Primary Recipient

MEDICAL COLLEGE OF WISCONSIN, INC., THE

Amount

$217,161.00

Award Date

7/16/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

GTP cyclohydrolase I (GCH-1) is the rate-limiting enzyme in the biosynthesis of BH4, an essential cofactor for endothelial nitric oxide synthase (NOS3). BH4 depletion uncouples NOS activity, which is characterized by superoxide anion generation rather tha