Primary Recipient

UNIVERSITY OF PITTSBURGH THE

Amount

$441,615.00

Award Date

7/17/2009

Administering Agency

Health and Human Services, Department of / National Institutes of Health

CDFA Number

93.701

CDFA Program Title

Trans-NIH Recovery Act Research Support

Description

Aim 1: To test the hypothesis that a-Syn inhibits TH in vivo by effects on PP2A. Our in vitro data suggest that a-Syn inhibits TH and reduces DA synthesis, by increasing PP2A activity. To assess this in vivo, we will use nigral and striatal tissue from