Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Charles Rudin
Sloan Kettering Inst Can Research, Department: Na
Should you be removed from our database? Contact us at [email protected]. Read more below.
AbbVie Inc.
Payment for services (e.g., consulting fees, honoraria, paid authorship)
This study proposes the development of an immuno-PET diagnostic agent comprising 89Zr labeled rovalpituzumab. Aim 1 involves developing more stable thiol-clickable methylsuflone chelators for 89Zr to minimize kidney uptake. This project includes projects obtaining an antibody from AbbVie. Aim 2 will be centered on the study of the in vivo toxicology and pharmacology of 89Zr-Rova as well as the preparation and submission of an FDA Investigational New Drug application for the clinical trial. Aim 3 will be the first in-human clinical trial of 89Zr-Rova for the PET imaging of patients with small cell lung cancer concurrently enrolled on a clinical trial of the therapeutic ADC Rova-T. This 30-patient trial will be focused on the clinical safety and efficacy of 89Zr as a predictor of response to Rova-T. This project includes obtaining an antibody from AbbVie. Dr. Rudin is a paid consultant for AbbVie.
Immuno-PET imaging of high-grade neuroendocrine lung tumors using 89Zr-rovalpituzumab, a DLL3-targeting monoclonal antibody
PROJECT NARRATIVE There are no FDA-approved targets therapies of small cell lung cancer. Small cell lung cancer is one of a small number of cancers that expresses delta-like ligand 3 (DLL3) on the cell surface. Due to the exquisite cancer selectivity of DLL3 expression, the presence of this protein can itself be considered a molecular vulnerability as it allows for targeted antibody-based drug delivery and PET imaging in small cell lung cancer.
Filed on January 07, 2019.
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Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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