Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Raul Mostoslavsky
Massachusetts General Hospital, Department: Na
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Galilei Biosciences, Inc.
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)
Dr. Mostoslavsky is a co-founder of Galilei Biosciences, Inc. with equity in the private company. Galilei Biosciences Inc. seeks to develop activators of the mammalian SIRT6 protein. The research project tests whether SIRT6 regulates activation of metabolic and developmental genes through a novel, previously unrecognized mechanism of action, which may inform treatment against developmental diseases, metabolic diseases and cancer. The results of these research projects could therefore be of interest to the company. The Partners Committee on Outside Activities review panel evaluated the financial interest in connection with the research projects and determined that, based on the close connection between the company's interests and the research, the financial interest could directly and significantly affect the design, conduct, or reporting of the research.
The histone deacetylase SIRT6 modulates Transcriptional pausing
Project Narrative Proper regulation of gene expression represents one of the most important characteristics of appropriate cell function; each one of our cells, despite carrying all the genetic information in its DNA, expresses only a subset of specific genes in order to maintain its cell fate, differentiation stage, and growing characteristics. At the molecular level, we are still trying to understand how expression of specific genes is fine-tuned and specifically coordinated; our laboratory has identified a protein, called SIRT6, that functions as a modulator of chromatin, a highly dynamic structure that compacts DNA, in turn acting as a key regulator of embryonic development, metabolism and cancer. In this proposal, we will use biochemical and biological approaches, as well as genetically engineered cells and induced pluripotent human cells from patients with mutations in SIRT6 to test the hypothesis that SIRT6 regulates activation of metabolic and developmental genes through a novel, previously unrecognized mechanism of action.
Filed on February 01, 2019.
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Raul Mostoslavsky filed other conflict of interest disclosures with the NIH:
| Name | Institution | Type | Company | Disclosed Value |
|---|---|---|---|---|
| Raul Mostoslavsky | Massachusetts General Hospital | Conflict of Interest | Galilei Biosciences Inc. | Value cannot be readily determined |
| Raul Mostoslavsky | Massachusetts General Hospital | Conflict of Interest | Galilei Biosciences Inc. | Value cannot be readily determined |
Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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