Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Suzanne Conzen
University of Chicago, Department: Internal Medicine/medicine
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Intellectual Property
Intellectual property rights (e.g., royalties, patents, copyrights) not from the awardee Institution
Dr. Conzen has intellectual property licensed through the University of Chicago to Corcept Therapeutics. The IP, titled "Glucocorticoid receptor expression as a functional biomarker for breast cancer". This IP is being employed and studied in this funded research project.
Glucocorticoid receptor-mediated survival signaling in breast cancer
Our laboratory has discovered that glucocorticoid receptor (GR) expression identifies a very poor prognosis group of patients with early-stage estrogen receptor-negative (ER-) and triple negative (ER-/PR- /HER2-) breast cancer (TNBC). Surprisingly, GR expression in ER-positive tumors is associated with a relatively good clinical outcome. Our previous pre-clinical work demonstrated that GR activation of specific target genes protects BC cells against chemotherapy-induced apoptosis. We hypothesize that ER activity antagonizes GR transcriptional function in a gene-selective manner, thereby reducing the expression of a subset of GR target genes likely to mediate chemotherapy resistance and relapse in ER- breast cancer. We propose to use ER antagonism of GR activity as a tool for identifying functionally relevant genes and pathways underlying poor prognosis TNBC. These downstream GR pathways can then be tested as novel therapeutic targets in TNBC.
Filed on August 21, 2015.
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Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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