Primary Recipient

TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Amount

$639,666.00

Award Date

6/04/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

In this proposal we will characterize a novel signaling pathway activated by the growth factor heregulin (HRG) that involves the small G protein Rac1 and its activator P Rex1. Rac1 and P Rex1 mediate mitogenic and motile signals induced by HRG. The goal i