Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Federal Dept./Agency | Date |
|---|---|---|---|---|---|
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $288,854 | Grant | Trans-NIH Recovery Act Research Support: The focus of our research is to determine how signal transduction regulates directed motility and behavior in the bacterium Myxococcus xanthus using an integrated approach that combines biochemistry, genetics, and cell biology. M. xanthus is an excellent | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF CENTRAL FLORIDA | $241,774 | Grant | Trans-NIH Recovery Act Research Support: BAX is a member of the BCL-2 family that can promote cell death by making possible the release of apoptotic factors from mitochondria and the endoplasmic reticulum. Many different proteins have been identified that regulate the activity of BAX, but the co | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $59,916 | Grant | Trans-NIH Recovery Act Research Support: This application is submitted in response to NOT-OD-09-056 for an Administrative Supplement to R01 HD 059140 (Morrow, PI; Schibler, co-PI), G?Novel genetic and salivary glycan biomarkers for risk of NEC in ELBW infants.G? This grant was awarded in January | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $244,686 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this contract is to hire a post-doctoral researcher to assist in the completion of research studies focused on the role of signaling pathwasy mediating pulmonary fibrosis. Expected outcomes from this contract will include providing empoymen | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF FLORIDA | $219,927 | Grant | Trans-NIH Recovery Act Research Support: Bayesian methods for (incomplete) longitudinal cancer data We continue work from our previous proposal in developing new Bayesian methodology for longitudinal cancer data with missingness. In the presence of missing data that is related to observed or | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $298,479 | Grant | Trans-NIH Recovery Act Research Support: Cancer cell telomere dynamics and responses to perturbaturbations The parent grant analyzes telomere behavior, the consequences of telomere malfunctioning, and telomerase activation and inactivation in human cancer cells. Those Aims are: Aim 1. Analyze re | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $556,780 | Grant | Trans-NIH Recovery Act Research Support: In research studies supported by this grant, mutations was discovered in a gene called PTPN11 in pediatric and adult leukemia, which makes a protein called SHP-2. These abnormal SHP-2 proteins cause leukemia and cause developmental disorders by turning on | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| ARIZONA STATE UNIVERSITY | $268,363 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this work is to develop nano-machine technology for observing and interacting with the human body at the cellular level. The project's focus is a remotely powered and controlled artificial electrocyte (electric-organ cell) able | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF FLORIDA | $219,734 | Grant | Trans-NIH Recovery Act Research Support: This project is collaborative with Dr. Christopher Vulpe , Berkeley University, CA (P42 ES04705: project 2). Both Dr. Vulpe and the Florida team are focused on understanding the molecular mode of action of Superfund chemicals, using different approaches | Health and Human Services, Department of / National Institutes of Health | 9/06/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $393,988 | Grant | Trans-NIH Recovery Act Research Support: Our work of the 25 years has been instrumental in establishing that the spliceosome is a highly dynamic RNA-protein machine that relies on RNA-dependent ATPases to promote multiple conformational rearrangements during assembly, catalysis, and disassembly. | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| NORTHEASTERN UNIVERSITY | $641,368 | Grant | Trans-NIH Recovery Act Research Support: A Genomics Approach to Drug Tolerance | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $1,260,717 | Grant | Trans-NIH Recovery Act Research Support: Improving Self-Reports About High Risk Sexual Behavior. Research findings of sex surveys provide abundant empirical evidence that the reliability and validity of self-reported sexual behavior is a major problem, particularly when assessing behavior among | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| WAYNE STATE UNIVERSITY (INC) | $441,552 | Grant | Trans-NIH Recovery Act Research Support: We propose to use use probabilistic tractography to quantify the strength of the arcuate fasiculus, and we hypothesize that this technique can be used as a biomarker to designate children with developmental delay who unlikely to make full recovery, thus a | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $147,546 | Grant | Trans-NIH Recovery Act Research Support: The studies proposed in the parent grant are generating a resource of gene expression microarray, clinical and morphometric data. The goal of this supplement is to fund a Post-doctoral fellowship in Applied Bioinformatics for analysis of these genomic da | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $81,731 | Grant | Trans-NIH Recovery Act Research Support: In the process of identifying specific genes corresponding to specific candidate loci among large numbers of genes corresponding to broad QTL peaks. | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $849,750 | Grant | Trans-NIH Recovery Act Research Support: Demyelinating and dysmyelinating disorders include a significant number of degenerative conditions in human including Multiple Sclerosis. However, our knowledge of these processes is still limited and effective treatments for most of the demyelinating/dys | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| COLORADO STATE UNIVERSITY | $147,000 | Grant | Trans-NIH Recovery Act Research Support: We will develop controlled vocabularies (sets of standardized and defined terms) and ontologies (sets of standardized and defined controlled vocabulary terms and their inter-relationships) for vector surveillance and vector management. Use of these contro | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CENTRAL FLORIDA | $186,334 | Grant | Trans-NIH Recovery Act Research Support: We have recently shown that tyrphostin AG490 blocked phosphorylation of Stat5 via the IL-2-JAK-Stat5 signaling pathway in regulatory T-cells in NOD and B6 mice. We have also reported that weaker DNA binding affinity of Stat5B to the DNA in NOD mouse is du | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $418,458 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of this grant, RELM Peptides Alter Lung Defense, is to broadly determine immune mechanisms at respiratory mucosal surfaces to gain new insights that will facilitate vaccine development, which will protect mucosal surfaces from infectio | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $6,300 | Grant | Trans-NIH Recovery Act Research Support: The study founded by this award is to focus on defining the therapeutic effect of isofagomine (IFG), a pharmacological chap-?erone, in correcting substrate accumulation and improving the phenotype of neuronopathic variants of Gaucher disease. These resear | Health and Human Services, Department of / National Institutes of Health | 7/09/2009 |
| YALE UNIVERSITY | $455,125 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to analyze the dynamic changes that occur at a cellular and molecular level during synaptic development and plasticity. These events will be examined in a well characterized genetic model system, the Drosophila neuromuscular ju | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF DELAWARE | $401,735 | Grant | Trans-NIH Recovery Act Research Support: In the revised proposal we proposed to the following aims: Aim 1: To apply a whole plant screening method to test Enterococcus species pathogenicity. Identify plant species that reveal a tolerant phenotype in the in vitro based infections. Characterize th | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $414,427 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of the Innate Immune Response Genetics and T Cell Activation in HIV Treated HIV Infection grant is to better define the determinants of immune recovery during antiretroviral therapy in resource-limited settings in order to optimize the | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $424,336 | Grant | Trans-NIH Recovery Act Research Support: Pregnancy is often a time with increased oral health concerns, yet low rates of dental care utilization. Pregnancy is also a time when women are motivated to take better care of their health for themselves and their unborn infants; thus it is an opportune | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| ARIZONA STATE UNIVERSITY | $403,977 | Grant | Trans-NIH Recovery Act Research Support: Increased flux of free fatty acids (FFA) from adipose tissue to non-adipose tissues contributes to and augments many metabolic derangements that are characteristic of the metabolic syndrome and type 2 diabetes, including insulin resistance. Evidence indic | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| BLUE BELT TECHNOLOGIES, INC. | $295,097 | Grant | Trans-NIH Recovery Act Research Support: The proposed brain probe will permit intracranial hematomas (large blood clots on the brain) to be surgically evacuated in a minimally invasive manner in the Intensive Care Unit under a local anesthetic. This surgical treatment will be navigated and utili | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| CARNEGIE MELLON UNIVERSITY | $333,151 | Grant | Trans-NIH Recovery Act Research Support: Among the many problems arising from cell biology and medicine, shape phenotype mapping (the detailed measurement of shape related quantities from cells and subcellular organelles) from microscopy images has received particular attention in the past due t | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $475,651 | Grant | Trans-NIH Recovery Act Research Support: Our preliminary studies based on proton nuclear magnetic resonance spectroscopy (1H-NMR) show that multivariate analysis of the NMR spectra recorded for culture media samples from 100% and 0% implantation cases revealed a statistical separation of the two | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $424,874 | Grant | Trans-NIH Recovery Act Research Support: Src familyGrant name: Src family kinases-mediated ischemic neonatal brain injury Specific aims: Stroke is one of the leading causes of childhood mortality and occurs in 1 out of 4000 live births, an incidence equal to that of stroke in the elderly. H | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $424,704 | Grant | Trans-NIH Recovery Act Research Support: The project entails stereologic validation of a murine model of traumatic brain injury based upon MRI changes in brain-injured children and testing the efficacy of matrix metalloproteinase inhibitor in supporting structural recovery in the animal model. | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $142,777 | Grant | Trans-NIH Recovery Act Research Support: To determine cost offset, acceptability & utility of computerized mental health screening & treatment tracking for older, low income mentally ill patients receiving mental health care in community based mental health settings serving diverse populations. | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $140,901 | Grant | Trans-NIH Recovery Act Research Support: The parent HPV (Human Papillomavirus) grant for this supplement has resulted in numerous publications and has influenced policy and clinical management strategies which have benefited adolescents and young women. The study has collected over 100,000 speci | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $56,920 | Grant | Trans-NIH Recovery Act Research Support: This supplement provided critical salary support for two senior postdoctoral fellows, and allowed them to continue employment in the Vale lab and make transitions to full-time positions. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MOLECULAR TARGETING TECHNOLOGIES, INC. | $176,838 | Grant | Trans-NIH Recovery Act Research Support: This proposal builds on our recent discovery that squaraine rotaxanes (SRs) are among the world's brightest and most stable fluorescent NIR dyes. However due to their poor solubility under aqueous conditions, their usefulness in biological applications re | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF ILLINOIS | $763,828 | Grant | Trans-NIH Recovery Act Research Support: This project explores continuing post-developmental neurogenesis and non-neuronal cytogenesis as processes that could be harnessed to aid in rehabilitation of the fetal alcohol-damaged brain. We have found that the capacity for post-weaning cytogenesis in | Health and Human Services, Department of / National Institutes of Health | 6/26/2009 |
| AUTISM SPEAKS, INC. | $960,080 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this award is to enhance the bioinformatic infrastructure of the AGRE program and establish AGRE as a data federation site for the National Database for Autism Research (NDAR). This award leverages the substantial investments made by Autism | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| CARNEGIE MELLON UNIVERSITY | $948,648 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (01): Behavior, Behavioral Change, and Prevention, and specific Challenge Topic 03-MH-101: Biomarkers in Mental Disorders. Clinically significant depressive symptoms have been reported in up to 86% of nursin | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF ILLINOIS | $997,130 | Grant | Trans-NIH Recovery Act Research Support: An important challenge in developing treatments that induce weight loss and prevent weight regain is to identify regulatory mechanisms that can be targeted for drug therapy. Invertebrate models have commonly been used to discover new candidate genes for m | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $1,206,941 | Contract | : The funds will cover the support of clinical trials for the ACCELERATING CLINICAL TRIALS OF NOVEL ONCOLOGIC PATHWAYS (ACTNOW)Project. | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| CHILDREN'S MEMORIAL HOSPITAL, THE | $176,682 | Grant | Trans-NIH Recovery Act Research Support: The award will allow the prinicipal investigating laboratory to determine the potential use of the engineered mouse models for their utility in pre-clinical studies utilizing pharmacological agents. In addition, the award will also assist in the generati | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| RESEARCH FOUNDATION FOR MENTAL HYGIENE INC | $186,946 | Grant | Trans-NIH Recovery Act Research Support: To support research and other projects that will support fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments while also providing economic stimulus to the nation. | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| RESEARCH FOUNDATION FOR MENTAL HYGIENE INC | $386,598 | Grant | Trans-NIH Recovery Act Research Support: To support research and other projects that will support fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments while also providing economic stimulus to the nation. | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| RESEARCH FOUNDATION FOR MENTAL HYGIENE INC | $69,480 | Grant | Trans-NIH Recovery Act Research Support: To support research and other projects that will support fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments while also providing economic stimulus to the nation. | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| RESEARCH FOUNDATION FOR MENTAL HYGIENE INC | $522,364 | Grant | Trans-NIH Recovery Act Research Support: To support research and other projects that will support fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments while also providing economic stimulus to the nation. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $165,836 | Grant | Trans-NIH Recovery Act Research Support: This chemistry-biology interface predoctoral training program provides graduate Ph.D. students with rigorous training in the application of chemical principles and techniques to the investigation and modulation of biological systems. The interface between | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $70,908 | Grant | Trans-NIH Recovery Act Research Support: The UCSF Biomedical Sciences Program is an interdisciplinary predoctoral graduate research program that equips students with the training and research tools to study the function of tissue and organ systems in development, physiology, and disease. | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF ILLINOIS | $90,184 | Grant | Trans-NIH Recovery Act Research Support: The School of Chemical Sciences (SCS) at the University of Illinois proposes to implement a training program at the Chemistry - Biology interface that will enroll 10 predoctoral students per year (5 2nd yr and 5 3rd yr students). The program will, through | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $100,375 | Grant | Trans-NIH Recovery Act Research Support: Viral replication and immune evasion often require manipulation of cellular gene expression either in a targeted or global manner. Along these lines, lytic infection with the human gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV) leads to | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $0 | Grant | Trans-NIH Recovery Act Research Support: This award was relinquished prior to the start of the project. | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $410,944 | Grant | Trans-NIH Recovery Act Research Support: Purpose: The study will determine the influence of genetic risk factors on radiotherapy sensitivity among childhood cancer survivors, using the existing Childhood Cancer Survivor Study (CCSS) cohort. The Childhood Cancer Survivor Study (CCSS) is a retros | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $155,376 | Grant | Trans-NIH Recovery Act Research Support: Approximately one third of adults and up to 70% of all adolescents with severe obesity has obstructive sleep apnea (OSA). The pulmonary, cardiovascular, and cognitive consequences of this disorder are profound. Available evidence strongly supports o | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $393,399 | Grant | Trans-NIH Recovery Act Research Support: Our ARRA application (parent CPTAC project NIH/NCI U24CA126477) requested salary funds to support an additional phlebotomist. We proposed to prospectively collect and process blood samples from breast cancer patients and healthy women (controls). This add | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $888,643 | Grant | Trans-NIH Recovery Act Research Support: Title: 'Immunosuppression Withdrawal for Stable Pediatric Liver Transplant Recipients' - This is a two-year planning grant for a future multi-center, randomized clinical trial assessing the efficacy and safety of immunosuppression withdrawal for stable pe | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $466,540 | Grant | Trans-NIH Recovery Act Research Support: Biomedical informatics spans a research space essential in a number of areas of life sciences and healthcare. The demand for well-trained research scientists in this area is exploding, although there is real need for independent research and informatics t | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CARNEGIE MELLON UNIVERSITY | $297,764 | Grant | Trans-NIH Recovery Act Research Support: The goal of the NIGMS-MARC parent grant is to establish bioinformatics teaching and research on partner minority campuses through a four part program involving: - Training an interdisciplinary group of faculty at minority serving institutions in the field | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| RESEARCH FOUNDATION FOR MENTAL HYGIENE INC | $370,192 | Grant | Trans-NIH Recovery Act Research Support: To support research and other projects that will support fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments while also providing economic stimulus to the nation. | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| RESEARCH FOUNDATION FOR MENTAL HYGIENE INC | $159,681 | Grant | Trans-NIH Recovery Act Research Support: This is an administrative supplement to DCIPS: Intervention with High Suicide Risk Individuals. This supplement will permit the continued employement of key members of the research staff and more fully achieve one of the critical aims of the Center, i.e. | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| NORTHEASTERN UNIVERSITY | $199,385 | Grant | Trans-NIH Recovery Act Research Support: Nanotheraputic Strategy for multi drug resistant tumors | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $189,941 | Grant | Trans-NIH Recovery Act Research Support: Award Description: This is the final report for this award. Project is completed and two publications have been published to this date. A third manuscript is submitted. | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $135,591 | Grant | Trans-NIH Recovery Act Research Support: Biocompatible Dendritic Polymer s for in vivo Application. Overall goal of this research is to devise biodegradable polymer-drug conjugates to improve the treatment of cancer. First goal, to synthesize 100 mg drug equivalent amounts of polymer drugs tha | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| ARIZONA STATE UNIVERSITY | $228,164 | Grant | Trans-NIH Recovery Act Research Support: Research carried out in the past at Arizona State University (ASU) has identified the antimicrobial agent triclocarban (TCC) as an environmental pollutant that occurs nationwide in terrestrial and aquatic environments including a number of Superfund sites | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| ALBERT EINSTEIN COLLEGE OF MEDICINE | $580,641 | Grant | Trans-NIH Recovery Act Research Support: All Herpes viruses possess a proteinaceous layer termed tegument which lines the inner surface of their envelope. Tegument is acquired both at the inner nuclear membrane during primary envelopment, and in the cytoplasm during secondary envelopment. These | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $197,229 | Grant | Trans-NIH Recovery Act Research Support: The parent grant is based on mounting evidence that targeted inhibition of signaling molecules is an efficacious strategy for the treatment of a number of hu-?man cancers. In the parent proposal, our hypothesis is that efficient therapeutic strategies aga | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| ARIZONA STATE UNIVERSITY | $183,106 | Grant | Trans-NIH Recovery Act Research Support: This supplement funds 12 undergraduate student workers in the summer of 2009 (7 at Arizona State University; 4 at the University of Washington and 1 at Brandeis University) and 13 in the summer of 2010 (7 at Arizona State University; 4 at the University o | Health and Human Services, Department of / National Institutes of Health | 5/28/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $452,822 | Grant | Trans-NIH Recovery Act Research Support: Feedback from targeted actions like reaching is used to calibrate those actions so that they can be accurate. We propose to investigate whether calibration is a potential solution to known deficits and clumsiness suffered by the elderly and children with | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $748,047 | Grant | Trans-NIH Recovery Act Research Support: Stem cell populations in the body are surrounded by G?nichesG? of specialized cells that control stem cell behavior, including the property of pluripotency. Stem cells are released from their niches in a controlled fashion to differentiate into the specia | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| BUCK INSTITUTE FOR RESEARCH ON AGING | $970,000 | Grant | Trans-NIH Recovery Act Research Support: Dietary restriction (DR) is the most robust environmental intervention to date that results in lifespan extension in species as diverse as yeast, worms, fruit flies and rodents (Masoro, 2002). DR also slows the progression of many age-related diseases inc | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| BUCK INSTITUTE FOR RESEARCH ON AGING | $969,959 | Grant | Trans-NIH Recovery Act Research Support: In the mitochondrial free radical theory of aging, mitochondrial reactive oxygen species (ROS) generation is an inevitable consequence of oxidative ATP production, and the primary cause of macromolecular damage. Some damage is not repaired, causing progre | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER | $293,700 | Grant | Trans-NIH Recovery Act Research Support: Connexins are the proteins that form the gap-junction channels that mediate cell-to-cell permeation of ions and hydrophilic molecules, hence underlying electrical and chemical coupling between neighboring cells. Connexins are essential for embryonic devel | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $408,929 | Grant | Trans-NIH Recovery Act Research Support: Bacteria are among the simplest organisms in nature, but perform critical functions for life on earth including generating energy, recycling minerals and degrading environmental toxins. Additionally, disease-causing bacteria are a major risk to human hea | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $36,974 | Grant | Trans-NIH Recovery Act Research Support: The proposed supplement would be used to pursue analyses of the structure and content of the friendship and romantic networks of youth with physical and mental health problems. The original project proposed very basic analyses of the friendship networks o | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF MISSOURI SYSTEM | $521,831 | Grant | Trans-NIH Recovery Act Research Support: Notice Number: NOT-OD-09-058 Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications Title: Dual AAV Vectors for Duchenne Muscular Dystrophy Therapy-Competitive Revision Project Description (Abstract) | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $205,541 | Grant | Trans-NIH Recovery Act Research Support: This award is a Recovery Act Administrative Supplement, which provides supplementary funding for an ongoing NIH R01 grant (R01-GM053270-19; PI: Morgan, D.O. ; Title: Molecular Control of Cell Proliferation). Specifically, supplement funds were used to (1) | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| CARNEGIE MELLON UNIVERSITY | $510,300 | Grant | Trans-NIH Recovery Act Research Support: Information on subcellular location is critical to determining the function of unknown proteins, and high-resolution knowledge of locations for entire proteomes will be essential for systems biology approaches to copmprehensive modeling of cell behavior. | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $755,525 | Grant | Trans-NIH Recovery Act Research Support: Stephens - R01AI073792 - Final Progress Report. Specific Aims. The specific aims have not been modified from those funded as: 1) isolate and purify chlamydial inclusions, and 2) characterize inclusion membrane composition. Summary of progress toward achi | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $760,625 | Grant | Trans-NIH Recovery Act Research Support: The protozoan parasite Toxoplasma gondii causes life-threatening disease in immunocompromised individuals. While effective at controlling acute disease, available drugs fail to clear chronic, latent infection with T. gondii. An in-depth understanding of t | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $202,264 | Grant | Trans-NIH Recovery Act Research Support: This proposed CSS administrative supplement to parent grant R01 DC007325-05 would support the continuing employment of a senior Ph.D. scientist in the laboratory. The scientist's research focuses on the molecular characterization of neural progenitor cell | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $7,500 | Grant | Trans-NIH Recovery Act Research Support: This study founded by this award provides a summer research opportunity for an undergraduate student that will engage the interest in biomedical science. The study addresses the following hypotheses: 1) Prototype competitive inhibitors, termed pharmacolog | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $30,000 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the supplement is to encourage and motivate students into the field of medical research. Therefore, the principal investigator (PI) submitted administrative supplement in view of the NIH notice (NOT-OD-060) to obtain additional funds to re | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $213,494 | Grant | Trans-NIH Recovery Act Research Support: The overall design of the study is a Randomized Cluster Control Trial to examine the effects of the Non-pneumatic Anti-shock Garment (NASG) as a first-aid device for obstetric hemorrhage at the District Clinics (clinics) in Zambia and Zimbabwe. | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $258,800 | Grant | Trans-NIH Recovery Act Research Support: This research project studies opportunistic pneumonias in HIV-infected persons and explores factors associated with mortality from Pneumocystis pneumonia (PCP), a leading AIDS-defining pneumonia and cause of death. | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $486,922 | Grant | Trans-NIH Recovery Act Research Support: Moving a Science-Based Intervention Into Practice. The Mpowerment Project (MP) is an evidence-based HIV-prevention program for young gay/bisexual men. In the original research trials, the MP reached few Black men. We are adapting the MP to their needs bec | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $336,367 | Grant | Trans-NIH Recovery Act Research Support: Attention Deficit Hyperactivity Disorder, Predominantly Inattentive Type (ADHD-I) is a prevalent and serious childhood psychiatric disorder, adversely impacting a child's functioning at school, at home, and with peers. This study provides for a study of c | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $224,040 | Grant | Trans-NIH Recovery Act Research Support: We have completed the hypoxia-ischemia experiments on hybrid GPx over-expressors x IF-knock-out pups. Since oxidative stress initiates hypoxic-ischemic brain injury and the neonatal brain may be particularly vulnerable to this stress, we have previously s | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $182,715 | Grant | Trans-NIH Recovery Act Research Support: Project Abstract: The neuromuscular junction of Drosophila is highly homologous to the mammalian neuromuscular junction and is amenable to powerful forward genetic screening that is not possible in vertebrates. Forward genetic approaches in Drosophila can | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $833,493 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project is to use advanced magnetic resonance imaging (MRI) to understand mechanisms leading to neurodevelopmental impairment in critically ill newborns with congenital heart disease (CHD). Research studies have determined that i | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| OCCIDENTAL COLLEGE | $192,048 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The goal of this AREA proposal is to identify the arsenal of peptides the fish- hunting cone snail, Conus catus utilizes to subdue its prey through the rapid modulation of spinal motor activity. A prominent neuroexcita | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $995,504 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic, 06-ES-102* 3-D or virtual models to reduce use of animals in research: Creation of miniature multi-cellular organs for high throughput screening for c | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $409,805 | Grant | Trans-NIH Recovery Act Research Support: Myopia (shortsightedness) This project explores a novel approach to the prevention and treatment of myopia (near-sightedness), which involves excessive elongation of the eye due to remodelling in the sclera, the outer supporting wall of the eye. Recent ye | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| ARIZONA STATE UNIVERSITY | $115,141 | Grant | Trans-NIH Recovery Act Research Support: The current supplemental project will complement the parent project by extending the context of our investigation outside the controlled environment of the laboratory to the natural environment of everyday experience. We propose to use online twice-daily | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| UNIVERSITY OF FLORIDA | $402,875 | Grant | Trans-NIH Recovery Act Research Support: The aim of the present research is to assess attention capture, sustained attention, and defensive reflex engagement during emotional perception in anxiety patients diagnosed with and without co-morbid major depression, and in healthy control participants | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $424,875 | Grant | Trans-NIH Recovery Act Research Support: Title: EGFR TARGETING OF THERAPEUTIC LIPOSOMES FOR TREATING GLIOBASTOMA; Purpose and goals: This project is for comparing epidermal growth factor receptor (EGFR) targeted liposome-formulated topotecan (EGFR-LFT) vs. non-targeted liposome-formulated topo | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $121,244 | Grant | Trans-NIH Recovery Act Research Support: As the number of minorities in the population continues to increase, the health disparities for these groups will likely intensify. Underrepresented health care providers are therefore critical to the reduction in these disparities. Programs are thus nee | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $108,000 | Grant | Trans-NIH Recovery Act Research Support: Multidisciplinary Area of Concentration Program in Global Health. The activities for the ARRA supplement include an information and communication technologies (ICT) component to be added to our present University of California San Francisco (UCSF) - Unive | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $307,209 | Grant | Trans-NIH Recovery Act Research Support: In research studies supported by this grant, we discovered mutations in a gene called PTPN11 in pediatric and adult leukemia, which makes a protein called SHP-2. These abnormal SHP-2 proteins cause leukemia and cause developmental disorders by turning on | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $285,546 | Grant | Trans-NIH Recovery Act Research Support: T brucei cells r synchronized&released for synchronous cell cycle progression. Inhibitor of T brucei Aurora B kinase r added @ different times.2 distinctive actions of Aurora B r demostrated; transition of metaphase to anaphase&initiation of cytokinesis | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| ALLEN INSTITUTE FOR BRAIN SCIENCE, THE | $8,326,141 | Grant | Trans-NIH Recovery Act Research Support: The goal of the current Grand Opportunity is to create a unique, multimodal transcriptional atlas of the pre- and postnatal developing human brain. This new and unique data-rich resource will integrate transcriptomic, cellular resolution histology and im | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| ALBERT EINSTEIN COLLEGE OF MEDICINE | $400,000 | Grant | Trans-NIH Recovery Act Research Support: This supplemental Pilot and Collaborative Grant initiative supports the overall vision of the CTSA, and provides resources needed to successfully achieve some of the goals outlined in our initial proposal. It provides and important collaborative link bet | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| YESHIVA UNIVERSITY | $600,000 | Grant | Trans-NIH Recovery Act Research Support: Bronx Community Research Review Board: Evaluation of an Innovation Model for Community-based Research Consultation & Review (Date of award: 9/3/09) Aim 1. With the Bronx Health Link collaboratively develop an independent Bronx Community Research Review | Health and Human Services, Department of / National Institutes of Health | 9/06/2009 |
| ARIZONA STATE UNIVERSITY | $418,785 | Grant | Trans-NIH Recovery Act Research Support: Multiphoton excitation (MPE) microscopy has become a powerful optical tool in investigating neuronal structure and function in intact brain circuits. Arizona State University has recently made neuroscience a major research initiative in creating an interd | Health and Human Services, Department of / National Institutes of Health | 4/27/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $772,500 | Grant | Trans-NIH Recovery Act Research Support: We have successfully identified and recruited junior faculty member of the caliber of Xiaokun Shu to be part of the Chemical Biology group. Currently, Dr. Shu has 1 person in his lab, (Post Doc) . Furthermore, Dr. Shu has begun setting up his lab. The lon | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $600,000 | Grant | Trans-NIH Recovery Act Research Support: HARC Center: HIV Accessory and Regulatory Complexes Viral-host complexes play an integral role in HIV biology. The HARC Center focuses on complexes involved in transmitting the viral genetic information during infection. Three major projects involve HIV | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| ARIZONA STATE UNIVERSITY | $910,150 | Grant | Trans-NIH Recovery Act Research Support: The supplement award will accelerate our studies of cell-cell interactions using the breakthrough cell analysis technologies developed, validated and currently exploited in our laboratory for single-cell physiological and transcriptomic studies. Cell-cel | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $754,777 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of our research is to understand and manipulate immune surveillance. The antigen processing mechanisms yields thousands of peptide/MHC class I complexes (pMHC I) on the cell surface as potential ligands for CD8 T cells. Contrary to text | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $741,794 | Grant | Trans-NIH Recovery Act Research Support: Hematopoietic as well as leukemic stem cells (HSC/LSC) are dependent on interactions with extracellular matrix, soluble factors and cellular components of the bone marrow (BM) microenvironment for their survival. These interactions are hypothesized to pro | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $115,345 | Grant | Trans-NIH Recovery Act Research Support: This grant supplements work on an R01 award on mechanotransduction in fibroblasts to support personnel who will determine how mechanical force promotes actin filament and focal adhesion remodeling in live cells. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| IOWA STATE UNIVERSITY | $450,433 | Grant | Trans-NIH Recovery Act Research Support: This award is a supplement to award GM07966301. Post-translational histone modifications are essential to the proper regulation of nearly all DNA-mediated processes, whereas improper modifications lead to numerous disease states. Histone modifications e | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $99,372 | Grant | Trans-NIH Recovery Act Research Support: This supplement is to purchase a high-tilt and high-resolution cryo-specimen holder equipment and a carbon evaporator equipment to carry out cryoEM experiments proposed in the parent grant. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $99,999 | Grant | Trans-NIH Recovery Act Research Support: In this supplement, we propose to set up a bioassay for CCK and measure CCK levels in human subjects given bile acide supplements; CCK is the hormone responsible for gallbladder contraction. There is no reliable assay for CCK that is sensitive enough to | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $700,000 | Grant | Trans-NIH Recovery Act Research Support: Focal Segmental Glomerulosclerosis (FSGS) is a heterogeneous and devastating disease that is one of the major causes of renal failure. The long term goals of the research project are to provide a deeper understanding of this disease, to identify novel th | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| BURNHAM INSTITUTE FOR MEDICAL RESEARCH | $955,000 | Grant | Trans-NIH Recovery Act Research Support: Specific Aim 1: Determination of functional structure of KS-GAG for corneal ECM organization. We created mutant mice lacking a carbohydrate sulfotransferase that is required for KS sulfation and found that the mutant mice show thinner stromal region and | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $1,091,071 | Grant | Trans-NIH Recovery Act Research Support: This award addresses an important concern for women's health, i.e. infertility. Despite significant developments in IVF technology, the pregnancy success rate remains low because of higher incidence of implantation failure and unexplained pregnancy loss. | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $225,351 | Grant | Trans-NIH Recovery Act Research Support: A link between tumor cell-associated procoagulant function (i.e., tissue factor expression) and tumor dissemination is well established. However, the mechanistic details are not fully defined. We have previously shown that tumor cell-associated tissue f | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $15,000 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this contract is to hire a summer research student to assist in the performance of research stuides focused on the role of signaling pathways mediating pulmonary fibrosis. Expected outcomes from this contract include summer employment, int | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF DELAWARE | $146,983 | Grant | Trans-NIH Recovery Act Research Support: Recovery Act Funds for Administrative Supplements for Structure and Function of the SV40 Large Tumor Antigen This funding will be used to maintain the present tempo of the funded project. At this time, we are working on a no-cost extension past the one | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $307,206 | Grant | Trans-NIH Recovery Act Research Support: Goals and Project Purpose: This supplement funds a post-doctoral scholar and a pre-doctoral research assistant for the purpose of accelerating and enhancing the tempo and productivity of the current project. The goals of the parent are to develop and appl | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| COLORADO STATE UNIVERSITY | $652,948 | Grant | Trans-NIH Recovery Act Research Support: The primary focus of this application is to study the total synthesis and biosynthesis of complex, biomedically significant natural products constituted of tetrahydroisoquinolines. The synthetic chemistry that will be developed shall be utilized to prepar | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $683,617 | Grant | Trans-NIH Recovery Act Research Support: This grant (5R01CA134622) funds experiments techniques using ground-breaking microscopy techniques to directly examine immune cells within breast tumors. The study examines T cells of the immune system and is examining, at a very fine detail, how the imm | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| ARIZONA STATE UNIVERSITY | $184,568 | Grant | Trans-NIH Recovery Act Research Support: The first purpose of the supplement is to accelerate our productivity. Despite our excellent progress, it will not be possible to complete the five years of proposed experiments in only three years with the current level of funding, and thus not possible | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $765,887 | Grant | Trans-NIH Recovery Act Research Support: This ARRA R01 project, entitled Specification and development of ciliary body and anterior eye epithelium, seeks to provide better basic understanding of early eye development, particularly of the anterior portion of the eye, and to link genetic informati | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $366,127 | Grant | Trans-NIH Recovery Act Research Support: Dry eye is a common pathology in autoimmune disease. Chronic dryness can provoke squamous metaplasia (SQM) of the ocular surface where keratinization and opacification of the cornea can cause blindness. Using the autoimmune regulator (Aire) knockout (KO) | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $78,129 | Grant | Trans-NIH Recovery Act Research Support: This is an equipment award that will accelerate the studies on a novel model of uveitis and serve the broader community of scientists in the Anderson Lab, the UCSF Diabetes Center, and the Immunology Community. | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| CARNEGIE MELLON UNIVERSITY | $57,803 | Grant | Trans-NIH Recovery Act Research Support: The ultimate goal of our research supported by R01GM084614 (?Biophysical & Molecular Biological Studies of Hemoglobin?) is to provide a detailed structural and dynamic description of how O2 binding to one subunit of the hemoglobin (Hb) molecule can alter | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF MARYLAND | $80,047 | Grant | Trans-NIH Recovery Act Research Support: This project focuses on the roles of hyaluronidase-1 (hHyal-1) and hyaluronidase-2 (hHyal-2) in the mediation of the biological functions assumed by the extracellular matrix polysaccharide hyaluronan (HA). HA serves as the ?glue? that binds cells together | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CARNEGIE MELLON UNIVERSITY | $363,774 | Grant | Trans-NIH Recovery Act Research Support: This supplement is being used to support an additional full-time investigator, Dr. Alberto Gandini, who possesses particular skills and expertise not currently available in our group. The current team is comprised primarily of biomedical engineers, life s | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $953,091 | Grant | Trans-NIH Recovery Act Research Support: R01 HL090662-01A2 (Role of Squamous Metaplasia in Small Airways Disease in COPD): Chronic obstructive pulmonary disease is a devastating disease, which is a major cause of mortality and morbidity worldwide. Currently, there are no effective therapies to t | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $323,402 | Grant | Trans-NIH Recovery Act Research Support: R01MH080283-03S1 Dynamic Analysis of Neural Plasticity in the Hippocampal Circuit. The purpose of this grant is to understand the role of awake memory replay in learning and memory. We found that as animals learn about a new place there is frequent awake | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $23,234 | Grant | Trans-NIH Recovery Act Research Support: To study the effector function of natural killer T (NKT) cells in sarcoidosis. | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF DELAWARE | $153,000 | Grant | Trans-NIH Recovery Act Research Support: In the original proposal we proposed to the following aims: Aim 1: To apply a simple root screening method to test E. faecalis and E. faecium pathogenicity. Identify plant species that resist infection by E. faecalis and E. faecium and collect their root | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $154,500 | Grant | Trans-NIH Recovery Act Research Support: Project was completed as of 5/31/11. Final award description and progress report were reported in the last reporting period Apr-Jun 2011. | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $154,500 | Grant | Trans-NIH Recovery Act Research Support: This is the Final Report. This project is complete. The FFR has been transmitted to the sponsor. Scanned copies of the closeout documents are being emailed to [email protected]. | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $418,229 | Grant | Trans-NIH Recovery Act Research Support: Familial hemophagocytic lymphohistiocytosis (FHLH) is an autosomal recessive disease of immunoregulation. FHLH results from pathologic mutations in several genes that affect critical pathways regulating the function of NK and cytotoxic T cells (CTLs). Th | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $144,411 | Grant | Trans-NIH Recovery Act Research Support: In our parent proposal, we provided data to support the central hypothesis that PMLG??NB play a central role in HSV pathogenesis as a critical environmental modifier in neurons. We will test this hypothesis in the following Specific Aims: Aim 1: Determin | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $412,500 | Grant | Trans-NIH Recovery Act Research Support: Osteoporosis is a major public health problem affecting over 10 million adults, primarily women. A key contributor to osteoporosis prevention is optimizing accrual of peak bone mass. Adolescence is a dynamic period for bond mass development as nearly 50 | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| CHESTNUT HEALTH SYSTEMS, INC. | $369,875 | Grant | Trans-NIH Recovery Act Research Support: Comprehensive and standardized biopsychosocial assessments are a key piece of infrastructure in the drive towards evidence-based and effective substance abuse treatment. Demands to cover more areas and constructs mean that such assessments can take 1-2 ho | Health and Human Services, Department of / National Institutes of Health | 5/01/2009 |
| UNIVERSITY OF DELAWARE | $408,295 | Grant | Trans-NIH Recovery Act Research Support: ROBOT-ASSISTED MOBILITY FOR INFANTS WITH SEVERE SPINA SPINA This study will be the first to quantify the effect of intensive power wheelchair training on special needs infants with any diagnosis. Specifically, we will quantify the effect of training on t | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF DELAWARE | $396,068 | Grant | Trans-NIH Recovery Act Research Support: Analysis of Differential Resistance Emergence Risk for Differential Treatment Application Schedules This project will develop model-based approaches to therapy switching for HIV which minimize the risk of subsequent treatment failures by simultaneously | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $345,954 | Grant | Trans-NIH Recovery Act Research Support: Undercarboxylated osteocalcin, body fat, and diabetes in older adults. This study promises to break new ground by assessing evidence that the bone product, undercarboxylated osteocalcin, has an effect on insulin sensitivity, body fat, and the development | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $467,500 | Grant | Trans-NIH Recovery Act Research Support: The overt symptoms and deficits of schizophrenia (SZ) typically begin to emerge during late adolescence and early adulthood, followed by a period of post-onset functional deterioration. This peri-onset period temporally coincides with the final maturation | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $424,875 | Grant | Trans-NIH Recovery Act Research Support: Autism-specific mutation in DACT1: Impact on brain development in a mouse model-We are using a novel conditional knock-out mouse line plus neurons in primary culture to test whether a rare variant in the DACT1 locus contributes to the etiology of autism b | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| CALDERA PHARMACEUTICALS, INC. | $178,915 | Grant | Trans-NIH Recovery Act Research Support: Caldera Pharmaceuticals will complete the necessary steps to commercialize its XRflo system. In Phase I we demonstrated the feasibility of this technique to measure unlabeled protein interactions in a fluidic system. XRflo allows for real-time, direct, la | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| INNOVATIVE BIOTHERAPIES, INC. | $10,130 | Grant | Trans-NIH Recovery Act Research Support: Successful application of enhanced propagation techniques to human renal epithelial cells (REC) will provide the biomass for the manufacture of a significantly larger number of biotherapeutic renal support devices for treatment of acute renal failure (ARF | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $355,315 | Grant | Trans-NIH Recovery Act Research Support: This grant provided funds for studies on the signal transduction pathways that allow for tuberculosis bacteria to coordinate the expression of virulence factors upon infection of the host. | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $424,875 | Grant | Trans-NIH Recovery Act Research Support: We have manufactured several peptides from LINE and HERV sequences and tested PBMC from several long term non progressors (LTNPs) and several rapid progressors. The LTNPs had more responses to HERV and LINE peptides thant the rapid progressors. | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Juvenile idiopathic arthritis (JIA) is the most common autoimmune rheumatic disease of childhood. JIA is a disabling disease representing a series of childhood arthropathies that are defined based largely on clinical features. For the past thirty years, | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $836,262 | Grant | Trans-NIH Recovery Act Research Support: This Challenge Research project will undertake 1) a mouse genome-wide shRNA library screen to identify genes and associated gene networks inducing or inhibiting goblet cell differentiation and mucous hypersecretion, and 2) an extensive small molecule comp | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $996,825 | Grant | Trans-NIH Recovery Act Research Support: The title of grant # RC1 HL099820 is Novel reagents for alveolar type I and type II cells. The goals of the project are twofold. 1) To generate transgenic animals that can be used for conditional knockouts specifically in alveolar epithelial type I or ty | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $2,999,576 | Grant | Trans-NIH Recovery Act Research Support: Develop and test virus constructs for reliable and selective expression of light-activated ion channels across species; develop and test technology for the precise control of in-vivo activation of these channels in behaving animals. | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF ILLINOIS | $398,548 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of the proposed partnership is to develop, unify, refine and implement a new approach to quantitative ultrasound (QUS) imaging of biological tissues and mammary tumors by the quantification of tissue microstructure. In lay terms, if th | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF ILLINOIS | $343,845 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposed project is to develop a new technique that allows controlled formulation of docetaxel- polylactide nanoparticles containing aptamer targeting ligands that can be used for in vivo targeting of Prostate Specific Membrane Antigen fo | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ILLINOIS | $756,183 | Grant | Trans-NIH Recovery Act Research Support: African-Americans are at greater risk than Caucasians for developing hypertension, cardiovascular disease, stroke and renal disease. This is likely related to arterial dysfunction including greater arterial stiffness, and reduced microvascular reactivity | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| RESEARCH FOUNDATION FOR MENTAL HYGIENE INC | $225,750 | Grant | Trans-NIH Recovery Act Research Support: Nathan Kline Institute for Psychiatric Research (NKI) conducts a broad array of research, including basic and clinical studies of the causes of major mental illnesses and the evaluation of treatments. NKI's Laboratory Animal Resource has expanded rapidly | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| RESEARCH FOUNDATION FOR MENTAL HYGIENE INC | $500,000 | Grant | Trans-NIH Recovery Act Research Support: This project supports renovation of the animal care facility of the New York State Psychiatric Institute. The goals are 1) improve and increase housing and testing space for rodents by creating a barrier facility within which all housing and testing of m | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF MISSOURI SYSTEM | $362,860 | Grant | Trans-NIH Recovery Act Research Support: Germplasm cryobanking is an effective way of preserving scientifically, medically, economically and environmentally important genetic stocks indefinitely. Although rats are important system for modeling human disease, there is no established germplasm cry | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| CHILDREN'S MEMORIAL HOSPITAL, THE | $478,020 | Grant | Trans-NIH Recovery Act Research Support: Collaborative Grants for NCI-APRC Supplemental Support: Relationship of the ARRA Supplement Request to the Parent Grant: The parent grant focuses on the novel finding reported by the Hendrix laboratory (in Nature Medicine and PNAS) demonstrating that the | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $2,839,825 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer is one of the leading causes of morbidity and mortality among men. At the moment, we do not understand the underlying etiology, or why different groups, such as African Americans, have higher rates of disease. Risk factors for prostate can | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $930,342 | Grant | Trans-NIH Recovery Act Research Support: Eosinophilic esophagitis (EE) is an emerging worldwide disease that mimics gastroesophageal reflux disease (GERD) and can lead to esophageal narrowing and stricture (1-4). EE is differentiated from GERD by the magnitude of mucosal eosinophilia and epithe | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $677,883 | Grant | Trans-NIH Recovery Act Research Support: The grant name is Mechanisms of Initiation and Persistence of Allergic Asthma. This award facilitates studies of the mechanisms of asthma and allergies. The goals of the project are to enhance the processing of human and mouse airway tissue, to develop ef | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| CHARLES DREW UNIVERSITY OF MEDICINE AND SCIENCE | $882,110 | Grant | Trans-NIH Recovery Act Research Support: This telemedicine translational recovery administrative supplement to the Charles Drew University of Medicine and Science (CDU) Clinical Research Center parent grant seeks to build on the grant's goal of increasing community collaborations. Specifically, | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| CHILDREN'S MEMORIAL HOSPITAL, THE | $44,717 | Grant | Trans-NIH Recovery Act Research Support: There were two goals of the requested supplementary funding. The first was to augment our research group to speed up the realization of the parent grant goals. The second was to provide opportunities for a student and a faculty member from a nearby teach | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| ALBERT EINSTEIN COLLEGE OF MEDICINE | $99,729 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Currently, whole liver transplantation is the primary method used to treat end stage chronic liver failure. With the marked shortage of available donor livers, there has been considerable interest in identifying stem o | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF MIAMI | $54,910 | Grant | Trans-NIH Recovery Act Research Support: Low back pain is a major socio-economic concern in the United States. While the exact cause of low back pain is not clear, it is believed that degeneration of the intervertebral discs (IVD) of the spine is the main etiologic factor leading to the onset o | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $999,749 | Grant | Trans-NIH Recovery Act Research Support: One form of frontotemporal dementia (FTD) is frequently caused by nonsense mutations in a presumed signaling protein, Progranulin (GRN). This project aims to develop and perform preclinical testing of a combinatorial drug treatment approach that aims at r | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $841,557 | Grant | Trans-NIH Recovery Act Research Support: This is an ARRA award entitled ?Supraresolution 2-photon microscopy in brain tissue? with a challenge topic #6 ?Enabling Technologies? and subtopic 06-NS-103 ?Breakthrough technologies for neuroscience?. There are currently no supraresolution imaging meth | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $1,656,764 | Grant | Trans-NIH Recovery Act Research Support: We propose to develop a novel PET biomarker, [1-11C]Arachidonic Acid (AA) for the regional estimation of brain inflammation. Inflammation a well known feature of Alzheimer's disease (AD), is associated with amyloid plaques, neurofibrillary pathology, and | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| BAYLOR COLLEGE OF MEDICINE | $2,482,348 | Grant | Trans-NIH Recovery Act Research Support: Alterations in the epigenome have been shown to be a layer of regulation of gene expression in development and differentiation. Both chromatin modifications and DNA methylation are important in these processes. Relatively little is known about these cha | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| RAND CORPORATION. THE | $2,011,105 | Grant | Trans-NIH Recovery Act Research Support: Since 2007, we have been building a resource that facilitates the use of harmonized multi-country data sets, including the 2002 G?? 2008 waves of the Health and Retirement Study (HRS) as well as the English Longitudinal Study of Ageing (ELSA), the Survey | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| NATIONAL BUREAU OF ECONOMIC RESEARCH, INC. | $11,476,770 | Grant | Trans-NIH Recovery Act Research Support: Understanding the consequences of health insurance coverage is central to evaluating proposals to expand or modify health insurance coverage in the U.S. It also has important long-run fiscal implications for Medicare. Yet there is remarkably little convi | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $1,650,008 | Grant | Trans-NIH Recovery Act Research Support: Little is known regarding how conditions during pregnancy and early life may impact epigenetic alterations and aging processes that could subsequently manifest in midlife as atherosclerosis, type 2 diabetes, adiposity and cognitive decline. In particular, | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $2,759,411 | Grant | Trans-NIH Recovery Act Research Support: TRANSCRIPTOME AND EPIGENOME ANALYSIS OF HELPER T CELL SPECIFICATION AND PLASTICIT | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| DUKE UNIVERSITY | $3,996,278 | Grant | Trans-NIH Recovery Act Research Support: Vexing questions in the field of genomic biomarkers are: How do we build the evidence to support their clinical use? And what is their clinical value? The objective of this proposal is to develop an innovative framework for clinical effectiveness research | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $1,302,049 | Grant | Trans-NIH Recovery Act Research Support: The name of the grant is Bay Area Breast Cancer & Environment Research Center (BCERC). The purpose of the grant is to provide transdisciplinary center study of environmental determinants of puberty in young girls and pathways through early development of | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $1,558,189 | Grant | Trans-NIH Recovery Act Research Support: The Epilepsy Phenome/Genome Project is investigating how genes influence the phenotypes of common and rare epilepsies and has proposed to accelerate collection of phenotypic information by hiring a research assistant at each clinical center. | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $12,424,539 | Grant | Trans-NIH Recovery Act Research Support: Grant name: POINT. The purpose of the Platelet-Oriented Inhibition in New TIA and minor ischemic stroke (POINT) Trial is to determine the safety and effectiveness of the combination of low-dose aspirin and a medication called clopidogrel (also known by th | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $2,483,108 | Grant | Trans-NIH Recovery Act Research Support: The title of this award is Primary Immune Deficiency Treatment Consortium (PIDTC). Primary immune deficiencies (PIDs) are rare, life-threatening inherited defects in the immune system. Specific goals are to characterize the long term outcomes and late ef | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $70,098 | Grant | Trans-NIH Recovery Act Research Support: Chlamydia trachomatis has a significant impact on human health worldwide. Chlamydial STD is the most common reportable disease while Trachoma accounts for the leading cause of infectious blindness. Studies on Chlamydia are hampered by its demands as an ob | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $64,212 | Grant | Trans-NIH Recovery Act Research Support: ARRA Supplement to 3T32GM008396-18S1 A group of 34 outstanding investigators from three departments (Biochemistry, Biological Sciences and Molecular Microbiology and Immunology) at the University of Missouri propose to continue developing an interdiscipli | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| ALBERT EINSTEIN COLLEGE OF MEDICINE | $100,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The goal of this Program Project, entitled Protein Dynamics in Enzymatic Catalysis, is to study atomic motion in enzymes. We propose to study concepts of how the dynamical nature of proteins affects enzymic function an | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| ALBERT EINSTEIN COLLEGE OF MEDICINE | $121,293 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The major goal of this project is to determine the basic functional mechanism of cytochrome c oxidase (CcO), the terminal enzyme in the electron transfer chain. CcO is membrane-bound and has the dual function of reduci | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Peripheral arterial disease (PAD) occurs in 3-10% of the general population and increases to 10-15% in persons over 70 years. Advancements in endovascular therapies for PAD are limited by the lack of a suitable, biocompatible surface for the covering of | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $998,638 | Grant | Trans-NIH Recovery Act Research Support: Although attention deficit/hyperactivity disorder affects a significant number of children and adults, and despite a great deal of research in this field, the underlying biology remains poorly understood. In this proposal, we plan to combine cutting edge | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| YALE UNIVERSITY | $4,207,355 | Grant | Trans-NIH Recovery Act Research Support: Genomewide association study of cocaine dependence in two populations Abstract: Cocaine dependence (CD) is highly costly to society; genetic epidemiologic studies support moderate heritability for this trait. We have completed a genomewide linkage study | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY | $2,745,304 | Grant | Trans-NIH Recovery Act Research Support: Toward a PROSPER State Partnership Network: Building Infrastructure and Capacity The problem addressed is the lack of well-integrated infrastructure across public education systems to support sustained, quality implementation of evidence-based interventi | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,859,430 | Grant | Trans-NIH Recovery Act Research Support: A Natural Experiment of College-Ready Programs on Health Among Low SES Minorities In this proposed study, we will take advantage of a natural experiment and examine the impact of a new education model on adolescent health and health behaviors. The Los A | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF ILLINOIS | $150,000 | Grant | Trans-NIH Recovery Act Research Support: The focus of this proposal is the muscle nicotinic acetylcholine receptor (AChR), the neurotransmitter-gated ion channel that mediates fast synaptic transmission at the vertebrate neuromuscular junction (NMJ). The broad objective of this proposal is to un | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| BLOODCENTER OF WISCONSIN, INC. | $448,250 | Grant | Trans-NIH Recovery Act Research Support: The goal of this application is to purify and identify the protein responsible for the neuronal damage such that it can be investigated as a new therapeutic target for the treatment of neurodegenerative diseases, such as MS, in subsequent studies. | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $470,438 | Grant | Trans-NIH Recovery Act Research Support: In the present grant, we propose to test the hypothesis that an excitatory/inhibitory balance drives a complex epigenetic state of gene translation and repression in an activity-dependent manner during critical periods of heightened cortical plasticity in | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| MICHIGAN TECHNOLOGICAL UNIVERSITY | $165,513 | Grant | Trans-NIH Recovery Act Research Support: The goal of this study is to develop new technology to reduce secondary injury following spinal cord injury. Currently, there are no viable treatments for patients who have sustained spinal cord injury. Clinically, interventions involve injection of agent | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $412,500 | Grant | Trans-NIH Recovery Act Research Support: The objective of this proposal is to produce a panel of stable conformational isomers of human a- synuclein (aSyn) for use as immunogens to develop immunotherapy of Parkinson disease (PD). Human a-Synuclein (a-Syn) is a recognized protein marker for the p | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF UTAH, THE | $393,170 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Neurological disorders represent a rapidly growing health burden on a global scale. In the United States there are approximately 7M people suffering from Alzheimer's, Parkinson's, multiple sclerosis, amyotrophic latera | Health and Human Services, Department of / National Institutes of Health | 7/25/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $420,500 | Grant | Trans-NIH Recovery Act Research Support: We will test the overall hypothesis of this proposal that these sites are crucial to neuronal function and plasticity as mediated by ProDKs acting on native BK channels. In aim 1 we will accomplish this by examining the effects of interventions that alter | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $479,460 | Grant | Trans-NIH Recovery Act Research Support: The long term goals of this project are to understand how torsinA, the product of the DYT1 gene, regulates neurogenesis and neuronal migration in the developing brain. TorsinA is a member of the AAA+ superfamily of proteins that typically mediate conforma | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $433,125 | Grant | Trans-NIH Recovery Act Research Support: The health relatedness of this project is that by completion of our aim we will ensure clearer understanding of the molecular and functional patho physiology of limb girdle muscular dystrophy Type 2B (LGMD2B) as well as facilitate preclinical development | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| WAKE FOREST UNIVERSITY | $405,903 | Grant | Trans-NIH Recovery Act Research Support: High grade malignant gliomas are the leading cause of primary brain cancer deaths, afflicting close to 20,000 patients annually in the United States alone. Targeting tumor-specific molecular biomarkers offers the potential to deliver large amounts of ther | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF OKLAHOMA | $251,428 | Grant | Trans-NIH Recovery Act Research Support: The specific capacity-building aim is to: Strengthen and expand existing collaborations among investigators from the College of Public Health (COPH), University of Oklahoma Health Sciences Center (OUHSC) in the USA, the Walter Sisulu University (WSU) and | Health and Human Services, Department of / National Institutes of Health | 5/25/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $736,120 | Grant | Trans-NIH Recovery Act Research Support: The economical sequencing of a number of individual human genomes has been made possible by next-generation sequencing (NGS) methods. These same sequencing methods are now being applied to gene expression profiling. However, next-generation methods, when | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF MIAMI | $1,510,121 | Grant | Trans-NIH Recovery Act Research Support: Increasingly large and diverse data sets are being generated by publicly funded screening centers using various high- and low-throughput screening technologies. Much of this data is accessible. The largest public repository of small molecule screening r | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $1,491,339 | Grant | Trans-NIH Recovery Act Research Support: We propose to investigate and develop a unique Cloud computing research infrastructure that will have a very large impact on several different life science research areas. Our focus is on the large-scale, data-parallel analysis problems that result from t | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,251,292 | Grant | Trans-NIH Recovery Act Research Support: We submit this proposal in response to RFA-OD-09-004 'Grand Opportunities (GO)' and NHLBI requests for applications to one of its 9 selected high-priority topics, 'Characterizing Differentiated Heart, Lung, and Blood Cells Derived by Reprogramming Human E | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| DUKE UNIVERSITY | $3,198,204 | Grant | Trans-NIH Recovery Act Research Support: This Grand Opportunity (RC2) grant is written in response to NHLBI call for proposals on Large-scale DNA Sequencing and Molecular Profiling of Well-phenotyped NHLBI Cohorts and the addendum portion describing Molecular Profiling. The identification of mol | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| BLOOD SYSTEMS, INC. | $2,118,432 | Grant | Trans-NIH Recovery Act Research Support: There is increasing concern over the impact of global arbovirus epidemics on blood safety. This research program will address the blood safety implications of Dengue and WNV, two of the most important arboviruses, and further guide development of rationa | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $7,967,526 | Grant | Trans-NIH Recovery Act Research Support: The NHLBI portfolio of genetic association studies does not currently include a large, well characterized study of South Asians, even though the burden of coronary heart disease (CHD) among South Asians is high and rapidly increasing. We propose that the | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $3,156,731 | Grant | Trans-NIH Recovery Act Research Support: Nurses represent the single largest group of health professionals that delivers hospital care, yet little is known about what nurses do within a system context to ensure that care is safe, beneficial, patient-centered, timely, efficient and equitable. Qua | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $1,265,200 | Grant | Trans-NIH Recovery Act Research Support: Cerebral blood vessels play a key role in the pathophysiology of stroke. We all 'know' that brain blood vessels are likely to be different from vessels in other organs. For example, brain blood vessels have unique tight junctions that contribute to the bl | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| DUKE UNIVERSITY | $2,000,025 | Grant | Trans-NIH Recovery Act Research Support: This application is in response to RFA-OD-09-004, 'GO' grants program area: ARRA Medical Sequencing Discovery Projects. Despite clear evidence for the importance of genetics in susceptibility to epilepsy, only limited progress has been made in identifying | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $1,997,959 | Grant | Trans-NIH Recovery Act Research Support: This proposal requests funding to support a new, state-of-the-art, high performance storage area network (SAN) for high speed and robust access to large quantities of structural and functional imaging data. Specifically, we propose to obtain a multi-terab | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $500,000 | Grant | Trans-NIH Recovery Act Research Support: This is an instrumentation grant that will provide new research capabilities to a group of 20 investigators spread across the UGA campus. The instrumentation allows the collection of magnetic resonance images, as well as spectral data, on small animals ( | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $500,000 | Grant | Trans-NIH Recovery Act Research Support: A high resolution LC-MS/MS instrument will greatly expand the capabilities of the biological mass spectrometry facility to meet the increasing research needs of 31 NIH-funded investigators. Funds from NIH along with UMDNJ-Robert Wood Johnson Medical Scho | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| THE VANDERBILT UNIVERSITY | $499,995 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to acquire a highly sensitive mass spectrometer with high mass accuracy and high resolution for the proteomic analysis of complex biological samples. The instrument is needed to identify and quantify posttranslationally modifi | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $1,970,000 | Grant | Trans-NIH Recovery Act Research Support: High End Instrumentation Grant support is requested to fund the purchase of a state- of-the-art Bruker Biospec 7 Tesla, 20 cm, bore small animal MRI scanner and the associated hardware and software necessary to enhance, advance, and stimulate NIH-funded b | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC. | $2,000,000 | Grant | Trans-NIH Recovery Act Research Support: We propose to acquire a 16.4 Tesla wide-bore vertical magnetic resonance (MR) small- animal scanner equipped with multi-coil receive capability. The overall goal is to upgrade the F.M. Kirby Research Center at the Kennedy Krieger Institute (KKI) to a st | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| CORNELL UNIVERSITY, INC | $500,000 | Grant | Trans-NIH Recovery Act Research Support: This application requests support for the acquisition of a hybrid Quadrupole, Ion Mobility separation, orthogonal acceleration Time-of-Flight Tandem Mass Spectrometer (Synapt HDMS), interfaced with a fully integrated ultra-high performance liquid chromato | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| CORNELL UNIVERSITY, INC | $499,734 | Grant | Trans-NIH Recovery Act Research Support: This is a request for funds to purchase an inverted Zeiss LSM710 confocal microscope to augment a 5-year old upright Leica TCS SP2 confocal microscope that will remain in the same shared imaging facility. These instruments will be managed under MIF-Biotec | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| COLD SPRING HARBOR LABORATORY | $474,500 | Grant | Trans-NIH Recovery Act Research Support: Cancer research relies on technologies that can interrogate the entire genome, detecting deletions, copy number variants and point mutations responsible for disease. It is becoming increasingly clear that epigenetic lesions in DNA and histone modification | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| BOOZ ALLEN HAMILTON INC. | $494,000 | Contract | : Booz Allen provides comprehensive grants management support for the Eunice Kennedy Shriver National Institute of Child Health and Human Development. | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| DELOITTE CONSULTING LLP | $207,734 | Contract | : This award provides professional administrative grants and program services by providing on-site grants management expertise and coordinates on-going activities, support for program tracking databases and expertise for maintenance of program records and p | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $61,058 | Grant | Trans-NIH Recovery Act Research Support: Characterization of Small Molecule Splicing Modulators of MAPT and FGFR1. We have developed a high-throughput screening method that identifies small molecule modulators of alternative splicing events. The aims are to identify and characterize small mole | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $63,902 | Grant | Trans-NIH Recovery Act Research Support: Syntrophus Aciditrophicus (Sa) lives a syntrophic lifestyle, surviving by sharing metabolites with other species within microbial communities. Microbial communities are important to human and environmental health (e.g. infectious biofilms and bioremediati | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,724,681 | Grant | Trans-NIH Recovery Act Research Support: Data Structuring and Visualization System for Neuro-oncology. This proposal addresses the development of a system for facilitating the review of clinical patient data intended to promote an orderly process of medical problem understanding and care. The s | Health and Human Services, Department of / National Institutes of Health | 6/23/2009 |
| YALE UNIVERSITY | $781,907 | Grant | Trans-NIH Recovery Act Research Support: This proposal is based on the observation that ?-catenin protein is localized to the leading edge of migrating astrocytes. In preliminary work we have examined this increase and determined it to be dependent upon new protein synthesis. Since cadherin/cate | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| NORTHSHORE UNIVERSITY HEALTHSYSTEM RESEARCH INSTITUTE | $152,500 | Grant | Trans-NIH Recovery Act Research Support: Methicillin-resistant Staphylococcus aureus (MRSA) is the causative agent of a wide diversity of diseases ranging from benign skin infection to life-threatening diseases such as endocarditis, osteomyelitis, rhinosinusitis, sepsis, necrotizing pneumonia. R | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $5,073,075 | Grant | National Center for Research Resources, Recovery Act Construction Support: This grant application requests matching funds for the conversion of 6,660 square feet of a 37-year old existing research space in the UCLA Center for Health Sciences into a state of the art research complex 'The UCLA Yip Centnter for Oral/Head & Neck Oncol... Show more | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $49,494 | Grant | Trans-NIH Recovery Act Research Support: Title: ARE DRUG-ASSOCIATED CUES SUSCEPTIBLE TO THE BLOCKING EFFECT? The focus of this project is uncovering possible learning mechanisms by which addiction to drugs might develop. Recent hypotheses about the role of dopamine as an error detection signal | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF NEBRASKA | $97,684 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this research is to understand how bacterial autolysis contributes to biofilm formation. Bacteria are commonly found in the environment as complex biofilm communities. This has clinical significance as pathogens often form biofilms d | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $966,680 | Grant | Trans-NIH Recovery Act Research Support: INTERGRATIVE GENETIC APPROACHES TO ATHEROSCLEROSIS Common human diseases result from the interplay of many genes and the environment. During the past few years, genome-wide association studies (GWAS) have succeeded in identifying many novel loci underlyi | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| ALBERT EINSTEIN COLLEGE OF MEDICINE | $830,000 | Grant | Trans-NIH Recovery Act Research Support: Lysosomal disease represents a complex family of nearly 60 disorders linked by inherited defects in specific proteins critical for lysosomal function. While most of these proteins are hydrolytic enzymes directly responsible for degradation of complex mole | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF CHICAGO, THE | $650,000 | Contract | : The objectives of these contracts are to conduct Phase 2 and early clinical trials of NCI-sponsored agents, to evaluate biologic effects of these agents on their molecular targets, to evealuate other relevant biologic effects and to determine clinically r | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $942,533 | Contract | : The funds will be used for the following purposes in support of the Accelerating Clinical Trials of Novel Oncologic PathWays (ACTNOW) project: 1) acceleration of IRB approvals with additional regulatory personnel at each site; 2) additional patient naviga | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| LOGICAL TECHNICAL SERVICES CORP. | $499,812 | Contract | : The objective of this award is to provide comprehensive review administration support for the Natioanl Center for Research Resources (NCRR) Office of Review(OR). These services will allow the NCRR-OR to provide timely and thorough review administration o | Health and Human Services, Department of / National Institutes of Health | 7/29/2009 |
| PRICEWATERHOUSECOOPERS LLP | $1,927,502 | Contract | : The NIH Office of Management Assessment (OMA) is responsible for developing, implementing, maintaining, and sustaining the NIH Risk Management Program. Part of this effort includes working to adapt the program as the NIH risk environment changes. While t | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| CORRIGO HEALTH CARE SOLUTIONS LLC | $179,467 | Contract | : Analysis & Evaluation - Monitoring & Reporting NIH ARRA Budget Authority Usage & Distributions | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| LCG SYSTEMS LLC | $227,904 | Contract | : A) Design, development, and programming necessary for the implementation of a SharePoint based collaboration and information dissemination solution to meet the following needs: G?? Information exchange G?? Replacement of existing intranet G?? Custom repor | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| GOVERNMENT SCIENTIFIC SOURCE, INC. | $112,762 | Contract | : Item #1-CFX96 Real Time PCR System ($34,457.45)(Unit=1) Bio-Rad Part Number 1855096 Delivery to: 30/430 Product/Service Code: 6640 Product/Service Description: LABORATORY EQUIPMENT & SUPPLIES Item #2-CFX96 Real Time PCR System($34,457.45)(Unit=1) Bio-Ra | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| BECKMAN COULTER, INC. | $7,216 | Contract | : Purchase of Allegra 6 Benchtop Centrifuge, Rotor Yoke for GH-3.8 Rotor, and Microplate carriers for SX4750 Rotor, Set of 2. | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $250,000 | Contract | : The purpose of the proposed modification is to facilitate discovery and use of resources relevant to drug abuse research by accelerating and increasing enhancements to the NIF system. Specifically, the following enhancements will be delivered: A)-?-? 10 | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| AGILENT TECHNOLOGIES, INC | $185,295 | Contract | : G6410BA 6410 Triple Quadrupole LC/MS System. Includes 6410 triple quad, API-ESI sourcem MassHunter acquisition, qual,quant, and compliance software, PC and Printer, Inst. And Fam and Image recovery service. With the following configuration. Ship to countr | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| NORTHERN TAIGA VENTURES, INC. | $3,061,557 | Contract | : Building 10 Repair - Replacement of the HVAC system serving the Bldg 10 2nd floor Pathology Department. | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| ALBERT EINSTEIN COLLEGE OF MEDICINE | $71,380 | Grant | Trans-NIH Recovery Act Research Support: The supplement will employ guided discussion groups focusing on obtaining qualitative data about how various risk factors contribute to disease status as well as appropriate strategies for managing obesity and diabetes/impaired fasting glucose. The study | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| ALBERT EINSTEIN COLLEGE OF MEDICINE | $228,134 | Grant | Trans-NIH Recovery Act Research Support: The liver is the principal site for uptake and catabolism of high density lipoprotein (HDL). Scavenger Receptor B-I (SR-BI) is the primary HDL receptor mediating the hepatic uptake of extrahepatic cholesterol/cholesteryl ester carried on HDL leading to ex | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| YALE UNIVERSITY | $1,153,026 | Grant | Trans-NIH Recovery Act Research Support: The goal of this application is to provide for support for recruitment of new tenure-track in the Section of Cardiovascular Medicine and Yale Cardiovascular research Center faculty from among the graduating fellows from accredited cardiology fellowship pr | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $593,250 | Grant | Trans-NIH Recovery Act Research Support: The objective of this project is to define and implement screens leading to the discovery of inhibitors of production of the second messenger bis-(3',5')-cyclic-di-guanidine monophosphate (c-di-GMP) in Pseudomonas aeruginosa. c-di-GMP has been shown, in a | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $639,098 | Grant | Trans-NIH Recovery Act Research Support: Objectives: The objective of this study is to better understand the personal values that influence treatment choices in men with prostate cancer using a method taken from marketing research called 'Conjoint Analysis'. We will compare how accurately conjo | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $715,806 | Grant | Trans-NIH Recovery Act Research Support: This study investigates long-term outcomes of women who were pregnant or parenting at admission to women only versus mixed-gender drug treatment programs. As part of the California Treatment Outcome Project (CalTOP) conducted in multiple counties of Calif | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| YALE UNIVERSITY | $645,588 | Grant | Trans-NIH Recovery Act Research Support: Twenty millions Americans suffer from chronic kidney disease, and are at significantly greater risk for having both fatal and non-fatal cardiovascular complications. The pathogenesis of cardiac disease in this patient population is not well understood. Pa | Health and Human Services, Department of / National Institutes of Health | 8/18/2009 |
| DOHENY EYE INSTITUTE | $808,662 | Grant | Trans-NIH Recovery Act Research Support: Title: Genetic Susceptibility for Development of Proliferative Diabetic Retinopathy. Award Description: The number of individuals affected by diabetes mellitus is rising at epidemic proportions, particularly in the Latino population of th | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $955,000 | Grant | Trans-NIH Recovery Act Research Support: The goal of this grant it to maintain and extend the Fold and Function Assignment System (FFAS) server, which was started in 2000 and pioneered protein profileG??profile algorithms, applying them to protein structure and function prediction. Since then, t | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $845,000 | Grant | Trans-NIH Recovery Act Research Support: This project examines the early steps leading to an atherosclerotic lesion as a consequence of the interaction between an immune system cell, the macrophage, with lipoproteins in the wall of blood vessels. These atherosclerotic lesions can lead to heart | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $146,666 | Grant | Trans-NIH Recovery Act Research Support: A major problem with drugs of abuse is the return to drug use after a period of abstinence (relapse). A contributing factor to relapse is the withdrawal-induced anxiety and depression, which stimulates re-administration as a form of self-medication. Super | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| UNIVERSITY OF MASSACHUSETTS | $451,854 | Grant | Trans-NIH Recovery Act Research Support: Neuronal nicotinic acetylcholine receptors are ligand-gated cation channels activated by the endogenous neurotransmitter, acetylcholine (ACh), as well as the highly addictive component of tobacco, nicotine. Expression of neuronal nAChRs in the dopaminerg | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| YALE UNIVERSITY | $455,125 | Grant | Trans-NIH Recovery Act Research Support: Ixodes scapularis ticks transmit Borrelia burgdorferi, the agent of Lyme disease among other pathogens. In this proposal we will identify tick midgut proteins that interact with Borrelia during spirochete growth and migration and examine the impact of thi | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $423,500 | Grant | Trans-NIH Recovery Act Research Support: Generalized immune activation and apoptosis are key characteristics of progressive HIV-1 disease. HIV-1 Tat protein has been linked to skewing of na+?ve T-cell differentiation and apoptosis; however, the exact mechanisms are not clearly defined. The GLI | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $423,500 | Grant | Trans-NIH Recovery Act Research Support: 'Role of Sex Differences in the Expression & Function of Regulatory T Cells in SLE' Regulatory CD4+T cells and CD8+T cells have important roles in suppressing autoimmune disease in the peripheral immune system. Impaired function of regulatory/suppressor T | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $551,323 | Grant | Trans-NIH Recovery Act Research Support: The ubiquity of bacteria in nature attests to their tremendous adaptability. E. coli must routinely respond to external stress in the form of temperature change, nutrient deprivation, the presence of a drug, or a change in external solute concentration (o | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $2,220,326 | Grant | Trans-NIH Recovery Act Research Support: SUPPLEMENTAL VITAMIN D AND FUNCTIONAL OUTCOMES IN EARLY ADOLESCENCE: Vitamin D intakes in children do not meet current US Dietary Reference Intake (DRI) recommendations and emerging evidence suggest that a significant number of children, particularly thos | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| UNIVERSITY OF ROCHESTER | $999,743 | Grant | Trans-NIH Recovery Act Research Support: The proposed study will focus on an essential but neglected area of HIV prevention research: sexual behavior and determinants of HIV risk among adult minority men who have sex with women (MSW) in urban settings. Heterosexual transmission of HIV has steadi | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $1,900,741 | Grant | Trans-NIH Recovery Act Research Support: We are studying the etiology of vulvodynia, a condition characterized by chronic vulvar discomfort, most often described as burning pain, occurring in the absence of relevant visible findings or a specific, clinically identifiable, neurologic disorder. Ou | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| WAYNE STATE UNIVERSITY (INC) | $405,000 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to develop a mouse model of myopia by optimizing visual conditions for induction of experimental myopia in mice and investigating the role of the genetic background in the eye's response to visual form deprivation in mice. | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $449,458 | Grant | Trans-NIH Recovery Act Research Support: Age-related macular degeneration (AMD), the leading cause of irreversible blindness among elderly people in the developed countries, is a complex disease caused by multiple genetic and environmental factors, and currently 1.75 million people are suffering | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| UNIVERSITY OF IDAHO | $358,950 | Grant | Trans-NIH Recovery Act Research Support: An important outcome of the recent protein structure initiative is the discovery of numerous protein families that do not form compact rigid structures. These intrinsically unstructured proteins (IUPs) are common in nature and disrupting their function | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $401,955 | Grant | Trans-NIH Recovery Act Research Support: Virtually all Western marriages are preceded by a series of relationship transitions, beginning with movement into new romances (i.e., falling in love) and followed by a series of changes in the depth of association (e.g., increasing commitment versus bre | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| WOMEN & INFANTS HOSPITAL OF RHODE ISLAND | $408,100 | Grant | Trans-NIH Recovery Act Research Support: Endothelial cells which line blood vessels are a critical element in barrier function. They regulate the passage between blood and tissues of macromolecules, nutrients and waste products. During inflammation, endothelial barrier function is reduced, lead | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| NEW YORK UNIVERSITY (INC) | $464,916 | Grant | Trans-NIH Recovery Act Research Support: KATP channels are integral to the functions of many different types of cells and tissues. However, even though they were first described almost 25 years ago, the physiological and pathophysiological roles of these channels are only now emerging for most t | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $423,950 | Grant | Trans-NIH Recovery Act Research Support: Our long-range goal is to understand the cellular and molecular mechanisms of endothelial dysfunction in order to elucidate new targets for pharmacological intervention that will prevent and/or minimize vascular complications of disease. Targeting genes o | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| KENT STATE UNIVERSITY | $376,890 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this award is to identify neural substrates on which vasopressin acts via the vasopressin 1b receptor to affect social behavior in an experimental animal model. Specifically, the proposed experiments have been designed to test the central h | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF MARYLAND | $412,500 | Grant | Trans-NIH Recovery Act Research Support: The combined lifetime population incidence of mood disorders, including bipolar disorder and unipolar depression, is over 15%. Many of these individuals do not receive optimized pharmacological treatment, which is influenced by the fact that the ability t | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $381,997 | Grant | Trans-NIH Recovery Act Research Support: This is a novel and innovative program of research designed to examine the basic science and therapeutic applications of virtual reality (VR) technology in research on social skills development for children with higher functioning autism (HFA). Several st | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| TOWSON UNIVERSITY | $405,693 | Grant | Trans-NIH Recovery Act Research Support: Anorexia Nervosa (AN) has the highest mortality rate of all psychiatric illnesses. It is a debilitating condition characterized by extreme malnourishment and the potential for significant physical and psychological sequelae. AN often emerges in adolescenc | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF WASHINGTON | $985,917 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (12) Science, Technology, Engineering and Math (STEM) and specific Challenge Topic 12-OD-105: Identification of practices that overcome equity issues in STEM learning.Title: Native Youth Enrichment ProgramTh | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $645,498 | Grant | Trans-NIH Recovery Act Research Support: This ARRA grant is a mechanism of competitive supplement to the parental R01 CA125658, awarded on Septermber 29, 2009. Since we have not had time to start the project within the last two days when an account number is being setup by the PIG??s institute, | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $42,075 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement award provides funds to purchase a fluorescence microscopy imaging system that will be used to accelerate progress on electrophysiological studies of taste cell responses in gustatory neurons. The Aims of the parent grant ar | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $2,272,128 | Grant | Trans-NIH Recovery Act Research Support: We propose to conduct a validation/reproducibility study to gauge the magnitudes of both systematic errors (resulting from interview-based exposure surrogates) and random errors (resulting from within-subject variation in exposure levels) of home exposure | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $748,445 | Grant | Trans-NIH Recovery Act Research Support: Our long-term goal is an understanding of the mechanisms of eye and lens development. In this application, our more restricted goal is an understanding of how the unusual trans-membrane protein CRIM1 mediates epithelial adhesion and morphogenesis. We will | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $53,901 | Grant | Trans-NIH Recovery Act Research Support: To better understand how MEK is regulated, novel techniques will be used to perform biochemical studies in primary stem and progenitor cells. | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $83,592 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement will be to support a part-time data manager and analyst in the United States. This supplement will accelerate the pace of data analysis and publication of results for a project to determine the impact of food insecurity on H | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $92,975 | Grant | Trans-NIH Recovery Act Research Support: The ARRA supplement to 5K25CA114254 (5K25CA114254-04S1) was requested to fund activities that would accelerate the progress of the original aims of the parent grant. The focuses of the supplemental funds were identified as 1) hiring of additional staff, 2 | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $381,086 | Grant | Trans-NIH Recovery Act Research Support: Lichen Planus (LP) is a chronic, inflammatory--and, so far, incurable--disease of unknown etiology, affecting skin and mucosa of approximately 2% of the population. Because several clinical studies have indicated that LP patients have an increased risk fo | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| UNIVERSITY OF MIAMI | $72,901 | Grant | Trans-NIH Recovery Act Research Support: Autism spectrum disorders (ASD) affect approximately 1 out of 150 children and adolescents in the United States, making them one of the most common neurobiological conditions. Comorbid anxiety disorders affect as many as 80% of youth with ASD, causing sub | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| PROTHELIA | $251,936 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Our objective is to develop an intravenously delivered protein therapy for treatment of Duchenne muscular dystrophy (DMD), a disease that occurs in 1 of every 3500 male births. DMD is caused by a deficiency of dystroph | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| CONNECTIVE ORTHOPAEDICS | $157,848 | Grant | Trans-NIH Recovery Act Research Support: This study will establish proof of principle for an innovative technique of ACL repair with a device made of collagen and autologous platelets which stimulates healing of the transacted ACL. The advantages over the current gold standard of treatment of A | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| PLASMA CONTROLS, LLC | $99,996 | Grant | Trans-NIH Recovery Act Research Support: Plasma Controls is investigating plasma-based ion implantation & deposition (PBII&D) as a method to deposit biomedical coatings on titanium-based materials commonly used in dental implant devices. The goal of the project is to deposit a high quality coati | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| TISSUE REGENERATION SYSTEMS, INC. | $121,338 | Grant | Trans-NIH Recovery Act Research Support: SBIR Grant-Designed Scaffolds for Mandibular Reconstruction | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF IOWA, THE | $403,341 | Grant | Trans-NIH Recovery Act Research Support: The Severe Acute Respiratory Syndrome, caused by a novel coronavirus (SARS-CoV), resulted in substantial morbidity and mortality in 2002-2003. With the lack of recurrence of SARS, research efforts to develop an effective vaccine have largely halted. Howev | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| NORTHWESTERN UNIVERSITY | $65,594 | Grant | Trans-NIH Recovery Act Research Support: The neuroinvasive herpesviruses are a highly-prevalent group of the alpha-herpesvirus subfamily that includes the human pathogens: herpes simplex virus types 1 and 2 (HSV-1, HSV-2), and varicella zoster virus (VZV). An additional member of this group is a | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF CINCINNATI | $293,500 | Grant | Trans-NIH Recovery Act Research Support: The dimorphic fungus, Histoplasma capsulatum (Hc) is endemic to the Midwestern and southeastern United States. Most infections are mild or asymptomatic. The organism establishes a latent state and can cause a life-threatening infection in immunocompetent | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $385,380 | Grant | Trans-NIH Recovery Act Research Support: Rheumatoid arthritis (RA) is a chronic, disabling disease that can compromise daily functioning, and health related quality of life (HRQOL), especially in young persons for whom long-term medication use can lead to adverse side effects. There is an urgent | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $423,500 | Grant | Trans-NIH Recovery Act Research Support: Cell Phone Use and the Health of Children in the Danish National Birth Cohort With the rapid advances in communication technologies, children are increasingly exposed to the radiofrequency (RF) fields starting from a very early age. This will be the firs | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF NEBRASKA | $384,756 | Grant | Trans-NIH Recovery Act Research Support: The work proposed could advance our fundamental understanding of the key factors that control the synthesis of mucin carbohydrates, the main determinants of mucin functions. The knowledge gained could help design strategy to develop therapeutic agents to | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| YALE UNIVERSITY | $454,081 | Grant | Trans-NIH Recovery Act Research Support: Heart Failure affects over 5 million Americans and is associated with poor functioning, negative symptoms, and poor quality of life. Insomnia, a disorder of initiating and maintaining sleep, is common in these patients and contributes to daytime symptoms | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $983,175 | Grant | Trans-NIH Recovery Act Research Support: Chronic Stress Mediates Fat-Related Changes in Insulin Signaling and Gut Motility Visceral adipose tissue, a key endocrine organ involved in the regulation of insulin action and dysregulation of insulin signaling in adipocytes, is an important component | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $393,428 | Grant | Trans-NIH Recovery Act Research Support: Reducing Barriers to Gender Equity in STEM Fields by Reducing Stereotype Threats. Although there has been progress over the past 30 years, women are still under-represented in Science, Technology, Engineering, and Math (STEM) fields. In contrast to many e | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MAYO CLINIC | $1,160,811 | Grant | Trans-NIH Recovery Act Research Support: Type 2 diabetes mellitus (DM2), is causally associated with coronary artery disease (CAD), and is a major health and economic burden. Despite multiple preventive and therapeutic measures implemented in the last few decades to decrease the occurrence and p | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $898,688 | Grant | Trans-NIH Recovery Act Research Support: Asthma is a disease of rapidly increasing incidence that affects more than 17 million people in the United States alone. It is of major importance to understand the causes of heterogeneous ventilation and airway obstruction, cardinal features responsible | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $713,542 | Grant | Trans-NIH Recovery Act Research Support: Myocardial tissue can remain viable, despite a prolonged period of reduced blood flow. Referred to as 'hibernation', the entity is observed experimentally and has important clinical implications for patients with advanced coronary artery disease and ische | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF UTAH, THE | $728,892 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Experimental and clinical approaches for treating heart failure (HF) have traditionally focused on interrupting processes involved with its development, and in particular, understanding and preventing the transition fr | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $866,898 | Grant | Trans-NIH Recovery Act Research Support: Angiography is the standard method for determination of coronary anatomy and assessment of atherosclerosis. However, there are definite limitations to the use of visual estimation to assess the severity of coronary artery disease and luminal stenosis. The | Health and Human Services, Department of / National Institutes of Health | 7/03/2009 |
| BOSTON BIOMEDICAL RESEARCH INSTITUTE, INC. | $1,153,892 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of this award is to determine the role of Mdm2 and its homolog Mdm4 in maladaptive cardiac hypertrophy and the associated apoptosis. Mdm2 is an E3 ubiquitin ligase, which promotes the proteasome-mediated degradation of the tumor suppr | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $997,175 | Grant | Trans-NIH Recovery Act Research Support: The major coronary arteries form in stereotyped locations. Abnormalities in location such as in Anomalous Left Coronary Artery from the Pulmonary Artery (ALCAPA) have serious clinical consequences including sudden death. The overall aim of this study is t | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| TUFTS MEDICAL CENTER PARENT, INC. | $437,250 | Grant | Trans-NIH Recovery Act Research Support: Diabetic Autonomic Neuropathy (DAN) is characterized by impairment of autonomic responsiveness of the heart. DAN has been associated with an increased incidence of arrhythmia and sudden death in diabetics. Although the overall incidence of sudden death is | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $484,000 | Grant | Trans-NIH Recovery Act Research Support: Physical activity reduces morbidity and mortality from many chronic conditions including coronary heart disease, hypertension, and diabetes. Increasing physical activity in the United States is a specific goal of Healthy People 2010. The Surgeon General?s | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| SEATTLE BIOMEDICAL RESEARCH INSTITUTE | $505,715 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis (TB) retains its place as a global scourge, killing an estimated 2 million people per year despite the availability of chemotherapy. The huge majority of cases are clinically latent and remain difficult to diagnose. Control of the global epid | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| PLANCHE CONSULTING, INC. | $528,825 | Grant | Trans-NIH Recovery Act Research Support: Obstructive Sleep Apnea (OSA) affects about 4% of men and 2% of women of adult population. It is caused by partial or complete airway obstruction in individuals with anatomically compromised airways due to a decrease in upper airway muscle (including geni | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $412,556 | Grant | Trans-NIH Recovery Act Research Support: Functional changes in the 2-adrenergic system play an important role in the pathophysiology of heart failure (HF) in adults. Experimental data has extensively defined many of the components involved in the 2-adrenergic receptor (2-AR) response in HF resul | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF WASHINGTON | $393,640 | Grant | Trans-NIH Recovery Act Research Support: This project focuses on the role that cytoskeletal forces play in platelet adhesions to mediate the formation and stability of clots. Platelet adhesion significantly influences thrombosis since platelets need to aggregate together to stop blood loss, but | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $1,057,419 | Grant | Trans-NIH Recovery Act Research Support: The simultaneous identification of multiple novel disease loci in genome wide association studies (GWAS) has highlighted a need for efficient model systems both to define the causal gene(s) at each locus, and to explore disease mechanisms 2, 3. Many GWAS | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| PACIFIC INSTITUTE FOR RESEARCH AND EVALUATION | $427,262 | Grant | Trans-NIH Recovery Act Research Support: Several decades of research have enabled the identification of curricula that prevent, or at least delay, substance use initiation. Research clearly shows that these curricula are most effective when they are implemented with fidelity; however, research a | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| NATIONAL DEVELOPMENT AND RESEARCH INSTITUTES, INC. | $345,400 | Grant | Trans-NIH Recovery Act Research Support: This project proposes to evaluate the feasibility of an online parenting training approach for influencing mother-adolescent communication about drugs. Parent-adolescent communication has consistently emerged as an important deterrent to initiation and p | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $435,042 | Grant | Trans-NIH Recovery Act Research Support: In spite of 20 years of investigations of the effects of prenatal cocaine exposure in rodents, no one has modeled the binge pattern associated with smoking crack/cocaine in a pregnant rat. Cocaine use has gone down nationwide, but there remains a substant | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| CATHOLIC HEALTHCARE WEST | $407,127 | Grant | Trans-NIH Recovery Act Research Support: Nicotinic acetylcholine receptors (nAChRs) play critical physiological roles throughout the brain and body by mediating cholinergic excitatory neurotransmission, modulating the release of neurotransmitters, and having longer-term effects on, for example, | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| RFCUNY - HUNTER COLLEGE | $417,645 | Grant | Trans-NIH Recovery Act Research Support: This project investigates the synergistic relationship among neurocognitive, dispositional, and contextual factors in HIV risk behavior among men who have sex with men (MSM). In neuropsychological research, a link has been made between substance dependen | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $411,004 | Grant | Trans-NIH Recovery Act Research Support: The increasing trend in the addiction to opioids is a problem of critical importance during pregnancy. New options for substitution therapies in pregnant opioid addicts include buprenorphine, a mu-opioid receptor partial agonist and kappaopioid receptor a | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF FLORIDA | $366,250 | Grant | Trans-NIH Recovery Act Research Support: The majority of microorganisms in natural and biological ecosystems exist as biofilms, allowing them to better tolerate stresses and fluctuating environmental conditions. Dental plaque is a complex biofilm on the tooth surface that is subject to fluctuati | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $421,375 | Grant | Trans-NIH Recovery Act Research Support: Porphyromonas gingivalis, a gram-negative anaerobic bacterium, is a recognized periodontopathogen. Although this pathogen mainly inhabits periodontal pockets it also is present in other niches of the oral cavity enroute to the periodontal pockets such as | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $424,875 | Grant | Trans-NIH Recovery Act Research Support: Regulation of gene transcription in the gonadotrope is a key regulatory step that determines the levels of gonadotropin hormones and therefore, regulates gonadal function. Gametogenesis and steroidogenesis in both sexes are controlled by these two hormone | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF NEBRASKA | $400,715 | Grant | Trans-NIH Recovery Act Research Support: This R21 application seeks two years of funding to support measurement and design preparation for a multi-site, longitudinal R01 to investigate health disparities among homeless women. The first specific aim of this application is to work with national ex | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $397,705 | Grant | Trans-NIH Recovery Act Research Support: Down Syndrome (DS), or trisomy 21, is the most common genetic developmental disorder that leads to mental retardation. Mouse models have implicated reduced neurogenesis and faulty synaptic development as important contributors to the mental impairment ch | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $570,222 | Grant | Trans-NIH Recovery Act Research Support: The clinical manifestation of autism spectrum disorder (ASD) is highly complex and heterogeneous, with medical and mental health disruptions beyond the three core behavioral criteria used for diagnosis (social behavior, communication, restricted interests | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| RUSH UNIVERSITY MEDICAL CENTER | $400,250 | Grant | Trans-NIH Recovery Act Research Support: This study compares an asthma self-management intervention, delivered to the family and tailored to their needs and cultural beliefs, to standard asthma education on these two risk factors for asthma exacerbations in high-risk Puerto Rican children in ele | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $485,419 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this research project is to develop a noninvasive Magnetic Resonance/Optical Imaging test to assess and predict ischemic brain damage and recovery after acute hemorrhage using a rat model. Patients who suffer acute blood loss (e.g. fro | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $395,443 | Grant | Trans-NIH Recovery Act Research Support: Mechanical Forces play important roles in the normal development and maintenance of blood vessel structure. Perturbations in the normal mechanical environment contribute to the pathological remodeling associated with diseases such as atherosclerosis, hype | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $492,990 | Grant | Trans-NIH Recovery Act Research Support: This project will help improve a method to genetically alter human embryonic stem cells in order to faithfully and easily measure the activity of several heart specific genes. This method, called gene targeting, will greatly facilitate development of pr | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $5,996,302 | Grant | Trans-NIH Recovery Act Research Support: Most human tumors, particularly those derived from epithelial cancers, exhibit global genomic alterations that make it difficult to identify mutations critical for cell transformation and to define the consequences of specific cancer-associated mutations. | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $4,800,000 | Grant | Trans-NIH Recovery Act Research Support: The lack of sensitive, specific, multiplex-able assays for most human proteins is a major technical barrier that impedes progress in the biomedical sciences by prohibiting hypothesis testing in quantitative proteomics, where relationships between protein | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| OHIO STATE UNIVERSITY, THE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Patients infected with HIV are at increased risk of developing malignant B cell lymphoproliferative diseases (LPD). The majority of these LPDs are positive for the Epstein-Barr virus (EBV), run an aggressive clinical course and are associated with a poor | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $999,578 | Grant | Trans-NIH Recovery Act Research Support: Development of low cost and broadly protective human papillomavirus vaccines. HIV+ patients exhibit more severe and progressive human papillomavirus (HPV) infections than HIV- individuals, and consequently cervical cancer has been designated an HIV-associ | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE | $2,535,000 | Grant | Trans-NIH Recovery Act Research Support: The vast majority of cancer deaths result from the metastatic spread of cancer cells to distal organs. Systemic chemotherapy can prevent metastasis in some patients by killing microscopic tumor cells throughout the body. Chemotherapy can also dramatically | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CONNECTICUT | $36,569 | Grant | Trans-NIH Recovery Act Research Support: Osteoporosis is a disease that is characterized by low bone mass and increased risk of fracture. The only available therapy to increase bone mass is daily injection with parathyroid hormone, while other therapies inhibit bone loss. Our goal is to study t | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| SRI INTERNATIONAL | $500,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): SRI International is an independent, nonprofit research institute chartered by the State of California to conduct scientific research for the public benefit. Research is conducted under contracts and grants from govern | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $492,780 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The University of Michigan has an extensive program for care and use of laboratory animals campus-wide. This program includes animal housing facilities in 27 buildings on the Ann Arbor campus, two farm-based settings, | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| NATIONAL ASSOCIATES, INC. | $71,386 | Contract | : Administrative Assistant support to the contract data management program. | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $63,396 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the proposed study is to identify novel mechanisms regulating the transcriptional activity of Estrogen Related Receptor beta (ERRb). Using a variety of approaches, we expect to identify protein regulators of ERRb and elucidate the specific | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $92,556 | Grant | Trans-NIH Recovery Act Research Support: Mitochondria have emerged as central regulators of lifespan, through their functions in aerobic energy mobilization, cellular metabolic control, and reactive oxygen species (ROS) production. Moreover, there are numerous descriptions of age-associated dege | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| MEHARRY MEDICAL COLLEGE | $74,350 | Grant | Trans-NIH Recovery Act Research Support: The Human Immunodeficency Virus has caused a worldwide pandemic. Supporting strategies through basic science research that treat and prevent infectious disease like HIV is part of NIAID's mission. The purpose of this work is to elucidate the virus-host ce | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| RFCUNY - THE GRADUATE CENTER | $52,260 | Grant | Trans-NIH Recovery Act Research Support: The management of HIV infection and the control of further transmission require HIV+ individuals to exhibit behavioral control in several domains, including the maintenance of near perfect adherence. Methamphetamine is a known barrier to treatment adheren | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF MARYLAND | $51,132 | Grant | Trans-NIH Recovery Act Research Support: To date, methadone-drug interactions is a field of research that is characterized asymmetrically among published scientific literature. The majority of reports focus intensively on characterization of how other drugs affect the metabolic & pharmacokinetic | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $102,208 | Grant | Trans-NIH Recovery Act Research Support: The emergence and reemergence of epidemic arthropod borne diseases has led to significant world wide morbidity and mortality. These vector borne viruses have not only developed highly effective strategies to hijack cellular machinery and to subvert host i | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $43,020 | Grant | Trans-NIH Recovery Act Research Support: Enterococcus faecalis is a Gram-positive constituent of the gastrointestinal microflora and a significant cause of nosocomial infections. E. faecalis and other enterococci are recalcitrant to many antimicrobial therapies due to innate and acquired resista | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $50,054 | Grant | Trans-NIH Recovery Act Research Support: Type 3 secretion is a common virulence mechanism utilized by many Gram-negative bacteria. These pathogens require these specialized secretion systems for survival in the host organism, therefore type 3 secretion systems are a good target for antimicrobial | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $97,684 | Grant | Trans-NIH Recovery Act Research Support: How do all the complex reactions composing a living cell work together to allow growth and accurate cell division? My work focuses on unraveling these mysteries in a simple bacterial cell. Key players in regulating bacterial cell growth are the histidine | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| CORNELL UNIVERSITY, INC | $50,054 | Grant | Trans-NIH Recovery Act Research Support: All viruses infecting vertebrates interact with receptors during the process of cell infection, and also are challenged by antibodies that are either pre-existing in the host or generated shortly after infection. Both these interactions are critical to th | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $102,208 | Grant | Trans-NIH Recovery Act Research Support: The outer membrane (OM) of a Gram negative bacterium is its interface with the outside world. The OM acts as a selective barrier to block harmful substances (such as drugs or viruses) and pass critical nutrients. OM composition is traditionally studied in | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF MONTANA SYSTEM | $496,613 | Grant | Trans-NIH Recovery Act Research Support: The long-term goals of The University of Montana-Missoula (UM) are to develop and maintain the institutional infrastructure and programs necessary for a stat-of-the-art animal resource program and continued accreditation by the Association for the Assessm | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SCHEPENS EYE RESEARCH INSTITUTE, INC., THE | $499,207 | Grant | Trans-NIH Recovery Act Research Support: Supports renovations to the Animal Facility that will renovate 5 rooms to provide dedicated BL2 rooms for mice and rabbits that include ante room, gowning room, rabbit holding room, rabbit procedure room, mouse holding room and mouse procedure room. Reno | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| DUKE UNIVERSITY | $500,000 | Grant | Trans-NIH Recovery Act Research Support: The objectives of this animal facilities improvement grant application are to upfit the Bryan animal facility as follows: 1) Replace the antiquated cage washer and add an autoclave to support a wider variety of rodent housing; 2) add a biological safety c | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $77,869 | Grant | Trans-NIH Recovery Act Research Support: Use of hair dyes and other personal-appearance products has a major public health impact worldwide, particulary among woment. In most countries, the hairdressing profession, including exposures, process, and protectuion, is unregulated and employment dat | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| THOMAS JEFFERSON UNIVERSITY | $2,676,279 | Grant | Trans-NIH Recovery Act Research Support: The experiments in this project are designed to generate improved vaccines against HIV-1 based on recombinant vesicular stomatitis viruses. The vaccine vectors developed in this project will be compared with recombinant RV and NDV vectors generated in pro | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE | $4,392,897 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION 3 OVERALL PROGRAM CRITIQUE 3 PROGRAM LEADERSHIP 5 PROGRAM AS AN INTEGRATED EFFORT 5 PROJECT AND CORE SUMMARIES OF DISCUSSION 6 HUMAN SUBJECTS (Resume) 8 BUDGETARY OVERLAP 9 COLLABORATING INSTITUTIONS 9 INDIVIDUAL PROJECTS AND CORES 10 PROJECT | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | $983,591 | Grant | Trans-NIH Recovery Act Research Support: The Developmental Center for Neuroregulation in Alcohol Dependence (CeNiAD) grew from the clinical observation that the CNS active generic CM adrenoreceptor (AR) antagonist prazosin reduced or eliminated alcohol drinking in veterans with posttraumatic str | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NEW MEXICO | $1,177,192 | Grant | Trans-NIH Recovery Act Research Support: Brief Description of the Proposed Exploratory NCMHD Center of Excellence: The RWJF Center for Health Policy is an integral part of the University of New Mexico and serves as a university-wide, organized research center serving all the faculties of the Uni | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $890,480 | Grant | Trans-NIH Recovery Act Research Support: Alcohol abuse dependence constitute a major public cealth problem in the US and other Western Countries. Genetic risk factors have been consistently shown to contribute strongly to the risk for alcoholism. Technological and experimental innovations are sw | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| RUSH UNIVERSITY MEDICAL CENTER | $774,737 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to continue the development of a Core Center in Bone and Cancer at Rush University Medical Center by facilitating the recruitment of a new early stage investigator to a tenure-track faculty position. The Medical Center has a l | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $1,602,390 | Grant | Trans-NIH Recovery Act Research Support: The Stanford Cancer Center has a major interest in developing new treatments for cancer that are based on the best science. Recent data indicate that many solid tumors contain a subset of cells that are capable of propagating that tumor in immunodeficient | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $1,530,000 | Grant | Trans-NIH Recovery Act Research Support: Addiction is a chronic, relapsing brain disorder. While treatment can work to decrease morbidity and mortality associated with this disorder, a larger armamentarium of effective and accessible treatments for addiction is needed to significantly reduce the | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| FORSYTH DENTAL INFIRMARY FOR CHILDREN | $1,840,766 | Grant | Trans-NIH Recovery Act Research Support: The Forsyth Institute's second century will see exciting new changes in location, research opportunities and resource availability. In 2010, Forsyth, the world leader in oral and craniofacial research will relocate to Cambridge, MA. The uncommitted growth | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $762,302 | Grant | Trans-NIH Recovery Act Research Support: The Department of Biomedical Engineering (BME) at Case Western Reserve University (CWRU) views translational research, nanotechnology, and development of biomedical and radiologic imaging as part of its vision and mission. Via the recruitment of a tenure- | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $684,300 | Grant | Trans-NIH Recovery Act Research Support: Award Description Metal centers are essential and abundant cofactors in fundamental life processes such as respiration, photosynthesis, and carbon, hydrogen, nitrogen and sulfur metabolism and the number and diversity of metalloproteins and the biological | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| EMORY UNIVERSITY | $718,328 | Grant | Trans-NIH Recovery Act Research Support: One of the long-term goals of researchers at Emory University, specifically within the FAME center, is to elaborate and reconcile the potentially conflicting but ultimately complementary paradigms of synthetic chemistry and evolutionary biology. This desi | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF ROCHESTER | $767,221 | Grant | Trans-NIH Recovery Act Research Support: This proposal presents the rationale for a request for initial funds to hire a new tenure-track faculty member in the RNA Center for Biology at the University of Rochester Medical Center. The faculty member will join a highly integrated and interactive gr | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $1,381,681 | Grant | Trans-NIH Recovery Act Research Support: The objective of this proposal is to recruit a newly independent investigator (NIl) to a tenure track position in the Division of Pulmonary Critical Care Medicine (DPCCM). The NIl will be incorporated into the collaborative environment of the USC Center f | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $1,192,033 | Grant | Trans-NIH Recovery Act Research Support: Columbia University Medical Center (CUMC) contains several large research programs in basic cardiovascular research and clinical heart failure. In response to this P30 program, the Department of Medicine and the Cardiovascular Research Initiative (CVRI) h | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $1,393,524 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Since the completion of the Human Genome Project, there has been a rapid expansion in genetic technologies aimed at understanding complex human diseases, including high-density SNP genotyping for case-control and popul | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CHICAGO, THE | $1,082,182 | Grant | Trans-NIH Recovery Act Research Support: The present application is to enhance research efforts at the University of Chicago that aim to advance the understanding and treatment of sleep disorders by obtaining support for the hiring of a new tenure-track faculty at the Assistant Professor level. | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $1,436,500 | Grant | Trans-NIH Recovery Act Research Support: This project is submitted by the Mood Disorders Translational Core Center (MD-TCC), within the Center for Biomedical Neuroscience at the University of Texas Health Science Center at San Antonio. The MD-TCC is comprised of a core group of preclinical and c | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF WASHINGTON | $1,379,905 | Grant | Trans-NIH Recovery Act Research Support: The molecular basis of emotional learning is a rapidly evolving research topic that has crucial implications for the treatment of a variety of mental conditions, including posttraumatic stress disorder, depression, and anxiety disorders. While there is a | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| EMORY UNIVERSITY | $1,192,500 | Grant | Trans-NIH Recovery Act Research Support: Systems and Computational Neuroscience at Emory University We seek to foster and enhance Systems and Computational Neuroscience at Emory University by hiring a new assistant professor with primary appointment in the Department of Biology and adjunct appoi | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,383,412 | Grant | Trans-NIH Recovery Act Research Support: The project titled ?Alcohol sensitivity and PET derived measures of opioid activity? investigates whether differences in opioid activity may contribute to individual differences in alcohol sensitivity and ultimately to development of alcohol use disorders | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $782,500 | Grant | Trans-NIH Recovery Act Research Support: Statistics on the health-related and economic costs of alcohol abuse were summarized in the application. We consider that the consequences of acute intoxication and of alcohol consumption by individuals with reduced acetaldehyde dehydrogenase 2 activity c | Health and Human Services, Department of / National Institutes of Health | 6/09/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,817,459 | Grant | Trans-NIH Recovery Act Research Support: Older adults exhibit considerable heterogeneity of immune and health phenotypes. Many of them are surviving well beyond the median lifespan of many populations and have exceptional health and performance. Healthy aging is likely to be dependent on unique | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $1,297,195 | Grant | Trans-NIH Recovery Act Research Support: We recently completed a clinical trial testing the effectiveness of a care management program within primary care for older adults with Alzheimer's disease. Based on the clinical trial, which demonstrated the effectiveness of collaborative care, we identi | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| WAKE FOREST UNIVERSITY | $854,707 | Grant | Trans-NIH Recovery Act Research Support: This project aims to develop methods for analyzing complex interactions in longitudinal data collected from biomedical studies that contain a strong social and behavioral component. Of special interest are data collected on elderly populations, within whi | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| NORTHWESTERN UNIVERSITY | $752,688 | Grant | Trans-NIH Recovery Act Research Support: Abstract: DESCRIPTION (provided by applicant): Tau proteins normally stabilize microtubules in neuronal processes in the brain. During the course of Alzheimer's disease and certain other neurodegenerative diseases, these proteins dissociate from the micro | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $1,078,635 | Grant | Trans-NIH Recovery Act Research Support: Oligomers formed by the amyloid beta peptide, A-beta, have been shown to be neurotoxic, can permeabilize biological membranes and are believed to be critical players in Alzheimer's disease (AD). Applying traditional approaches to study these oligomers and | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF FLORIDA | $1,573,741 | Grant | Trans-NIH Recovery Act Research Support: Accidental falls are among the most common reported adverse events which occur during hospitallization. Beginning Oct.1, 2008 the CMS no longer reimburses hospitals for the treatment of injuries resulting from falls which occur during hospitalization. The | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $996,327 | Grant | Trans-NIH Recovery Act Research Support: One of the major obstacles in our understanding of memory ageing is lack of an effective tool to address the fundamental questions such as: what are memory traces? What are the major alterations in the network-level dynamics and memory-encoding patterns d | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $164,000 | Grant | Trans-NIH Recovery Act Research Support: Project title: CMV-encoded TNF receptor and virus dissemination The aims of the project are: to characterize NF-kB activiation with UL144 subtypes, to understand which region of UL144 is responsible to NF-kB activation, and to determine the effects of UL1 | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $170,250 | Grant | Trans-NIH Recovery Act Research Support: In India, cervical cancer is one of the leading causes of cancer in women, with age-standardized rates (ASR) that vary from 18 to 30 per 100,000. This is in contrast to the United States, where the ASR is as low as 3 per 100,000. The difference is primari | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA BARBARA | $844,296 | Grant | Trans-NIH Recovery Act Research Support: The original application proposed a comprehensive characterization of morphogenesis in both wild type and experimentally manipulated embryos. Emphasis was to be placed on characterizing morphogenesis in both the notochord and the central nervous system. W | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| TEACHERS COLLEGE, COLUMBIA UNIVERSITY | $639,423 | Grant | Trans-NIH Recovery Act Research Support: This project examines adolescent health risk behaviors and their familial antecedents in the context of neighborhoods. Using data from the Project on Human Development in Chicago Neighborhoods (PHDCN), we will address the following research questions usin | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $157,000 | Grant | Trans-NIH Recovery Act Research Support: This application is to find out why kallikreins are regulated and how they exert protective effect against immune nephritis. Finally we will develop a mouse model in which we can control the kallikreins expression specifically in kidney during specific di | Health and Human Services, Department of / National Institutes of Health | 6/10/2009 |
| UNIVERSITY OF MASSACHUSETTS | $536,260 | Grant | Trans-NIH Recovery Act Research Support: Assembly and disassembly of proteins, natures macromolecules, in response to a specific stimulus is ubiquitous in biology. Mimicking these processes, where proteins are used as the stimulus to disassemble artificial macromolecular assemblies are interesti | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $834,130 | Grant | Trans-NIH Recovery Act Research Support: During development of the immune system, antigen receptor genes in B and T cells are assembled from germline coding gene segments by a site-specific somatic recombination process termed V(D)J recombination. Defects in this pathway result in a number of pr | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| CHILDREN'S HOSPITAL | $752,875 | Grant | Trans-NIH Recovery Act Research Support: Atypical G Protein signaling in Cryptococcus neoformans The heterotrimeric G protein plays an important regulatory role in the human pathogenic fungus Cryptococcus neoformans. The G1 subunit Gpa1 governs a conserved cAMP-dependent signaling pathway that | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF WASHINGTON | $774,000 | Grant | Trans-NIH Recovery Act Research Support: West Nile virus (WNV) is an NIAID Category B infectious agent that can cause severe encephalitis, encephalopathym and paralysis in humans and other animals. Pathogenic WNV has emerged into the Western hemisphere and presents a serious public health threa | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| DREXEL UNIVERSITY | $536,958 | Grant | Trans-NIH Recovery Act Research Support: The echinocandins (ECs) are a new antifungal group that includes caspofungin, micafungin, and anidulafungin. ECs represent a profoundly important development in antifungal chemotherapy because they are generally fungicidal, non-toxic, and remain active v | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| WASHINGTON UNIVERSITY, THE | $691,082 | Grant | Trans-NIH Recovery Act Research Support: Project is on No Cost Extension through 5/31/12. This is a modified abstract. The first paragraph is the original project description; this is followed by a short description of a recent modification to this project. We cloned the novel inhibitory recep | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF PITTSBURGH THE | $748,546 | Grant | Trans-NIH Recovery Act Research Support: The award concerns the discovery and development of novel therapeutic agents that target HIV-1 ribonucleaseH (RNH) and bifunctional agents that target both HIV-1 reverse transcriptase DNA polymerase activity and RT-associated RNH activity. The overall hyp | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF MARYLAND | $750,000 | Grant | Trans-NIH Recovery Act Research Support: Type 1 interferons (IFNs) were discovered as mediators of host antiviral functions, and were recently shown to play essential roles in the innate immune response to nonviral pathogens. Established effectors of IFN antiviral action may thus serve previousl | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $1,006,600 | Grant | Trans-NIH Recovery Act Research Support: This project concerns a never-investigated dimension of the world's most important insect. Until now, virtually nothing was known about the existence or significance of a plant-vector relationship in African malaria. It was assumed that plants play no sig | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF CHICAGO, THE | $760,712 | Grant | Trans-NIH Recovery Act Research Support: An outstanding question in lymphocyte developmental biology is how a cell with multiple differentiation options becomes restricted to a single developmental fate. Understanding how B- and T-lymphocyte lineage restriction occurs is also clinically relevant | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF HOUSTON SYSTEM | $1,036,014 | Grant | Trans-NIH Recovery Act Research Support: Asthma is characterized by airway obstruction, airway hyperresponsiveness (AHR) and airway inflammation. The medications used for control and acute relief of asthma may vary in effectiveness and produce serious side effects. Also, ~30% of asthma patient | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| THE INSTITUTE FOR CANCER RESEARCH | $866,336 | Grant | Trans-NIH Recovery Act Research Support: Abstract: Differentiation of thymocytes into alternate T killer and helper lineages is of great interest, due to its importance in shaping the T cell compartment and as a paradigm of binary lineage decisions. Recently, the transcription factor Zbtb7b has | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $364,000 | Grant | Trans-NIH Recovery Act Research Support: The survival of every species depends on the faithful inheritance of genetic information. Essential to this process are the accurate movement and positioning of chromosomes and plasmids to daughter cells at cell division. The ultimate goal of this proposa | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $818,568 | Grant | Trans-NIH Recovery Act Research Support: Inflammation is an essential host response to tissue damage and/or infection. While it is largely in the confines of an innate response during its initial stages, in vertebrates, it has evolved to require a T cell cytokine, IL-17, to promote the expansion | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $785,000 | Grant | Trans-NIH Recovery Act Research Support: Autoimmune diseases (for example, rheumatoid arthritis) affect millions of individuals worldwide and thus represent a significant health challenge. Both the damage and control processes in autoimmune disease involve special white blood cells (T cells) abl | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| FORSYTH DENTAL INFIRMARY FOR CHILDREN | $1,101,539 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this study is to understand the mechanism underlying transcription factors specifying osteoclast lineage commitment and differentiation. This proposal is highly significant since elucidating osteoclast lineage commitment and differenti | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $745,250 | Grant | Trans-NIH Recovery Act Research Support: Hox genes encode homeodomain-containing transcription factors that are expressed and function along the body axis in an AP-restricted manner corresponding to their position within the cluster. This pattern of global Hox expression is termed colinearity an | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $318,686 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this proposal is to reconstitute the signaling process in space and time in cancer cells and to integrate the new experimental data into a computational model of the dynamics of the EGFR-MAPK pathway. Firstly, the components of the MAP | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $613,027 | Grant | Trans-NIH Recovery Act Research Support: Ack1: Activation and Consequences in Prostate Cancer Prostate cancer, the most common male malignancy, takes the lives of 30,000 men annually, as it progresses to a hormone-refractory cancer that invades surrounding tissue and bone. Our investigation int | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| NORTHWESTERN UNIVERSITY | $550,807 | Grant | Trans-NIH Recovery Act Research Support: Investigating the chemical reactivity and biological activity of anti-tumor natural products is vital to understanding their mechanism of action and developing new therapeutics for the treatment and/or prevention of cancer. This research program aims to d | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $788,086 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this grant is to investigate the mechanism of oncogene-induced senescence, an important tumor suppressive cellular response that is disrupted during human cancer development. Our study will focus on a potential tumor suppressor protein | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $291,017 | Grant | Trans-NIH Recovery Act Research Support: Current technology advances have brought us massive biomedical data for statistical analysis, for example, the cancer microarray data. Typical of these data is the common feature that the number of observed samples is much smaller than the number of varia | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| DUKE UNIVERSITY | $647,400 | Grant | Trans-NIH Recovery Act Research Support: Lung cancer is the leading cause of cancer related death in the United States. Gene expression profiles in non- small cell lung cancer (NSCLC) reflect unique aspects of individual tumors and provide precise prognostic information. In previously published | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF OKLAHOMA | $824,927 | Grant | Trans-NIH Recovery Act Research Support: Fluorescent in situ hybridization (FISH) imaging has been proven as a powerful molecular imaging tool to detect cancers, predict cancer prognosis, and monitor therapy efficacy. However, manual FISH analytic method is a tedious procedure, and introducing i | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $738,188 | Grant | Trans-NIH Recovery Act Research Support: The development of an effective HIV vaccine is one of the greatest global health challenges. However despite decades of research, no vaccine has yet been able to elicit protective immunity to HIV. Recently, efforts to develop vaccines against HIV have foc | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $0 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this proposal is to elucidate the mechanisms by which lung tumor exosomes promote an inflammatory response, namely the activation of macrophages, and promote the progression and growth of lung tumors. Our preliminary data iandicate th | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $634,950 | Grant | Trans-NIH Recovery Act Research Support: Our long-term goal is to understand the tissue-specific function of BRCA1 and how its impairment leads to breast tumorigenesis. In the past decades, others and we have focused on elucidating roles of BRCA1 in DNA damage response and cell cycle checkpoint | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $692,101 | Grant | Trans-NIH Recovery Act Research Support: Non-small cell lung carcinoma (NSCLC) is highly correlated with smoking and smokers constitute about 75% of NSCLC patients. Many tobacco-specific carcinogens present in cigarette smoke cause DNA damage, leading to the mutation of vital genes like Ras, p53 | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $913,763 | Grant | Trans-NIH Recovery Act Research Support: Although there has been substantial progress in the understanding of the molecular biology and genetics of non-small cell lung cancer (NSCLC) over the last several years, metastatic NSCLC remains incurable, and patients suffering from this disease have a | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| THE VANDERBILT UNIVERSITY | $635,835 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposed research is to evaluate and validate the biological basis of emerging non-invasive imaging biomarkers for use in evaluation of treatment response in colorectal cancer (CRC). Current imaging criteria for evaluating therapeutic res | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $294,650 | Grant | Trans-NIH Recovery Act Research Support: Toll-like receptor (TLR) agonists have been shown to help generate potent antitumor T cell responses. Engagement of TLRs on antigen presenting cells (APCs), such as dendritic cells, induces the production of inflammatory cytokines, chemokines, as well as, | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| WESLEYAN UNIVERSITY | $770,688 | Grant | Trans-NIH Recovery Act Research Support: This application represents a request for support to conduct research integrating developmental theory regarding nicotine exposure and sensitivity with state-of-the-art statistical methods aimed at defining unique population subgroups at risk or nicotine | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $598,000 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this study is to elucidate the mechanisms of morphine and other opioid-induced tolerance in the ileum and brain but not in the colon which leads to constipation and limits the chronic use of these excellent pain relievers in man. This | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| DONALD DANFORTH PLANT SCIENCE CENTER | $602,266 | Grant | Trans-NIH Recovery Act Research Support: To date, only partial understanding of the formation of medicinal alkaloids at the enzyme and gene levels has been attained. In addition, the evolutionary origins of these biosynthetic pathways remain unsolved. The explosive increase in understanding of b | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $697,849 | Grant | Trans-NIH Recovery Act Research Support: The proposed study has two overarching aims: (1) to advance theory on the spatial dynamics of neighborhood exposure for understanding youthful health risk behavior; and (2) to model adolescent participation in high risk marijuana use (early onset and high | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| SUTTER WEST BAY HOSPITALS | $675,000 | Grant | Trans-NIH Recovery Act Research Support: Methamphetamine addiction remains a significant public health problem with no known effective pharmacotherapies. ARRA provided funding for a research project entitled G?Sustained Release Naltrexone for Methamphetamine Dependence: Role of the A118G SNPG?. | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| CREIGHTON UNIVERSITY | $694,185 | Grant | Trans-NIH Recovery Act Research Support: Role of microRNAs in mammalian ear development and neurosensory specification The purpose of this biomedical basic research grant is to investigate the function of genetic regulatory molecules termed microRNAs in the development and maintenance of sensor | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $2,890,606 | Grant | Trans-NIH Recovery Act Research Support: Brainstem stroke and amyotrophic lateral sclerosis can lead to devastating disability, resulting in part from communication impairment and immobility. In the most severe cases, patients become locked-in - awake and alert, but unable to move, control their | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF FLORIDA | $586,000 | Grant | Trans-NIH Recovery Act Research Support: We have discovered that the primary causative agent of human dental caries, Streptococcus mutans, undergoes major changes in gene expression and dramatically remodels its surface in response to exposure to oxygen. The goals of this research are to underst | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CINCINNATI | $719,514 | Grant | Trans-NIH Recovery Act Research Support: The goal of this research is to understand the mechanistic relationship between dietary lipid absorption and overall metabolism. The drug ezetimibe lowers plasma cholesterol by blocking its absorption in the intestine, apparently by disrupting the pathway | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $776,392 | Grant | Trans-NIH Recovery Act Research Support: The endoplasmic reticulum (ER) is a cellular organelle where secretory and membrane-associated proteins are synthesized and modified. It has been proposed that obesity promotes nutrient stress and chronic inflammation that involve increased demand on the | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,179,721 | Grant | Trans-NIH Recovery Act Research Support: Understanding Disparities In Obesity and Its Comorbidities In the U.S: The study is a systematic investigation to understand the individual-, family-, and community-level causes of ethnic/SES disparities in obesity and its comorbidities including type 2 d | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $1,066,948 | Grant | Trans-NIH Recovery Act Research Support: Obesity in childhood is increasing at an alarming rate. For children ages 2-5 years, the prevalence of overweight children has almost tripled over the last 30 years, from 5% to 13.9%, while the prevalence for children aged 6-11 years increased from 4% to | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| UNIVERSITY OF HOUSTON SYSTEM | $675,000 | Grant | Trans-NIH Recovery Act Research Support: A specialized population of cells known as podocytes plays a crucial and dynamic role in establishing and maintaining the glomerular filtration barrier. Indeed, mutations in three podocyte proteins that will be studied in this research G?? TRPC6, nephrin | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $591,993 | Grant | Trans-NIH Recovery Act Research Support: Alpha-1 antitrypsin (AAT) deficiency, due to the ?PiZZ? mutation, results in life-threatening lung and liver diseases in children and adults. Fortunately, the lung disease can be prevented by gene addition therapy. However, this strategy could not halt li | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| PALO ALTO INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $706,940 | Grant | Trans-NIH Recovery Act Research Support: Female urinary incontinence has been recently termed a silent epidemic, requiring systematic attention and a multidisciplinary approach towards economically ameliorating its impact. In this study we examine the role of the pelvic floor (PF) in maintainin | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,190,461 | Grant | Trans-NIH Recovery Act Research Support: This is a two-year AARA grant application that is aimed to develop, construct, and evaluate a prototype SPECT/MRI system for simultaneous high-resolution molecular SPECT/MR imaging of small animals, with the potential of further development into a human b | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| CREIGHTON UNIVERSITY | $216,750 | Grant | Trans-NIH Recovery Act Research Support: With the advent of modern engineered tissues for human transplant arises the need to improved tissue preservation technologies. In this regard, simple sugar solutions have proven to be effective in the long term preservation of biological tissues both co | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,428,909 | Grant | Trans-NIH Recovery Act Research Support: Improving our understanding of gene-environment interaction (GxE) as an etiologic mechanism in autism has been identified as a research priority in the NIH Inter-Agency Autism Coordinating Committee's (IACC's) Strategic Plan for Autism Spectrum | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| SMITH-KETTLEWELL EYE RESEARCH INSTITUTE, THE | $840,322 | Grant | Trans-NIH Recovery Act Research Support: We propose to develop and evaluate a cell-phone based system to enable blind and visually impaired individuals to find and read street signs and other signs relevant to wayfinding. Using the built-in camera and computing power of a standard cell phone, t | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF LOUISVILLE | $666,000 | Grant | Trans-NIH Recovery Act Research Support: Heterozygous mutations in the ZFHX1A zinc finger homeodomain transcriptional repressor in humans cause posterior polymorphous corneal dystrophy, a pathologic epithelization of the corneal endothelium. In mutant mice there are also epithelial vs. mesenchy | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,296,171 | Grant | Trans-NIH Recovery Act Research Support: These investigations will further define potential roles for new visual function tests and ocular imaging measures as potential outcomes for MS clinical trials, and will apply paradigms from MS vision research to acute ON as a more specific model for asse | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| DOHENY EYE INSTITUTE | $819,567 | Grant | Trans-NIH Recovery Act Research Support: Tissue damage in autoimmune disease has previously been attributed to T-cell and inflammatory cell infiltration and to the cytokines released thereafter. Activation of Toll-like receptors (TLRs) in innate immunity generates similar pro inflammatory cytoki | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $650,167 | Grant | Trans-NIH Recovery Act Research Support: Meiosis is a specialized cell division process, common to sexually reproducing eukaryotes, that reduces diploid zygotes to recombinant haploid gametes. Defects in meiosis have profound consequences for human health. More than half of human miscarriages re | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $577,594 | Grant | Trans-NIH Recovery Act Research Support: This work intends to survey specific RNAs associated with isolated membrane systems of cultured human cells. These RNAs are identified with specific sequences by array hybridization and massed sequencing. Identihed individual membrane-associated RNAs are | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $673,200 | Grant | Trans-NIH Recovery Act Research Support: The proliferation and differentiation of a stem/progenitor cell is important for building a tissue with the correct final size and cell compositions - too much proliferation may cause cancer, whereas too little proliferation will not generate the desired | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| WAYNE STATE UNIVERSITY (INC) | $429,811 | Grant | Trans-NIH Recovery Act Research Support: Mechanical forces influence a multitude of fundamental cellular processes, yet little is known about the mechanism. It is known that integrin receptors and focal adhesions are the nexus for mechano-communication and that input from the acto-myosin contrac | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $549,500 | Grant | Trans-NIH Recovery Act Research Support: Drug addition is a devastating disease affecting millions of people in the United States. The studies outlined in this proposal are aimed at identifying and characterizing novel components of the signaling pathways that underlie the molecular basis of dr | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE VANDERBILT UNIVERSITY | $785,052 | Grant | Trans-NIH Recovery Act Research Support: While the control of the tyrosine kinase activity of the EGF receptor is understood at certain levels, the contributions of the cytoplasmic juxtamembrane (JM) and carboxyterminal (CT) regions, which are adjacent to the kinase domain, are not clear. These | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $954,524 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project is to explore the regulatory mechanisms that control reproduction using a unique genetic model system, the hypogonadal, GnRH-deficient hpg mouse with replacement of GnRH by targeted gene therapy. The ultimate test for the | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| FLORIDA STATE UNIVERSITY, THE | $1,939,617 | Grant | Trans-NIH Recovery Act Research Support: Scientific activities will be conducted over the two-year project period to address the following specific aims: Aim 1. To study cutoff points and estimate sensitivity and specifity for the ESAC, SORF, and ADOS-Toddler in relation to a best estimate diagn | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF ROCHESTER | $690,750 | Grant | Trans-NIH Recovery Act Research Support: Congenital diaphragmatic defects are common birth defects with high morbidity and mortality secondary to associated pulmonary hypoplasia. Despite the significant impact that these defects have, the molecular mechanisms underlying their development are not | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $960,283 | Grant | Trans-NIH Recovery Act Research Support: Findings from survey studies indicate that the average American adult obtains an inadequate amount of sleep. Chronic sleep loss contributes to accidents and related deaths, poor job/school performance and poor health. In regards to health, short sleep dur | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $1,967,319 | Grant | Trans-NIH Recovery Act Research Support: Peripheral arterial disease (PAD) is a highly prevalent, frequently morbid manifestation of systemic atherosclerosis, but relatively little attention has been paid to the epidemiology and risk factors for PAD. Endothelial dysfunction and its relationship | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| BLOODCENTER OF WISCONSIN, INC. | $1,173,330 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the work in this proposal is to explore the membrane interactions of rap1b in more detail in order to better understand its mechanism of action. These findings will provide insight into how the body heals bleeding injuries, as well as the u | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF OKLAHOMA | $805,785 | Grant | Trans-NIH Recovery Act Research Support: Phage-Inspired Nanoparticles with Genetically Tunable Target-Specificity Abstract Non-viral gene therapy holds promise for treating both genetic and acquired diseases such as myocardial ischemia, osteosarcoma, atherosclerosis, cystic fibrosis, and corneal | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $1,625,296 | Grant | Trans-NIH Recovery Act Research Support: Novel non-invasive imaging tests have been developed to characterize atherosclerotic plaque burden and metabolic activity (inflammation). However, the value of these atherosclerosis imaging technologies for predicting coronary heart disease (CHD) and str | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| ALBERT EINSTEIN COLLEGE OF MEDICINE | $58,908 | Grant | Trans-NIH Recovery Act Research Support: This work develops and applies new advanced methods of imaging, or 'seeing', the structures of proteins and how they work, very much in the spirit of the development of, for example, magnetic resonance imaging methods developed in the last century. The fr | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $258,849 | Grant | Trans-NIH Recovery Act Research Support: Given the high incidence of bone trauma, cancer, and adult and congenital disease, which is associated with over 500,000 bone graft procedures each year in North America, it is not surprising that bone is the most common transplanted tissue, second only t | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| TRUSTEES OF CLARK UNIVERSITY | $152,000 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to investigate the unique strengths and potential challenges of lesbian couples across the transition to adoptive parenthood. Given that parental mental health has implications for child development, and the fact that adoption | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| RAND CORPORATION, THE | $168,586 | Grant | Trans-NIH Recovery Act Research Support: This project examines the effects of state child safety seat laws for children aged 4-9 on 1) children being restrained in child safety seats, and 2) child fatalities and injuries. We combine three publicly-available date sets to examine these issues at t | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF THE SCIENCES IN PHILADELPHIA | $223,780 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this investigation is to research and develop a novel macromolecular delivery system for anticancer drugs to produce greater anti tumor efficacy and less toxicities compared to non-biodegradable polymer delivery systems as well as to | Health and Human Services, Department of / National Institutes of Health | 5/12/2009 |
| FAIRFIELD UNIVERSITY | $219,395 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of the proposed research is to develop a novel noninvasive diagnostic and prognostic tool for microscopic imaging of the superficial layer of tissue. The proposed technique, low coherence enhanced backscattering tomography (LEBT), | Health and Human Services, Department of / National Institutes of Health | 7/02/2009 |
| MARQUETTE UNIVERSITY | $218,337 | Grant | Trans-NIH Recovery Act Research Support: Because enzymes often bind two substrates cooperatively, it may be difficult to design inhibitors that span both binding sites, using fragment assembly methods. While fragment assembly strategies exploiting a single binding site have yielded many high aff | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| WASHINGTON UNIVERSITY, THE | $266,000 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the exploratory R21 program studies (R21 AI 078237) proposed here is to better understand how the gastric pathogen Helicobacter pylori (Hp) evolves in human populations especially the impact of genetic drift and selection on genes impo | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| WISTAR INSTITUTE OF ANATOMY & BIOLOGY | $467,428 | Grant | Trans-NIH Recovery Act Research Support: The identification of a small subset of HIV-1 infected subjects that exhibit spontaneous control of viral replication (VL<75 copies RNA/mL) in the absence of anti-retroviral therapy (elite controllers) has heightened interest in the mechanism(s) of immune | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| WASHINGTON UNIVERSITY, THE | $410,022 | Grant | Trans-NIH Recovery Act Research Support: Our objective is to measure spatial, temporal, and directional variations in mechanical properties of the ferret brain during cortical folding. Disturbances of folding have serious and lasting consequences, but the mechanism is not understood. Van Essen ( | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $430,753 | Grant | Trans-NIH Recovery Act Research Support: ATM regulates many cellular processes including DNA damage responses and DNA double-strand break (DSB) repair in addition to responses involving oxidative stress and cell growth. Many of the processes ATM are associated with that are triggered by radiatio | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| HEALTH RESEARCH, INC. | $328,275 | Grant | Trans-NIH Recovery Act Research Support: Cyanide (CN = HCN + CN-) is a ubiquitous environmental toxicant. Despite a plethora of studies, little is known of its potential to cause adverse health effects. CN exposure is normally determined from blood by a GC-MS headspace assay. However, CN is rapi | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| PURDUE UNIVERSITY | $408,637 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: While manganese (Mn) is an essential trace metal, excess exposure due to occupational settings can cause damage to the nervous system. Symptoms of Mn intoxication ('manganism') resemble those in idiopathic Parkinson's disease and usually beco | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| NORTHWESTERN UNIVERSITY | $687,948 | Grant | Trans-NIH Recovery Act Research Support: Platelets are transfused for a wide range of thrombotic deficiencies, but there are problems. Platelet collection typically requires pooling harvests from multiple donors. Platelet transfusion risks from bacterial contamination, blood-borne pathogens, and | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $901,214 | Grant | Trans-NIH Recovery Act Research Support: This application will investigate how the transcriptional coactivator, Myocardin, regulates the differentiated state of the heart and the capacity of the heart to respond to hemodynamic stress. We have generated genetically altered mice with cardiac restr | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| MICHIGAN STATE UNIVERSITY | $749,369 | Grant | Trans-NIH Recovery Act Research Support: Macrophages are important immune cells involved in the pathogenesis of many inflammatory diseases, including atherosclerosis and are one of the major immune cells in the atherosclerotic lesions. In addition to becoming foam cells upon uptake of modified l | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CHICAGO, THE | $1,416,362 | Grant | Trans-NIH Recovery Act Research Support: The overall aim of this application is to understand the fundamental basis of the interaction of local anesthetic/ antiarrhythmic drugs (LA) with the cardiac voltage-gated sodium (Na) channel (NaV1.5). Our multiple-PI format brings together the strengths | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $1,114,299 | Grant | Trans-NIH Recovery Act Research Support: RhoGDI is a key regulator of both the Rho GTPase GDP/GTP activity cycle and the cytosol/membrane localization cycle. Our current understanding of RhoGDI regulation and the dynamics of its interactions with Rho GTPases during in vivo cell signaling remains | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| DUKE UNIVERSITY | $585,000 | Grant | Trans-NIH Recovery Act Research Support: Millions of Americans develop chest pain suggestive of coronary heart disease each year and often require non-invasive diagnostic testing. However, currently available tests are imprecise, robust evidence regarding optimal test choice is limited, and test | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| DUKE UNIVERSITY | $2,202,608 | Grant | Trans-NIH Recovery Act Research Support: Millions of Americans develop chest pain suggestive of coronary heart disease each year and often require non-invasive diagnostic testing. However, currently available tests are imprecise, robust evidence regarding optimal test choice is limited, and test | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $889,583 | Grant | Trans-NIH Recovery Act Research Support: Lack of well-phenotype samples remains a key bottleneck in biomedical research. The costs associated with collection often exceed those associated with any other step in the discovery process. The Crimson application addresses these issues by enabling hig | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $1,144,741 | Grant | Trans-NIH Recovery Act Research Support: This project seeks to identify Oxytocin and Vasopressin ligands that act via the CNS. It is well documented that such molecules would have potential application in disorders such as the pervasive developmental disorders such as Autism and Asperger's as s | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| SAINT LOUIS UNIVERSITY | $561,746 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this research is to establish the stress response in Drosophila as a model that can be utilized to elucidate how gender and sexual maturity affect recruitment of individual neurons into functioning neuronal circuits. | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| OREGON STATE UNIVERSITY | $1,452,624 | Grant | Trans-NIH Recovery Act Research Support: The ongoing HIV/AIDS and sexually transmitted infection (STI) epidemics in the United States require a strong, effective, and sustained public health response. Interventions delivered in public health venues and community-based organizations have the pote | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF PITTSBURGH THE | $886,708 | Grant | Trans-NIH Recovery Act Research Support: One-half of all depressed patients present for treatment with serious and distressing symptoms of anxiety or panic. Patients whose depression is complicated by co-existing anxiety features display a more severe and recurrent form of depression, poorer wor | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $1,773,901 | Grant | Trans-NIH Recovery Act Research Support: Although autism spectrum disorders (ASDs) are highly heritable, ASDs are heterogeneous, and no single genetic cause contributes to ASDs in a large proportion of patients. Instead, heterogeneous genetic changes, including many single gene mutations and cop | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $1,115,419 | Grant | Trans-NIH Recovery Act Research Support: This proposal is to support a collaboration between the laboratories of John Allman and Barbara Wold to investigate gene expression in laser micro-dissected cell populations in autopsy brains of well-phenotyped autistic individuals versus age and sex mat | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $1,248,025 | Grant | Trans-NIH Recovery Act Research Support: Although heterogeneity inherent in Autism Spectrum Disorders (ASDs) has long been recognized, little is known about ways in which race, gender, socio-economic status, family culture and communication during clinical encounters affect the acquisition of di | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| THE VANDERBILT UNIVERSITY | $5,196,989 | Grant | Trans-NIH Recovery Act Research Support: The root causes of autism remain unknown, limiting efforts to understand disease heterogeneity, diagnose cases, and prevent and treat disease. Epidemiological findings have repeatedly and unequivocally determined that heritable variation in DNA plays a su | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF PITTSBURGH THE | $616,867 | Grant | Trans-NIH Recovery Act Research Support: Title: FMRI Examination of Working Memory after TBI Each year, over 230,000 people survive moderate and severe traumatic brain injury (TBI). As a result, a large number of individuals with TBI endure life-long impairment and disability. Memory disturba | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REHABILITATION INSTITUTE OF CHICAGO | $844,600 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to develop a deeper understanding of the mechanisms that allow reorganization of motor functions, and to identify means of exploiting these adaptive mechanisms to facilitate training of novel hand movements. Movement reorgan | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| GEORGETOWN UNIVERSITY (THE) | $892,271 | Grant | Trans-NIH Recovery Act Research Support: Parkinson's disease is a slowly progressive degenerative disorder with classic motor symptoms that include resting tremor, cogwheel rigidity and bradykinesia. The disease produces invariant loss of dopamine neurons in the substantia nigra (SN) with the ha | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $841,500 | Grant | Trans-NIH Recovery Act Research Support: Alzheimer's Disease (AD) is an age-associated dementia for which there is currently no cure. AD is characterized by memory deficits, loss of CNS neurons, and eventually death. One of the prominent events in AD is the central nervous system (CNS) presence | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $1,508,834 | Grant | Trans-NIH Recovery Act Research Support: any neurological disorders, including hydrocephalus, result in brain injury and dysfunction in part through decreased cerebral blood flow (CBF). Evidence from clinical and experimental studies indicates that reduced CBF may be, in part, caused by impaired | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $746,529 | Grant | Trans-NIH Recovery Act Research Support: The axon's growing tip, the nerve growth cone advances by amoeboid locomotion, a process that involves concerted regulation of the actin cytoskeleton and cell adhesion. Growth cone adhesion is not well understood, but recent data indicate that amyloid pre | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $694,815 | Grant | Trans-NIH Recovery Act Research Support: NMDA receptors (NMDARs) are one of two major types of ion channels located in the postsynaptic membrane at the vast majority of excitatory synapses in the CNS. They not only mediate excitation but, because of their permeability to calcium, raise intracell | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $452,638 | Grant | Trans-NIH Recovery Act Research Support: Parkinson?s disease (PD) is the second most common neurodegenerative disease. Mutations in Leucine-rich-repeat-kinase 2 (LRRK2), the newly identified causative gene for PARK8 type PD with autosomal dominant inheritance, are the MOST PREVALENT genetic caus | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| YALE UNIVERSITY | $158,175 | Grant | Trans-NIH Recovery Act Research Support: The transmission of group B streptococcus from colonized women to their newborns during labor can be attenuated by treating women with intravenous antibiotic during labor. Current protocols from the CDC direct invasive testing and intensified surveillance | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $131,709 | Grant | Trans-NIH Recovery Act Research Support: There has been a growing interest in investigating genetic architecture of time-varying functional traits such as blood pressure, cholesterol levels or growth rate. Few of the methods proposed in the literature, however, are sufficiently general to apply | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| UNIVERSITY OF NEW MEXICO | $150,000 | Grant | Trans-NIH Recovery Act Research Support: This award supports computational research on the catalytic mechanism of arginine deiminase from bacteria and parasites. The objectives of the research is better understand how the enzyme accelerate the reaction and how molecules can be designed to block | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| COLORADO STATE UNIVERSITY | $147,000 | Grant | Trans-NIH Recovery Act Research Support: The emergence of multi-drug resistant (MDR) strains of Mycobacterium tuberculosis has led to a critical need for new therapeutic agents against tuberculosis. M. tuberculosis is endowed with a diverse range of glycosylphosphatidylinositides such as phospha | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| ST JOHN'S UNIVERSITY, NEW YORK | $163,500 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to identify the enzymes implicated in phosphatidylcholine biosynthesis from the precursor phosphatidylethanolamine in the human parasite Leishmania, to assess their importance in Leishmania viability, and to establish how the | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $149,500 | Grant | Trans-NIH Recovery Act Research Support: Mast cell involvement in most allergic events typically occurs due to IgE-mediated activation of such cells. However, recent progress reveals that mast cells play important roles in innate as well as acquired immunity. Complement activation also occurs du | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $157,000 | Grant | Trans-NIH Recovery Act Research Support: We propose to isolate a new generation of antibiotics that would be ideal for treating multi-drug resistant and otherwise difficult to treat infections. The antibiotics isolated could also have implications in emergency situations including treating victi | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $104,002 | Grant | Trans-NIH Recovery Act Research Support: The goal of this work is to produce a platform for studying bacterial group behavior under controlled environmental conditions, allowing fundamental questions to be investigated regarding the onset and maintenance of states corresponding to virulence and | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $153,000 | Grant | Trans-NIH Recovery Act Research Support: Pseudomonas aeruginosa infection is the major cause of morbidity and mortality in cystic fibrosis. The organism persists in airways in large part through its ability to generate energy under the oxygen-limited conditions that define the dehydrated mucus | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| NORTHWESTERN UNIVERSITY | $152,233 | Grant | Trans-NIH Recovery Act Research Support: Rheumatoid arthritis (RA) is an autoimmune disease, which is associated with hyperproliferation and increased invasiveness of synovial fibroblasts (SFs), leading to joint damage. The mechanisms underlying SF cell transformation in RA remain poorly underst | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF KENTUCKY | $167,146 | Grant | Trans-NIH Recovery Act Research Support: Health literacy has emerged as an important construct because it's four components: cultural and conceptual knowledge, listening and speaking (oral literacy), writing and reading (print literacy), and numeracy affect the health outcomes of individuals. As | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| GEORGIA TECH RESEARCH CORPORATION | $143,362 | Grant | Trans-NIH Recovery Act Research Support: Autophagy is a promising new target for cancer chemoprevention and chemotherapy because it has the potential to prevent, reverse, or retard progression of precancerous lesions as well as to kill tumor cells by ''type II'' or ''autophagic'' cell death. Ind | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $142,950 | Grant | Trans-NIH Recovery Act Research Support: As patients with advanced cancer approach the end of life (EOL), the family becomes a crucial resource. Facing multiple caregiving demands, family members are at risk for higher rates of depression and anxiety during this phase of illness. Family Focused | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| EASTERN VIRGINIA MEDICAL SCHOOL | $143,500 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer is the most common form of cancer in males within the United States. Innovative strategies are required to aid in the diagnosis and treatment of prostate cancer as well as to elucidate the underlying mechanisms leading to this prevalent di | Health and Human Services, Department of / National Institutes of Health | 6/09/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $164,698 | Grant | Trans-NIH Recovery Act Research Support: This study will determine the validity of a mother's self-reported events around pregnancy by comparing that data to her medical record and then use the predictive values to adjust the odds ratio estimates from the maternal interview for misclassification | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CANCER PREVENTION INSTITUTE OF CALIFORNIA | $145,000 | Grant | Trans-NIH Recovery Act Research Support: Epidemiologic evidence is accumulating that early-life factors may play an important role in the development of breast cancer. Early in life and in adolescence, girls may be particularly sensitive to exposures that are associated with breast cancer initia | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF MONTANA SYSTEM | $132,788 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this proposed study is to utilize readily available administrative medical claims data for a commercially-insured population to both characterize and develop a model for predicting the probability of opioid misuse. The predictive natrue of | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF PITTSBURGH THE | $227,250 | Grant | Trans-NIH Recovery Act Research Support: Previous studies using PET and SPECT endogenous competition binding techniques have shown that chronic cocaine users relative to healthy controls release less dopamine following an acute amphetamine challenge. A likely explanation for a decrease in DA tra | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |