Recovery Tracker

How Much Stimulus Funding is Going to Your County?

Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page

Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.

Recipient Amount Type Description Federal Dept./Agency Date
ILLUMINA, INC. $752,450 Contract : Genetic Analysis Equipment Health and Human Services, Department of / National Institutes of Health 9/24/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $849,841 Grant Trans-NIH Recovery Act Research Support: The long-term goal of this project is to understand the genomic mechanisms that generate phenotypic diversity in vertebrates. Rapid progress in genomics has provided nearly complete sequences for several organisms. Comparative analysis suggests many funda Health and Human Services, Department of / National Institutes of Health 9/16/2010
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. $782,492 Grant Trans-NIH Recovery Act Research Support: Public Health Relevance: Chagas disease (American trypanosomiasis) is the highest impact infectious disease in Latin America and is a growing threat in the United States. The goal of this project is to develop and field test a serodiagnostic test to detec Health and Human Services, Department of / National Institutes of Health 8/02/2010
J.DAVID GLADSTONE INSTITUTES, THE $289,500 Grant Trans-NIH Recovery Act Research Support: Obesity and related diseases, such as diabetes, occur when there is an overload of triglycerides in the fat and other tissues. This grant focuses on studying all aspects of the basic biology of the enzymes (called DGATS) that make triglycerides. Since D Health and Human Services, Department of / National Institutes of Health 9/30/2010
RUSH UNIVERSITY MEDICAL CENTER $279,804 Grant Trans-NIH Recovery Act Research Support: Dr. Mariam Aziz - During the past year, we have continued our studies looking at HIV specific ADCC activity in the genital mucosa women in two unique populations of women; women who seroconverted to HIV and women who are at high risk because they regularl Health and Human Services, Department of / National Institutes of Health 8/23/2010
OREGON HEALTH & SCIENCE UNIVERSITY $255,257 Grant Trans-NIH Recovery Act Research Support: Tuberculosis remains an important clinical problem throughout the world. The causative agent of tuberculosis, Mycobacterium tuberculosis (Mtb), is a facultative intracellular pathogen, residing primarily in macrophages. Protective immunity to tuberculosis Health and Human Services, Department of / National Institutes of Health 8/02/2010
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK $198,581 Grant Trans-NIH Recovery Act Research Support: Myelodysplastic syndromes (MDS) are stem-cell malignancies most frequently seen among elderly patients, resulting in a high annual incidence of approximately 14,000 new cases per year. The incidence of MDS continues to increase as our population ages. Abo Health and Human Services, Department of / National Institutes of Health 8/17/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $112,387 Grant Trans-NIH Recovery Act Research Support: Glaucoma is a leading cause of blindness. Diagnosis and monitoring of glaucoma is of particular importance because the onset is insidious and the visual damage is irreversible. The goal of the Advanced Imaging for Glaucoma (AIG) study (www.AIGStudy.net) i Health and Human Services, Department of / National Institutes of Health 7/26/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $55,288 Grant Trans-NIH Recovery Act Research Support: Campylobacter jejuni is a commensal bacterium of the gastrointestinal tracts of many animals, specifically birds. However, when C. jejuni infects the gastrointestinal tracts of humans, the bacterium often causes a mild to severe, bloody diarrheal syndrome Health and Human Services, Department of / National Institutes of Health 9/20/2010
TRIPLE F FARMS INC $43,332 Contract : ARRA Influenza Project ? Animal Model: Ferrets are required for animal research studies using H1N1 influenza. The deliverables include: 144 female ferrets; ferret serum samples; packaging and shipping of blood samples; filtered shipping crates and air fre Health and Human Services, Department of / National Institutes of Health 9/15/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $1,169,177 Grant Trans-NIH Recovery Act Research Support: The specific aims of the study are: 1. Develop inference methodology, including computational algorithms, for logistic and probit regression for binary outcomes, using the Bayesian nonparametric approach for instrumental variables. 2. Develop inference Health and Human Services, Department of / National Institutes of Health 9/27/2010
MILLIPORE CORPORATION $111,639 Contract : Open Market Supplies Health and Human Services, Department of / National Institutes of Health 9/21/2010
BAYLOR COLLEGE OF MEDICINE $99,859 Grant Trans-NIH Recovery Act Research Support: SUMMARY PURPOSE: Involve middle school teachers in biomedical research that they can translate into lessons for their students. ABSTRACT: The Foundations for Student Success Project (PARENT GRANT) is creating a new curriculum for after school programs to Health and Human Services, Department of / National Institutes of Health 7/06/2010
TRANSCENDENT INTERNATIONAL, LLC $237,399 Grant Trans-NIH Recovery Act Research Support: In the United States, the long-running nursing shortage is a significant problem affecting healthcare delivery. In 2005, approximately 126,000 nursing positions in the U.S. were unfilled. It is forecasted that by 2020, the nursing workforce will experienc Health and Human Services, Department of / National Institutes of Health 9/30/2010
GE HEALTHCARE BIO-SCIENCES CORP. $40,370 Contract : PURCHASE OF: AKTA PURIFIER 10 W/ DESKTOP CONTROL AND ACCESSORIES Health and Human Services, Department of / National Institutes of Health 9/01/2010
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. $497,658 Grant Trans-NIH Recovery Act Research Support: Natural Experiments and RCT Generalizability: The Women's Health Initiative Principal Investigator: Vogt, William B This application addresses Broad Challenge Area (07) Enhancing Clinical Trials and specific challenge topic 07-AG-103 Development of method Health and Human Services, Department of / National Institutes of Health 9/14/2010
FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE $46,062 Grant Trans-NIH Recovery Act Research Support: Despite advances in the management of the septic patient, a large number of such patients die of the ensuing septic shock and multiple organ failure. The high mortality rate may be reduced by modulation of the mediators responsible for progressive cell a Health and Human Services, Department of / National Institutes of Health 8/27/2010
JOHNS HOPKINS UNIVERSITY, THE $641,500 Grant Trans-NIH Recovery Act Research Support: This proposal requested funds for an Ibis T6000 Biosensor System that incorporates broad-range PCR followed by electrospray ionization time-of-flight (ESI-TOF) mass spectrometric analysis to determine the precise base composition of the PCR amplicons. The Health and Human Services, Department of / National Institutes of Health 7/01/2010
BUSINESS INTELLIGENCE, INC. $2,131,440 Contract : NBS PMO Support Services Health and Human Services, Department of / National Institutes of Health 7/14/2010
UNIVERSITY OF CHICAGO, THE $390,000 Grant Trans-NIH Recovery Act Research Support: Staphylococcus aureus is the leading cause of community and nosocomially-acquired infectious and toxin-mediated syndromes, some life-threatening that affect patients of all ages. As a species, S. aureus has become resistant to antibiotics of all classes Health and Human Services, Department of / National Institutes of Health 8/02/2010
CREIGHTON UNIVERSITY $2,715,666 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION: Fumonisin (FB1) is a mycotoxin produced by a common fungal contaminant of corn (maize) . An association has recently been observed between ingestion of FB1-contaminated maize during early pregnancy and increased risk for having a child with a Health and Human Services, Department of / National Institutes of Health 9/24/2010
MAGEE-WOMENS HEALTH CORPORATION $311,334 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The purpose of this proposal is to demonstrate the capabilities of the University of Pittsburgh to participate as a Clinical site in a NICHD-sponsored network addressing Preterm Birth in Nulliparous Women (Nullipara Ne Health and Human Services, Department of / National Institutes of Health 7/08/2010
MISSOURI SYSTEM, UNIVERSITY OF $122,259 Grant Trans-NIH Recovery Act Research Support: This is a revision of a competing continuation / renewal. The period 7/1/2001 - 6/30/2006 continued work funded since 1984. This period resulted in 1 book, 37 journal articles, and 14 book chapters related to working memory and its development in childhoo Health and Human Services, Department of / National Institutes of Health 7/29/2010
OKLAHOMA MEDICAL RESEARCH FOUNDATION $248,365 Grant Trans-NIH Recovery Act Research Support: The overall objective of the funded project Notch-induced protein degradation in lymphopoiesis is to investigate the mechanism by which Notch signaling regulates lymphocyte development and leukemogenesis. Our previous study has shown that Notch signaling Health and Human Services, Department of / National Institutes of Health 7/12/2010
CASE WESTERN RESERVE UNIVERSITY $15,700 Grant Trans-NIH Recovery Act Research Support: This study will define mucosal virulence and mechanism of innate immune host defense against aerosolized Rift Valley fever virus, a Category A biodefense pathogen. Rift Valley Fever virus (RVFV) is designated a priority pathogen based upon its projected s Health and Human Services, Department of / National Institutes of Health 5/24/2010
UNIVERSITY OF TENNESSEE $404,731 Grant Trans-NIH Recovery Act Research Support: This project is to develop a novel and cost effective technology, the Adaptive Photorefraction, to detect and quantify mild or early stage keratoconus (FFKC). FFKC is the major cause of the refractive laser surgery failures in the US. The research team wi Health and Human Services, Department of / National Institutes of Health 8/04/2009
UNIVERSITY OF ILLINOIS $659,510 Grant Trans-NIH Recovery Act Research Support: We propose to apply high throughput genomic technologies to examine the relationship between the vaginal microbial community (microbiome) and two significant problems impacting women?s health, bacterial vaginosis (BV) and preterm birth, the most significa Health and Human Services, Department of / National Institutes of Health 9/07/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $905,298 Grant Trans-NIH Recovery Act Research Support: Translational research is the cornerstone of health care advances. However, facilitating communication between research participants or consumers and investigators has been a challenge for decades. Divergent consumer and investigator perspectives have led Health and Human Services, Department of / National Institutes of Health 7/14/2010
UNIVERSITY OF MIAMI $228,001 Grant Trans-NIH Recovery Act Research Support: Molecular in vivo imaging allows for diagnostic imaging, target screening, and therapeutic monitoring of disease on a molecular level, prior to evidence of anatomical changes that are detected with conventional imaging modalities. We propose to further de Health and Human Services, Department of / National Institutes of Health 8/04/2010
WASHINGTON METROPOLITAN AREA TRANSIT AUTHORITY $275,000 Contract : These ARRA funds provided SmartBenefits on SmarTrip cards to NIH employees that they may use to ride MetroBus or MetroRail. The fare media may also be used on DASH, Ride On, Fairfax Connector, ART, CUE, Loudoun County Transit, Omniride, TheBus, DC Circula Health and Human Services, Department of / National Institutes of Health 7/06/2010
YALE UNIVERSITY $694,899 Grant Trans-NIH Recovery Act Research Support: The conduct of interdisciplinary and translational clinical research is complex and can be optimized through coordination of specialized resources across projects. This P30 will provide core Human Subjects resources for coordinated and efficient data coll Health and Human Services, Department of / National Institutes of Health 8/16/2010
SEATTLE CHILDREN'S HOSPITAL $393,556 Grant Trans-NIH Recovery Act Research Support: Although the specific role(s) for B cells in disease pathogenesis has not been established, B cells are strongly implicated in development of T1D both in animal models and in humans. Consistent with this idea, B cell depletion therapy with rituximab has r Health and Human Services, Department of / National Institutes of Health 9/30/2010
BAYLOR COLLEGE OF MEDICINE $109,002 Grant Trans-NIH Recovery Act Research Support: The purpose of this study is to dissect the role of coactivators in cellular function. Steroid hormones stimulate growth, maturation and the development of new biochemical capacities in their endocrine target organs and are keys to understanding multiple Health and Human Services, Department of / National Institutes of Health 8/04/2010
UNIVERSITY OF WASHINGTON $999,425 Grant Trans-NIH Recovery Act Research Support: To establish a collaborative health research infrastructure that will provide a sustainable foundation for health leaders from Seattle Public Schools and UW Research Centers to work together to formulate pertinent research questions, design and conduct re Health and Human Services, Department of / National Institutes of Health 9/07/2010
RESEARCH TRIANGLE INSTITUTE $58,222 Grant Trans-NIH Recovery Act Research Support: RTI will support Columbia University and Boston University in a collaborative study of the exposure and biological impacts of passive tobacco smoke exposure on adults and potentiall children. This support will come in several forms including: a) building Health and Human Services, Department of / National Institutes of Health 9/02/2010
GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. $156,450 Grant Trans-NIH Recovery Act Research Support: The Animal Models of Diabetic Complications Consortium (AMDCC) and the Mouse Metabolic Phenotyping Centers (MMPC) are two multi-center initiatives funded by the NIH. During the current five year funding cycle, the AMDCC had the primary responsibility of d Health and Human Services, Department of / National Institutes of Health 9/30/2010
SIEMENS MEDICAL SOLUTIONS USA, INC. $1,800,000 Contract : This funding is for the purchase of a Siemens Medical Solutions 7T MRI which provides the potential for microscopic spatial resolution visualizing anatomy previously unseen. In addition, it enables the observation and analysis of tissue metabolism and fun Health and Human Services, Department of / National Institutes of Health 9/30/2009
UNIVERSITY OF TEXAS AT SAN ANTONIO $65,183 Grant Trans-NIH Recovery Act Research Support: Coccidioides is an airborne fungal pathogen that can cause mild to severe respiratory disease (coccidioidomycosis; San Joaquin Valley fever) in immunocompetent individuals. The fungus inhabits desert soil in the Southwestern U.S. between West Texas and So Health and Human Services, Department of / National Institutes of Health 9/07/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $488,105 Grant Trans-NIH Recovery Act Research Support: The goal of this proposal is to examine how inflammation, tissue microenvironment and regulatory T cells influence the development of long term immunity to different kinds of viruses including influenza A virus. We have examined how exposure to prolonged Health and Human Services, Department of / National Institutes of Health 7/06/2010
IOWA STATE UNIVERSITY $100,051 Grant Trans-NIH Recovery Act Research Support: We have developed a model system to determine biologic activity of unit carbohydrates in altering immune responses. This model consists of 1um fluorescent latex beads coated with pathogen cap sugars, specifically M. bovis Mannosylated-Lipoarabinomannan (M Health and Human Services, Department of / National Institutes of Health 8/16/2010
UNIVERSITY OF IOWA, THE $60,000 Grant Trans-NIH Recovery Act Research Support: It has become apparent that RNA polymerase II (RNAPII) elongation control plays a major role in regulating transcription throughout development and differentiation of multi-cellular organisms. The process is characterized by the default action of negative Health and Human Services, Department of / National Institutes of Health 8/13/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $8,068,260 Grant Trans-NIH Recovery Act Research Support: Although many scientific advances in global health have occurred with support from NIH and charitable foundations, often these have stalled in implementation or scalability for the developing world due to lack of affordability, design modeling or business Health and Human Services, Department of / National Institutes of Health 9/13/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $40,810 Grant Trans-NIH Recovery Act Research Support: The overall objective of the parent grant (HD056030) is to understand how disruption of cilia alters the hedgehog signaling pathway and subsequently results in severe birth defects and disease states. The purpose of this supplement was to request funds t Health and Human Services, Department of / National Institutes of Health 7/07/2010
SEATTLE PACIFIC UNIVERSITY $21,600 Grant Trans-NIH Recovery Act Research Support: Brain Activation in Women Treated with Mindfulness-Based Relapse Prevention Health and Human Services, Department of / National Institutes of Health 9/20/2010
TUFTS MEDICAL CENTER PARENT, INC. $90,725 Grant Trans-NIH Recovery Act Research Support: Cryptosporidium (Cp) is a ubiquitous waterborne pathogen that causes diarrheal disease worldwide. This pathogen causes life-threatening diarrheal disease in immunocompromised hosts, particularly AIDS patients. To date there is no effective treatment or va Health and Human Services, Department of / National Institutes of Health 7/26/2010
NEW YORK UNIVERSITY (INC) $2,093,862 Grant Trans-NIH Recovery Act Research Support: The real-time chemistry of life occurs at the interfaces of proteins and small chemicals present in the cellular environment. For the first time in history, sufficient information on the human proteome and its interacting chemogenome has accumulated in th Health and Human Services, Department of / National Institutes of Health 7/16/2010
DIAGENODE, INC. $10,630 Contract : The Bio-Tech equipment, UCD 300 Bioruptor is mainly used in universities and hospitals for research in DNA Shearing and Chromatin Shearing. The UCD 300 sonicator has different protocols with a digital timer. The UCD 300 is different from the hand held s Health and Human Services, Department of / National Institutes of Health 3/12/2010
UNIVERSITY OF CALIFORNIA, IRVINE $360,952 Grant Trans-NIH Recovery Act Research Support: Abstract An important goal of modern neuroscience is to understand how activity in identified neural circuits controls animal behavior. Establishing causal links between neural activity and behavior requires the ability to characterize the intrinsic memb Health and Human Services, Department of / National Institutes of Health 8/11/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $174,083 Grant Trans-NIH Recovery Act Research Support: Multiple studies have documented significantly lower plasma HIV-1 RNA concentrations (VL) in women compared to men at CD4+ T cell counts greater than 300 cells/mm3. Mechanisms underlying sex differences in VL are unknown. Because most HIV-1 replication oc Health and Human Services, Department of / National Institutes of Health 7/29/2010
LOYOLA UNIVERSITY NEW ORLEANS $66,670 Grant Trans-NIH Recovery Act Research Support: Synovial joints such as those that comprise the elbow, knee, and hip are extremely important for functioning in everday life. Cogenital defects, disease, and trauma to synovial joints, in particular to the articular cartilage that comprises a joint, are Health and Human Services, Department of / National Institutes of Health 7/01/2010
UNIVERSITY OF MARYLAND $49,198 Grant Trans-NIH Recovery Act Research Support: Antibiotic resistance is an increasing public health problem that is associated with considerable morbidity, mortality and costs. Given the reduced pace of antibiotic discovery and the approaching demographic shift towards an increasingly aged population, Health and Human Services, Department of / National Institutes of Health 8/02/2010
UNIVERSITY OF SOUTH FLORIDA $145,482 Grant Trans-NIH Recovery Act Research Support: This ARRA-funded grant supplement was awarded on July 26, 2010 to support and accelerate the pace of parent grant AI038178. . We expect that this supplement will allow us to conduct studies to better understand how the bacterium Bartonella henselae cau Health and Human Services, Department of / National Institutes of Health 7/26/2010
UNIVERSITY OF MARYLAND $311,250 Grant Trans-NIH Recovery Act Research Support: T cell responses against dominant tumor antigens (TA) can kill tumor cells but are less effective against poorly immunogenic (subdominant) TAs. Therefore, strategies are needed to induce potent and long-lasting T cell responses against dominant and subdom Health and Human Services, Department of / National Institutes of Health 9/17/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $98,192 Grant Trans-NIH Recovery Act Research Support: One of our stated goals was to investigate why retinoic acid receptor (RAR) alpha-selective antagonists showed good binding and activity profiles in vitro but were ineffective in inhibiting spermatogenesis. Samples of GPHR-00193316 (our synthesized sample Health and Human Services, Department of / National Institutes of Health 7/19/2010
UNIVERSITY OF ARIZONA $336,454 Grant Trans-NIH Recovery Act Research Support: Human cytomegalovirus is a ubiquitous virus infecting the majority of the population worldwide. This virus profoundly impacts human health through its complex disease states in individuals with weakened immune function. In addition, coexistence of the vir Health and Human Services, Department of / National Institutes of Health 8/02/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $11,464,018 Grant Trans-NIH Recovery Act Research Support: Bacteria resistant to antibiotic therapy accounted for an estimated 94,000 life-threatening infections and over 18,500 deaths in 2005, more deaths than from AIDS that year (Klevens et al. 2007). Resistant bacterial strains have been linked to aggressive a Health and Human Services, Department of / National Institutes of Health 9/16/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $3,495,470 Grant Trans-NIH Recovery Act Research Support: The immune system is profoundly affected by aging. Older individuals are at higher risk of death and disability from infections and cancer. The reason for such disproportionate susceptibility appears to be age-attributed impairment or suboptimal performan Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF CALIFORNIA, DAVIS $769,883 Grant Trans-NIH Recovery Act Research Support: This proposal seeks to merge two genomics cores serving as centralized shared resources funded by two independent programs into a single, efficient, cost effective, highly functioning, and integrated Mouse Genomics Core. The cores currently provide mouse Health and Human Services, Department of / National Institutes of Health 7/29/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $392,500 Grant Trans-NIH Recovery Act Research Support: The public health issues, economic impact and human suffering associated with alcohol abuse are staggering. Although alcohol-related research has been on-going for decades, there are many unanswered questions concerning mechanisms of alcohol-induced tissu Health and Human Services, Department of / National Institutes of Health 8/24/2010
UNIVERSITY OF MASSACHUSETTS $94,231 Grant Trans-NIH Recovery Act Research Support: Regular physical activity plays an important role in health and disease prevention. In our parent grant Correlates of Physical Activity in Adolescents with Intellectual Disabilities (ID), we are examining physical activity levels, sedentary behavior, and Health and Human Services, Department of / National Institutes of Health 7/21/2010
WOMEN & INFANTS HOSPITAL OF RHODE ISLAND $95,449 Grant Trans-NIH Recovery Act Research Support: The purpose of this supplement helps to achieve the goals of the ARRA, NICHD and the specific aimsby providing funding for the acquisition of additional needed equipment (Stereo Investigator system), which would improve our analytical capabilities, and ac Health and Human Services, Department of / National Institutes of Health 7/07/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $33,468 Grant Trans-NIH Recovery Act Research Support: This award was received on Sep 15. Therefore funds have not yet been spent. The purpose of this award is to purchase a new equipment and related services aiming to improve the efficiency of the parent study and scientific research. We have contacted Noldu Health and Human Services, Department of / National Institutes of Health 9/14/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $113,241 Grant Trans-NIH Recovery Act Research Support: This administrative supplement requests personnel funding for a postdoctoral associate to accelerate research on a multiplex PCR based screening diagnostic for enteropathogens. The original peer-reviewed research program was budgetarily cut which required Health and Human Services, Department of / National Institutes of Health 8/16/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $51,725 Grant Trans-NIH Recovery Act Research Support: This project will open communication channels and facilitate collaboration among IRB staff and members in Botswana and their counterparts at U.S. institutions that have large research activities ongoing in Botswana. A week long meeting and tour of sites i Health and Human Services, Department of / National Institutes of Health 9/25/2010
UNIVERSITY OF MASSACHUSETTS $430,000 Grant Trans-NIH Recovery Act Research Support: Identification of Transcription Factor Binding Sites in Human Promoters. Transcriptional regulation is a highly coordinated process in the human genome. A significant component of transcriptional regulation is the interaction between transcriptional facto Health and Human Services, Department of / National Institutes of Health 9/02/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $677,930 Contract : We will collect and provide samples of snap-frozen colorectal cancers with associated frozen lymphocytes and germline DNA, in conjunction with comprehensive clinical annotation to the two Biospecimen Core resource (BCR) laboratories that work on The Cance Health and Human Services, Department of / National Institutes of Health 8/26/2010
WASHINGTON UNIVERSITY, THE $72,299 Grant Trans-NIH Recovery Act Research Support: This is a request for a Recovery Act Administrative Supplement to grant R01 AI054483 entitled 'Immunity and Pathogenesis of a Novel Norovirus' in response to Notice NOT-OD-09-056. The goal of the parent grant is to examine the pathogenesis of, and immuni Health and Human Services, Department of / National Institutes of Health 7/06/2010
UNIVERSITY OF WASHINGTON $99,884 Grant Trans-NIH Recovery Act Research Support: Structural and functional studies will be carried out in order to provide a molecular level of understanding of the role of heme proteins in fundamental physiological processes, including respiration, metabolism, and the regulation of cellular responses. Health and Human Services, Department of / National Institutes of Health 8/25/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $1,399,981 Grant Trans-NIH Recovery Act Research Support: The goal of this application is the establishment of the Northern Manhattan center of excellence for comparative effectiveness research to eliminate disparities (NOMA-CERED) adjunct to the Columbia Center for the Health of Urban Minorities (CHUM) in respo Health and Human Services, Department of / National Institutes of Health 9/18/2010
WASHINGTON STATE UNIVERSITY $489,622 Grant Trans-NIH Recovery Act Research Support: Our goal is analysis of singly-charged intact proteins and complexes with part-per-million mass accuracy up to one MDa. We have recently created an inlet and large-radius frequency-adjusted linear quadrupole ion trap that is capable of capturing large qua Health and Human Services, Department of / National Institutes of Health 8/30/2010
UNIVERSITY OF CALIFORNIA, IRVINE $99,989 Grant Trans-NIH Recovery Act Research Support: This administrative supplement award provides funding for additional equipment to facilitate and speed up research in haplotype analysis over general pedigrees via distributed processing on a grid of computers. Preliminary work conducted under the parent Health and Human Services, Department of / National Institutes of Health 7/30/2010
JOHNS HOPKINS UNIVERSITY, THE $174,199 Grant Trans-NIH Recovery Act Research Support: Supplemental funding to our ongoing R01 grant (AI075025) is requested for the purpose of retaining a postdoctoral fellow and hiring a new postdoctoral fellow who would be essential to the proposed work and would greatly advance the specific aims of the pa Health and Human Services, Department of / National Institutes of Health 7/12/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $894,058 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant):: The objective of this application is the purchase of a BioScan NanoSPECT-CT scanner for in vivo small animal scanning. The requested purchase price is $1,063,916. Acquisition of the scanner will fulfill an unmet campu Health and Human Services, Department of / National Institutes of Health 7/08/2010
MAYO CLINIC $3,496,853 Grant Trans-NIH Recovery Act Research Support: This application is for funding of a study to characterize the human immune response before and after 2010-2011 influenza A/California/H1N1 seasonal vaccination by developing comprehensive immune profiles utilizing systems biology and bioinformatics appro Health and Human Services, Department of / National Institutes of Health 7/12/2010
UNIVERSITY OF PITTSBURGH THE $142,368 Grant Trans-NIH Recovery Act Research Support: This application is to request additional funds through ARRA supplement mechanism for the grant R21AI79288. Although the study from this grant yielded significant findings (published in the Journal of Biological Chemistry vol. 85, p 17380), few questions Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $5,500,668 Grant Trans-NIH Recovery Act Research Support: This application addresses the thematic area, 'Using Science to Enable Health Care Reform.' The future of the Medicare program poses one of the greatest policy challenges to the United States. This extraordinarily popular program has brought universal hea Health and Human Services, Department of / National Institutes of Health 9/21/2010
DUKE UNIVERSITY $96,367 Grant Trans-NIH Recovery Act Research Support: Cilia are ancient organelles present in most eukaryotic cells. Recent studies have shown that ciliarydysfunction leads to a multitude of clinical phenotypes, collectively termed the ciliopathies. Studies byour group and others have shown that mutations in Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF MIAMI $45,900 Grant Trans-NIH Recovery Act Research Support: The immune system provides the bodyG??s primary defense against infectious diseases. However, de-regulated immune system can attack healthy cells in many parts of the body rather than pathogens resulting in autoimmune diseases. There are more than 80 typ Health and Human Services, Department of / National Institutes of Health 8/30/2010
UNIVERSITY OF MASSACHUSETTS $385,491 Grant Trans-NIH Recovery Act Research Support: This ARRA award will provide funds for the purchase of a quantitative real-time PCR (qPCR) instrument and full-time funding for a graduate student to complete transcriptional profiling for the ABCT and GST genes from the louse using qPCR. Candidate ABCT a Health and Human Services, Department of / National Institutes of Health 9/13/2010
RHEONIX, INC. $233,044 Grant Trans-NIH Recovery Act Research Support: This supplemental grant is focused on expanding the scope of work of the original parental grant. While the parental grant is focused on the rapid molecular detection of sexually transmitted diseases (STDs) in point-of-care markets, the supplemental effo Health and Human Services, Department of / National Institutes of Health 8/02/2010
GEORGETOWN UNIVERSITY (THE) $147,461 Contract : Building on top of the previous effort, in the second quarter, we > implemented and tested the Windows and Linux versions of the library. > As part of the ITK version 4 effort and one of the A2D2 > subcontractors, we also fulfilled our obligation to IT Health and Human Services, Department of / National Institutes of Health 8/04/2010
GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. $494,750 Grant Trans-NIH Recovery Act Research Support: The major goal of the current proposal is to obtain funds for the purchase of a Becton Dickinson FACSAria II Cell Sorter Flow Cytometer (BD-FACS) system, including a Becker BioPROtect III Bio-containment enclosure that is specifically designed for analyse Health and Human Services, Department of / National Institutes of Health 6/28/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $260,000 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The objectives of this proposal are to purchase a state-of-the-art multiplex assay system for the detection of soluble molecules (cytokines, growth factors, metabolic markers, hormones, mediators of inflammation, other Health and Human Services, Department of / National Institutes of Health 7/29/2010
SCRIPPS RESEARCH INSTITUTE, THE $772,062 Grant Trans-NIH Recovery Act Research Support: The overall purpose is to study the cellular efficacy of designed small molecules targerting the RNA that causes myotonic dystrophy type 1 (DM1). Compounds will be optimized by competing in vitro assays to determine potency and in vivo assays to determin Health and Human Services, Department of / National Institutes of Health 9/01/2010
JWMC, LLC. $199,404 Grant Trans-NIH Recovery Act Research Support: Clinical encounters require the creation of an enormous amount of documentation. This documentation is tedious, time-consuming, and, in practice, is usually created hours after the encounter has occurred. The requirement to create this documentation place Health and Human Services, Department of / National Institutes of Health 8/19/2010
UNIVERSITY OF NEW MEXICO $156,871 Grant Trans-NIH Recovery Act Research Support: Background: Pregnancy and childbirth alter pelvic floor anatomy and function. Over 4 million women give birth each year in the United States, and most experience genital tract trauma, including damage to the nerves and musculature of the pelvic floor. Thi Health and Human Services, Department of / National Institutes of Health 7/29/2010
DANA-FARBER CANCER INSTITUTE, INC. $1,500,000 Grant Trans-NIH Recovery Act Research Support: Our goal is to build an infrastructure to discover novel viruses associated with human cancer from next-generation sequencing data, using a sequence-based computational subtraction approach that we developed. This proposed project responds to the ARRA Res Health and Human Services, Department of / National Institutes of Health 7/12/2010
BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS $30,000 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Strategic Approach to Facilitating Evacuation by Health Assessment of Vulnerable Elderly in Nursing Homes (SAFE HAVEN Study). Since the events of September 11th 2001, billions of federal dollars have been devoted to im Health and Human Services, Department of / National Institutes of Health 7/30/2010
PALO ALTO INSTITUTE FOR RESEARCH AND EDUCATION, INC. $491,771 Grant Trans-NIH Recovery Act Research Support: Influenza viruses are respiratory tract pathogens that infect through the respiratory mucosa and cause significant morbidity and mortality in all age groups. Influenza vaccines, including live attenuated influenza vaccine (LAIV) given via intranasal spay Health and Human Services, Department of / National Institutes of Health 8/02/2010
DOMINICAN UNIVERSITY $362,442 Grant Trans-NIH Recovery Act Research Support: This project explores the genetic and neural changes that mediate long-term memory for habituation, a simple form of memory that is shared across the entire animal kingdom. By studying the mechanisms of habituation in a simple model organism (Aplysia cali Health and Human Services, Department of / National Institutes of Health 7/14/2010
JOHNS HOPKINS UNIVERSITY, THE $222,415 Grant Trans-NIH Recovery Act Research Support: Chronic kidney disease (CKD) affects an estimated 19 million adults in the US, and is associated with an elevated risk of cardiovascular disease (CVD) and mortality. Clinical practice guidelines define CKD on the basis of both albuminuria and decreased ki Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF IOWA, THE $225,000 Contract : Refactoring the ITK FEM Framework Health and Human Services, Department of / National Institutes of Health 6/21/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $97,127 Grant Trans-NIH Recovery Act Research Support: This 12-month mentored development award will allow the PI, Dr. May Wang, a nutritional epidemiologist, to enrich her current research program with new theories, methods, and approaches from the fields of sociology, demography, and psychology to address h Health and Human Services, Department of / National Institutes of Health 9/14/2010
UNIVERSITY OF PITTSBURGH THE $15,367 Grant Trans-NIH Recovery Act Research Support: This award is for the purchase of a Tetra 2 four-bay thermal cycler chasis. Many of the genes associated with orofacial clefting encode regulatory proteins that are prominent regulators of gene expression, associated with a wide variety of cellular and d Health and Human Services, Department of / National Institutes of Health 6/29/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $200,000 Grant Trans-NIH Recovery Act Research Support: Coordinated contractions of the smooth muscle coat surrounding the renal pelvis and the ureter are essential for draining urine out of the kidney. Congenital defects that impair this peristaltic process are common, and can lead to permanent kidney damage. Health and Human Services, Department of / National Institutes of Health 8/18/2010
UNIVERSITY OF KENTUCKY $174,761 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Located in rural Kentucky, the state with the highest adolescent overweight rate in the nation, the proposed project examines the feasibility of using a farm to school program as a health intervention. Farm to school p Health and Human Services, Department of / National Institutes of Health 9/01/2010
UNIVERSITY OF ROCHESTER $959,658 Grant Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (05): Comparative Effectiveness Research and Specific Challenge topic 05-LM-104* Value of 'Virtual Reality' Interaction in Improving Compliance with Diabetic Regimen. Diabetes has become a serious public hea Health and Human Services, Department of / National Institutes of Health 8/24/2010
MAYO CLINIC $148,168 Grant Trans-NIH Recovery Act Research Support: Obesity is an important public health problem. Endoscopic intra-gastric injection of botulinum toxin A (BTA) has been reported to cause weight loss, however results of published studies vary. Our long-term objective is to determine whether alterations in Health and Human Services, Department of / National Institutes of Health 7/27/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $462,925 Grant Trans-NIH Recovery Act Research Support: The specific scientific goals of this Administrative Supplement are: 1) Analyze factors contributing to cesarean birth and labor induction in nulliparous women; 2) Characterize race/ethnicity disparities and stress markers as they relate to preterm birth Health and Human Services, Department of / National Institutes of Health 7/08/2010
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY $99,989 Grant Trans-NIH Recovery Act Research Support: Metals play a crucial role in helping to shape the intricate three-dimensional structure of RNA and to control its many functions that are key to all forms of life. We have found that 15N NMR is an excellent non- perturbing method that is particularly sen Health and Human Services, Department of / National Institutes of Health 8/25/2010
UNIVERSITY OF ROCHESTER $525,577 Grant Trans-NIH Recovery Act Research Support: Infections caused by Staphylococcus aureus span a wide clinical spectrum, ranging from asymptomatic nasal carriage to endocarditis, bone and joint infections and lethal shock. Increasing rates of S. aureus infection and the emergence of community-acquired Health and Human Services, Department of / National Institutes of Health 8/19/2010
EMORY UNIVERSITY $102,326 Grant Trans-NIH Recovery Act Research Support: This supplement develops a new collaboration between Dr. Craig Coopersmith (PI, parent grant) and Dr. Nicholas Davidson, Professor of Medicine, Director Division of Gastroenterology Washington University. Dr. CoopersmithG??s research focuses on understand Health and Human Services, Department of / National Institutes of Health 9/01/2010
SCHEPENS EYE RESEARCH INSTITUTE, INC., THE $529,375 Grant Trans-NIH Recovery Act Research Support: The overall goal of the research is to test the hypothesis that fibroblast growth factor 15 (FGF15) is a key signal regulating the transition from neurogenesis to gliogenesis in the developing cortex and that drugs of abuse may alter FGF15 signaling to ca Health and Human Services, Department of / National Institutes of Health 6/05/2009
JOHNS HOPKINS UNIVERSITY, THE $115,224 Grant Trans-NIH Recovery Act Research Support: Project Title: Sleep in Rats: From Conceptualization to Measurement, Analysis and Interpretation My short-term goal for the duration of this 12-month Career Development Award is to build a substantial knowledge base regarding sleep from conceptualization Health and Human Services, Department of / National Institutes of Health 9/17/2010
UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON $908,442 Grant Trans-NIH Recovery Act Research Support: Ebola, Marburg, and Lassa viruses are enigmatic emerging pathogens that cause severe Hemorrhagic Fever (HF) in humans and nonhuman primates. Outbreaks occur regularly in the case of Lassa and sporadically in the case of the flioviruses in parts of Africa Health and Human Services, Department of / National Institutes of Health 9/24/2010
UNIVERSITY OF LOUISVILLE $266,000 Grant Trans-NIH Recovery Act Research Support: While advances have been made in characterizing the synaptic organization and visual response properties of the pulvinar nucleus, itsG?? exact contributions to the coding of visual signals have remained elusive. The proposed experiments are designed to an Health and Human Services, Department of / National Institutes of Health 9/14/2010
TRUSTEES OF DARTMOUTH COLLEGE $816,000 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Dartmouth's Norris Cotton Cancer Center (NCCC) submits this competitive renewal application for NCI Cancer Center Support Grant funding for Years 31-35. NCCC is a matrix Center at Dartmouth-Hitchcock Medical Center (D Health and Human Services, Department of / National Institutes of Health 9/16/2010
DUKE UNIVERSITY $54,200 Grant Trans-NIH Recovery Act Research Support: Enhancing capacity in human subject protections for Chinese research studies The goal of this proposal is to enhance the capacity of investigators in the People's Republic of China to meet both their national standards for protecting human research subjec Health and Human Services, Department of / National Institutes of Health 9/25/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $910,993 Grant Trans-NIH Recovery Act Research Support: This study will compare several variations of emergency-room?based HIV-testing policies in order to determine how HIV test acceptance rates can be increased. The study evaluates the effectiveness of interventions designed using principles from behavioral Health and Human Services, Department of / National Institutes of Health 9/21/2010
JOHNS HOPKINS UNIVERSITY, THE $50,000 Grant Trans-NIH Recovery Act Research Support: Global health research that involves human subjects in limited-resource setting countries continues to expand. Funding agencies such as National Institute of Health (NIH) are becoming more involved in ethically challenging scientific areas such as HIV/AID Health and Human Services, Department of / National Institutes of Health 9/29/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $51,714 Contract : DESCRIPTION (provided by applicant):The University of Michigan SPORE program has been continuously funded since 2001 and engaged in translational research with a large longitudinal molecular epidemiology project that includes collection of tumor and norma Health and Human Services, Department of / National Institutes of Health 8/26/2010
MOREHOUSE SCHOOL OF MEDICINE, INC., THE $13,320,021 Grant Trans-NIH Recovery Act Research Support: The persistence of health disparities in medically underserved minority communities remains one of the most vexing public health problems facing our nationthe etiology of racial/ethnic differences in health involves dynamic interactions between genetic, b Health and Human Services, Department of / National Institutes of Health 9/25/2010
LOUISIANA STATE UNIVERSITY SYSTEM $374,573 Grant Trans-NIH Recovery Act Research Support: The Quality of Life Prostate Cancer Project (Q-PCaP) is a prospective follow-up study of the Louisiana cohort assembled for the the North Carolina-Louisiana Prostate Cancer Project (PCaP), a population-based study conducted from July 2004 through August 2 Health and Human Services, Department of / National Institutes of Health 8/26/2010
JOHNS HOPKINS UNIVERSITY, THE $232,945 Grant Trans-NIH Recovery Act Research Support: Supplemental funding to our ongoing R01 grant (AI072265) is requested for the purpose of retaining personnel who would be essential to the proposed work. We are also requesting funds to pay for the development of a new knockout mouse and purchase supplies Health and Human Services, Department of / National Institutes of Health 7/12/2010
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH $191,750 Contract : Memorial Sloan Kettering Cancer Center has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of thyroid papillary specimens (118 cases). The collection Health and Human Services, Department of / National Institutes of Health 8/05/2010
SAIC FREDERICK, INC $7,743,000 Contract : Support has been awarded to collaboratively build and use the standards, infrastructure, tools and policies needed for the FDA to receive, process and analyze data in a standardized electronic format, including analyses across multiple studies. Health and Human Services, Department of / National Institutes of Health 7/13/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $229,473 Grant Trans-NIH Recovery Act Research Support: Adolescence is a time of heightened vulnerability for risk taking behavior and poor decision making that can give rise to substance use and externalizing behavior. Emerging evidence from developmental neuroscience suggests that risk taking behavior increa Health and Human Services, Department of / National Institutes of Health 9/23/2010
BAYLOR COLLEGE OF MEDICINE $261,638 Grant Trans-NIH Recovery Act Research Support: Statement of Purpose (15 words): To enable large RAM genomic sequence analysis and meet the challenge of next-generation DNA sequencing. Abstract: High-throughput, short read DNA sequencing technologies have transformed sequence data production, necess Health and Human Services, Department of / National Institutes of Health 9/01/2010
AEROTEK, INC. $56,896 Contract : Services of individuals to assist in coordination of collection, analysis, and reporting of international research & Training. Health and Human Services, Department of / National Institutes of Health 8/20/2010
UNIVERSITY CORPORATION, THE $69,238 Grant Trans-NIH Recovery Act Research Support: The dimorphic bacterium Caulobacter crescentus is a model organism for studying the bacterial cell cycle. Its asymmetric cell division results in one swarmer and one stalked cell progeny. Motile swarmer cells can not undergo DNA replication until they dif Health and Human Services, Department of / National Institutes of Health 7/16/2010
UNIVERSITY OF WASHINGTON $213,725 Grant Trans-NIH Recovery Act Research Support: This proposal is for an non-competitive administrative supplement to R01AI078781, Regulation of APOBEC3G enzymatic activity in HIV-infected primary human T cells, which was funded from 8/1/09 - 07/31/13. The goal of Aims 1 & 2 is to test whether signaling Health and Human Services, Department of / National Institutes of Health 9/20/2010
UNIVERSITY OF WASHINGTON $4,030,115 Grant Trans-NIH Recovery Act Research Support: We propose to determine on a genome-wide and population-wide scale genetic variations across all major diarrheal and extra-intestinal E. coli pathotypes, with the analysis of positive selection footprints in genes shared by multiple strains. The main fo Health and Human Services, Department of / National Institutes of Health 9/29/2010
SEATTLE CHILDREN'S HOSPITAL $95,451 Grant Trans-NIH Recovery Act Research Support: Spontaneous and ENU-induced mouse mutants are a tremendously valuable resource for their ability to model human disease. The study of these mutants has provided new insights into basic clinically relevant biological mechanisms, which would not have been a Health and Human Services, Department of / National Institutes of Health 8/09/2010
EAST CAROLINA UNIVERSITY $50,000 Grant Trans-NIH Recovery Act Research Support: The supplement will help us explore alternative approach to knockdown two proteins (caveolin-3 and calmodulin) in neurons of two brainstem areas, which are implicated in cardiovascular control and in mediating the pressor effect of ethanol. We will utili Health and Human Services, Department of / National Institutes of Health 9/03/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $498,934 Grant Trans-NIH Recovery Act Research Support: Broad Challenge Areas: 1) Clinical Research (04), specific topic 04-AI-101* (Develop novel methods and address key questions in mucosal immunology), and 2) Biomarker Discovery and Validation (03), specific topic 03-AI-101 (Identification, characterization Health and Human Services, Department of / National Institutes of Health 9/13/2010
UNIVERSITY OF WASHINGTON $223,228 Grant Trans-NIH Recovery Act Research Support: Low income or poverty is related to lower effortful control, which is critical to the development of adaptive functioning. Effortful control refers to executive attentional and inhibitory control mechanisms and shows a sharp developmental increase in the Health and Human Services, Department of / National Institutes of Health 9/07/2010
UNIVERSITY OF NEBRASKA $499,013 Grant Trans-NIH Recovery Act Research Support: This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in oth Health and Human Services, Department of / National Institutes of Health 9/20/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $30,642 Grant Trans-NIH Recovery Act Research Support: Our project addresses key issues in adult-to-adult living donor liver transplantation (LDLT). The Main Trial is an extension of the ongoing A2ALL Study - our program is an active participant and the leading enroller of patients to this trial. The current Health and Human Services, Department of / National Institutes of Health 6/22/2010
TRUSTEES OF DARTMOUTH COLLEGE $1,963,302 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (Provided by the applicant): Emerging imaging technologies are an important component of efforts to effectively detect and treat cancer. The American Recovery and Reinvestment Act of 2009 specifically targets the development of comparative Health and Human Services, Department of / National Institutes of Health 9/23/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $50,000 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The immune mechanisms that underlie the pathogenesis and/or regulation of human autoimmune diseases represent a very important but significantly understudied aspect of human disease. Our understanding of autoimmunity a Health and Human Services, Department of / National Institutes of Health 8/02/2010
TEXAS BIOMEDICAL RESEARCH INSTITUTE $207,092 Grant Trans-NIH Recovery Act Research Support: Drug resistance is the major obstacle to control of malaria and the spread of resistance has increased malaria mortality over recent decades. Identification of parasite genes that influence drug response would improve our ability to monitor resistance spr Health and Human Services, Department of / National Institutes of Health 9/13/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $3,778,497 Grant Trans-NIH Recovery Act Research Support: This application responds to the needs and opportunities in Applying Genomics and Other High Throughput Technologies. We aim to use a newly-developed mass spectroscopy technique, FLEXIQuant, to provide absolute quantitation of the levels of 1,000 proteins Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $930,000 Grant Trans-NIH Recovery Act Research Support: In response to the NIH Notice NOT-RR-10-001, the UAB Comprehensive Cancer Center requests an administrative supplement of $895,762 to consolidate its two geographically separated NMR shared facilities of the Cancer Center Support Grant (CCSG) to form a H Health and Human Services, Department of / National Institutes of Health 9/28/2010
UNIVERSITY OF UTAH, THE $647,286 Grant Trans-NIH Recovery Act Research Support: In neurobiology, confocal technology is widely used for studying the three-dimensional structure of the nervous system. Visualization tools are required for qualitative analysis, which give an overall evaluation of the experiment results, helps decide whi Health and Human Services, Department of / National Institutes of Health 9/10/2010
SCRIPPS RESEARCH INSTITUTE, THE $915,338 Grant Trans-NIH Recovery Act Research Support: Funding was provided to support the development of Mutagenetix, a database of mutations induced by ENU. Both web programming and illustration are funded. Deliverables include the illustration of molecular pathways and the development of Wiki-like histor Health and Human Services, Department of / National Institutes of Health 7/26/2010
UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) $17,630 Grant Trans-NIH Recovery Act Research Support: The award was a Summer Student Supplement to the grant, G?Inhibition of Lung Defenses by Air Pollutant ParticulatesG?. This grant provided a summer research experience for one high school student and one college student in health-related scientific resea Health and Human Services, Department of / National Institutes of Health 6/09/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $343,453 Contract : In this project we will develop a new framework for performing level set based segmentation using the Insight Toolkit software library. Level sets are a powerful and flexible class of algorithms for recognizing objects of interest in images. Our new Insig Health and Human Services, Department of / National Institutes of Health 8/03/2010
NORTHWESTERN UNIVERSITY $33,482 Grant Trans-NIH Recovery Act Research Support: The overarching goal of this proposal is to address the A2ALL Funding Opportunity Announcement objective to improve understanding of long-term health and well-being of living donors and on the efficacy of living donor liver transplantation (LDLT). Primary Health and Human Services, Department of / National Institutes of Health 9/30/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $1,012,718 Grant Trans-NIH Recovery Act Research Support: We intend to build on the progress we have made in the previous granting period with two overall objectives in mind: the first is to extend our knowledge of the human immune response to influenza vaccine much more broadly and deeply across different age g Health and Human Services, Department of / National Institutes of Health 8/02/2010
RESEARCH TRIANGLE INSTITUTE $211,133 Grant Trans-NIH Recovery Act Research Support: This project will provide results on an experimental approach to the reduction of bias and variance in survey estimates. If successful, less data could be collected while providing more accurate results. Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF WISCONSIN SYSTEM $2,479,629 Grant Trans-NIH Recovery Act Research Support: This proposal addresses three thematic areas of RFA-OD-10-005 Recovery Act Limited Competition: NIH Director's Opportunity for Research in Five Thematic Areas (RC4). Reinvigorating the Biomedical Research Community: By combining a multidisciplinary team o Health and Human Services, Department of / National Institutes of Health 9/30/2010
SEATTLE BIOMEDICAL RESEARCH INSTITUTE $338,901 Grant Trans-NIH Recovery Act Research Support: Funds from this administrative supplement are being used to support a malaria research project with the specific aim of the identification of novel preerythrocytic stage Plasmodium vivax antigens that are the targets of immune responses in naturally expos Health and Human Services, Department of / National Institutes of Health 8/09/2010
MONJAN, USHA $0 Contract : RECOVERY Coordination of the reviews of ARRA administrative supplements by the Program Analysts prior to their being reviewed by the relevant Health Scientist Administrators. Health and Human Services, Department of / National Institutes of Health 8/06/2009
TRUSTEES OF TUFTS COLLEGE INC $1,303,141 Grant Trans-NIH Recovery Act Research Support: STEC strains causing kidney failure are serious Category B pathogens associated primarily with food and waterborne disease. They represent an important global emerging infection with relevance to both food-borne illness and bioterrorism. The virulence of Health and Human Services, Department of / National Institutes of Health 8/02/2010
UNIVERSITY OF LOUISVILLE $50,000 Grant Trans-NIH Recovery Act Research Support: This supplement will study whether or not ethanol-induced redox changes in the liver decrease the intracellular SAM/SAH ratio, thus leading to down-regulation of SAM-dependent methylation. The experiments will be performed in the isolated, perfused rat l Health and Human Services, Department of / National Institutes of Health 8/09/2010
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH $277,500 Contract : Memorial Sloan Kettering Cancer Center has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of colon specimens (N=150). The collection of the specimens Health and Human Services, Department of / National Institutes of Health 6/15/2010
WASHINGTON UNIVERSITY, THE $3,300,000 Grant Trans-NIH Recovery Act Research Support: In summary, this proposal focuses on two of the five themes outlined in the RFA-OD-10-005: 'Applying Genomics and Other High Throughput Technologies' and 'Translating Basic Science Discoveries into New and Better Treatments' and is ready for immediate imp Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $258,534 Grant Trans-NIH Recovery Act Research Support: Type I interferons (IFNa/p) represent a group of cytokines that finds widespread clinical application in the treatment of autoimmune disorders such as multiple sclerosis, however; the mechanisms by which IFNa/p exert their beneficial effects remain elusiv Health and Human Services, Department of / National Institutes of Health 7/20/2010
BUSINESS IMAGING SYSTEMS, INC. $62,000 Contract : Records Management System and Deployment Assistance for Policy and Program Records from the Implementation of the American Recovery and Reinvestment Act (ARRA) Health and Human Services, Department of / National Institutes of Health 8/15/2010
NATIONAL OPINION RESEARCH CENTER $15,000 Grant Trans-NIH Recovery Act Research Support: Wave I of NSHAP, completed in 2005-2006, collected a range of biological and psychosocial indicators relevant to MS. A wide range of measures of sexual behavior and sexual dysfunctions were also included. These and additional indicators are being collecte Health and Human Services, Department of / National Institutes of Health 7/26/2010
MIND RESEARCH NETWORK, THE $98,920 Grant Trans-NIH Recovery Act Research Support: This award provided funds to purchase a child friendly EEG system to accompany our MEG system to allow for fully integrated MEG/EEG data collection in child studies. This will allow us to capitalize on the advantages of each technique. MEG signals do not Health and Human Services, Department of / National Institutes of Health 7/21/2010
WYLE INFORMATION SYSTEMS, LLC $224,680 Contract : Enhancing Peer Review Project G?? will support for the Enhancing Peer Review Project that will address additional technical requirements identified by the NIH Peer Review Working Groups. These enhancements will promote the Peer Review Oversight committee Health and Human Services, Department of / National Institutes of Health 5/18/2010
OREGON HEALTH & SCIENCE UNIVERSITY $313,000 Grant Trans-NIH Recovery Act Research Support: The role of maternal neutralizing antibodies (NAbs) in determining whether an infant becomes infected during Mother to Child Transmission (MTCT) of HIV-1 is unclear. Higher levels of both autologous and heterologous NAbs are associated with non-transmissi Health and Human Services, Department of / National Institutes of Health 9/24/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $39,657 Grant Trans-NIH Recovery Act Research Support: Seven transmembrane receptors (GPCRs) are the largest single druggable target of the human proteome, such that over 50% of all current drugs used to ameliorate human disease and suffering are targeted to GPCRs. The Siderovski lab originally discovered a n Health and Human Services, Department of / National Institutes of Health 8/27/2010
CARNEGIE INSTITUTION OF WASHINGTON $49,527 Grant Trans-NIH Recovery Act Research Support: The award was a Supplement to the NIH Parent Grant 5RO1HD042215-07, Left-Right Asymmetry of the Developing Diencephalon under NOT-OD-09-060 to Principal Investigator Dr. Marnie Halpern. The funds are being used to purchase an Olympus MVX10 MacroScope wi Health and Human Services, Department of / National Institutes of Health 7/07/2010
G BAILEY COMPANY, INC $2,500,000 Contract : RECOVERY - Building 60 - Underground Chilled and Water and High Pressure Steam Piping. Health and Human Services, Department of / National Institutes of Health 9/14/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $148,343 Grant Trans-NIH Recovery Act Research Support: Parent grant: Dissemination of a Weight Management Program among US Veterans Supplement: Disseminating and Implementing Evidence-Based Computer-Tailored Cancer Control Interventions Description: To test recruitment via social networking, specifically Face Health and Human Services, Department of / National Institutes of Health 9/08/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $182,835 Grant Trans-NIH Recovery Act Research Support: This is an administrative supplement providing additional funds to allow us to accelerate our analysis of target antigens in protection and T cell assays. These experiments fall within the scope of Specific Aims 2 and 3 as described in the original applic Health and Human Services, Department of / National Institutes of Health 7/26/2010
CHILDREN'S HOSPITAL CORPORATION, THE $2,993,464 Grant ARRA Accelerating Adoption of Comparative Effectiveness Research (CER): The Agency for Healthcare Research and Quality and the Institute of Medicine have called for the adoption of improved handoff tools and processes to address the high incidence of harmful communication failures in hospitals. Compa... Show more Health and Human Services, Department of / National Institutes of Health 9/21/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $999,186 Grant Trans-NIH Recovery Act Research Support: This administrative supplement provides $999,945 for 1 year, effective 9/15/10-8/31/11. Funds were approved for the following items: statistician, statistical programmer, Center for Biostatistics and AIDS Research (CBAR) computing, and consortium costs fo Health and Human Services, Department of / National Institutes of Health 9/22/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $237,750 Grant Trans-NIH Recovery Act Research Support: Drug addiction is a devastating disorder marked by compulsive drug use, high propensity to relapse to drug taking, and cognitive deficits. Drugs of abuse, including morphine, lead to a decrease in the number of new neurons in the hippocampus, a brain regi Health and Human Services, Department of / National Institutes of Health 9/27/2010
CHILDRENS HOSPITAL OF PHILADELPHIA $857,577 Grant Trans-NIH Recovery Act Research Support: We propose to test the hypothesis that mitochondrial dysfunction is an important factor in the etiology of autism spectrum disorders (ASD). The mitochondria play four central roles in cell and tissue function: they provide most of the energy, generate muc Health and Human Services, Department of / National Institutes of Health 9/10/2010
TRUSTEES OF TUFTS COLLEGE INC $383,750 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Over the past five years, thanks to support from NICHD, we have been actively studying the time-course and neural correlates of word processing in university students learning a second language. In this work we use the Health and Human Services, Department of / National Institutes of Health 9/07/2010
TECAN US INC. $63,453 Contract : Sequencer, Freedom EVO 75 SOLID Library Prep Health and Human Services, Department of / National Institutes of Health 9/22/2010
WESTAT, INC. $2,457,255 Contract : The purpose of the contract is to provide services for the planning, implementation, and coordination of Multi-cohort Eating and Activity Study for Understanding Reporting Error (MEASURE). The scope of this project is establishing the MEASURE Coordinatin Health and Human Services, Department of / National Institutes of Health 8/30/2010
UNIVERSITY OF SOUTH FLORIDA $1,400,000 Grant Trans-NIH Recovery Act Research Support: This project is to support the establishment of a Center of Excellence for conducting Comparative Effectiveness Research for Eliminating Disparaties (CERED). The USF Moffitt CERED will conduct a comparative effectiveness research project regarding inform Health and Human Services, Department of / National Institutes of Health 7/31/2010
STERLING COMPUTERS CORPORATION $14,049 Contract : Qty 61 CB022A#B1H OFFICEJET PRO 8500 AIO INKJETPR P/C/S/F Qty 61 C4902AN#140 HP NO 940 GENUINE INK CART BLK RETAIL PKG OJ Health and Human Services, Department of / National Institutes of Health 9/22/2010
NORTHWESTERN UNIVERSITY $85,846 Grant Trans-NIH Recovery Act Research Support: Abnormalities in the metabolism of the essential metal ion copper result in a spectrum of devastating human diseases such as Menkes and Wilsons Disease, and bear on neurological disorders such as Alzheimer's and Creutzfeldt-Jakob Disease. Acknowledging t Health and Human Services, Department of / National Institutes of Health 8/17/2010
MICHIGAN STATE UNIVERSITY $379,331 Grant Trans-NIH Recovery Act Research Support: In order to understand the molecular mechanisms responsible for many human diseases and develop new drugs and therapies, it is critical to solve the structures of membrane proteins. Membrane proteins constitute approximately one-third of all proteins enc Health and Human Services, Department of / National Institutes of Health 9/07/2010
COLORADO STATE UNIVERSITY $249,406 Grant Trans-NIH Recovery Act Research Support: Fatty liver disease is poorly understood and the factors that promote liver damage in this disease have not been identified. This application investigates the hypothesis that the amount of saturated fatty acids delivered to or stored within the liver cont Health and Human Services, Department of / National Institutes of Health 7/30/2010
UNIVERSITY OF CINCINNATI $1,722,932 Grant Trans-NIH Recovery Act Research Support: This application addresses one of the five thematic areas in the RFA-OD-10-005: Focusing on Global Health. Electronic waste (e-waste) has become a global environmental health problem because of its huge amount of production worldwideG??G??approximately 20 Health and Human Services, Department of / National Institutes of Health 9/30/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $378,000 Contract : RECOVERY: Computational Thinking to Support Clinicians and Biomedical Scientists Health and Human Services, Department of / National Institutes of Health 9/23/2010
THREE SPRINGS SCIENTIFIC INC $418,400 Contract : 172 African Green Chlorocebus Aethiops (12/01/10---52 Chlorocebus aethiops African Green SPF, male or female; 05/11/11---30 Chlorocebus aethiops African Green SPF, male or female; 11/01/11---28 chlorbebus aethiops African Green, SPF, male or female; 05/01 Health and Human Services, Department of / National Institutes of Health 8/16/2010
BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON $449,750 Grant Trans-NIH Recovery Act Research Support: Dendritic cells are important in initiating both inflammatory responses and immune responses. These studies will help elucidate how dendritic cell function is regulated both in the absence and presence of infection. This work will give insights into how t Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF MARYLAND $190,000 Grant Trans-NIH Recovery Act Research Support: This proposal is submitted in response to RFA-DK-06-501 for continuation of the Urinary Incontinence Treatment Network (UITN) Clinical Center at University of Maryland Baltimore (UMB). Phase II will focus on conduct of the Trial of Mid-Urethral Slings (TO Health and Human Services, Department of / National Institutes of Health 9/30/2010
TRUSTEES OF BOSTON UNIVERSITY $786,250 Grant Trans-NIH Recovery Act Research Support: Prion diseases are fatal neurodegenerative disorders of humans and animals. They result from conversion of PrPC, a normal membrane glycoprotein into PrPSc, a conformationally altered isoform that is infectious in the absence of nucleic acid. Most exogenou Health and Human Services, Department of / National Institutes of Health 7/02/2010
BAYLOR COLLEGE OF MEDICINE $93,900 Grant Trans-NIH Recovery Act Research Support: Supplementary request for acceleration of the project: As indicated above, we now need to characterize the specific transcription factors and molecular events by which ERK1/2 controls the expression of genes that impact both ovulation (including COC expan Health and Human Services, Department of / National Institutes of Health 8/11/2010
JOHNS HOPKINS UNIVERSITY, THE $131,079 Grant Trans-NIH Recovery Act Research Support: This award is supplemental funding through the American Recovery Act Administrative Supplement mechanism (NOT-OD-056) for an NIAID funded R21 grant, ?Testing Modified Approaches to Informed Consent? (1R21AI074005-01A1). This purpose of this supplement is Health and Human Services, Department of / National Institutes of Health 9/07/2010
BETH ISRAEL DEACONESS MEDICAL CENTER INC $434,791 Grant Trans-NIH Recovery Act Research Support: This proposal is designed to address the issue of innate immune responses to allografts following transplantation, an area that is poorly studied and ill characterized. The focus of this project is on reciprocal interactions between host alloreactive NK c Health and Human Services, Department of / National Institutes of Health 8/23/2010
NEW YORK UNIVERSITY (INC) $181,956 Grant Trans-NIH Recovery Act Research Support: These studies are designed to examine 44 human anti-V3 monoclonal antibodies (mAbs) with respect to how the immunoglobulin (Ig) variable heavy (VH) and variable light (VL) chain gene usage determines Ab cross-reactivity and function. The studies are based Health and Human Services, Department of / National Institutes of Health 8/23/2010
MAYO CLINIC $334,663 Grant Trans-NIH Recovery Act Research Support: Primary sclerosing cholangitis (PSC) is one of the most common cholestatic liver diseases among adults in the USA. This disease affects young and middle-aged men and women and may progress to end-stage liver disease requiring liver transplantation. In add Health and Human Services, Department of / National Institutes of Health 7/23/2010
ANALYTICAL BIOLOGICAL SERVICES INC $2,312,715 Contract : We have been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically to establish a Tissue Source Site (TSS) Network capable of delivering clinically annotated biospecimens through either or both retr Health and Human Services, Department of / National Institutes of Health 9/27/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $598,637 Grant Trans-NIH Recovery Act Research Support: The CALGB is comprised of 26 academic medical centers and over 200 affiliated community hospitals joined in the pursuit of improved cancer treatment and better understanding of tumor biology and cancer treatment outcomes via the conduct of controlled clin Health and Human Services, Department of / National Institutes of Health 7/26/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $166,846 Grant Trans-NIH Recovery Act Research Support: Antigenically naive CD4 expressing a?-T cell receptors are critical for generating immune responses to neoantigens, and are produced de novo within the thymus as mature CD4+CD8- thymocytes. These enter the periphery to become recent thymic emigrants (RTEs Health and Human Services, Department of / National Institutes of Health 7/06/2010
WASHINGTON UNIVERSITY, THE $118,560 Grant Trans-NIH Recovery Act Research Support: The auditory system has evolved for the effective processing of auditory information important for the species, so the functional organization of the cerebral speech areas and neural mechanisms for processing speech in humans cannot be explored without di Health and Human Services, Department of / National Institutes of Health 7/28/2010
SOCIAL & SCIENTIFIC SYSTEMS, INC. $721,615 Grant Trans-NIH Recovery Act Research Support: 'Several projects were funded under this award. Project #1 - To evaluate and qualify new assays for infant diagnosis and viral load monitoring of HIV under standard laboratory conditions prior to field testing. Outputs: 1 or 2 manuscripts Delivera Health and Human Services, Department of / National Institutes of Health 7/20/2010
TRUSTEES OF TUFTS COLLEGE INC $219,440 Grant Trans-NIH Recovery Act Research Support: Collagen is the most abundant protein in the body, defined by its unique triple-helical conformation and repeating sequence pattern with glycine as every third residue. Biophysical studies are proposed to relate the (Gly-X-Y)n amino acid sequence and brea Health and Human Services, Department of / National Institutes of Health 9/01/2010
WHITEHEAD INSTITUTE FOR BIO-MEDICAL RESEARCH $230,250 Grant Trans-NIH Recovery Act Research Support: In this application we proposed to study the role of five miRNAs - miR-144, 451, 221, 222, and 223 - in terminal proliferation and differentiation of murine erythroid CFU-E progenitors and in the proliferation of BFU-E progenitors and the formation of CFU Health and Human Services, Department of / National Institutes of Health 9/28/2010
MIRIMEDICAL, LLC $87,000 Grant Trans-NIH Recovery Act Research Support: We propose to test (in-vitro) a small surface area double fiber bundle (DFB) dialyzer, on the order of 1.6 sq m. This device will be designed for the low blood flow (<300 ml/min) and dialysate flow (<400 ml/min) markets, which include daily dialysis, noc Health and Human Services, Department of / National Institutes of Health 7/06/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $157,528 Grant Trans-NIH Recovery Act Research Support: Adrenocortical dysplasia (acd) is a spontaneous autosomal recessive mouse mutation that exhibits a pleiotropic phenotype that includes embryonic and perinatal lethality. The embryologic defects in acd mutant embryos consist of truncation of the posterior Health and Human Services, Department of / National Institutes of Health 7/13/2010
UNIVERSITY OF ILLINOIS $195,507 Grant Trans-NIH Recovery Act Research Support: The goals of this project are to elucidate the mechanisms involved in the inhibition of Apical Sodium Dependent Bile Acid Transporter (ASBT) by cellular phosphatases, vesicular trafficking and lipid raft-dependent mechanisms. The proposed studies are als Health and Human Services, Department of / National Institutes of Health 7/15/2010
CARL ZEISS MICROIMAGING, LLC $22,540 Contract : Laboratory Equipment; microscope Health and Human Services, Department of / National Institutes of Health 9/28/2010
DUKE UNIVERSITY $345,735 Grant Trans-NIH Recovery Act Research Support: Whereas dementia and stroke affect only fraction of the population, there is a type of brain dysfunction that will affect all of us G??if we live long enough: normal aging. As we age, the anatomical and functional integrity of our brain declines, and so Health and Human Services, Department of / National Institutes of Health 9/21/2010
UNIVERSITY OF TEXAS M D ANDERSON $900,000 Grant Trans-NIH Recovery Act Research Support: The proposed Genome Data Analysis Center B (GDAC B) will work cooperatively with other GDACs funded by The Cancer Genome Atlas (TCGA) project to (i) develop an innovative, integrative pipeline for systems- level analysis of TCGA's molecular profiling data Health and Human Services, Department of / National Institutes of Health 9/23/2010
UNIVERSITY CORPORATION, THE $356,884 Grant Trans-NIH Recovery Act Research Support: Thousands of children are victimized by abuse and neglect every year. These acts result in child fatalities and detrimentally affect children's physical and mental well-being. Investigations often are initiated to prevent these negative outcomes and incre Health and Human Services, Department of / National Institutes of Health 8/10/2010
BECKMAN COULTER, INC. $894,491 Contract : Biomek XP and Biomek FX Systems with related accessories and disposable items supplied with those systems Health and Human Services, Department of / National Institutes of Health 9/24/2010
MONTANA STATE UNIVERSITY, INC $330,884 Grant Trans-NIH Recovery Act Research Support: A long term goal of the Principal Investigator's research effort in the Department of Microbiology at Montana State University, is to determine the structure of human neutrophil of flavocytochrome b and understand how changes in its structure and associat Health and Human Services, Department of / National Institutes of Health 8/02/2010
COMMONWEALTH MEDICAL COLLEGE, THE $493,815 Grant Trans-NIH Recovery Act Research Support: As breast and ovarian carcinoma progress the tumor cells develop invasive structures, which provide the cells with a mechanism to cross tissue barriers and metastasize. Activation of the tyrosine kinase cSrc is known to occur in breast and ovarian cancers Health and Human Services, Department of / National Institutes of Health 8/12/2009
UNIVERSITY OF UTAH, THE $77,704 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Development of the vertebrate musculoskeletal system requires the coordinated morphogenesis of muscle, muscle connective tissue, tendon, and skeleton. In the limb, muscle derives from migratory precursors originating f Health and Human Services, Department of / National Institutes of Health 7/06/2010
MOUNT SINAI SCHOOL OF MEDICINE $50,000 Grant Trans-NIH Recovery Act Research Support: Pancreatic islet transplantation is a potential cure for Type I diabetes, a disease which afflicts nearly 2 million persons in the United States, making it the second most common chronic disease in young people. A major challenge is the protection of the Health and Human Services, Department of / National Institutes of Health 8/02/2010
UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. $2,883,041 Grant Trans-NIH Recovery Act Research Support: This award funds the purchase of a state-of-the-art 3 Tesla, multi-channel, 70cm bore MRI scanner that will be used to support and expand the biomedical research program of the University of Kansas Medical Center (KUMC) in Kansas City KS. This system will Health and Human Services, Department of / National Institutes of Health 7/29/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $223,368 Grant Trans-NIH Recovery Act Research Support: 'The goal of this supplemental award is to establish the program in CER-STAT, or Comparative Effectiveness Research: Summer Training in Applications and Techniques. By providing rigorous training and mentoring opportunities that focus on CER, we can furni Health and Human Services, Department of / National Institutes of Health 7/08/2010
TRUSTEES OF INDIANA UNIVERSITY $47,835 Grant Trans-NIH Recovery Act Research Support: Haemophilus ducreyi causes the genital ulcer disease, chancroid. Like other GUDs, chancroid facilitates the acquisition and transmission of HIV. Understanding bacterial factors that contribute to H. ducreyi pathogenesis is a prerequisite for the developme Health and Human Services, Department of / National Institutes of Health 8/23/2010
UNIVERSITY OF WISCONSIN SYSTEM $1,844,274 Grant Trans-NIH Recovery Act Research Support: This proposal addresses Thematic Area 2: Translating Basic Science Discoveries into New and Better Treatments. In particular we are proposing the development of a new human blood-brain barrier (BBB) model derived from stem cell sources amenable to high th Health and Human Services, Department of / National Institutes of Health 9/30/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $320,490 Grant Trans-NIH Recovery Act Research Support: This project will utilize high-throughput genetic technologies in a major longitudinal behavioral study and renew the biomedical research community by building scientific partnerships for the integration of behavioral and genetic science. The 7,000 indivi Health and Human Services, Department of / National Institutes of Health 9/21/2010
PREMITEC INC $2,303,564 Grant Trans-NIH Recovery Act Research Support: Premitec, Inc., in collaboration with the Doheny Eye Institute at the University of Southern California has developed novel, 3-dimensional wide field microelectrode arrays (3D-WFA) for retinal prosthesis. These devices can double the visual field for reti Health and Human Services, Department of / National Institutes of Health 7/26/2010
MASSACHUSETTS INSTITUTE OF TECHNOLOGY $411,215 Grant Trans-NIH Recovery Act Research Support: This award will enable the development of new methods for the synthesis of enantiomerically enriched organic molecules that are anticipated to have unique activity toward biological targets of importance in cancer therapy. Health and Human Services, Department of / National Institutes of Health 9/16/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $3,084,337 Grant Trans-NIH Recovery Act Research Support: This application addresses the thematic area of Translating Basic Science Discoveries into New and Better Treatment. Recessive dystrophic epidermolysis bullosa (RDEB) is an incurable, inherited mechano- bullous disease of the skin characterized by skin fr Health and Human Services, Department of / National Institutes of Health 9/20/2010
CASE WESTERN RESERVE UNIVERSITY $503,530 Grant Trans-NIH Recovery Act Research Support: Inflammatory bowel disease (IBD) affects approximately 1.4 million individuals in the US and several million worldwide. One of the major discoveries in the last 20 years in IBD research has been the key role cytokines play in intestinal inflammation and t Health and Human Services, Department of / National Institutes of Health 8/16/2010
UNIVERSITY OF IOWA, THE $7,969,325 Grant Trans-NIH Recovery Act Research Support: The University of Iowa is requesting funds to support the purchase of a state-of-the-art Siemens seven Tesla whole body MRI system to support the research efforts of 33 funded NIH investigators from five colleges (Medicine, Engineering, Public Health, Lib Health and Human Services, Department of / National Institutes of Health 7/01/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $2,000,000 Grant Trans-NIH Recovery Act Research Support: Using a newly-developed tool, Profiles, we will assemble a range of data about individuals (demographics, research, teaching and service-related information) and about the environment and policies and practices of the institutions in which the individuals Health and Human Services, Department of / National Institutes of Health 9/30/2010
CALIFORNIA INSTITUTE OF TECHNOLOGY $188,672 Grant Trans-NIH Recovery Act Research Support: Concept demonstration for adaptive 4Pi fluorescence microscopy This application proposes to demonstrate the concept of an adaptive 4Pi microscope that is capable of high lateral and axial resolution imaging. A typical 4Pi microscope consists of two cou Health and Human Services, Department of / National Institutes of Health 8/27/2010
CLINICAL TRIALS & SURVEYS CORP. $1,264,296 Contract : RECOVERY-Normal fetal growth is a critical component to a healthy pregnancy and the long-term health of the child. An objective assessment of normal and abnormal fetal growth has enormous utility in prenatal care, neonatal care and outcome-based research. Health and Human Services, Department of / National Institutes of Health 9/27/2010
DUKE UNIVERSITY $62,244 Grant Trans-NIH Recovery Act Research Support: Diabetes is a common and costly disease with severe complications. Despite evidence that tight control of blood sugar prevents complication, only about 40% of patients with diabetes have adequate blood sugar control. Approximately 75% of all patients with Health and Human Services, Department of / National Institutes of Health 8/06/2010
GILBANE BUILDING COMPANY $131,640,100 Contract : Construction Manager as Constructor at Risk services to renovation Building 10, F Wing in two phases: Phase A of the F Wing Renovation: Pre construction, construction, activation/occupancy and closeout; to convert 64,000 gsf of former patient care units o Health and Human Services, Department of / National Institutes of Health 7/30/2010
UNIVERSITY OF ARIZONA $378,750 Grant Trans-NIH Recovery Act Research Support: Type 1 diabetes (T1 D) is a tissue specific autoimmune disease characterized by the T mediated destruction of the insulin producing b cells of the islets of Langerhans. Treatment of diabetes has focused on the use of insulin replacement. However, th is tr Health and Human Services, Department of / National Institutes of Health 8/04/2010
BALTIMORE CITY HEALTHY START INC $155,353 Grant Trans-NIH Recovery Act Research Support: This is an administrative supplement awarded with American Recovery and Reinvestment Act (ARRA) funds. This award provides additional funding for Grant # U01HD044207-08. These funds were rebudgeted and approved for a retention specialist, two interviewe Health and Human Services, Department of / National Institutes of Health 9/22/2010
PALO ALTO MEDICAL FOUNDATION FOR HEALTH CARE, RESEARCH AND EDUCATION (INC) $820,231 Grant Trans-NIH Recovery Act Research Support: The medical office visit is the foundation of medical care and one of the most important professional activities of primary care physicians who are often the only source of mental health services for older adults. Evidence continues to show that the gap b Health and Human Services, Department of / National Institutes of Health 8/05/2010
TOSK INC $199,500 Grant Trans-NIH Recovery Act Research Support: Very compelling data are available to suggest oxidative stress is an underlying component of many significant human diseases such as diabetes, heart disease, cerebrovascular disease (eg, stroke), peripheral vascular disease, neurodegeneration (Alzheimer's Health and Human Services, Department of / National Institutes of Health 7/16/2010
SIEMENS MEDICAL SOLUTIONS USA, INC. $2,740,805 Contract : The AXIOM zee Biplane is a High-resolution digital imaging system with high quality image display, DICOM network connection and syngo user interface. In order to provide highest level system availability, the imaging system consists of two independent c Health and Human Services, Department of / National Institutes of Health 9/23/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $377,982 Contract : The purpose of this procurement is to obtain contract development services that will develop and test computational approaches to on or more cognitive problems as commonly encountered by clinical researcher, biologis, or patient. Artificial neural nets, Health and Human Services, Department of / National Institutes of Health 9/21/2010
UNIVERSITY OF NEVADA, RENO $134,969 Grant Trans-NIH Recovery Act Research Support: Our research objective is to determine the signal transduction mechanisms that are unique to, or altered in the human myometrium in preterm labor because this is presently unknown and because current treatments for premature labor (PTL) are wholly inadequ Health and Human Services, Department of / National Institutes of Health 9/22/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $95,000 Grant Trans-NIH Recovery Act Research Support: Type 2 diabetes (T2D) has become a major public health problem worldwide. Among the contributing environmental factors, changes in dietary patterns and physical activity are undoubtedly key causal factors. At the same time, there is growing evidence that Health and Human Services, Department of / National Institutes of Health 9/30/2010
CHILDREN'S HOSPITAL CORPORATION, THE $491,408 Grant Trans-NIH Recovery Act Research Support: The goal of the proposed research is to apply state-of-the-art automated question answering techniques to the domain of clinical question answering. I have the expertise and resources necessary to carry out the research. My training is in computational li Health and Human Services, Department of / National Institutes of Health 8/29/2010
LOGICAL TECHNICAL SERVICES CORP. $14,520 Contract : Provide support for the Federal Financial Reporting (FFR) Project Module in the Commons to collect all new information required by FFR. The modification will allow for the requirement that grant recipients periodically submit reports ont heir grant's fin Health and Human Services, Department of / National Institutes of Health 5/12/2010
MEDICAL UNIVERSITY OF SOUTH CAROLINA $52,947 Grant Trans-NIH Recovery Act Research Support: This project investigates the role of beta-arrestin 1 and 2 as negative regulators of inflammatory response in collagen-induced arthritis. Understanding beta-arrestin 1 and 2 expression in correlation to the disease severity, its cellular specificity in t Health and Human Services, Department of / National Institutes of Health 8/02/2010
ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE $1,089,382 Grant Trans-NIH Recovery Act Research Support: The Pediatric HIV AIDS Cohort Study addresses two critical research questions: (1) the consequences of fetal and infant exposure to antiretroviral therapy (ART) when used to prevent mother-to-child transmission of HIV-1, and (2) the clinical course of per Health and Human Services, Department of / National Institutes of Health 9/01/2010
UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE $227,500 Grant Trans-NIH Recovery Act Research Support: Aim #1: Compare non-pregnant to timed-pregnant mice infected with a lethal dose of influenza virus to determine if the increased maternal mortality is mediated by an excessive viral load associated with increased pulmonary injury, profound systemic hypoxi Health and Human Services, Department of / National Institutes of Health 8/25/2010
ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE $318,804 Grant Trans-NIH Recovery Act Research Support: The current application is submitted in response to the notice number NOT-OD-058 entitled 'Enabling RPGs to Leverage NCRR Center and Centers-like Programs'. The research focus of the parent grant RO1AI0470889 is to develop a vaccine targeting human malari Health and Human Services, Department of / National Institutes of Health 9/13/2010
APPLIED BIOSYSTEMS, LLC $52,995 Contract : LABORATORY EQUIPMENT AND SUPPLIES Health and Human Services, Department of / National Institutes of Health 9/15/2010
NEW YORK UNIVERSITY (INC) $145,881 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Germ cells are essential for the maintenance of all sexually reproducing species. Many cellular and molecular aspects of germ cell behavior including their early development as primordial germ cells (PGCs) and their di Health and Human Services, Department of / National Institutes of Health 7/07/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $207,923 Grant Trans-NIH Recovery Act Research Support: Among those regulatory pathways mediated by lymphocytes, CD25+ Foxp3+ regulatory T (Treg) cells play a critical role in establishing and maintaining immunological tolerance. 2 subsets of Treg cells have been described. NaturalTreg (nTreg) cells arise as Health and Human Services, Department of / National Institutes of Health 7/12/2010
WASHINGTON UNIVERSITY, THE $250,000 Grant Trans-NIH Recovery Act Research Support: This is a supplement to the KL2 Career Development Component of the Washington University CTSA grant in response to the ?Comparative Effectiveness Research, CER, Workforce Development Announcement?: NOT-OD-10-037. The goal of this announcement was to exp Health and Human Services, Department of / National Institutes of Health 8/05/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $368,000 Grant Trans-NIH Recovery Act Research Support: The purpose of this ARRA administrative supplement is to perform microarray analyses using existing samples collected by the GPN PBR to identify circulating miRNAs as biomarkers of spontaneous preterm delivery in maternal serum, and tissue levels of miRNA Health and Human Services, Department of / National Institutes of Health 8/18/2010
MICHIGAN STATE UNIVERSITY $73,723 Grant Trans-NIH Recovery Act Research Support: Decidualization -- adaptation of the uterus to enable implantation of an embryo -- is an essential process for successful establishment of pregnancy. Impairment of the process is associated with infertility and early pregnancy loss. This supplemental gran Health and Human Services, Department of / National Institutes of Health 7/29/2010
SCRIPPS RESEARCH INSTITUTE, THE $3,284,735 Grant Trans-NIH Recovery Act Research Support: The majority of human neurological and psychiatric disorders involve impairment in learning and memory. This project will identify all genes in the genome of a model organism that have fundamental roles in the neurobiological processes underlying learning Health and Human Services, Department of / National Institutes of Health 9/30/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $499,976 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This proposal seeks to support and develop junior clinical investigators in therapeutic cancer research at the Albert Einstein College of Medicine, through a coordinated program of mentoring, didactic course work, coll Health and Human Services, Department of / National Institutes of Health 9/09/2010
THE VANDERBILT UNIVERSITY $37,830 Contract : The Vanderbilt University has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of head and neck cases. These cases are all primary and untreated. The Health and Human Services, Department of / National Institutes of Health 7/13/2010
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK $387,263 Grant Trans-NIH Recovery Act Research Support: Bacteria in the genus Yersinia cause a range of human diseases, including bubonic and pneumonic plague, infections of the intestinal lymphoid system, and lethal systemic infections. A number of virulence factors are common to pathogenic Yersinia species, Health and Human Services, Department of / National Institutes of Health 7/26/2010
CREIGHTON UNIVERSITY $78,589 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The use of anti-retroviral agents (ART), namely highly active anti-retroviral therapy (HAART) has significantly diminished the mortality associated with human immunodeficiency virus type-1 (HIV-1) disease. However, tre Health and Human Services, Department of / National Institutes of Health 9/29/2010
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA $994,445 Grant Trans-NIH Recovery Act Research Support: The California Breast Cancer Research Program (CBCRP) of the University of California and Commonweal (a nonprofit organization) propose an innovative project ? Community-based Research Infrastructure to Better Science (CRIBS) ? to stimulate community-base Health and Human Services, Department of / National Institutes of Health 9/27/2010
SEATTLE CHILDREN'S HOSPITAL $84,715 Grant Trans-NIH Recovery Act Research Support: Chronic pain is an important public health issue, affecting as many as 25% of adolescents. Over half of these adolescents report sleep disturbances, such as insomnia, that have the potential to diminish normal daily function, disturb mood, and hinder qual Health and Human Services, Department of / National Institutes of Health 9/16/2010
HAMILTON COMPANY $158,576 Contract : RECOVERY ACT: MICROLAB STARLET Automated sample handling system including parts, accessories, and applicable software, delivery, installation, training, service and support, and warranty. Health and Human Services, Department of / National Institutes of Health 8/16/2010
YALE UNIVERSITY $89,383 Grant Trans-NIH Recovery Act Research Support: Piwi/Argonaute (Ago) is the only known protein family with function in stem cell self-renewal highly conserved in both animal and plant kingdoms. These proteins also play key roles in germline development and RNAi/miRNA-mediated mechanisms. Our long term Health and Human Services, Department of / National Institutes of Health 7/30/2010
HEALTH RESEARCH, INC. $536,044 Grant Trans-NIH Recovery Act Research Support: The major object of this project is to study processes that are central to coronavirus replication. Targeted RNA recombination, other reverse genetic methodologies, and complementary biochemical and molecular biological analyses will be employed for two s Health and Human Services, Department of / National Institutes of Health 7/26/2010
UNIVERSITY OF CHICAGO, THE $1,131,386 Grant Trans-NIH Recovery Act Research Support: The purpose of this supplement is to strengthen two core facilities by adding two key pieces of equipment that will improve our capability to support translational research in the area of Cancer Immunology. The Human Immunologic Monitoring (HIM) facility Health and Human Services, Department of / National Institutes of Health 9/22/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $613,809 Grant Trans-NIH Recovery Act Research Support: UCLA AIDS PREVENTION AND TREATMENT CLINICAL TRIALS UNIT The UCLA AIDS Prevention and Treatment Clinical Trials Unit (UCLA-APT-CTU) is a multidisciplinary research unit composed of a core administrative unit and four clinical research sites in metropolitan Health and Human Services, Department of / National Institutes of Health 9/13/2010
MEDICAL UNIVERSITY OF SOUTH CAROLINA $500,000 Grant Trans-NIH Recovery Act Research Support: This proposal deals with platelet disorder. Platelet disorder, directly or indirectly, affects all human inflammatory diseases. One of the major pathways for platelet activation is through the interaction between platelet glycoprotein Ib-IX-V complex and Health and Human Services, Department of / National Institutes of Health 8/30/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $875,417 Grant Trans-NIH Recovery Act Research Support: This project will develop statistical approaches to personalized medicine in Comparative Effectiveness Research (CER). The methods can be used to guide and tailor the treatment or disease screening strategies for individual patients. These methods will en Health and Human Services, Department of / National Institutes of Health 9/30/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $104,150 Grant Trans-NIH Recovery Act Research Support: 'Toward the NIH goal of expanding the number of researchers qualified to oversee or conduct comparative effectiveness research (CER), the purposes of this supplement are to: 1) expand the existing opportunities for trainees via CER-related coursework and Health and Human Services, Department of / National Institutes of Health 8/26/2010
UNIVERSITY OF IOWA, THE $75,084 Grant Trans-NIH Recovery Act Research Support: Negative reinforcement (i.e., escape from or avoidance of instructions) has been identified as one of the leading variables responsible for the maintenance of destructive behavior exhibited by individuals with developmental disabilities. Several treatment Health and Human Services, Department of / National Institutes of Health 9/07/2010
SOUTHERN ILLINOIS UNIVERSITY $29,704 Grant Trans-NIH Recovery Act Research Support: The purpose of my funded ARRA grant is accelerating the tempo of scientific research on active NIH grants. The award of this grant will support the hiring of additional researcher in my lab. Accomplishment of the research goals are expected to signifi Health and Human Services, Department of / National Institutes of Health 7/07/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO $79,627 Grant Trans-NIH Recovery Act Research Support: Pathogenic poxviruses such as variola virus and monkeypox virus pose a dangerous threat to today's largely unimmunized population, while attenuated poxviruses hold great promise as vaccine vectors. The need for both anti-poxvirus therapies and better poxv Health and Human Services, Department of / National Institutes of Health 9/13/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $516,219 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to identify and isolate hepatic stem/progenitor cells that give rise to oval cells; to study the molecular mechanisms underlying the activation of these cells; to identify factors and signaling molecules that participate in ova Health and Human Services, Department of / National Institutes of Health 7/15/2010
OHIO STATE UNIVERSITY RESEARCH FOUNDATION $126,979 Grant Trans-NIH Recovery Act Research Support: There is no compelling physiological theory that explains all eleven basic color categories in the English language. Linguistic relativists (following the Sapir-Whorf view) argue that no such theory is likely to be found, because they believe that color c Health and Human Services, Department of / National Institutes of Health 2/01/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $900,137 Grant Trans-NIH Recovery Act Research Support: We are seeking support to establish a Genome Characterization Center, as a part of the Cancer Genome Atlas Project in Boston. The goal of the proposed effort is to analyze 2,000-2,500 tumor samples each year over a five-year period of time and identify a Health and Human Services, Department of / National Institutes of Health 9/17/2010
CHILDREN'S HOSPITAL & RESEARCH CENTER $645,010 Grant Trans-NIH Recovery Act Research Support: This is a translational research proposal to elucidate the mechanisms underlying apparent differences in end-organ iron deposition between patients with sickle cell anemia (SCD), thalassemia (TM) and Diamond Blackfan Anemia (DBA). Increasing numbers of Health and Human Services, Department of / National Institutes of Health 9/10/2009
ANC RESEARCH & DEVELOPMENT, LLC $648,929 Contract : Purchase of Leica TCS SP5 II Multi-Photon & Spectral Confocal System Health and Human Services, Department of / National Institutes of Health 8/31/2010
UNIVERSITY OF DAYTON $218,250 Grant Trans-NIH Recovery Act Research Support: This is an ACADEMIC RESEARCH ENHANCEMENT AWARD (R15) issued under ARRA 2009, from National Institute of Health (NIH) (NICHD ) to perform research on a project entitled' Genetic control of Axial Patterning in Drosophila eye'. Health and Human Services, Department of / National Institutes of Health 6/30/2010
UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON $394,229 Grant Trans-NIH Recovery Act Research Support: Inflammatory Bowel Diseases (IBDs) reflect dysregulated immune responses to gut flora where CD4+ T cells cause tissue damage. Colonic subepithelial myfibroblasts (CMFs), a cell population located directly subadjacent to the epithelium, interact with and a Health and Human Services, Department of / National Institutes of Health 8/02/2010
NORTHWESTERN UNIVERSITY $180,030 Grant Trans-NIH Recovery Act Research Support: The overall goal of this proposed research to gain a better understanding of the molecular mechanisms underlying the development of rheumatoid arthritis, a chronic debilitating disease of the joints. We have demonstrated that the type III histone deacetyl Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF CHICAGO, THE $19,453 Grant Trans-NIH Recovery Act Research Support: Comparative effectiveness research (CER) primarily involves estimation of causal effects of alternative treatments on outcomes. To this end, observational databases are a promising source of information on patient-level treatments and outcomes. However, o Health and Human Services, Department of / National Institutes of Health 9/28/2010
J CRAIG VENTER INSTITUTE INC $1,188,187 Grant Trans-NIH Recovery Act Research Support: Overall Purpose: The soil environment constitutes a very complex and competitive ecological niche occupied by numerous species of microbes. Within this niche, filamentous fungi employ a diverse array of bioactive compounds, termed natural products, to me Health and Human Services, Department of / National Institutes of Health 8/16/2010
THOMAS JEFFERSON UNIVERSITY $232,000 Grant Trans-NIH Recovery Act Research Support: Arsenic is widely spread in the environment such as soil, minerals, smoke, contaminated air and water. Epidemiologic studies showed that inorganic arsenic exposure induced lung, skin, liver, and bladder cancers. However, the etiology and molecular mechan Health and Human Services, Department of / National Institutes of Health 8/25/2010
HEALTH RESEARCH, INC. $374,990 Grant Trans-NIH Recovery Act Research Support: The purpose of this investigation is to develop project management/tracking systems to evaluate the Gynecologic Oncology Group?s protocol development and management processes to identify barriers and recommend strategies for improvement. The award was is Health and Human Services, Department of / National Institutes of Health 7/07/2010
CASE WESTERN RESERVE UNIVERSITY $102,050 Grant Trans-NIH Recovery Act Research Support: The purpose of this supplement is to develop a rapid and high throughput diagnostic test for identifying mutations in the CHD7 gene. We expect the test to facilitate a quick and thorough evaluation of the extent of which CHD7 mutations contribute to human Health and Human Services, Department of / National Institutes of Health 7/08/2010
UNIVERSITY OF WISCONSIN SYSTEM $82,657 Grant Trans-NIH Recovery Act Research Support: This NIAID-supported project uses a nonhuman primate model to investigate the adverse effects of maternal infection with influenza virus during pregnancy on infant brain development and behavior postpartum. In addition to being a potential cause of morbid Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF MASSACHUSETTS $100,000 Grant Trans-NIH Recovery Act Research Support: This award was intended to obtain an upgraded microscope that will be used in NIAID funded projects Health and Human Services, Department of / National Institutes of Health 8/23/2010
SOUTH CAROLINA RESEARCH FOUNDATION $133,258 Grant Trans-NIH Recovery Act Research Support: Alcohol Exposure, Social Behavior and Development The parent grant examines the impact of alcohol exposure during development on deficits in social behavior. The animal model of Fetal Alcohol Spectrum Disorders (FASD) exposes rats to alcohol during both Health and Human Services, Department of / National Institutes of Health 9/03/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $33,482 Grant Trans-NIH Recovery Act Research Support: The A2ALL consortium was chartered in 2002 and has collected data on a large cohort of donor and recipient candidates for LDLT spanning over a decade of activity in 9 US centers. Dr. Emond has been a Co-chair of A2ALL and a member of the Project Executive Health and Human Services, Department of / National Institutes of Health 9/30/2010
INSON MEDICAL SYSTEMS, INC. $199,917 Grant Trans-NIH Recovery Act Research Support: Ocular Drug Delivery Devices for Improved Postoperative Cataract Care Health and Human Services, Department of / National Institutes of Health 7/28/2010
UNIVERSITY OF UTAH, THE $143,908 Grant Trans-NIH Recovery Act Research Support: Spinal muscular atrophy is the most common inherited motor neuron disease in humans, with an incidence of 1 in 8,000 live births. It is a leading cause of hereditary infant and childhood mortality. Homozygous deletion of the survival motor neuron 1 (SMN1) Health and Human Services, Department of / National Institutes of Health 7/06/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $175,200 Grant Trans-NIH Recovery Act Research Support: This is a request for supplemental ARRA funding for an existing U19 grant for 1 year. We are currently requesting a no cost extension. With the requested funds will support the salary for new personnel to establish several new approaches in our U19 gran Health and Human Services, Department of / National Institutes of Health 7/19/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $997,227 Grant Trans-NIH Recovery Act Research Support: Enhancing Community/Academic Clinical Research Collaboration From its inception, the Michigan Institute for Clinical and Health Research (MICHR) Community Engagement Program (CE) has based its efforts on the guiding principles of Community Based Participa Health and Human Services, Department of / National Institutes of Health 8/19/2010
THE VANDERBILT UNIVERSITY $870,323 Grant Trans-NIH Recovery Act Research Support: This project will provide a critically needed and thoroughly evaluated statistical technique to conduct comparative effectiveness research studies using observational data. We will evaluate the application of propensity score methods to common situations Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $237,750 Grant Trans-NIH Recovery Act Research Support: While the thiazolidinedione (TZD) drugs are widely used to treat type 2 diabetes, how they work and cause their side effects is not fully understood. Here we will examine how the hormone, FGF21, contributes to the beneficial and harmful effects of TZDs. I Health and Human Services, Department of / National Institutes of Health 7/05/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $49,968 Grant Trans-NIH Recovery Act Research Support: This proposal is to obtain funding for hiring a new Research Technician for one year. We identified and hired a Research Technician who is helping out the PI to perform experiments outlined in the parental K08 grant and in the attached research proposal. Health and Human Services, Department of / National Institutes of Health 8/16/2010
UNION GRADUATE COLLEGE $54,170 Grant Trans-NIH Recovery Act Research Support: E-enhanced Collaborative Ethics Committee Review of Research Protocols:Union Graduate College proposes to use a commercially-available suite of electronic collaboration tools to develop a customizable and scalable online platform to facilitate joint revie Health and Human Services, Department of / National Institutes of Health 9/15/2010
DANA-FARBER CANCER INSTITUTE, INC. $4,585,020 Grant Trans-NIH Recovery Act Research Support: Abstract This application is in response to Recovery Act Limited Competition: NIH Director's Opportunity for Research in Five Thematic Areas (RC4). In particular we are responding to (Theme 1) Applying Genomics and Other High Throughput Technologies and ( Health and Human Services, Department of / National Institutes of Health 9/01/2010
TRINITY UNIVERSITY $199,600 Grant Trans-NIH Recovery Act Research Support: As part of learning a language, children must learn individual words in that language, including verbs. Learning a new verb is difficult because verbs refer to dynamic and transient events, and languages vary in the way their verb categories are construc Health and Human Services, Department of / National Institutes of Health 7/27/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $482,861 Grant Trans-NIH Recovery Act Research Support: Chemist/biologist collaborations facilitating tool development through collaborations between a chemist(s) and a biologist(s). Recent advances in single-cell technology have revealed cell-to-cell transcriptional differences in isogenic populations of bact Health and Human Services, Department of / National Institutes of Health 8/02/2010
OREGON HEALTH & SCIENCE UNIVERSITY $996,091 Grant Trans-NIH Recovery Act Research Support: Objectives: To create the IT, data-sharing, education, and oversight tools necessary for a patient-driven, national adult congenital heart disease research network. Aims: (1) To demonstrate the feasibility of a patient-centered research model for patients Health and Human Services, Department of / National Institutes of Health 7/20/2010
SANARIA INC. $986,281 Grant Trans-NIH Recovery Act Research Support: Universal Attenuated Malaria Sporozoite Vaccine and Challenge System Health and Human Services, Department of / National Institutes of Health 7/06/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $703,902 Grant Trans-NIH Recovery Act Research Support: Our proposal directly addresses the Program Announcement (RFA-AI-10-003) goals of ?development of broadspectrum (innate immunity) immunotherapeutic that targets NIAID Priority Agents' and establishment of ?collaborations between researchers in different d Health and Human Services, Department of / National Institutes of Health 8/02/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $401,188 Grant Trans-NIH Recovery Act Research Support: Liver transplantation, with lifelong immunosuppression, remains the treatment of choice for patients with a variety of acute and chronic liver diseases. Immunosuppression, however, is associated with deleterious side effects including chronic rejection an Health and Human Services, Department of / National Institutes of Health 7/12/2010
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY $58,117 Grant Trans-NIH Recovery Act Research Support: Fertilization is biological process with important medical, social and economic implications. From extensive study, the events of fertilization are known in some detail. However, the molecular underpinnings of these events generally remain elusive. Most p Health and Human Services, Department of / National Institutes of Health 7/19/2010
ADVANCED TARGETING SYSTEMS $3,000,000 Grant Trans-NIH Recovery Act Research Support: Pain due to cancer is one of the great fears, at times greater than even death, in the progression of the disease. Numerous studies have shown the preponderance of pain in terminal cases. But even worse, many times this pain is refractory to the last stan Health and Human Services, Department of / National Institutes of Health 9/01/2010
NORTHWESTERN UNIVERSITY $1,150,035 Contract : RECOVERY The primary objectives are to:1) describe the trajectory of fetal growth in twins using two- and three-dimensional ultrasound, 2) compare trajectories of fetal growth between singleton and twin gestations (according to chorionicity) to determine Health and Human Services, Department of / National Institutes of Health 9/23/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $237,750 Grant Trans-NIH Recovery Act Research Support: PROJECT NARRATIVE In the proposed research, we will focus on defining the genetic and epigenetic mechanisms that mediate expression of aromatase, the key enzyme in estrogen synthesis, in placenta and in breast cancer. In view of the suggested role of inad Health and Human Services, Department of / National Institutes of Health 7/05/2010
VMT, INC. $241,875 Grant Trans-NIH Recovery Act Research Support: The goal of this phase I effort is to create and assess feasibility for the critical components for a flexible, extremely low cost, voice-based natural language processing enabled data entry system for private practice primary care physicians. Workflow de Health and Human Services, Department of / National Institutes of Health 8/17/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON $164,258 Grant Trans-NIH Recovery Act Research Support: Supplement to a primary grant, this initiative involves multiple institutions & addresses 3 G?bullet pointG? topics specified in the RFA: 1) CER skills for diverse health care researchers; 2) CER methodology skills development by economists, quality impro Health and Human Services, Department of / National Institutes of Health 9/23/2010
UNIVERSITY OF HOUSTON SYSTEM $341,934 Grant Trans-NIH Recovery Act Research Support: Nitric oxide (NO) is a cell signaling molecule that is involved in numerous biological processes. The Principal Investigator (PI) will look at the possible role of NO in fertility. Studies with rats have shown that NO has an effect on both reproduction Health and Human Services, Department of / National Institutes of Health 8/26/2010
CHARLES RIVER LABORATORIES, INC. $51,670 Contract : Histology Services to include H&E Stained Slides, Decalcification of Bone Tissue, and Unstained Slides in multiple shipments Health and Human Services, Department of / National Institutes of Health 9/29/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $33,683 Grant Trans-NIH Recovery Act Research Support: This supplement request is for retaining one post-doctoral fellow and providing funds for associated supplies to accelerate research in Specfic Aim 1 of the parent grant. The long-term goal of this project is to understand the cellular and molecular mecha Health and Human Services, Department of / National Institutes of Health 3/08/2010
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION $162,803 Grant Trans-NIH Recovery Act Research Support: Center for Experimental Neurorehabilitation Training (CENT)- This grant is designed to enhance the parent project's mission to promote research in the field of neurorehabilitation by providing technology that could improve research at a very basic level. Health and Human Services, Department of / National Institutes of Health 7/21/2010
BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE $1,000,003 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): With dramatic advances in the understanding of the genetic basis of cancer over the past decade, genetic cancer risk assessment (GCRA) has emerged as a distinct clinical consultative service. GCRA utilizes rapidly evol Health and Human Services, Department of / National Institutes of Health 8/09/2010
UNIVERSITY OF FLORIDA $351,740 Grant Trans-NIH Recovery Act Research Support: Prospective Studies of Avian Influenza Transmission in Asia The H5N1 avian influenza epidemic that has ravaged multiple species in Asia, now threatens the United States. National response plans call for aggressive human case identification, antiviral use, Health and Human Services, Department of / National Institutes of Health 8/09/2010
UNIVERSITY OF TEXAS AT AUSTIN $156,198 Grant Trans-NIH Recovery Act Research Support: This project will archive and disseminate the Adolescent Health and Academic Achievement data set, which promises to be widely used. These are unique data, linking together information on students grades, specific courses taken, attitudes towards schooli Health and Human Services, Department of / National Institutes of Health 9/27/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $756,579 Contract : ITKv4 Project Title: Fundamental Refactoring of Deformable Image Registration in ITK with Distributed Computing and GPU Acceleration Health and Human Services, Department of / National Institutes of Health 6/21/2010
THOMAS JEFFERSON UNIVERSITY $118,959 Grant Trans-NIH Recovery Act Research Support: This supplement will be used exclusively to pusue the generation and characterization of new lines of mice expressing a mutant form of the inhibitory Fc receptor FcgammaRIIB from a transgene. Maintenance of this research will allow the continued employme Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF MIAMI $228,000 Grant Trans-NIH Recovery Act Research Support: The ultimate goal of this new project is recruit new sequencing technology to detect, identify and catalogue all microorganisms that populate human ocular surface, and can potentially affect vision. This is the first comprehensive characterization of micr Health and Human Services, Department of / National Institutes of Health 8/31/2010
CASE WESTERN RESERVE UNIVERSITY $942,573 Grant Trans-NIH Recovery Act Research Support: It is estimated that 5.3 million Americans have Alzheimer's disease (AD), and that the number and proportion of Americans affected by AD is expected to grow rapidly in the next several decades. The striking increase in numbers of individuals with AD has b Health and Human Services, Department of / National Institutes of Health 9/28/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $455,280 Grant Trans-NIH Recovery Act Research Support: Shared High Throughput X-ray Diffraction Equipment The X-ray diffraction equipment will enable the research by at least 14 different research groups to advance our understanding of the structures of biological molecules and the roles they play in health Health and Human Services, Department of / National Institutes of Health 7/08/2010
UNIVERSITY OF ILLINOIS $1,517,021 Grant Trans-NIH Recovery Act Research Support: The development of new therapeutic drugs against the coronavirus causing Severe Acute Respiratory Syndrome (SARS) is a continuing imperative. Following its emergence in Guangdong Province, China, in November 2002, SARS-coronavirus (SARS-CoV) spread to ot Health and Human Services, Department of / National Institutes of Health 7/26/2010
UNIVERSITY OF PITTSBURGH THE $886,790 Contract : In vitro screening of combinations to treat cancer. The Work Assignment (WA) for N01-CM-52202 (Julie Eiseman, PI) has three separate phases: the Pilot Phase (3 months), the Production Phase (12 months) and Data Analysis Phase (3 months). We will use a Health and Human Services, Department of / National Institutes of Health 9/19/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $3,723,748 Grant Trans-NIH Recovery Act Research Support: Applying Genomics and Other High Throughput Technologies is the thematic area that this application addresses. Ovarian cancer is the most lethal gynecologic malignancy. It has a high response rate to initial combined platinum taxane chemotherapy following Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF TEXAS AT AUSTIN $173,410 Grant Trans-NIH Recovery Act Research Support: NTDs are a group of common, structural malformation that is associated with excess morbidity and mortality. A specific etiologic agent(s) cannot be identified in the majority of individuals with NTDs, and in this group of patients the condition is believe Health and Human Services, Department of / National Institutes of Health 9/13/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $427,464 Grant Trans-NIH Recovery Act Research Support: The funded project that seeks supplemental funding sets out in its three aims to examine the effects of the envelope protein of CCR5 (R5) tropic HIV-1, gp120, on T cell function and localization during acute infection. We propose that this viral protein Health and Human Services, Department of / National Institutes of Health 9/27/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $62,167 Grant Trans-NIH Recovery Act Research Support: Type 1 diabetes mellitus (T1DM) is currently managed using modulation of dietary carbohydrates and insulin. Paradoxical post-meal hyperglucagonemia is associated with post-prandial hyperglycemia in T1DM. Glucagon suppressors such as the amylin analog, pra Health and Human Services, Department of / National Institutes of Health 9/24/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $228,000 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Degenerative diseases of the retina are responsible for devastating visual handicap affecting millions of individuals worldwide. Monogenic disorders with relatively early age-of-onset have been mapped to over 200 genet Health and Human Services, Department of / National Institutes of Health 8/31/2010
MILLIPORE CORPORATION $58,897 Contract : Laboratory Supplies Health and Human Services, Department of / National Institutes of Health 9/28/2010
THE JACKSON LABORATORY $236,235 Grant Trans-NIH Recovery Act Research Support: For the past five years, the ReproGenomics Program at The Jackson Laboratory has produced novel mutant models of infertility as a resource for the community of reproductive biologists. The mutations produced and mapped by this program in this relatively s Health and Human Services, Department of / National Institutes of Health 8/26/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $141,449 Grant Trans-NIH Recovery Act Research Support: Integrin adhesion receptors play a vital role in cell function and development by mediating the adhesion of cells to other cells and to extracellular matrix proteins. In the immune system, the functional activity of integrins expressed on T lymphocytes is Health and Human Services, Department of / National Institutes of Health 7/06/2010
BAYLOR COLLEGE OF MEDICINE $137,310 Grant Trans-NIH Recovery Act Research Support: Purpose: To test the hypothesis that coactivator posttranslational modifications control the in vivo systems biology of mammals. Health and Human Services, Department of / National Institutes of Health 9/30/2010
OKLAHOMA MEDICAL RESEARCH FOUNDATION $1,321,636 Grant Trans-NIH Recovery Act Research Support: This project is designed to consolidate the nucleic acid sequencing services at the Oklahoma Medical Research Foundation into one unified core facility. This project consists of four major phases. In phase one of the project we will enhance the computatio Health and Human Services, Department of / National Institutes of Health 7/22/2010
BECKMAN COULTER, INC. $18,808 Contract : DU800 HP Kinetics (390392) Health and Human Services, Department of / National Institutes of Health 9/28/2010
UNIVERSITY OF NORTHERN COLORADO $402,668 Grant Trans-NIH Recovery Act Research Support: Experimental Tacaribe Virus Infection of Jamaican Fruit Bats: Bats have recently been implicated as reservoirs or potential reservoirs of several human pathogens, including ebolaviruses, marburgviruses, SARS coronavirus, and Nipah and Hendra paramyxoviru Health and Human Services, Department of / National Institutes of Health 7/19/2010
TEXAS AGRILIFE RESEARCH $130,845 Grant Trans-NIH Recovery Act Research Support: In the United States, it is estimated that about 1% of all babies will be born using assisted reproductive technologies and these numbers continue to grow at a steady rate. The promise of assisting infertile couples to have a family has been realized, but Health and Human Services, Department of / National Institutes of Health 7/01/2010
DREXEL UNIVERSITY $76,959 Grant Trans-NIH Recovery Act Research Support: Amyotrophic lateral sclerosis (ALS) is characterized by the progressive and selective loss of motor neurons (MNs) in the motor cortex, brainstem, and spinal cord, resulting in death of patients 2-5 years after diagnosis. Glutamate-mediated excitotoxicity Health and Human Services, Department of / National Institutes of Health 9/06/2010
UNIVERSITY OF WASHINGTON $411,292 Grant Trans-NIH Recovery Act Research Support: We propose to create an innovative post-graduate training experience focused on multidisciplinary problem solving in Global Health. The occurrence and transmission of infectious disease in populations is often an 'end product' of shortcomings in social, e Health and Human Services, Department of / National Institutes of Health 9/26/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $183,811 Grant Trans-NIH Recovery Act Research Support: Persistence of cancer cells even after surgery and androgen-ablation therapy, their proliferation, androgen independence and invasion to distant sites is the major cause of deaths in human prostate cancer patients. Delaying or slowing down the process of Health and Human Services, Department of / National Institutes of Health 7/20/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $152,945 Grant Trans-NIH Recovery Act Research Support: A critical component of the Weill Cornell CTSC (WC/CTSC) is the training of a diverse group of future investigators through our Clinical and Translational Education Program (CTEP). Included in the program , and as part of our initial K30 grant, we develo Health and Human Services, Department of / National Institutes of Health 9/23/2010
GEORGETOWN UNIVERSITY (THE) $191,877 Grant Trans-NIH Recovery Act Research Support: The Community Child Health Network (CCHN) Phase II research proposes to: (1) advance understanding of the combined biomedical, social, behavioral, and environmental influences on the course of prenatal development, pregnancy outcome, and early child devel Health and Human Services, Department of / National Institutes of Health 9/22/2010
CANCER PREVENTION INSTITUTE OF CALIFORNIA $999,998 Grant Trans-NIH Recovery Act Research Support: Vietnamese Americans have socio-economic and health disparities and are medically underserved. The objective of this project is to provide infrastructure services to the community and academic health centers (AHC) to overcome collaboration barriers to for Health and Human Services, Department of / National Institutes of Health 7/06/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $372,500 Grant Trans-NIH Recovery Act Research Support: The glaucomas are a group of vision impairing diseases characterized by progressive optic nerve damage, retinal ganglion cell death, and visual field loss. Risk factors include age, family history, anterior segment dysgenesis, elevated intraocular pressu Health and Human Services, Department of / National Institutes of Health 7/26/2010
UNIVERSITY OF WISCONSIN SYSTEM $158,389 Grant Trans-NIH Recovery Act Research Support: NKT cells are a population of regulatory T cells that is known to be able to potently modulate immune responses. The antigens that control NKT cell activation are lipids and glycolipids presented by CD1d molecules. A remarkable characteristic of NKT cells Health and Human Services, Department of / National Institutes of Health 7/06/2010
UNIVERSITY OF MIAMI $325,264 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to assess the mucosal immunity of individuals exposed to HIV who remain uninfected. Two subprojects will investigate the innate and adaptive immunity using the same cohort of HIV exposed persons and their partners, highly expo Health and Human Services, Department of / National Institutes of Health 9/07/2010
UNIVERSITY OF WISCONSIN SYSTEM $3,161,034 Grant Trans-NIH Recovery Act Research Support: The significance and nature of this collaboration fits very well with the thematic areas applying genomics and other high throughput technologies, translating basic science discoveries into new and better treatment, using science to enable health care ref Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON $58,493 Grant Trans-NIH Recovery Act Research Support: This award is a supplement to grant R01A1075091-03 is to support the doctoral training of Arely Gonzalez in the laboratory of the P1, Michael Lorenz, in the Program for Microbiology and Molecular Genetics at the University of Texas Graduate School for Bio Health and Human Services, Department of / National Institutes of Health 9/20/2010
TRUSTEES OF INDIANA UNIVERSITY $54,200 Grant Trans-NIH Recovery Act Research Support: The overall aim of the proposed research is to create and operate a new Ethics Review Committee between Indiana University and Moi University School of Medicine in Eldoret, Kenya This new international IRB will be responsible for reviewing and approving p Health and Human Services, Department of / National Institutes of Health 9/24/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $1,400,000 Grant Trans-NIH Recovery Act Research Support: This revision proposes to establish a Center of Excellence in Comparative Effectiveness Research for Eliminating Disparities (CERED) to: 1) conduct research on the comparative effectiveness of health care delivery strategies within health disparities (HD) Health and Human Services, Department of / National Institutes of Health 9/18/2010
UNIVERSITY OF CHICAGO, THE $54,000 Grant Trans-NIH Recovery Act Research Support: The epithelial lining of the intestine forms a protective barrier which separates the luminal contents from the rest of the intestine. The integrity of the intestinal barrier is dependant upon the maintenance of the epithelial cell interactions with apica Health and Human Services, Department of / National Institutes of Health 8/01/2010
BAYLOR COLLEGE OF MEDICINE $141,442 Grant Trans-NIH Recovery Act Research Support: We are requesting Recovery Act (ARRA) Administrative Supplement for the parent grant R37 AI36040 under the notice number NOT-OD-09-056. This parent MERIT grant is in its seventh year with 3 more years. The requested supplement is for (1) purchasing an HPL Health and Human Services, Department of / National Institutes of Health 8/30/2010
UNIVERSITY OF WASHINGTON $995,133 Grant Trans-NIH Recovery Act Research Support: American Indian and Alaska Native (AI/AN) communities shoulder heavy burdens in health disparities. While health promotion programs have been implemented in AI/AN communities, evidence-based behavioral science translational research is rare. Time, monetar Health and Human Services, Department of / National Institutes of Health 7/23/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $127,127 Grant Trans-NIH Recovery Act Research Support: Fcy receptor (FcR)-mediated phagocytosis in macrophages internalizes IgG-coated particles by complex movements of membranes and the actin cytoskeleton. Phagocytosis requires the G proteins Cdc42 and Rac, and phosphoinositide 3'- kinase (PI3K), which gener Health and Human Services, Department of / National Institutes of Health 7/12/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $80,436 Grant Trans-NIH Recovery Act Research Support: I requested supplemental funding for my grant entitled Foveal and parafoveal codes in reading (HD26765). The goal of the funding request was to enable us to pursue potentially interesting work dealing with reading in deaf readers and older readers. The Health and Human Services, Department of / National Institutes of Health 7/29/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $188,774 Grant Trans-NIH Recovery Act Research Support: The proposed project is an extension of the ongoing parent project, and will investigate the effect of reduced cigarette nicotine content in menthol cigarette smokers. The project will provide important data on behavior and use patterns and toxin biomark Health and Human Services, Department of / National Institutes of Health 8/19/2010
SIEMENS INDUSTRY, INC. $909,622 Contract : Rocky Mountain Labs (RML) Campuswide building automation system (BAS) upgrades. The contractor will provide the necessary personnel and materials required to complete all work required to complete the BAS upgrade for various buildings. Health and Human Services, Department of / National Institutes of Health 9/20/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $335,592 Grant Trans-NIH Recovery Act Research Support: The goal of this administrative supplement is to facilitate the original goals of the parent grant, RC2HG005556 'Defining the genetic basis of human respiratory chain disease.' In the parent grant we are applying next-generation sequencing technology to s Health and Human Services, Department of / National Institutes of Health 7/30/2010
COPPER RIVER INFORMATION TECHNOLOGY, LLC $856,992 Contract : The contractor will provide the necessary equipment, supplies, materials, and labor to integrate the legacy Clinical Center Radiology Information System (RIS) with the the current V11 Carestream Health, Inc. Picture Archiving and Communications System (PA Health and Human Services, Department of / National Institutes of Health 7/15/2010
CASE WESTERN RESERVE UNIVERSITY $257,592 Grant Trans-NIH Recovery Act Research Support: The project continues a productive and successful program of strongly collaborative studies on the biomedical consequences of lipid oxidation. It focuses on the role of lipid-derived oxidative protein and ethanolamine phospholipid modification in eye dise Health and Human Services, Department of / National Institutes of Health 7/30/2010
RESEARCH TRIANGLE INSTITUTE $550,000 Grant Trans-NIH Recovery Act Research Support: A consortium of obstetric researchers recently has been brought together, with NICHD support, to investigate the genomic and proteomic basis for adverse pregnancy outcomes in nulliparous women (Preterm Birth in Nulliparous Women: An Understudied Populatio Health and Human Services, Department of / National Institutes of Health 7/13/2010
SRI INTERNATIONAL $377,997 Contract : Evidence Based Expert System to assist in treatment of Depression. The purpose of the project is to develop and test computational approaches to one or more cognitive problems as commonly encountered by clinicians, clinical researchers, biologists or pat Health and Human Services, Department of / National Institutes of Health 9/27/2010
DUKE UNIVERSITY $392,500 Grant Trans-NIH Recovery Act Research Support: Herpes Simplex Virus 1 (HSV-1) and HSV-2 are related human ?-herpesviruses that share the ability to establish long-term latent infections in neurons of primary sensory ganglia. Like other herpesviruses, HSV-1 and HSV-2 express virally encoded microRNAs ( Health and Human Services, Department of / National Institutes of Health 7/26/2010
BRITISH COLUMBIA CANCER AGENCY BRANCH $25,000 Contract : British Columbia Cancer Agency has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of peripheral blood lymphocyte specimens and endometrial specimens. Health and Human Services, Department of / National Institutes of Health 9/20/2010
BOSTON MEDICAL CENTER CORPORATION $954,402 Grant Trans-NIH Recovery Act Research Support: Award to purchase simulation equipment in support of primary care training at Boston University School of Medicine, including a simulation mannequin, a simulation auscultation torso, and associated support equipment. Health and Human Services, Department of / National Institutes of Health 9/02/2010
EPIVAX, INC. $243,561 Grant Trans-NIH Recovery Act Research Support: The major goal of this new research program (1R21AI078800-01) is to develop an improved platform for targeted HIV vaccine delivery to DCs using a novel non-tolerogenic áDEC-205 antibody (áDEC-205). The promise of this new technology is that it m Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $201,680 Grant Trans-NIH Recovery Act Research Support: The development of new technologies for the detection of copy number variation (CNV) in the human genome has had a major impact on the field of human genetics. In our ongoing efforts to characterize patterns of structrual variation in human populations, Health and Human Services, Department of / National Institutes of Health 7/14/2010
UNIVERSITY OF WASHINGTON $210,829 Grant Trans-NIH Recovery Act Research Support: This application for an administrative supplement to 'Development of Speech Perception and Brain Plasticity' is relevant to the parent grant and well within its peer-reviewed and approved scope. The supplement will serve to advance the general and specifi Health and Human Services, Department of / National Institutes of Health 8/01/2010
UNIVERSITY OF WASHINGTON $4,784,830 Grant Trans-NIH Recovery Act Research Support: The objective of the project is to accelerate collaboration and a new model for multidisciplinary interaction across cognitive neuroscience, human neuroimaging and medicine at the University of Washington. The project specifically uses the infrastructure Health and Human Services, Department of / National Institutes of Health 9/28/2010
NORTHWESTERN UNIVERSITY $223,770 Grant Trans-NIH Recovery Act Research Support: Nuclear receptors bind to hormones and vitamins and regulate the activity of hormone inducible genes which in turn influence a cascade of events that impact almost all physiologic pathways including cell differentiation, fat metabolism, energy homeostasis Health and Human Services, Department of / National Institutes of Health 7/05/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $140,500 Grant Trans-NIH Recovery Act Research Support: To investigate the effect of IUGR with postnatal calorie modifications on male and female skeletal muscle a) transcriptional machinery involved in GLUT4 expression and b) function assessed by quantifying glucose utilization-in-vivo under basal and hyperin Health and Human Services, Department of / National Institutes of Health 7/27/2010
GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. $71,094 Contract : Medical College of Georgia has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of thyroid and oral cavity squamous cell carcinoma (OSCC) tissue (40 tot Health and Human Services, Department of / National Institutes of Health 8/26/2010
TUFTS MEDICAL CENTER PARENT, INC. $308,991 Grant Trans-NIH Recovery Act Research Support: The proposal of the administrative supplement is to perform additional measurements in serum (N=940) and urine (N=3484) in participants as an ancillary study to the Age, Gene/Environment Susceptibility-Reykjavic Study (AGES-Reykjavik Study) (N01-AG-1-210 Health and Human Services, Department of / National Institutes of Health 9/30/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $560,194 Grant Trans-NIH Recovery Act Research Support: This proposal is in response to the American Recovery and Reinvestment Act of 2009 (Notice Number NOT-OD-09-056) for an Administrative Supplement to NHGRI grant U01 HG004271. We are requesting funds to augment one specific aim in the parent grant. In Spec Health and Human Services, Department of / National Institutes of Health 8/06/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $6,206,455 Grant Trans-NIH Recovery Act Research Support: The broad goals of the project are to identify determinants of susceptibility and resistance to infection by HIV-1 subtype C and of disease progression among people severely affected by the HIV/AIDS epidemic in southern Africa, and to reduce the burden of Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF OKLAHOMA $55,003 Grant Trans-NIH Recovery Act Research Support: Autosomal Polycystic Kidney Disease (ADPKD) is caused by mutations in PKD1 and PKD2 gene that encode polycystinl (PC1) and polycystin2 (PC2). PC2 is a non-selective Ca2+-permeable channel, which may function in more than one subcellular location (plasma m Health and Human Services, Department of / National Institutes of Health 7/22/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $999,701 Grant Trans-NIH Recovery Act Research Support: Induced pluripotent stem (iPS) cells are a novel source for derivation of donor populations in cell replacement therapy. However, because the major applications of iPS cells relate to diseases predominately affecting elderly populations such as heart fail Health and Human Services, Department of / National Institutes of Health 9/24/2010
CASE WESTERN RESERVE UNIVERSITY $805,318 Grant Trans-NIH Recovery Act Research Support: Metaplastic transformation of the esophagus, termed Barrett's esophagus (BE) is a premalignant condition with a 1 per 200 patient-years risk of malignant progression to esophageal adenocarcinoma. The incidence of esophageal adenocarcinoma has increased dr Health and Human Services, Department of / National Institutes of Health 9/30/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $50,000 Grant Trans-NIH Recovery Act Research Support: The opportunity to impact clinical kidney disease: Chronic kidney disease affects more than 20 million Americans and is a major risk factor for cardiovascular mortality. End Stage Kidney Disease, costs in the order of $20 billion per year in the US, and d Health and Human Services, Department of / National Institutes of Health 9/29/2010
FRED HUTCHINSON CANCER RESEARCH CENTER $1,091,952 Grant Trans-NIH Recovery Act Research Support: Many studies comparing methods to prevent, treat, or cure cancer do not have the time or the information to evaluate how the approaches being studied affect cancer deaths. This study will develop a software system to translate the results of these studies Health and Human Services, Department of / National Institutes of Health 9/20/2010
MOUNT SINAI SCHOOL OF MEDICINE $1,400,000 Grant Trans-NIH Recovery Act Research Support: This revision will add two additional aims to the Center's mission. CERED-1: Develop, conduct, and promote CER to improve health, healthcare quality, and equity in the Harlem community; and CERED-2: Accelerate the translation of CERED into practice by com Health and Human Services, Department of / National Institutes of Health 7/31/2010
UNIVERSITY HEALTH NETWORK $93,290 Contract : The University Health Network has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of head and neck cases. These cases are all primary and untreated. Health and Human Services, Department of / National Institutes of Health 8/27/2010
MAYO CLINIC $161,254 Grant Trans-NIH Recovery Act Research Support: Drug-induced liver injury (Dill) remains a major public health problem of national and worldwide importance. In turn, the National Institutes of Health created the Drug Induced Liver Injury Network (DILlN) in 2003 to stimulate and facilitate research on t Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF WISCONSIN SYSTEM $107,413 Grant Trans-NIH Recovery Act Research Support: The pregnant uterus is an immunologically privileged site. Despite major histocompatibility complex (MHC) and minor H differences, rejection of the fetus by mother is rare and acceptance of migrant maternal cells by the offspring is common. We recently sh Health and Human Services, Department of / National Institutes of Health 7/12/2010
UNIVERSITY OF WASHINGTON $483,614 Grant Trans-NIH Recovery Act Research Support: The specific aims for this project is: 1. Develop, implement and evaluate a state-of-the-art Comparative Effectiveness Research (CER) lecture series (ie. grand rounds) 2. Develop curriculum and hands-on training activities for a weeklong summer Symposposi Health and Human Services, Department of / National Institutes of Health 9/23/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $469,212 Grant Trans-NIH Recovery Act Research Support: This is an application for an ABI-Sciex 5500 Qtrap to support research by 10 named NIH investigators who are carrying out research on biological pathways, protein complexes, protein post-translational modifications and small biologically active peptides i Health and Human Services, Department of / National Institutes of Health 7/15/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $153,000 Grant Trans-NIH Recovery Act Research Support: The primary goal of this application is to identify genes and other genomic features that underlie the action of alcohol. While we have made considerable progress toward this objective through the use mouse quantitative trait loci (QTL) mapping, gene exp Health and Human Services, Department of / National Institutes of Health 8/09/2010
EMORY UNIVERSITY $155,873 Grant Trans-NIH Recovery Act Research Support: RETINOID EFFECTS ON INFLAMMATION AND CELL GROWTH ASSOCIATED WITH ENDOMETRIOSIS. Retinoids are essential to the differentiation and development of reproductive tissue, including that from the endometrium and ovaries. In portions of the parent grant relatin Health and Human Services, Department of / National Institutes of Health 7/29/2010
VISIONQUEST BIOMEDICAL LLC $199,944 Grant Trans-NIH Recovery Act Research Support: The goal of this grant is to develop optimal methods for estimating atherosclerotic plaque deformation. The innovation in the proposed approach comes from the development of several new methods developed by the principal collaborators. This includes the Health and Human Services, Department of / National Institutes of Health 8/09/2010
UNIVERSITY OF MARYLAND $1,298,153 Grant Trans-NIH Recovery Act Research Support: In the current year more than 1.5 million new cancer cases will be diagnosed (American Cancer Society, 2008) and nearly 11 million Americans have a history of cancer. The annual costs for medical care for patients with cancer was an estimated $219 billion Health and Human Services, Department of / National Institutes of Health 8/16/2010
JOHNS HOPKINS UNIVERSITY, THE $115,965 Grant Trans-NIH Recovery Act Research Support: The expanding availability of genome wide information on single nucleotide polymorphism (SNP) variants that increase risk for common diseases has sparked public debate about whether such information is useful for patients and health care providers. Unlike Health and Human Services, Department of / National Institutes of Health 9/20/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON $999,999 Grant Trans-NIH Recovery Act Research Support: Hispanic farmworkers and their families suffer a disproportionate number of injuries and illnesses associated with their work and limited personal resources. Over the next two years, we intend to establish a sustainable national farmworker research networ Health and Human Services, Department of / National Institutes of Health 7/07/2010
INTERACTIVE DRAMA, INC $1,499,987 Contract : Internet software for the Conversim/Virtual Conversations System for the Remote Virtual Dialogue Software Research Project Health and Human Services, Department of / National Institutes of Health 9/17/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $50,000 Grant Trans-NIH Recovery Act Research Support: In accordance with the objectives of the American Recovery and Reinvestment Act of 2009 (ARRA) Administrative Supplements, this supplement application will: 1) promote new job creation, and 2) accelerate both the tempo and the achievement of research. Sup Health and Human Services, Department of / National Institutes of Health 8/30/2010
PALO ALTO INSTITUTE FOR RESEARCH AND EDUCATION, INC. $78,960 Grant Trans-NIH Recovery Act Research Support: This grant provides a diversity supplement for an African-American postdoctoral fellow engaging in an exciting series of studies of the role of a novel immune cell trafficking receptor (CMKLR1) in experimental autoimmune encephalomyelitis (EAE), a mouse m Health and Human Services, Department of / National Institutes of Health 8/09/2010
CASE WESTERN RESERVE UNIVERSITY $71,396 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The innate immune system recognizes and responds to pathogenic organisms. In doing so, this system is responsible for initiating a cytokine response designed to tailor the adaptive immune system to eradicate the offend Health and Human Services, Department of / National Institutes of Health 8/10/2009
TRUSTEES OF INDIANA UNIVERSITY $217,662 Grant Trans-NIH Recovery Act Research Support: We are proposing a clinical study evaluating the mechanism underlying the therapeutic response using serum samples obtained from the patients participating in G?TONIC clinical trialG? funded by the NIDDK. We hypothesize that the biochemical and histologic Health and Human Services, Department of / National Institutes of Health 7/27/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $378,705 Grant Trans-NIH Recovery Act Research Support: The goal of this proposal is to trace the emergence of low-level object processing operations as they evolve in time and cortical area. We are studying the mechanisms by which the visual system segments the visual scene into objects using a combination of Health and Human Services, Department of / National Institutes of Health 8/09/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $1,494,822 Grant Trans-NIH Recovery Act Research Support: This proposal addresses the difficulty of using observational data to drawing causal inferences on treatment effects. Methodological advances in this area have enormous implications for efforts to identify the most promising leverage points for interventi Health and Human Services, Department of / National Institutes of Health 9/30/2010
AR CHILDRENS HOSPITAL RESEARCH INSTITUTE $404,250 Grant Trans-NIH Recovery Act Research Support: Chlamydial infection elicits a strong acute inflammatory response which not only is responsible for the pathologic response but is also necessary to control the infection until the adaptive immune response is activated. Ultimately, a Th1 response is requi Health and Human Services, Department of / National Institutes of Health 6/04/2009
SPELMAN COLLEGE $29,408 Grant Trans-NIH Recovery Act Research Support: This award creates a part-time position that will provide income for either a current graduate student or someone who has appropriate experience and wishes to be in the workforce or supplement other income on a part-time basis. In addition, by accelerati Health and Human Services, Department of / National Institutes of Health 9/01/2010
CHILDRENS HOSPITAL OF PHILADELPHIA $150,415 Grant Trans-NIH Recovery Act Research Support: This proposal requests funds for the acquisition of a Meso Scale Discovery SECTOR 6000 Imager for the detection of biomarkers by direct sandwich immunoassay in single and multiplex formats. The Meso Scale Discovery biomarker detection technology is based Health and Human Services, Department of / National Institutes of Health 7/15/2010
ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE $186,306 Grant Trans-NIH Recovery Act Research Support: A decade ago when microarray was first invented, it was hailed as 'an array of hope' in Nature Genetics and has received a considerable amount of attention in biomedicine. Subsequently it has been called 'an array of problems' in Nature Review. An inheren Health and Human Services, Department of / National Institutes of Health 8/09/2010
MILTENYI BIOTEC INC $14,871 Contract : autoMACS columns, CD4+T Cell Isolation Kit II Mouse, B Cell Isolatin Kit Mouse, CD8+T Cell Isolation Kit II Mouse. Health and Human Services, Department of / National Institutes of Health 8/11/2010
UNIVERSITY OF KENTUCKY $1,000,000 Grant Trans-NIH Recovery Act Research Support: Kentuckians living in rural Appalachia suffer a disproportionate burden of negative health disparities, which is especially evident for persons with neurological conditions (spinal cord injury (SCI) traumatic brain injury (TBI) and stroke). Recently, the Health and Human Services, Department of / National Institutes of Health 7/06/2010
PROGENICS PHARMACEUTICALS, INC. $4,143,652 Grant Trans-NIH Recovery Act Research Support: Award Title:-? Novel, Non-antibiotic Therapy for Clostridium difficile-Associated Disease Award Description: Clostridium difficile is a spore-forming bacterium that is the leading cause of hospital acquired diarrhea and is responsible for more deaths per Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF TEXAS AT AUSTIN $76,750 Grant Trans-NIH Recovery Act Research Support: Recent research points to the complexity of immigrant generations. Immigrants arriving as children rather than as adults, interethnic marriage, and marriage between co-ethnics of different generations create a wide variety of marital unions, and the part Health and Human Services, Department of / National Institutes of Health 8/18/2010
KAISER FOUNDATION HOSPITALS $767,193 Grant Trans-NIH Recovery Act Research Support: The overall objective of this application is to improve the understanding of early events leading to BarrettG??s esophagus (a risk factor for esophageal adenocarcinoma) and to identify potential targets for early intervention. BarrettG??s esophagus is a Health and Human Services, Department of / National Institutes of Health 8/16/2010
UNIVERSITY OF ARIZONA $378,750 Grant Trans-NIH Recovery Act Research Support: The establishment and maintenance of epithelial tight junction integrity is essential to the normal function of epithelial organs; above all, the ability of the intestinal epithelium to serve as a selective barrier to antigens and pathogens while absorbin Health and Human Services, Department of / National Institutes of Health 7/31/2010
ACIONT INC $2,171,045 Grant Trans-NIH Recovery Act Research Support: The overarching aim of this innovative proposal is to develop and then commercialize a non-invasive topical product which is safe and easy to administer that treats severe uveitis, including intermediate and posterior uveitis. Uveitis is the third leading Health and Human Services, Department of / National Institutes of Health 9/30/2009
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $63,000 Grant Trans-NIH Recovery Act Research Support: A better understanding of genetic factors that influence the severity of cerebral palsy (CP) in children or their role in repair and recovery could lead to new, innovative treatments that mitigate disability and improve functional outcomes. Apolipoprotein Health and Human Services, Department of / National Institutes of Health 9/02/2010
CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND $440,000 Grant Trans-NIH Recovery Act Research Support: The +?-hemoglobinopathies sickle cell disease and +?-thalassemia are among the most common, and most devastating, genetic diseases worldwide. In countries with developed health care systems, care for affected individuals is extremely expensive; in develop Health and Human Services, Department of / National Institutes of Health 5/29/2009
MATTHEWS MEDIA GROUP, INC. $3,400,000 Contract : EXPAND AND PROMOTE RESOURCES FOR NCI SMOKING CESSATION RESOURCES Health and Human Services, Department of / National Institutes of Health 4/30/2010
WASHINGTON UNIVERSITY, THE $250,000 Grant Trans-NIH Recovery Act Research Support: The purpose of this ARRA funded Comparative Effectiveness Research (CER) Workforce Development Administrative Supplement is to expand the number of researchers qualified to oversee and conduct CER, to promote job creation and economic development and to a Health and Human Services, Department of / National Institutes of Health 7/22/2010
UNIVERSITY OF TENNESSEE $154,653 Grant Trans-NIH Recovery Act Research Support: The overall goal of the parent grant for this supplement is to develop safe and effective vaccines to prevent group A streptococcal infections and their sequelae. We are requesting an administrative supplement in response to RFA NOT-OD-09-056 which, if f Health and Human Services, Department of / National Institutes of Health 8/23/2010
UNIVERSITY OF ARIZONA $70,438 Grant Trans-NIH Recovery Act Research Support: Neisseria gonorrhoeae (Ng) is a human pathogen that persists on human mucosal surfaces for long periods of time without causing signs of disease. Clinical and basic findings suggest development of symptomatic infection could be due to a change in the bal Health and Human Services, Department of / National Institutes of Health 8/09/2010
RANGER GROUP LLC, THE $3,796,640 Contract : 'Recovery Act' -- Repair & Upgrade Switchgear -- Misc Life Safety Repairs Health and Human Services, Department of / National Institutes of Health 3/09/2010
RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL $1,500,000 Grant Trans-NIH Recovery Act Research Support: The long-term objective of this proposal is to determine the precise role that genetics play in the development of vesicoureteral reflux, recurrent urinary tract infections (UTls), and reflux nephropathy. Aim 1: To perform array-based Comparative Genomic Health and Human Services, Department of / National Institutes of Health 9/29/2010
NET ESOLUTIONS CORPORATION $404,680 Contract : To provide requirements, analysis, and tool evaluation support for the Healthier Financial Initiative for the NIH nVision Data Warehousing Project. Health and Human Services, Department of / National Institutes of Health 6/11/2010
G BAILEY COMPANY, INC $2,888,663 Contract : RECOVERY - Design Build Services for Emergency Generator Set, Building 31. Health and Human Services, Department of / National Institutes of Health 8/19/2010
MOUNT SINAI SCHOOL OF MEDICINE $350,001 Grant Trans-NIH Recovery Act Research Support: This application concerns the analysis of molecular mechanisms of Wnt signaling in embryonic cells of Xenopus laevis. Wnt signaling pathways play a major role in the control of cell proliferation, cell polarity and cell fate determination in multiple deve Health and Human Services, Department of / National Institutes of Health 8/25/2010
LOMA LINDA UNIVERSITY $70,675 Grant Trans-NIH Recovery Act Research Support: The cellular and biochemical changes that define ripening of the prepartum cervix occur well before birth. Recent findings indicate that the ripening process is associated with inflammation; immigration and activation of leukocytes coincide with the disco Health and Human Services, Department of / National Institutes of Health 9/23/2009
HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC. $4,234,000 Grant Trans-NIH Recovery Act Research Support: We propose to purchase an 11.7T animal research Magnetic resonance imaging (MRI) and spectroscopy (MRS) scanner for the F.M. Kirby Research Center at Kennedy Krieger Institute (KKI). This scanner will be equipped with the latest coil technology (mouse cry Health and Human Services, Department of / National Institutes of Health 4/08/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $628,125 Grant Trans-NIH Recovery Act Research Support: 'In all 5 patients included in the combined kidney and bone marrow transplantation (CKBMT) study, analysis of PBMC (peripheral blood mononuclear cells) revealed transient multi-lineage mixed chimerism (presence of both donor- and recipient-derived cells). Health and Human Services, Department of / National Institutes of Health 7/21/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $47,000 Grant Trans-NIH Recovery Act Research Support: This supplement is to purchase new instrumentation for the Ligand Core Lab. This Core provides assay services to NIH-supported investigators both within UVA, as well as all Reproductive Sciences Branch-supported Reproductive Centers across the country. Th Health and Human Services, Department of / National Institutes of Health 8/26/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $5,683,130 Grant Trans-NIH Recovery Act Research Support: This project will utilize high-throughput genetic technologies in a major longitudinal behavioral study and renew the biomedical research community by building scientific partnerships for the integration of behavioral and genetic science. The 7,000 indivi Health and Human Services, Department of / National Institutes of Health 9/21/2010
CHILDREN'S HOSPITAL CORPORATION, THE $997,683 Grant Trans-NIH Recovery Act Research Support: We propose to establish the Children's Hospital Boston Collaborative Center for Community Health Research (the 'Center'), which will build participatory community-academic research partnerships to improve child health research and community research capac Health and Human Services, Department of / National Institutes of Health 9/20/2010
BRANDEIS UNIVERSITY $28,000 Grant Trans-NIH Recovery Act Research Support: Our long-term goal is to gain a highly mechanistic understanding of how the actin cytoskeleton directs cell polarity and cell morphogenesis. All living cells have internal and external structures tailored to and critical for their distinctive physiologica Health and Human Services, Department of / National Institutes of Health 8/31/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO $353,176 Grant Trans-NIH Recovery Act Research Support: TRIM5alpha proteins bind retroviral capsids after cell entry and restrict retroviral infection by blocking reverse transcription and/or integration of the viral genetic material {Nisole, 2005 #305; Towers, 2007 #310}. This novel mechanism of cellular immu Health and Human Services, Department of / National Institutes of Health 7/09/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $49,582 Grant Trans-NIH Recovery Act Research Support: Neurotropic viruses are important causes of morbidity and mortality throughout the world. The lack of therapeutic options for these diseases is driven by the paucity of understanding of the mechanisms by which neurotropic viruses cause disease. We propose Health and Human Services, Department of / National Institutes of Health 8/02/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO $161,955 Grant Trans-NIH Recovery Act Research Support: Food and water borne infectious diseases are a significant source of morbidity and mortality world-wide. Children are especially at risk from these infections. Although often assumed to be only a problem in developing areas of the world, bacterial infecti Health and Human Services, Department of / National Institutes of Health 9/13/2010
THE VANDERBILT UNIVERSITY $50,000 Grant Trans-NIH Recovery Act Research Support: To facilitate the efficient and effective conduct of the parent K23 Mentored Clinical Scientist Development Award that seeks to define the clinical and molecular epidemiology of community-associated methicilin-resistant Staphylococcus aureus (CA-MRSA) in Health and Human Services, Department of / National Institutes of Health 9/07/2010
SOUTHERN ILLINOIS UNIVERSITY $419,551 Grant Trans-NIH Recovery Act Research Support: This is a 3-year grant designed to look at developmental dyslexia and ADHD. These are two of the most prevalent disorders of childhood, and they have a high rate of co-occurrence. Of interest to this project is one potential source of this co-occurrence, Health and Human Services, Department of / National Institutes of Health 7/14/2010
UNIVERSITY OF CALIFORNIA, DAVIS $617,539 Grant Trans-NIH Recovery Act Research Support: Award start date is 09/30/2010. The researchers will hypothesize that age-related change in the expression of SOD2 is the resultof epigenetic changes in cytosine methylation within the gene body in the retinal pigment epithelium (RPE)/choroid. Prelimina Health and Human Services, Department of / National Institutes of Health 9/07/2010
UNIVERSITY OF MIAMI $102,403 Contract : The University of Miami has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of breast lobular and ductal cases for 65 cases. The collection of the spe Health and Human Services, Department of / National Institutes of Health 9/27/2010
HENRY FORD HEALTH SYSTEM $334,074 Contract : The Henry Ford Hospital has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of astrocytoma/glioblastoma cases. These cases are all primary and untreat Health and Human Services, Department of / National Institutes of Health 7/20/2010
UNIVERSITY OF MASSACHUSETTS $39,096 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to examine the mechanisms of sperm capacitation and the role of polycystic kidney disease proteins in capacitation. These studies require detailed examination of sperm motility and can best be carried out using a Computer Assi Health and Human Services, Department of / National Institutes of Health 7/29/2010
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. $159,624 Grant Trans-NIH Recovery Act Research Support: The health of pregnant women and their unborn children is jeopardized by malarial infection in many regions of the world. When pregnant women contract malaria, maternal anemia, preterm labor, and low birth weight babies, or, in severe cases found in low e Health and Human Services, Department of / National Institutes of Health 7/10/2010
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. $175,230 Grant Trans-NIH Recovery Act Research Support: The goals of the proposed work are to obtain data that will allow descriptions at the molecular level of how the terminal heme synthetic pathway enzymes function in higher animals, with particular emphasis on identifying previously undefined protein-prote Health and Human Services, Department of / National Institutes of Health 9/30/2010
ONEIDA COMMUNICATIONS, INC. $828,126 Contract : Professional services to provide Infrastructure Installation and procurement services Bld 10 W wing Horizontal Cabling Phase A Health and Human Services, Department of / National Institutes of Health 9/20/2010
ZACHARON PHARMACEUTICALS, INC. $175,000 Grant Trans-NIH Recovery Act Research Support: The purpose of the supplement is to accelarate our anticancer compounds toward clinical testing. These novel compounds are the first pharmacologically relevant inhibtiors of gangliosides; a class of lipid-linked glycans known to be key melanoma and neur Health and Human Services, Department of / National Institutes of Health 9/09/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $127,702 Grant Trans-NIH Recovery Act Research Support: Title: The Role of PIAS1 in immune regulation. This adminstrative supplement request is to support Dr. Shuai?s parent NIH grant (#5R01AI063286), the overall goal of which is to investigate the role of PIAS1 (protein inhibitor of activated STAT1) in the re Health and Human Services, Department of / National Institutes of Health 8/02/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $396,147 Grant Trans-NIH Recovery Act Research Support: Project Summary To address the shortcomings of current methods of monitoring stents for occlusion, the goal of the proposed work is to develop and verify the performance of a system that wirelessly monitors the buildup of occlusive material in a stent. Th Health and Human Services, Department of / National Institutes of Health 7/07/2010
HEKTOEN INSTITUTE FOR MEDICAL RESEARCH, THE $269,696 Grant Trans-NIH Recovery Act Research Support: Determine the changes in bacterial microbiota in HIV infected non-progressors, HIV infected progressors and HIV-seronegative women from the Chicago WIHS site over an eight to ten year period between 2000- 2010. We hypothesize that the types, diversity and Health and Human Services, Department of / National Institutes of Health 9/29/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $88,800 Grant Trans-NIH Recovery Act Research Support: Many basic and clinical studies, particularly in the HIV arena, rely on flow cytometry for collecting and analysizing the study data needed. Recent advances in flow cytometry instrumentation and reagent availability have opened the way to processing large Health and Human Services, Department of / National Institutes of Health 8/16/2010
UNIVERSITY OF MASSACHUSETTS $73,220 Grant Trans-NIH Recovery Act Research Support: Mammalian sperm are not able to fertilize eggs immediately after ejaculation. They acquire fertilization capacity after residing in the female tract for a finite period of time in a process known as capacitation [24, 25]. Initially, capacitation was defin Health and Human Services, Department of / National Institutes of Health 7/19/2010
UNIVERSITY OF CONNECTICUT $145,610 Grant Trans-NIH Recovery Act Research Support: This award funds an intensive period of mentored training in geospatial conceptualization and analysis with a focus on an application to HIV prevention trials; the mentor is Dr. Ellen K. Cromley, internationally known for her scholarship relating geospati Health and Human Services, Department of / National Institutes of Health 9/20/2010
NEW YORK UNIVERSITY (INC) $134,793 Grant Trans-NIH Recovery Act Research Support: Due to a successful biomedical research effort great strides have been made in understanding pathologic processes and developing new therapies for once untreatable diseases. Nonetheless, there are speed bumps on the road to more efficient and productive r Health and Human Services, Department of / National Institutes of Health 7/29/2010
UNIVERSITY OF NEBRASKA $80,000 Grant Trans-NIH Recovery Act Research Support: Heavy alcohol intake is known to damage the ability of the lung to protect itself from infections such as pneumonia and bronchitis. The lung's first line of defense against such infection is to trap inhaled particles and propel them out of the lung using Health and Human Services, Department of / National Institutes of Health 9/03/2010
THE UNIVERSITY OF AKRON $214,877 Grant Trans-NIH Recovery Act Research Support: This supplement will accelerate the progress of the four aims of the parent grant by adding a postdoctoral research associate, who is a leading expert in the synthesis and study of silver carbene complexes (SCCs), to the investigative team. Further a Nuc Health and Human Services, Department of / National Institutes of Health 4/16/2010
LOUISIANA STATE UNIVERSITY SYSTEM $234,419 Grant Trans-NIH Recovery Act Research Support: The work proposed here will supplement Aim 2 of the parent grant with two more focused approaches: (1) We plan to use improved technology for the microarray screens; and (2) we plan to add depth to our functional studies of IsL-1 by investigating its role Health and Human Services, Department of / National Institutes of Health 8/01/2010
OHIO STATE UNIVERSITY, THE $343,009 Grant Trans-NIH Recovery Act Research Support: This 5-year project is a study of interactive signaling between the enteric nervous system (ENS), spinal sensory afferent nerves and enteric mast cells, with the guinea pig small intestine as the experimental model. The project tests a hypothesis, support Health and Human Services, Department of / National Institutes of Health 8/01/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $170,375 Grant Trans-NIH Recovery Act Research Support: The gastrointestinal tract is initially colonized by microbes at birth, the mucosal innate immune system requires attenuation to avoid chronic inflammation by activation of Toll-Like Receptors (TLR) pathways. A family TLR's stimulates the innate immune sy Health and Human Services, Department of / National Institutes of Health 7/27/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $393,400 Grant Trans-NIH Recovery Act Research Support: Funding was provided for salary and supplies to continue work to define the function of the Elys gene in intestinal progenitor cells.This project seeks to define cellular and molecular mechanisms that prevent theoccurrence of oncogenic mutations caused by Health and Human Services, Department of / National Institutes of Health 8/13/2010
UNIVERSITY OF CHICAGO, THE $91,026 Grant Trans-NIH Recovery Act Research Support: Successful cell division requires positioning of the division plane so that the segregated sets of chromosomes are cleanly partitioned into two separate cells. Furthermore, in some cell types, including stem cells, the division plane must be coordinated w Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $148,000 Grant Trans-NIH Recovery Act Research Support: Developmental Control of the Cell Cycle The scientific objective of this project is to elucidate how developmental programs regulate cell cycle progression, a process that remains poorly understood. The parent grant contains three specific aims containin Health and Human Services, Department of / National Institutes of Health 7/02/2010
STARKS ASSOCIATES, INC. $290,000 Contract : This contract action is to augment current trans NIH chemical libraries and NIH Roadmap with compounds and libraries that are only available from external sources in order to maximize the use of the resources of the newly formed NCI Chemical Biology Conso Health and Human Services, Department of / National Institutes of Health 9/21/2010
WASHINGTON UNIVERSITY, THE $158,258 Grant Trans-NIH Recovery Act Research Support: Pediatric lung transplantation treats end-stage lung disease of diverse etiologies in recipients with potential for normal extrapulmonary organ function and development. However, unlike other solid organ recipients, frequencies of adverse outcomes in pedi Health and Human Services, Department of / National Institutes of Health 9/29/2010
FUNDACIO PRIVADA CLINIC PER A LA RECERCA BIOMEDICA $15,000 Contract : Barcelona has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of Peripheral blood nucleated cells pre and post treatment of patients with Diffuse large Health and Human Services, Department of / National Institutes of Health 8/09/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $1,180,788 Grant Trans-NIH Recovery Act Research Support: Identify all Meckel-like ciliopathy genes by exon capture & large-scale sequencing. Identification of mutations in proteins of the primary cilia-centrosome complex (CCC) defined the disease group of 'retinal-renal ciliopathies', the most frequent genetic Health and Human Services, Department of / National Institutes of Health 9/29/2010
APERIO TECHNOLOGIES, INC. $245,707 Contract : ARRA Intramural Research Equipment: This requirement provides consolidated equipment for the NIAID (National Institute of Allergy and Infectious Diseases) Intramural Research Program for influenza studies. The deliverables include: 1 (one) ScanScope XT di Health and Human Services, Department of / National Institutes of Health 9/28/2010
NEW YORK UNIVERSITY $747,809 Grant Trans-NIH Recovery Act Research Support: Nonmarital fertility in the United States comprises a substantial portion of all U.S. fertility, with close to 40% of all births in 2006 now occurring outside of formal marriage and with increases in nonmarital fertility generating concern for the well-be Health and Human Services, Department of / National Institutes of Health 8/18/2010
UNIVERSITY OF MARYLAND BALTIMORE COUNTY $221,841 Grant Trans-NIH Recovery Act Research Support: This project explores the health and caregiving needs of childless older women who have emigrated from Russia. The aim is to better understand how older Russian immigrants with and without children think about their lives, determine what might happen in Health and Human Services, Department of / National Institutes of Health 9/30/2010
THE HOSPITAL FOR SPECIAL SURGERY FUND INC $385,550 Grant Trans-NIH Recovery Act Research Support: Under the parent grant we discovered that the glucocorticoid receptor (GR)-interacting protein (GRIP)1, an estabished nuclear receptor coregulator, which can potentiate either GR-mediated activation or repression, serves as a coactivator for the interfero Health and Human Services, Department of / National Institutes of Health 7/06/2010
PURDUE UNIVERSITY $1,309,177 Grant Trans-NIH Recovery Act Research Support: This project will bring to fruition a unique screening technology capable of identifying and tracking the appearance of pathogens or altered or modified organisms that might be used for bioterrorism. The processes to be established include remote detecti Health and Human Services, Department of / National Institutes of Health 8/09/2010
DUKE UNIVERSITY $59,661 Grant Trans-NIH Recovery Act Research Support: Mathematical abilities in adult humans exceed the numerical capacities of any non-human animal. Although neither rat nor monkey is likely to balance a checkbook or prove Pythagorous' theorem there is considerable evidence that non-human animals are capabl Health and Human Services, Department of / National Institutes of Health 7/30/2010
CHILDRENS HOSPITAL OF PHILADELPHIA $47,298 Grant Trans-NIH Recovery Act Research Support: For the past 22 years, our Mitochondria! Inborn Errors of Metabolism research project has been testing the hypothesis that: Genetic variants in the mitochondrial genome play an important role in the etiology of human disease. This research has resulted in Health and Human Services, Department of / National Institutes of Health 9/16/2010
CARL ZEISS MICROIMAGING, INC. $51,422 Contract : Laboratory Equipment Health and Human Services, Department of / National Institutes of Health 6/02/2010
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH $785,924 Grant Trans-NIH Recovery Act Research Support: Within the pilot phase of TCGA, comprehensive genomic profiling has been performed for a large set of ovarian cancer samples. The Computational Biology Center at MSKCC, led by Chris Sander, has been instrumental in providing an integrative view of the hom Health and Human Services, Department of / National Institutes of Health 9/17/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $886,973 Grant Trans-NIH Recovery Act Research Support: This revised application (A2) responds to the CTSA initiative to establish and sustain an academic-community partnership for clinical and translational research/To achieve this goal, we created the Institute for Clinical and Translational Research (ICTR Health and Human Services, Department of / National Institutes of Health 7/23/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $231,750 Grant Trans-NIH Recovery Act Research Support: Functional brain imaging using scalp-recorded electroencephalography (EEG) can be low cost, non-invasive, and highly mobile, with fine time resolution. The principal obstacle to its more widespread medical use has been the lack of adequate software to ext Health and Human Services, Department of / National Institutes of Health 9/29/2010
TRI-MECH SOLUTIONS, LLC $17,970 Contract : 3D Proto Typing Machine Health and Human Services, Department of / National Institutes of Health 9/23/2010
EDUCATION DEVELOPMENT CENTER, INC. $299,074 Grant Trans-NIH Recovery Act Research Support: This project is developing materials to augment a multi-year parent education intervention that aims to reduce HIV-related risks among African American and other black youth living in high poverty neighborhoods. Consistent with the goals of the parent gr Health and Human Services, Department of / National Institutes of Health 7/21/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $213,188 Grant Trans-NIH Recovery Act Research Support: As human retinas are rich in autofluorescent compounds, such as lipofuscin, it is not practical to use immunofluorescence methods to localize molecules in tissue sections during basic eye research or in clinical evaluations of eye pathology; this is espec Health and Human Services, Department of / National Institutes of Health 8/04/2010
UNIVERSITY OF TEXAS M D ANDERSON $181,006 Grant Trans-NIH Recovery Act Research Support: Great effort has been made in developing tumor-targeted gene delivery, but no attention has been given to targeting the therapeutic gene products that are transcribed and translated from genes transfected in normal tissues into tumors. Targeting gene prod Health and Human Services, Department of / National Institutes of Health 7/02/2010
UNIVERSITY OF IOWA, THE $220,234 Grant Trans-NIH Recovery Act Research Support: A. Purpose and Functions The Institute for Clinical and Translational Research will train highly motivated clinical research scholars for innovative careers in patient-focused research. The training programs will provide a comprehensive curriculum across Health and Human Services, Department of / National Institutes of Health 8/05/2010
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. $371,250 Grant Trans-NIH Recovery Act Research Support: Uterine receptivity is an ovarian hormone controlled transient state in which the uterus can accept an embryo to implant. Transformations in luminal endometrial epithelium (LE) mi- croenvironment are associated with the establishment of uterine receptivit Health and Human Services, Department of / National Institutes of Health 9/02/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $229,220 Grant Trans-NIH Recovery Act Research Support: The hypothesis to be examined in this project is that biliary atresia is associated with an increased frequency of certain HLA genotypes and novel shared HLA epitopes, suggesting a role for autoimmunity in the pathogenesis of this disease. This is an anci Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF ILLINOIS $992,266 Grant Trans-NIH Recovery Act Research Support: The proposed project seeks to build the infrastructure for the Community-Academic Partnership: for People Aging with DD (CAP: PADD). Specifically, the CAP: PADD project will reconfigure the bi-directional relationships between an Academic Health Center (A Health and Human Services, Department of / National Institutes of Health 8/11/2010
VATRIX MEDICAL, INC. $194,293 Grant Trans-NIH Recovery Act Research Support: Abdominal aortic aneurysms (AAAs) are associated with impaired arterial wall integrity, leading to abnormal ballooning and eventual fatal rupture. Currently the sole treatment for such aneurysms is surgical intervention. Surgical procedures entail either Health and Human Services, Department of / National Institutes of Health 5/03/2010
YALE UNIVERSITY $50,000 Grant Trans-NIH Recovery Act Research Support: Memory B cells that differentiate into antigen presenting and antibody-producing cells are important for long-term immunity to natural antigens and vaccines and may play a key role mediating the clinical manifestations of autoimmune diseases. Memory B cel Health and Human Services, Department of / National Institutes of Health 8/09/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $12,488,763 Grant Trans-NIH Recovery Act Research Support: This project proposes to test a novel strategy financial incentives to improve uptake of comparative effectiveness findings among physicians and patients to reduce cardiovascular risk. This project will focus on improving cholesterol control among Health and Human Services, Department of / National Institutes of Health 9/16/2010
SEATTLE CHILDREN'S HOSPITAL $270,169 Grant Trans-NIH Recovery Act Research Support: Cortisol Quantification Investigation (CQI), represents protocol 012 of the first cycle of the Collaborative Pediatric Critical Care Research Network (CPCCRN). This study was designed to compare centrifugal ultrafiltra-tion and equlibrium dialysis for fr Health and Human Services, Department of / National Institutes of Health 9/14/2010
SAN DIEGO STATE UNIVERSITY FOUNDATION $43,536 Grant Trans-NIH Recovery Act Research Support: The Fetal Alcohol Effects and Choline Intervention project examines the potential of choline, an essential nutrient, to reduce the severity of neuropathology and behavioral alterations associated with developmental alcohol exposure. Using an animal model Health and Human Services, Department of / National Institutes of Health 9/03/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $248,220 Grant Trans-NIH Recovery Act Research Support: In the last decade collaborative networks of providers and experts have arisen to address health issues from Africa to Asia, the Caribbean to South America. This is highlighted by the global response to the earthquake in Haiti, where web-based groups prov Health and Human Services, Department of / National Institutes of Health 9/26/2010
WATERS CORPORATION $82,747 Contract : Awarding Agency purchased laboratory equipment and supplies from Prime Recipient. Health and Human Services, Department of / National Institutes of Health 4/26/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $142,664 Grant Trans-NIH Recovery Act Research Support: B and T lymphocytes, the primary cells of the adaptive immune system, provide a major line of defense against a myriad of foreign molecules by virtue of antigen-specific receptors. The vast diversity amongst the antigen receptors genes is generated throug Health and Human Services, Department of / National Institutes of Health 9/27/2010
BROAD INSTITUTE, INC., THE $657,600 Grant Trans-NIH Recovery Act Research Support: Epigenetic modifications have been recognized as important factors in modification of gene expression levels, specification of cellular state and developmental potential, and etiology of cancer. In particular, post- translational modifications to histone Health and Human Services, Department of / National Institutes of Health 7/16/2009
UNIVERSITY OF ILLINOIS $237,243 Grant Trans-NIH Recovery Act Research Support: The overal goal of my research program is to develop a non-invasive ultrasound method to detect microstructural tissue changes in the cervix leading to labor and birth. Specifically we want to use this as a biomarker for preterm birth. In this project we Health and Human Services, Department of / National Institutes of Health 9/09/2010
WHITEHEAD INSTITUTE FOR BIO-MEDICAL RESEARCH $979,405 Grant Trans-NIH Recovery Act Research Support: To derive induced pluripotent stem cells from donated peripheral blood. We have made substantial progress with this project goal, We have been able to generate iPS cells from human fresh and frozen peripheral blood (Staerck et al 2010). Because blood i Health and Human Services, Department of / National Institutes of Health 8/27/2010
UNIVERSITY OF RHODE ISLAND $35,894 Grant Trans-NIH Recovery Act Research Support: To meet the dual threats of emerging infectious diseases and engineered biowarfare/bioterror agents, there is a pressing need for more efficient systems for vaccine development. TRIAD, or the Translational Immunology Research and Accelerated [Vaccine] Dev Health and Human Services, Department of / National Institutes of Health 7/20/2010
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH $120,705 Contract : The Sloan-Kettering Insitute for Cancer Research has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of sarcoma cases(60 cases) Health and Human Services, Department of / National Institutes of Health 9/03/2010
CHILDREN'S HOSPITAL CORPORATION, THE $333,745 Grant Trans-NIH Recovery Act Research Support: Angiogenesis, the generation of new blood vessels from pre-existing ones, is a component of many pathologic processes and is characteristically associated with cell-mediated immune inflammation. However, surprisingly little has been reported on the mechan Health and Human Services, Department of / National Institutes of Health 8/30/2010
THE VANDERBILT UNIVERSITY $1,249,351 Grant Trans-NIH Recovery Act Research Support: Herein we request an Administrative Supplement to the Cancer Center Support Grant (CCSG), which will greatly enhance and accelerate translational, bench-to-bedside research for the members of the Vanderbilt Ingram Cancer Center (VICC). The funds will supp Health and Human Services, Department of / National Institutes of Health 9/15/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $134,000 Grant Trans-NIH Recovery Act Research Support: The Harvard University Center for AIDS Research (HU CFAR) represents each of the Harvard affiliated schools and hospitals, including Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Children's Hospital Boston, the Immune Disease Institu Health and Human Services, Department of / National Institutes of Health 8/16/2010
UNIVERSITY OF TEXAS AT DALLAS $73,631 Grant Trans-NIH Recovery Act Research Support: Although Event Related Potentials (ERPs) to visual stimuli have provided vital information concerning the underlying neuronal deficits related to many medical disorders, the nature of technology currently limits the populations of study to those who can s Health and Human Services, Department of / National Institutes of Health 9/01/2010
ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE $50,000 Grant Trans-NIH Recovery Act Research Support: This is a translational research proposal to investigate the pathogenesis of Hepatitis C Virus (HCV)-related mixed cryoglobulinemia (MC). The K08 award will assist me in realizing my goal of becoming an independent physician-scientist researching viral im Health and Human Services, Department of / National Institutes of Health 8/09/2010
CEDARS-SINAI MEDICAL CENTER $162,940 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Premature ovarian failure affects up to 1% of women by the age of 40. Although the etiology of premature ovarian failure remains largely unknown, a genetic basis has been determined for selective cases. Mutations in th Health and Human Services, Department of / National Institutes of Health 7/29/2010
UNIVERSITY OF MARYLAND $1,499,866 Grant Trans-NIH Recovery Act Research Support: We propose an innovative approach to designing and conducting randomized clinical trials (RCTs) for comparative effectiveness research (CER). Evidence from 'pragmatic' RCTs can inform real-world decisions by comparing clinically relevant alternatives acro Health and Human Services, Department of / National Institutes of Health 9/23/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $140,542 Grant Trans-NIH Recovery Act Research Support: Haemophilus ducreyi is the etiologic agent of chancroid, a sexually transmitted genital ulcer disease. Very little is known about how this unencapsulated, Gram-negative bacterium evades host defenses and causes dermal lesion development. However, it has b Health and Human Services, Department of / National Institutes of Health 9/07/2010
UNIVERSITY OF LOUISVILLE $9,831 Grant Trans-NIH Recovery Act Research Support: Cardiovascular disease is the major cause of death in the U.S. Chronic arsenic ingestion causes atherosclerosis and is associated with increased mortality from myocardial infarction and stroke. Early life arsenic exposure may play a significant role in de Health and Human Services, Department of / National Institutes of Health 5/01/2010
NORTHEASTERN UNIVERSITY $377,968 Contract : Novel Machine Learning Approaches for Automatic Labeling of Medical Text by Using Knowledge for Multiple Annotators RECOVERY: Computational Thinking to Support Clinicians & Biomed Scientists Novel Machine Learning Approaches for Auto Health and Human Services, Department of / National Institutes of Health 9/22/2010
UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) $367,600 Grant Trans-NIH Recovery Act Research Support: Syphilis is a chronic, multisystemic disease caused by the spirochete, Treponema pallidum subspecies pallidum (T. pallidum). The spirochete is acquired by sexual contact and is prevalent worldwide. Congenital syphilis and neurosyphillis manifestation of t Health and Human Services, Department of / National Institutes of Health 9/15/2010
KAISER FOUNDATION HOSPITALS $1,497,560 Grant Trans-NIH Recovery Act Research Support: The overall aims of our proposal are to: Aim 1. To establish a collaborative Cardiovascular Research Network (CVRN) among 14 member plans of the HMO Research Network to create a unique national resource that leverages the network's electronic data systems Health and Human Services, Department of / National Institutes of Health 8/16/2010
UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL $173,613 Grant Trans-NIH Recovery Act Research Support: How the synthesis of SG RNA is regulated in Sindbis virus-infected cells, and how an optimal balance is maintained between the synthesis of genomic and SG RNAs are questions that are still poorly understood. Furthermore, they are pertinent to most positiv Health and Human Services, Department of / National Institutes of Health 6/15/2010
TUFTS MEDICAL CENTER PARENT, INC. $154,151 Grant Trans-NIH Recovery Act Research Support: The specific aim of this supplement is to generate glycosylated and non-glycosylated conserved and polymorphic domains of gp40 from the major Cryptosporidium subtypes in order to investigate subtype-specific immune responses to these domains. Health and Human Services, Department of / National Institutes of Health 7/26/2010
UNIVERSITY OF ROCHESTER $1,986,573 Grant Trans-NIH Recovery Act Research Support: Our goal is to conduct a randomized trial investigating the role of two different types of trainee and faculty mentoring in the promotion of resilience among underrepresented minorities including differently abled/disabled persons in biomedical research c Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF UTAH, THE $845,375 Grant Trans-NIH Recovery Act Research Support: The genetic understanding of cancer has led to enhanced individual risk assessment, improved screening guidelines, and improved outcomes based on cancer prevention, early detection, and, in some cases, targeted therapy. Huntsman Cancer Institute (HCI) is Health and Human Services, Department of / National Institutes of Health 9/15/2010
IMMUNE DISEASE INSTITUTE, INC. $3,418,113 Grant Trans-NIH Recovery Act Research Support: The immune response integrates interactions between diverse cell types, signaling molecules and pathways that can most effectively be studied in vivo. Because immune genes are amongst the most highly evolving genes and the cytokine and chemokine responses Health and Human Services, Department of / National Institutes of Health 9/27/2010
RFCUNY - CITY COLLEGE $196,484 Grant Trans-NIH Recovery Act Research Support: ARRA - TRANS-NIH RECOVERY ACT RESEARCH SUPPORT Title: Structure and Dynamic Determinants of Ion Channel Assembly by Adapter Proteins (Administrative Supplement) Abstract: The cystic fibrosis transmembrane conductance regulator (CFTR) is an essentia Health and Human Services, Department of / National Institutes of Health 7/19/2010
FLORIDA STATE UNIVERSITY, THE $941,894 Grant Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (03) Biomarker Discovery/Validation and specific Topic 03-MH-101: Biomarkers in Mental Disorders. The proposed research takes a construct-oriented approach to the identification of biomarkers for prevalent f Health and Human Services, Department of / National Institutes of Health 9/21/2009
MASSACHUSETTS GENERAL HOSPITAL, THE $114,719 Grant Trans-NIH Recovery Act Research Support: The present request is for an administrative supplement (RFA: NOT-OO-09-056) to accelerate the pace of the research plan of the parent grant 5ROI 1-10045821-04: Water and solute transport in the epididymis. The requested funds will be used to hire a post- Health and Human Services, Department of / National Institutes of Health 7/19/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $307,094 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The central goal of this project is to produce a harmonized dataset of U.S. family and fertility surveys spanning the 1955-2002 period, including the 1955 and 1960 Growth of American Families (GAP); the 1965 and 1970 N Health and Human Services, Department of / National Institutes of Health 7/29/2010
UNIVERSITY OF RHODE ISLAND $511,121 Grant Trans-NIH Recovery Act Research Support: To meet the dual threats of emerging infectious diseases and engineered biowarfare/bioterror agents, there is a pressing need for more efficient systems for vaccine development. TRIAD, or the Translational Immunology Research and Accelerated [Vaccine] Dev Health and Human Services, Department of / National Institutes of Health 7/20/2010
WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE $128,000 Grant Trans-NIH Recovery Act Research Support: This grant allowed Dr. John W. Cave to continue the studies in the Parent Grant while we reapplied to the NIH, specifically The National Institute on Deafness and other Communication Disorders. These funds have permitted the continuation of studies showin Health and Human Services, Department of / National Institutes of Health 9/01/2010
BAYLOR COLLEGE OF MEDICINE $261,638 Grant Trans-NIH Recovery Act Research Support: Statement of Purpose (15 words): To enable large RAM genomic sequence analysis and meet the challenge of next-generation DNA sequencing. Abstract: High-throughput, short read DNA sequencing technologies have transformed sequence data production, necess Health and Human Services, Department of / National Institutes of Health 7/22/2010
UNIVERSITY OF NEVADA, RENO $333,129 Grant Trans-NIH Recovery Act Research Support: The goal of the project is to increase colorectal cancer screening within the priority population of female and male adults age 50 to 85 in Northern Nevada. A successful community-based cancer patient navigator program will be modified in partnership with Health and Human Services, Department of / National Institutes of Health 9/02/2010
RHODE ISLAND HOSPITAL $171,957 Grant Trans-NIH Recovery Act Research Support: The FAVORIT trial has several design features that enhance its ability to address the question of whether lowering total homocysteine (tHcy) concentrations can reduce the risk of CVD among patients with chronic kidney disease (CKD). At the current three m Health and Human Services, Department of / National Institutes of Health 8/15/2010
CEDARS-SINAI MEDICAL CENTER $44,999 Grant Trans-NIH Recovery Act Research Support: PROJECT SUMMARY: The overriding aim of this proposal is to investigate the therapeutic potential of blocking transforming growth factor-beta (TGF-beta) signaling for Alzheimer's disease. Terrence Town, Ph.D. is currently an NRSA/NIA post-doctoral fellow w Health and Human Services, Department of / National Institutes of Health 9/21/2010