Primary Recipient

TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Amount

$270,051.00

Award Date

9/30/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

Determination of a high resolution structure of the InsP3R C tail in complex with Bcl xL will provide a basis for understanding how binding of Bcl xL affects channel Ca2+ signaling functions, with relevance for cell death mechanisms in cancer and neurodeg