Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Qingyun Liu
University of Texas Hlth Sci Ctr Houston, Department: Other Basic Sciences
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Wntrix, Inc.
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)
Dr. Liu is a co-founder and holds equity in Wntrix, Inc. The company is a private, for-profit company that will develop novel antibody-based cancer therapeutics for the treatment of major types of solid tumors such as liver, lung and colon cancer. The goal of the NIH project is to study the biochemical and cellular mechanism of how LGR4 and LGR5 regulate the Wnt signaling pathway, studying the pathway and basic mechanism of regulation. The company will attempt to discover an antibody that finds and disrupts the pathway, to develop a therapeutic agent that can be commercialized. The institution felt that the potential for the appearance of a financial conflict of interest in the NIH research exists.
Function and mechanism of LGR4 and LGR5 in modulation of Wnt signaling
Stem cells are critical to the maintenance and repair of normal tissues. Understanding of the maintenance and growth of stem cells is critical to the development of stem cell-based therapeutics for the treatment of degenerative diseases. LGR4 and LGR5 are two genes with essential function in the stem cells of intestine by functioning as receptors for stem cell growth factors. However, little is known about the signaling mechanisms of LG4 and LGR5 in stem cells. The goal of this project is to identify and characterize signal transducers and mechanism of LGR4 and LGR5 that enable them to perform their essential function in stem cells. The research will lead to a better understanding of the biology of adult stem cells and may provide important knowledge to the development of therapeutics for regenerative medicine.
Filed on March 02, 2015.
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Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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