Recovery Tracker

How Much Stimulus Funding is Going to Your County?

Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page

Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.

Recipient Amount Type Description Federal Dept./Agency Date
UNIVERSITY OF CINCINNATI $499,238 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Intravital confocal imaging often requires multiple fluorescent markers with similar spectral properties, the ability to capture highly dynamic events, and stringent specimen environmental needs. Specialized instrument Health and Human Services, Department of / National Institutes of Health 5/13/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $177,422 Grant Trans-NIH Recovery Act Research Support: Our long-term objective is to enlarge the scope and efficiency of clinical research through enhanced use of clinical data to support clinical research decisions. This proposal aims to improve the use of electronic health records (EHR) to automate clinical Health and Human Services, Department of / National Institutes of Health 5/25/2010
CHARLES DREW UNIVERSITY OF MEDICINE AND SCIENCE $94,673 Grant Trans-NIH Recovery Act Research Support: Charles R. Drew University of Medicine and Science (Drew) proposes to continue and enhance its Drew National High School Student Summer Research Apprentice Program (NHSSSRAP). The main goal is to increase the number of underrepresented minority and disadv Health and Human Services, Department of / National Institutes of Health 5/21/2010
AMERICAN COLLEGE OF RADIOLOGY, THE $392,236 Grant Trans-NIH Recovery Act Research Support: The American College of Radiology Imaging Network (ACRIN) was established as a consortium to generate, execute and report on multicenter clinical trials in imaging as it relates to cancer. ACRIN, like other NCI funded cooperative research groups, has note Health and Human Services, Department of / National Institutes of Health 5/27/2010
UTAH STATE UNIVERSITY $397,057 Grant Trans-NIH Recovery Act Research Support: Descriptive title: Dietary patterns, cognition and Alzheimer?s Disease: the Cache County Study. The etiology of Alzheimer?s Disease (AD), now the third most costly medical condition in the U.S., is likely influenced by diet. Several nutrients and or foo Health and Human Services, Department of / National Institutes of Health 3/31/2010
DIGICON CORPORATION $107,768 Contract : Bar Code Device Support Services Health and Human Services, Department of / National Institutes of Health 4/12/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $89,800 Grant Trans-NIH Recovery Act Research Support: Critical illness and injury are leading causes of death and disability world- wide. Despite our nation's expertise and the imperative to improve outcomes for the critically ill and injured, the US does not have a federally-funded critical care research ne Health and Human Services, Department of / National Institutes of Health 5/04/2010
UNIVERSITY OF TEXAS AT AUSTIN $171,274 Grant Trans-NIH Recovery Act Research Support: We are requesting funds to purchase an instrument (KinExA) with the ability to sensitively and precisely measure binding kinetics from the millimolar to picomolar ranges and to quantify femptomolar concentrations of molecules of interest in complex soluti Health and Human Services, Department of / National Institutes of Health 5/20/2010
SCIENCE APPLICATIONS INTERNATIONAL CORPORATION $64,000 Contract : Provide software development and support services to the NIH Office of Extramural Research (OER) for the Electronic Research Administration (eRA) systems and databases with respect to ARRA grant recipient reporting. At the beginning of each quarter, coll Health and Human Services, Department of / National Institutes of Health 6/01/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $79,633 Grant Trans-NIH Recovery Act Research Support: The T3SS of P. aeruginosa delivers potent enzymes that modulate cell physiology. Expression of the toxins correlates with increased tissue damage, the spread of the bacterium from local sites to the bloodstream and high mortality rates. The P. aeruginosa Health and Human Services, Department of / National Institutes of Health 5/17/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $44,804 Grant Trans-NIH Recovery Act Research Support: The requested supplement includes funds for the purchase of a critical research instrument (an FPLC system) and stable istopes, and will accelerate the pace of scientific research on the interaction of HIV-1 capsid protein with human cyclophilin A. The pu Health and Human Services, Department of / National Institutes of Health 6/01/2010
ST. JUDE CHILDREN'S RESEARCH HOSPITAL $405,039 Grant Trans-NIH Recovery Act Research Support: The primary mission of St. Jude Children's Research Hospital is to find cures for children with cancer and other catastrophic diseases through research and treatment. Recent progress at St. Jude has provided a better understanding of the molecular, geneti Health and Human Services, Department of / National Institutes of Health 4/22/2010
UNIVERSITY OF WASHINGTON $499,950 Grant Trans-NIH Recovery Act Research Support: The enclosed proposal is requesting funds to expand the mass spectrometry and proteomics resources at the University of Washington through the purchase of a Thermo Fisher LTQ-Orbitrap mass spectrometer. This instrument will be invaluable in the successfu Health and Human Services, Department of / National Institutes of Health 5/13/2010
GEORGE MASON UNIVERSITY $409,190 Grant Trans-NIH Recovery Act Research Support: Statistical Methods in Cancer Research: development of statistical methodology for studies of cancer DESCRIPTION: A team of biostatistical methodologists propose to develop new methodology for the statistical analysis of cancer data and cance Health and Human Services, Department of / National Institutes of Health 5/20/2010
THE VANDERBILT UNIVERSITY $218,186 Grant Trans-NIH Recovery Act Research Support: Purchase of a Episcopic Fluorescence Image Capture System (EFIC) from Vashaw Scientific is proposed. This instrument will serve the research programs of four major users distributed among several departments on campus. The development of new EFIC projects Health and Human Services, Department of / National Institutes of Health 4/15/2010
UNIVERSITY OF UTAH, THE $166,336 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): We propose to purchase a Zeiss microinjection station for use in the University of Utah Transgenic and Gene Targeting Mouse Core. This core facility is heavily used by NIH- funded investigators, and has contributed to Health and Human Services, Department of / National Institutes of Health 4/22/2010
TUFTS MEDICAL CENTER PARENT, INC. $493,500 Grant Trans-NIH Recovery Act Research Support: This grant was requested for the funding of a Genome Sequencer (GS) FLX and the GS FLX Computer Cluster required for its dedicated software applications. In an overnight run, this equipment can generate over a million sequence reads at an average read-len Health and Human Services, Department of / National Institutes of Health 6/10/2010
THE VANDERBILT UNIVERSITY $489,387 Grant Trans-NIH Recovery Act Research Support: We request funds to purchase a shared FEI Quanta 250 FEG Scanning Electron Microscope (SEM). At present, the only SEM available at Vanderbilt is one maintained by the College of Engineering and used primarily for materials science applications. Use of th Health and Human Services, Department of / National Institutes of Health 5/13/2010
JOHNS HOPKINS UNIVERSITY, THE $492,000 Grant Trans-NIH Recovery Act Research Support: Description remains unchanged. Diabetes is a leading cause of cardiovascular disease, end-stage renal disease, blindness and debilitating neuropathies. Hyperglycemia is the root cause of these maladies, but the mechanisms of glucose toxicity are unclear. Health and Human Services, Department of / National Institutes of Health 4/05/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $144,107 Grant Trans-NIH Recovery Act Research Support: This instrumentation proposal is for the Eclipse 90i Motorized Advanced Research Microscope (Nikon Instruments, Melville, NY, USA) with OSTEO 2009 Bone Biology Research System Software (BIOQUANT Image Analysis Corporation, Nashville, TN, USA). The propos Health and Human Services, Department of / National Institutes of Health 5/13/2010
SOUTHERN ILLINOIS UNIVERSITY $189,843 Grant Trans-NIH Recovery Act Research Support: This award was used to purchase one MicroBrightField Bioscience Imaging System which will be used by faculty members from at least three departments: Pharmacology, Internal Medicine and Surgery. This system will benefit the quality of research at SIU by Health and Human Services, Department of / National Institutes of Health 5/20/2010
UNIVERSITY OF WASHINGTON $500,000 Grant Trans-NIH Recovery Act Research Support: DNA sequence represents a single format upon which a broad range of biological phenomena (e.g. genetic variation, RNA expression, protein-DNA interactions, chromosome conformation, etc.) can be projected for high-throughput data collection. Over the past Health and Human Services, Department of / National Institutes of Health 4/29/2010
SOCIAL & SCIENTIFIC SYSTEMS, INC. $259,237 Grant Trans-NIH Recovery Act Research Support: This project is an administrative supplement for the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Group, specifically for additional work under protocols P1086 and P1088. Health and Human Services, Department of / National Institutes of Health 5/24/2010
PIASEK BIOTECH INC $197,430 Grant Trans-NIH Recovery Act Research Support: Sleep apnea is a disorder that affects millions of Americans in which a person stops breathing during sleep for 10 seconds or longer. These episodes are known as apneas. People who have a severe form of sleep apnea can have hundreds of such episodes per h Health and Human Services, Department of / National Institutes of Health 5/05/2010
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK $464,091 Grant Trans-NIH Recovery Act Research Support: This proposal requests funds for the purchase of a Leica TCS SP5 confocal microscope. The Leica TCS SP5 is a single point broadband confocal modular platform equipped with an RGB (HeNe 633nm, HeNe 594nm, HeNe 543, Argon 458/476/488/496/514) and a UV-diode Health and Human Services, Department of / National Institutes of Health 5/20/2010
VWR INTERNATIONAL, LLC $7,202 Contract : PO for Laboratory supplies under solicitation RML-RFQ-10008 vbq-3590877. Health and Human Services, Department of / National Institutes of Health 5/21/2010
UNIVERSITY OF CALIFORNIA, DAVIS $3,103,983 Grant Trans-NIH Recovery Act Research Support: Neuroscience investigators on the main Campus at the University of California, Davis, are internationally recognized leaders in research designed to understanding the cognitive and developmental processes that are altered in serious mental and neurologica Health and Human Services, Department of / National Institutes of Health 5/20/2010
UNIVERSITY OF WISCONSIN SYSTEM $499,443 Grant Trans-NIH Recovery Act Research Support: This project is a request for a Recovery Act Administrative Supplement under Notice Number (NOTOD-09-056). The supplement is designed to further the original aims of the parent grant (P41RR02301), which supports the National Magnetic Resonance Facility at Health and Human Services, Department of / National Institutes of Health 6/10/2010
UNIVERSITY OF MARYLAND $7,994,900 Grant Trans-NIH Recovery Act Research Support: NIH-funded principal investigators at the University of Maryland, Baltimore (UMB), the University of Maryland, Baltimore County (UMBC), and the University of Maryland, College Park (UMCP) have scientific need for a state-of-the-art shielded 950 MHz NMR be Health and Human Services, Department of / National Institutes of Health 5/27/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $314,128 Grant Trans-NIH Recovery Act Research Support: This research stands to improve the understanding of how emotional factors can influence cognitive function, and also how this influence might change with aging. The possibility that voluntary cognitive operations performed on 'positive' information migh Health and Human Services, Department of / National Institutes of Health 4/05/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $500,000 Grant Trans-NIH Recovery Act Research Support: The Imaging Core of the Cleveland Clinic Lerner Research Institute and a group of fifteen NIH- funded investigators request funds to purchase a spinning disk confocal microscope system for live-cell imaging - specifically the Perkin Elmer Ultraview Vox Sy Health and Human Services, Department of / National Institutes of Health 5/27/2010
UNIVERSITY OF LOUISIANA AT MONROE $213,000 Grant Trans-NIH Recovery Act Research Support: Hindbrain Glucoprivis Regulation of the HPG Axis - Fundamental understanding of the molecular mechanism governing osteoblast differentiation is essential for developing novel therapeutics for osteoporosis and bone fracture. Transglutaminases TG2 and FXIII Health and Human Services, Department of / National Institutes of Health 4/12/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $668,878 Grant Trans-NIH Recovery Act Research Support: The overall intent - STREAMLINED MUTATION DETECTION OF SKIN CANCER BIOSPECIMENS, a platform built around pyrosequencing to; expedite in time the process of performing mutation detection, ensure quality control, reduce costs, and expand the number of sampl Health and Human Services, Department of / National Institutes of Health 4/14/2010
UNIVERSITY OF KENTUCKY $907,883 Grant Trans-NIH Recovery Act Research Support: The Proteomics Core Facility at the University of Kentucky (UK) College of Medicine requests $947,163 to acquire a LTQ Orbitrap XL/ETD hybrid mass spectrometer with an Eksigent nano-HPLC. The goal of this application is to provide advanced mass spectromet Health and Human Services, Department of / National Institutes of Health 6/10/2009
MEDICAL COLLEGE OF WISCONSIN, INC., THE $312,800 Grant Trans-NIH Recovery Act Research Support: The supplement is specifically designed to enhance the activities of the parent grant and its specific aims which are to: 1) Delineate the underlying genetic and cellular causes of childhood renal disease and its progression through two projects and two Health and Human Services, Department of / National Institutes of Health 8/11/2009
JOHNS HOPKINS UNIVERSITY, THE $136,594 Grant Trans-NIH Recovery Act Research Support: The Multicenter AIDS Cohort Study (MACS), a comprehensive cohort study ongoing since 1984, has contributed to the understanding of the natural history of HIV infection and the impact of highly active antiretroviral therapies (HAART). Combining genetic, vi Health and Human Services, Department of / National Institutes of Health 6/02/2010
UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON $272,525 Grant Trans-NIH Recovery Act Research Support: Evaluation of safety and efficacy of microbicides requires an assessment of potential injury caused by micobicides in the epithelium of cervicovaginal tract and rectum. The development of imaging technology and protocols that can be used for endoscopic, r Health and Human Services, Department of / National Institutes of Health 6/09/2010
MOUNT SINAI SCHOOL OF MEDICINE $39,013 Grant Trans-NIH Recovery Act Research Support: Our long-term goal is to elucidate the molecular mechanisms by which thyroid stem cells differentiate into definitive thyrocytes. We specifically focus on thyroid stimulating hormone (TSH), as it is the major hormone in the control of thyroid growth and f Health and Human Services, Department of / National Institutes of Health 4/05/2010
NEW YORK UNIVERSITY (INC) $38,577 Grant Trans-NIH Recovery Act Research Support: This supplement supports a summer research experience for one undergraduate student and one science teacher. A fundamental question, now that the human genome sequence has been elucidated, is to understand how it directs complex biological and developmen Health and Human Services, Department of / National Institutes of Health 4/14/2010
SUTTER WEST BAY HOSPITALS $7,738 Grant Trans-NIH Recovery Act Research Support: Th.e Scope of Work for the project remains essentially unchanged. There will still be 3 Specific Aims: Specific Aim 1 G?? Optimize SFHR frequency by testing different sizes and types (single versus double stranded) of fragment, Specific Aim 2 G??Determin Health and Human Services, Department of / National Institutes of Health 4/30/2010
MONTEFIORE MEDICAL CENTER $1,546,761 Grant Trans-NIH Recovery Act Research Support: 1) HIV Tropism as a potential Biomarker for Atherosclerosis: This project investigates whether a property of HIV called 'tropism' can predict which HIV-infected individuals are at high risk of developing cardiovascular disease. Identifying such a predi Health and Human Services, Department of / National Institutes of Health 4/28/2010
UNIVERSITY OF SOUTH ALABAMA $129,955 Grant Trans-NIH Recovery Act Research Support: THIS IS A REQUEST FOR ADMINISTRATIVE SUPPLEMENT FUNDS IN RESPONSE TO NOTICE NOT-OD-09-056 FOR MY CURRENT GRANT GENETIC ANAYLSIS OF RICKETTSIA PROWAZEKII (5 R37 AI020384-26). ADDITIONAL FUNDS ARE REQUESTED TO ENSURE 50% USE OF A FLOURESCENCE ACTIVATED CELL Health and Human Services, Department of / National Institutes of Health 4/12/2010
UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL $366,114 Grant Trans-NIH Recovery Act Research Support: Post-transcriptional regualtion of gene expression and the link between the translation elongation factor 1A (eEF1A) and the actin cytoskeleton and other actin associated proteins remains an area where little is known about mechanism or regulation. The o Health and Human Services, Department of / National Institutes of Health 7/15/2009
ALBANY MEDICAL COLLEGE $96,197 Grant Trans-NIH Recovery Act Research Support: This supplemental request is to upgrade our existing inverted microscope to a spinning disk confocal and to enable us to hire a recent Ph.D. graduate to bring cutting edge technology into the lab. These two requests are to enable us to be more productive Health and Human Services, Department of / National Institutes of Health 5/05/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $75,696 Grant Trans-NIH Recovery Act Research Support: The ultimate goal of this project is to identify genes influencing obesity related traits. This proposal requests support for genotyping SNPs in the overall sample in order to identify those newly discovered variants that segregate with obesity phenotype Health and Human Services, Department of / National Institutes of Health 6/18/2010
WESTERN WASHINGTON UNIVERSITY $389,288 Grant Trans-NIH Recovery Act Research Support: This project aims to use structure-based computational protien design and x-ray crystallography to better understand the stability of the factor VIII C2 domain and the nature of its interactions with 'nonclassical' antibody inhibitors. Additionally, we p Health and Human Services, Department of / National Institutes of Health 4/30/2010
UNIVERSITY OF WISCONSIN SYSTEM $234,679 Grant Trans-NIH Recovery Act Research Support: Sewage contamination in the Great Lakes is a major environmental and human health threat. The five Laurentian Great Lakes have over 1000 recreation beaches and serve as a drinking water source to 40 million people. Sewage overflows introduce complex micro Health and Human Services, Department of / National Institutes of Health 4/19/2010
UNIVERSITY OF MISSOURI SYSTEM $353,473 Grant Trans-NIH Recovery Act Research Support: The primary objective of this project is to examine factors that are associated with the effectiveness of intervention programs designed to reduce high-risk drinking among heavy drinking college students. Previous research has found similar effect sizes f Health and Human Services, Department of / National Institutes of Health 9/09/2009
METROPOLITAN ARCHITECTS AND PLANNERS INC $3,000,000 Contract : Support the review of drawings and documents for ARRA funded construction projects. Health and Human Services, Department of / National Institutes of Health 5/19/2010
CHARLES DREW UNIVERSITY OF MEDICINE AND SCIENCE $32,712 Grant Trans-NIH Recovery Act Research Support: With a longstanding history of collaborations in education, health services research and community service, Drew University, the only historically black medical school west of the Mississippi River, and UCLA, one of this nation's premier universities, are Health and Human Services, Department of / National Institutes of Health 5/11/2010
FRED HUTCHINSON CANCER RESEARCH CENTER $496,515 Grant Trans-NIH Recovery Act Research Support: There are two overall objectives for this ARRA award; 1. First to enlist and pay normal adults to serve as donors of CD34 cells for research purposes. The cells are made available to researchers from across the country for investigational studies. 2. Health and Human Services, Department of / National Institutes of Health 4/01/2010
PORTFOLIO MANAGEMENT CONSULTING, LLC $252,721 Contract : TAS::75 0845::TAS - RECOVERY ERA PROFESSIONAL MANAGEMENT SUPPORT - EVERGREENING PROJECT/ARCHIVE-PURGE RECORDS/ENHANCING PEER REVIEW PROJECT -- Health and Human Services, Department of / National Institutes of Health 6/03/2010
NIKON INSTRUMENTS INC. $40,799 Contract : Liquid cooled Evolve camera Health and Human Services, Department of / National Institutes of Health 5/29/2009
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $100,282 Grant Trans-NIH Recovery Act Research Support: Peripheral T cell tolerance versus autoimmunity Is determined by dendritic cell presentation of antigen. Our prior work, using foreign antigens, has shown that antibody-mediated enhancement of antigen presentation by dendritic cells induces potent effecto Health and Human Services, Department of / National Institutes of Health 4/12/2010
UNIVERSITY OF CONNECTICUT $98,163 Grant Trans-NIH Recovery Act Research Support: Bioactive peptides are among the most ancient methods for intercellular communication. Peptide amidation, the modification of the ionizable COOH-terminal of a peptide to have an uncharged amide group, requires a number of cofactors and presents a set of c Health and Human Services, Department of / National Institutes of Health 6/07/2010
RUSH UNIVERSITY MEDICAL CENTER $49,993 Grant Trans-NIH Recovery Act Research Support: Cell Therapy for the degenerating intervertebral discs--Our overall goal is to determine if cells overexpressing human bone morphogenetic protein 7 (hBMP-7) will help regenerate degenerating intervertebral discs (IVDs) in the rabbit disc degeneration mode Health and Human Services, Department of / National Institutes of Health 4/21/2010
HUNTINGTON MEDICAL RESEARCH INSTITUTES $153,535 Grant Trans-NIH Recovery Act Research Support: Multi-channel electrochemical measurement system. Multi-channel system to simultaneously obtain measurrements of cyclic voltametry and EIS (electical impedance spectroscopy) from multiple electrodes. Will cut data acquisition time to 1/10th of what it cu Health and Human Services, Department of / National Institutes of Health 3/25/2010
YALE UNIVERSITY $496,785 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Cell Biology is intimately linked with the ability to see organelles, vesicles, cytoskeleton and even single molecules inside cells, both in normal and diseased states. Instruments that allow biologists to see better, Health and Human Services, Department of / National Institutes of Health 6/10/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $311,181 Grant Trans-NIH Recovery Act Research Support: Award Title: Total Internal Reflection Fluorescence Microscope This ARRA award allows us to purchase a Total Internal Reflection Fluorescence (TIRF) microscope with the capability for imaging 3 and 4 spectrally distinct fluorophores near-simultaneously (< Health and Human Services, Department of / National Institutes of Health 5/20/2010
UNIVERSITY OF CALIFORNIA, DAVIS $499,785 Grant Trans-NIH Recovery Act Research Support: The ARRA award is an S10 grant to provide funding for a new LSRII flow cytometer. This will be a vital shared resource for the many investigators working on NIH-funded projects in our new Institute for Regenerative Cures. Health and Human Services, Department of / National Institutes of Health 1/25/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $36,734 Grant Trans-NIH Recovery Act Research Support: Articular cartilage is one of a number of tissues in the body that bears load and slides relative to an apposing tissue surface with remarkable tribological propertieslow friction, low wear, and multiple modes of lubrication acting to lower friction and/o Health and Human Services, Department of / National Institutes of Health 5/26/2010
UNIVERSITY OF MISSOURI SYSTEM $220,195 Grant Trans-NIH Recovery Act Research Support: Asthma has been increasing in prevalence and severity for unknown reasons. Though our understanding of the pathophysiology remains poor, it is widely accepted that asthma is an inflammatory disease and CD4+ T cells elaborating Th2 cytokines have been iden Health and Human Services, Department of / National Institutes of Health 6/28/2010
UNIVERSITY OF WASHINGTON $2,660,500 Grant Trans-NIH Recovery Act Research Support: We propose expanding NMR resources at the University of Washington(UW) by acquiring a 800 MHz. NMR spectrometer capable of performing both solution and solid state NMR experiments. The number of research groups in the Seattle area involved in performing Health and Human Services, Department of / National Institutes of Health 5/13/2010
DUKE UNIVERSITY $137,589 Grant Trans-NIH Recovery Act Research Support: Nasally administered vaccines have the potential to be effective, economical, needle-free methods of immunization able to induce both systemic and'mucosal immunity. Nasal immunization may allow for safe and effective vaccination against emerging infectiou Health and Human Services, Department of / National Institutes of Health 5/10/2010
UNIVERSITY OF OREGON $47,540 Grant Trans-NIH Recovery Act Research Support: We received an administrative supplement with ARRA funding to support a summer outreach research and training program. The supplement provided for opportunities for high school students, undergraduate students, and a high school teacher to immerse themse Health and Human Services, Department of / National Institutes of Health 4/14/2010
UNIVERSITY OF LOUISVILLE $89,550 Grant Trans-NIH Recovery Act Research Support: This award is a supplement to our existing NIH grant in order to purchase instrumentation (ELISPOT). The overall goal of the parent grant is to address the current limitations that prevent widespread clinical application of islet transplantation for dia Health and Human Services, Department of / National Institutes of Health 1/11/2010
VIRGINIA COMMONWEALTH UNIVERSITY $483,089 Grant Trans-NIH Recovery Act Research Support: Funds are requested to acquire a Zeiss Cell Observer SD (spinning disc) confocal microscope to support the research efforts of multiple NIH-funded investigators at Virginia Commonwealth University (VCU). This live cell / live tissue imaging system is to b Health and Human Services, Department of / National Institutes of Health 5/27/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $939,608 Grant Trans-NIH Recovery Act Research Support: This application requests funds to purchase an Olympus FV1000-MPE confocal and multi-photon fluorescence microscope imaging system dedicated to intravital microscopy in small animals. The intravital microscope system will be housed, managed, and maintaine Health and Human Services, Department of / National Institutes of Health 4/15/2010
UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE $474,288 Grant Trans-NIH Recovery Act Research Support: The Bioinformatics Research Center (BRC), together with the University Research Computing (URC) support group, at the University of North Carolina at Charlotte (UNC Charlotte) is requesting a high performance computing resource in support of numerous NIH- Health and Human Services, Department of / National Institutes of Health 4/01/2010
JOHNS HOPKINS UNIVERSITY, THE $350,350 Grant Trans-NIH Recovery Act Research Support: HIV/AIDS, tuberculosis (TB), malaria and trypanosomiasis are infectious diseases of major importance to international health causing tremendous disease burdens on populations globally. HIV, the greatest cause of death internationally, is pandemic with fat Health and Human Services, Department of / National Institutes of Health 5/20/2010
MISSOURI SYSTEM, UNIVERSITY OF $150,000 Grant Trans-NIH Recovery Act Research Support: We are seeking administrative supplement funding to expand the scope and validate the new scope of Specific Aim 4 within our Cancer Nanotechnology platform grant. Specific objective within the the current grant entails: Investigation on the utility of AuN Health and Human Services, Department of / National Institutes of Health 9/09/2009
OREGON HEALTH & SCIENCE UNIVERSITY $500,000 Grant Trans-NIH Recovery Act Research Support: The Oregon National Primate Research Center (ONPRC) maintains a free-standing, 2,500 sq. ft. magnetic resonance imaging (MRI) facility that is within 100 ft. of the ONPRC surgical space, and is dedicated to the study of nonhuman primate subjects. This arr Health and Human Services, Department of / National Institutes of Health 5/13/2010
SANOVICH, ELENA $7,590,000 Contract : Assist in the recruitment of scientific reviewers and prepare summary statements for the National Institute on Aging Health and Human Services, Department of / National Institutes of Health 5/10/2007
TRUSTEES OF INDIANA UNIVERSITY $492,387 Grant Trans-NIH Recovery Act Research Support: This Shared Instrumentation Grant is to purchase an Applied Biosystems SOLiD 4 System for high-throughput DNA sequencing. High-throughput sequencing is important to many ongoing research projects at the Indiana University School of Medicine examining the Health and Human Services, Department of / National Institutes of Health 5/20/2010
VISIONQUEST BIOMEDICAL LLC $2,884,862 Grant Trans-NIH Recovery Act Research Support: 'This project is motivated by the fact that comprehensive, broad-scale screening for eye diseases such as age-related macular degeneration (AMD) and diabetic retinopathy (DR) is economically prohibitive without the introduction of computer-assisted diagno Health and Human Services, Department of / National Institutes of Health 3/22/2010
INNOSENSE LLC $195,586 Grant Trans-NIH Recovery Act Research Support: G?Heart diseaseG? surpasses cancer as the leading cause of death in the United States. To better diagnose cardiovascular diseases and to accurately evaluate patient risk for such life-threatening conditions, Phase I efforts will focus on the characterizat Health and Human Services, Department of / National Institutes of Health 5/15/2010
THE INSTITUTE FOR CANCER RESEARCH $10,665 Grant Trans-NIH Recovery Act Research Support: Title: MHC Class I Antigen Presentation in Viral Infections Abstract: Funds are requested to support the work of one undergraduate student during the summer. The work of the student will be to screen for and characterize monoclonal antibodies that recog Health and Human Services, Department of / National Institutes of Health 5/24/2010
RESEARCH SOLUTIONS, INC $41,424 Contract : Ferret Cages Health and Human Services, Department of / National Institutes of Health 3/05/2010
UNIVERSITY OF FLORIDA $32,230 Grant Trans-NIH Recovery Act Research Support: Hyperoxaluria is considered a major risk factor in the genesis of calcium oxalate stone disease which occurs in about 12% of the U. S. population costing an estimated $2 billion annually. Oxalate homeostasis is governed by the amount of dietary oxalate ab Health and Human Services, Department of / National Institutes of Health 4/09/2010
UNIVERSITY OF TOLEDO, THE $196,617 Grant Trans-NIH Recovery Act Research Support: Award Description* Proinflammatory cytokines, such as TNF IL-1,IL-8, are produced by leukocytes in response to bacteria or their components. The inflammatory response involves leukocyte transcriptional activation and specific gene expression. Most studies Health and Human Services, Department of / National Institutes of Health 6/28/2010
UNIVERSITY OF MARYLAND $187,500 Grant Trans-NIH Recovery Act Research Support: Antibodies are highly useful reagents in biotechnological and biomedical applications, yet recombinant antibodies have their limitations. These include the complex architecture of their antigen-binding sites, which complicates the generation of synthetic Health and Human Services, Department of / National Institutes of Health 6/17/2010
UNIVERSITY OF KENTUCKY $84,965 Grant Trans-NIH Recovery Act Research Support: Covalent modification by isoprenoid lipids (prenylation) is a critical post-translational event for many proteins involved in cellular signaling and cancer. The primary goal of this research program is to design and test prenyl function inhibitors and to Health and Human Services, Department of / National Institutes of Health 5/10/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $2,709,858 Grant Trans-NIH Recovery Act Research Support: A Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer with exceptional sensitivity and ultra-high resolution for detecting peptides, proteins, and metabolites will be purchased. The new instrumentation will benefit a wide range of biomed Health and Human Services, Department of / National Institutes of Health 4/15/2010
CHILDREN'S HOSPITAL CORPORATION, THE $265,500 Grant Trans-NIH Recovery Act Research Support: Peripheral neuropathic pain arises from diverse changes in the peripheral and central nervous systems that include a reciprocal interaction between the immune and nervous systems. We find from a microarray expression profile analysis that immunologic gene Health and Human Services, Department of / National Institutes of Health 4/12/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $7,325 Grant Trans-NIH Recovery Act Research Support: The B1a (CD5+) B-cells are the primary producers of natural antibodies that are self-reactive and polyreactive but usually non-pathogenic. However, in some circumstances, B1a B-cells contribute substantially to the immunopathogenesis of chronic systemic a Health and Human Services, Department of / National Institutes of Health 5/24/2010
NEW YORK UNIVERSITY (INC) $57,000 Grant Trans-NIH Recovery Act Research Support: This supplement provides project support, both for personnel and equipment, to accelerate the pace of the research. This research will investigate how a protein hormone (parathyroid hormone, PTH) is able to interact with a cell's surface and transmit sig Health and Human Services, Department of / National Institutes of Health 4/08/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $30,400 Grant Trans-NIH Recovery Act Research Support: Develop and implement a Moodle-based application for on-line training, video conferencing among group members of all sites, and uploading and scoring of neuropsychological data. In addition, to develop and implement a cell phone based data entry port as Health and Human Services, Department of / National Institutes of Health 6/07/2010
BRIGHAM YOUNG UNIVERSITY $49,650 Grant Trans-NIH Recovery Act Research Support: Degeneration of synovial joint cartilage in the form of osteoarthritis (OA) is one of the leading causes of chronic disability, yet the molecular pathogenesis of OA is poorly understood. Therefore, the development and study of appropriate animal models is Health and Human Services, Department of / National Institutes of Health 5/26/2010
UNIVERSITY OF CALIFORNIA, DAVIS $230,688 Grant Trans-NIH Recovery Act Research Support: ARRA Supplement: HIV-Specific T-Cell Responses in Rectal Mucosa. The overall goal of this project is to enhance our understanding of host-virus interactions during chronic infection, with a focus on the immune mechanisms governing control of virus replica Health and Human Services, Department of / National Institutes of Health 6/07/2010
ILSBIO LLC $170,016 Contract : ILS Bio has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of various cancer tissues (135 cases). These cases are all primary and untreated. The col Health and Human Services, Department of / National Institutes of Health 4/16/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $1,414,616 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The Albert Einstein College of Medicine (AECOM), a world leader in research of diseases of national and global importance, is poised to vastly enhance its translational program. We request a Siemens Inveon MicroPET/SPE Health and Human Services, Department of / National Institutes of Health 6/10/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $1,265,432 Grant Trans-NIH Recovery Act Research Support: Foundations will be laid in this proposal for use of both functional magnetic resonance imaging (fMRI) maps and resting state functional connectivity maps to study brain plasticity that occurs following surgery to repair peripheral nerves injured by traum Health and Human Services, Department of / National Institutes of Health 5/08/2009
MAYO CLINIC $861,615 Grant Trans-NIH Recovery Act Research Support: The RELIVE (Renal and Lung Living Donors Evaluation) Study is a National Institute of Allergy and Infectious Diseases (NIAID) funded, multi-site effort to determine the long-term risks of live donor nephrectomy 5-50 years later for donors at Mayo Clinic a Health and Human Services, Department of / National Institutes of Health 6/28/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $347,000 Grant Trans-NIH Recovery Act Research Support: The W.M. Keck Center for Cellular Imaging (KCCI), an internationally recognized center for advanced light microscopy imaging that is particularly known for protein-protein interaction imaging, is requesting a Frequency-domain Fluorescence Lifetime Imaging Health and Human Services, Department of / National Institutes of Health 5/13/2010
GOVCONNECTION, INC. $518,977 Contract : The contractor shall provide Biowulf Cluster Core Network Switch Replacement Health and Human Services, Department of / National Institutes of Health 3/24/2010
KENNESAW STATE UNIVERSITY $388,449 Grant Trans-NIH Recovery Act Research Support: The long-term objectives of this proposal are to understand the neurobiological basis of complex cognitive, perceptual and motor processes from the standpoint of neurophysiological and neuroanatomical specializations of the left and right cerebral hemisph Health and Human Services, Department of / National Institutes of Health 5/01/2010
DANA-FARBER CANCER INSTITUTE, INC. $390,000 Grant Trans-NIH Recovery Act Research Support: The Illumina Genome Analyzer IIx (GA II) is a robust, versatile Next Generation DNA sequencing instrument with a wide range of validated applications, including whole genome DNA sequencing, transcriptome resequencing, whole-genome methylation profiling, d Health and Human Services, Department of / National Institutes of Health 4/15/2010
APPLIED BIOSYSTEMS, LLC $6,020 Contract : This is part of an award total of $164,213.75 from MAY 29, 2009 (instrument purchase of 7900HT and supplies). The contract mod was received in June. Therefore, the original amount should be only $158,193.75. Subaward information supplied during previou Health and Human Services, Department of / National Institutes of Health 6/15/2009
THE CHILDREN'S HOSPITAL OF PHILADELPHIA $100,000 Grant Trans-NIH Recovery Act Research Support: The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a multifunctional protein that both transports Cl- across the apical plasma membrane of epithelial cells and regulates ion transport by other proteins, such as the Epithelial Sodium Channe Health and Human Services, Department of / National Institutes of Health 5/28/2010
LEICA MICROSYSTEMS INC. $932,070 Contract : PURCHASE and installation of Leica TCS STED CW CONFOCAL MICROSCOPE in Cerebral Metabolism Lab Health and Human Services, Department of / National Institutes of Health 5/18/2010
MOLECULAR SENSING, INC. $199,994 Grant Trans-NIH Recovery Act Research Support: SBIR Catalyst Award to develop a High Throughput (HT), Label-Free Molecular Interaction Platform for Membrane Protein Targets. Drugs directed aganst cell membrane targets comprise one of the most important classes of therapeutics and focused pharmaceutica Health and Human Services, Department of / National Institutes of Health 4/23/2010
UNIVERSITY OF TEXAS M D ANDERSON $258,180 Contract : The MD Anderson Cancer Center has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of endometrial cases. These cases are all primary and untreated. Th Health and Human Services, Department of / National Institutes of Health 4/27/2010
CHILDREN'S HOSPITAL CORPORATION, THE $97,350 Grant Trans-NIH Recovery Act Research Support: Transcripts for two tetrahydrobiopterin (BH4) synthetic enzymes, GTP cyclohydrolase 1 (GCH1) and sepiapterin reductase, and a BH4 recycling enzyme quinoid dihydroypteridine reductase, are upregulated in dorsal root (DRG) neurons after peripheral nerve inj Health and Human Services, Department of / National Institutes of Health 4/27/2010
RNSOLUTIONS, INC. $726,380 Contract : NIH Grant Implementation Support Services for eRA. Health and Human Services, Department of / National Institutes of Health 5/12/2010
TRUDEAU INSTITUTE, INC. $501,680 Grant Trans-NIH Recovery Act Research Support: A goal of successful protein subunit vaccination against deadly pathogens is to establish a depot of antigens within an inflammatory context to induce protective immunity. However, the impact of antigen depots in the context of acute infection-induced in Health and Human Services, Department of / National Institutes of Health 5/04/2009
UNIVERSITY OF ALABAMA AT BIRMINGHAM $9,083 Grant Trans-NIH Recovery Act Research Support: This grant provided a summer research experience for 1 college student in health-related scientific research. It supplements 5R01HD058573-02, Using Virtual Reality to Train Children in Pedestrian Safety, a Randomized Controlled Trial research project des Health and Human Services, Department of / National Institutes of Health 5/03/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $54,036 Grant Trans-NIH Recovery Act Research Support: Title: Immunosuppression Withdrawal for Stable Pediatric Liver Transplant Recipients - To be utilized to help fund series of investigator meeting to be held during the course of the parent grant. The meetings will be attended by PI, Co-PI and critical per Health and Human Services, Department of / National Institutes of Health 5/05/2010
VWR INTERNATIONAL, LLC $18,848 Contract : Award of EBUY solicitation RFQ449274/RML-RFQ-10007, quote VBQ 3581046. Health and Human Services, Department of / National Institutes of Health 5/15/2010
BOSTON MEDICAL CENTER CORPORATION $53,025 Grant Trans-NIH Recovery Act Research Support: This supplement is intended to enhance the progress of Aim 1 of the K08 research proposal, which is to define the role of specific myosin heavy chain isoforms in the maintenance of actomyosin-based traction force generation in cultured wild-type murine po Health and Human Services, Department of / National Institutes of Health 4/09/2010
TRUSTEES OF INDIANA UNIVERSITY $124,993 Grant Trans-NIH Recovery Act Research Support: A primary purpose of this supplement is to shorten the time needed to reach full recruitment into the parent grant and to learn more about the relative successfulness of different strategies to improve public knowledge about personal risk for pre-diabetes Health and Human Services, Department of / National Institutes of Health 5/11/2010
UNIVERSITY OF WISCONSIN SYSTEM $250,171 Grant Trans-NIH Recovery Act Research Support: Hydroxylamine and nitroso metabolites have been implicated in the pathogenesis of adverse reactions to sulfamethoxazole (SMX) and other arylamine drugs. Hydroxylamines spontaneously oxidize to reactive nitroso metabolites, which, in the case of SMX, can Health and Human Services, Department of / National Institutes of Health 4/09/2010
THE VANDERBILT UNIVERSITY $623,650 Grant Trans-NIH Recovery Act Research Support: The overarching goal of the proposal is to design and develop neuroscience-oriented educational and outreach materials in collaboration with the Adventure Science Center (ASC) of Nashville, and which bolster the mission of the Vanderbilt Silvio O. Conte C Health and Human Services, Department of / National Institutes of Health 5/21/2010
WAKE FOREST UNIVERSITY $54,659 Grant Trans-NIH Recovery Act Research Support: Phagocytic NADPH oxidase (Phox) is critically important for generating reactive oxygen species with microbicidal activity. Recently, nonphagocytic NADPH oxidase (Nox) isoforms have been identified which generate reactive oxygen species that function in si Health and Human Services, Department of / National Institutes of Health 6/28/2010
GEORGE MASON UNIVERSITY $394,646 Grant Trans-NIH Recovery Act Research Support: Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcription DESCRIPTION:Human immunodeficiency virus (HIV) is the etiological agent of acquired immunodeficiency syndrome (AIDS). AIDS is characterized by CD4+ T lymphocyte depleti Health and Human Services, Department of / National Institutes of Health 6/23/2010
RUSH UNIVERSITY MEDICAL CENTER $998,229 Grant Trans-NIH Recovery Act Research Support: There are marked health disparities in the US Chinese population, yet we have the most rudimentary understanding of many critical health issues. In addition, there are vast linguistic and cultural challenges that confront health sciences research in Chine Health and Human Services, Department of / National Institutes of Health 6/10/2010
KECK GRADUATE INSTITUTE OF APPLIED LIFE SCIENCES $153,336 Contract : Software development to facilitate EXPAR assay design for pathogen detection: This project utilizes the isothermal Exponential Amplification Reaction (EXPAR) to enable rapid, simple, and inexpensive nucleic acid testing for identification of Herpes Simple Health and Human Services, Department of / National Institutes of Health 6/01/2010
UNIVERSITY OF TEXAS AT AUSTIN $480,070 Grant Trans-NIH Recovery Act Research Support: The goal of this application is to provide the investigators from the University of Texas at Austin with a small animal imaging system that will provide the necessary means and resources to further their multi- disciplinary research. The instrument, a hig Health and Human Services, Department of / National Institutes of Health 6/10/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $346,500 Grant Trans-NIH Recovery Act Research Support: Francisella tularensis tularensis is a category A select agent for Biodefense Research. It is a highly efficient zoonotic pathogen that has an infectious dose of 10 organisms or less. To accomplish this feat the bacterium has clearly devised efficient m Health and Human Services, Department of / National Institutes of Health 6/14/2010
VISIONGATE, INC. $2,621,703 Grant Trans-NIH Recovery Act Research Support: VisionGate has developed the Cell-CT platform for initial use in the three following markets: 1) Detection and management of gastroesophageal reflux disease (GERD), 2) Lung cancer risk assessment (detection of other cancers, in the pipeline), 3) Academic Health and Human Services, Department of / National Institutes of Health 6/18/2010
KANSAS STATE UNIVERSITY $444,000 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Metalloprotease disintegrin ADAM12 is emerging as an important breast cancer-related gene and a potential target for breast cancer therapies. Two somatic mutations, D301H in the metalloprotease domain and G479E in the Health and Human Services, Department of / National Institutes of Health 6/02/2010
CHILDREN'S HOSPITAL & RESEARCH CENTER $494,550 Grant Trans-NIH Recovery Act Research Support: This award support the purchase of a Zeiss LSM 710 Spectral Confocal Microscope for use at Children's Hospital Oakland Research Institute (CHORI) to facilitate an array of projects that involve microscopy of live and fixed cells. Nine major users and a to Health and Human Services, Department of / National Institutes of Health 4/22/2010
UNIVERSITY OF FLORIDA $101,438 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to understand the molecular mechanisms governing post-initiation events in postreplicative gene transcription during vaccinia virus infection. In recent years it has become increasingly clear that post-initiation events in tran Health and Human Services, Department of / National Institutes of Health 4/12/2010
LOYOLA UNIVERSITY OF CHICAGO $212,250 Grant Trans-NIH Recovery Act Research Support: 'Eph/Ephrin signaling in Taste Nerve Targeting. The first aim of the proposed work is to determine which Ephs and ephrins are expressed in gustatory epithelia in the tongue and palate and the sensory nerves that innervate them during embryonic development Health and Human Services, Department of / National Institutes of Health 6/09/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $642,250 Grant Trans-NIH Recovery Act Research Support: The overall purpose of the of the funded project is to develop a more complete understanding of the interaction of antimicrobial peptides (AMPs) with bacterial and eukaryotic cell membranes. To achieve this goal, we will determine the effects of membrane Health and Human Services, Department of / National Institutes of Health 9/16/2009
BETH ISRAEL DEACONESS MEDICAL CENTER INC $164,524 Grant Trans-NIH Recovery Act Research Support: Previous studies suggest that sepsis-induced muscle wasting is associated with increased muscle calcium levels and that glucocorticoids are the predominant mediator of sepsis-induced muscle proteolysis. The overall hypothesis of the current project is tha Health and Human Services, Department of / National Institutes of Health 12/21/2009
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $895,209 Grant Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (11) Regenerative Medicine and specific Challenge Topic, 11-HL-101* Develop cell-based therapies for cardiovascular, lung, and blood diseases. Given their self-renewing and pluripotent nature, human embryoni Health and Human Services, Department of / National Institutes of Health 4/21/2010
MASSACHUSETTS INSTITUTE OF TECHNOLOGY $282,087 Grant Trans-NIH Recovery Act Research Support: The goal of the approved grant is the microbial production of the potent anticancer drug taxol (paclitaxel) and potentially other natural products of the isoprenoid pathway with pharmaceutical properties. This is to be achieved by: (a) identifying the mis Health and Human Services, Department of / National Institutes of Health 6/11/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $43,563 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Chronic gastroesophageal acid reflux and its sequela, Barrett's esophagus (BE), are strong risk factors for esophageal adenocarcinoma, a tumor whose frequency has increased six-fold over the past 30 years. The molecula Health and Human Services, Department of / National Institutes of Health 6/22/2010
MONTANA STATE UNIVERSITY, INC $1,069,166 Grant Trans-NIH Recovery Act Research Support: The purpose of this project is to develop a treatment, utilizing protein cage nanoparticles, that protects against a broad spectrum of lung viruses and bacteria by augmenting both innate and adaptive immune responses, resulting in less disease through not Health and Human Services, Department of / National Institutes of Health 6/28/2010
OREGON HEALTH & SCIENCE UNIVERSITY $148,621 Grant Trans-NIH Recovery Act Research Support: Longitudinal Assessment of Bariatric Surgery (LABS) consortium was established in 2003 and was conceived to address important issues in bariatric surgery and metabolism in the obese and morbidly obese. LABS explores relationships of patient characteristi Health and Human Services, Department of / National Institutes of Health 4/01/2010
WASHINGTON METROPOLITAN AREA TRANSIT AUTHORITY $267,057 Contract : These ARRA funds provided SmartBenefits on SmarTrip cards to NIH employees that they may use to ride MetroBus or MetroRail. The fare media may also be used on DASH, Ride On, Fairfax Connector, ART, CUE, Loudoun County Transit, Omniride, TheBus, DC Circula Health and Human Services, Department of / National Institutes of Health 4/30/2010
SAINT FRANCIS UNIVERSITY $12,680 Grant Trans-NIH Recovery Act Research Support: Conotoxins are small, disulfide-rich peptides having the ability to differentiate between various types of ion channels, making them ideal diagnostic tools in the characterization of neuronal pathways and in drug development. One member of this family, co Health and Human Services, Department of / National Institutes of Health 3/05/2010
THE INSTITUTE FOR CANCER RESEARCH $21,331 Grant Trans-NIH Recovery Act Research Support: Title: Orthropoxvirus Pathogenesis and Vaccines Abstract: Funds are requested to support the work of two undergraduate students during the summer. One of the students will help in experiments to determine the role of cytotoxic T cells in resistance to e Health and Human Services, Department of / National Institutes of Health 5/24/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $84,393 Grant Trans-NIH Recovery Act Research Support: Molecular genetics of pancreas development This administrative supplement is aimed to conduct a chemical screen for small molecules that enhance pancreatic beta-cell neogenesis. PUBLIC HEALTH RELEVANCE: Type 1 diabetes results from the targeted destruct Health and Human Services, Department of / National Institutes of Health 4/05/2010
THE JACKSON LABORATORY $544,238 Grant Trans-NIH Recovery Act Research Support: The goal of this project is the continued development and maintenance of the Gene Expression Database (GXD). GXD is a community resource that focuses on gene expression data from the laboratory mouse, with a particular emphasis on mouse development. GXD i Health and Human Services, Department of / National Institutes of Health 4/19/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $76,679 Grant Trans-NIH Recovery Act Research Support: The overall goal of this project is to determine the role of oxidative stress with associated inflammation and abnormalities in nitric oxide synthase (NOS) in the pathogenesis of clinical cardiovascular disease (CVD), carotid IMT, cardiac MRI and microvas Health and Human Services, Department of / National Institutes of Health 5/03/2010
SELECTA BIOSCIENCES, INC. $2,996,608 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to develop a superior anti-nicotine vaccine for smoking cessation. A high incidence of smoking makes smoking-related diseases the leading cause of preventable death and morbidity. Even though 70% of smokers desire to quit and 4 Health and Human Services, Department of / National Institutes of Health 4/30/2010
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE $12,165 Grant Trans-NIH Recovery Act Research Support: The overall goals of the project are: 1) to further elucidate how S-nitrosylation and subsequent oxidation can mimic genetic mutations involved in familial PD to cause protein misfolding, abnormal signaling, and eventually neuronal cell injury and death; Health and Human Services, Department of / National Institutes of Health 5/28/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $1,128,568 Grant Trans-NIH Recovery Act Research Support: We plan a multi-center study to accurately describe the natural history of late kidney transplant failure, and to dissect out individual entities leading to late deterioration of function and to graft loss. Previous studies, and the current literature, at Health and Human Services, Department of / National Institutes of Health 6/28/2010
TRUSTEES OF INDIANA UNIVERSITY $385,000 Grant Trans-NIH Recovery Act Research Support: This R01 study is being conducted by the principal investigator to investigate lithium effects after 2 and 8 weeks on the brainG??s mood-regulating corticolimbic circuitry using functional magnetic resonance imaging (fMRI). Besides behavioral response, th Health and Human Services, Department of / National Institutes of Health 5/12/2010
JESKELL INCORPORATED $1,499,889 Contract : Jeskell, the prime contractor, provided an IBM iDataPlex High Performance Computing System, consisting of 336 computing nodes, and installed it at NIH's Center for Information Technology. The computer is being used in CIT's Biowulf computing complex for h Health and Human Services, Department of / National Institutes of Health 4/13/2010
WASHINGTON UNIVERSITY, THE $556,148 Grant Trans-NIH Recovery Act Research Support: This is a competitive revision in response to NOT-OD-09-058, the ARRA call for Competitive Supplement Applications. In the past decade there has been a growing awareness of the disabling effects of impaired cognition in individuals with schizophrenia and Health and Human Services, Department of / National Institutes of Health 6/29/2010
TRUSTEES OF TUFTS COLLEGE INC $616,048 Grant Trans-NIH Recovery Act Research Support: The large conductance Ca2+-activated K+ channel, or BKCa channel, is found in a wide variety of cell types where in general it provides feedback control over processes like neurotransmission and smooth muscle contraction that involve membrane-potential de Health and Human Services, Department of / National Institutes of Health 6/30/2010
KENTUCKY PHARMACEUTICALS, INC. $199,998 Grant Trans-NIH Recovery Act Research Support: The overall goal of this project is to develop the lateral flow assay for detecting complement levels and complement activation status in a patient. This assay will give results in seconds versus either hours or days that normal complement lab assays have Health and Human Services, Department of / National Institutes of Health 4/08/2010
UNIVERSITY OF UTAH, THE $170,646 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Previous research led to the discovery that HIV-1 utilizes TSG101/ESCRT-I and the cellular pathway of MVB vesicle formation to bud from cells. Our studies also provided a general overview of the individual components o Health and Human Services, Department of / National Institutes of Health 6/01/2010
WABASH COLLEGE $263,986 Grant Trans-NIH Recovery Act Research Support: In addiction, drug taking and behaviors associated with drug taking become rigid and difficult to modify. While the pharmacological actions of drugs that support addiction are well characterized, how these drugs interact with learning systems in the brain Health and Human Services, Department of / National Institutes of Health 5/24/2010
WASHINGTON METROPOLITAN AREA TRANSIT AUTHORITY $47,680 Contract : These ARRA funds provided SmartBenefits on SmarTrip cards to NIH employees that they may use to ride MetroBus or MetroRail. The fare media may also be used on DASH, Ride On, Fairfax Connector, ART, CUE, Loudoun County Transit, Omniride, TheBus, DC Circula Health and Human Services, Department of / National Institutes of Health 3/23/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $464,882 Grant Trans-NIH Recovery Act Research Support: This award will be used to purchase a multi-use fluorescence microscope to be shared by three NIH R01 supported Principal Investigators and one NIH K99 supported investigator in the Department of Biochemistry at Stanford University School of Medicine. The Health and Human Services, Department of / National Institutes of Health 6/10/2010
UNIVERSITY OF ARKANSAS SYSTEM $93,358 Grant Trans-NIH Recovery Act Research Support: We are requesting funds to purchase a new gas chromatograph mass spectrometer. This project involves tracing a variety of metabolic pathways using stable isotope tracers. The study will be performed in pigs with multiple catheters, placed so that regional Health and Human Services, Department of / National Institutes of Health 6/17/2010
CARNEGIE MELLON UNIVERSITY $432,760 Grant Trans-NIH Recovery Act Research Support: This awards supports the purchase of an Andor Revolution XD Spinning Disk Confocal System on a Nikon Perfect Focus TIRF Microscope. The acquisition of this instrument will provide on-site access to state of the art high-speed multi-color confocal and TIR Health and Human Services, Department of / National Institutes of Health 4/29/2010
INNOVATIVE BIOTHERAPIES, INC. $142,000 Grant Trans-NIH Recovery Act Research Support: The focus of this supplemental funding is to acquire more knowledge about the fluid dynamics of nutrient delivery and surface forces in the BRECS system. The challenge of this project is the complexity of the porous scaffold and the difficulty it will pro Health and Human Services, Department of / National Institutes of Health 4/01/2010
UNIVERSITY OF WASHINGTON $120,591 Grant Trans-NIH Recovery Act Research Support: We are proposing additional research through an ARRA administrative supplement in order to conduct studies that leverage existing samples and data to accelerate the pace of research in the field of HIV prevention. Briefly, the parent study entitled, Anti Health and Human Services, Department of / National Institutes of Health 6/01/2010
UNIVERSITY OF IOWA, THE $235,649 Grant Trans-NIH Recovery Act Research Support: HIV disease progression varies widely among individuals. Although some genetic or HIV protein factors have been identified that affect disease progression, these do not explain slow HIV disease progression in most cases. We and others found an association Health and Human Services, Department of / National Institutes of Health 4/19/2010
MAYO CLINIC $393,775 Grant Trans-NIH Recovery Act Research Support: The ultimate goal of virtually all immunological research is to generate medicines that would allow precise therapeutic control of the human immune system. Drugs that would control T cell function are sought with the aim of preventing organ transplant rej Health and Human Services, Department of / National Institutes of Health 6/14/2010
UNIVERSITY OF WISCONSIN SYSTEM $1,000,000 Grant Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (03) Biomarkers Discovery and Validation and specific Challenge Topic, 03-HL-101: Identify and validate clinically relevant, quantifiable biomarkers of diagnostic and therapeutic responses for blood, vascula Health and Human Services, Department of / National Institutes of Health 4/12/2010
OKLAHOMA MEDICAL RESEARCH FOUNDATION $97,258 Grant Trans-NIH Recovery Act Research Support: The critical assays designed to address each of the three funded aims are heavily dependent on live cell microscopy, using methods that we developed specifically for this purpose. The ARRA funds requested will be used for a microscope upgrade that will p Health and Human Services, Department of / National Institutes of Health 4/28/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $578,200 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Radiation-induced gastrointestinal syndrome (RIGS) results from a combination of direct cytocidal effects on intestinal crypt and endothelial cells and subsequent loss of the mucosal barrier, resulting in microbial inf Health and Human Services, Department of / National Institutes of Health 4/05/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $15,396 Grant Trans-NIH Recovery Act Research Support: Aims of the parent R01 project hinge on highthroughput molecular cloning and immunological analyses. The current supplement request is focused on accelerating goals outlined specifically in these aims. Currently, we utilize different mutagenesis strategie Health and Human Services, Department of / National Institutes of Health 5/17/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $81,500 Grant Trans-NIH Recovery Act Research Support: Adjuvant chemotherapy and tamoxifen have been shown to reduce the risk of contralateral breast cancer (CBC) among women with a previous history of breast cancer. It is well recognized that not all individuals metabolize drugs with the same efficiency or e Health and Human Services, Department of / National Institutes of Health 6/01/2009
OREGON HEALTH & SCIENCE UNIVERSITY $385,000 Grant Trans-NIH Recovery Act Research Support: Ricin is a potent toxin whose wide availability and ease of purification has resulted in its development as an agent of bioterrorism. The most likely and lethal means of delivery of ricin by terrorists to human populations would be by aerosolization. Th Health and Human Services, Department of / National Institutes of Health 6/21/2010
MICHIGAN STATE UNIVERSITY $102,348 Grant Trans-NIH Recovery Act Research Support: This supplemental funding will accelerate research on the structures and membrane locations of HIV and influenza virus fusion peptides and proteins. These structural data will aid development of new antiviral therapeutics whose mode of action is inhibitio Health and Human Services, Department of / National Institutes of Health 6/01/2010
UNIVERSITY OF MASSACHUSETTS $67,996 Grant Trans-NIH Recovery Act Research Support: Immunology of Infection with Neisseria gonorrhoeae. Gonorrhea is the second most commonly reported bacterial sexually transmitted infection in the US. With 332,511 new cases having been reported in 2007. More than 60 million cases are estimated to occur Health and Human Services, Department of / National Institutes of Health 4/05/2010
TRUSTEES OF BOSTON UNIVERSITY $80,953 Grant Trans-NIH Recovery Act Research Support: The Supplement is designed to to expand our work under this project to include: 1) evaluation of the impact of additional (i.e., lower) doses of BPA in our mouse uterus studies with the goal of establishing a no observable adverse effect level (NOAEL) for Health and Human Services, Department of / National Institutes of Health 6/10/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $183,150 Grant Trans-NIH Recovery Act Research Support: Hepatitis virus infection remains a major health issue throughout the world. Although there are effective drugs and a vaccine for hepatitis B (HBV) infection, there are almost 200,000,000 people infected worldwide. It is estimated that 2 to 4% of American Health and Human Services, Department of / National Institutes of Health 4/12/2010
SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH $2,068,328 Grant Trans-NIH Recovery Act Research Support: High performance computation lies at the heart of modern human statistical genomics. In the Department of Genetics at the Southwest Foundation for Biomedical Research (SFBR), we specialize in the genetic dissection of human complex diseases that typically Health and Human Services, Department of / National Institutes of Health 5/06/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $88,534 Grant Trans-NIH Recovery Act Research Support: The research will result in a better understanding of the mechanisms by which general anesthetics act on ligand-gated ion channels. This provides the scientific foundation upon which anesthetics with higher affinity and lower toxicity may be developed. Health and Human Services, Department of / National Institutes of Health 6/04/2010
OKLAHOMA MEDICAL RESEARCH FOUNDATION $311,251 Grant Trans-NIH Recovery Act Research Support: The objective of this proposal is to establish a start-of-the-art high-throughput serum analysis system (HTSAS) for the detection and quantification of serum analytes in humans and research animals. The envisioned system is centered on multiplex detection Health and Human Services, Department of / National Institutes of Health 4/01/2010
EAST TENNESSEE STATE UNIVERSITY $422,373 Grant Trans-NIH Recovery Act Research Support: Trauma-hemorrhage is the most common cause of morbidity and mortality in immediate survivors of accidents, terrorist attacks, natural disasters, warfare casualties and medical emergencies. Injury accounts for 40% to 80% of total death for people between o Health and Human Services, Department of / National Institutes of Health 5/24/2010
NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC. $222,300 Grant Trans-NIH Recovery Act Research Support: Osteoporosis is a serious disorder of ageing men and women, and is prevalent in the veteran population. The present studies are designed to define the mechanisms that control normal bone formation and that are necessary and sufficient for anabolic respon Health and Human Services, Department of / National Institutes of Health 4/05/2010
TRUSTEES OF THE SMITH COLLEGE, THE $392,437 Grant Trans-NIH Recovery Act Research Support: In the course of its existence, a bacterium may transit through many different locations, both in the external environment and within an animal host. Bacteria have the ability to sense a multitude of environmental stimuli and use these cues to regulate ge Health and Human Services, Department of / National Institutes of Health 4/02/2010
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE $719,340 Grant Trans-NIH Recovery Act Research Support: Immune tolerance in the therapy of rheumatoid arthritis: These studies seek to unravel the immunological mechanisms which lead to the observed immune deviation and which ultimately determine response to the tolerization treatment with dnaJP1. The hypot Health and Human Services, Department of / National Institutes of Health 6/07/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $85,680 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): HIV-1 particle production, a process driven by the viral structural protein Gag, takes place predominantly at the plasma membrane in cell types including T cells, whereas in macrophages a majority of virus particles ap Health and Human Services, Department of / National Institutes of Health 5/17/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $37,571 Grant Trans-NIH Recovery Act Research Support: The 300kDa cation-independent mannose 6-phosphate receptor (CI-MPR) and the 46kDa cation-dependent MPR (CD-MPR) interact with various proteins by virtue of their ability to bind mannose 6-phosphate (Man-6-P) residues found on N-linked oligosaccharides of Health and Human Services, Department of / National Institutes of Health 12/28/2009
MEDICAL COLLEGE OF WISCONSIN, INC., THE $234,644 Grant Trans-NIH Recovery Act Research Support: This proposal will fund a position for one Research Technologist III for two years. This individual will begin extracting DNA and genotyping samples in year 1 of the parent grant entitled, Genetic Variation and Biomarkers in Children with Acute Lung Injur Health and Human Services, Department of / National Institutes of Health 7/16/2009
FLORIDA A & M UNIVERSITY $52,956 Grant Trans-NIH Recovery Act Research Support: The supplemental funding will provide Hillsborough Community College to Florida A&M University (HCC-FAMU) Bridges to the Baccalaureate students with increased opportunities to enhance their knowledge base and develop their research skills in order to incr Health and Human Services, Department of / National Institutes of Health 4/09/2010
UNIVERSITY OF NEW MEXICO $8,387 Grant Trans-NIH Recovery Act Research Support: Chagas disease afflicts over 12 million people in Central and South America. Eradication efforts directed at the triatomine vectors of this disease have been effective, but are fraught with issues of cost, toxicity of pesticides and vector resistance. A p Health and Human Services, Department of / National Institutes of Health 5/24/2010
TRANSPOSAGEN BIOPHARMACEUTICALS, INC. $174,707 Grant Trans-NIH Recovery Act Research Support: NOVEL SCID RAT MODELS FOR HUMAN CELL TRANSPLANTATION STUDIES Health and Human Services, Department of / National Institutes of Health 7/01/2010
JEOL USA, INC. $412,800 Contract : tO DELIVER, INSTALL AND PROVIDE TRAINING FOR THE JEOL USA JEM-1400 TRANSMISSION ELECTRON MICORSCOPE AND ACCESSORIES Health and Human Services, Department of / National Institutes of Health 4/06/2010
UNIVERSITY OF WISCONSIN SYSTEM $33,417 Grant Trans-NIH Recovery Act Research Support: This proposal requests an administrative supplement to support sharing autism spectrum disorder (ASD)data via the National Database for Autism Research (NDAR). The parent grant, Early Language Abilities in Toddlers on the Autism Spectrum (R01 DC007223), e Health and Human Services, Department of / National Institutes of Health 5/10/2010
JOHNS HOPKINS UNIVERSITY, THE $208,227 Grant Trans-NIH Recovery Act Research Support: The award will allow the purchase of equipment for continuation of AIMs 1-4 of the original R01AI063764 and hiring of personnel to support the research. We expect to learn of mechanisms that control MHC class II antigen processing and the contribution of Health and Human Services, Department of / National Institutes of Health 6/28/2010
UNIVERSITY OF WASHINGTON $267,195 Grant Trans-NIH Recovery Act Research Support: This Program Project proposes to facilitate an improved understanding of biological systems governing food intake, body fat mass and obesity pathogenesis. While many key molecules and neuronal cell types have been identified, it is the interactions betwee Health and Human Services, Department of / National Institutes of Health 5/25/2010
OREGON HEALTH & SCIENCE UNIVERSITY $222,650 Grant Trans-NIH Recovery Act Research Support: A group of investigators at the Oregon National Primate Research Center (ONPRC) request funds to purchase a Laser Capture Microdissection System. The instrument will be used to procure pure populations of cells out of complex tissues, necessary to isolate Health and Human Services, Department of / National Institutes of Health 5/20/2010
DUKE UNIVERSITY $259,351 Grant Trans-NIH Recovery Act Research Support: The American College of Surgeons Oncology Group (ACOSOG) is dedicated to improving the care of the surgical oncology patient through an innovative clinical research program addressing three specific aims: 1. To test novel therapies that may increase respo Health and Human Services, Department of / National Institutes of Health 6/18/2010
UNIVERSITY OF WISCONSIN SYSTEM $364,218 Grant Trans-NIH Recovery Act Research Support: Calcium has been one of the most versatile biological messengers in a cell, playing critical roles in regulating the cell's functions. In particular, the transient change of calcium concentration in cardiac muscle cells (myocytes) forms the basis of cell- Health and Human Services, Department of / National Institutes of Health 4/21/2010
WHITEHEAD INSTITUTE FOR BIO-MEDICAL RESEARCH $499,968 Grant Trans-NIH Recovery Act Research Support: Funds were requested to purchase a complete Genome Analyzer-IIx sequencer package including cluster station and paired-end read module from Illumina technologies. The system will provide critically needed capacity for an overburdened sequencing pipeline t Health and Human Services, Department of / National Institutes of Health 4/08/2010
REGENERX BIOPHARMACEUTICALS, INC. $3,000,000 Grant Trans-NIH Recovery Act Research Support: RegeneRx Biopharmaceuticals Inc. has the long-term goal of developing Thymosin Beta 4 (TB4), a naturally occurring peptide, for use in the treatment of ST-elevation myocardial infarction (STEMI). There are no pharmacological agents on the market to preven Health and Human Services, Department of / National Institutes of Health 5/13/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $500,000 Grant Trans-NIH Recovery Act Research Support: The aims of this Translational Conte Center are (1) to enhance the basic molecular and neurobiological characterization of the role of the alpha7 nicotinic acetylcholine receptor in the brain and its dysfunction in schizophrenia; (2) to use this biology t Health and Human Services, Department of / National Institutes of Health 5/19/2010
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE $2,566,410 Grant Trans-NIH Recovery Act Research Support: The purchase of high-performance computing and storage infrastructure is proposed to advance biomedical research leading to an improved understanding of disease and advances in healthcare. This computational resource will initially be dedicated to the fo Health and Human Services, Department of / National Institutes of Health 6/24/2010
THE VANDERBILT UNIVERSITY $642,794 Grant Trans-NIH Recovery Act Research Support: The parent grant titled Epidemiologic Architecture for Genes Linked to Environment (EAGLE) is funded to use DNA samples from the National Health and Nutrition Examination Surveys for characterizing genetic variations identified through genome-wide associa Health and Human Services, Department of / National Institutes of Health 5/20/2010
THE VANDERBILT UNIVERSITY $131,244 Grant Trans-NIH Recovery Act Research Support: This request for an Administrative Supplement to the grant (5 R01 GM064779-08) entitled 'Proteornic Analysis of Eukaryotic Protein Synthesis' is responsive to NOT-OD-056 (NIH Announces the Availability of Recovery Acts Funds for Administrative Supplemen Health and Human Services, Department of / National Institutes of Health 6/11/2010
CAPRICOR, INC. $2,993,268 Grant Trans-NIH Recovery Act Research Support: Capricor, Inc. is actively developing cardiac stem cell technologies for the treatment of heart disease. Capricor has exclusive license to a method to cultivate cardiac stem cells, present in small numbers in the adult human heart, in order to generate la Health and Human Services, Department of / National Institutes of Health 5/13/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $622,934 Grant Trans-NIH Recovery Act Research Support: The present application proposes the acquisition of high-throughput DNA instrumentation that will enable the rapid generation of genome-level information on a wide spectrum of projects covering developmental biology, molecular evolution of sensory systems Health and Human Services, Department of / National Institutes of Health 4/15/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $339,002 Grant Trans-NIH Recovery Act Research Support: This revised supplement is responsive to the notice NOT-OD-09-058 entitled: 'Enabling RPGs to Leverage NCRR Center and Center-like Programs'. The aims of this revision are designed to utilize the existing framework of our ongoing R01 entitled: 'S. aureus Health and Human Services, Department of / National Institutes of Health 6/01/2010
NATIONAL BUREAU OF ECONOMIC RESEARCH, INC. $2,189,997 Grant Trans-NIH Recovery Act Research Support: The NBER Program Project on the Economics of Aging is a coordinated set of research projects on the health and economic circumstances of individuals as they age and on the implications of population aging. Its six major themes are: work and retirement be Health and Human Services, Department of / National Institutes of Health 4/20/2010
WELLS JR, WILLIAM G $19,500 Contract : Provide senior level management support for review and award of ARRA funded research grants. Health and Human Services, Department of / National Institutes of Health 3/22/2010
TRUSTEES OF INDIANA UNIVERSITY $247,498 Grant Trans-NIH Recovery Act Research Support: Interoperable health information technology (HIT) is widely recognized for its potential improve the quality and efficiency of care. Likewise, HIT can be a key enabler for accelerating the pace and achievement of clinical research. Lack of a common, stand Health and Human Services, Department of / National Institutes of Health 4/22/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $140,941 Grant Trans-NIH Recovery Act Research Support: The goal of this proposal is to expand and accelerate our effort to understand the role of the Sen1 in termination of RNA Polymerase II and to establish how mutations in the human homolog of Sen1, Senataxin cause the neurodegenerative disorders Ataxia?Oc Health and Human Services, Department of / National Institutes of Health 5/28/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $638,318 Grant Trans-NIH Recovery Act Research Support: The purpose of this grant is to purchase a Olympus FV1000MPE multiphoton microscope to be used as the main instrument in a core facility at the Weill Cornell Medical College. The core facility serves translational and basic medical science investigators. Health and Human Services, Department of / National Institutes of Health 4/15/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $197,490 Grant Trans-NIH Recovery Act Research Support: Mechanisms of protective immunity induced by live attenuated simian immunodeficiency virus vaccines. The role of antibody-dependent cell-mediated cytotoxicity in simian immunodeficiency virus infection is poorly understood and infrequently investigated du Health and Human Services, Department of / National Institutes of Health 5/03/2010
OREGON HEALTH & SCIENCE UNIVERSITY $150,000 Grant Trans-NIH Recovery Act Research Support: Animal models have provided insight into the physiology of weight regulation, including the hormonal and neurological communication between adipose tissue, the gut, and the brain. Adipocyte hormones, such as leptin, and gut hormones, such as ghrelin, con Health and Human Services, Department of / National Institutes of Health 5/20/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $366,672 Grant Trans-NIH Recovery Act Research Support: This research will study a newly identified, unique and very abundant cell population: splenic monocytes. We have shown that they exist, play important roles in healing of peripheral organs and in diseases, and consist of different subsets. Using novel in Health and Human Services, Department of / National Institutes of Health 6/21/2010
MEHARRY MEDICAL COLLEGE $418,720 Grant Trans-NIH Recovery Act Research Support: This grant will provide Meharry Medical College investigators and their trainees a confocal microscope system capable of high speed as well as long-term imaging to capture dynamic processes occurring within living cells. The research studies proposed at M Health and Human Services, Department of / National Institutes of Health 6/03/2010
PRESIDENT & TRUSTEES OF WILLIAMS COLLEGE $338,450 Grant Trans-NIH Recovery Act Research Support: Academic Research Enhancement Award: This award supports a biomedical research project that provides opportunities for undergraduate students to engage in meritorious research. Specifically, the broad objective of this project is to elucidate some of th Health and Human Services, Department of / National Institutes of Health 4/05/2010
UNIVERSITY OF ILLINOIS $234,939 Grant Trans-NIH Recovery Act Research Support: Obesity and its associated metabolic and vascular sequalae are important health problems in the United States. The studies proposed in this grant are aimed at increasing the understanding of the physiology and pathophysiology of the adipocyte by investig Health and Human Services, Department of / National Institutes of Health 6/25/2010
BARNARD COLLEGE (INC) $426,690 Grant Trans-NIH Recovery Act Research Support: The specific aim of this project is to determine what cognitive capacities infants and children possess when reasoning about arithmetic, with the broader long-term objective of pinpointing inventive ways to tap into intuitive mathematical skills. There is Health and Human Services, Department of / National Institutes of Health 4/26/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $277,195 Grant Trans-NIH Recovery Act Research Support: Infectious diseases represent a major burden on healthcare resources. In addition, the emergence of antibiotic resistant bacterial strains and concerns of bioterrorism have increased the need to understand the normal defense mechanisms that combat pathoge Health and Human Services, Department of / National Institutes of Health 7/06/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $77,250 Grant Trans-NIH Recovery Act Research Support: Title: Advancing Islet Transplant for Type 1 Diabetes Care - Islet transplantation in T1D patients with kidney transplants has the potential benefit of treating glycemic instability, allowing maintenance of normoglycemia without the need for insulin thera Health and Human Services, Department of / National Institutes of Health 6/21/2010
IMMUNOMEDICS, INC. $192,688 Grant Trans-NIH Recovery Act Research Support: This project will develop two new agents that target the cancer marker, insulin-like growth factor 1 receptor, for the treatment of kidney cancer. Health and Human Services, Department of / National Institutes of Health 6/01/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $848,308 Grant Trans-NIH Recovery Act Research Support: The faithful duplication of the genetic material is fundamental to all biological systems. For viruses as for cells, a complex repertoire of proteins mediates the carefully regulated process of DNA synthesis and coordinates it to the related processes of Health and Human Services, Department of / National Institutes of Health 9/25/2009
UNIVERSITY OF FLORIDA $499,155 Grant Trans-NIH Recovery Act Research Support: Ionizing radiation (IR) released by detonation can cause the most overwhelming disaster. In acute radiation injury (ARI), the major causes of death are the acute gastrointestinal syndrome (AGS) and BMS (bone marrow syndrome). Pathophysiologically, GI and Health and Human Services, Department of / National Institutes of Health 5/10/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $270,303 Grant Trans-NIH Recovery Act Research Support: Functional Analysis of the Proteasome Base - A better understanding of how the proteasome works, the ultimate objective of this grant, will help us to relate proteasome function to human disease and may point to potential new targets for therapeutic appro Health and Human Services, Department of / National Institutes of Health 6/11/2010
UNIVERSITY OF CALIFORNIA, DAVIS $300,000 Grant Trans-NIH Recovery Act Research Support: This supplement to the funding of the Drosophila Population Genomics Project will support new hires of young scientists to conduct research and development in three specific areas of data analysis. Potentially important limitation of available genomic re Health and Human Services, Department of / National Institutes of Health 5/06/2010
PURDUE UNIVERSITY $167,660 Grant Trans-NIH Recovery Act Research Support: The zebrafish possesses characteristics that make it an ideal model for genetic studies of vertebrate development and human disease. Although large-scale forward mutagenesis screens have been successfully applied to the zebrafish to identify genes that r Health and Human Services, Department of / National Institutes of Health 5/21/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $96,000 Grant Trans-NIH Recovery Act Research Support: UNC Center for AIDS Research The purpose of this grant is to obtain a new capillary electrophoresis instrument to increase the work flow of Dr. Weeks in his analysis of the structure of the HIV genome. The increased analytical capacity is expected to in Health and Human Services, Department of / National Institutes of Health 5/17/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $277,271 Grant Trans-NIH Recovery Act Research Support: This is a competitive revision in response to NOT-OD-09-058, the ARRA call for Competitive Supplement Applications. In the past decade there has been a growing awareness of the disabling effects of impaired cognition in individuals with schizophrenia and Health and Human Services, Department of / National Institutes of Health 6/29/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $447,999 Grant Trans-NIH Recovery Act Research Support: Award will support studies of secondhand smoke exposure. The funds are being used to purchase a replacement for an obsolete instrument, and allow our facility to support numerous commitments for biofluid analyses for investigators at our institution. Health and Human Services, Department of / National Institutes of Health 4/22/2010
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE $247,163 Grant Trans-NIH Recovery Act Research Support: Laser-scanning confocal microscopy has become an indispensable tool in biomedicine, driven by the advent of powerful new microscope systems and of wide range of specific fluorescent probes. Currently, state-of-the art confocal microscopy is required for N Health and Human Services, Department of / National Institutes of Health 5/13/2010
BECTON, DICKINSON AND COMPANY $355,515 Contract : chase of: FACSAria II Flow Cytometer Health and Human Services, Department of / National Institutes of Health 5/09/2010
NEW YORK UNIVERSITY (INC) $71,232 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Immobility mediated by volatile anesthetics (VAs) appears to result largely from depression of excitatory neurotransmission at the spinal cord level. Neurons transform electrical and chemical stimuli into meaningful ph Health and Human Services, Department of / National Institutes of Health 6/11/2010
TRUSTEES OF TUFTS COLLEGE INC $205,298 Grant Trans-NIH Recovery Act Research Support: Accumulating molecular data increasingly support an active role for adipose tissue (AT) in the development of obesity and related metabolic diseases. While a number of AT-derived signaling factors have been identified, the mechanisms by which these factor Health and Human Services, Department of / National Institutes of Health 4/23/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $86,538 Grant Trans-NIH Recovery Act Research Support: Cerebrovascular contributions to brain aging and dementia. Cerebrovascular disease (CVD) contributes in a complex manner to a host of detrimental age-related conditions including cognitive decline, neurodegeneration, and the clinical syndrome of Alzheimer Health and Human Services, Department of / National Institutes of Health 5/24/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $250,013 Grant Trans-NIH Recovery Act Research Support: This project is to develop, demonstrate, and validate a pipeline for high-throughput, low-cost targeted resequencing of all human exons based on next-generation (gen2) sequencing techniques in support of the long term goal of enabling sequencing to be use Health and Human Services, Department of / National Institutes of Health 5/28/2010
WAKE FOREST UNIVERSITY $81,551 Grant Trans-NIH Recovery Act Research Support: This proposal is based on two remarkable findings from our lab. First, complement neutralizes the closely related paramyxoviruses Simian Virus 5 (SV5) and Mumps Virus (MuV), but by distinct mechanisms involving formation of massive SV5 aggregates versus c Health and Human Services, Department of / National Institutes of Health 5/10/2010
THERMO FISHER SCIENTIFIC (ASHEVILLE) LLC $5,538 Contract : Laboratory Equipment Order Health and Human Services, Department of / National Institutes of Health 4/23/2010
UNIVERSITY OF WASHINGTON $9,548 Grant Trans-NIH Recovery Act Research Support: This supplement seeks to create a position for an Undergraduate Researcher during the summer. The undergraduate will assist in experiments already covered by the parent grant, as well as allowing for an independent research project to be carried out by th Health and Human Services, Department of / National Institutes of Health 6/07/2010
UNIVERSITY OF NEW MEXICO $375,000 Grant Trans-NIH Recovery Act Research Support: Schistosome parasites cause infectious disease in over 200 million humans globally; some 600 million more are at risk of infection. This disease affects development in children, reduces general health and may ultimately lead to death. The parasites are tr Health and Human Services, Department of / National Institutes of Health 5/04/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $33,857 Grant Trans-NIH Recovery Act Research Support: While health communication plays a critical role in reducing health disparities there are no existing best practice standards for how health information should be disseminated to Chinese Americans. The purpose of this administrative supplement is to explo Health and Human Services, Department of / National Institutes of Health 5/20/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $92,098 Grant Trans-NIH Recovery Act Research Support: Severe osteopenia is a prevalent complication of anorexia nervosa (AN), affecting over half of all women with this disease. Loss of bone mass occurs frequently and is often permanent. Reduction of bone mineral density (BMD) by at least 1.0 SD at one or mo Health and Human Services, Department of / National Institutes of Health 5/07/2010
UNIVERSITY OF WASHINGTON $10,021 Grant Trans-NIH Recovery Act Research Support: This supplement is designed to encourage promising undergraduates to pursue a career in biomedical research with an emphasis on reproductive biology. The contributions of these undergraduates to the work on this project will also accelerate the pace of t Health and Human Services, Department of / National Institutes of Health 4/23/2010
UNIVERSITY OF HOUSTON SYSTEM $450,000 Grant Trans-NIH Recovery Act Research Support: Alcoholism and alcohol abuse is a major cause of death (4.5 percent of the US population) with an economic burden of 184 billion dollars/year in the US. Defining the target(s) and elucidating the molecular mechanism of its action is needed for effective p Health and Human Services, Department of / National Institutes of Health 4/13/2010
MOUNT SINAI SCHOOL OF MEDICINE $184,913 Grant Trans-NIH Recovery Act Research Support: The supplement enables us to substantially increase the bioinformatic resources available to our Conte Center, and eventually to the field at large, by retaining the services of a newly recruited faculty member at Mount Sinai, Dr. Li Shen, who is an exper Health and Human Services, Department of / National Institutes of Health 5/18/2010
OKLAHOMA MEDICAL RESEARCH FOUNDATION $500,000 Grant Trans-NIH Recovery Act Research Support: The funds are requested to purchase a multiphoton laser scanning microscope system. The microscope system consists of: 1) a Zeiss 710 NLO multi-photon imaging system with 3 spectral detection channels, five laser lines for visible light excitation confoca Health and Human Services, Department of / National Institutes of Health 4/22/2010
NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE $2,309,300 Grant Trans-NIH Recovery Act Research Support: We propose the purchase of a Dynamic Nuclear Polarization (DNP) Solid State NMR (SSNMR) spectrometer at 600 MHz. Over the past decade Magic Angle Spinning based Solid State NMR (MAS SSNMR) has made rapid progress, including spectral assignments of many di Health and Human Services, Department of / National Institutes of Health 5/20/2010
STRATEGIC POLYMER SCIENCES, INC. $2,192,113 Grant Trans-NIH Recovery Act Research Support: We aim to develop an advanced electric micro-steerable mapping and ablation catheter using a new class of proprietary EAPs. The micro-steerable catheter can be controlled remotely with a computer and eliminate the X-Ray radiation exposure of the physician Health and Human Services, Department of / National Institutes of Health 6/03/2010
VECNA TECHNOLOGIES, INC. $163,109 Grant Trans-NIH Recovery Act Research Support: The purpose of this project is reduce the number of hospital-infected persons per year. We propose new methods to monitor a clinical informatics data stream, with software that can detect when an outbreak of normal or drug resistant microbes is occurring Health and Human Services, Department of / National Institutes of Health 4/27/2010
JOHNS HOPKINS UNIVERSITY, THE $80,519 Grant Trans-NIH Recovery Act Research Support: This award is an administrative supplement for an equipment purchase necessary to achieve the original goals of the P20GM078494 proposal. The equipment being purchased is a Laser Doppler Imaging system. Health and Human Services, Department of / National Institutes of Health 4/23/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $1,000,000 Grant Trans-NIH Recovery Act Research Support: Niemann Pick Type C (NPC1) is a rare but lethal pediatric dementia caused by a mutation in NPC1, a housekeeping protein residing in the late endosomal compartment with a putative role in cholesterol transport. The result is a severe lipidosis characterize Health and Human Services, Department of / National Institutes of Health 4/19/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $45,228 Grant Trans-NIH Recovery Act Research Support: The supplement requests support to train one high school, one graduate student and one science educator during the summer of 2010. Students or educators who have the opportunity to work on aspects of the above noted project will learn molecular biology, b Health and Human Services, Department of / National Institutes of Health 5/06/2010
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK $29,278 Grant Trans-NIH Recovery Act Research Support: Treatment options for GI motility disorders are limited, reflecting the need for new model systems and for identification of new, effective drug targets. The specific objective of this AREA proposal is to establish the zebrafish as a model system to study Health and Human Services, Department of / National Institutes of Health 6/18/2010
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC $196,946 Grant Trans-NIH Recovery Act Research Support: We will continue our study of genes needed for neuronal differentiation and function in the nematode Caenorhabditis elegans. Most of the research will center, as in the past, on the analysis of the development and activity of the six touch receptor neuron Health and Human Services, Department of / National Institutes of Health 6/18/2010
OPTOACOUSTICS LTD $50,000 Contract : MRI Active Noise Control Headset Health and Human Services, Department of / National Institutes of Health 4/08/2009
UNIVERSITY OF CALIFORNIA, LOS ANGELES $431,867 Grant Trans-NIH Recovery Act Research Support: Chronic bacterial lung infections are the major cause of death in cystic fibrosis. In such chronic infections, antibiotic-resistant bacterial biofilms are formed in the lungs of cystic fibrosis patients. Biofilms are poorly understood due in part to the i Health and Human Services, Department of / National Institutes of Health 6/07/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $272,107 Grant Trans-NIH Recovery Act Research Support: Asthma is the most common chronic disease of childhood in the United States. Children living in poverty and in urban centers, many of whom are persons of color and are at greater risk for environmental exposures, suffer disproportionately from asthma. Man Health and Human Services, Department of / National Institutes of Health 7/01/2010
UNIVERSITY OF CALIFORNIA, DAVIS $261,061 Grant Trans-NIH Recovery Act Research Support: This is a competitive revision in response to NOT-OD-09-058, the ARRA call for Competitive Supplement Applications. In the past decade there has been a growing awareness of the disabling effects of impaired cognition in individuals with schizophrenia and Health and Human Services, Department of / National Institutes of Health 6/29/2010
UNIVERSITY OF WASHINGTON $83,230 Grant Trans-NIH Recovery Act Research Support: Sleep disturbances are a significant and costly health care problem in the United States. The specific aims of the University of Washington Center for Research on Management of Sleep Disorders (CRMSD) are as follows: 1. Establish, maintain, and coordina Health and Human Services, Department of / National Institutes of Health 5/20/2010
RESEARCH & DIAGNOSTIC ANTIBODIES $2,585,963 Grant Trans-NIH Recovery Act Research Support: PUBLIC HEALTH RELEVANCE: Annually, more than 7 million people worldwide are affected by the hemodynamic, pulmonary and renal dysfunction associated with systemic inflammatory response syndrome (SIRS) that deteriorates into the sepsis pathology and causes Health and Human Services, Department of / National Institutes of Health 6/11/2010
DUKE UNIVERSITY $392,500 Grant Trans-NIH Recovery Act Research Support: Human autoinflammatory syndromes represent a diverse set of diseases, including hereditary periodic fevers (HPF), Type 2 diabetes and gout, which are characterized by overexpression of IL-1b in the absence of recognized inflammatory stimuli. IL-1b is mad Health and Human Services, Department of / National Institutes of Health 6/14/2010
VWR INTERNATIONAL, LLC $14,821 Contract : Lorenzo McMillan's 2 Mastercycler Pro award based on VBQ 3591589. Health and Human Services, Department of / National Institutes of Health 5/27/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON $994,635 Grant Trans-NIH Recovery Act Research Support: Cellular transplantation of lung stem/progenitor cells represents a potential therapeutic approach for a variety of inherited lung diseases. Crucial to the success of such a therapeutic strategy is that the transplanted cells and their progeny are correct Health and Human Services, Department of / National Institutes of Health 4/08/2010
CONTEMPORARIES, INC. $8,940 Contract : Provide support for the collection, analysis, writing and reporting of information and data on programs and projects funded by the NIH Common Fund. these products and information will help the OSC achieve its role in disseminating information to the publ Health and Human Services, Department of / National Institutes of Health 5/05/2010
RESEARCH TRIANGLE INSTITUTE $150,589 Grant Trans-NIH Recovery Act Research Support: This award was funded to support 1 full time employee and 1 part time graduate-level intern in the field of public health research. The positions will be assigned to assist in the implementation of ongoing HIV research activities to support the collection Health and Human Services, Department of / National Institutes of Health 6/14/2010
UNIVERSITY OF MASSACHUSETTS $87,688 Grant Trans-NIH Recovery Act Research Support: The overall goal of the administrative supplement is to achieve more quickly the goals of this clinical trial through the hiring of additional personnel, thereby accelerating the tempo of this funded project as well as promoting job creation. Specifically Health and Human Services, Department of / National Institutes of Health 4/16/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $3,697,235 Grant Trans-NIH Recovery Act Research Support: We propose to purchase and operate a high performance computing facility, the Orchestra Supercomputer, as a shared resource for 25 investigators (24 of whom are currently NIH funded) housed in several different institutions in Boston. This request is a re Health and Human Services, Department of / National Institutes of Health 5/06/2010
TRUSTEES OF TUFTS COLLEGE INC $487,867 Grant Trans-NIH Recovery Act Research Support: This application requests funds for the purchase of a new Nikon confocal microscope for use by neuroscientists and others at Tufts University School of Medicine (TUSM). An existing Leica TCS SP2 confocal microscope at Tufts is heavily used, eight years ol Health and Human Services, Department of / National Institutes of Health 5/27/2010
THE VANDERBILT UNIVERSITY $500,000 Grant Trans-NIH Recovery Act Research Support: We request funds to purchase a Perkin Elmer Opera LX microscope for fully automated, point-scanning confocal, high-throughput microplate imaging. Conventional inverted and confocal microscopes, plate readers and high-throughput scanners at Vanderbilt Univ Health and Human Services, Department of / National Institutes of Health 5/13/2010
UNIVERSITY OF MARYLAND $476,632 Grant Trans-NIH Recovery Act Research Support: The traditional view of protein evolution has been that all protein domains are descendents of distinct evolutionary lines, that there are a relatively small number of such lines (about 1000), and that these lines are all of relatively ancient origin. Two Health and Human Services, Department of / National Institutes of Health 9/29/2009
UNIVERSITY OF SOUTHERN CALIFORNIA $65,462 Grant Trans-NIH Recovery Act Research Support: Microarray gene expression profiling is performed in many laboratories, resulting in the rapid data accumulation in public repositories. However, due to the existence of different technology platforms and the lack of standard experimental protocols, syste Health and Human Services, Department of / National Institutes of Health 4/16/2010
ORACLE AMERICA, INC. $98,327 Contract : This is a task order to accept the CHANGE ORDER under Ordering Dcoument No. US-1339640-OD-23-SEP-2009, Ordering Dcoument Amendment Two (ODA-2) to partially exercise Option Year One early of RECOVERY - Task Order No. HHSN-276-2009-00527U and add additional Health and Human Services, Department of / National Institutes of Health 5/26/2010
GEORGETOWN UNIVERSITY (THE) $230,250 Grant Trans-NIH Recovery Act Research Support: Aging and aging associated diseases are likely to impart staggering health care costs upon the nation. Hence, there is a critical need to better understand biological aging through the characterization of the molecular changes associated with the aging pr Health and Human Services, Department of / National Institutes of Health 6/04/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $52,750 Grant Trans-NIH Recovery Act Research Support: Immunoglobulin (Ig) gene diversification is required for an effective antibody response toward pathogens. A single protein, activation-induced deaminase (AID), triggers Ig gene diversification by the distinct processes of somatic hypermutation (SHM), clas Health and Human Services, Department of / National Institutes of Health 6/11/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $33,717 Grant Trans-NIH Recovery Act Research Support: This study will compare the effects of 24 months of a multiple risk factor reduction program vs enhanced standard care on walking distance and endothelial function in PAD patients. Note: A relinquishing statement has been submitted to NIH with an early en Health and Human Services, Department of / National Institutes of Health 5/13/2010
COLORADO SEMINARY $372,732 Grant Trans-NIH Recovery Act Research Support: The general goal of this project is to develop a new synthetic methodology where high yielding photochemical key reactions are incorporated into a diversity-oriented split-and-pool combinatorial synthesis. Photochemistry offers a range of spectacular ske Health and Human Services, Department of / National Institutes of Health 4/19/2010
RESEARCH FOUNDATION FOR MENTAL HYGIENE INC $434,500 Grant Trans-NIH Recovery Act Research Support: Gene expression studies in schizophrenia have identified a number of transcripts that have altered expression in the cerebral cortex, especially those involved in GABA-ergic and glutamatergic neurotransmission. The goal of this project is to place those Health and Human Services, Department of / National Institutes of Health 5/01/2009
UNIVERSITY OF MARYLAND $72,289 Grant Trans-NIH Recovery Act Research Support: Chlamydial polymorphic membrane proteins (Pmps) are a newly identified family of Chlamydia-specific membrane proteins, whose role in chlamydial biology and pathogenesis is unknown. Genomic analysis of the pmp family of C. pneumoniae have revealed frameshi Health and Human Services, Department of / National Institutes of Health 5/10/2010
UNIVERSITY OF ALABAMA IN HUNTSVILLE $436,084 Grant Trans-NIH Recovery Act Research Support: The objective of this proposal is to develop the aromatic amino acids that have specifically incorporated 13C in their side chains. This methodology provides isolated 1H-13C spin systems for the solution structure analysis of large macromolecular systems Health and Human Services, Department of / National Institutes of Health 4/01/2010
UNIVERSITY OF WASHINGTON $99,898 Grant Trans-NIH Recovery Act Research Support: This administrative supplement is for the purchase of a Typhoon Trio Variable Mode Imager. The proposed studies are to expand the scope ofthe parent NIH grant to include multi-plex analysis of the in vivo targets of clinical kinase inhibitors. Furthermore Health and Human Services, Department of / National Institutes of Health 6/04/2010
THE INSTITUTE FOR CANCER RESEARCH $866,366 Grant Trans-NIH Recovery Act Research Support: Title: Molecular Triggers of T Helper Lineage Choice Abstract: Differentiation of thymocytes into alternate T killer and helper lineages is of great interest, due to its importance in shaping the T cell compartment and as a paradigm of binary lineage deci Health and Human Services, Department of / National Institutes of Health 5/21/2009
UNIVERSITY OF KENTUCKY $99,633 Grant Trans-NIH Recovery Act Research Support: Lipids are intermediates in energy metabolism, structural components of biological membranes and as intra- and extra- cellular signals. Aberrant lipid metabolism plays a central role human pathophysiologies, including cardiovascular disease, obesity, dia Health and Human Services, Department of / National Institutes of Health 4/23/2010
PURDUE UNIVERSITY $441,124 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Prenatal exposure to endocrine disrupting chemicals (EDCs) can result in irreversible changes in tissue differentiation and long-term reproductive potential of offspring. These changes are not usually evident until sex Health and Human Services, Department of / National Institutes of Health 6/11/2010
UNIVERSITY OF NOTRE DAME DU LAC $64,635 Grant Trans-NIH Recovery Act Research Support: Erythrocyte modifications by malaria parasite proteins are linked to both disease severity and infection. Essential modifications include the development of novel tubovesicular network (TVN) pathway linked to the import of host rafts, nutrients and drugs Health and Human Services, Department of / National Institutes of Health 4/12/2010
YALE UNIVERSITY $121,484 Grant Trans-NIH Recovery Act Research Support: Performance Indices of Social Disability in Toddlers with Autism' - addresses Challenge Area '(04) Clinical Research' and Specific Challenge Topic 'Autism: Addressing the Challenge (04-MH-101*)'; and Challenge Area '(01) Behavior, Behavioral Change, and P Health and Human Services, Department of / National Institutes of Health 5/18/2010
TRUSTEES OF INDIANA UNIVERSITY $8,386,919 Grant Trans-NIH Recovery Act Research Support: This goal of this project is to substantially enhance the childrenG??s health research facilities and to create a core facility of pediatric phenotyping laboratories and patient research resource at Indiana University. The ChildrenG??s Health Research and Health and Human Services, Department of / National Institutes of Health 3/31/2010
NEW YORK UNIVERSITY (INC) $485,500 Grant Trans-NIH Recovery Act Research Support: The DNA Sequencing Facility within the Skirball Institute at New York University Langone Medical Center provides sequencing services to about 200 labs and hundreds of scientists in the NYU community. As a core facility, the sequencing lab offers state-of- Health and Human Services, Department of / National Institutes of Health 3/25/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $224,353 Grant Trans-NIH Recovery Act Research Support: Central apnea and dysrhythmia is typical for sleep apnea and Rett Syndrome patients as well as Sudden Infant Death Syndrome victims. Since respiratory pacemakers are likely to underlie respiratory rhythmogenesis (Pena et al. 2004), investigating their pro Health and Human Services, Department of / National Institutes of Health 7/16/2009
THE HOSPITAL FOR SPECIAL SURGERY FUND INC $437,916 Grant Trans-NIH Recovery Act Research Support: Defects in the appropriate regulation of T cell function and homeostasis are fundamental to the pathogenesis of Systemic Lupus Erythematosus (SLE). Classically, SLE exhibits a striking gender bias and preferentially affects women. Although sex hormones, Health and Human Services, Department of / National Institutes of Health 6/04/2010
OHIO STATE UNIVERSITY, THE $414,998 Grant Trans-NIH Recovery Act Research Support: This grant application is requesting funding to purchase a Matrix-Assisted Laser Desorption/Ionization Time-of- Flight tandem mass spectrometer (4800 Plus MALDI-TOF/TOF-MS) from Applied Biosystems (AB) for lipidomic and glycomic research, critical in evol Health and Human Services, Department of / National Institutes of Health 4/22/2010
UNIVERSITY OF PITTSBURGH THE $2,221,266 Grant Trans-NIH Recovery Act Research Support: Project 1: The development of new ideas and approaches to understanding the mechanisms of natural HIV-1 resistance. In collaboration with the University of Washington, we hypothesize that HIV-1 infection in high risk seronegatives (HRSN) is below the dete Health and Human Services, Department of / National Institutes of Health 5/03/2010
THUNDERCAT TECHNOLOGY, LLC $120,601 Contract : NetApp DS14A-R5 Shelf Model/Cabinet/Drives. System includes all the components. Health and Human Services, Department of / National Institutes of Health 6/02/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $112,711 Grant Trans-NIH Recovery Act Research Support: In the first project, we revealed that superoxide is produced not only from semiflavin site but also more from the semiquinone site, which is completely new. In addition, quinone binding site inhibitors kill semiquinone signal, but electrons dynamically m Health and Human Services, Department of / National Institutes of Health 4/23/2010
UNIVERSITY OF MASSACHUSETTS $441,200 Grant Trans-NIH Recovery Act Research Support: The goal of this proposal is to acquire funds to purchase a Scanco VivaCT 75 high speed in vivo CT instrument to be shared by 8 investigators on the University of Massachusetts Medical School campus. Health and Human Services, Department of / National Institutes of Health 5/20/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $217,161 Grant Trans-NIH Recovery Act Research Support: GTP cyclohydrolase I (GCH-1) is the rate-limiting enzyme in the biosynthesis of BH4, an essential cofactor for endothelial nitric oxide synthase (NOS3). BH4 depletion uncouples NOS activity, which is characterized by superoxide anion generation rather tha Health and Human Services, Department of / National Institutes of Health 7/16/2009
UNIVERSITY OF MASSACHUSETTS $31,894 Grant Trans-NIH Recovery Act Research Support: One goal of our R01 supported research is to produce monoclonal antibody populations derived from immunologically humanized mice immunized with test HIV vaccine candidates . Our original strategy was to use conventional hybridization techniques employing Health and Human Services, Department of / National Institutes of Health 6/01/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $433,874 Grant Trans-NIH Recovery Act Research Support: This proposal aims to define the role of ADCC in HIV- 1 infection to determine whether the generation of these responses should be a priority in our efforts to design an effective prophylactic or therapeutic vaccine. Health and Human Services, Department of / National Institutes of Health 5/24/2010
UNIVERSITY OF ROCHESTER $40,347 Grant Trans-NIH Recovery Act Research Support: G proteins 23 subunits play a central role in G-protein coupled receptor (GPCR)- mediated signal transduction. They act as cofactors in the receptor-mediated activation process as well as playing direct roles in signal transfer to downstream targets. Cons Health and Human Services, Department of / National Institutes of Health 4/09/2010
WESTERN WASHINGTON UNIVERSITY $391,869 Grant Trans-NIH Recovery Act Research Support: The long term goal of this research is to investigate the role of novel phenomenon called locally-induced propagating synaptic(L-IPS) translocation of calcium kinase II (CaMKII). This heterosynaptic process can be described as a slow, wave-like propagati Health and Human Services, Department of / National Institutes of Health 4/01/2010
UNIVERSITY OF KENTUCKY $222,359 Grant Trans-NIH Recovery Act Research Support: This is a proposal establishes laser microdissection instrumentation using Laser Microdissection and Pressure Catapulting (LMPC) technology at the University of Kentucky. Laser microdissection technology has become a standard for cutting-edge biomedical r Health and Human Services, Department of / National Institutes of Health 4/22/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $330,724 Grant Trans-NIH Recovery Act Research Support: This award seeks to support the purchase of an Agilent 6460 Triple Quadrupole (QqQ)mass spectrometry system to be used by ten NIH-supported major users at Weill Cornell Medical College and many minor useres for quantification of important biomolecules. T Health and Human Services, Department of / National Institutes of Health 5/06/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $494,553 Grant Trans-NIH Recovery Act Research Support: Funds will be used to purchase and operate a high performance storage cluster as a shared resource for investigators at multiple institutions in the Boston area. The storage cluster will be customized to the needs of a growing community of microscopists i Health and Human Services, Department of / National Institutes of Health 5/20/2010
EMMES CORPORATION, THE $549,996 Contract : The focus of this initiative is to implement and evaluate a reengineered process to improve the timelines involved in activating NCI-sponsored Cooperative Group phase 3 trials and in activating CTEP-held IND studies of all phases, as well as investigator- Health and Human Services, Department of / National Institutes of Health 3/25/2010
NATIONAL CHILDHOOD CANCER FOUNDATION $498,467 Grant Trans-NIH Recovery Act Research Support: This supplemental award supports the development and implementation of a Childhood Cancer Modular Protocol Development System to facilitate OEWG - CTEP recommended protocol development timelines. Health and Human Services, Department of / National Institutes of Health 5/28/2010
UNIVERSITY OF CONNECTICUT $989,922 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to develop, implement and sustain community linked infrastructure that will address oral health disparities among low income older adults living in senior housing complexes in North Central Connecticut. The ultimate goal is to Health and Human Services, Department of / National Institutes of Health 5/14/2010
MAGEE-WOMENS HEALTH CORPORATION $60,000 Grant Trans-NIH Recovery Act Research Support: Abstract Spermatogonial stem cells (SSCs) are at the foundation of mammalian spermatogenesis. In rodents, the SSC pool is comprised of type Asingle (As) spermatogonia that balance self-renewing and differentiating divisions to exactly meet the biological Health and Human Services, Department of / National Institutes of Health 7/29/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $223,313 Grant Trans-NIH Recovery Act Research Support: This competing renewal investigates the involvement of the protein tyrosine phosphatase family of diabetic autoantigens, phogrin (IA-2 beta) and ICA-512 (IA-2) and their invertebrate homologs as targets of T-cells and antibodies in type 1diabetes in the N Health and Human Services, Department of / National Institutes of Health 4/12/2010
OAKLAND UNIVERSITY $107,845 Grant Trans-NIH Recovery Act Research Support: The funds awarded support purchase of a Zeiss Motorized Axio Imager Z1 Fluorescence Microscope. The equipment will support research to find the causes and seek cures for certain common diseases of aging including glaucoma, cataract, age-relate Health and Human Services, Department of / National Institutes of Health 5/27/2010
UNIVERSITY OF WISCONSIN SYSTEM $95,433 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Growth cone guidance is critical for the establishment of appropriate connectivity among neurons and failures in this process can result in psychiatric and neurological disease. Several extracellular guidance cues and Health and Human Services, Department of / National Institutes of Health 5/11/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $5,624 Grant Trans-NIH Recovery Act Research Support: ARRA- Carolina Population Center - Supplement 3-R24-HD050924-05S1 Sophia Duong June 7, 2010 - present With support from the Summer Research Experience supplement, we proposed and implemented a summer internship program, in 2009 and 2010, to involve under Health and Human Services, Department of / National Institutes of Health 4/22/2010
RUSH UNIVERSITY MEDICAL CENTER $59,610 Grant Trans-NIH Recovery Act Research Support: This award provided research experience for an hispanic male for his second year after graduating from college while applying to graduate schools. Health and Human Services, Department of / National Institutes of Health 6/10/2010
AUBURN UNIVERSITY $15,476 Grant Trans-NIH Recovery Act Research Support: There is increasing use of soy products in the diet of the population and especially as non dairy sources of protein and in individuals with milk allergy. However, soy beans contain compounds called phytochemicals, which have the capacity to act in the sa Health and Human Services, Department of / National Institutes of Health 6/17/2010
DUKE UNIVERSITY $26,401 Grant Trans-NIH Recovery Act Research Support: Although several clinical trials have identified interventions that reduce adverse outcomes such as falls in nursing home (NH) residents, attempts to translate those interventions into practice using widely accepted quality improvement (QI) techniques hav Health and Human Services, Department of / National Institutes of Health 5/13/2010
AKAZA RESEARCH, LLC $289,771 Grant Trans-NIH Recovery Act Research Support: We believe a key barrier to transforming clinical research is the lack of open, integrated, transparent technology solutions that address bottlenecks in information integration and business process management. Our viewpoint is supported by a recent Forres Health and Human Services, Department of / National Institutes of Health 6/10/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $400,000 Grant Trans-NIH Recovery Act Research Support: Mast cells, macrophages, and polymorphonuclear leukocytes (PMN), initiate and amplify inflammation in the lung by synthesizing and releasing the bioactive lipids leukotriene (LT)B4, and LTC4. After its release from cells, LTC4 is converted to LTD4. These Health and Human Services, Department of / National Institutes of Health 6/28/2010
JOHNS HOPKINS UNIVERSITY, THE $88,235 Grant Trans-NIH Recovery Act Research Support: Diabetes Research and Training Center This application is in response to the NIH Notice NOT-OD-09-056. The Baltimore DRTC requests supplemental funding of programs that will benefit its ongoing mission to understand and treat diabetes and related diseases Health and Human Services, Department of / National Institutes of Health 5/10/2010
UNIVERSITY OF CALIFORNIA, DAVIS $1,406,880 Grant Trans-NIH Recovery Act Research Support: The purpose of this award is to purchase a commercial super-resolution light (optical) microscope and install it in the MCB Imaging Facility. Here it will be available to the Principal Investigators of the award and other users of this imaging facility. Health and Human Services, Department of / National Institutes of Health 5/06/2010
ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE $147,262 Grant Trans-NIH Recovery Act Research Support: This proposal requests funds to purchase a robot to set up crystallization experiments for the Structural Biology Resource Center at The Rockefeller University. The robot will aid researchers in obtaining diffraction quality crystals of biological macromo Health and Human Services, Department of / National Institutes of Health 4/15/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $1,200,483 Grant Trans-NIH Recovery Act Research Support: This application requests funds to purchase a Leica SP5X 2-photon laser-scanning confocal microscope system for the University of Michigan campus in Ann Arbor, Michigan. Currently there is no 2-photon confocal microscope system for shared use at the Univ Health and Human Services, Department of / National Institutes of Health 5/06/2010
SECOND SIGHT MEDICAL PRODUCTS, INC. $2,988,224 Grant Trans-NIH Recovery Act Research Support: Second Sight Medical Products, Inc. (SSMP) has been developing retinal prostheses for over 10 years. Currently, the company is sponsoring a feasibility clinical trial for its Argus II system-a 60 electrode retinal prosthesis to treat advanced retinitis p Health and Human Services, Department of / National Institutes of Health 4/23/2010
OKLAHOMA STATE UNIVERSITY $436,143 Grant Trans-NIH Recovery Act Research Support: Diseases of iron metabolism continue to be a major health concern in the United States. Iron deficiency remains the most common single nutrient deficiency in the US and individuals experience negative health consequences due to iron deficiency in the abse Health and Human Services, Department of / National Institutes of Health 4/30/2010
DANCING DOTS BRAILLE MUSIC TECHNOLOGY, L.P. $200,000 Grant Trans-NIH Recovery Act Research Support: The Talking Tactile Tablet (TTT) is a well established, multimedia PC peripheral for teaching literary braille. This project explores the feasibility of displaying tactile images of print music notation and braille music symbols on the TTT hardware. Resul Health and Human Services, Department of / National Institutes of Health 4/23/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $938,896 Grant Trans-NIH Recovery Act Research Support: Using forward genetics in zebrafish and pedigree/patient DNA sequence analysis in humans, we will identify complex genetic interactions that contribute to phenotypes associated with primary open angle glaucoma. The glaucomas are a group of vision impairin Health and Human Services, Department of / National Institutes of Health 9/30/2009
ST. JUDE CHILDREN'S RESEARCH HOSPITAL $2,772,027 Grant Trans-NIH Recovery Act Research Support: A high-end instrumentation grant is requested to purchase a research- dedicated 3.0 T Siemens Verio MRI scanner for human translational and clinical imaging research at St. Jude Children's Research Hospital. St. Jude is a charitably funded institution ded Health and Human Services, Department of / National Institutes of Health 5/20/2010
TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER $33,413 Grant Trans-NIH Recovery Act Research Support: The research project is on the development of a vaccine against schistosome infection which affects over 200 million people with an additional 790 million at risk in 74 countries. Two High School Biology teachers from Lubbock High School will work as Res Health and Human Services, Department of / National Institutes of Health 6/14/2010
UNIVERSITY OF WASHINGTON $288,600 Grant Trans-NIH Recovery Act Research Support: We request funds to purchase a state-of-the-art robotic arm and hand fromShadow Robot Ltd. The robot is actuated by 48 air muscles whose complianceand force-length characteristics are similar to human muscles. Its kinematicstructure and range of motion ar Health and Human Services, Department of / National Institutes of Health 5/13/2010
UNIVERSITY OF FLORIDA $209,220 Grant Trans-NIH Recovery Act Research Support: Numerous factors have contributed to the failure to produce a successful small diameter vascular graft. It is clear that a working graft must include a cellular component since inert materials are unable to interact appropriately with the surrounding tiss Health and Human Services, Department of / National Institutes of Health 4/14/2010
FORSYTH DENTAL INFIRMARY FOR CHILDREN $279,295 Grant Trans-NIH Recovery Act Research Support: The Forsyth Institute proposes to obtain a Zeiss Evo LS 10 scanning electron microscope (SEM) equipped with an Oxford INCA Energy 250 energy dispersive x-ray elemental analysis system (EDS. The purpose is to replace 20 year old SEM with deteriorating func Health and Human Services, Department of / National Institutes of Health 6/10/2010
EKOS CORPORATION $2,794,833 Grant Trans-NIH Recovery Act Research Support: Non-traumatic IntraCerebral Hemorrhage (ICH) is caused by a rupture of vessels which bleed directly into the brain tissue, forming a gradually enlarging hematoma (pooling of blood). In 40% of ICH cases, the ICH is associated with bleeding into the ventric Health and Human Services, Department of / National Institutes of Health 5/24/2010
CASE WESTERN RESERVE UNIVERSITY $963,378 Grant Trans-NIH Recovery Act Research Support: These experiments are deisgned to utilize the rhesus vaginal challenge model to explore the plausibility of two distinct hypotheses regarding the determinants of protection from HIV infection among persons exsposed to HIV infection but who have remained u Health and Human Services, Department of / National Institutes of Health 5/10/2010
AUDIOLOGY INC $1,970,866 Grant Trans-NIH Recovery Act Research Support: This project will continue the development, validation, and commercialization efforts of Audiology Incorporated to develop hearing testing products that will increase access, efficiency, and accuracy of hearing tests. The methods are based on behavioral s Health and Human Services, Department of / National Institutes of Health 4/08/2010
TUFTS MEDICAL CENTER, INC. $56,727 Grant Trans-NIH Recovery Act Research Support: The administrative supplement requested is to cover the costs associated with continuing the scientific research funded under our initial grant in addition to achieving all originally related research objectives within the original scope of the project. P Health and Human Services, Department of / National Institutes of Health 5/25/2010
SOUTH CAROLINA RESEARCH FOUNDATION $42,819 Grant Trans-NIH Recovery Act Research Support: Use of a Community-University Partnership to Eliminate Environmental Stressors Undergraduate students from the University of South Carolina (USC) and two Historically Black Colleges in Columbia, SC, Benedict College and Allen University, will participate Health and Human Services, Department of / National Institutes of Health 5/28/2010
OREGON HEALTH & SCIENCE UNIVERSITY $96,540 Grant Trans-NIH Recovery Act Research Support: Funds are requested to increase hours of current part-time staff to enable this program to retain two research technicians. These additional funds will allow us to avoid layoff of key personel, since these two postions currently are also supported by oth Health and Human Services, Department of / National Institutes of Health 4/08/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $99,424 Grant Trans-NIH Recovery Act Research Support: Molecular Mechanisms of CFTR Function This was an equipment supplemental award to provide replacement instrumentation for an ongoing NIH research grant investigating the CFTR protein ion channel as well as new cutting edge equipment to facilitate and acce Health and Human Services, Department of / National Institutes of Health 5/24/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO $359,080 Grant Trans-NIH Recovery Act Research Support: The instrument requested in this application is an ultra-high resolution microscopic computed tomography (microCT) scanner to evaluate 3-dimensional bone and soft tissue architecture from ex vivo specimens. This instrument, a Skyscan 1172 microCT scanner, Health and Human Services, Department of / National Institutes of Health 5/06/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $98,393 Grant Trans-NIH Recovery Act Research Support: The supplement will accelerate progress towards the original aims of research on the determinants of schistosomiasis reemergence in southwest China by hiring a post-doctoral researcher. Through the addition of staff, this supplement will allow a more rapi Health and Human Services, Department of / National Institutes of Health 6/21/2010
ALBANY MEDICAL COLLEGE $351,986 Grant Trans-NIH Recovery Act Research Support: This is a request for a Zeiss Laser Total Internal Reflection Fluorescence (TIRF) microscope and live cell imaging system that will permit a group of 5 researchers at the Albany Medical College and 1 at the SUNY School of Public Health to selectively imag Health and Human Services, Department of / National Institutes of Health 4/22/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $162,048 Grant Trans-NIH Recovery Act Research Support: This shared instrument proposal is for an inverted epifluorescence microscope outfitted for, and dedicated to, time-lapse imaging of bacteria. The users are a group of microbiologists whose research is focused on fundamental and outstanding problems in ba Health and Human Services, Department of / National Institutes of Health 4/22/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $1,309,694 Grant Trans-NIH Recovery Act Research Support: This supplement award to the UCLA MACS award is comprised of 3 projects Project 1: Rita Effros: Accelerated aging in HIV/AIDS: refining the molecular/genetic signature of senescent CD8+ T cells This addresses the broad area of premature immunological a Health and Human Services, Department of / National Institutes of Health 5/03/2010
CHILDREN'S HOSPITAL MEDICAL CENTER $305,862 Grant Trans-NIH Recovery Act Research Support: The Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study was funded in 2006 as an ancillary to the adult Longitudinal Assessment of Bariatric Surgery (LABS) study. A primary goal of Teen-LABS is the accurate and objective assessment of ris Health and Human Services, Department of / National Institutes of Health 6/19/2010
BIOMERIEUX , INC. $67,971 Contract : easyMAG Nucli SENS System & easyMAG Cart Health and Human Services, Department of / National Institutes of Health 4/21/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $100,001 Grant Trans-NIH Recovery Act Research Support: We request supplemental funds to investigate the role played by acetylation and sumoylation in the potentiation of transcriptionally active chromatin by HNF3. The goal of the parent grant DK073641 is to determine how G?pioneerG? or initial chromatin bind Health and Human Services, Department of / National Institutes of Health 1/19/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $436,391 Grant Trans-NIH Recovery Act Research Support: Disorders of iron metabolism, either genetically-determined or secondary to other illnesses, are relatively common cllinical problems. Our preliminary studies with Hfe knock-out (KO) mice, a model of human type I hemochromatosis, have revealed that the ab Health and Human Services, Department of / National Institutes of Health 6/21/2010
RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL $265,937 Grant Trans-NIH Recovery Act Research Support: This ARRA supplement was received in order to hire a computer programming specialist to develop tools for analysis of genetic and genomic information within the Utah Genome Center databases. These tools will be publicly available on the Utah genome Center Health and Human Services, Department of / National Institutes of Health 6/30/2010
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH $425,000 Grant Trans-NIH Recovery Act Research Support: The Sloan Kettering Institute requests a SOLiD 3 sequencer. This instrument will be used by scientists to sequence whole or parts of genomes at incredible depth and with extreme accuracy. This instrument will enable various biological applications such as Health and Human Services, Department of / National Institutes of Health 4/15/2010
DUKE UNIVERSITY $423,066 Grant Trans-NIH Recovery Act Research Support: We are requesting a versatile system to improve our ability and capacity for a variety of live cell imaging projects. The instrument would be located in the Light Microscopy Core Facility (LMCF), a large established core that serves over 550 users across Health and Human Services, Department of / National Institutes of Health 4/22/2010
UNIVERSITY OF LOUISIANA AT MONROE $426,000 Grant Trans-NIH Recovery Act Research Support: The Mechanisms of Early Growth Response Factor 1 (Egr-1) Induction by HSV-1 Lytic IND Health and Human Services, Department of / National Institutes of Health 4/23/2010
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC $496,368 Grant Trans-NIH Recovery Act Research Support: In response to PAR-09-028: Shared Instrumentation Grant Program (S10), this application requests support for a state-of-the-art BioScope Catalyst Atomic Force Microscope (AFM) system (Veeco Instruments, Plainview, NY) integrated with a new Olympus IX81 in Health and Human Services, Department of / National Institutes of Health 4/22/2010
WHITEHEAD INSTITUTE FOR BIO-MEDICAL RESEARCH $90,000 Grant Trans-NIH Recovery Act Research Support: The experimental aims of the parent award were conceived following the hypothesis that Dm ime4, Drosophila homolog of yeast IME4, that will serve as a stepping stone for the study of this gene in metazoans, had a similar function to that of its yeast coun Health and Human Services, Department of / National Institutes of Health 6/11/2010
BATTELLE MEMORIAL INSTITUTE $99,846 Grant Trans-NIH Recovery Act Research Support: Award Title: Proteomics Studies of Type 2 Diabetes Using Knockout Mouse Models Award Purpose: This supplement will accelerate the research tempo of the parent award by including mouse models of insulin resistance and by implementing newer technologies Health and Human Services, Department of / National Institutes of Health 4/15/2010
SETON HALL UNIVERSITY $322,609 Grant Trans-NIH Recovery Act Research Support: The main goal of our research is to investigate the role of interleukin (IL)-1? in maternal infection-induced alterations of offspring neuroinflammation. There is significant evidence that maternal infection is a significant risk factor for the pathogene Health and Human Services, Department of / National Institutes of Health 6/24/2010
UNIVERSITY OF ILLINOIS $956,609 Grant Trans-NIH Recovery Act Research Support: Diabetes, especially type 2, has been identified as an epidemic in the U.S. and is continuing to grow in prevalence. The burden of diabetes, including prevalence and risk of complications, is greater for low-income individuals and minority groups, especia Health and Human Services, Department of / National Institutes of Health 8/19/2010
WHITEHEAD INSTITUTE FOR BIO-MEDICAL RESEARCH $499,839 Grant Trans-NIH Recovery Act Research Support: These funds will be used to purchase a Zeiss LSM710 scanning confocal microscope, to be made available to both Whitehead and MIT investigators. Scanning confocal microscopes allow optical sectioning of living and fixed material, so that investigators can Health and Human Services, Department of / National Institutes of Health 5/13/2010
VITAL IMAGES INC $346,752 Contract : This project is to upgrade National Institute of Health facilities to Vitrea Enterprise Suite advanced visualization software, which will give access to all of Vital Images' advanced visualization tools throughout the National Institute of Health enterpri Health and Human Services, Department of / National Institutes of Health 12/29/2009
MEDICAL COLLEGE OF WISCONSIN, INC., THE $927,390 Grant Trans-NIH Recovery Act Research Support: Endothelial cells (EC) release several factors that reduce vascular tone and counteract vasoconstriction including nitric oxide (NO) and prostaglandin (PG) I2. In the rabbit aorta and mouse mesenteric artery, endothelium-dependent relaxations to acetylcho Health and Human Services, Department of / National Institutes of Health 8/31/2009
ARCHITECTS DESIGN GROUP PC $117,000 Contract : A&E Services; funds global travel for support at RML Health and Human Services, Department of / National Institutes of Health 2/17/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $358,131 Grant Trans-NIH Recovery Act Research Support: A. Introduction and specific aims The human immunodeficiency virus (HIV) causes a lethal syndrome (acquired immunodeficiency syndrome) characterized by CD4+ T cell depletion and resultant immunodeficiency. HIV has caused a worldwide epidemic that has ki Health and Human Services, Department of / National Institutes of Health 6/07/2010
UNIVERSITY OF KENTUCKY $297,087 Grant Trans-NIH Recovery Act Research Support: The long-term objectives of our 12 federal grants (R01-type) are to address important and unique problems in neuroscience and cardiac physiology, including a better understanding how living cells in the nervous system and heart respond to drugs or other c Health and Human Services, Department of / National Institutes of Health 5/13/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $101,824 Grant Trans-NIH Recovery Act Research Support: This proposal is for an Administrative Supplement to the approved and funded R01 DK 077949, ?Nutrition and Metabolic Status in Youth with Type 1 DM: SEARCH Ancillary Study (SNAS)? using the NIDDK FY 2009 Program for Administrative Supplements Utilizing Re Health and Human Services, Department of / National Institutes of Health 4/13/2010
UNIVERSITY OF NORTH DAKOTA $29,160 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The overall goal of the present work is to characterize the cell and molecular mechanisms that regulate neural and vascular cell interactions during development. The central objective of this work is to determine the Health and Human Services, Department of / National Institutes of Health 7/17/2009
MEDICAL COLLEGE OF WISCONSIN, INC., THE $778,000 Grant Trans-NIH Recovery Act Research Support: CD4+CD25+ regulatory T (Treg) cells express the forkhead transcription factor Foxp3 and are essential for the maintenance of dominant immunological tolerance to the G??extended selfG??, which includes self proteins and the commensal microbial flora. Glob Health and Human Services, Department of / National Institutes of Health 8/11/2009
BAYLOR RESEARCH INSTITUTE, THE $1,322,064 Grant Trans-NIH Recovery Act Research Support: Vaccination represents one of the major successes of medicine as it has spared countless people from polio, tetanus and other acute infections. Yet, improved immunization strategies are needed to make vaccines for microbes that cause considerable morbidit Health and Human Services, Department of / National Institutes of Health 6/28/2010
UNIVERSITY OF NEBRASKA $755,826 Grant Trans-NIH Recovery Act Research Support: A Computational Genotyping System for Improved Influenza Surveillance. The long-term goal of this research is to better understand how influenza A viruses evolv, spread, and cause disease, so that enhanced diagnoses and ultimately control strategies for i Health and Human Services, Department of / National Institutes of Health 7/22/2010
MASSACHUSETTS INSTITUTE OF TECHNOLOGY $9,744 Grant Trans-NIH Recovery Act Research Support: This grant provided a summer research experience for one college student in health-related scientific research. Health and Human Services, Department of / National Institutes of Health 7/30/2010
THE GEORGE WASHINGTON UNIVERSITY $32,771 Grant Trans-NIH Recovery Act Research Support: We request supplemental support for our project G?Regional Differentiation during Forebrain DevelopmentG? to accelerate research that will define the niche and transcriptional network necessary for specification of olfactory epithelial (OE) neural stem c Health and Human Services, Department of / National Institutes of Health 8/12/2010
CHILDREN'S HOSPITAL MEDICAL CENTER $318,670 Grant Trans-NIH Recovery Act Research Support: Achieving the aims described in this application will inform the development of interventions designed to improve early breastfeeding outcomes among obese women. These efforts potentially have great public health impact given the high prevalence of obesit Health and Human Services, Department of / National Institutes of Health 9/01/2010
SAINT LOUIS UNIVERSITY $375,000 Grant Trans-NIH Recovery Act Research Support: Approximately 12-20 million people are infected with T. cruzi and 50,000 people die each year from Chagas disease. People in the US are at risk of T. cruzi infection through blood transfusions and organ donations originating from infected persons, and the Health and Human Services, Department of / National Institutes of Health 8/02/2010
CHILDRENS HOSPITAL OF PHILADELPHIA $55,828 Grant Trans-NIH Recovery Act Research Support: The clinical profiles of several developmental disorders, including autism spectrum disorders (ASD), involve varying degrees of comorbid language impairment (LI). Clinical diagnosis of LI, however, does not itself identify the associated underlying neuron Health and Human Services, Department of / National Institutes of Health 5/10/2010
MOUNT SINAI SCHOOL OF MEDICINE $657,633 Grant Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (14) Stem Cells, and specific Challenge Topic 14-DK-104: In vitro differentiation of human Embryonic Stem Cells (ES)/Induced Pluripotent Stem Cells (iPS) to NIDDK relevant cells/tissues. Hemoglobinapathies, Health and Human Services, Department of / National Institutes of Health 4/09/2010
VWR INTERNATIONAL, LLC $44,429 Contract : furniture group award per karrin. Health and Human Services, Department of / National Institutes of Health 5/19/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $2,272,128 Grant Trans-NIH Recovery Act Research Support: We propose to conduct a validation/reproducibility study to gauge the magnitudes of both systematic errors (resulting from interview-based exposure surrogates) and random errors (resulting from within-subject variation in exposure levels) of home exposure Health and Human Services, Department of / National Institutes of Health 7/16/2009
UNIVERSITY OF TENNESSEE $466,377 Grant Trans-NIH Recovery Act Research Support: The proposal is to purchase a modern confocal laser confocal scanning microscope (Zeiss LSM 710) with wide spectral scanning capability, high resolution, and high sensitivity for a Neuroscience Imaging Center at the University of Tennessee Health Science Health and Human Services, Department of / National Institutes of Health 5/13/2010
UNIVERSITY OF WISCONSIN SYSTEM $2,848,680 Grant Trans-NIH Recovery Act Research Support: The specific aim of this proposal is to obtain funding to purchase a GE Healthcare Discovery MR750 3T Human Whole-Body Magnetic Resonance Imaging (MRI) system to be installed in the Imaging Sciences Center of a newly-constructed, state-of-the-art medical Health and Human Services, Department of / National Institutes of Health 5/06/2010
UNIVERSITY OF WASHINGTON $999,999 Grant Trans-NIH Recovery Act Research Support: Heart failure commonly results from loss of heart muscle cells caused by infarction. Myocardial infarction takes millions of people's lives every year. Stem cells offer the possibility of cell replacement and cardiac repair. Current methods of studying Health and Human Services, Department of / National Institutes of Health 4/21/2010
LOUISIANA STATE UNIVERSITY SYSTEM $436,126 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Epigenetic modification is a major contributor to determining individuals' phenotype with genotype and environment. A single human genome with an identical sequence can derive several different versions of the epigenet Health and Human Services, Department of / National Institutes of Health 6/10/2010
UNIVERSITY OF CONNECTICUT $358,805 Grant Trans-NIH Recovery Act Research Support: The research that will benefit from small-scale mechanical testing is highly relevant to our efforts to develop practical methods for regenerating damaged musculoskeletal tissues using cell-friendly biomaterials. The increase in quality and quantity of r Health and Human Services, Department of / National Institutes of Health 5/13/2010
UNIVERSITY OF WISCONSIN SYSTEM $1,000,000 Grant Trans-NIH Recovery Act Research Support: The population of older adults in the United States is expected to nearly double over the next 25 years. The Institute of Medicine has stated that there is a nationwide lack of preparedness to meet the health care needs of aging 'baby boomers'. Transforma Health and Human Services, Department of / National Institutes of Health 6/14/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $213,900 Contract : Brigham and Women's has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of colon/rectal specimens (N=92). The collection of the specimens is being per Health and Human Services, Department of / National Institutes of Health 5/05/2010
TUFTS MEDICAL CENTER, INC. $157,013 Grant Trans-NIH Recovery Act Research Support: Anemia is a common complication among patients with chronic kidney disease (CKD) and traditionally erythropoietin (EPO) deficiency has been considered the major cause. It is clear however that several mechanisms including inflammation contribute to the pa Health and Human Services, Department of / National Institutes of Health 5/01/2010
WISTAR INSTITUTE OF ANATOMY & BIOLOGY $515,049 Grant Trans-NIH Recovery Act Research Support: The long-term goal of the proposal this administrative supplement supports is to study the effects of early antiretroviral therapy (ART) in HIV-infected infants and the functional reconstitution/maturation of antiviral effector mechanisms of the innate/ad Health and Human Services, Department of / National Institutes of Health 5/17/2010
BOSTON BIOMEDICAL RESEARCH INSTITUTE, INC. $425,500 Grant Trans-NIH Recovery Act Research Support: The research supported by this equipment award will increase understanding of several organ and tissue systems and functions that play significant roles in the development in human disease and aging. These include cell movement in the body tissues, muscl Health and Human Services, Department of / National Institutes of Health 3/04/2010
AR CHILDRENS HOSPITAL RESEARCH INSTITUTE $95,657 Grant Trans-NIH Recovery Act Research Support: This is a supplement to the autism is a behavioral condition defined by deficient social interaction, language and communication, and play. Children with autism can exhibit a number of behaviors including severe tantrums, noncompliance, destructiveness, a Health and Human Services, Department of / National Institutes of Health 6/26/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $207,732 Grant Trans-NIH Recovery Act Research Support: Latinos in the US carry a disproportionate burden of type-2 diabetes. Research has implicated life course socioeconomic position as a major factor in the development of chronic diseases, such as type-2 diabetes; yet most evidence is limited to non-Hispani Health and Human Services, Department of / National Institutes of Health 4/28/2010
UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) $498,750 Grant Trans-NIH Recovery Act Research Support: This application requests funding for an Illumina Genome Analyzer IIx system with an integrated data analysis server to establish a deep sequencing service at University of Medicine and Dentistry of New Jersey (UMDNJ)- New Jersey Medical School (NJMS) and Health and Human Services, Department of / National Institutes of Health 4/08/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $79,959 Grant Trans-NIH Recovery Act Research Support: Money from the ARRA supplement helped pay for the costs of mouse experiments on the gene MYH9, which causes kidney disease in rare families, and was associated in 2008-9 with common forms of kidney disease in African-Americans. The supplement money hel Health and Human Services, Department of / National Institutes of Health 5/28/2010
RESEARCH FOUNDATION FOR MENTAL HYGIENE INC $59,839 Grant Trans-NIH Recovery Act Research Support: To support research and other projects that will support fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments while also providing economic stimulus to the nation. Health and Human Services, Department of / National Institutes of Health 6/01/2009
UNIVERSITY OF MASSACHUSETTS $328,543 Grant Trans-NIH Recovery Act Research Support: This award is a competitive revision request for grant RO1 DE 007444, 'Bone matrix and bone resorption,' under which we are investigating the osteoclast cell biology of a protein we discovered called plekhm1. Evidence indicates that plekhm1 is required fo Health and Human Services, Department of / National Institutes of Health 9/23/2009
BOOZ ALLEN HAMILTON INC. $396,178 Contract : Booz Allen will provide Grants Management Lifecycle Support for ARRA Funded Grants. Health and Human Services, Department of / National Institutes of Health 5/06/2010
NORTHEAST OHIO MEDICAL UNIVERSITY $44,326 Grant Trans-NIH Recovery Act Research Support: The studies proposed are the reasonable extension of the specific aims 3 and 4 of parent grant (HL083237). The objective of studies is to develop a highly specific approach to establish the redox modification with protein S-glutathionylation and protein Health and Human Services, Department of / National Institutes of Health 4/12/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $397,591 Grant Trans-NIH Recovery Act Research Support: Olympus FV1000MPE Multiphoton Exclusive with Vision II and Chameleon (ARRA) - This award was funded for the purpose of purchasing a multiphoton microscope. Health and Human Services, Department of / National Institutes of Health 5/13/2010
X-RAY OPTICAL SYSTEMS, INC. $199,997 Grant Trans-NIH Recovery Act Research Support: X-ray fluorescence (XRF) is a powerful, nondestructive, rapid technique for elemental analysis in a wide variety of materials. There are nine elements regulated for their toxic effects world-wide, namely, Chromium (Cr), Arsenic(As), Selenium(Se), Bromine Health and Human Services, Department of / National Institutes of Health 5/01/2010
EAST TENNESSEE STATE UNIVERSITY $322,362 Grant Trans-NIH Recovery Act Research Support: Severe motor disabilities such as amyotrophic lateral sclerosis (ALS), brainstem stroke, cerebral palsy, and spinal cord injury reduce or eliminate neuromuscular control and deprive affected patients of communication and control that is vital to their men Health and Human Services, Department of / National Institutes of Health 4/09/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $760,000 Grant Trans-NIH Recovery Act Research Support: The long-term objective of the proposed research is to determine the effects of age on the susceptibility of the retinal pigment epithelium (RPE) to oxidative stress. Oxidative stress to the RPE is believed to decrease the support that the RPE provides to Health and Human Services, Department of / National Institutes of Health 7/20/2009
UNIVERSITY OF MONTANA SYSTEM $30,384 Grant Trans-NIH Recovery Act Research Support: This supplemental request is to support our collaborative effort in conducting transciptome and proteome analysis of human mucosal epithelial cells and macrophages in an effort to link those responses to in vitro assessments. We will conduct transcriptio Health and Human Services, Department of / National Institutes of Health 6/10/2010
UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) $14,883,686 Grant National Center for Research Resources, Recovery Act Construction Support: University of Medicine and Dentistry of New Jersey (UMDNJ), New Jersey Medical School (NJMS) requests funds to modernize and transform our 1975 built Central Research Animal Faculty (CRAF) so we can continue to effectively and... Show more Health and Human Services, Department of / National Institutes of Health 3/25/2010
ACCESS COMMUNITY HEALTH NETWORK $6,716,558 Grant National Center for Research Resources, Recovery Act Construction Support: Access Community Health Network (ACCESS), a 501(c)3 federally qualified health center (FQHC) organization, has secured $6.7 million under the NIH Recovery Act Limited Competition: Extramural Research Facilities Improvement Pro... Show more Health and Human Services, Department of / National Institutes of Health 4/21/2010
MIAMI UNIVERSITY $426,000 Grant Trans-NIH Recovery Act Research Support: Acquisition and maintenance of motility are important components of sperm physiology in that they play critical roles in ensuring fertility. While the roles that structural/motor proteins and ion channels play in sperm motility is under intense investiga Health and Human Services, Department of / National Institutes of Health 4/14/2010
UNIVERSITY OF HAWAII SYSTEMS $453,404 Grant Trans-NIH Recovery Act Research Support: The broad long-term goal of this proposal is to increase the representation of individuals, who are underrepresented ethnic minority or of socio-economically disadvantaged background, in biomedical and social sciences research. To this end, the University Health and Human Services, Department of / National Institutes of Health 5/21/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $1,190,132 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): We are requesting an in vivo multiphoton microscope for the UT Southwestern Live Cell Imaging Facility (LCIF), a campus wide core facility that provides access to optical microscopy instrumentation for more than 150 re Health and Human Services, Department of / National Institutes of Health 5/20/2010
TRUSTEES OF INDIANA UNIVERSITY $52,210 Grant Trans-NIH Recovery Act Research Support: The general goal of this project is to undestand the molecular basis of pathogen recognition by plants. Specifically we are characterizing how the RPS5 protein of Arabidopsis mediates recognition of the AvrPphB protein from the bacterium Pseudomonas syrin Health and Human Services, Department of / National Institutes of Health 4/23/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $441,075 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by the applicant): Cryptococcus neoformans is a major fungal pathogen for individuals with impaired immunity, including those with advanced HIV infection, organ transplants, and on immunosuppressive regimens. Furthermore, there is in Health and Human Services, Department of / National Institutes of Health 4/19/2010
INVASC THERAPEUTICS, INC. $190,703 Grant Trans-NIH Recovery Act Research Support: Alpha Lipoic Acid (ALA) is a naturally occuring fatty acid synthesized by plants and animals, including humans. ALA possesses potent antioxidant, anti-inflammatory and mitochondrial protectant properties. In studies, ALA has been demonstrated to induce Health and Human Services, Department of / National Institutes of Health 5/14/2010
INDOOR BIOTECHNOLOGIES INC $321,134 Grant Trans-NIH Recovery Act Research Support: The main goal of this supplement is to measure IgE antibody binding to specific cockroach allergens for the Inner City Asthma Consortium. As a result of this analysis, sera will be identified and used to expedite the research performed under the RO1 paren Health and Human Services, Department of / National Institutes of Health 6/28/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $302,463 Grant Trans-NIH Recovery Act Research Support: All biological functions are dependent on molecular interactions. Therefore, by studying when, where and how molecules interact, we can elucidate the fundamental principles of biology. The Principle Investigators on this grant come from three different de Health and Human Services, Department of / National Institutes of Health 5/27/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $386,250 Grant Trans-NIH Recovery Act Research Support: We have performed additional studies to understand the activation of the NLRP3 inflammasome. We found that al stimuli tested including ATP, bacterial toxins, and particulate matter (silica) induce K+ efflux. The new studies have revealed that K+ efflux is Health and Human Services, Department of / National Institutes of Health 6/21/2010
DUKE UNIVERSITY $499,775 Grant Trans-NIH Recovery Act Research Support: This is a request for a 2-photon intravital laser scanning confocal fluorescence microscopy system -intravital confocal microscope- for a variety of projects involving confocal imaging of living mice. The system will be installed in the Light Microscopy C Health and Human Services, Department of / National Institutes of Health 5/06/2010
SWARTHMORE COLLEGE $392,723 Grant Trans-NIH Recovery Act Research Support: A wide range of important human diseases are characterized by protein misfolding. In the cell, protein chaperones ensure correct folding of newly synthesized proteins as well as the refolding of stress-denatured proteins. It follows that a full understand Health and Human Services, Department of / National Institutes of Health 5/15/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $500,000 Grant Trans-NIH Recovery Act Research Support: High-resolution structures of biological molecules obtained through x-ray crystallography provide among the most important sources of data for understanding function and mechanism. However, the process of crystallization presents a major bottleneck since Health and Human Services, Department of / National Institutes of Health 6/10/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $100,000 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Hepatic insulin action: Role of the pentose cycle. Insulin, after binding to its liver receptor, initiates the activation of a signaling effector chain, via PI3-K/Akt activation, and subsequent mTOR activation, stimula Health and Human Services, Department of / National Institutes of Health 5/11/2010
TRUSTEES OF INDIANA UNIVERSITY $258,400 Grant Trans-NIH Recovery Act Research Support: Atopic dermatitis (AD) is a common allergic disease seen in 10-20% of infants. While severity often diminishes with age, AD can persist throughout life. Moreover, AD severity can be a predictor of subsequent allergic disease as 60% of children who have AD Health and Human Services, Department of / National Institutes of Health 6/28/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $96,665 Grant Trans-NIH Recovery Act Research Support: Runx2 is a master osteoblast transcription factor playing pivotal roles in skeletal development and homeostasis. In humans, Runx2 haplotypes contribute to variations in bone mass. Runx1, which is expressed in osteoblasts and shares similar DNA-binding pro Health and Human Services, Department of / National Institutes of Health 6/03/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $95,769 Grant Trans-NIH Recovery Act Research Support: G protein-coupled receptors (GPCRs) comprise the largest family of cell surface signaling receptors in the mammalian genome, mediate cellular responses to diverse stimuli and control a vast physiological responses. Dysregulated GPCR signaling has been imp Health and Human Services, Department of / National Institutes of Health 6/11/2010
NEW YORK UNIVERSITY (INC) $357,647 Grant Trans-NIH Recovery Act Research Support: This is an application for a new Conte Center for Schizophrenia Research based at the New York University School of Medicine (NYUSoM) and the affiliated Nathan Kline Institute for Psychiatric Research (NKI). Schizophrenia (SZ) is associated with sensory p Health and Human Services, Department of / National Institutes of Health 5/22/2010
DJD CONSULTING $48,000 Contract : Technical Review of Assurance and Related Documents Health and Human Services, Department of / National Institutes of Health 9/29/2009
UNIVERSITY OF CALIFORNIA, DAVIS $229,500 Grant Trans-NIH Recovery Act Research Support: Role of protein-tyrosine phosphatase 1B in pancreatic function Diabetes is one of the most prevalent metabolic diseases that is characterized by hyperinsulinemia, insulin resistance, and defect(s) in islet secretory function. Type 1 (insulin-dependent) d Health and Human Services, Department of / National Institutes of Health 6/17/2010
CEDARS-SINAI MEDICAL CENTER $48,256 Grant Trans-NIH Recovery Act Research Support: Abstract: Phagosomal targeting of CARD proteins Phagocytosis is the process by which cells such as macrophages and dendritic cells bind, internalize, and kill microbes. Several different types of receptors are known to recognize microbes (either directly Health and Human Services, Department of / National Institutes of Health 6/04/2010
UNIVERSITY OF LOUISVILLE $186,250 Grant Trans-NIH Recovery Act Research Support: The purpose of the award is to provide funds to complete data collection needed to re submit a R01 proposal to NIH. To present our proposal as more quantitative in nature a critical step will be to collect in vivo pilot data showing the effect of disrupt Health and Human Services, Department of / National Institutes of Health 6/10/2010
MAYO CLINIC $6,688 Contract : Mayo Foundation has been awarded a contract to provide tumor types to the NCI for the Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of clear cell renal carcinoma tissues (193 cases). These cases are all primary and u Health and Human Services, Department of / National Institutes of Health 6/21/2010
MICHIGAN STATE UNIVERSITY $32,680 Grant Trans-NIH Recovery Act Research Support: This funding will support a summer research experience for a high school biology teacher on another ARRA-funded research project (see http://stimulusfunding.msu.edu/approved-grants/detail.asp?SearchTerm=atchison&EntryID=4&RecPos=1 ). The project, explor Health and Human Services, Department of / National Institutes of Health 5/28/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $2,113,918 Grant Trans-NIH Recovery Act Research Support: Effective prevention strategies for HIV are critically needed, and an effective HIV vaccine is the best long-range hope to dramatically reduce the rate of new HIV infections. To this goal, our current understanding of the biology and epidemiology of HIV t Health and Human Services, Department of / National Institutes of Health 5/03/2010
FRED HUTCHINSON CANCER RESEARCH CENTER $335,371 Grant Trans-NIH Recovery Act Research Support: The Proteomics Shared Resource of the Fred Hutchinson Cancer Research Center will be utilizing funds awarded to purchase a triple quadrupole mass spectrometer to support NIH-funded projects led by principal investigators at the Fred Hutchinson Cancer Rese Health and Human Services, Department of / National Institutes of Health 5/06/2010
UNIVERSITY OF WISCONSIN SYSTEM $99,970 Grant Trans-NIH Recovery Act Research Support: Phosphoinositide signaling regulates all eukaryotic cells. In the phosphoinositide cycle, phosphatidylinositol (PI) is sequentially phosphorylated on the fourth and fifth hydroxyl of the myo-inositol ring by PI kinases and then phosphatidylinositol-phosp Health and Human Services, Department of / National Institutes of Health 5/05/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $500,000 Grant Trans-NIH Recovery Act Research Support: The objective of this proposal is to provide a critical system upgrade for the 7T whole body MR scanner at UCSF. Projects that will benefit from the upgrade include translational research programs in cancer, neurological and musculoskeletal diseases. Health and Human Services, Department of / National Institutes of Health 6/10/2010
MACROGENICS, INC. $2,999,972 Grant Trans-NIH Recovery Act Research Support: The product under consideration, a molecule called CD32BxCD79B, represents a novel approach to countering the function of cells of the immune system that are responsible for autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythemato Health and Human Services, Department of / National Institutes of Health 6/07/2010
WYLE INFORMATION SYSTEMS, LLC $146,445 Contract : Provide support for the OPERA Interface with GM Module that will significantly improve the quality and accuracy of awards, reduce the number of revised awards currently needed when errors are noted, and significantly reduce the administrative burden for b Health and Human Services, Department of / National Institutes of Health 9/26/2009
UNIVERSITY OF ROCHESTER $40,926 Grant Trans-NIH Recovery Act Research Support: Nasonia is a genus of four insect species that is quickly emerging as a model system, particularly for the genetics of complex traits, development, and microbial-host interactions. It has several features that make it an excellent genetic system. These in Health and Human Services, Department of / National Institutes of Health 6/18/2010
UNIVERSITY OF WASHINGTON $214,157 Grant Trans-NIH Recovery Act Research Support: Chromosomes are organized and separated during cell division by a microtubule-based molecular machine,the mitotic spindle. Our overall goal is to reconstitute spindle functions using pure components and apply new tools for manipulating and tracking single Health and Human Services, Department of / National Institutes of Health 5/06/2010
UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON $435,992 Grant Trans-NIH Recovery Act Research Support: Recent advances in biology and medicine continuously bring new opportunities to basic, translational, and clinical research. New instrumentation and computational tools such as mass spectrometry are drivers behind these advances by delivering novel approa Health and Human Services, Department of / National Institutes of Health 4/15/2010
UNIVERSITY OF MASSACHUSETTS $463,569 Grant Trans-NIH Recovery Act Research Support: TDP-43 is a major pathological protein in amyotrophic lateral sclerosis (ALS) and some forms of frontotemporal dementia (FTD) and is also present in ubiquitinated inclusions seen in other neurodegenerative diseases. How TDP-43 contributes to age-dependent Health and Human Services, Department of / National Institutes of Health 6/24/2010
MICROBRIGHTFIELD INC $99,655 Contract : Stereology system for neuroscience research, design based stereology, image analysis and 2D anatomical mapping. This includes the following associated hardware: microscope, computer, microscope isolation platform, digital video camera, focus measurement Health and Human Services, Department of / National Institutes of Health 6/10/2010
GEORGETOWN UNIVERSITY (THE) $687,684 Grant Trans-NIH Recovery Act Research Support: This project examines the cellular mechanisms that promote initiation of DNA synthesis li DNA recombination. Such processes playa vital role in genetic exchange, double-strand break repair, and restart of replication forks. Bacteriophage Mu replicates its Health and Human Services, Department of / National Institutes of Health 6/28/2010
SCIENCE APPLICATIONS INTERNATIONAL CORPORATION $3,552,019 Contract : Provide software development and support services to the NIH Office of Extramural Research (OER) for the Electronic Research Administration (eRA) systems and databases related eight specific projects: 1. Evergreening; 2. Archive/Purge Records; 3. Web Fr Health and Human Services, Department of / National Institutes of Health 5/12/2010
UNIVERSITY OF OKLAHOMA $363,563 Grant Trans-NIH Recovery Act Research Support: The Southern Plains (Oklahoma, Texas, and Kansas) Native Americans (NAs) have excessive cancer incidence and mortality rates. Despite the implementation of educational strategies that have successfully reached many racial/ethnic groups in the United State Health and Human Services, Department of / National Institutes of Health 4/19/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $411,230 Grant Trans-NIH Recovery Act Research Support: The CALGB is comprised of 26 academic medical centers and over 200 affiliated community hospitals joined in the pursuit of improved cancer treatment and better understanding of tumor biology and cancer treatment outcomes via the conduct of controlled clin Health and Human Services, Department of / National Institutes of Health 5/17/2010
UNIVERSITY OF CALIFORNIA, DAVIS $342,293 Grant Trans-NIH Recovery Act Research Support: The purpose of this project is to operate the Curation Division at the Mutant Mouse Regional Resource Center (MMRRC) at the University of California Davis (UCD) in order to advance translational (T1 & T2) research, thus accelerating the availability of va Health and Human Services, Department of / National Institutes of Health 5/13/2010
CASE WESTERN RESERVE UNIVERSITY $121,129 Grant Trans-NIH Recovery Act Research Support: Title: Blood and Mucosal HIV-spcific CD8+ T Cell Responses in High-Risk Seronegatives The mechanisms responsible for the apparent resistance of certain persons to HIV infection despite re Health and Human Services, Department of / National Institutes of Health 6/28/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $61,195 Grant Trans-NIH Recovery Act Research Support: An Administrative Supplement is requested to purchase a fast protein liquid chromatography (FPLC) system for purification of the Gal/GalNAc lectin of Entamoeba histolytica. The purified Gal/GalNAc lectin produced by this FPLC system will be used in the v Health and Human Services, Department of / National Institutes of Health 5/17/2010
L A BRUELL, INC. $200,000 Grant Trans-NIH Recovery Act Research Support: During Phase 1 of Stop, Look and Listen: Separating Fact from Fiction in Evaluating Cases of Child Abuse: An Interactive Learning Tool for Pediatricians, L.A. Bruell, Inc., in collaboration with Mount Sinai School of Medicine and Maimonides Medical Center Health and Human Services, Department of / National Institutes of Health 4/15/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $604,057 Grant Trans-NIH Recovery Act Research Support: The UCSF DERC provides the infrastructure, core laboratories, pilot and feasibility grants, and enrichment programs that advance the study and treatment of Type1 and Type 2 diabetes. The additional PF support and instrumentation will accentuate the miss Health and Human Services, Department of / National Institutes of Health 5/11/2010
UNIVERSITY OF MASSACHUSETTS $993,864 Grant Trans-NIH Recovery Act Research Support: Architectural Epigenetics of Embryonic and Induced Pluripotent Stem Cells: This application addresses broad Challenge Area (14) Stem Cells, and the specific Challenge topic, 14-AG-104: Delineate factors that control the differentiation of pluripotent ste Health and Human Services, Department of / National Institutes of Health 4/30/2010
UNIVERSITY OF MASSACHUSETTS $411,146 Grant Trans-NIH Recovery Act Research Support: CD4 Effector Contraction in Influenza Protective immunity depends on memory CD4 T cells generated during initial Health and Human Services, Department of / National Institutes of Health 5/10/2010
NORTH DAKOTA STATE UNIVERSITY $53,200 Grant Trans-NIH Recovery Act Research Support: The focus of this proposal is to investigate the molecular mechanisms governing Ikaros-mediated transcriptional regulation of vasoactive intestinal peptide receptor - 1 (VPACR-1) in T lymphocytes. Ikaros is a master regulator of lymphopoiesis and sets the Health and Human Services, Department of / National Institutes of Health 4/01/2010
UNIVERSITY OF MARYLAND $139,300 Grant Trans-NIH Recovery Act Research Support: Sexually transmitted diseases (STDs) are among the most common infectious diseases in humans. Local immune responses, especially the mucosal immunoglobulins (Igs), provide the first line of defense against primary mucosal infections. IgG is a dominant Ig Health and Human Services, Department of / National Institutes of Health 6/21/2010
WAKE FOREST UNIVERSITY $208,705 Grant Trans-NIH Recovery Act Research Support: We are applying for funds to replace the ThermoFisher single quadrupole Trace MS GC mass spectrometer that was installed in 1999 and that is used to quantify small volatile lipids. In the last year about 47% of all analyses were performed on the Trace MS. Health and Human Services, Department of / National Institutes of Health 4/22/2010
MAGEE-WOMENS HEALTH CORPORATION $11,139 Grant Trans-NIH Recovery Act Research Support: This Program Project addresses among the most important questions in stem cell medicine and biology through responsible studies on the potentials of pluripotent stem cells from humans (hESC) and nonhuman primates (nhpESC) during development in vitro and i Health and Human Services, Department of / National Institutes of Health 5/10/2010
UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. $285,000 Grant Trans-NIH Recovery Act Research Support: The objective of this grant application is to validate new drug target for pancreatic cancer treatment and/or prevention. Recent studies have demonstrated that STAT3 is constitutively active in several cancers, and downregulation of STAT3 can sensitize c Health and Human Services, Department of / National Institutes of Health 4/21/2010
NORTH CAROLINA STATE UNIVERSITY $12,549 Grant Trans-NIH Recovery Act Research Support: This supplement is requested to provide support for summer student working on a project related to the parent grant ES012473. The summer student will provide a thorough evaluation of the role of C/EBPalpha in UVB-induced DNA damage response involving the Health and Human Services, Department of / National Institutes of Health 5/28/2010
JOHNS HOPKINS UNIVERSITY, THE $122,456 Grant Trans-NIH Recovery Act Research Support: The Study to Help the AIDS Research Effort (SHARE) was funded by NIAID and NCI in 1983 to study the natural history of infection with human immunodeficiency virus, type 1 (HIV). SHARE, along with similar sites in Chicago, Pittsburgh, and Los Angeles, form Health and Human Services, Department of / National Institutes of Health 6/21/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $165,554 Grant Trans-NIH Recovery Act Research Support: Mitogen activated protein kinases (MAPKs) are serine/threonine kinases that mediate signal transduction and orchestrate cellular responses to environmental stress. In mammalian cells, three principle MARK pathways have been identified, including extracell Health and Human Services, Department of / National Institutes of Health 6/28/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $387,742 Grant Trans-NIH Recovery Act Research Support: We plan to purchase a two photon mating system that is specialized for microendoscopy. The gradient refractive index (GRIN) lens microendoscope allows for imaging of previously inaccessible tissue. For our research core, this means imaging the cochlea, th Health and Human Services, Department of / National Institutes of Health 6/03/2010
OREGON HEALTH & SCIENCE UNIVERSITY $385,000 Grant Trans-NIH Recovery Act Research Support: This revised proposal is in response to the opportunity for Enabling RPGs to Leverage NCRR Center and Center-like Programs with the purpose of accelerating the pace of research of our NCI-funded project R01-CA98577-06, 'Mechanisms of Cancer Initiation by Health and Human Services, Department of / National Institutes of Health 6/14/2010
UNIVERSITY OF CALIFORNIA, DAVIS $181,500 Grant Trans-NIH Recovery Act Research Support: The California National Primate Research Center (CNPRC) Is one of eight National Primate Research Centers (NPRCs) funded by the National Institutes of Health, National Center for Research Resource. This renewal application seeks support for Administrative Health and Human Services, Department of / National Institutes of Health 8/06/2010
UNIVERSITY OF ROCHESTER $421,578 Grant Trans-NIH Recovery Act Research Support: In collaboration with members of the national Biostatistics, Epidemiology, Research Design (BERD) Online Resources and Education task force, we have subsequently made significant progress addressing the defined specific aims and fostering collaboration wi Health and Human Services, Department of / National Institutes of Health 9/09/2010
SOCIAL & SCIENTIFIC SYSTEMS, INC. $1,204,584 Grant Trans-NIH Recovery Act Research Support: This award is an administrative supplement for the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Group, specifically to provide supplemental funding for the Immune Activation Project; HIV-1 Project, P1032 and Ancestry Markers Health and Human Services, Department of / National Institutes of Health 9/15/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $103,844 Grant Trans-NIH Recovery Act Research Support: Gonadotropin-releasing hormone (GnRH) is a neurohomrone responsible for the activation and maintenance of reproduction. Neurons that synthesize GnRH must undergo complex maturational processes during development to become a functional system capable of s Health and Human Services, Department of / National Institutes of Health 8/18/2010
TRUSTEES OF TUFTS COLLEGE INC $525,036 Grant Trans-NIH Recovery Act Research Support: This proposal for a Seeding proposal for Collaborative Interdisciplinary Research Program in Diabetes, Endocrinology and Metabolic Diseases will focus on sex differences in obesity and fat distribution and their impact on risk for T2D. Premenopausal wom Health and Human Services, Department of / National Institutes of Health 7/15/2010
FEMCO, INC. $11,404,185 Contract : Roofing Replacement at the National Institutes of Health Bethesda and Poolesville Maryland Campuses. Health and Human Services, Department of / National Institutes of Health 9/28/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $67,527 Grant Trans-NIH Recovery Act Research Support: The specific aims of this project are 1) to determine the mechanisms of action and role in virulence of the Sat cytotoxin secreted by uropathogenic E. coli; and 2) to determine the contribution to virulence in the urinary tract of invertible element-media Health and Human Services, Department of / National Institutes of Health 8/09/2010
RESEARCH FOUNDATION FOR MENTAL HYGIENE INC $374,760 Grant Trans-NIH Recovery Act Research Support: To support research and other projects that will support fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments while also providing economic stimulus to the nation. Health and Human Services, Department of / National Institutes of Health 6/01/2009
DELOITTE CONSULTING LLP $450,000 Contract : The Purpose of this award is to acquire professional Information Technology (IT) support services for the nVision and NIH DATA WAREHOUSE APPLICATION DEVELOPMENT AND OPERATIONS FOR NIH INFORMATION ENTERPRISE SYSTEMS project using the American Recovery and Health and Human Services, Department of / National Institutes of Health 5/28/2010
UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. $4,657,861 Grant Trans-NIH Recovery Act Research Support: The University of Kansas Lawrence campus requests funding to renovate and expand 3646 gross square feet (gsf) in Nichols Hall designated as the Bioinformatics Computing Facility core (BCF). The renovated space will support computationally intensive multid Health and Human Services, Department of / National Institutes of Health 4/29/2010
WESTERN WASHINGTON UNIVERSITY $371,856 Grant Trans-NIH Recovery Act Research Support: The synthetic versality of the C-B bond has let to its use in the synthesis of countless natural products and pharmaceuticaltargets. New methods to incorporate boron substituents into organic substrates would increase the types of molecules that could be Health and Human Services, Department of / National Institutes of Health 6/25/2010
INVIA LLC $194,789 Grant Trans-NIH Recovery Act Research Support: The project title is Quantitative Molecular Imaging of Heart Failure by 123I-MIBG SPECT. Imaging of biologically targeted markers is gaining increased attention for its potential to provide early disease detection, improved individualized risk stratificat Health and Human Services, Department of / National Institutes of Health 4/19/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $32,797 Grant Trans-NIH Recovery Act Research Support: Human APOBEC3G is capable of altering the HIV genome by deaminating cDNA cytosines to uracils. This activity can genetically inactivate HIV. As a counter-defense mechanism, HIV promotes protein degradation of APOBEC3G. Degradation requires that the HIV vi Health and Human Services, Department of / National Institutes of Health 6/01/2010
CHILDRENS HOSPITAL OF PHILADELPHIA $70,600 Grant Trans-NIH Recovery Act Research Support: Chronic kidney disease (CKD) and its metabolic derangements substantially affect the well-being of children. In order to define the nature, magnitude, and temporal evolution of the adverse effects of progressive CKD, we propose to extend the follow-up of Health and Human Services, Department of / National Institutes of Health 6/23/2010
LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY $84,913 Grant Trans-NIH Recovery Act Research Support: This project concerns the death of cells through the process called ?apoptosis?, which is critical both for normal physiology and development. Apoptosis is also important for the origin and treatment of various diseases, including cancer, AIDS, and disord Health and Human Services, Department of / National Institutes of Health 6/11/2010
NORTHWESTERN UNIVERSITY $5,984,977 Grant Trans-NIH Recovery Act Research Support: Gene map of the HLA class I supercluster: Genome-wide association studies (GWASs) are used to map regions of the human genome that contribute to disease, but such analyses do not identify the specific causative gene and genetic variant. Although the patte Health and Human Services, Department of / National Institutes of Health 9/20/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $373,073 Contract : RECOVERY: Computational Thinking to Support Clinicians and Biomedical Scientists Health and Human Services, Department of / National Institutes of Health 9/22/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $171,100 Grant Trans-NIH Recovery Act Research Support: Hormone-refractory tumors are the most deadly form of prostate cancer. There is currently no cure for patients with these very aggressive and highly metastatic tumors. Thus, the design of effective therapies for patients with such advanced prostate cancer Health and Human Services, Department of / National Institutes of Health 9/25/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $27,925 Grant Trans-NIH Recovery Act Research Support: SUMMARY: Ionizing Radiation (IR) induces p53-dependent and p53-independent apoptosis. Understanding p53-dependent apoptosis has benefited immensely from studies in mammalian cells that identified biochemical activities and genetic analysis in model organi Health and Human Services, Department of / National Institutes of Health 8/13/2010
UNIVERSITY OF IDAHO $839,961 Grant Trans-NIH Recovery Act Research Support: The transition from adolescence to adulthood is a challenging time in diabetes self-management. As they move towards independence, young-adults with diabetes have diminishing support from families and health care providers, while simultaneously coping wit Health and Human Services, Department of / National Institutes of Health 8/15/2010
UNIVERSITY OF WISCONSIN SYSTEM $80,367 Grant Trans-NIH Recovery Act Research Support: Cystic fibrosis (CF) is the most common life-threatening genetic disorder with an incidence of ~1:3400 in Caucasians. Although CF begins in early infancy, delayed diagnosis is common and often leads to severe, potentially irreversible malnutrition. Obstr Health and Human Services, Department of / National Institutes of Health 4/26/2010
LOMA LINDA UNIVERSITY $500,000 Grant Trans-NIH Recovery Act Research Support: This application requests funding for a state-of-the-art shared mass spectrometer that will provide collaborative research for the Loma Linda University mass spectrometry facility. The LTQ-Orbitrap-XL-ETD mass spectrometer is manufactured by Thermo Fisher Health and Human Services, Department of / National Institutes of Health 4/22/2010
COLD SPRING HARBOR LABORATORY ASSOCIATION, INC. $851,656 Grant Trans-NIH Recovery Act Research Support: This application is a request for an LTQ-Orbitrap Velos ETD mass spectrometer to support new proteomics research efforts at Cold Spring Harbor Laboratory (CSHL). The instrument will be used to support multiple CSHL investigators in studies including phosp Health and Human Services, Department of / National Institutes of Health 5/13/2010
UNIVERSITY OF TEXAS AT DALLAS $174,188 Grant Trans-NIH Recovery Act Research Support: Cortical processing of sensory information plays a critical role in sensory discrimination, object recognition and memory. Cortical sensory processing has been shown to be highly dynamic, with past experience, current context and expectations shaping how Health and Human Services, Department of / National Institutes of Health 5/12/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $418,000 Grant Trans-NIH Recovery Act Research Support: The goal of the proposed study is to identify renal microRNAs and their target genes that could potentially contribute to the development of salt-induced hypertension and renal injury in the Dahl salt-sensitive (SS) rat. The SS rat is a widely used anima Health and Human Services, Department of / National Institutes of Health 5/29/2009
WASHINGTON UNIVERSITY, THE $99,641 Grant Trans-NIH Recovery Act Research Support: This ARRA administrative supplement will set up analysis pipelines for cutting-edge neuroimaging analyses, improve recruitment speed and efficiency, and improve the security and reliability of data by creating computerized versions of paper-based tasks an Health and Human Services, Department of / National Institutes of Health 4/08/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $33,313 Contract : We have/are in the process of completed(ing) the Material transfer Agreement and Data Use Agreement with the TCGA Biospecimen Core Resources. Moreover, we have received (submitted for) Institutional Review Board approval for participation in TCGA. Durin Health and Human Services, Department of / National Institutes of Health 4/21/2010
UNIVERSITY OF NEBRASKA $11,800 Grant Trans-NIH Recovery Act Research Support: The proposed research addresses a fundamental question in biology: how do the environment and genotype interact to produce the phenotype? The pea aphid, an emerging genomic model system, exhibits dramatically different adult phenotypes of winged or unwing Health and Human Services, Department of / National Institutes of Health 5/21/2010
THE GEORGE WASHINGTON UNIVERSITY $1,102,576 Grant Trans-NIH Recovery Act Research Support: OVERALL PURPOSE: TODAY is a collaborative group funded by the National Instituate of Diabetes and Digestive and Kidney Diseases (NIDDK) to conduct +B20t a clinical trial of therapies in children with type 2 diabetes (T2D). The TODAY study has enrolled 70 Health and Human Services, Department of / National Institutes of Health 4/12/2010
LOGICAL TECHNICAL SERVICES CORP. $219,341 Contract : Due to the critical public need for H1N1 therapies, vaccines, and diagnostics, four projects have been initiated within NIAID to combat this disease. Each project is based on a 24-month delivery schedule to provide a series of results within this period Health and Human Services, Department of / National Institutes of Health 5/07/2010
FISHER SCIENTIFIC COMPANY L.L.C. $9,636 Contract : Laboratory Equipment and Supplies. Health and Human Services, Department of / National Institutes of Health 5/17/2010
FISHER SCIENTIFIC COMPANY L.L.C. $8,637 Contract : Laboratory Equipment and Supplies. Health and Human Services, Department of / National Institutes of Health 12/07/2009
SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH $203,550 Grant Trans-NIH Recovery Act Research Support: This award is for bridge funding that will be used to generate new data. There are three main issues which will be addressed and are as follows: 1) support for the neurotrophin hypothesis, 2) feasibility of Brain Derived Neurotrophic Factor (BDNF) measure Health and Human Services, Department of / National Institutes of Health 6/15/2010
GLOBAL CONSULTING INC. $497,000 Contract : Technical industrial hygiene support to the National Institutes of Health, Divison of Health and Safety. Industrial hygiene services shall include, but not be limited to asbestos assessment surveys, asbestos abatement monitoring, indoor air quality studie Health and Human Services, Department of / National Institutes of Health 3/30/2010
UNIVERSITY OF ARIZONA $33,502 Grant Trans-NIH Recovery Act Research Support: Cognitive and memory loss disorders affect a large part of the US population, and as life expectancy of humans continues to increase, the occurrence of late onset disorders leading to behavioral deficits and memory loss is on the rise. The molecular basis Health and Human Services, Department of / National Institutes of Health 9/30/2010
RUSH UNIVERSITY MEDICAL CENTER $62,811 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to determine the mechanism of how HIV induces the non-classical major histocompatiblity complex class I molecule, HLA-G and how HLA-G may prevent natural killer cells from killing HIV-infected cells. Health and Human Services, Department of / National Institutes of Health 9/20/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $279,698 Grant Trans-NIH Recovery Act Research Support: The QP Expression is a robotic colony picking and library management system that allows automated manipulation of bacterial or yeast clones, and RNAi libraries. The attributes of this system include software and programming capabilities involved in the ge Health and Human Services, Department of / National Institutes of Health 7/15/2010
GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. $235,193 Grant Trans-NIH Recovery Act Research Support: This study will determine whether exercise training influences cognition in overweight children when compared to an attention control condition. This area of research is particularly important due to the increasing rate of overweight and its sequelae amon Health and Human Services, Department of / National Institutes of Health 9/24/2010
OKLAHOMA STATE UNIVERSITY $339,567 Grant Trans-NIH Recovery Act Research Support: The quality of the maternal and developmental environments have been demonstrated to impact a number of traits in adult humans and other animals, including likelihood of developing coronary heart disease, type 2 diabetes mellitus, and hypertension; perfor Health and Human Services, Department of / National Institutes of Health 9/01/2010
LUNA INNOVATIONS INCORPORATED $117,974 Grant Trans-NIH Recovery Act Research Support: Leptospirosis, an infection resulting from skin or mucous membrane contact with urine of infected animals, is considered the most common zoonosis worldwide. It is estimated to affect tens of millions annually with mortality rates ranging from 5 to 25%. Le Health and Human Services, Department of / National Institutes of Health 8/02/2010
UNIVERSITY OF ILLINOIS $98,671 Grant Trans-NIH Recovery Act Research Support: This award is to be used improve both events ascertainment collection and retention effors for the Hispanic Chronic Renal Insufficiency Cohort (HCRIC) Study. The HCRIC Study is based at the University of Illinois at Chicago (UIC) and is a R01 funded anci Health and Human Services, Department of / National Institutes of Health 9/28/2009
PENNSYLVANIA STATE UNIVERSITY, THE $1,613,425 Grant Trans-NIH Recovery Act Research Support: This proposal describes a request for funds to purchase a newly developed secondary ion mass spectrometer for 3-dimensional chemical imaging of biological cells and tissue. The instrument is based upon the use of a micro-focused ion beam consisting of ene Health and Human Services, Department of / National Institutes of Health 5/13/2010
PENNSYLVANIA STATE UNIVERSITY, THE $69,684 Grant Trans-NIH Recovery Act Research Support: Herpesviruses are ubiquitous and are responsible for many important human diseases. Perhaps the least understood steps in their replication are the cytoplasmic events of budding and egress, which we are investigating with the most thoroughly characterized Health and Human Services, Department of / National Institutes of Health 3/31/2010
FISHER SCIENTIFIC COMPANY L.L.C. $75,849 Contract : Laboratory Equipment and supplies Health and Human Services, Department of / National Institutes of Health 5/17/2010
PENNSYLVANIA STATE UNIVERSITY, THE $499,800 Grant Trans-NIH Recovery Act Research Support: The Illumina Genome Analyzer IIx will add a needed capability to the core sequencing facility of Penn State's Center for Gene Regulation and Center for Comparative Genomics and Bioinformatics. Our current genomics research with the help of next-generation Health and Human Services, Department of / National Institutes of Health 5/06/2010
PENNSYLVANIA STATE UNIVERSITY, THE $29,923 Grant Trans-NIH Recovery Act Research Support: The goal of this proposal is to determine the X-ray crystal structures of archaeal RNA polymerase and its complexes with auxiliary protein factors and nucleic acid. The transcription apparatus in Archaea can be described as a simplified version of its euk Health and Human Services, Department of / National Institutes of Health 6/18/2010
VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY $1,573,442 Grant Trans-NIH Recovery Act Research Support: Models of infectious disease can inform public health policy decisions. The long-term goal of this research is to create network-based models of disease that become useful tools for public health policy-makers. To this end, we propose research tasks in th Health and Human Services, Department of / National Institutes of Health 8/11/2009
INDIVUMED INC. $38,000 Contract : Indivumed has been awarded a contract to provide tumor types to the NCI for the Cancer Genome Atlas project. Specifically this award is to fund the provision of 50 colon cancer cases. These are predominantly retrospective specimens. These cases are all Health and Human Services, Department of / National Institutes of Health 2/16/2010
TRUSTEES OF PRINCETON UNIVERSITY, THE $500,000 Grant Trans-NIH Recovery Act Research Support: This application requests funds to purchase a Prairie Instruments Ultima multiphoton microscope system. This new instrument will greatly extend the current capabilities for fluorescence microscopy at Princeton University. The Prairie system will allow res Health and Human Services, Department of / National Institutes of Health 6/10/2010
TRUSTEES OF PRINCETON UNIVERSITY, THE $706,300 Grant Trans-NIH Recovery Act Research Support: The overarching goal of the proposed Center for Quantitative Biology remains to instantiate at Princeton a research and teaching environment that fully meets the challenge and opportunity, presented by advances in computation and genomics, to practice a u Health and Human Services, Department of / National Institutes of Health 4/16/2010
LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY $146,350 Grant Trans-NIH Recovery Act Research Support: This supplement awarded under the American Recovery and Reinvestment Act will fund the purchase of an ECL imager to carry out all the western blotting required in this project. It will also allow for a postdoctoral fellow to remain supplied and funded on Health and Human Services, Department of / National Institutes of Health 6/28/2010
UNIVERSITY OF PITTSBURGH THE $123,008 Contract : The University of Pittsburgh has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of Endometrial carcinoma (70 cases), Hepatocellular carcinoma (20 case Health and Human Services, Department of / National Institutes of Health 5/04/2010
UNIVERSITY OF PITTSBURGH THE $330,511 Contract : The University of Pittsburgh has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of renal clear cell tissues (200 additional cases) under delivery orde Health and Human Services, Department of / National Institutes of Health 5/12/2010
UNIVERSITY OF PITTSBURGH THE $565,187 Contract : The University of Pittsburgh has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of Lung squamous cell carcinoma (50 cases), Lung adenocarcinoma (30 ca Health and Human Services, Department of / National Institutes of Health 3/22/2010
HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY M $45,882 Grant Trans-NIH Recovery Act Research Support: Recent data suggest that hormone replacement therapy (HRT)can worsen risk for stroke, but the potential benefits of HRT on brain rescue once a cerebral ischemic event occurs have been poorly studied. Emerging hypotheses suggest that timing at which HRT is Health and Human Services, Department of / National Institutes of Health 5/20/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $1,040,868 Grant Trans-NIH Recovery Act Research Support: This should be material from previous submissions. Not for sure why last quarter info was showing here. Please populate with material from initial ARRA submission. Health and Human Services, Department of / National Institutes of Health 6/16/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $111,000 Grant Trans-NIH Recovery Act Research Support: Biological properties of HIV-1 V3 evolutionary variants- Analysis of the genetic complexity of the HIV-1 population during acute infection has important implications to prevention and therapeutic strategies. In this application for an ARRA supplement, we Health and Human Services, Department of / National Institutes of Health 6/01/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $13,300 Contract : The University of North Carolina has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of breast, lung, colon, head and neck, hepatocellular, kidney, bl Health and Human Services, Department of / National Institutes of Health 1/26/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $355,171 Grant Trans-NIH Recovery Act Research Support: ROLE OF YAPS IN Y. PESTIS PATHOGENESIS Background and Aims Yersinia pestis (Yp) is a Gram-negative bacterial human pathogen that is the causative agent of bubonic, pneumonic and septicemic plague. No vaccine is currently available for either form of plag Health and Human Services, Department of / National Institutes of Health 6/14/2010
JS TECHNOLOGY, INC $66,000 Contract : Additional administrative support to increase compliance oversight activities resulting from the influx of ARRA grants. Health and Human Services, Department of / National Institutes of Health 4/15/2010
NORTHSHORE UNIVERSITY HEALTHSYSTEM RESEARCH INSTITUTE $99,125 Grant Trans-NIH Recovery Act Research Support: Necrotizing enterocolitis is a common and devastating intestinal emergency that primarily affects premature infants, whose etiology, pathogenesis, and treatment strategies remain poorly understood. Findings in our lab and others has identified an importa Health and Human Services, Department of / National Institutes of Health 7/27/2010
POMONA COLLEGE $440,159 Grant Trans-NIH Recovery Act Research Support: In humans, hair cells are the receptors found within the inner ear that mediate hearing and balance. When the sensory hair cells die through environmental stresses (e.g. listening to the iPod too loudly for too long), normal aging and genetics, this often Health and Human Services, Department of / National Institutes of Health 4/09/2010