Primary Recipient

UNIVERSITY OF IOWA, THE

Amount

$98,028.00

Award Date

2/17/2010

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

We have discovered 2 ubiquitin sorting receptors (Ub-sorting receptors) that sort ubiquitinated membrane proteins (Ub-cargo) for degradation in the lysosome. One is the GGA coat protein, which appears to bind Ubcargo at the TGN and incorporate it into ves