Primary Recipient

WAYNE STATE UNIVERSITY (INC)

Amount

$909,524.00

Award Date

7/17/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

Aim 1. We will define the structural and biological basis for the shedding of mRANKL by MT1-MMP. - Aim 1.1. Investigate the structural basis of MT1-MMP shedding of mRANKL; - Aim 1.2. Identify MT1-MMP/mRANKL complexes at the surface of pc cells. Aim 2. We