Primary Recipient

PACIFIC NORTHWEST RESEARCH INSTITUTE

Amount

$82,075.00

Award Date

12/30/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

C57BLKS/J mice overexpressing the antioxidant enzyme glutathione peroxidase-1 (GPx-1) specifically in pancreatic beta-cells were generated. The GPx-1 transgene was introgressed into the beta-cells of db/db mice. The onset of hyperglycemia in db/db-GPx(+