Primary Recipient

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Amount

$307,209.00

Award Date

9/25/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

In research studies supported by this grant, we discovered mutations in a gene called PTPN11 in pediatric and adult leukemia, which makes a protein called SHP-2. These abnormal SHP-2 proteins cause leukemia and cause developmental disorders by turning on