Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Craig T. January
University of Wisconsin Madison, Department: Internal Medicine/medicine
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Cellular Dynamics Internationa
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)
How the interest relates to the PHS-funded research: An outside activity has a nexus with an individual's research activities if the outside activity arises from, relies upon or is related to the academic expertise that qualifies that individual to participate in federally funded research or human subjects research.
Basis for determination of conflict: The Institution has reasonably determined that the significant financial interest could directly and significantly affect the design, conduct, or reporting of the PHS-funded research and so requires management.
Caveolae and Cardiac Repolarization
Cardiac arrhythmias can be life threatening and are manifestations of many different forms of heart disease. Understanding the cellular mechanisms that regulate the electrical signals in the heart will provide new insights for therapy and prevention of cardiac arrhythmias. DESCRIPTION (provided by applicant): Changes in the repolarization properties of cardiac muscle frequently underlie the increased susceptibility to ventricular arrhythmias in a variety of heart diseases, but the control of cardiac repolarization is incompletely understood. Abnormalities of repolarization resulting in action potential duration prolongation or shortening can be pro-arrhythmic. Multiple different ion channels in cardiomyocytes impact action potential repolarization, and the diversity of ion channels and regulatory pathways involved in repolarization is highlighted by the association of at least 13 distinct genes with the inherited long QT syndrome which is due to delayed repolarization. For example, mutations in the caveolin-3 gene (CAV3) have been implicated as one cause of the inherited Long QT syndrome (LQTS). Cav-3 is an essential scaffolding protein required for the formation of specialized membrane microdomains in cells referred to as caveolae which are home to multiple signaling molecules and ion channel proteins. Preliminary data presented in this application show that genetic ablation of caveolin-3 in the mouse heart dramatically prolongs cardiac repolarization. The proposed research will test the hypothesis that cardiac caveolae provide integrated regulation of cardiac repolarization by controlling the density and functional properties of specifc ion channels. Using both genetically engineered mouse models with cardiac-specific regulation of Cav-3 expression as well as human iPS cell-cardiomyocyte models, the proposal will examine the role of caveolae in the regulation of cardiac repolarization in three specific aims: 1) Determine the impact of changes in the abundance of Cav-3 in cardiomyocytes on the density of caveolae and on cardiac repolarization; 2) Evaluate the impact of changes in Cav-3 abundance and LQTS-associated Cav-3 mutations on the density and biophysical properties of voltage-gated potassium currents; and 3) Determine how wild type Cav-3 and LQTS-associated mutations of Cav-3 regulate the density and properties of ICa,L. These studies will provide mechanistic new insights into the control of cardiac repolarization and abnormalities in disease which can result in arrhythmias.
Filed on August 09, 2013.
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Other search results for: “Craig T. January”
Name | Institution | Type | Company | Disclosed Value |
---|---|---|---|---|
Craig T. January | University of Wisconsin Madison | Conflict of Interest | Cellular Dynamics Internationa | $60,000 - $79,999 |
Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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