Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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John Alverdy
University of Chicago, Department: Surgery
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Covira Surgical
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)
Covira Surgical is a startup founded by the PI of this R01, John Alverdy in order for the University of Chicago tech transfer office to license his patented tech for materials and methods for preventing and treating anastomotic leak and other microbe-mediated epithelial disorders, namely with phosphorylated high molecular weight polyethylene glycol (Pi-PEG) to Covira, which was an invention resulting from earlier cycles of this competitive renewal.
Although he is not using, studying, testing or further developing this licensed tech in the current aims of the R01, the institution has determined that the overlap in subject matter could be perceived to be a conflict of interest and that transparency through disclosure is required.
Gut pathogen virulence and its therapeutic modulation during surgical injury
Following trauma, major surgery and burn injury, there is a pressing need to understand the mechanisms leading to late onset sepsis and organ failure and its association with multi-drug resistant healthcare associated pathogens. Here we present compelling preliminary data to show that the intestinal microbiome plays a key and contributory role in maintaining and driving a recovery-direct immune response during severe injury and when it becomes depleted, as occurs during prolonged critical illness, it is replaced by a drug resistant and virulent pathobiome that subverts and suppresses immune clearance mechanisms. In this proposal we will determine the mechanisms by which maintaining the intestinal microbiome via fecal microbiota transplant prevents and even ?rescues? mice from disseminated otherwise lethal sepsis by promoting a recovery-direct immune response at the systemic level.
Filed on April 09, 2019.
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Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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