Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Eugene Tkachenko
University of California, San Diego, Department: Pediatrics
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MuWells, Inc.
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)
Dr. Tkachenko is a co-founder of MuWells, Inc. and is the CEO of the company. He holds (b)(4) equity interest in the company valued at (b)(4). The project proposes to dissect the role of phospholamban in rigid matrix-induced smooth muscle hypertrophy and contraction utilizing novel human model systems including precisely bioengineered silicone substrates with primary cells and new functional platforms. The company has commercialized technology to produce cell culture devices of defined rigidity using silicone gels. Per Dr. Tkachenko, similar technology will be used to create substrates of defined rigidity for the proposed project.
Contribution of rigid matrix to allergic eosinophilic esophagitis pathogenesis
EoE is an allergic disease of increasing prevalence that requires repeated esophageal biopsy and is treated with anti-inflammatory therapy to control the complications of esophageal rigidity with stricture and food impactions caused by fibrosis and smooth muscle changes referred to as tissue remodeling. However, not all subjects respond to anti-inflammatory therapy and complications can occur despite therapy. This proposal suggests the novel hypothesis that smooth muscle and fibroblast function is regulated by a rigid matrix and aims to dissect the mechanisms by which a stiff matrix alters esophageal cell function.
Filed on July 15, 2016.
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Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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