Primary Recipient

SEATTLE CHILDREN'S HOSPITAL

Amount

$178,891.00

Award Date

9/22/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

STAT3 Functional Defects and a Novel Therapeutic Approach for Hyper IgE Syndrome -- Autosomal Dominant Hyper IgE Syndrome (AD-HIES) is caused by heterozygous hypomorphic mutations of the transcription regulator STAT3. Characteristically, these mutations o