Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Claudio Soto
University of Texas Hlth Sci Ctr Houston, Department: Neurology
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Amprion, Inc.
Payment for services (e.g., consulting fees, honoraria, paid authorship)
Dr. Soto has equity in Amprion, Inc., which is a private, for-profit diagnostics company focused on highly sensitive detection and prognosis of diseases caused by misfolded proteins. Dr. Soto also receives compensation from Amprion, Inc. for consulting services and travel reimbursement. The research will utilize the related technology owned by Amprion, Inc. to amplify and detect amyloid-beta misfolded protein aggregates in biological fluids of patients affected by Alzheimer’s disease.
Isolation, characterization and pathogenic role of self-propagating conformational amyloid-beta strains
NARRATIVE Alzheimer's disease (AD) is the most common form of dementia in the late-life, for which there is no cure, or efficient treatment. The etiology of the disease is unknown but strong evidence suggest a major role for the misfolding, aggregation, accumulation and brain spreading of A? aggregates. A? deposits are highly heterogeneous, appearing in the form of mature dense-core plaques, early immature plaques, diffuse deposits, cerebral amyloid angiopathy, inert deposits and intra-cellular aggregates. Several lines of evidence have shown that A? can adopt different self-perpetuating conformational strains, which may explain the heterogeneity observed in the patients' brains. The main goal of this project is to comprehensively study the phenomenon of A? conformational strains using various biochemical, biological and structural techniques, develop new tools to isolate and discriminate between strains and identify their presence and pathogenic role in patients' samples. These studies may contribute to understand the molecular basis of AD and provide novel strategies for diagnosis and treatment.
Filed on October 22, 2018.
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Claudio Soto filed other conflict of interest disclosures with the NIH:
| Name | Institution | Type | Company | Disclosed Value |
|---|---|---|---|---|
| Claudio Soto | University of Texas Hlth Sci Ctr Houston | Conflict of Interest | Amprion, Inc. | $20,000 - $39,999 |
| Claudio Soto | University of Texas Hlth Sci Ctr Houston | Conflict of Interest | Amprion, Inc. | $0 - $4,999 |
| Claudio Soto | University of Texas Hlth Sci Ctr Houston | Conflict of Interest | Amprion, Inc. | $0 - $4,999 |
| Claudio Soto | University of Texas Hlth Sci Ctr Houston | Conflict of Interest | Amprion, Inc. | Value cannot be readily determined |
| Claudio Soto | University of Texas Hlth Sci Ctr Houston | Conflict of Interest | Amprion, Inc. | Value cannot be readily determined |
Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
ProPublica obtained additional financial disclosures and conflict of interest forms that we have not yet digitized and added to the database. You can download those disclosures in the ProPublica Data Store.