Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Eric Arts
University of Western Ontario, Department: Na
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N/A - Please see documents attached below.
Other : N/A - No FCOI
N/A - No FCOI
Impact of HIV-1 fitness on disease progression
HIV is not a single virus infecting 33 million people worldwide but rather, 33 million different viruses infecting 33 million people. This virus has evolved at an alarming rate since entering the human population near the turn of 19th century. Aside from being different in its genetic code, different HIV-1 subtypes and recombinant forms may not have evolved to the same virulence; that is some types of HIV-1 may cause a faster progression to AIDS than others. In this grant proposal, we now suggest that 'stage is set' for the aggressive nature of disease based on what type of HIV-1 strain found at the earliest time within the blood of the newly infected person. In addition, by comparing the rate of disease progression in Ugandan and Zimbabwean over the past ten years, we show that infection with HIV-1 subtype C (predominant in the world) causes slower disease as compared to HIV-1 subtype A and D infections (also highly prevalent in Africa). Although this difference requires years of study in patients, we now know that the HIV-1 subtype C strains in laboratory experiments is much less fit than the HIV-1 subtype A and D strains. These studies suggest we may have a surrogate laboratory assay that predicts a 10 year disease course and also provides a time estimate as to when to begin treatment.
Filed on July 24, 2015.
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Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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