Primary Recipient

REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE

Amount

$141,598.00

Award Date

12/25/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

Mammalian cells have evolved sophisticated DNA repair systems to correct mispaired or damaged bases and extrahelical loops. However, at hairpin-structure forming CAG repeats, the MSH2/MSH3 protein causes rather than corrects mutation, resulting in CAG ex