Primary Recipient

UNIVERSITY OF ALABAMA AT BIRMINGHAM

Amount

$471,383.81

Award Date

6/17/2010

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

LKB1 (liver kinase B1) is a serine/threonine kinase that is mutationally inactivated in Peutz-Jeghers syndrome and many cancers. It is estimated that 93% of PJS patients will develop a malignant tumor at an average age of 43 years. LKB1 mutations have als