Primary Recipient

BOSTON BIOMEDICAL RESEARCH INSTITUTE, INC.

Amount

$1,153,892.00

Award Date

8/14/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

The overall purpose of this award is to determine the role of Mdm2 and its homolog Mdm4 in maladaptive cardiac hypertrophy and the associated apoptosis. Mdm2 is an E3 ubiquitin ligase, which promotes the proteasome-mediated degradation of the tumor suppr