Primary Recipient

REGENTS OF THE UNIVERSITY OF MICHIGAN

Amount

$386,250.00

Award Date

6/21/2010

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

We have performed additional studies to understand the activation of the NLRP3 inflammasome. We found that al stimuli tested including ATP, bacterial toxins, and particulate matter (silica) induce K+ efflux. The new studies have revealed that K+ efflux is