| PART III, LINE 1: |
THE STOWERS INSTITUTE FOR MEDICAL RESEARCH ("SIMR") PERFORMS MEDICAL RESEARCH IN THE PUBLIC INTEREST WITH THE GOAL OF EXPANDING THE UNDERSTANDING OF FUNDAMENTAL PROCESSES IN LIVING CELLS AND IMPROVING LIFE'S QUALITY THROUGH INNOVATIVE APPROACHES TO THE CAUSES, TREATMENT, AND PREVENTION OF DISEASE. PART III, LINE 4: SIMR'S ACCOMPLISHMENTS ARE DESCRIBED AT THE END OF SCHEDULE O. PART VI, LINE 2: VIRGINIA G. STOWERS, JONATHAN THOMAS, RICHARD W. BROWN, DAVID A. WELTE, DAVID M. CHAO, ALBERZINE FREEMAN, AND ALEJANDRO SANCHEZ ALVARADO, ALL DIRECTORS OF SIMR, HAVE A BUSINESS RELATIONSHIP. JONATHAN THOMAS, RICHARD W. BROWN, DAVID A. WELTE, DAVID M. CHAO, RODERICK L. STURGEON, AND ALBERZINE FREEMAN, DIRECTORS OF SIMR, AND BRENT KREIDER, OFFICER OF SIMR, HAVE A BUSINESS RELATIONSHIP. DAVID A. WELTE, RICHARD W. BROWN, AND RODERICK L. STURGEON, DIRECTORS OF SIMR, AND BRENT KREIDER, OFFICER OF SIMR, HAVE A BUSINESS RELATIONSHIP. PART VI, LINE 11B: THE DATA AND INFORMATION NECESSARY TO PREPARE SIMR'S FORM 990 WAS COMPILED BY SIMR'S ACCOUNTING DEPARTMENT AND THEN REVIEWED BY THE INSTITUTE'S S TAX ATTORNEY AT BRYAN CAVE LEIGHTON PAISNER, LLP. PRICEWATERHOUSECOOPERS ("PWC"), THE INSTITUTE'S EXTERNAL TAX PREPARERS, USED THIS INFORMATION TO PREPARE THE FORM 990. THE COMPLETED FORM 990, INCLUDING REQUIRED SCHEDULES, IS REVIEWED BY THE OFFICERS OF SIMR BEFORE IT IS FILED WITH THE IRS. AFTER THE PREPARATION AND REVIEW PROCESS DESCRIBED ABOVE, THE FORM 990, INCLUDING REQUIRED SCHEDULES, IS PROVIDED TO EACH VOTING MEMBER OF THE ORGANIZATION'S BOARD BEFORE IT IS FILED WITH THE IRS. PART VI, LINE 12C: SIMR HAS ADOPTED A "CONFLICTS OF INTEREST AND DIRECTOR INDEPENDENCE POLICY". EACH DIRECTOR, OFFICER, AND ALL OTHER PERSONS IN A POSITION TO EXERCISE SUBSTANTIAL INFLUENCE OVER DECISIONS OF SIMR ARE REQUIRED TO ANNUALLY COMPLETE AND SIGN A DISCLOSURE STATEMENT THAT IS PART OF THE POLICY. A COVERED PERSON MUST ALSO DISCLOSE THE EXISTENCE OF A POTENTIAL CONFLICT AND ALL MATERIAL FACTS TO THE GOVERNING BOARD AS SOON AS THE PERSON HAS KNOWLEDGE THAT A POTENTIAL CONFLICT MIGHT EXIST. SIMR CONDUCTS PERIODIC AND ADHOC REVIEWS OF TRANSACTIONS AND AGREEMENTS TO ENSURE THAT IT ENGAGES ONLY IN ACTIVITIES THAT ARE CONSISTENT WITH ITS TAX-EXEMPT PURPOSE. FORM 990, PART VI, LINE 15A: THE COMPENSATION FOR DAVID CHAO, THE PRESIDENT AND CEO OF SIMR, WAS ESTABLISHED PURSUANT TO THE PROCEDURES OF TREAS. REG. SECTION 53.4958- 6, INCLUDING (1) REVIEW AND APPROVAL BY SIMR'S COMPENSATION COMMITTEE COMPRISED OF INDEPENDENT PERSONS, (2) RELYING ON COMPARABILITY DATA, INCLUDING DATA PREPARED BY A NATIONALLY KNOWN COMPENSATION CONSULTANT REGARDING COMPARABLE SALARY AND BENEFITS FOR SIMILARLY QUALIFIED PERSONS IN FUNCTIONALLY COMPARABLE POSITIONS AT SIMILARLY SITUATED ORGANIZATIONS, AND (3) CONTEMPORANEOUS DOCUMENTATION AND RECORD KEEPING OF THE DELIBERATION AND DECISIONS REGARDING THE COMPENSATION ARRANGEMENT. THIS PROCESS WAS LAST UNDERTAKEN IN 2019. PART VI, LINE 19: SIMR'S GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, AND FINANCIAL STATEMENTS ARE AVAILABLE UPON REQUEST. PART VII, SECTION A, COLUMN B: DAVID M. CHAO, OFFICER OF SIMR, AND R. SCOTT HAWLEY, EMPLOYEE OF SIMR, ALSO PERFORM SUPPORT SERVICES FOR ONE OR MORE OF THE RELATED ORGANIZATIONS DISCLOSED IN SCHEDULE R. THESE SERVICES ARE PERFORMED IN THEIR ROLE AS SIMR EMPLOYEES AND SIMR IS REIMBURSED BY THE RELATED ORGANIZATIONS. PART VII, SECTION B: SIMR RECEIVES INVESTMENT MANAGEMENT SERVICES FROM AMERICAN CENTURY INVESTMENTS ("ACI"). ACI IS A WHOLLY OWNED SUBSIDIARY OF AMERICAN CENTURY COMPANIES, INC. ("ACCI"). IN SELECTING ACI TO MANAGE ITS LIQUID INVESTMENTS, SIMR NOT ONLY CHOSE A HIGH QUALITY MUTUAL FUND COMPANY WITH AN OUTSTANDING TRACK RECORD, BUT ALSO PLACED ITS LIQUID INVESTMENTS IN A COMPANY IN WHICH IT OWNS STOCK AND RECEIVES DIVIDENDS. SIMR PAYS ACI THE SAME ADMINISTRATIVE FEES FOR THESE SERVICES AS ANY ARMS-LENGTH INVESTOR.THOSE INVESTMENT FEES FOR A SHARED INVESTMENT POOL ARE PAID BY ITS SUPPORTING ORGANIZATION, STOWERS RESOURCE MANAGEMENT. PART XI, LINE 9: OTHER CHANGES IN NET ASSETS INCLUDE THE FOLLOWING: CHANGE IN ANNUITY RECEIVABLE, NET ($234,502) |
| PART III, LINE 4A |
2019 PROGRAM SERVICE ACCOMPLISHMENTS THE STOWERS INSTITUTE FOR MEDICAL RESEARCH ("SIMR") IS A PRIVATE, NONPROFIT MEDICAL RESEARCH ORGANIZATION. SIMR WAS FOUNDED IN 1994 BY JIM AND VIRGINIA STOWERS, WHO EACH SURVIVED A BOUT WITH CANCER AND SUBSEQUENTLY DEDICATED THEIR FORTUNE TO SUPPORTING BASIC RESEARCH IN CELL AND MOLECULAR BIOLOGY THAT WILL PROVIDE LONG-TERM SOLUTIONS TO HUMAN DISEASES. SIMR CONDUCTS BASIC BIOMEDICAL RESEARCH IN THE PUBLIC INTEREST THAT WILL ULTIMATELY PROVIDE A GREATER UNDERSTANDING OF THE GENES AND PROTEINS THAT CONTROL HOW CELLS IN OUR BODIES MULTIPLY, FORM TISSUES, AND DIE. STUDYING THE BASIC BIOLOGY OF CELLS ENABLES SCIENTISTS TO DISCOVER HOW GENES CAUSE MANY DISEASES, INCLUDING CANCER, BIRTH DEFECTS, AND DEMENTIA. HISTORY HAS SHOWN THAT BASIC MEDICAL RESEARCH IS OFTEN A KEY FIRST STEP IN THE DEVELOPMENT OF NEW TREATMENTS, CURES, AND PREVENTIONS FOR MANY HUMAN DISEASES. 2019 NOTABLE RESEARCH RESULTS IN 2019, SIMR RESEARCH TEAMS MADE DISCOVERIES MERITING PUBLICATION IN LEADING PEER-REVIEWED SCIENTIFIC JOURNALS - 74 ORIGINAL RESEARCH PAPERS IN ALL. SIMR RESEARCH TEAMS ALSO PRODUCED 34 OTHER PUBLICATIONS INCLUDING REVIEWS, COMMENTARIES, BOOK CHAPTERS, AND BOOKS. SOME OF THE HIGHLIGHTS AMONG THESE PAPERS AND OTHER ADVANCES INVOLVING STOWERS RESEARCH INCLUDE THE FOLLOWING: THE KRUMLAUF LAB HELPED LAY THE GROUNDWORK FOR A NEW APPROACH TO TREATING OSTEOPOROSIS WITH AN UNEXPECTED DISCOVERY MADE NEARLY TWO DECADES AGO. AFTER UNCOVERING A MECHANISM THAT CONTROLS BONE GROWTH, THEIR WORK WAS PATENTED AND THE INTELLECTUAL PROPERTY LICENSED TO AMGEN IN 2005. AMGEN USED THAT FINDING AS WELL AS OTHERS' RESEARCH ABOUT BONE GROWTH TO DEVELOP A NEW DRUG, ROMOSOZUMAB. TWO PHASE 3 CLINICAL TRIALS SHOWED A SIGNIFICANT REDUCTION OF FRACTURES. THE DRUG ALSO INCREASED BONE DENSITY IN THE SPINES OF STUDY PARTICIPANTS BY AROUND 15%. ROMOSOZUMAB, THE FIRST NEW DRUG AIDED BY RESEARCH FROM SIMR, WAS APPROVED BY THE US FOOD AND DRUG ADMINISTRATION IN JANUARY 2019. THE LI LAB PUBLISHED A STUDY DESCRIBING HOW BLOOD-FORMING ADULT STEM CELLS REPOPULATE AFTER CHEMOTHERAPY. THESE CELLS, CALLED "RESERVE" HEMATOPOIETIC STEM CELLS, RESIDE IN BONE MARROW. THEY ARE RESPONSIBLE FOR REGENERATING THE BODY'S BLOOD SUPPLY, REPOPULATING AFTER CHEMOTHERAPY OR INJURY DEPLETES THEIR NUMBERS. THE FINDINGS MAY OPEN NEW AVENUES FOR TREATING BLOOD DISEASES LIKE LEUKEMIA AND AUTOIMMUNE DISORDERS. THE STUDY WAS PUBLISHED ONLINE JANUARY 15, 2019, IN CELL REPORTS. THE WASHBURN LAB CREATED A TOPOLOGICAL SCORING (TOPS) ALGORITHM, WHICH ALLOWS SCIENTISTS TO LOOK AT BIG SETS OF DATA IN NEW WAYS. THIS HELPS SCIENTISTS UNCOVER MORE DETAILS ABOUT HOW PROTEINS INTERACT AND UNDERSTAND HOW CERTAIN ACTIVITIES ON THE CELLULAR LEVEL HAPPEN. THE REPORT WAS PUBLISHED IN THE MARCH 8, 2019, ISSUE OF NATURE COMMUNICATIONS. THE BAZZINI LAB SHOWED THAT IN HUMAN CELL LINES, RIBOSOMES PLAY AN ACTIVE ROLE IN REGULATING MRNAS - THE MESSAGES THAT RIBOSOMES READ TO MAKE PROTEINS. THE STUDY ALSO PROVIDES EVIDENCE FOR ANOTHER LAYER OF INFORMATION WITHIN THE MESSAGES THAT CAN AFFECT MRNA LEVELS AND STABILITY. UNDERSTANDING THE REGULATORY FUNCTION OF RIBOSOMES IN MODULATING GENE EXPRESSION IN HUMAN CELLS CAN PROVIDE INSIGHT ABOUT CAUSES OF GENE MISREGULATION, WHICH CAN SOMETIMES LEAD TO HUMAN DISEASES. THE FINDINGS WERE PUBLISHED ONLINE APRIL 23, 2019, IN ELIFE. THE GERTON LAB UNCOVERED AN ANSWER TO A CENTURIES-OLD QUESTION OF HOW CONNECTIONS BETWEEN PARTICULAR HUMAN CHROMOSOMES MIGHT BE BUILT. THESE INTER-CHROMOSOMAL CONNECTIONS ARE COMPOSED OF RIBOSOMAL DNA WITH A SHARED SEQUENCE. THE FINDINGS SUGGEST THAT THE CONNECTIONS ARE CONTROLLED BY THE PROXIMITY OF THE CHROMOSOMES IN THREE-DIMENSIONAL SPACE AND THEIR TRANSCRIPTION, WHICH TOGETHER ALLOW CHROMOSOMES TO BUMP INTO EACH OTHER AND BECOME INTERLOCKED. THE FINDINGS COULD PROVIDE CLUES ABOUT THE ORIGINS OF CHROMOSOMAL FUSIONS ASSOCIATED WITH INFERTILITY AND DEVELOPMENTAL DISORDERS IN HUMANS. THE ARTICLE WAS PUBLISHED JULY 23, 2019, IN THE JOURNAL OF CELL BIOLOGY. THE GIBSON LAB PUBLISHED RESEARCH HIGHLIGHTING THE IMPORTANCE OF UNIFORM CELL SIZE IN MAINTAINING THE ARCHITECTURE OF EPITHELIAL SHEETS. ABNORMALLY SMALL EPITHELIAL CELLS CAN DISSOCIATE FROM EACH OTHER AND DISPERSE AMONG NORMAL CELLS. A SERIES OF EXPERIMENTS SHOWED THAT ABNORMAL SMALL-CELL DISPERSAL RESULTS FROM GEOMETRIC EFFECTS OF CELL SIZE VARIATION ON EPITHELIAL PACKING. THESE FINDINGS MAY FURTHER THE UNDERSTANDING OF HUMAN DISEASE PROGRESSION. THE STUDY WAS PUBLISHED ONLINE SEPTEMBER 5, 2019, IN DEVELOPMENTAL CELL. THE HAWLEY LAB DISCOVERED MORE DETAILS ABOUT HOW THE SYNAPTONEMAL COMPLEX IN MEIOSIS PERFORMS ITS JOB. THIS LARGE PROTEIN COMPLEX IS A CRITICAL PLAYER IN THE SEGREGATION OF CHROMOSOMES DURING MEIOSIS. EXPERIMENTS INDICATED THAT THE X CHROMOSOME OF THE FRUIT FLY IS SENSITIVE TO DEFECTS IN THE STRUCTURE OF THE SYNAPTONEMAL COMPLEX, WITH EFFECTS VARYING DEPENDING PARTLY ON THE STAGE OF MEIOSIS. THE RESEARCH MAY HELP FURTHER UNDERSTANDING OF THE CAUSES OF HUMAN MISCARRIAGE. THE WORK WAS PUBLISHED ONLINE SEPTEMBER 30, 2019, IN THE PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. THE WASHBURN LAB UNCOVERED NEW DETAILS ABOUT SEVERAL PROTEINS IMPLICATED IN CANCER. THE RESEARCH FOCUSED ON THE SMAD4, A TRANSCRIPTION FACTOR THAT NORMALLY SUPPRESSES TUMOR GROWTH, AND A PROTEIN CALLED BRK THAT BINDS TO SMAD4 AND LEADS TO ITS BREAKDOWN. THEIR WORK EXAMINED THE PROTEINS IN HUMAN CELL LINES INCLUDING BREAST CELL CANCER TYPES AND SUGGESTED THAT TREATMENTS TARGETING BRK, WHICH IS PRESENT IN MORE THAN 85 PERCENT OF BREAST CANCER TUMORS, COULD HELP REDUCE OR STOP TUMOR GROWTH. THE STUDY WAS PUBLISHED ONLINE OCTOBER 23, 2019, IN SCIENCE ADVANCES. COMPREHENSIVE LISTS OF 2019 ORIGINAL RESEARCH PAPERS, REVIEWS, COMMENTARIES, CHAPTERS, AND BOOKS ORIGINAL RESEARCH PAPERS |
| 1. EFFICIENT DEPLETION OF RIBOSOMAL RNA FOR SEQUENCING IN |
PLANARIANS. KIM IV,ROSS EJ, DIETRICH S, DORING K, SNCHEZ ALVARADO A, KUHN CD. BMC GENOMICS.2019;20:909. DOI: 10.1186/S12864-019-6292-Y. 2. BRK PHOSPHORYLATES SMAD4 FOR PROTEASOMAL DEGRADATION AND INHIBITS TUMOR SUPPRESSOR FRK TO CONTROL SNAIL, SLUG AND METASTATIC POTENTIAL. MIAH S, BANKS CAS,OGUNBOLUDE Y, BAGU ET, BERG JM, SARAF A, TETTEY TT, HATTEM G, DAYEBGADOH G, KEMPF CG, SARDIU M, NAPPER S, FLORENS L, LUKONG KE, WASHBURN MP. SCI ADV.2019;5:EAAW3113. DOI: 3110.1126/SCIADV.AAW3113. 3. PLANARIANS RECRUIT PIRNAS FOR MRNA TURNOVER IN ADULT STEM CELLS. KIM IV, DUNCAN EM, ROSS EJ, GORBOVYTSKA V, NOWOTARSKI SH, ELLIOTT SA, SNCHEZ ALVARADO A, KUHN CD.GENES DEV. 2019;33:1575-1590. 4. AN ADULT BRAIN ATLAS REVEALS BROAD NEUROANATOMICAL CHANGES IN INDEPENDENTLY EVOLVED POPULATIONS OF MEXICAN CAVEFISH. LOOMIS C, PEUSS R, JAGGARD JB, WANG Y,MCKINNEY S, RAFTOPOULOS A, RAFTOPOULOS S, WHU D, GREEN MR, MCGAUGH SE, ROHNER NE, KEENE AC, DUBOUE ER. FRONT NEUROANAT. 2019;13:88. DOI: 10.3389/FNANA.2019.00088. 5. X CHROMOSOME AND AUTOSOMAL RECOMBINATION ARE DIFFERENTIALLY SENSITIVE TO DISRUPTIONS IN SC MAINTENANCE. BILLMYRE KK, CAHOON CK, HEENAN GM, WESLEY ER, YU Z,UNRUH JR, TAKEO S, HAWLEY RS. PROC NATL ACAD SCI U S A. 2019;116:21641-21650. 6. AN ATLAS OF TRANSCRIPTION FACTORS EXPRESSED IN MALE PUPAL TERMINALIA OF DROSOPHILA MELANOGASTER. VINCENT BJ, RICE GR, WONG GM, GLASSFORD WJ, DOWNS KI, SHASTAY JL, CHARLES-OBI K, NATARAJAN M, GOGOL M, ZEITLINGER J, REBEIZ M. G3(BETHESDA). 2019. DOI: 10.1534/G3.119.400788. 7. DEFINING THE EXPRESSION OF PIRNA AND TRANSPOSABLE ELEMENTS IN DROSOPHILA OVARIAN GERMLINE STEM CELLS AND SOMATIC SUPPORT CELLS. STORY B, MA X, ISHIHARA K, LI H, HALL K, PEAK A, ANOJA P, PARK J, HAUG J, BLANCHETTE M, XIE T. LIFE SCI ALLIANCE.2019;2:E201800211. DOI: 10.26508/LSA.XXX-XX-XXXX. 8. EVOLUTIONARY ORIGIN AND NOMENCLATURE OF VERTEBRATE WNT11-FAMILY GENES.POSTLETHWAIT JH, NAVAJAS ACEDO J, PIOTROWSKI T. ZEBRAFISH. 2019;16:469-476. 9. PERTURBED CRANIAL NEURAL CREST CELL DEVELOPMENT IN ASSOCIATION WITH REDUCED SONIC HEDGEHOG SIGNALING UNDERLIES THE PATHOGENESIS OF RETINOIC-ACID-INDUCED CLEFT PALATE. WANG Q, KUROSAKA H, KIKUCHI M, NAKAYA A, TRAINOR PA, YAMASHIRO T. DIS MODEL MECH. 2019;12. 10. EXPERIMENTAL EVOLUTION OF IMMUNOLOGICAL SPECIFICITY. FERRO K, PEUSS R, YANG W,ROSENSTIEL P, SCHULENBURG H, KURTZ J. [PUBLISHED AHEAD OF PRINT SEPTEMBER 23 2019].PNAS. 2019. 11. PROTRUSION MEMBRANE PEARLING EMERGES DURING THREE-DIMENSIONAL CELL DIVISION.CABALLERO D, MENDES PINTO I, RUBINSTEIN B, SAMITIER J. PHYS BIOL. 2019. 12. DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (DNA-PKCS) CONTRIBUTES TO INCORPORATION OF HISTONE VARIANT H2A.Z INTO NUCLEOSOMES. WANG LY, HE YX, LI M,DING J, SUI Y, CONAWAY JW, CONAWAY RC, WANG F, JIN J, CAI Y. PROTEIN CELL. 2019;10:694-699. 13. IDENTIFICATION OF A NUCLEAR LOCALIZATION SIGNAL AND IMPORTIN BETA MEMBERS MEDIATING NUAK1 NUCLEAR IMPORT INHIBITED BY OXIDATIVE STRESS. PALMA M, RIFFO EN,SUGANUMA T, WASHBURN MP, WORKMAN JL, PINCHEIRA R, CASTRO AF. J CELL BIOCHEM.2019;120:16088-16107. 14. CELL-SIZE PLEOMORPHISM DRIVES ABERRANT CLONE DISPERSAL IN PROLIFERATING EPITHELIA. RAMANATHAN SP, KRAJNC M, GIBSON MC. DEV CELL. 2019;51:49-61 E44. 15. PCP AND WNT PATHWAY COMPONENTS ACT IN PARALLEL DURING ZEBRAFISH MECHANOSENSORY HAIR CELL ORIENTATION. NAVAJAS ACEDO J, VOAS MG, ALEXANDER R, WOOLLEY T, UNRUH JR, LI H, MOENS C, PIOTROWSKI T. NAT COMMUN. 2019;10:3993. DOI:3910.1038/S41467-41019-12005-Y. 16. BIOCHEMICAL REDUCTION OF THE TOPOLOGY OF THE DIVERSE WDR76 PROTEIN INTERACTOME.DAYEBGADOH G, SARDIU ME, FLORENS L, WASHBURN MP. J PROTEOME RES. 2019;18:3479-3491. 17. GENERATING TOPOLOGICAL PROTEIN INTERACTION SCORES AND DATA VISUALIZATION WITH TOPS. SARDIU M, FLORENS L, WASHBURN MP. [PUBLISHED AHEAD OF PRINT SEPTEMBER 3 2019]. METHODS. 2019. 18. CLUSTERMAP: COMPARE MULTIPLE SINGLE CELL RNA-SEQ DATASETS ACROSS DIFFERENT EXPERIMENTAL CONDITIONS. GAO X, HU D, GOGOL M, LI H. BIOINFORMATICS. 2019;35:3038-3045. 19. AN ATLAS OF ANTERIOR HOX GENE EXPRESSION IN THE EMBRYONIC SEA LAMPREY HEAD: HOXCODE EVOLUTION IN VERTEBRATES. PARKER HJ, BRONNER ME, KRUMLAUF R. DEV BIOL.2019;453:19-33. 20. STABLE TRANSGENESIS IN ASTYANAX MEXICANUS USING THE TOL2 TRANSPOSASE SYSTEM.STAHL BA, PEUSS R, MCDOLE B, KENZIOR A, JAGGARD JB, GAUDENZ K, KRISHNAN J, MCGAUGH SE, DUBOUE ER, KEENE AC, ROHNER N. DEV DYN. 2019;248:679-687. 21. THE E3 UBIQUITIN LIGASE SPOP CONTROLS RESOLUTION OF SYSTEMIC INFLAMMATION BY TRIGGERING MYD88 DEGRADATION. GUILLAMOT M, OUAZIA D, DOLGALEV I, YEUNG ST,KOURTIS N, DAI Y, CORRIGAN K, ZEA-REDONDO L, SARAF A, FLORENS L, WASHBURN MP,TIKHONOVA AN, MALUMBRES M, GONG Y, TSIRIGOS A, PARK C, BARBIERI C, KHANNA KM,BUSINO L, AIFANTIS I. NAT IMMUNOL. 2019;20:1196-1207. 22. A CONSERVED REGULATORY PROGRAM INITIATES LATERAL PLATE MESODERM EMERGENCE ACROSS CHORDATES. PRUMMEL KD, HESS C, NIEUWENHUIZE S, PARKER HJ, ROGERS KW,KOZMIKOVA I, RACIOPPI C, C. BE, CZARKWIANI A, KNAPP D, BURGER S, CHIAVACCI E, SHAH G,BURGER A, HUISKEN J, YUN M, CHRISTIAEN L, KOZMIK Z, CHRISTIAEN L, MULLER P, BRONNER M,KRUMLAUF R, MOSIMANN C. NAT COMMUN. 2019;10:E3857. DOI: 3810.1038/S41467-41019-11561-41467. 23. MEASURING SIMILARITY BETWEEN GENE INTERACTION PROFILES. BARIDO-SOTTANI J,CHAPMAN SD, KOSMAN E, MUSHEGIAN AR. BMC BIOINFORMATICS. 2019;20:435. DOI:410.1186/S12859-12019-13024-X. 24. COMPARISON OF BLEACHING PROTOCOLS UTILIZING HEMATOXYLIN AND EOSIN STAIN ANDIMMUNOHISTOCHEMICAL PROLIFERATION MARKER MCM3 IN PIGMENTED MELANOMAS. JORDAN T, WILLIAMS D, CRISWELL S, WANG Y. [PUBLISHED AHEAD OF PRINT AUGUST 17 2019].J HISTOTECHNOL. 2019:1-6. 25. ALKALINE PHOSPHATASE-BASED CHROMOGENIC AND FLUORESCENCE DETECTION METHOD FOR BASESCOPE IN SITU HYBRIDIZATION. WANG Y, XU W, MADDERA L, TSUCHIYA D, THOMAS N, YU CR, PARMELY T. [PUBLISHED AUGUST 17 2019]. J HISTOTECHNOL. 2019:1-9. 26. WNT AND TGF-? COORDINATE GROWTH AND PATTERNING TO REGULATE SIZE-DEPENDENT BEHAVIOR. ARNOLD CP, BENHAM-PYLE BW, LANGE JJ, WOOD CJ, SNCHEZ ALVARADO A.NATURE. 2019;572:655-659. 27. DETECTING AND CHARACTERIZING PROTEIN SELF-ASSEMBLY IN VIVO BY FLOW CYTOMETRY.VENKATESAN S, KANDOLA TS, RODRIGUEZ-GAMA A, BOX A, HALFMANN R. J VIS EXP.2019;149:E59577. DOI: 59510.53791/59577. 28. FILLING IN THE PHYLOGENETIC GAPS: INDUCTION, MIGRATION AND DIFFERENTIATION OF NEURAL CREST CELLS IN A SQUAMATE REPTILE, THE VEILED CHAMELEON (CHAMAELEOCALYPTRATUS). DIAZ RE, JR., SHYLO NA, ROELLIG D, BRONNER M, TRAINOR PA. DEV DYN.2019;248:709-727. 29. THE TRANSCRIPTOME OF THE VEILED CHAMELEON (CHAMAELEO CALYPTRATUS): A RESOURCE FOR STUDYING THE EVOLUTION AND DEVELOPMENT OF VERTEBRATES. PINTO BJ, CARD DC, CASTOE TA, DIAZ RE, JR., NIELSEN SV, TRAINOR PA, GAMBLE T. DEV DYN. 2019;248:702-708. 30. RUNX PROTEINS DESENSITIZE MULTIPLE MYELOMA TO LENALIDOMIDE VIA PROTECTING IKZFS FROM DEGRADATION. ZHOU N, GUTIERREZ-UZQUIZA A, ZHENG XY, CHANG R, VOGL DT,GARFALL AL, BERNABEI L, SARAF A, FLORENS L, WASHBURN MP, ILLENDULA A, BUSHWELLER JH,BUSINO L. LEUKEMIA. 2019;33:2006-2021. 31. ATAXIN-7 AND NON-STOP COORDINATE SCAR PROTEIN LEVELS, SUBCELLULAR LOCALIZATION,AND ACTIN CYTOSKELETON ORGANIZATION. CLOUD V, THAPA A, MORALES-SOSA P, MILLER T,MILLER SA, HOLSAPPLE D, GERHART P, MOMTAHAN E, JACK JL, LEIVA E, RAPP SR, SHELTON LG,PIERCE RA, MARTIN-BROWN S, FLORENS L, WASHBURN MP, MOHAN RD. ELIFE. 2019;8. DOI:10.7554/ELIFE.49677. 32. STRUCTURES OF AUTOINHIBITED AND POLYMERIZED FORMS OF CARD9 REVEAL MECHANISMS OF CARD9 AND CARD11 ACTIVATION. HOLLIDAY MJ, WITT A, RODRIGUEZ GAMA A, WALTERS BT,ARTHUR CP, HALFMANN R, ROHOU A, DUEBER EC, FAIRBROTHER WJ. NAT COMMUN.2019;10:3070. DOI: 10.1038/S41467-019-10953-Z. 33. COMPREHENSIVE SINGLE-CELL TRANSCRIPTOME LINEAGES OF A PROTO-VERTEBRATE. CAO C,LEMAIRE LA, WANG W, YOON PH, CHOI YA, PARSONS LR, MATESE JC, WANG W, LEVINE M,CHEN K. NATURE. 2019;571:349-354. |
| 34. AMYLOID-LIKE ASSEMBLY ACTIVATES A PHOSPHATASE IN THE DEVELOPING |
DROSOPHILA EMBRYO. NIL Z, MILLAN RH, GERBICH T, LEAL P, YU Z, SARAF A, SARDIU M, LANGE JJ, YI K, UNRUH J, SLAUGHTER B, SI K. CELL. 2019;178:1403-1420 E1421. 35. SUPER-RESOLUTION MICROSCOPY REVEALS LINKAGES BETWEEN RIBOSOMAL DNA ON HETEROLOGOUS CHROMOSOMES. POTAPOVA TA, UNRUH JR, YU Z, RANCATI G, LI H, STAMPFER MR, GERTON JL. J CELL BIOL. 2019;218:2492-2513. 36. SIGNATURES OF DIVERGENCE, INVASIVENESS AND TERRESTRALIZATION REVEALED BY FOUR APPLE SNAIL GENOMES. SUN J, MU H, IP JCH, LI R, XU T, ACCORSI A, SNCHEZ ALVARADO A, ROSS E, LAN Y, SUN Y, CASTRO-VAZQUEZ A, VEGA IA, HERAS H, ITUARTE S, VAN BOCXLAER B, HAYES KA, COWIE RH, ZHAO Z, ZHANG Y, QIAN PY, QIU JW. MOL BIOL EVOL. 2019;36:1507-1520. 37. P53 AND B-CATENIN EXPRESSION PREDICT POORER PROGNOSIS IN PATIENTS WITH ANAPLASTIC LARGE-CELL LYMPHOMA. RICHARDSON AI, YIN CC, CUI W, LI N, MEDEIROS LJ, LI L, ZHANG D. CLIN LYMPHOMA MYELOMA LEUK. 2019;19:E385-E392. DOI: 310.1016/J.CLML.2019.1003.1030. 38. THE STOICHIOMETRY OF THE OUTER KINETOCHORE IS MODULATED BY MICROTUBULE-PROXIMAL REGULATORY FACTORS. DHATCHINAMOORTHY K, UNRUH JR, LANGE JJ, LEVY M, SLAUGHTER BD, GERTON JL. J CELL BIOL. 2019;218:2124-2135. 39. THE EXOCYST FUNCTIONS IN NICHE CELLS TO PROMOTE GERMLINE STEM CELL DIFFERENTIATION BY DIRECTLY CONTROLLING EGFR MEMBRANE TRAFFICKING. MAO Y, TU R, HUANG Y, MAO D, YANG Z, LAU PK, WANG J, NI J, GUO Y, XIE T. DEVELOPMENT. 2019;146:DEV174615 DOI: 174610.171242/DEV.174615. 40. A ROLE FOR FACT IN RNA POLYMERASE II PROMOTER-PROXIMAL PAUSING. TETTEY TT, GAO X, SHAO W, STORY BA, CHITSAZAN AD, GLASER RL, SEIDEL CW, CONAWAY RC, ZEITLINGER J, BLANCHETTE M, CONAWAY JW. CELL REP. 2019;27:3770-3779 E7. 41. JUNCTIONAL TUMOR SUPPRESSORS INTERACT WITH 14-3-3 PROTEINS TO CONTROL PLANAR SPINDLE ALIGNMENT. NAKAJIMA YI, LEE ZT, MCKINNEY SA, SWANSON SK, FLORENS L, GIBSON MC. J CELL BIOL. 2019;218:1824-1838. 42. STRUCTURE AND FUNCTION OF SPC42 COILED-COILS IN YEAST CENTROSOME ASSEMBLY AND DUPLICATION. DRENNAN AC, KRISHNA S, SEEGER MA, ANDREAS MP, GARDNER JM, SETHER EKR, JASPERSEN SL, RAYMENT I. MOL BIOL CELL. 2019;30:1505-1522. 43. KILLER MEIOTIC DRIVE AND DYNAMIC EVOLUTION OF THE WTF GENE FAMILY. EICKBUSH MT, YOUNG JM, ZANDERS SE. MOL BIOL EVOL. 2019;36:1201-1214. 44. GAMETE COLLECTION AND IN VITRO FERTILIZATION OF ASTYANAX MEXICANUS. PEUSS R, ZAKIBE Z, KRISHNAN J, MERRYMAN MS, BAUMANN DP, ROHNER N. J VIS EXP. 2019. DOI: 10.3791/59334. 45. DOWNREGULATION OF FGF SIGNALING BY SPRY4 OVEREXPRESSION LEADS TO SHAPE IMPAIRMENT, ENAMEL IRREGULARITIES, AND DELAYED SIGNALING CENTER FORMATION IN THE MOUSE MOLAR. MARANGONI P, CHARLES C, AHN Y, SEIDEL K, JHEON A, GANSS B, KRUMLAUF R, VIRIOT L, KLEIN OD. JBMR PLUS. 2019;3:E10205. DOI: 10210.11002/JBM10204.10205. 46. THE E3 UBIQUITIN LIGASE SINA REGULATES THE ASSEMBLY AND DISASSEMBLY OF THE SYNAPTONEMAL COMPLEX IN DROSOPHILA FEMALES. HUGHES SE, HEMENWAY E, GUO F, YI K, YU Z, HAWLEY RS. PLOS GENET. 2019;15:E1008161. DOI: 10.1371/JOURNAL.PGEN.1008161. 47. ARTIFICIAL RNA POLYMERASE II ELONGATION COMPLEXES FOR DISSECTING CO-TRANSCRIPTIONAL RNA PROCESSING EVENTS. NOE GONZALEZ M, CONAWAY JW, CONAWAY RC. J VIS EXP. 2019;147: DOI: 10.3791/59497. 48. HYPO-OSMOTIC-LIKE STRESS UNDERLIES GENERAL CELLULAR DEFECTS OF ANEUPLOIDY. TSAI HJ, NELLIAT AR, CHOUDHURY MI, KUCHARAVY A, BRADFORD WD, COOK ME, KIM J, MAIR DB, SUN SX, SCHATZ MC, LI R. NATURE. 2019;570:117-121. 49. YEAST CENTROSOME COMPONENTS FORM A NONCANONICAL LINC COMPLEX AT THE NUCLEAR ENVELOPE INSERTION SITE. CHEN J, GARDNER JM, YU Z, SMITH SE, MCKINNEY S, SLAUGHTER BD, UNRUH JR, JASPERSEN SL. J CELL BIOL. 2019;218:1478-1490. 50. DOPAMINE RECEPTOR ANTAGONISTS AS POTENTIAL THERAPEUTIC AGENTS FOR ADPKD. PAUL P, RAMACHANDRAN S, XIA S, UNRUH JR, CONKRIGHT-FINCHAM J, LI R. PLOS ONE. 2019;14:E0216220. DOI: 10.1371/JOURNAL.PONE.0216220. 51. REPORTER-CHIP-NEXUS REVEALS STRONG CONTRIBUTION OF THE DROSOPHILA INITIATOR SEQUENCE TO RNA POLYMERASE PAUSING. SHAO W, ALCANTARA SG, ZEITLINGER J. ELIFE. 2019;8:E41461. DOI: 41410.47554/ELIFE.41461. 52. TRANSLATION AFFECTS MRNA STABILITY IN A CODON-DEPENDENT MANNER IN HUMAN CELLS. WU Q, MEDINA SG, KUSHAWAH G, DEVORE ML, CASTELLANO LA, HAND JM, WRIGHT M, BAZZINI AA. ELIFE. 2019;8:E45396. DOI: 45310.47554/ELIFE.45396. 53. SET1-CATALYZED H3K4 TRIMETHYLATION ANTAGONIZES THE HIR/ASF1/RTT106 REPRESSOR COMPLEX TO PROMOTE HISTONE GENE EXPRESSION AND CHRONOLOGICAL LIFE SPAN. MEI Q, XU C, GOGOL M, TANG J, CHEN W, YU X, WORKMAN JL, LI S. NUCLEIC ACIDS RES. 2019;47:3434-3449. 54. EVALUATING CHROMATOGRAPHIC APPROACHES FOR THE QUANTITATIVE ANALYSIS OF A HUMAN PROTEOME ON ORBITRAP-BASED MASS SPECTROMETRY SYSTEMS. ZHANG Y, WEN Z, WASHBURN MP, FLORENS L. J PROTEOME RES. 2019;18:1857-1869. 55. DISTRIBUTION OF PROTEINS AT THE INNER NUCLEAR MEMBRANE IS REGULATED BY THE ASI1 E3 LIGASE IN SACCHAROMYCES CEREVISIAE. SMOYER CJ, SMITH SE, GARDNER JM, MCCROSKEY S, UNRUH JR, JASPERSEN SL. GENETICS. 2019;211:1269-1282. 56. DYRK1A REGULATES THE RECRUITMENT OF 53BP1 TO THE SITES OF DNA DAMAGE IN PART THROUGH INTERACTION WITH RNF169. MENON VR, ANANTHAPADMANABHAN V, SWANSON S, SAINI S, SESAY F, YAKOVLEV V, FLORENS L, DECAPRIO JA, WASHBURN MP, DOZMOROV M, LITOVCHICK L. CELL CYCLE. 2019;18:531-551. 57. A HOX-TALE REGULATORY CIRCUIT FOR NEURAL CREST PATTERNING IS CONSERVED ACROSS VERTEBRATES. PARKER HJ, DE KUMAR B, GREEN SA, PRUMMEL KD, HESS C, KAUFMAN CK, MOSIMANN C, WIEDEMANN LM, BRONNER ME, KRUMLAUF R. NAT COMMUN. 2019;10:1189. DOI: 1110.1038/S41467-41019-09197-41468. 58. TOPOLOGICAL SCORING OF PROTEIN INTERACTION NETWORKS. SARDIU ME, GILMORE JM, GROPPE BD, DUTTA A, FLORENS L, WASHBURN MP. NAT COMMUN. 2019;10:1118. DOI: 1110.1038/S41467-41019-09123-Y. 59. IMAGING-BASED ASSAYS FOR INVESTIGATING FUNCTIONS OF THE RNA POLYMERASE II ELONGATION FACTOR ELONGIN AND THE ELONGIN UBIQUITIN LIGASE. WEEMS JC, UNRUH JR, SLAUGHTER BD, CONAWAY RC, CONAWAY JW. METHODS. 2019;159-160:157-164. 60. CHARACTERIZATION OF A METAZOAN ADA ACETYLTRANSFERASE COMPLEX. SOFFERS JHM, LI X, SARAF A, SEIDEL CW, FLORENS L, WASHBURN MP, ABMAYR SM, WORKMAN JL. NUCLEIC ACIDS RES. 2019;47:3383-3394. 61. A CHEMOPROTEOMIC PORTRAIT OF THE ONCOMETABOLITE FUMARATE. KULKARNI RA, BAK DW, WEI D, BERGHOLTZ SE, BRINEY CA, SHRIMP JH, ALPSOY A, THORPE AL, BAVARI AE, CROOKS DR, LEVY M, FLORENS L, WASHBURN MP, FRIZZELL N, DYKHUIZEN EC, WEERAPANA E, LINEHAN WM, MEIER JL. NAT CHEM BIOL. 2019;15:391-400 62. HOST VESICLE FUSION PROTEIN VAPB IS REQUIRED FOR THE NUCLEAR EGRESS STAGE OF HERPES SIMPLEX VIRUS TYPE-1 (HSV-1) REPLICATION. SAIZ-ROS N, CZAPIEWSKI R, EPIFANO I, STEVENSON A, SWANSON SK, DIXON CR, ZAMORA DB, MCELWEE M, VIJAYAKRISHNAN S, RICHARDSON CA, DONG L, KELLY DA, PYTOWSKI L, GOLDBERG MW, FLORENS L, GRAHAM SV, SCHIRMER EC. CELLS. 2019;8 E120. DOI: 110.3390/CELLS8020120. 63. TOWARDS THE MOLECULAR DECIPHERING OF POMACEA CANALICULATA IMMUNITY: FIRST PROTEOMIC ANALYSIS OF CIRCULATING HEMOCYTES. BORALDI F, LOFARO FD, ACCORSI A, ROSS E, MALAGOLI D. PROTEOMICS. 2019;19:E1800314. DOI: 1800310.1801002/PMIC.XXX-XX-XXXX. 64. DEFINING GENE NETWORKS CONTROLLING THE MAINTENANCE AND FUNCTION OF THE DIFFERENTIATION NICHE BY AN IN VIVO SYSTEMATIC RNAI SCREEN. GAO Y, MAO Y, XU RG, ZHU R, ZHANG M, SUN J, SHEN D, PENG P, XIE T, NI JQ. J GENET GENOME. 2019;46:19-30. 65. SCRNA-SEQ REVEALS DISTINCT STEM CELL POPULATIONS THAT DRIVE HAIR CELL REGENERATION AFTER LOSS OF FGF AND NOTCH SIGNALING. LUSH ME, DIAZ DC, KOENECKE N, BAEK S, BOLDT H, ST PETER MK, GAITAN-ESCUDERO T, ROMERO-CARVAJAL A, BUSCH-NENTWICH EM, PERERA AG, HALL KE, PEAK A, HAUG JS, PIOTROWSKI T. ELIFE. 2019;8:E44431. DOI: 44410.47554/ELIFE.44431. 66. N-CADHERIN-EXPRESSING BONE AND MARROW STROMAL PROGENITOR CELLS MAINTAIN RESERVE HEMATOPOIETIC STEM CELLS. ZHAO M, TAO F, VENKATRAMAN A, LI Z, SMITH SE, UNRUH J, CHEN S, WARD C, QIAN P, PERRY JM, MARSHALL H, WANG J, HE XC, LI L. CELL REP. 2019;26:652-669 E656. 67. THE DROSOPHILA DBF4 ORTHOLOG CHIFFON FORMS A COMPLEX WITH GCN5 THAT IS NECESSARY FOR HISTONE ACETYLATION AND VIABILITY. TORRES-ZELADA EF, STEPHENSON RE, ALPSOY A, ANDERSON BD, SWANSON SK, FLORENS L, DYKHUIZEN EC, WASHBURN MP, WEAKE VM. J CELL SCI. 2019;132:JCS.214072. 68. ELECTROPORATION OF SHORT HAIRPIN RNAS FOR RAPID AND EFFICIENT GENE KNOCKDOWN IN THE STARLET SEA ANEMONE, NEMATOSTELLA VECTENSIS. KARABULUT A, HE S, CHEN CY, MCKINNEY SA, GIBSON MC. DEV BIOL. 2019;448:7-15. 69. OOCYTE-SPECIFIC DELETION OF HDAC8 IN MICE REVEALS STAGE-SPECIFIC EFFECTS ON FERTILITY. SINGH VP, YUEH WT, GERTON JL, DUNCAN FE. REPRODUCTION. 2019;157:305-316. 70. NARYA, A RING FINGER DOMAIN-CONTAINING PROTEIN, IS REQUIRED FOR BOTH MEIOTIC DNA DOUBLE-STRAND BREAK FORMATION AND CROSSOVER MATURATION IN DROSOPHILA MELANOGASTER. LAKE CM, NIELSEN RJ, BONNER AM, ECHE S, WHITE-BROWN S, MCKIM KS, HAWLEY RS. PLOS GENET. 2019;15:E1007886. DOI:1007810.1001371/JOURNAL.PGEN.1007886. |
| 71. SHH PLAYS AN INHIBITORY ROLE IN CUSP PATTERNING BY REGULATION OF |
SOSTDC1. KIM J, AHN Y, ADASOORIYA D, WOO EJ, KIM HJ, HU KS, KRUMLAUF R, CHO SW. J DENT RES. 2019;98:98-106. 72. FUNCTIONAL CONSEQUENCES OF THE EVOLUTION OF MATRIMONY, A MEIOSIS-SPECIFIC INHIBITOR OF POLO KINASE. BONNER AM, HAWLEY RS. MOL BIOL EVOL. 2019;36:69-83. 73. GLYCOLYSIS REGULATES GENE EXPRESSION BY PROMOTING THE CROSSTALK BETWEEN H3K4 TRIMETHYLATION AND H3K14 ACETYLATION IN SACCHAROMYCES CERVISIAE. WU Y, ZHANG S, GONG X, YU Q, ZHANG Y, LUO M, ZHANG X, WORMAN JL, YU X, LI S. J GENET GENOMICS. 2019;46:561-574. 74. UNIDIRECTIONAL PROPULSION OF PLANAR MAGNETIC NANOMACHINES. COHEN K-J, RUBINSTEIN BY, KENNETH O, LESHANSKY AM. PHYS REV APPLIED. 2019;12:014025:1-10. REVIEWS, COMMENTARIES, CHAPTERS, AND BOOKS 1. CONTINUING THE ADVANCEMENT OF JOURNAL OF HISTOTECHNOLOGY - ONE ISSUE AT A TIME. WANG Y. J HISTOTECHNOL. 2019;42:165-166. 2. EXOGENOUS PYRUVATE REPRESSES HISTONE GENE EXPRESSION AND INHIBITS CANCER CELL PROLIFERATION VIA THE NAMPT-NAD+-SIRT1 PATHWAY. MA R, WU Y, ZHAI Y, HU B, MA W, YANG W, YU Q, CHEN Z, WORKMAN JL, YU X, LI S. NUCLEIC ACIDS RES. 2019;47:11132-11150. 3. THE JOY OF BALANCERS. MILLER DE, COOK KR, HAWLEY RS. PLOS GENET. 2019;15:E1008421. DOI: 1008410.1001371/JOURNAL.PGEN.1008421. 4. REBOOTING THE EPIGENOME: ERASURE OF PARENTAL HISTONE MARKS FOR ESTABLISHING THE REGULATORY LANDSCAPE IN ZYGOTES. BHATTACHARYA S, WORKMAN JL. [PUBLISHED AHEAD OF PRINT OCTOBER 23 2019]. BIOCHEMISTRY. 2019. 5. BEYOND BASIC AT THE STOWERS INSTITUTE FOR MEDICAL RESEARCH. BLAND K, ORR AA. MO MED. 2019;116:457-460. 6. AN INTERDISCIPLINARY APPROACH TO INVESTIGATE COLLECTIVE CELL MIGRATION IN NEURAL CREST. GINIUNAITE R, MCLENNAN R, MCKINNEY MC, BAKER RE, KULESA PM, MAINI PK. [PUBLISHED AHEAD OF PRINT OCTOBER 18 2019]. DEV DYN. 2019. 7. PURIFICATION AND ENZYMATIC ASSAY OF CLASS I HISTONE DEACETYLASE ENZYMES. ADAMS MK, BANKS CAS, MIAH S, KILLER M, WASHBURN MP. METHODS ENZYMOL. 2019;626:23-40. 8. COMPARING SENSORY ORGANS TO DEFINE THE PATH FOR HAIR CELL REGENERATION. DENANS N, BAEK S, PIOTROWSKI T. ANNU REV CELL DEV BIOL. 2019;35:568-589. 9. NSL COMPLEX ACETYLATES LAMIN A/C. POPOVA VV, WORKMAN JL. NAT CELL BIOL. 2019;21:1177-1178. 10. PATROLLING THE NUCLEUS: INNER NUCLEAR MEMBRANE-ASSOCIATED DEGRADATION. SMOYER CJ, JASPERSEN SL. CURR GENET. 2019;65:1099-1106. 11. THE HUNT FOR RNA POLYMERASE II ELONGATION FACTORS: A HISTORICAL PERSPECTIVE. CONAWAY RC, CONAWAY JW. NAT STRUCT MOL BIOL. 2019;26:771-776. 12. REGULATION OF GENOMIC OUTPUT AND (PLURI)POTENCY IN REGENERATION. DUNCAN EM, SNCHEZ ALVARADO A. ANNU REV GENET. 2019;53:16.1-16.20. 13. CNIDOFEST 2018: THE FUTURE IS BRIGHT FOR CNIDARIAN RESEARCH. HE S, GRASIS JA, NICOTRA ML, JULIANO CE, SCHNITZLER CE. EVODEVO. 2019;10:20. DOI: 10.1186/S13227-13019-10134-13225. 14. HISTONE LYSINE DE-BETA-HYDROXYBUTYRYLATION BY SIRT3. ABMAYR SM, WORKMAN JL. CELL RES. 2019;29:694-695. 15. GENE CONVERSION GENERATES EVOLUTIONARY NOVELTY THAT FUELS GENETIC CONFLICTS. DAUGHERTY MD, ZANDERS SE. V.CURR OPIN GENET DE 2019;58:49-54. 16. A FAMILY OF KILLERS. DE CARVALHO M, ZANDERS SE. ELIFE. 2019;8:E46454. DOI: 46410.47554/ELIFE.46454. 17. WHEN MOTHERS LEAVE THEIR MARK. BARAJAS-AZPELETA R, SI K. ELIFE. 2019;8:E48899. DOI:48810.47554/ELIFE.48899. 18. HEMATOPOIETIC STEM CELLS: SELF-RENEWAL AND EXPANSION. LI Z, HE XC, LI L. CURR OPIN HEMATOL. 2019;26:258-265. 19. FERTILITY COSTS OF MEIOTIC DRIVERS. ZANDERS SE, UNCKLESS RL. CURR BIOL. 2019;29:R512-R520. 20. CORNELIA DE LANGE SYNDROME, RELATED DISORDERS, AND THE COHESIN COMPLEX: ABSTRACTS FROM THE 8TH BIENNIAL SCIENTIFIC AND EDUCATIONAL SYMPOSIUM 2018. KLINE AD, KRANTZ ID, BANDO M, SHIRAHIGE K, CHEA S, SAKATA T, RAO S, DORSETT D, SINGH VP, GERTON JL, HORSFIELD JA, CALOF AL, KATZ O, GRADOS M, RAIBLE S, BARANANO K, LYON G, MUSIO A, CARRICO CS, CLEMENS DK, CAUDILL P, MASSA V, MCGILL BE, DOMMESTRUP A, O'CONNOR J, HAALAND RE. AM J MED GENET A. 2019;179:1030-1090. 21. HOX GENES: DOWNSTREAM "EFFECTORS" OF RETINOIC ACID SIGNALING IN VERTEBRATE EMBRYOGENESIS. NOLTE C, DE KUMAR B, KRUMLAUF R. GENESIS. 2019:E23306. DOI:10.1002/DVG.23306. 22. NICHE CELLS REWIRED TO MAINTAIN HSCS EX VIVO. VENKATRAMAN A, LI L. NAT CELL BIOL. 2019;21:540-541. 23. COMMENTARY ON "REGENERATION, DUPLICATION AND TRANSDETERMINATION IN FRAGMENTS OF THE LEG DISC OF DROSOPHILA MELANOGASTER": SCHUBIGER, G. (1971). DEV BIOL. 2019;449:63-82.. GIBSON MC. DEV BIOL. 2019;449:63-82. 24. IN OVO ELECTROPORATION OF PLASMID DNA AND MORPHOLINOS INTO SPECIFIC TISSUES DURING EARLY EMBRYOGENESIS. MCLENNAN R, KULESA PM. METHODS MOL BIOL.2019;1976:71-82. 25. MOUSE EMBRYO CULTURE FOR THE STUDY OF NEURAL CREST CELLS. MUNOZ WA, TRAINOR PA. METHODS MOL BIOL: MEIOSIS. 2019;1976:107-119. 26. OBSERVATION OF TWO SEPARATE BIPOLAR SPINDLES IN THE HUMAN ZYGOTE. XU, X., LI L, ZHANG C, MENG L. J ASSIST REPROD GENET. 2019;36:601-602. CORRECTION: J ASSIST REPROD GENET. 2019 JUL 31. PII: 10.1007/S10815-019-01539-1. DOI: 10.1007/S10815-019-01539-1. 27. SWEET FISH: FISH MODELS FOR THE STUDY OF HYPERGLYCEMIA AND DIABETES. KRISHNAN J, ROHNER N. J DIABETES. 2019;11:193-203. 28. RIBOSOMAL DNA INSTABILITY AND GENOME ADAPTABILITY. SALIM D, GERTON JL. CHROMOSOME RES. 2019;27:73-87. 29. RIBOSOMAL DNA AND THE NUCLEOLUS IN THE CONTEXT OF GENOME ORGANIZATION. POTAPOVA TA, GERTON JL. CHROMOSOME RES. 2019;27:109-127. 30. THE SOCIETY FOR CRANIOFACIAL GENETICS AND DEVELOPMENTAL BIOLOGY 41ST ANNUAL MEETING. TANEYHILL LA, MOODY SA, COX T, KLEIN OD, MARCUCIO R, SCHNEIDER RA, TRAINOR PA. AM J MED GENET A. 2019;179:864-869. 31. MANIPULATION OF DEVELOPMENTAL FUNCTION IN TURTLES WITH NOTES ON ALLIGATORS. MOUSTAKAS-VERHO JE, MCLENNAN R, SPENGLER J, KULESA PM, CEBRA-THOMAS JA. METHODS MOL BIOL. 2019;1920:247-263. AUTHOR'S CORRECTION: METHODS MOL BIOL. 2019;1920:C1. 32. AN INTEGRATIVE VIEW OF LEPIDOSAUR CRANIAL ANATOMY, DEVELOPMENT AND DIVERSIFICATION. DIAZ JR. RE, TRAINOR PA. IN: ZIERMANN, D JR., AND DIOGO, EDS. HEADS, JAWS AND MUSCLES ANATOMICAL, FUNCTIONAL AND DEVELOPMENTAL DIVERSITY IN CHORDATE EVOLUTION, SPRINGER; 2019:207-227. 33. RIBOSOMAL DNA-CONNECTING RIBOSOME BIOGENESIS AND CHROMOSOME BIOLOGY. POROKHOVNIK L, GERTON JL. CHROMOSOME RES. 2019;27:1-3. 34. RECENT ADVANCES IN UNDERSTANDING INTESTINAL STEM CELL REGULATION. HU D, YAN H, HE XC, LI L. F1000RES. 2019;8:F1000 FACULTY REV-72. PUBLISHED 2019 JAN 18. DOI:10.12688/F1000RESEARCH.16793.1 COMPETITIVE RESEARCH GRANT FUNDING & RESEARCH AWARDS & DISTINCTIONS THE ABILITY OF SIMR SCIENTISTS TO RECEIVE COMPETITIVELY AWARDED RESEARCH FUNDING ATTESTS TO THE HIGH LEVEL OF RESEARCH PRODUCTIVITY PRESENT AT SIMR. DURING 2019, SIMR SCIENTISTS WORKED WITH THE SUPPORT OF 31 GRANTS AND FELLOWSHIPS FROM THE NATIONAL INSTITUTES OF HEALTH, TWO GRANTS FROM THE NATIONAL SCIENCE FOUNDATION, TWO GRANTS FROM THE MARCH OF DIMES, ONE GRANT FROM THE GREATER KANSAS CITY COMMUNITY FOUNDATION, ONE GRANT FROM THE HEARING HEALTH FOUNDATION, ONE FELLOWSHIP FROM THE JANE COFFIN CHILDS MEMORIAL FUND, ONE AWARD FROM THE SEARLE SCHOLARS PROGRAM, ONE AWARD FROM THE PEW CHARITABLE TRUSTS, ONE AWARD FROM THE UNIVERSITY OF KANSAS ENDOWMENT ASSOCIATION, ONE GRANT FROM THE EDWARD MALLINCKRODT JR. FOUNDATION, ONE GRANT FROM THE JUVENILE DIABETES RESEARCH FOUNDATION, ONE GRANT FROM THE UNIVERSITY OF KANSAS ALZHEIMER'S DISEASE CENTER, ONE GRANT FROM THE UNIVERSITY OF KANSAS CANCER CENTER, AND ONE INVESTIGATOR AWARD FROM THE HOWARD HUGHES MEDICAL INSTITUTE. SUPPORT FROM NEW AND CONTINUING AWARDS TO SIMR TOTALED MORE THAN $6.2 MILLION IN 2019 TO SUPPLEMENT INCOME FROM ITS ENDOWMENTS. TESTIFYING TO THE HIGH LEVEL OF ACHIEVEMENT TAKING PLACE AT SIMR ARE THE AWARDS AND HONORS SIMR MEMBERS RECEIVED IN 2019: 1. NICOLAS ROHNER, PHD, RECEIVED A TWO-YEAR GRANT FROM THE JUVENILE DIABETES RESEARCH FOUNDATION 2. TING XIE, PHD, WAS AWARDED A FIVE-YEAR GRANT FROM THE NIH EUNICE SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT 3. LINHENG LI, PHD, RECEIVED A FIVE-YEAR GRANT FROM THE NIH NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES 4. ARIEL BAZZINI, PHD, RECEIVED A TWO-YEAR PEW INNOVATION FUND AWARD ALONG WITH COLLABORATOR DIEGO ALVAREZ, PHD, FROM THE NATIONAL UNIVERSITY OF SAN MARTIN, ARGENTINA 5. RANDAL HALFMANN, PHD, RECEIVED A FOUR-YEAR NIH GRANT FROM THE NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES 6. ERIC HILL, PHD, A POSTDOCTORAL RESEARCHER IN THE GIBSON LAB, WAS AWARDED A TWOYEAR NIH FELLOWSHIP FROM THE NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES 7. CASSANDRA KEMPF, A PREDOCTORAL RESEARCHER OF THE GRADUATE SCHOOL OF THE STOWERS INSTITUTE, RECEIVED A THREE-YEAR FELLOWSHIP FROM THE NIH NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES 8. STACEY HANLON, PHD, A POSTDOCTORAL RESEARCHER IN THE HAWLEY LAB, WAS AWARDED A TWO-YEAR GRANT FROM THE NIH EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT 9. JOSEPH VARBERG, PHD, A POSTDOCTORAL RESEARCHER IN THE JASPERSEN LAB, RECEIVED A ONE-YEAR NIH NRSA POSTDOCTORAL FELLOWSHIP |
| 10. JIANZHENG WU, A UNIVERSITY OF KANSAS MEDICAL CENTER PREDOCTORAL |
RESEARCHER IN THE HALFMANN LAB, WAS AWARDED A ONE-YEAR FELLOWSHIP FROM THE UNIVERSITY OF KANSAS MEDICAL CENTER INSTITUTE FOR NEUROLOGICAL DISCOVERIES INDEPENDENT RESEARCH PROGRAM LEADERS LABORATORIES INDIVIDUAL SCIENTISTS AT THE SIMR SPECIALIZE IN THE STUDY OF ONE OR MORE PARTICULAR GENES, PROTEINS, OR OTHER MOLECULES, EACH OF WHICH MAY CAUSE OR INFLUENCE VARIOUS KINDS OF DISEASE. A COMPREHENSIVE LIST OF RESEARCH LEADERS FOLLOWS: 1. ALEJANDRO SNCHEZ ALVARADO, PHD, SCIENTIFIC DIRECTOR, INVESTIGATOR, AND HOWARD HUGHES MEDICAL INSTITUTE INVESTIGATOR, JOINED SIMR IN 2011 FROM THE UNIVERSITY OF UTAH'S SCHOOL OF MEDICINE, WHERE HE HELD THE H.A. & EDNA BENNING PROFESSORSHIP OF NEUROBIOLOGY AND ANATOMY. HE RECEIVED A BS IN MOLECULAR BIOLOGY AND CHEMISTRY FROM VANDERBILT UNIVERSITY IN NASHVILLE, TENN., AND A PHD IN PHARMACOLOGY AND CELL BIOPHYSICS FROM THE UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE IN CINCINNATI, OHIO. RESEARCH FOCUS: THE MOLECULAR AND CELLULAR MECHANISMS UNDERPINNING ANIMAL REGENERATION USING THE PLANARIAN SCHMIDTEA MEDITERRANEA AS A MODEL SYSTEM. 2. ARIEL BAZZINI, PHD, ASSISTANT INVESTIGATOR, JOINED SIMR IN 2016 FROM THE LAB OF ANTONIO J. GIRALDEZ, PHD, IN THE DEPARTMENT OF GENETICS AT YALE UNIVERSITY, WHERE HE COMPLETED A POSTDOCTORAL FELLOWSHIP. DR. BAZZINI RECEIVED HIS PHD IN MOLECULAR BIOLOGY AT THE UNIVERSITY OF BUENOS AIRES, ARGENTINA. FOR HIS DOCTORAL DISSERTATION, HE STUDIED PLANT GENETICS AT THE INSTITUTE OF BIOTECHNOLOGY IN ARGENTINA'S NATIONAL INSTITUTE OF AGRICULTURAL TECHNOLOGY (INTA). RESEARCH FOCUS: THE REGULATION OF GENE EXPRESSION IN VERTEBRATES. 3. JOAN CONAWAY, PHD, INVESTIGATOR, JOINED SIMR IN 2001 FROM THE OKLAHOMA MEDICAL RESEARCH FOUNDATION WHERE SHE WAS AN ASSOCIATE INVESTIGATOR OF THE HOWARD HUGHES MEDICAL INSTITUTE AND INTERIM HEAD OF THE PROGRAM IN MOLECULAR AND CELL BIOLOGY. DR. CONAWAY RECEIVED HER DOCTORATE IN CELL BIOLOGY FROM STANFORD UNIVERSITY SCHOOL OF MEDICINE. RESEARCH FOCUS: ANALYSIS OF THE MOLECULAR MECHANISM AND REGULATION OF GENE TRANSCRIPTION. 4. RONALD CONAWAY, PHD, INVESTIGATOR, JOINED SIMR IN 2001 FROM THE OKLAHOMA MEDICAL RESEARCH FOUNDATION WHERE HE WAS HOLDER OF THE CHAPMAN CHAIR IN MEDICAL RESEARCH. DR. CONAWAY RECEIVED HIS PHD IN BIOCHEMISTRY FROM STANFORD UNIVERSITY SCHOOL OF MEDICINE. RESEARCH FOCUS: ANALYSIS OF THE MOLECULAR MECHANISM AND REGULATION OF GENE TRANSCRIPTION. 5. JENNIFER GERTON, PHD, INVESTIGATOR, JOINED SIMR IN 2002 FROM A POSTDOCTORAL FELLOWSHIP IN THE LABORATORY OF DR. JOSEPH DERISI IN THE DEPARTMENT OF BIOCHEMISTRY AND BIOPHYSICS AT THE UNIVERSITY OF CALIFORNIA-SAN FRANCISCO. DR. GERTON RECEIVED A PHD IN MICROBIOLOGY AND IMMUNOLOGY FROM STANFORD UNIVERSITY. RESEARCH FOCUS: GENOMIC AND GENETIC ANALYSIS OF CHROMOSOME SEGREGATION AND CHROMOSOME DYNAMICS. 6. MATTHEW GIBSON, PHD, INVESTIGATOR AND DEAN OF THE GRADUATE SCHOOL, JOINED SIMR IN 2006 FROM A JANE COFFIN CHILDS MEMORIAL FUND POSTDOCTORAL FELLOWSHIP WITH DR. NORBERT PERRIMON AT HARVARD MEDICAL SCHOOL. DR. GIBSON RECEIVED A PHD IN ZOOLOGY FROM THE UNIVERSITY OF WASHINGTON. RESEARCH FOCUS: GENETIC ANALYSIS OF MECHANISMS CONTROLLING SIGNAL TRANSDUCTION, CELL PROLIFERATION, AND EPITHELIAL MORPHOGENESIS DURING DROSOPHILA DEVELOPMENT. 7. RANDAL HALFMANN, PHD, ASSISTANT INVESTIGATOR, JOINED SIMR IN 2015 FROM THE UNIVERSITY OF TEXAS (UT) SOUTHWESTERN MEDICAL CENTER. HE RECEIVED A PHD IN BIOLOGY FROM THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY, WHERE HE WAS A NATIONAL SCIENCE FOUNDATION PREDOCTORAL FELLOW. AFTER COMPLETING HIS GRADUATE STUDIES, DR. HALFMANN OBTAINED AN INDEPENDENT POSITION AT UT SOUTHWESTERN MEDICAL CENTER WHERE HE WAS A SARA AND FRANK MCKNIGHT FELLOW AND RECEIVED A DIRECTOR'S EARLY INDEPENDENCE AWARD FROM THE NATIONAL INSTITUTES OF HEALTH. RESEARCH FOCUS: CELLULAR AND EVOLUTIONARY IMPLICATIONS OF PROTEIN SELF-ASSEMBLY USING GENETIC, BIOCHEMICAL, AND CELL-BIOLOGICAL APPROACHES. 8. R. SCOTT HAWLEY, PHD, INVESTIGATOR AND DEAN EMERITUS OF THE GRADUATE SCHOOL, JOINED SIMR IN 2001 FROM THE UNIVERSITY OF CALIFORNIA-DAVIS WHERE HE WAS A PROFESSOR OF GENETICS IN THE MOLECULAR AND CELLULAR BIOLOGY SECTION. DR. HAWLEY EARNED A PHD IN GENETICS FROM THE UNIVERSITY OF WASHINGTON AND COMPLETED POSTDOCTORAL TRAINING AS A HELEN HAY WHITNEY FELLOW AT THE INSTITUTE FOR CANCER RESEARCH IN PHILADELPHIA. RESEARCH FOCUS: INVESTIGATION OF MECHANISMS THAT INFLUENCE HOW CHROMOSOMES PAIR AND SEGREGATE DURING MEIOSIS USING DROSOPHILA AS AN EXPERIMENTAL SYSTEM. 9. SUE JASPERSEN, PHD, ASSOCIATE INVESTIGATOR, JOINED SIMR IN 2005 FROM THE LABORATORY OF DR. MARK WINEY AT THE UNIVERSITY OF COLORADO-BOULDER WHERE SHE WAS A KECK FOUNDATION FELLOW, A HELEN HAY WHITNEY FELLOW, AND THE RECIPIENT OF A LEUKEMIA & LYMPHOMA SOCIETY CAREER DEVELOPMENT AWARD. DR. JASPERSEN HOLDS A PHD IN BIOCHEMISTRY FROM THE UNIVERSITY OF CALIFORNIA-SAN FRANCISCO. RESEARCH FOCUS: INNER NUCLEAR MEMBRANE PROTEIN LOCALIZATION AND ROLE IN CHROMOSOME POSITIONING AND SEGREGATION. 10. ROBERT KRUMLAUF, PHD, SCIENTIFIC DIRECTOR EMERITUS AND INVESTIGATOR, JOINED THE SIMR IN 2000 FROM ENGLAND'S NATIONAL INSTITUTE FOR MEDICAL RESEARCH, THE RIDGEWAY, MILL HILL, LONDON, WHERE HE WAS HEAD OF THE DIVISION OF DEVELOPMENTAL NEUROBIOLOGY. DR. KRUMLAUF RECEIVED A PHD IN DEVELOPMENTAL BIOLOGY FROM OHIO STATE UNIVERSITY. RESEARCH FOCUS: ANALYSIS OF MOLECULAR PATHWAYS THAT REGULATE HOW THE MAMMALIAN HEAD, BRAIN AND NERVOUS SYSTEM ARE BUILT, USING A VARIETY OF VERTEBRATE MODEL SYSTEMS. 11. LINHENG LI, PHD, INVESTIGATOR, JOINED SIMR IN 2000 FROM THE UNIVERSITY OF WASHINGTON MEDICAL CENTER WHERE HE HELD A FACULTY APPOINTMENT AFTER COMPLETING POSTDOCTORAL TRAINING IN THE LABORATORY DIRECTED BY DR. LEROY HOOD. DR. LI EARNED HIS PHD IN MOLECULAR AND CELLULAR BIOLOGY FROM NEW YORK UNIVERSITY MEDICAL SCHOOL UNDER THE MENTORING OF DR. EDWARD ZIFF. RESEARCH FOCUS: INVESTIGATION OF MOLECULAR AND GENETIC PATHWAYS CONTROLLING ADULT STEM CELL DEVELOPMENT IN THE HEMATOPOIETIC AND INTESTINAL SYSTEMS USING TRANSGENIC AND GENE TARGETING ANIMAL MODEL APPROACHES. 12. TATJANA PIOTROWSKI, PHD, INVESTIGATOR, JOINED SIMR IN 2011 FROM THE UNIVERSITY OF UTAH'S SCHOOL OF MEDICINE, WHERE SHE WAS AN ASSOCIATE PROFESSOR IN THE DEPARTMENT OF NEUROBIOLOGY AND ANATOMY. SHE RECEIVED HER MASTER'S DEGREE FROM THE UNIVERSITY OF TUBINGEN, GERMANY, AND HER DOCTORATE DEGREE FROM THE MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY IN TUBINGEN. RESEARCH FOCUS: COLLECTIVE CELL MIGRATION, CELL TYPE SPECIFICATION AND STEM CELL BIOLOGY IN ZEBRAFISH AS A MODEL SYSTEM. 13. NICOLAS ROHNER, PHD, ASSISTANT INVESTIGATOR, JOINED SIMR IN 2015 FROM HARVARD MEDICAL SCHOOL, WHERE HE WAS A POSTDOCTORAL FELLOW IN DR. CLIFF TABIN'S LABORATORY. HE EARNED A PHD IN BIOLOGY FROM THE MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY IN TUBINGEN, GERMANY. RESEARCH FOCUS: GENETIC MECHANISMS AND MUTATIONS THAT UNDERLIE THE ANIMAL KINGDOM'S TREMENDOUS DIVERSITY IN MORPHOLOGY, PHYSIOLOGY, AND BEHAVIOR. 14. KAUSIK SI, PHD, ASSOCIATE SCIENTIFIC DIRECTOR AND INVESTIGATOR, JOINED SIMR IN 2005FROM THE LABORATORY OF DR. ERIC KANDEL AT COLUMBIA UNIVERSITY CENTER FOR NEUROBIOLOGY AND BEHAVIOR WHERE HE WAS A JANE COFFIN CHILDS FELLOW AND A FRANCIS GOELET FELLOW IN NEUROSCIENCE. DR. SI EARNED A PHD IN MOLECULAR BIOLOGY FROM THE ALBERT EINSTEIN COLLEGE OF MEDICINE. RESEARCH FOCUS: ROLE OF SYNAPTIC PROTEIN SYNTHESIS IN INFORMATION ACQUISITION AND MEMORY STORAGE. 15. PAUL TRAINOR, PHD, INVESTIGATOR, JOINED SIMR IN 2001 FROM A RESEARCH POSITION AT THE NATIONAL INSTITUTE FOR MEDICAL RESEARCH AT MILL HILL, LONDON, WHERE HE COMPLETED POSTDOCTORAL TRAINING. DR. TRAINOR HAS A PHD IN DEVELOPMENTAL BIOLOGY FROM CHILDREN'S MEDICAL RESEARCH INSTITUTE AT THE UNIVERSITY OF SYDNEY, AUSTRALIA. RESEARCH FOCUS: INVESTIGATION OF THE INTERACTIONS BETWEEN DISTINCT TISSUES IN THE BODY AND THEIR REGULATION DURING NORMAL DEVELOPMENT TO REVEAL PATHWAYS THAT REGULATE NORMAL CRANIAL AND FACIAL DEVELOPMENT. 16. JERRY WORKMAN, PHD, INVESTIGATOR, JOINED SIMR IN 2003 FROM THE PENNSYLVANIA STATE UNIVERSITY WHERE HE HELD THE PAUL BERG PROFESSORSHIP OF BIOCHEMISTRY AND WAS AN ASSOCIATE INVESTIGATOR OF THE HOWARD HUGHES MEDICAL INSTITUTE. DR. WORKMAN EARNED A PHD IN CELL AND MOLECULAR BIOLOGY FROM THE UNIVERSITY OF MICHIGAN AND COMPLETED POSTDOCTORAL TRAINING AT THE ROCKEFELLER UNIVERSITY WITH DR. BOB ROEDER. RESEARCH FOCUS: STUDY OF THE PROTEIN COMPLEXES THAT MODIFY CHROMATIN. 17. TING XIE, PHD, INVESTIGATOR, JOINED SIMR IN 2000 AFTER COMPLETING A HOWARD HUGHES MEDICAL INSTITUTE POSTDOCTORAL FELLOWSHIP IN THE LABORATORY OF DR. ALLAN C. SPRADLING AT THE CARNEGIE INSTITUTION OF WASHINGTON. DR. XIE RECEIVED HIS PHD FROM THE JOINT GRADUATE PROGRAM IN MOLECULAR BIOLOGY AND BIOCHEMISTRY OF RUTGERS UNIVERSITY AND THE UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY. RESEARCH FOCUS: GENETIC AND MOLECULAR ANALYSIS OF STEM CELLS AND GERM CELL DEVELOPMENT IN DROSOPHILA AND MOUSE. |
| 18. C. RON YU, PHD, INVESTIGATOR, JOINED SIMR IN 2005 FROM THE LABORATORY |
OF DR. RICHARD AXEL AT COLUMBIA UNIVERSITY CENTER FOR NEUROBIOLOGY AND BEHAVIOR WHERE HE HELD A NATIONAL INSTITUTES OF HEALTH MENTORED RESEARCH SCIENTIST AWARD FROM THE NATIONAL INSTITUTE OF MENTAL HEALTH. DR. YU EARNED HIS PHD IN MOLECULAR, CELLULAR, AND BIOPHYSICAL STUDIES AT COLUMBIA UNIVERSITY. RESEARCH FOCUS: HOW OLFACTORY SENSORY INFORMATION IS DETECTED, INTEGRATED, AND PROCESSED IN THE BRAIN TO INFLUENCE SPECIFIC INNATE BEHAVIORS. 19. SARAH ZANDERS, PHD, ASSISTANT INVESTIGATOR AND VICE DEAN OF THE GRADUATE SCHOOL, JOINED SIMR IN 2016 AFTER COMPLETION OF HER POSTDOCTORAL TRAINING IN BASIC SCIENCES AT THE FRED HUTCHINSON CANCER RESEARCH CENTER (FHCRC) WITH SUPPORT FROM A PATHWAY TO INDEPENDENCE AWARD FROM THE NATIONAL INSTITUTES OF HEALTH. FHCRC FACULTY MEMBERS HARMIT S. MALIK, PHD, AND GERRY SMITH, PHD, ADVISED HER RESEARCH ON FERTILITY, GENOME EVOLUTION, AND THE ORIGIN OF NEW SPECIES. DR. ZANDERS RECEIVED HER PHD IN GENETICS AND DEVELOPMENT FROM CORNELL UNIVERSITY. RESEARCH FOCUS: THE EFFECTS OF GENETIC CONFLICTS CAUSED BY SELFISH GENES THAT ARE EMBEDDED IN EUKARYOTIC GENOMES. 20. JULIA ZEITLINGER, PHD, INVESTIGATOR, JOINED SIMR IN 2007 FROM THE LAB OF DR. RICHARD YOUNG AT THE WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH AT MASSACHUSETTS INSTITUTE OF TECHNOLOGY WHERE SHE WAS THE RECIPIENT OF A LONG-TERM POSTDOCTORAL FELLOWSHIP FROM THE HUMAN FRONTIER SCIENCE PROGRAM. DR. ZEITLINGER EARNED A PHD IN MOLECULAR BIOLOGY FROM THE EUROPEAN MOLECULAR BIOLOGY LABORATORY IN HEIDELBERG, GERMANY. RESEARCH FOCUS: ANALYSIS OF THE GENE REGULATORY NETWORKS UNDERLYING CELLULAR DIFFERENTIATION. TECHNOLOGY CENTERS 1. PAUL KULESA, PHD, DIRECTOR OF IMAGING, JOINED SIMR IN 2002 AFTER COMPLETING A BURROUGHS WELLCOME FUND POSTDOCTORAL FELLOWSHIP IN THE LABORATORY OF DR. SCOTT E. FRASER AT THE CALIFORNIA INSTITUTE OF TECHNOLOGY. DR. KULESA RECEIVED A PHD IN APPLIED MATHEMATICS UNDER DR. J.D. MURRAY AT THE UNIVERSITY OF WASHINGTON. RESEARCH FOCUS: CELL MIGRATION IN DEVELOPMENT AND CANCER. 2. MICHAEL WASHBURN, PHD, DIRECTOR OF PROTEOMICS, JOINED SIMR IN 2003 FROM THE TORREY MESA RESEARCH INSTITUTE IN SAN DIEGO WHERE HE WAS A SENIOR STAFF SCIENTIST IN PROTEOMICS. HE EARNED A PHD IN BIOCHEMISTRY AND ENVIRONMENTAL TOXICOLOGY FROM MICHIGAN STATE UNIVERSITY BEFORE COMPLETING A POSTDOCTORAL FELLOWSHIP WITH PROFESSOR JOHN YATES, III IN THE DEPARTMENT OF MOLECULAR BIOTECHNOLOGY AT THE UNIVERSITY OF WASHINGTON. RESEARCH FOCUS: QUANTITATIVE PROTEOMICS AND PROTEIN COMPLEX DYNAMICS. |
Attach to Form 990 or 990-EZ.