplantation for donors that are less than ideal, which leads to discarding a large number of potentially viable grafts. This application proposes a clinical study to identify potential biomarkers of liver viability from graft biopsies, which would provide such an objective measure for use in quality determination.
Filed on September 04, 2018.
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Korkut Uygun filed other conflict of interest disclosures with the NIH:
| Name | Institution | Type | Company | Disclosed Value |
|---|---|---|---|---|
| Mustafa Korkut Uygun | Massachusetts General Hospital | Conflict of Interest | Organ Solutions, LLC | Value cannot be readily determined |
| Korkut Mustafa Uygun | Massachusetts General Hospital | Conflict of Interest | Organ Solutions, LLC | Value cannot be readily determined |
| Mustafa Korkut Uygun | Massachusetts General Hospital | Conflict of Interest | Organ Solutions, LLC | Value cannot be readily determined |
| Mustafa Korkut Uygun | Massachusetts General Hospital | Conflict of Interest | Organ Solutions, LLC | Value cannot be readily determined |
| Korkut Uygun | Massachusetts General Hospital | Conflict of Interest | Organ Solutions, LLC | Value cannot be readily determined |
Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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