Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Lonny Levin
Weill Medical Coll of Cornell Univ, Department: Pharmacology
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CEP Biotech, Inc.
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)
Monoclonal antibodies (mAbs) against soluble adenylyl cyclase (sAC), is a protein that is found in the cytoplasm, at the mitochondria, at the centriole and within the nucleus. This includes four different antibodies, each of which recognizes the sAC protein at a distinct epitope and are useful in a variety of research applications, including immunoprecipitation (IP), immunofluorescence (IF), immnuocytochemistry (ICC), immnuohistochemistry (IHC), and/or affinity purification (AP). Each of them cross-reacts with sAC of human, mouse and rat origins. These mAbs have been shown to be useful in helping to distinguish benign melanocytes (as in moles and birthmarks) from cancerous melanocytes (as in melanoma) in biopsy samples. Drs. Lonny Levin and Jochen Buck have patents on specific uses of the antibodies. Cornell University has licensed this their company CEP Biotech, which they are co-founders and co-owners.
The studies associated with this grant will be testing the central hypothesis that sperm actively up-regulate their metabolism during capacitation to generate sufficient energy for motility and other capacitation associated processes necessary for fertilization. It will also be testing the hypothesis that sAC acts as a metabolic sensor in sperm which regulates the metabolic changes induced by capacitation, and regulates energy production during sustained sperm motility.
The work proposed has the potential to increase the interest in sAC studies which could lead to increased demand for the antibody sold by CEP Biotech Inc. (i.e. for research use).
Crosstalk between metabolic and signaling pathways involved in sperm capacitation
Project Narrative (no more than 3 sentences) To fertilize an egg, sperm must undergo a post-ejaculation maturation process and swim long distances. Both of these processes consume a lot of energy. In this application, we propose to identify how sperm gain sufficient energy to complete their maturation and reach the egg.
Filed on October 02, 2017.
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Lonny Levin filed other conflict of interest disclosures with the NIH:
| Name | Institution | Type | Company | Disclosed Value |
|---|---|---|---|---|
| Lonny Levin | Weill Medical Coll of Cornell Univ | Conflict of Interest | Cutting Edge Pattern (CEP) Biotech | $0 - $4,999 |
| Lonny Levin | Weill Medical Coll of Cornell Univ | Conflict of Interest | CEP Biotech | $0 - $4,999 |
| Lonny Levin | Weill Medical Coll of Cornell Univ | Conflict of Interest | CEP Biotech | Value cannot be readily determined |
| Lonny Levin | Weill Medical Coll of Cornell Univ | Conflict of Interest | Cutting Edge Pattern (CEP) Biotech | Value cannot be readily determined |
Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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