Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Cynthia McMurray
University of Calif Lawrenc Berkeley Lab, Department: Na
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Solano Pharmaceuticals
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)
In this grant, McMurray will test metabolism in a standard panel of ADME tests of 4 novel, but unrelated compounds with known biological properties: (CP2 (breaks up protein aggregates), HDAC inhibitors (histone deacetylase inhibitor, facilitate opening of chromatin, and OGG1inhibitors (8-oxo-G glycosylase, a DNA repair enzyme that removes damaged bases from DNA, alone or together with XJB-5-131. Dr. McMurray will measure ADME properties of an array of different compounds alone or together with XJB-5-131 in the original animal model (HD150) as a control for the other compounds.
Dr. McMurray has an SFI in Solano Pharmaceuticals, a non-publicly traded entity, of between (b)(4) and (b)(4) equity, worth less than (b)(4). The institution concluded that Dr. McMurray's financial interest in Solano Pharmaceuticals represents a Financial Conflict of Interest because the work conducted in this grant, "Chemical Fingerprinting..." may provide specific knowledge about the efficacy, or lack thereof, of the compound Solano Pharmaceuticals is developing as a chemical therapeutic. At a high level, the work done by Solano Pharmaceuticals aims to commercialize one element of the basic research performed in the 274003-Collaboration.
Solano Pharmaceutical's work is to test ADME for new chemical derivatives of XJB-5-131 with a goal of developing new derivatives of XJB-5-131 for medicinal chemistry.
Chemical Fingerprinting
There are no therapies for Huntington's Disease or methods to speed up the search for therapeutics. At-risk and affected individuals inexorably progressing toward clinical disease provide an underlying urgency, not only to find therapies for the disease, but also to develop biomarkers to predict the progress of therapeutic outcome. We propose a 'multi-hit' combination therapy to discover inhibitors of HD toxicity. Our novel discovered compounds, the two-hit strategy for therapy, and our new chemical fingerprint tool are rigorous and promising methods, and the use of all in our proposed research will fill these medical gaps.
Filed on August 04, 2014.
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Cynthia McMurray filed other conflict of interest disclosures with the NIH:
| Name | Institution | Type | Company | Disclosed Value |
|---|---|---|---|---|
| Cynthia McMurray | University of Calif Lawrenc Berkeley Lab | Conflict of Interest | Solano Pharmaceuticals | $0 - $4,999 |
Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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