Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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W. Mark Saltzman
Yale University, Department: Radiation Diagnostic/oncology
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TruCode Gene Repair, Inc.
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)
Please see the attached document for the required information.
PNA Nanoparticles for Gene Editing In Vivo
This application will develop novel chemically modified peptide nucleic acids (PNAs) for highly effective and non-toxic gene editing, delivered in vivo by polymer nanoparticles. PNAs are synthetic pieces of DNA that can bind to the chromosomes of cells in a targeted manner and stimulate recombination of the target site with single-stranded donor DNAs to produce gene editing, with extremely low off target effects compared to other approaches. We will test the novel PNAs for correction of a thalassemia-associated mutation in the ?-globin gene in mice using nanoparticle-mediated delivery via simple intravenous (IV) administration, a minimally invasive approach that could lead to a clinically applicable method for therapeutic gene editing.
Filed on July 22, 2019.
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W. Mark Saltzman filed other conflict of interest disclosures with the NIH:
| Name | Institution | Type | Company | Disclosed Value |
|---|---|---|---|---|
| W. Mark Saltzman | Yale University | Conflict of Interest | Tru Code (formerly PNA Innovations) | $20,000 - $39,999 |
| W. Mark Saltzman | Yale University | Conflict of Interest | TruCode Gene Repair, Inc. | $20,000 - $39,999 |
| W. Mark Saltzman | Yale University | Conflict of Interest | Tru Code (formerly PNA Innovations) | Value cannot be readily determined |
Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
ProPublica obtained additional financial disclosures and conflict of interest forms that we have not yet digitized and added to the database. You can download those disclosures in the ProPublica Data Store.