Primary Recipient

THOMAS JEFFERSON UNIVERSITY

Amount

$772,500.00

Award Date

6/01/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

?1-adrenergic receptors (?1ARs) generally do not couple to the adenylyl cyclase inhibitory heterotrimeric G protein, Gi, however, data in cultured cells indicate that phosphorylation of ?1ARs by GRK5 can allow for Gi-coupling due to GRK5 actions causing a