Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Nadim Hallab
Rush University Medical Center, Department: Orthopedics
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BioEngineering Solutions, Inc.
Intellectual property rights (e.g., royalties, patents, copyrights) not from the awardee Institution
Dr. Hallab is the owner of a company named BioEngineering Solutions Inc. The company provides implant debris particles for this NIH study at no cost.
Inflammasome Danger Signaling:A Novel Target to Prevent Debris Induced Osteolysis
This project has a strong impact on the healthcare of the millions of people in the US with Total Joint Arthroplasties, particularly the >60,000 knee and hip arthroplasties that are revised each year largely due to poor performance. Implant loosening due to debris-induced aseptic osteolysis accounts for over 75% of all TJA implant revisions and is the predominant factor limiting the longevity of current total joint arthroplasties. To date thee are no pharmacologically effective therapies to mitigate the effects of implant debris to significantly prolong implant life. Thus, the goal of the proposed project is to test whether our recent discovery of inflammasome 'danger signaling' to implant debris represents a viable target for pharmacologic intervention of aseptic osteolysis. Our long term goal is to understand how to manipulate the inflammasome pathway to mitigate the untoward effects of implant debris. The objective of this proposal is to determine both the utility of this approach and how best to mitigate implant debris induced osteolysis both in vitro and in vivo.
Filed on August 28, 2014.
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Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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