Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Mark Gladwin
University of Pittsburgh at Pittsburgh, Department: Internal Medicine/medicine
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Globin Solutions, Inc.
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)
Dr. Gladwin's conflict arises due to his interest as an inventor of the intellectual property being evaluated/developed in bench and animal research, which the University of Pittsburgh licensed to Globin Solutions, Inc. Dr. Gladwin also holds an ownership interest in the company and serves as the Chair of the company's Board of Directors.
Antidote for inhaled CO poisoning based on mutationally engineered neuroglobin
Carbon monoxide (CO) poisoning results in an estimated 50,000 emergency department visits in the United States annually and is one of the leading causes of poisoning death. Despite the fact that it has been known since 1857 that CO produces tissue hypoxia by binding avidly to hemoglobin (Hb) and reducing oxygen carrying capacity and producing tissue hypoxia, to this date there is no specific antidotal therapy. Use of 100% normobaric or hyperbaric (3-5 atmospheres) oxygen reduces the elimination half-life from 320 minutes to 74 or 20 minutes, respectively. The practical efficacy of hyperbaric oxygen therapy has been very limited, based on the significant time delay between diagnosis in the field, transportation to a hyperbaric therapy center, and treatment within the 'dive' capsule. Furthermore, the most unstable patients with severe metabolic acidosis, and cardiac and central nervous system dysfunction require mechanical ventilation and intensive care support, not practically delivered in hyperbaric capsules. Even with this advanced therapy, persistent neurological sequelae occurred in 1/4 of subjects. In the current proposal we aim to develop a specific antidotal therapy that can be given in the field by paramedics that can remove CO from red cells, tissues, and heart and brain mitochondria within minutes, providing for a potential paradigm changing approach to the most common human poisoning.
Filed on November 17, 2017.
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Mark Gladwin filed other conflict of interest disclosures with the NIH:
| Name | Institution | Type | Company | Disclosed Value |
|---|---|---|---|---|
| Mark Gladwin | University of Pittsburgh at Pittsburgh | Conflict of Interest | National Institutes of Health | $0 - $4,999 |
| Mark Gladwin | University of Pittsburgh at Pittsburgh | Conflict of Interest | Globin Solutions, Inc. | Value cannot be readily determined |
| Mark Gladwin | University of Pittsburgh at Pittsburgh | Conflict of Interest | Globin Solutions, Inc. | Value cannot be readily determined |
| Mark Gladwin | University of Pittsburgh at Pittsburgh | Conflict of Interest | Globin Solutions, Inc. | Value cannot be readily determined |
Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
ProPublica obtained additional financial disclosures and conflict of interest forms that we have not yet digitized and added to the database. You can download those disclosures in the ProPublica Data Store.